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39747169 | Spectroscopic, quantum chemical, and topological calculations of the phenylephrine molecule using density functional theory. | In this work, Density Functional Theory (DFT) on Gaussian 09 W software was utilized to investigate the phenylephrine (PE) molecule (C9H13NO2). Firstly, the optimized structure of the PE molecule was obtained using B3LYP/6-311 + G (d, p) and CAM-B3LYP/6-311 + G (d, p) basis sets. The electron charge density is shown in... |
39747148 | A noncanonical role of roX RNAs in autosomal epigenetic repression. | Long noncoding RNAs known as roX (RNA on the X) are crucial for male development in Drosophila, as their loss leads to male lethality from the late larval stages. While roX RNAs are recognized for their role in sex-chromosome dosage compensation, ensuring balanced expression of X-linked genes in both sexes, their poten... |
39747146 | Spin polarization induced by atomic strain of MBene promotes the ·O<sub>2</sub><sup>-</sup> production for groundwater disinfection. | Superbugs in groundwater are posing severe health risks through waterborne pathways. An emerging approach for green disinfection lies at photocatalysis, which levers the locally generated superoxide radical (·O<sub>2</sub><sup>-</sup>) for neutralization. However, the spin-forbidden feature of O<sub>2</sub> hinders the... |
39747131 | A cross-entropy corrected hybrid multiconfiguration pair-density functional theory for complex molecular systems. | Hybrid density functionals, such as B3LYP and PBE0, have achieved remarkable success by substantially improving over their parent methods, namely Hartree-Fock and the generalized gradient approximation, and generally outperforming the second-order Møller-Plesset perturbation theory (MP2) that is more expensive. Here, w... |
39747121 | Hypoxia-tolerant polymeric photosensitizer prodrug for cancer photo-immunotherapy. | Although photodynamic immunotherapy represents a promising therapeutic approach against malignant tumors, its efficacy is often hampered by the hypoxia and immunosuppressive conditions within the tumor microenvironment (TME) following photodynamic therapy (PDT). In this study, we report the design guidelines towards ef... |
39747118 | Crystal structure of Au-pseudocarbyne(C<sub>6</sub>). | Carbyne-related materials permit exploring the potentially extraordinary properties of this long-sought but still elusive carbon allotrope. However, accurate understanding of these materials is challenging. Here we report the crystal structure of a Au-pseudocarbyne, a representative of a possible new family of material... |
39747115 | Structural insights into the regulation of monomeric and dimeric apelin receptor. | The apelin receptor (APJR) emerges as a promising drug target for cardiovascular health and muscle regeneration. While prior research unveiled the structural versatility of APJR in coupling to Gi proteins as a monomer or dimer, the dynamic regulation within the APJR dimer during activation remains poorly understood. In... |
39747106 | Engineering 2D spin networks by on-surface encapsulation of azafullerene radicals in nanotemplates. | We present an efficient strategy for on-surface engineering of organic metal-free supramolecular complexes with long-term spin protection. By vacuum deposition of azafullerene (C<sub>59</sub>N<sup>•</sup>) monomers on a pre-deposited template layer of [10]cycloparaphenylene ([10]CPP) nanohoops on Au(111) surface we exp... |
39747065 | Acquisition of Fc-afucosylation of PfEMP1-specific IgG is age-dependent and associated with clinical protection against malaria. | Protective immunity to malaria depends on acquisition of parasite-specific antibodies, with Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) being one of the most important target antigens. The effector functions of PfEMP1-specific IgG include inhibition of infected erythrocyte (IE) sequestration and opson... |
39747053 | Titanium nitride sensor for selective NO<sub>2</sub> detection. | Efficient detection methods are needed to monitor nitrogen dioxide (NO<sub>2</sub>), a major NO<sub>x</sub> pollutant from fossil fuel combustion that poses significant threats to both ecology and human health. Current NO<sub>2</sub> detection technologies face limitations in stability and selectivity. Here, we present... |
39747047 | Self-assembled materials with an ordered hydrophilic bilayer for high performance inverted Perovskite solar cells. | While self-assembled material based inverted perovskite solar cells have surpassed power conversion efficiencies of 26%, enhancing their performance in large-area configurations remains a significant challenge. In this work, we report a self-assembled material based hole-selective layer 4-(7H-dibenzo[c,g]carbazol-7-yl)... |
39747042 | Compressible, anti-fatigue, extreme environment adaptable, and biocompatible supramolecular organohydrogel enabled by lignosulfonate triggered noncovalent network. | Achieving a synergy of biocompatibility and extreme environmental adaptability with excellent mechanical property remains challenging in the development of synthetic materials. Herein, a "bottom-up" solution-interface-induced self-assembly strategy is adopted to develop a compressible, anti-fatigue, extreme environment... |
39747031 | Nitrile-aminothiol bioorthogonal near-infrared fluorogenic probes for ultrasensitive in vivo imaging. | Bioorthogonal chemistry-mediated self-assembly holds great promise for dynamic molecular imaging in living organisms. However, existing approaches are limited to nanoaggregates with 'always-on' signals, suffering from high signal-to-background ratio (SBR) and compromised detection sensitivity. Herein we report a nitril... |
39747028 | A stable and biocompatible shortwave infrared nanoribbon for dual-channel in vivo imaging. | The shortwave infrared (SWIR) region is an ideal spectral window for next-generation bioimaging to harness improved penetration and reduced phototoxicity. SWIR spectral activity may also be accessed via supramolecular dye aggregation. Unfortunately, development of dye aggregation remains challenging. We propose a cryst... |
39747011 | Multi-modal conditional diffusion model using signed distance functions for metal-organic frameworks generation. | The design of porous materials with user-desired properties has been a great interest for the last few decades. However, the flexibility of target properties has been highly limited, and targeting multiple properties of diverse modalities simultaneously has been scarcely explored. Furthermore, although deep generative ... |
39747007 | Anti-dendrite separator interlayer enabling staged zinc deposition for enhanced cycling stability of aqueous zinc batteries. | Aqueous zinc ion batteries exhibit great prospects due to their low cost and high safety, while their lifespan is limited by severe dendritic growth problems. Herein, we develop an anti-dendrite hot-pressing separator interlayer through a mass-producible hot-pressing strategy, by spreading metal-organic framework (MOF)... |
39747000 | Probing SARS-CoV-2 membrane binding peptide via single-molecule AFM-based force spectroscopy. | The SARS-CoV-2 spike protein's membrane-binding domain bridges the viral and host cell membrane, a critical step in triggering membrane fusion. Here, we investigate how the SARS-CoV-2 spike protein interacts with host cell membranes, focusing on a membrane-binding peptide (MBP) located near the TMPRSS2 cleavage site. T... |
39746984 | Pt/IrO<sub>x</sub> enables selective electrochemical C-H chlorination at high current. | Employing electrochemistry for the selective functionalization of liquid alkanes allows for sustainable and efficient production of high-value chemicals. However, the large potentials required for C(sp<sup>3</sup>)-H bond functionalization and low water solubility of such alkanes make it challenging. Here we discover t... |
39746978 | Coordinatively stiffen and toughen polymeric gels via the synergy of crystal-domain cross-linking and chelation cross-linking. | Polymer gels have been widely used in flexible electronics, soft machines and impact protection materials. Conventional gels usually suffer from the inherent conflict between stiffness and toughness, severely hampering their applications. This work proposes a facile yet versatile strategy to break through this trade-of... |
39746981 | Molecular properties of the RmlT wall teichoic acid rhamnosyltransferase that modulates virulence in Listeria monocytogenes. | Wall teichoic acids (WTAs) from the major Gram-positive foodborne pathogen Listeria monocytogenes are peptidoglycan-associated glycopolymers decorated by monosaccharides that, while not essential for bacterial growth, are required for bacterial virulence and resistance to antimicrobials. Here we report the structure an... |
39746976 | A new class of natural anthelmintics targeting lipid metabolism. | Parasitic helminths are a major global health threat, infecting nearly one-fifth of the human population and causing significant losses in livestock and crops. Resistance to the few anthelmintic drugs is increasing. Here, we report a set of avocado fatty alcohols/acetates (AFAs) that exhibit nematocidal activity agains... |
39746970 | Modulating synaptic plasticity with metal-organic framework for information-filterable artificial retina. | Neuroprosthetics equipped with artificial synapses hold promise to address some most intricate medical problems, such as human sensory disorders. Yet, it is necessitated and of paramount importance for neuroprosthetics to be able to differentiate significant and insignificant signals. Here, we present an information-fi... |
39746959 | Engineering spatially-confined conduits to tune nerve self-organization and allodynic responses via YAP-mediated mechanotransduction. | Chronic allodynia stemming from peripheral stump neuromas can persist for extended periods, significantly compromising patients' quality of life. Conventional managements for nerve stumps have demonstrated limited effectiveness in ensuring their orderly termination. In this study, we present a spatially confined condui... |
39746956 | Supramolecular modification of sustainable high-molar-mass polymers for improved processing and performance. | The plastic waste crisis is among humanity's most urgent challenges. However, widespread adoption of sustainable plastics is hindered by their often inadequate processing characteristics and performance. Here, we introduce a bio-inspired strategy for the modification of a representative high molar mass, biodegradable a... |
39746955 | Carbene-catalyzed chirality-controlled site-selective acylation of saccharides. | Acylation stands as a fundamental process in both biological pathways and synthetic chemical reactions, with acylated saccharides and their derivatives holding diverse applications ranging from bioactive agents to synthetic building blocks. A longstanding objective in organic synthesis has been the site-selective acyla... |
39746663 | Tuning Bro̷nsted Acidity by up to 12 p<i>K</i><sub>a</sub> Units in a Redox-Active Nanopore Lined with Multifunctional Metal Sites. | Electrostatic interactions, hydrogen bonding, and solvation effects can alter the free energies of ionizable functional groups in proteins and other nanoporous architectures, allowing such structures to tune acid-base chemistry to support specific functions. Herein, we expand on this theme to examine how metal sites (<... |
39746105 | Nomadic Nanomedicines: Medicines Enabled by the Paracrine Transfer Effect. | In nanomedicine, the cellular export of nanomaterials has been less explored than uptake. Traditionally viewed in a negative light, recent findings highlight the potential of nanomedicine export to enhance therapeutic effects. This Perspective examines key pathways for export and how nanomaterial design affects removal... |
39746035 | Metal Ion Signaling in Biomedicine. | Complex multicellular organisms are composed of distinct tissues involving specialized cells that can perform specific functions, making such life forms possible. Species are defined by their genomes, and differences between individuals within a given species directly result from variations in their genetic codes. Whil... |
39746020 | Self-Assembled Piezoelectric Films from Aligned Lysozyme Protein Fibrils. | Piezoelectric organic polymers are promising alternatives to their inorganic counterparts due to their mechanical flexibility, making them suitable for flexible and wearable piezoelectric devices. Biological polymers such as proteins have been reported to possess piezoelectricity, while offering additional benefits, su... |
39745995 | Convergent Protocols for Computing Protein-Ligand Interaction Energies Using Fragment-Based Quantum Chemistry. | Fragment-based quantum chemistry methods offer a means to sidestep the steep nonlinear scaling of electronic structure calculations so that large molecular systems can be investigated using high-level methods. Here, we use fragmentation to compute protein-ligand interaction energies in systems with several thousand ato... |
39745926 | N-Doped Zigzag-Type Aromatic Truncated Cone Belts. | Zigzag aromatic hydrocarbon belts, ultrashort segments of zigzag carbon nanotubes, have been fascinating in the chemistry community for more than a half century because of their aesthetically appealing molecular nanostructures and tantalizing applications. Precise introduction of heteroatoms of distinct electronegativi... |
39745599 | Programmable Food-Derived Peptide Coassembly Strategies for Boosting Targeted Colitis Therapy by Enhancing Oral Bioavailability and Restoring Gut Microenvironment Homeostasis. | Orally targeting nanostrategies of multiple nutraceuticals have attracted increasing attention in ulcerative colitis (UC) therapy for superior patient compliance, cost-effectiveness, and biocompatibility. However, the actual targeting delivery and bioefficacy of nutraceuticals are extremely restricted by their poor sol... |
39745491 | Sustainable Formation of Gold Nanoparticle-Decorated Amyloid Fibrils for the Development of Functional Hybrid Materials. | Amyloid fibrils have recently emerged as promising building blocks for functional materials due to their exceptional physicochemical stability and adaptable properties. These protein-based structures can be functionalized to create hybrid materials with a diverse range of applications. Here we report a simple eco-frien... |
39745392 | Plasmon-Enhanced Fluorescence Based on Gold Nanobipyramids with PEG-Controlled Distance for Near-Infrared and Visual Analysis of Amyloid-β Aggregation. | The number of cases of Alzheimer's disease (AD) characterized by progressive amnestic syndrome is dramatically increased with population aging. It is urgent to detect and diagnose this disease early. The state of amyloid-beta protein 1-42 (Aβ<sub>42</sub>) was commonly regarded as a hallmark for early diagnosis of AD. ... |
39745294 | Two-Dimensional Layer {P<sub>4</sub>Mo<sub>6</sub>} Clusters Constructed with N-Ligands for Bifunctional Properties of Proton Conduction and Supercapacitors. | Proton exchange membrane fuel cells (PEMFCs) are developing into very meaningful clean energy to fundamentally address environmental pollution. Among which the most studied Nafion series membranes are limited under large-scale use, and some strong oxidizing groups such as hydrogen peroxide will attack the structure of ... |
39745248 | Chiral Membrane Containing Subnanometer Channels for Enantioselective Transport Amino Acids. | The research of chiral separation technology is of great significance for understanding the origin of life and promoting the application of chiral molecules. Herein, anionic chiral pillar[6]arene and cationic pillar[6]arene were designed and synthesized, and a chiral pillar[6]arene membrane was constructed by layer-by-... |
39745136 | Optical Bionanosensors for Sepsis Diagnostics. | Sepsis is a global health challenge, characterized by a dysregulated immune response, leading to organ dysfunction and death. Despite advances in medical care, sepsis continues to claim a significant toll on human lives, with mortality rates from 10-25% for sepsis and 30-50% for septic shock, making it a leading cause ... |
39745140 | Molecular Sensing of Chiral Carboxylic Acid Enantiomers Using CD Inductions in the Visible Light Region. | The reaction between a chiral carboxylic acid molecule and 1,1'-bis(diphenylphosphino)ferrocenepalladium dichloride in the presence of a mild base generates a chiroptically active metal complex displaying strong circular dichroism (CD) signals in the visible light region, a highly sought-after goal in the optical sensi... |
39745117 | Engineering CAR-T Therapeutics for Enhanced Solid Tumor Targeting. | Cancer immunotherapy, specifically Chimeric Antigen Receptor (CAR)-T cell therapy, represents a significant breakthrough in treating cancers. Despite its success in hematological cancers, CAR-T exhibits limited efficacy in solid tumors, which account for more than 90% of all cancers. Solid tumors commonly present uniqu... |
39745081 | Anthracene-Conjugated Steroidal Amphiphiles: Soft Functional Materials Exhibiting Supramolecular Aggregation Induced Enhanced Emission with Potential Applications as Drug Carriers and Fluorescent Bioprobes. | Bile salts (BS) are naturally occurring steroidal biosurfactants. The ease of functionalization of BSs has boosted their use as inexpensive building blocks for the fabrication of a broad set of value-added soft functional materials. In the present work, three fluorescent bile acid (FBA) derivatives have been synthesize... |
39745069 | Characterization of global research trends and prospects on celastrol, a principal bioactive ingredient of <i>Tripterygium wilfordii</i> Hook F: bibliometric analysis. | <h4>Context</h4>Celastrol, acknowledged as a prominent exemplar of the potential for transforming traditional medicinal compounds into contemporary pharmaceuticals, has garnered considerable attention owing to its extensive pharmacological activities. The increasing volume of publications concerning celastrol highlight... |
39745057 | Electrochemical Self-Sacrificial Label Conversion Coupled with DNA Framework Nanomachine Mediated Serotonin Sensing with Highly Minimized Background Noise. | Conventional solid/liquid electrochemical interfaces typically encounter challenges with impeded mass transport for poor electrochemical quantification due to the intricate pathways of reactants from the bulk solution. To address this issue, this work reports an innovative approach integrating a target-activated DNA fr... |
39745053 | An Ultramicroporous Physisorbent Sustained by a Trifecta of Directional Supramolecular Interactions. | 2D and 3D porous coordination networks (PCNs) as exemplified by metal-organic frameworks, MOFs, have garnered interest for their potential utility as sorbents for molecular separations and storage. The inherent modularity of PCNs has enabled the development of crystal engineering strategies for systematic fine-tuning o... |
39744782 | Boosting Hot Electron Generation in Energy Center Embedded Metal-Organic Frameworks for Photocatalysis. | The ligands in metal-organic framework (MOF) play as light absorption center and transfer photogenerated electrons to metal node through ligand-to-metal charge transfer (LMCT) during photocatalysis, and energy utilization efficiency is strongly restricted by the light inertness of ligands. Herein, a ligand updating str... |
39744759 | Slide-Ring Structured Stress-Electric Coupling Hydrogel Microspheres for Low-Loss Transduction Between Tissues. | High transductive loss at tissue injury sites impedes repair. The high dissipation characteristics in the electromechanical conversion of piezoelectric biomaterials pose a challenge. Therefore, supramolecular engineering and microfluidic technology is utilized to introduce slide-ring polyrotaxane and conductive polypyr... |
39743957 | Glutathione-Driven Disassembly of Planar Organic Phototherapeutic Agents to Enhance Photodynamic-Photothermal Therapy Performance for Nasopharyngeal Carcinoma. | The self-assembly of hydrophobic organic phototherapeutic agents (OPTAs) with expansive planar structures into nanoparticles (NPs) represents a pivotal strategy to bolster their biocompatibility. However, the tight molecular packing within these NPs significantly influences the generation of reactive oxygen species (RO... |
39743616 | JHU-2545 preferentially shields salivary glands and kidneys during PSMA-targeted imaging. | <h4>Purpose</h4>Prostate-specific membrane antigen (PSMA) radioligand therapy is a promising treatment for metastatic castration-resistant prostate cancer (mCRPC). Several beta or alpha particle-emitting radionuclide-conjugated small molecules have shown efficacy in late-stage mCRPC and one, [[177Lu]Lu]Lu-PSMA-617, is ... |
39743559 | Pivotal roles of biglycan and decorin in regulating bone mass, water retention, and bone toughness. | Proteoglycans, key components of non-collagenous proteins in the bone matrix, attract water through their negatively charged glycosaminoglycan chains. Among these proteoglycans, biglycan (Bgn) and decorin (Dcn) are major subtypes, yet their distinct roles in bone remain largely elusive. In this study, we utilized singl... |
39743555 | A self-assembling nanoplatform for pyroptosis and ferroptosis enhanced cancer photoimmunotherapy. | The microenvironment of immunosuppression and low immunogenicity of tumor cells has led to unsatisfactory therapeutic effects of the currently developed nanoplatforms. Immunogenic cell death, such as pyroptosis and ferroptosis, can efficiently boost antitumor immunity. However, the exploration of nanoplatform for dual ... |
39743532 | Facile universal strategy of presenting multifunctional short peptides for customizing desired surfaces. | Interfacial properties determine biomaterial performances, such as cell adhesion, signal exchange, and biomineralization, which affect the tissue repair cycle and efficiency of clinical applications. Peptides, as short protein sequences that have defined functionalities, are highly stable and easy to synthesize and hav... |
39714406 | Supramolecular Assembly Enhanced Linear and Nonlinear Chiroptical Properties of Chiral Manganese Halides. | Chiral hybrid organic-inorganic metal halides (HOMHs) hold great promise in broad applications ranging from ferroelectrics, spintronics to nonlinear optics, owing to their broken inversion symmetry and tunable chiroptoelectronic properties. Typically, chiral HOMHs are constructed by chiral organic cations and metal ani... |
39714372 | Polymer Films' Residual Stress Attenuation from the Supramolecular Complexation with Ultra-Small Nanoparticles for High Resolution Nanoimprint Lithography. | Nanoimprint lithography (NIL) has been broadly applied in the fabrication of nano-patterned polymer films for cost-efficiency and high through-put; however, the intrinsic tradeoff between mechanical strength and residual stress of polymer films significantly limits the NIL resolution while the harsh processing conditio... |
39688952 | Linker Installation in a Metal-Organic Framework for Enhanced Quantitative Redox Species Recognition. | Linker installation has proven to be an effective strategy for introducing diverse functional groups into metal-organic frameworks (MOFs). Reductants and oxidants are found in various environments, but their accumulation poses a danger due to their high reactivity, necessitating prompt monitoring instantly, particularl... |
39688593 | Unveiling the potential of RADA16-I peptide-coated silver nanoparticles for biomedical uses: a computational study. | Nanomaterials, specifically silver nanoparticles (AgNPs), have demonstrated great potential in biomedical applications due to their unique properties, such as antimicrobial activity and conductivity. One promising strategy to improve their biocompatibility and functional specificity is through the functionalization of ... |
39676696 | Of perfluorinated aryllead(II) complexes. | The pentafluorophenyl moiety C<sub>6</sub>F<sub>5</sub><sup>-</sup> was succesfully employed for the first time in lead(II) chemistry. We are reporting on the stable and soluble organolead(II) polymer [Pb(C<sub>6</sub>F<sub>5</sub>)<sub>2</sub>(dx)]<sub>∞</sub> (dx = dioxane). An example of a Pb(II) "ate" complex paire... |
39670845 | A water-responsive calix[4]resorcinarene system: self-assembly and fluorescence modulation. | This study explores how water content modulates the self-assembly and fluorescence behavior of two novel calix[4]resorcinarene macrocycles. These macrocycles transition from large, flattened structures in pure THF to large giant vesicles (500-5000 nm) coexisting with small micelles (3.4-3.5 nm) as the water percentage ... |
39659192 | Dissipative particle dynamics simulations on the self-assembly of rod-coil asymmetric diblock molecular brushes bearing responsive side chains. | The self-assembly behaviors of rod-coil asymmetric diblock molecular brushes (ADMBs) bearing responsive side chains in a selective solvent are investigated <i>via</i> dissipative particle dynamics simulations. By systematically varying the polymerization degree, copolymer concentration, and side chain length, several m... |
39653659 | Diastereoselective Polypseudorotaxane Formation with Planar Chiral Pillar[5]arenes via Co-crystallization Processes. | As the number of chiral ring molecules in chiral polyrotaxane increases, the number of possible stereoisomers exponentially increases. Consequently, the selective synthesis of a specific stereoisomer becomes much more challenging. To address this problem, we co-crystallized poly(ethylene glycol) and a diastereomeric ri... |
39641136 | Development of tough and stiff elastomers by leveraging hydrophilic-hydrophobic supramolecular segment interaction. | The presence of supramolecular interactions plays a crucial role in the formation of resilient multifunctional elastomers. Nevertheless, achieving elastomers with fabulous mechanical properties remains a significant challenge due to the incomplete understanding of the underlying principles. In this study, we have prese... |
39630059 | A Cu/β-cyclodextrin/reduced graphene oxide nanocomposite for efficient and multi-aflatoxin detection in rice, ginger and bean samples. | Aflatoxins (AFs) are some of the most important mycotoxins or fungal toxins that cause contamination of food products and are considered a threat to human and animal health. An efficient Cu/β-cyclodextrin/reduced graphene oxide nanocomposite (Cu/β-CD/rGO) has been prepared and applied as a new solid-phase extraction ad... |
39629671 | Catalytic strategies for detoxifying phosphorus(V) biocides. | Organophosphorus substances are employed in several industrial segments, albeit they may feature high toxicity levels depending on their structures. Based on previous extensive investigations of structure-reactivity patterns, researchers have been working on the development of catalysts as a means to detoxify phosphoru... |
39628400 | Enhanced diffusion through multivalency. | The diffusion of macromolecules, nanoparticles, viruses, and bacteria is essential for targeting hosts or cellular destinations. While these entities can bind to receptors and ligands on host surfaces, the impact of multiple binding sites-referred to as multivalency-on diffusion along strands or surfaces is poorly unde... |
39618288 | Integration of metal-organic frameworks and clay toward functional composite materials. | Metal-organic frameworks (MOFs) have become increasingly important as a class of porous crystalline materials because of their diverse applications. At the same time, significant progress has been achieved in the field of MOF-based composite materials toward novel applications based on the synergistic effect of two or ... |
39601124 | From natural to synthetic hydrogels: how much biochemical complexity is required for mechanotransduction? | The biochemical complexity of a material determines the biological response of cells triggered by a cell-material interaction. The degree in which this complexity influences basic cell-material interactions such as cell adhesion, spreading, and mechanotransduction is not entirely clear. To this end, we compared three d... |
39589070 | Nano onions based on an amphiphilic Au<sub>3</sub>(pyrazolate)<sub>3</sub> complex. | Multilayer vesicles with an onion-like architecture can form by self-assembly of organic amphiphiles such as dendrimers, small-molecule surfactants, and block copolymers. Thus far, there are limited reports about multilayer vesicles based on coordination compounds. Herein, we show that nano onions are obtained by aggre... |
39585665 | Bioinspired programmable coacervate droplets and self-assembled fibers through pH regulation of monomers. | Phase separation and phase transitions pervade the biological domain, where proteins and RNA engage in liquid-liquid phase separation (LLPS), forming liquid-like membraneless organelles. The misregulation or dysfunction of these proteins culminates in the formation of solid aggregates <i>via</i> a liquid-to-solid trans... |
39585179 | Aptamer-functionalized nucleic acid nanotechnology for biosensing, bioimaging and cancer therapy. | Nucleic acids have enabled the fabrication of self-assemblies and dynamic operations. Among different functional nucleic acids, aptamers can specifically bind to a wide range of targets, including proteins, viral antigens, living cells and even tissues, and have thus emerged as molecular recognition tools in molecular ... |
39585081 | Amyloid inspired single amino acid (phenylalanine)-based supramolecular functional assemblies: from disease to device applications. | In the evolving landscape of biomolecular supramolecular chemistry, recent studies on phenylalanine (Phe) have revealed important insights into the versatile nature of this essential aromatic amino acid. Phe can spontaneously self-assemble into fibrils with amyloid-like properties linked to the neurological disorder ph... |
39584801 | A bionic palladium metal-organic framework based on a fluorescence sensing enhancement mechanism for sensitive detection of phorate. | We have developed a biomimetic fluorescent nanoprobe (Pd-MOF) that can accurately identify phorate at a fixed wavelength for rapid, sensitive and selective detection. Pd-MOF was a nanoparticle (260.00 ± 27.83 nm) based on the linkage of Pd metal and a TCPP organic framework. It could detect phorate according to the flu... |
39584260 | Cyclic natural product oligomers: diversity and (bio)synthesis of macrocycles. | Cyclic compounds are generally preferred over linear compounds for functional studies due to their enhanced bioavailability, stability towards metabolic degradation, and selective receptor binding. This has led to a need for effective cyclization strategies for compound synthesis and hence increased interest in macrocy... |
39582426 | Development of the design and synthesis of metal-organic frameworks (MOFs) - from large scale attempts, functional oriented modifications, to artificial intelligence (AI) predictions. | Owing to the exceptional porous properties of metal-organic frameworks (MOFs), there has recently been a surge of interest, evidenced by a plethora of research into their design, synthesis, properties, and applications. This expanding research landscape has driven significant advancements in the precise regulation of M... |
39582399 | The curious case of co-planarity in di-nuclear triel complexes: a density functional investigation. | Density functional investigation of intramolecular triel (Tr) bonding present in di-nuclear aryl complexes of group 13 elements having general formula [(Tr)Me<sub>2</sub>(2,6-(X)<sub>2</sub>C<sub>6</sub>H<sub>3</sub>O)]<sub>2</sub> (Tr = B, Al, Ga, In & Tl and X = OMe, OEt, OH, OPh, NH<sub>2</sub>, SH, Cl, F) has been ... |
39582381 | An ionic-liquid functionalized metal-organic framework and its high performance as a solid electrolyte for lithium-ion conduction. | Crystalline porous metal-organic frameworks (MOFs) have attracted great interest, including in the field of solid-state electrolytes. Herein, we report a new type of solid-state electrolyte based on an MOF matrix and a Li<sup>+</sup> ionic liquid. By covalently bonding the Li<sup>+</sup> ionic liquid (MIMS·LiTFSI) on t... |
39569821 | Highly efficient CO<sub>2</sub> capture and chemical fixation of a microporous (3, 36)-connected <i>txt</i>-type Cu(II)-MOF with multifunctional sites. | Incorporating multiple functional sites in porous frameworks to enormously enhance the host-guest interactions is an effective strategy to obtain high-performance CO<sub>2</sub> capture and chemical fixation MOF materials. Herein, we designed and constructed a microporous (3, 36)-connected <i>txt</i>-type Cu(II)-based ... |
39569673 | Beyond <i>DAD</i>: proposing a one-letter code for nucleobase-mediated molecular recognition. | Nucleobase binding is a fundamental molecular recognition event central to modern biological and bioinspired supramolecular research. Underpinning this recognition is a deceptively simple hydrogen-bonding code, primarily based on the canonical nucleobases in DNA and RNA. Inspired by these biotic structures, chemists an... |
39569564 | Synthesis of β-lactam-zidovudine pronucleosides as potential selective narrow-spectrum antibacterial agents. | Since the discovery of penicillin, the forerunner of the most widely used class of antibiotics (<i>i.e.</i> β-lactams), natural compounds and their derivatives represented a major source of antibacterial therapeutic products whose availability enabled modern medical practices (invasive surgery, organ transplant, <i>etc... |
39540626 | Metal-organic framework-based hybrids with photon upconversion. | Upconversion materials (UCMs) featuring an anti-Stokes type emission establish them as an important category of photoluminescent materials. Metal-organic frameworks (MOFs) are rapidly gaining prominence as a class of versatile materials with favourable physical and chemical properties, including high porosity, controll... |
39471098 | Harnessing DNA computing and nanopore decoding for practical applications: from informatics to microRNA-targeting diagnostics. | DNA computing represents a subfield of molecular computing with the potential to become a significant area of next-generation computation due to the high programmability inherent in the sequence-dependent molecular behaviour of DNA. Recent studies in DNA computing have extended from mathematical informatics to biomedic... |
39439231 | Ultrasound mechanisms and their effect on solid synthesis and processing: a review. | Ultrasound proves to be an effective technique for intensifying a wide range of processes involving solids and, as such, is often used to improve control over both solids formation and post-treatment stages. The intensifying capabilities of ultrasonic processing are best interpreted in the context of the chemical, tran... |
39431720 | Flexible, self-healing and portable supramolecular visualization smart sensors for monitoring and quantifying structural damage. | Visually monitoring micro-crack initiation and corrosion failure evolution is crucial for early diagnosis of structural health and ensuring safe operation of infrastructures. However, existing damage detecting approaches are subject to the limited-detection of heterogeneous structures, intolerance of harsh environments... |
39374430 | Cysteinyl Leukotrienes in Allergic Inflammation. | The cysteinyl leukotrienes (CysLTs), LTC<sub>4</sub>, LTD<sub>4</sub>, and LTE<sub>4</sub>, are potent lipid mediators derived from arachidonic acid through the 5-lipoxygenase pathway. These mediators produce both inflammation and bronchoconstriction through three distinct G protein-coupled receptors (GPCRs)-CysLT<sub>... |
41810149 | Repurposing a detrimental antibody epitope as targeted therapeutics for sepsis and rheumatoid arthritis. | <h4>Background</h4>Sepsis and rheumatoid arthritis (RA) are distinct yet mechanistically related conditions commonly driven by dysregulated inflammatory responses. Here, we explored the counterintuitive hypothesis that an epitope from a deleterious anti-tetranectin (TN) antibody (mAb9) could hold unforeseen therapeutic... |
41714919 | Synthesis and Characterization of Polyacetyltetrazine from Hydrazonoyl <i>via</i> [3+3] Self-Polycycloaddition. | <h4>Background</h4>Over the past decade, tetrazines have emerged as key molecules in metal complexation, anion binding, and molecular recognition. However, limited research has focused on combining tetrazine rings into the polymer backbones.<h4>Methods</h4>This research aimed to focus on synthesizing novel 1,2,4,5-poly... |
41624471 | Network Pharmacology and Molecular Docking Approach to Identify and Investigate the Mechanisms of Active Components of Areca Catechu in Relation to Gut Disorders. | <h4>Background</h4>Gut disorders present a considerable worldwide health challenge, and increasing attention is being paid to natural substances as prospective treatment agents.<h4>Objective</h4>This research utilizes network pharmacology, molecular docking, and molecular dynamics simulations to examine the mechanisms ... |
41623534 | Alchemilla Vulgaris Compounds as Inhibitors of HPV 16 E6 Oncoprotein: Quercetin with Promising in Silico Potential. | <h4>Background</h4>The oncogenic potential of HPV remains a major global public health challenge and various natural therapeutics are being investigated to prevent cancer. The natural components of the Alchemilla vulgaris plant have various anti-inflammatory, antioxidant, antiviral, and anticancer effects.<h4>Objective... |
41586193 | Advances in cancer immunotherapy: Strategies and innovations strategies for adoptive immunotherapy of cancer. | Cancer immunotherapy has emerged as a transformative approach in oncology, offering alternatives beyond traditional treatments. This narrative review focuses on major innovations, including adoptive cell therapy (ACT), chimeric antigen receptor T-cells (CAR-T), T-cell receptor (TCR) engineering, monoclonal antibodies (... |
41517890 | Photocatalytic performance of Co-MOF-derived Co<sub>3</sub>O<sub>4</sub> nanoparticles for degradation of herbal cigarette detritus and industrial dyes in wastewater. | In the present work, Co<sub>3</sub>O<sub>4</sub> nanoparticles (Co<sub>3</sub>O<sub>4</sub> NPs) were prepared by calcination of a hydrothermally synthesized Co-MOF precursor. The X-ray diffraction (XRD) analysis results confirmed the formation of Co<sub>3</sub>O<sub>4</sub> NPs with well-defined cubic spinel oxide (Fd... |
41485981 | Enantioselective Synthesis of a Key Intermediate toward Dragmacidin E via Base-Promoted Olefin Isomerization-Ir-Catalyzed Asymmetric Hydrogenation Sequence. | We report a practical approach for synthesizing a chiral building block en route to the asymmetric total synthesis of dragmacidin E. The strategy features a base-promoted olefin isomerization of 1 followed by an Ir-catalyzed asymmetric hydrogenation under ambient hydrogen pressure. Gram-scale hydrogenation of geminally... |
41480264 | Lost paradise-anthropogenic pressure alters microbial functional diversity in an endangered endemic toad-habitat system. | Tourism-driven human activity is increasingly disrupting fragile and once-pristine ecosystems worldwide, as evidenced by coral reef degradation in the Great Barrier Reef, vegetation loss in the Himalayas, and, as demonstrated in this study, microbial shifts in isolated highland habitats such as tepui summits. Integrati... |
41480258 | Quinazoline-2,4(1H,3H)-dione derivatives as new class of CB1 Agonists: A pharmacophore-based virtual screening workflow and drug discovery. | <h4>Background</h4>The cannabinoid 1 (CB1) receptor is the primary target of Δ <sup>9</sup>-tetrahydrocannabinol (Δ <sup>9</sup>-THC), the psychoactive component of cannabis sativa (commonly known as "kif" in Morocco).<h4>Methods</h4>Here, we identified novel CB1 agonists using virtual screening approaches. First, we d... |
41477115 | In Silico and in vitro Characterization of <i>Lactobacillus acidophilus</i> Bacteriocins as ROR-1-Targeted Therapeutics in Breast Cancer. | <h4>Background</h4>The human microbiota plays a crucial role in maintaining host health and is involved in various illnesses, including cancer. The intestinal microbiota has been identified as a factor in the development of colorectal carcinoma and breast cancer (BC).<h4>Objectives</h4>This study investigated the antic... |
41473133 | HIV-1 and Artificial Intelligence: From Molecular Insight to Population Impact. | Artificial intelligence (AI) has become an indispensable ally in virology, enabling the analysis of enormous datasets that extend from viral genomes to behavioral and clinical information. HIV-1, a rapidly evolving retrovirus with extraordinary genetic diversity and a persistent latent reservoir, poses unique computati... |
41446565 | Antioxidant potential of a new macrocyclic bisbibenzyl and other compounds from <i>Combretum molle</i>: <i>in vitro</i> and docking analyses. | <h4>Introduction</h4>Free radicals are key contributors to several diseases, including cancer, inflammation, pain, and neurodegenerative disorders such as Alzheimer's disease. Due to the limitations and adverse effects of synthetic antioxidants, naturally occurring phytochemicals offer safer, more sustainable alternati... |
41410484 | Yeast as a tool for exploring disulfide-rich peptides. | Cyclic disulfide-rich peptides have become increasingly popular in drug development because their structures enhance molecular stability and allow for mutagenesis to introduce non-native functions. This review focuses on yeast-based platform technologies and their utility in advancing cyclic disulfide-rich peptides as ... |
41407375 | Site-Selective Staudinger Conjugation of Aryl Azides Driven by Intramolecular Hydrogen Bonding. | Site-selective conjugation on aryl azides is hampered by a fundamental trade-off: electron-withdrawing groups that promote the reaction often preclude further functionalization, while versatile electron-donating groups suppress reactivity. We report a strategy that resolves this by using an ortho-amido group to activat... |
41347221 | Tanshinone ⅡA Inhibits Alveolar Macrophage Polarization, Inflammation and Mitochondrial Damage by Regulating the PAPR-1 Signaling Pathway. | <h4>Background</h4>Alveolar macrophages (AMs) play a pivotal role in the initiation, resolution, and tissue repair processes of pulmonary inflammatory diseases. The regulation of poly (ADP-ribose) polymerase-1 (PARP-1) is closely associated with inflammatory mechanisms, including the expression of inflammatory mediator... |
41334807 | Integrating yeast biodiversity and machine learning for predictive metabolic engineering. | Yeast biodiversity and machine learning (ML) are transforming the landscape of metabolic engineering. While Saccharomyces cerevisiae remains foundational to industrial biotechnology due to its genetic tractability and robust growth, it struggles to synthesize complex metabolites, utilize alternative feedstocks, and wit... |
41334370 | Microfluidic organ-on-a-chip for modeling coronary artery disease: Recent applications, limitations and potential. | Coronary artery disease (CAD) encompasses a spectrum of pathologies driven by atherosclerosis, trauma, inflammation, or other etiologies that compromise coronary morphology and function, ultimately leading to myocardial ischemia and infarction. While organ-on-a-chip (OOC) technology has emerged as a transformative tool... |
41320897 | Enhancing female fertility by biomaterial-based regeneration of uterine tubes. | Tubal factor infertility remains a major cause of female reproductive dysfunction. Current therapeutic options, such as surgical repair or <i>in vitro</i> fertilization, only bypass but do not restore the dysfunctional uterine tube. Recent advances in tissue engineering and regenerative medicine (TERM) highlight biomat... |
41313306 | Fungal β-1,3-glucan synthase: a review of structure, mechanism, and regulation. | Fungal β-1,3-glucan synthase (Fks) plays a central role in synthesizing β-1,3-glucan, the main structural polysaccharide of fungal cell walls, and serves as a key target for antifungal drugs, such as echinocandins and ibrexafungerp. Recent cryo-electron microscopy (cryo-EM) studies have revealed the architecture of the... |
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