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39852813 | A Nanoparticle Comprising the Receptor-Binding Domains of Norovirus and <i>Plasmodium</i> as a Combination Vaccine Candidate. | <h4>Background</h4>Noroviruses, which cause epidemic acute gastroenteritis, and <i>Plasmodium</i> parasites, which lead to malaria, are two infectious pathogens that pose threats to public health. The protruding (P) domain of norovirus VP1 and the αTSR domain of the circumsporozoite protein (CSP) of <i>Plasmodium</i> s... |
39852564 | Role of Nanotechnology in Ischemic Stroke: Advancements in Targeted Therapies and Diagnostics for Enhanced Clinical Outcomes. | Each year, the number of cases of strokes and deaths due to this is increasing around the world. This could be due to work stress, lifestyles, unhealthy food habits, and several other reasons. Currently, there are several traditional methods like thrombolysis and mechanical thrombectomy for managing strokes. The curren... |
39852249 | UiO-66 Metal-Organic Framework Membranes: Structural Engineering for Separation Applications. | Metal-organic frameworks (MOFs) have been recognized as promising materials for membrane-based separation technologies due to their exceptional porosity, structural tunability, and chemical stability. This review presents a comprehensive discussion of the advancements in structure engineering and design strategies that... |
39851302 | Deep Learning for Predicting Spheroid Viability: Novel Convolutional Neural Network Model for Automating Quality Control for Three-Dimensional Bioprinting. | Spheroids serve as the building blocks for three-dimensional (3D) bioprinted tissue patches. When larger than 500 μm, the desired size for 3D bioprinting, they tend to have a hypoxic core with necrotic cells. Therefore, it is critical to assess the viability of spheroids in order to ensure the successful fabrication of... |
39851102 | Cyclic Lipopeptides as Selective Anticancer Agents: <i>In vitro</i> Efficacy on B16F10 Mouse Melanoma Cells. | <h4>Objective</h4>In this study, 25 synthetic cyclic lipopeptides (CLPs) were investigated for their anticancer potential against mouse melanoma (B16F10) cells, human prostate cancer (PC-3), human colorectal adenocarcinoma (HT-29) and mouse embryonic fibroblast (NIH3T3) cells.<h4>Methods</h4>The cytotoxic activity of i... |
39850118 | Dietary supplements for prevention of Alzheimer's disease: <i>In vivo</i> and <i>in silico</i> molecular docking studies. | <h4>Objectives</h4>Alzheimer's disease (AD) is one of the most common neurodegenerative diseases in people over 65. The present research aimed to investigate the potential of different dietary supplements (DS) in preventing AD in an experimental animal model and <i>in silico</i> study.<h4>Materials and methods</h4>Thre... |
39842793 | Preparation of a Stable Indomethacin Supersaturated Solution Using Hydrophobically Modified Hydroxypropylmethylcellulose and α-Cyclodextrin. | In the present study, the stability of a supersaturated solution of indomethacin (IM) was evaluated in hydrophobically modified hydroxypropylmethylcellulose (HM-HPMC) solutions, with and without parent cyclodextrins (CDs). A highly supersaturated state of IM was maintained in the HM-HPMC solution and was further stabil... |
39841631 | The Significance of Mono- and Dual-Effective Agents in the Development of New Antifungal Strategies. | Invasive fungal infections (IFIs) pose significant challenges in clinical settings, particularly due to their high morbidity and mortality rates. The rising incidence of these infections, coupled with increasing antifungal resistance, underscores the urgent need for novel therapeutic strategies. Current antifungal drug... |
39841021 | [Neurosteroids as treatment of postpartum depression: a critical literature review]. | <h4>Background</h4>Brexanolone (Zulresso) and zuranolone (Zurzuvae) are two synthetic neuroactive steroids that were approved by the U.S. Food and Drug Administration in March 2019 (as an intravenous treatment) and August 2023 (as an oral treatment) respectively, for the treatment of postpartum depression. To date, the... |
39841528 | <i>Streptococcus suivaginalis</i> sp. nov., <i>Streptococcus iners</i> sp. nov. and <i>Streptococcus iners</i> subsp. <i>hyiners</i> subsp. nov. isolated from pigs. | Three novel strains within the genus <i>Streptococcus</i> (29887<sup>T</sup>, 29892<sup>T</sup> and 29896<sup>T</sup>) were isolated from healthy pigs during routine veterinary physical exams. All three strains were non-motile and non-spore-forming Gram-positive cocci. The complete genome of each strain was attained, a... |
39840831 | Nucleic acid joining enzymes: biological functions and synthetic applications beyond DNA. | DNA-joining by ligase and polymerase enzymes has provided the foundational tools for generating recombinant DNA and enabled the assembly of gene and genome-sized synthetic products. Xenobiotic nucleic acid (XNA) analogues of DNA and RNA with alternatives to the canonical bases, so-called 'unnatural' nucleobase pairs (U... |
39836404 | The Landscape of Vascular Endothelial Growth Factor Inhibition in Retinal Diseases. | Ever since the US Food and Drug Administration (FDA) approved the first vascular endothelial growth factor (VEGF) antagonist 2 decades ago, inhibitors of VEGF have revolutionized the treatment of a variety of ocular disorders involving pathologic neovascularization and retinal exudation. In this perspective, we evaluat... |
39835739 | The Melanocyte and Nerve Fiber Cross-Talk, Facilitated Also by Semaphorin-4A, Enhances UV-B-Induced Melanogenesis. | Epidermal melanocytes form synaptic-like contacts with cutaneous nerve fibers, but the functional outcome of these connections remains elusive. In this pilot study we used our fully humanized re-innervated skin organ culture model to investigate melanocyte-nerve fiber interactions in UV-B-induced melanogenesis. UV-B-ir... |
39835497 | Understanding the Effects of Three Carbohydrate Feeds on the Health of Apis mellifera by Transcriptome Analysis. | At present, there is no clear consensus on the impact of carbohydrate feeds on bee colony health, and comprehensive research and evaluation in this context is lacking. To comprehensively and objectively examine the health status of honeybees after consuming those carbohydrates from multiple perspectives, experimental t... |
39834262 | A Serum D-Fucose Binding Lectin With B Cell Mitogenic Activity From the Grub of the Darkling Beetle Zophobas morio. | Lectins that can recognize and bind to carbohydrates and glycoconjugates are at the epicentre of research owing to their prospective applications. In the present study, a D-fucose binding lectin from the serum of darkling beetle, Zophobas morio was purified and their mitogenic potential over human B-cells was evaluated... |
39834092 | Pathogenic variants of TUBB8 cause oocyte spindle defects by disrupting with EB1/CAKP5 interactions and potential treatment targeting microtubule acetylation through HDAC6 inhibition. | <h4>Background</h4>Numerous pathogenic variants causing human oocyte maturation arrest have been reported on the primate-specific TUBB8 gene. The main etiology is the dramatic reduction of tubulin α/β dimer, but still large numbers of variants remain unexplained.<h4>Methods</h4>Using microinjection mRNA and genome engi... |
39832231 | Chinese yam (Dioscorea opposita Thunb.) starch-ferulic acid complexes: Preparation, characterization, and physicochemical properties. | Polyphenols are known to interact with starch to form the V-type inclusion complex or the noninclusive complex. It is hypothesized that the addition of polyphenols could improve the properties of Chinese yam (Dioscorea opposita Thunb.) starch, and the properties of the complexes could be regulated by controlling the ad... |
39831305 | The SARS-CoV-2 nucleocapsid protein interferes with the full enzymatic activation of UPF1 and its interaction with UPF2. | The nonsense-mediated mRNA decay (NMD) pathway triggers the degradation of defective mRNAs and governs the expression of mRNAs with specific characteristics. Current understanding indicates that NMD is often significantly suppressed during viral infections to protect the viral genome. In numerous viruses, this inhibiti... |
39831308 | Engineered initiator tRNAs can effectively start translation at non-AUG start codons and diversify N-terminal amino acids for mRNA Display. | mRNA display is an effective tool to identify high-affinity macrocyclic binders for challenging protein targets. The success of an mRNA display selection is dependent on generating highly diverse libraries with trillions of peptides. While translation elongation can canonically accommodate the 61 proteinogenic triplet ... |
39829311 | Nanostructural Modulation of G-Quadruplex DNA in Neurodegeneration: Orotate Interaction Revealed Through Experimental and Computational Approaches. | The natural compound orotic acid and its anionic form, orotate, play a pivotal role in various biological processes, serving as essential intermediates in pyrimidine de novo synthesis, with demonstrated connections to dietary, supplement, and neurodrug applications. A novel perspective on biomolecular aggregation at th... |
39829067 | Cytotoxicity of Nanocarrier-Based Drug Delivery in Oral Cancer Therapy: A Systematic Review and Meta-Analysis. | <h4>Background</h4>Oral cancer remains 1 of the biggest health care challenges; it has a poor response to treatment, and treatment often results in severe side effects. Nano-targeted drug carrier-assisted drug delivery systems can improve the benefits of targeted drug delivery and treatment efficacy. A systematic revie... |
39828413 | Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>/GO/HKUST-1 nanocomposite for quercetin extraction and preconcentration followed by its determination using HPLC. | Quercetin, a key flavonoid found in many fruits and vegetables, offers notable health benefits, including antioxidant, antiviral, and antitumor properties. Yet, isolating it from complex plant materials is challenging. This research aimed to develop a selective and efficient sorbent to clean up real sample matrices and... |
39825576 | The Functional and Structural Succession of Mesic-Grassland Soil Microbiomes Beneath Decomposing Large Herbivore Carcasses. | Plant detritus is abundant in grasslands but decomposes slowly and is relatively nutrient-poor, whereas animal carcasses are labile and nutrient-rich. Recent studies have demonstrated that labile nutrients from carcasses can significantly alter the long-term soil microbial function at an ecosystem scale. However, there... |
39817609 | Prognostic Value of Signal Abnormalities on Brain MRI in Post-Anoxic Super-Refractory Status Epilepticus: A Single-Center Retrospective Study. | <h4>Background</h4>Epileptiform activity, including status epilepticus (SE), occurs in up to one-third of comatose survivors of cardiac arrest and may predict poor outcome. The relationship between SE and hypoxic-ischemic brain injury (HIBI) is not established.<h4>Methods</h4>This is a single-center retrospective study... |
39816694 | Transferrin-binding domain inserted-adenovirus hexon engineering enables systemic immune evasion and intratumoral T-cell activation. | <b>Rationale:</b> Adenovirus-based therapies have encountered significant challenges due to host immunity, particularly from pre-existing antibodies. Many trials have struggled to evade antibody response; however, the efficiency of these efforts was limited by the diversity of antibody Fv-region recognizing multiple am... |
39816693 | Hypoxia-responsive nanoparticles for fluorescence diagnosis and therapy of cancer. | Hypoxia, caused by rapid tumor growth and insufficient oxygen supply, is a defining characteristic of numerous solid tumors and exerts a significant influence on tumor growth, metastasis, and invasion. Early diagnosis and effective killing of tumor cells are crucial for cancer treatment. In recent years, the emergence ... |
39816677 | Unveiling urinary extracellular vesicle mRNA signature for early diagnosis and prognosis of bladder cancer. | <b>Background:</b> Bladder cancer (BC) ranks as one of the most prevalent cancers. Its early diagnosis is clinically essential but remains challenging due to the lack of reliable biomarkers. Extracellular vesicles (EVs) carry abundant biological cargoes from parental cells, rendering them as promising cancer biomarkers... |
39815712 | Flaxseed gum nano-microcapsules loaded with secoisolariciresinol diglucoside: Preparation and characterization. | Flaxseed gum (FSG) has promising applications in the field of nano/microencapsulation for its biocompatibility and excellent physicochemical properties. In this study, FSG-based nano-microcapsules (FSG NPs) were prepared using high-speed shear homogenization combined with ultrasound for efficient encapsulation of secoi... |
39815667 | Development of a Recombinant Omicron BA.1 Subunit Vaccine Candidate in Pichia pastoris. | Low-cost and safe vaccines are needed to fill the vaccine inequity gap for future pandemics. Pichia pastoris is an ideal expression system for recombinant protein production due to its cost-effective and easy-to-scale-up process. Here, we developed a next-generation SARS-CoV2 Omicron BA.1-based recombinant vaccine cand... |
39812245 | Flexible framework of computing binding free energy using the energy representation theory of solution. | Host-guest binding plays a crucial role in the functionality of various systems, and its efficiency is often quantified using the binding free energy, which represents the free-energy difference between the bound and dissociated states. Here, we propose a methodology to compute the binding free energy based on the ener... |
39796170 | Mechanism of P-Hydroxy Benzyl Alcohol Against Cerebral Ischemia Based on Metabonomics Analysis. | Stroke is the leading cause of death and disability worldwide, with ischemic stroke accounting for the majority of these. HBA is the active ingredient in <i>Gastrodia elata</i> and has potential therapeutic effects on central nervous system diseases. In this study, the cell model of cerebral ischemia was replicated by ... |
39777764 | Sepsis-induced NET formation requires MYD88 but is independent of GSDMD and PAD4. | Neutrophils are peripheral blood-circulating leukocytes that play a pivotal role in host defense against bacterial pathogens which upon activation, they release web-like chromatin structures called neutrophil extracellular traps (NETs). Here, we analyzed and compared the importance of myeloid differentiation factor 88 ... |
39777470 | Molecular mechanisms underlying allosteric behavior of Escherichia coli DgoR, a GntR/FadR family transcriptional regulator. | GntR/FadR family featuring an N-terminal winged helix-turn-helix DNA-binding domain and a C-terminal α-helical effector-binding and oligomerization domain constitutes one of the largest families of transcriptional regulators. Several GntR/FadR regulators govern the metabolism of sugar acids, carbon sources implicated i... |
39776805 | A specific and adaptable approach to track CD206<sup>+</sup> macrophages by molecular MRI and fluorescence imaging. | <b>Rationale:</b> The mannose receptor (CD206, expressed by the gene <i>Mrc1</i>) is a surface marker overexpressed by anti-inflammatory and pro-tumoral macrophages. As such, CD206<sup>+</sup> macrophages play key roles in the immune response to different pathophysiological conditions and represent a promising diagnost... |
39807702 | Exploring the Relationship Between Humoral and Cellular T Cell Responses Against SARS-CoV-2 in Exposed Individuals From Emilia Romagna Region and COVID-19 Severity. | COVID-19 remains a significant global health problem with uncertain long-term consequences for convalescents. We investigated the relationships between anti-N protein antibody levels, severe acute respiratory syndrome (SARS)-CoV-2-associated TCR repertoire parameters, HLA type and epidemiological information from three... |
39805590 | Chemical biology research in RIKEN NPDepo aimed at agricultural applications. | This review outlines research on chemical biology using mainly microbial metabolites for agricultural applications. We established the RIKEN Natural Products Depository (NPDepo), housing many microbial metabolites, to support academic researchers who focus on drug discovery. We studied methods to stimulate secondary me... |
39804725 | A high-quality assembly revealing the PMEL gene for the unique plumage phenotype in Liancheng ducks. | <h4>Background</h4>Plumage coloration is a distinctive trait in ducks, and the Liancheng duck, characterized by its white plumage and black beak and webbed feet, serves as an excellent subject for such studies. However, academic comprehension of the genetic mechanisms underlying duck plumage coloration remains limited.... |
39804261 | Unveiling the ghost: machine learning's impact on the landscape of virology. | The complexity and speed of evolution in viruses with RNA genomes makes predictive identification of variants with epidemic or pandemic potential challenging. In recent years, machine learning has become an increasingly capable technology for addressing this challenge, as advances in methods and computational power hav... |
39804137 | The Evolving T Cell Receptor Recognition Code: The Rules Are More Like Guidelines. | αβ T cell receptor (TCR) recognition of peptide-MHC complexes lies at the core of adaptive immunity, balancing specificity and cross-reactivity to facilitate effective antigen discrimination. Early structural studies established basic frameworks helpful for understanding and contextualizing TCR recognition and features... |
39804127 | Modulation of Cell Cycle Kinases by Kaposi's Sarcoma-Associated Herpesvirus. | The cell cycle is governed by kinase activity that coordinates progression through a series of regulatory checkpoints, preventing the division of damaged cells. The Kaposi's sarcoma-associated herpesvirus (KSHV) encodes multiple genes that modulate or co-opt the activity of these kinases, shaping the cellular environme... |
39801109 | <i>In silico</i> Evaluation of H1-Antihistamine as Potential Inhibitors of SARS-CoV-2 RNA-dependent RNA Polymerase: Repurposing Study of COVID-19 Therapy. | <h4>Introduction</h4>Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), from the family Coronaviridae, is the seventh known coronavirus to infect humans and cause acute respiratory syndrome. Although vaccination efforts have been conducted against this virus, which emerged in Wuhan, China, in December 2019 a... |
39801089 | Influence of Formulation Composition on the Characteristic Properties of 5-fluorouracil-loaded Liposomes. | <h4>Objectives</h4>Variations in the types and quantities of excipients used to prepare liposomes can affect the physicochemical properties of liposome formulations. This study aimed to provide information about the design and fabrication of 5-fluorouracil (5-FU)-loaded liposome formulations using different lipid and c... |
39800783 | Pulmonary Delivery of Nonviral Nucleic Acid-Based Vaccines With Spotlight on Gold Nanoparticles. | Nucleic acid-based vaccines are leading-edge tools in developing next-generation preventative care. Much research has been done to convert vaccine gene therapy from an invasive to a noninvasive administration approach. The lung's large surface area and permeability make the pulmonary route a promising noninvasive deliv... |
39800364 | Comparison of cell-scaffold interactions in a biological and a synthetic wound matrix. | Wound healing is a central physiological process that restores the barrier properties of the skin after injury, comprising close coordination between several cell types (including fibroblasts and macrophages) in the wound bed. The complex mechanisms involved are executed and regulated by an equally complex, reciprocal ... |
39797733 | Negative DNA supercoiling enhances DARS2 binding of DNA-bending protein IHF in the activation of Fis-dependent ATP-DnaA production. | Oscillation of the active form of the initiator protein DnaA (ATP-DnaA) allows for the timely regulation for chromosome replication. After initiation, DnaA-bound ATP is hydrolyzed, producing inactive ADP-DnaA. For the next round of initiation, ADP-DnaA interacts with the chromosomal locus DARS2 bearing binding sites fo... |
39796372 | Dynamics and Stability Mechanism of Lactoferrin-EPA During Emulsification Process: Insights from Macroscopic and Molecular Perspectives. | Although eicosapentaenoic acid (EPA) as a functional fatty acid has shown significant benefits for human health, its susceptibility to oxidation significantly limits its application. In this study, we developed a nanoemulsion of the lactoferrin (LTF)-EPA complex and conducted a thorough investigation of its macro- and ... |
39796374 | Cold Plasma as a Novel Pretreatment to Improve the Drying Kinetics and Quality of Green Peas. | Green peas, with their high moisture content, require effective drying techniques to extend shelf life while preserving quality. Traditional drying methods face challenges due to the dense structure of the seed coat and wax layer, which limits moisture migration. This study investigates cold plasma (CP) pretreatment as... |
39795500 | A Molecularly Imprinted Electrochemical Sensor for Carbendazim Detection Based on Synergy Amplified Effect of Bioelectrocatalysis and Nanocomposites. | The highly selective and sensitive determination of pesticide residues in food is critical for human health protection. Herein, the specific selectivity of molecularly imprinted polymers (MIPs) was proposed to construct an electrochemical sensor for the detection of carbendazim (CBD), one of the famous broad-spectrum f... |
39795021 | The Effect of <i>Broussonetia papyrifera</i> Silage on the Growth Performance, Blood Physiological Parameters, Serum Biochemical Parameters, Immune Response, Antioxidant Capacity, and Rumen Bacteria of Kazakh Lamb. | Numerous studies have demonstrated that <i>Broussonetia papyrifera</i> is an unconventional feed resource with significant developmental potential. This research aimed to explore the effects of <i>Broussonetia papyrifera</i> silage on the growth performance, blood parameters, immunity, antioxidation, cytokine levels, a... |
39792068 | The Effect of Cholesterol-Loaded Cyclodextrin and Resveratrol Compounds on Post-Thawing Quality of Ram Semen. | Ram sperm are more vulnerable to freezing than those of most other farm animals. During sperm freezing, the cell membrane loses some of its cholesterol, which regulates signalling mechanisms and prevents premature capacitation. Resveratrol (RES) increases the fluidity of the cell membrane, which becomes peroxidized dur... |
39791453 | Principles of ion binding to RNA inferred from the analysis of a 1.55 Å resolution bacterial ribosome structure - Part I: Mg2. | The importance of Mg2+ ions for RNA structure and function cannot be overstated. Several attempts were made to establish a comprehensive Mg2+ binding site classification. However, such descriptions were hampered by poorly modelled ion binding sites as observed in a recent cryo-EM 1.55 Å Escherichia coli ribosome struct... |
39791149 | Emerging Combinatorial Drug Delivery Strategies for Breast Cancer: A Comprehensive Review. | Breast cancer remains the second most prevalent cancer among women in the United States. Despite advancements in surgical, radiological, and chemotherapeutic techniques, multidrug resistance continues to pose significant challenges in effective treatment. Combination chemotherapy has emerged as a promising approach to ... |
39790073 | Neonatal acute liver failure cases with echovirus 11 infections, Japan, August to November 2024. | In 2022-23, several European countries reported paediatric acute liver failure (ALF) with enterovirus infection. In August-November 2024, three neonatal cases of ALF with echovirus 11 (E11) were reported in Tokyo, Japan. All neonates developed irreversible multiple-organ failure and died. The E11 strain belonged to the... |
39788897 | Dynamic Hydrogel-Based Strategy for Traumatic Brain Injury Modeling and Therapy. | Traumatic brain injury (TBI) is one of the most traumatizing and poses serious health risks to people's bodies due to its unique pathophysiological characteristics. The investigations on the pathological mechanism and valid interventions of TBI have attracted widespread attention worldwide. With bio-mimic mechanic cues... |
39788544 | Cu2+ mediates the oxidation of the transcription factor MscA to regulate the antioxidant defense of mycobacteria. | Copper (Cu), a trace element with redox activity, is both essential and toxic to living organisms. Its redox properties make it a cofactor for a variety of proteins, but it also causes oxidative stress, hence the need to maintain intracellular copper homeostasis. However, the role of copper in the regulation of antioxi... |
39788545 | The role of ribosomal protein networks in ribosome dynamics. | Accurate protein synthesis requires ribosomes to integrate signals from distant functional sites and execute complex dynamics. Despite advances in understanding ribosome structure and function, two key questions remain: how information is transmitted between these distant sites, and how ribosomal movements are synchron... |
39786361 | Single-cycle parainfluenza virus type 5 vectors for producing recombinant proteins, including a humanized anti-V5 tag antibody. | Parainfluenza virus type 5 (PIV5) can cause either persistent or acute/lytic infections in a wide range of mammalian tissue culture cells. Here, we have generated PIV5 fusion (F)-expressing helper cell lines that support the replication of F-deleted viruses. As proof of the principle that F-deleted single-cycle infecti... |
39781461 | Caveolin-1 mitigates the advancement of metabolic dysfunction-associated steatotic liver disease by reducing endoplasmic reticulum stress and pyroptosis through the restoration of cholesterol homeostasis. | Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease worldwide, which has the potential to advance to fibrosis. CAV1 has the effects of improving liver lipid deposition in MASLD, however, the potential mechanism is largely unknown. Here, we establish a MASLD mouse... |
39781354 | Sensitivity of renal cell carcinoma to cuproptosis: a bioinformatics analysis and experimental verification. | <b>Purpose:</b> Targeting cuproptosis is considered as a promising therapeutic strategy for the prevention of tumors. However, the potential role of cuproptosis and its related genes in clear cell renal cell carcinoma (ccRCC) remains elusive. The present study aims to explore the sensitivity of ccRCC to cuproptosis and... |
39780947 | Process-based screening of porous materials for vacuum swing adsorption based on 1D classical density functional theory and PC-SAFT. | Adsorption-based processes are showing substantial potential for carbon capture. Due to the vast space of potential solid adsorbents and their influence on the process performance, the choice of the material is not trivial but requires systematic approaches. In particular, the material choice should be based on the per... |
39779363 | Ajwa date extract (<i>Phoenix dactylifera L.</i>): Phytochemical analysis, antiviral activity against herpes simplex virus-I and coxsackie B4 virus, and in silico study. | <h4>Objectives</h4>To investigate the phytochemical composition of Ajwa date extract and evaluate its antiviral activity and mechanism of action.<h4>Methods</h4>High perfomance liquid chromatography, gas chromatography-mass spectrometry, and liquid chromatography-mass spectrometry were used to analyze the phytochemical... |
39778006 | The role of acetylation and deacetylation in cancer metabolism. | As a hallmark of cancer, metabolic reprogramming adjusts macromolecular synthesis, energy metabolism and redox homeostasis processes to adapt to and promote the complex biological processes of abnormal growth and proliferation. The complexity of metabolic reprogramming lies in its precise regulation by multiple levels ... |
39777699 | Tubulin-Binding Region Modulates Cholesterol-Triggered Aggregation of Tau Proteins. | A hallmark of Alzheimer disease (AD) and tauopathies, severe neurodegenerative diseases, is the progressive aggregation of Tau, also known as microtubule-associated Tau protein. Full-length Tau<sub>1-441</sub>, also known as 2N4R, contains two N-terminal inserts that bind to tubulin. This facilitates the self-assembly ... |
39777463 | Unveiling the unusual i-motif-derived architecture of a DNA aptamer exhibiting high affinity for influenza A virus. | Non-canonical nucleic acid structures play significant roles in cellular processes through selective interactions with proteins. While both natural and artificial G-quadruplexes have been extensively studied, the functions of i-motifs remain less understood. This study investigates the artificial aptamer BV42, which bi... |
39776812 | Advances in adhesive hydrogels applied for ophthalmology: An overview focused on the treatment. | Adhesive hydrogels, composed of hydrophilic polymers arranged in a three-dimensional network, have emerged as a pivotal innovation in ophthalmology due to their ability to securely adhere to ocular tissues while providing sustained therapeutic effects. The eye, with its delicate structure and specific needs, presents u... |
39776807 | RNA nanotherapeutics for hepatocellular carcinoma treatment. | Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, particularly due to the limited effectiveness of current therapeutic options for advanced-stage disease. The efficacy of traditional treatments is often compromised by the intricate liver microenvironment and the inherent hete... |
39776808 | Ultra-small quercetin-based nanotherapeutics ameliorate acute liver failure by combatting inflammation/cellular senescence cycle. | <b>Background:</b> Acute liver failure (ALF) is marked by a substantial generation of reactive oxygen species (ROS), which can induce both cellular senescence and a pronounced inflammatory response. Senescent cells secrete factors collectively termed the senescence-associated secretory phenotype (SASP), which exacerbat... |
39776802 | Optical molecular imaging technology and its application in precise surgical navigation of liver cancer. | Recent innovations in medical imaging technology have placed molecular imaging techniques at the forefront of diagnostic advancements. The current research trajectory in this field aims to integrate personalized molecular data of patients and diseases with traditional anatomical imaging data, enabling more precise, non... |
39776796 | A general strategy towards activatable nanophotosensitizer for phototoxicity-free photodynamic therapy. | <b>Background:</b> Photodynamic therapy (PDT) has gained widespread attention in cancer treatment, but it still faces clinical problems such as skin phototoxicity. Activatable photosensitizers offer a promising approach to addressing this issue. However, several significant hurdles need to be overcome, including develo... |
39776792 | Drug repositioning of mesalamine via supramolecular nanoassembly for the treatment of drug-induced acute liver failure. | <b>Rationale:</b> Acute liver failure (ALF) is characterized by rapid hepatic dysfunction, primarily caused by drug-induced hepatotoxicity. Due to the lack of satisfactory treatment options, ALF remains a fatal clinical disease, representing a grand challenge in global health. <b>Methods:</b> For the drug repositioning... |
39776638 | Crystal structure and Hirshfeld surface analysis of 1,3,3,4,4,5,5-hepta-fluoro-2-(3-[(2,3,3,4,4,5,5-hepta-fluoro-cyclo-penten-1-yl)-oxy]-2-{[(2,3,3,4,4,5,5-hepta-fluoro-cyclo-penten-1-yl)-oxy]meth-yl}-2-methyl-prop-oxy)cyclo-pentene. | In the title compound, C<sub>20</sub>H<sub>9</sub>F<sub>21</sub>O<sub>3</sub>, a central <i>sp</i> <sup>3</sup>-hybridized carbon atom is decorated with three hepta-fluoro-2-meth-yloxy(cyclo-pent-1-ene) arms and a methyl group. The primary packing is determined by C-F⋯F-C inter-actions, forming [001] chains, which are ... |
39776633 | Synthesis and crystal structure of <i>anti</i>-10-(4-cyano-phen-yl)-10,11,22,23-tetra-hydro-9<i>H</i>,21<i>H</i>-5,8:15,12-bis-(metheno)[1,5,11]tri-aza-cyclo-hexadecino[1,16-<i>a</i>:5,6-<i>a</i>']di-indole di-chloro-methane monosolvate. | The asymmetric unit of the title compound is composed of one host mol-ecule, <i>anti</i>-4-(1<sup>9</sup> <i>H</i>,5<sup>9</sup> <i>H</i>-3-aza-1,5(3,9)-dicarbazola-cyclo-octa-phane-3-yl)benzo-nitrile and one di-chloro-methane solvate mol-ecule, C<sub>36</sub>H<sub>28</sub>N<sub>4</sub>·CH<sub>2</sub>Cl<sub>2</sub>. Th... |
39776491 | Advances of Stimuli-Responsive Amphiphilic Copolymer Micelles in Tumor Therapy. | Amphiphilic copolymers are composed of both hydrophilic and hydrophobic chains, which can self-assemble into polymeric micelles in aqueous solution via the hydrophilic/hydrophobic interactions. Due to their unique properties, polymeric micelles have been widely used as drug carriers. Poorly soluble drugs can be covalen... |
39776353 | DetectEV: A functional enzymatic assay to assess integrity and bioactivity of extracellular vesicles. | The application of extracellular vesicles (EVs) as therapeutics or nanocarriers in cell-free therapies necessitates meticulous evaluations of different features, including their identity, bioactivity, batch-to-batch reproducibility, and stability. Given the inherent heterogeneity in EV preparations, this assessment dem... |
39776289 | Clozapine Induces Agranulocytosis via Inflammatory and Hematopoietic Cytokine Induction of the JAK-STAT Signaling Pathway: Evidence From Network Pharmacology and Molecular Docking. | <h4>Background</h4>Clozapine exhibits significant therapeutic efficacy in schizophrenia, especially treatment-resistant schizophrenia. However, clozapine can cause agranulocytosis, a fatal adverse effect, and the aim of this study is to explore this mechanism based on network pharmacology and molecular docking.<h4>Meth... |
39774894 | Open-boundary molecular dynamics of ultrasound using supramolecular water models. | Ultrasound can be used to manipulate protein function and activity, as well as for targeted drug delivery, making it a powerful diagnostic and therapeutic modality with wide applications in sonochemistry, nanotechnology, and engineering. However, a general particle-based approach to ultrasound modeling remains challeng... |
39774888 | Nanoscale self-assembly and water retention properties of silk fibroin-riboflavin hydrogel. | Silk-fibroin hydrogels have gained considerable attention in recent years for their versatile biomedical applications. The physical properties of a complex hydrogel, comprising silk fibroin and riboflavin, surpass those of the silk fibroin-hydrogel without additives. This study investigates silk fibroin-riboflavin (sil... |
39774671 | Neuro-Behçet's disease: an update of clinical diagnosis, biomarkers, and immunopathogenesis. | Neuro-Behçet's disease (NBD) is a more severe but rare symptom of Behçet's disease, which is mainly divided into parenchymal NBD (p-NBD) involving brain stem, spinal cord, and cerebral cortex. Non-p-NBD manifests as intracranial aneurysm, cerebral venous thrombosis, peripheral nervous system injuries, and mixed parench... |
39763069 | Disturbed shear stress promotes atherosclerosis through TRIM21-regulated MAPK6 degradation and consequent endothelial inflammation. | <h4>Rationale</h4>Coronary artery plaques often develop in regions subjected to disturbed shear stress (DSS), yet the mechanisms underlying this phenomenon remain poorly understood. Our study aimed to elucidate the unknown role of MAPK6 in shear stress and plaque formation.<h4>Methods</h4>In vitro and in vivo experimen... |
39763011 | Unprecedented carbonic anhydrase inhibition mechanism: Targeting histidine 64 side chain through a halogen bond. | 2,2'-Thio-bis(4,6-dichlorophenol), namely bithionol, is a small molecule endowed with a multifaceted bioactivity. Its peculiar polychlorinated phenolic structure makes it a suitable candidate to explore its potentialities in establishing interaction patterns with enzymes of MedChem interest, such as the human carbonic ... |
39757603 | Formulation, Characterization and Cytotoxic Effect of Indomethacin-loaded Nanoparticles. | <h4>Background</h4>Indomethacin (IND), classified as class 2 in the Biopharmaceutical Classification System (BCS), has emerged as an anti-inflammatory agent with low solubility and high permeability. Widely used in the treatment of various diseases, such as rheumatoid arthritis and ankylosing spondylitis, this drug is ... |
39756988 | Preparation and Structural Properties of Gel Coating Films Containing Lipophilized Nanocarbon Particles Functionalized with Thixotropic Chains. | Gel coating films comprising nanodiamonds organo-modified with 12-hydroxystearic (12-OHC<sub>18</sub> ) and stearic acids were prepared and characterized. Because molecules with 12-OHC<sub>18</sub> groups can convert solvents into thixotropic gels, Gemini-type diamide derivatives with two 12-OHC<sub>18</sub> chains wer... |
39756354 | Exploring the drug delivery capabilities of Nb<sub>2</sub>C MXene functionalized with oxygen and fluorine: A DFT study. | MXenes quantum dots (QDs), including Nb<sub>2</sub>C, Nb<sub>2</sub>CO<sub>2</sub>, and Nb<sub>2</sub>CF<sub>2</sub>, are emerging materials with exceptional structural, electronic, and optical properties, making them highly suitable for biomedical applications. This study investigates the structural optimization, stab... |
39755952 | A twofold interpenetrated three-dimensional barium(II) metal-organic framework constructed from 2,2'-[terephthaloylbis(azanediyl)]diacetate: synthesis, structure, dihydrogen bonding and spectroscopic properties. | A new twofold interpenetrated 3D metal-organic framework (MOF), namely, poly[[μ-aqua-diaqua{μ<sub>4</sub>-2,2'-[terephthaloylbis(azanediyl)]diacetato}barium(II)] dihydrate], {[Ba(C<sub>12</sub>H<sub>10</sub>N<sub>2</sub>O<sub>6</sub>)(H<sub>2</sub>O)<sub>3</sub>]·2H<sub>2</sub>O}<sub>n</sub>, (I), has been assembled th... |
39746215 | Deciphering Saquinavir-Bovine Serum Albumin Interactions: Spectroscopic and Computational Insights. | Bovine serum albumin (BSA) plays a crucial role as a carrier protein in plasma, binding various ligands, including drugs. Understanding the interaction between BSA and saquinavir, an antiretroviral drug, is essential for predicting its pharmacokinetics and pharmacodynamics. We employed spectroscopic approaches, includi... |
39744691 | Recent advances in ferrocene-based nanomedicines for enhanced chemodynamic therapy. | Malignant tumors have been a serious threat to human health with their increasing incidence. Difficulties with conventional treatments are toxicity, drug resistance, and recurrence. For this reason, non-invasive treatment modalities such as photothermal therapy (PTT), photodynamic therapy (PDT), chemodynamic therapy (C... |
39744697 | Advancements in GelMA bioactive hydrogels: Strategies for infection control and bone tissue regeneration. | Infectious bone defects present a significant clinical challenge, characterized by infection, inflammation, and subsequent bone tissue destruction. Traditional treatments, including antibiotic therapy, surgical debridement, and bone grafting, often fail to address these defects effectively. However, recent advancements... |
39744693 | Silk fibroin-based hydrogels for cartilage organoids in osteoarthritis treatment. | Osteoarthritis (OA) is a common joint disease characterized by cartilage degeneration. It can cause severe pain, deformity and even amputation risk. However, existing clinical treatment methods for cartilage repair present certain deficiencies. Meanwhile, the repair effect of cartilage tissue engineering is also unsati... |
39744687 | MRI guided copper deprivator activated immune responses and suppressed angiogenesis for enhanced antitumor immunotherapy. | <b>Background:</b> Copper plays an important role in the regulation of PD-L1, suggesting that reducing copper levels within tumors may enhance anti-cancer immunotherapy. <b>Methods:</b> Tumor microenvironment responsive copper nanodeprivator (TMECN) was developed for enhancing immunotherapy of tumor via the cross-link ... |
39744680 | Standardization and consensus in the development and application of bone organoids. | Organoids, self-organized structures derived from stem cells cultured in a specific three-dimensional (3D) <i>in vitro</i> microenvironment, have emerged as innovative platforms that closely mimic <i>in vivo</i> cellular behavior, tissue architecture, and organ function. Bone organoids, a frontier in organoid research,... |
39744573 | Demethylzeylasteral inhibits oxidative phosphorylation complex biogenesis by targeting LRPPRC in lung cancer. | Targeted inhibition of mitochondrial oxidative phosphorylation (OXPHOS) complex generation is an emerging and promising cancer treatment strategy, but limited targets and specific inhibitors have been reported. Leucine-rich pentatricopeptide repeat-containing protein (LRPPRC) is an atypical RNA-binding protein that reg... |
39744515 | Non-spike protein inhibition of SARS-CoV-2 by natural products through the key mediator protein ORF8. | The recent pernicious COVID-19 pandemic is caused by SARS-CoV-2. While most therapeutic strategies have focused on the viral spike protein, Open Reading Frame 8 (ORF8) plays a critical role in causing the severity of the disease. Nonetheless, there still needs to be more information on the ORF8 binding epitopes and the... |
39744500 | Cell-type-specific regulators landscape and regulatory mechanisms underlying pyroptosis in uterine corpus endometrial carcinoma. | <b>Background</b>: Endometrial cancer (UCEC) has a significant detrimental effect on patient quality of life. Although pyroptosis-related genes have been reported to contribute to tumor pathogenesis, the specific mechanism of pyroptosis in patients with UCEC remains elusive. <b>Methods:</b> We provide an overview of th... |
39744438 | Targeting protein modification: a new direction for immunotherapy of pancreatic cancer. | Post-translational modifications (PTMs) alter protein conformation by covalently attaching functional groups to substrates, influencing their biological activity, mechanisms of action, and functional performance. PTMs and their interactions are essential to many critical signal transduction processes, including tumor t... |
39744235 | iRGD-TRP-PK1-modified red blood cell membrane vesicles as a new chemotherapeutic drug delivery and targeting system in head and neck cancer. | <b>Background:</b> Chemotherapy is essential for treating tumors, including head and neck cancer (HNC). However, the toxic side effects of chemotherapeutic drugs limit their widespread use. Therefore, a targeted delivery system that can transport the drug to the pathological site while minimizing damage to healthy tiss... |
39744228 | Targeting cancer with precision: strategical insights into TCR-engineered T cell therapies. | T cell receptor-engineered T (TCR-T) cell therapies are at the forefront of cancer immunotherapy, offering a transformative approach that significantly enhances the ability of T cells to recognize and eliminate cancer cells. This innovative method involves genetically modifying TCRs to increase their affinity for tumor... |
39744221 | Leveraging plant-derived nanovesicles for advanced nucleic acid-based gene therapy. | Gene therapy has evolved into a pivotal approach for treating genetic disorders, extending beyond traditional methods of directly repairing or replacing defective genes. Recent advancements in nucleic acid-based therapies-including mRNA, miRNA, siRNA, and DNA treatments have expanded the scope of gene therapy to includ... |
39743779 | Amelogenin-Derived Peptide-Modified Poly(amidoamine) Dendrimers for Root Caries Prevention. | Root caries present a significant challenge in dentistry. The unsatisfactory prognosis of restorative treatments requires novel, noninvasive preventive strategies. Here, we developed an amelogenin-derived peptide-modified poly(amidoamine), PAMAM-C11, to prevent demineralization in caries lesions and control periodontal... |
39743670 | Identification of the MAP4K gene family reveals GhMAP4K13 regulates drought and salt stress tolerance in cotton. | Mitogen-activated protein kinase kinase kinase kinases (MAP4Ks) are a class of highly conserved serine/threonine-protein kinases in eukaryotes. They participate in the typical MAPK cascade system and various signal transduction pathways regulating biological processes in plants, during stressful conditions. To date, ge... |
39743667 | Interfacial Engineering of Pillared Co(II) Metal-Organic Framework@NiMn-Layered Double Hydroxide Nanocomposite for Oxygen Evolution Reaction Electrocatalysis. | Clean energy conversion and storage require simple, economical, and effective electrode materials to achieve promising results. The development of high-performance electrocatalysts with adequate stability and cost-effectiveness is essential to ensure low overpotentials toward the oxygen evolution reaction (OER). Herein... |
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