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38566387 | A Comprehensive Review on Nanoparticles as Drug Delivery System and Their Role for Management of Hypertension. | The current global epidemic of hypertension is not a disease in and of itself but rather a significant risk factor for serious cardiovascular conditions such as peripheral artery disease, heart failure, myocardial infarction, and stroke. Although many medications that work through various mechanisms of action are avail... |
38551038 | Nanomedicine: A New Frontier in Alzheimer's Disease Drug Targeting. | Alzheimer's disease (AD) is a prevalent neurodegenerative disorder affecting elderly individuals, characterized by progressive cognitive decline leading to dementia. This review examines the challenges posed by anatomical and biochemical barriers such as the blood-brain barrier (BBB), blood-cerebrospinal fluid barrier ... |
38523523 | A New Approach in the Early Electrochemical Diagnosis of Hepatitis B Virus Infection using Carbon-based Nanomaterials. | The importance of early diagnosis of hepatitis B virus infection to treat and follow up this disease has led to many advances in diagnostic techniques and materials. Conventional diagnostic tests are not very useful, especially in the early stages of infection; it is therefore suggested that nanomaterials can enhance t... |
38504573 | Mixed Solvency Concept to Replace Harmful Organic Solvent: Recent Trends and Future Challenges in Formulation Development. | Organic solvents are hazardous and should be replaced with less harmful alternatives. When developing a new formulation for a medicine with low aqueous solubility, improving its solubility might be a significant difficulty. According to the mixed solvency concept, a novel concept of solubilization, the solubility of po... |
38441021 | Targeting SIRT1 by Scopoletin to Inhibit XBB.1.5 COVID-19 Life Cycle. | Natural products have historically driven pharmaceutical discovery, but their reliance has diminished with synthetic drugs. Approximately 35% of medicines originate from natural products. Scopoletin, a natural coumarin compound found in herbs, exhibits antioxidant, hepatoprotective, antiviral, and antimicrobial propert... |
38424427 | An Enzyme-responsive Porphyrin Metal-organic Framework Nanosystem for Targeted and Enhanced Synergistic Cancer Photo-chemo Therapy. | <h4>Background</h4>The clinical efficiency of photodynamic therapy (PDT) in combination with chemotherapy has proven to be a promising strategy for tumor treatment, yet is restricted by the high glutathione (GSH) concentration at the tumor site and nonspecific drug targeting.<h4>Objective</h4>The goal of the current re... |
38415437 | Clinical Outcomes and Effectiveness of CRLX101 for Solid Tumors: A Systematic Review and Meta-analysis. | <h4>Background</h4>While it has been demonstrated that delivery of cytotoxic chemotherapy using nanoparticles greatly improves patient drug tolerance and reduces toxicity when compared to the standard formulation, the crucial question of whether they also increase anticancer efficacy remains. The CRLX101 is a nanoparti... |
38411887 | Principles of Hanging Drop Method (Spheroid Formation) in Cell Culture. | A type of three-dimensional (3D) cell culture models which is simple and easy is hanging drop method. The hanging drop method emerges as a pivotal technique with diverse applications in cancer research and cell biology. This method facilitates the formation of multicellular spheroids, providing a unique environment for... |
38379403 | Protective Role of Electroacupuncture Against Cognitive Impairment in Neurological Diseases. | Many neurological diseases can lead to cognitive impairment in patients, which includes dementia and mild cognitive impairment and thus create a heavy burden both to their families and public health. Due to the limited effectiveness of medications in treating cognitive impairment, it is imperative to develop alternativ... |
38375849 | Advanced Targeted Drug Delivery of Bioactive Nanomaterials in the Management of Cancer. | Cancer is defined as the unchecked expansion of aberrant cells. Radiation, chemotherapy, and surgery are currently used in combination to treat cancer. Traditional drug delivery techniques kill healthy proliferating cells when used over prolonged periods of time in cancer chemotherapy. Due to the fact that the majority... |
38284722 | Effect of Chitosan Coating on Drug Carrier Capacity of Metal-organic Framework MIL-100(Fe) Contained Cyclophosphamide. | <h4>Introduction</h4>Among the various investigated drug carriers, metal-organic frameworks (MOFs) have recently gained attention due to their ability to adsorb different drugs and compatibility with various surface modification strategies. In this study, molecular dynamic simulation was conducted to assess the effect ... |
38243940 | Controlled Release of Aspirin in the Body using Pectin-coated ZIF-8 Nanoparticles. | <h4>Introduction</h4>Zeolitic imidazolate frameworks (ZIFs) play a crucial role among metalorganic frameworks due to their highly desirable properties, including high surface area, appropriate pore size, and excellent thermal and chemical stability.<h4>Method</h4>In this study, ZIF-8 loaded with aspirin and coated usin... |
38243924 | DFT Study of Interaction between Teriflunomide and β-cyclodextrin. | <h4>Introduction</h4>This study employs Density Functional Theory (DFT) to investigate the interactions between Teriflunomide and β-cyclodextrin in the gas phase.<h4>Methods</h4>The non-bonded interaction effects of the Teriflunomide compound with β-cyclodextrin on the chemical shift tensors, electronic properties, and... |
38092036 | Fracture prediction in rheumatoid arthritis: validation of FRAX with bone mineral density for incident major osteoporotic fractures. | <h4>Objectives</h4>FRAX uses clinical risk factors, with or without BMD, to calculate 10-year fracture risk. RA is a risk factor for osteoporotic fracture and a FRAX input variable. FRAX predates the current era of RA treatment. We examined how well FRAX predicts fracture in contemporary RA patients.<h4>Methods</h4>Adm... |
37937554 | Applications of Nanomedicine in Brain Tumor Therapy: Nanocarrierbased Drug Delivery Platforms, Challenges, and Perspectives. | <h4>Background</h4>The most difficult kind of cancer to treat is brain cancer, which causes around 3% of all cancer-related deaths. The targeted delivery is improved with the use of technologies based on nanotechnology that are both safe and efficient. Because of this, there is now a lot of research being done on brain... |
37916495 | Multifunctional Drug Delivery System: Nanosponges. | In recent years, nanotechnology has been the focus of study for the cure of different diseases, among which nanosponge delivery system is one of a kind. Nano sponges are tiny, highly porous, three-dimensional nanostructures with a size range of 250 nm<sup>-1</sup> μm in an amorphous or crystalline structure. Nanosponge... |
37904560 | Dendrimers: Patents for Alzheimer's Disease. | Cells and nervous system connections that are crucial for movement, coordination, strength, sensation, and thought are gradually damaged in neurodegenerative illnesses. Amyloid beta (Aβ)- accumulating macromolecules in the brain are the primary cause of the disease's chronic symptoms, according to analysis carried out ... |
37849227 | Nano-approaches and Recent Advancements in Strategies to Combat Challenges Associated with Thyroid Cancer Therapies. | The prevalence of thyroid cancer (TC) is more common in women and is up to 43% in patients aged between 45-65 years. The battle against TC is hampered by the lack of effective diagnostic and therapeutic approaches. The effectiveness of surgical procedures, such as thyroidectomy and nutraceutical treatments, are accompa... |
37519201 | Untangling Breast Cancer: Trailing Towards Nanoformulations-based Drug Development. | All over the world, cancer death and prevalence are increasing. Breast cancer (BC) is the major cause of cancer mortality (15%) which makes it the most common cancer in women. BC is defined as the furious progression and quick division of breast cells. Novel nanotechnology-based approaches helped in improving survival ... |
37496133 | Advances in Enzyme-responsive Supramolecular <i>In situ</i> Self-assembled Peptide for Drug Delivery. | Because of low immunogenicity, ease of modification, and inherent biosafety, peptides have been well recognized as vehicles to deliver therapeutic agents to targeted regions with improved pharmacokinetic characteristics. Enzyme-responsive self-assembled peptides (ERSAPs) show superiority over their naive forms due to t... |
41906364 | A Next-Generation ELISA for the Detection of Anti-(Para)Nodal Antibodies in Autoimmune Nodopathy and COVID-19 Vaccinated Individuals. | <h4>Background and aims</h4>Autoimmune nodopathy (AN) is a subtype of antibody-mediated inflammatory neuropathy targeting the node of Ranvier (NoR). Diagnosis requires detection of anti-(para)nodal autoantibodies like contactin-1 and neurofascin-155 via ELISA or cell-based assays, but protocols are inconsistent. Causes... |
42033019 | Induced Circular Dichroism From the Binding of Achiral Bivalent Ligands to Transthyretin. | Achiral bivalent ligands capable of simultaneous occupation of both hormone binding sites of transthyretin generate a substantial and complex induced near ultraviolet circular dichroism spectrum during protein binding, revealing the dynamics of this process. Reduced temperature and pH slow the interaction and reveal tw... |
42026971 | Synergistic Photophysical and Mechanical Enhancement in Europium Supramolecular Hydrogel by Incorporating Gd(DPA)<sub>3</sub> Complex (DPA = Dipicolinate). | Lanthanide hydrogels HGLn with iminodiacetic acid (Ln = Eu and Gd) and Na<sub>3</sub>[Ln(DPA)<sub>3</sub>]·9H<sub>2</sub>O complexes (DPA = dipicolininate) were successfully synthesized via hydrothermal microwave-assisted and via precipitation, respectively. Incorporation of Ln(DPA)<sub>3</sub> complexes into the HGLn ... |
42025584 | Design of Multi-Epitope DIVA-Compatible Vaccine Candidate Against Canine Parvovirus 2. | Canine parvovirus type 2 (CPV-2) is a highly contagious and often fatal canine pathogen, with antigenic variants (CPV-2a, 2b, 2c), maternally derived antibody (MDA) interference, and lack of Differentiating Infected from Vaccinated Animals (DIVA) capability limiting current vaccines. Using an immunoinformatics-based re... |
42024771 | A Density Functional Theory-Based Investigation of a pH- and Redox-Driven Tristable [2]Rotaxane in CH<sub>2</sub>Cl<sub>2</sub> Dilute Solution. | A recently synthesized pH- and redox-driven tristable [2]rotaxane in dichloromethane solution (Angew. Chem. 2025, 64, e202414609) has been investigated within the framework of the Density Functional Theory DFT) in a polarizable and dielectric media via self-consistent reaction field method. Optimized molecular species ... |
42012913 | Ferrocene-Based Sensors for Green Analytical Applications in Environmental, Biomedical, Industrial, and Food Monitoring. | Ferrocene derivatives represent a transformative class of molecular sensors, combining exceptional electrochemical stability with tunable redox characteristics that enable precise detection across diverse analytical challenges in environmental, medical, and industrial applications. This comprehensive review examines th... |
42011645 | Recent Advances in Wounded Lettuce Discoloration: A Review of Pre- and Postharvest Influencing Factors, Pathways, and Prevention Strategies. | Lettuce is highly valued for its nutritional composition and health-promoting properties. However, undesirable discoloration (i.e., pinking and browning) of wounded lettuce tissues is considered a major factor leading to economic losses in the lettuce industry. Previous reviews have primarily discussed the influencing ... |
42010854 | Insights Into Bifenthrin Stereoisomers and Their Regulatory Implications. | Bifenthrin (BF) is a synthetic pyrethroid insecticide extensively applied in agricultural and urban pest control. The molecular structure contains two stereogenic centers, giving rise to four stereoisomers with distinct physicochemical, electronic, and biological properties. However, many regulatory frameworks still co... |
42010847 | Azobenzene-Functionalized Ionic Liquids: Light-Responsive Surfactants With Catalytic Potential. | We report on the synthesis of surface-active azobenzene-based surface-active ionic liquids (AzoSAILs) with tunable and photoswitchable physicochemical properties. The reversible isomerization between the trans- and the cis-form was studied in different solvents and concentration by spectroscopic methods. The potential ... |
42010843 | Self-Assembly Behavior of Monodisperse PEG Amphiphiles Bearing Hydrophobic Units with Distinct Molecular Shapes in Water. | The shape of hydrophobic units on the self-assembly of amphiphiles in pure water remains underexplored. In this work, three types of octaethylene glycol (OEG)-appended amphiphiles bearing propeller-shaped, twisted, and planar hydrophobic units were synthesized. They formed different types of assemblies, such as liquid ... |
42010818 | Structural basis of secreted acid phosphatase polymerization in the Leishmania parasite. | Enzymes that assemble into filaments typically transition between protomeric and polymeric states in response to cellular conditions. In contrast, the secreted acid phosphatase (SAP) of Leishmania, one of the most abundant extracellular glycoproteins produced by the parasite and regarded as a major virulence factor in ... |
42003664 | Recent Advances in the Synthesis and Processing of Carbon Nanotubes and Carbon Nanocomposites for Energy Storage, Biomedical, and Environmental Applications. | Carbon nanotubes (CNTs) and carbonnanocomposites (CNCs) representsome of the most innovative materials in nanotechnology, finding applications in biomedical devices, aerospace, and environmental remediation. Recent developments have improved the synthesis of CNTs, including variants that are single walled (SWCNTs) and ... |
42003503 | Adsorption and Sensing Behavior of Pristine, P-Doped, and Al-Doped Boron Nitride Nanosheets Toward Toxic Hydrogen Fluoride Gas: Insights from Density Functional Theory Analysis. | This study employs first-principles density functional theory (DFT) to investigate the adsorption behavior of pristine, P-doped, and Al-doped boron nitride nanosheets toward toxic hydrogen fluoride (HF) gas. Molecular dynamics simulations conclusively validate the structural integrity of doped nanosheets. The adsorptio... |
42003221 | Artificial Intelligence Clustering Approach for Force Mapping Analysis of Polyacrylic Acid (PAA)/Polyethylene Oxide (PEO) Polymer Brushes for Biosensor Applications. | Biocompatibility of a biosensor can be achieved by grafting polymer brushes onto a solid surface. These brushes must be able to attract specific analytes or repel unwanted entities. This is obtained with weak polyelectrolyte polymer brushes that shrink or swell depending on external stimuli. In this study, the conforma... |
42002396 | RPA Combined With CRISPR/Cas12a for Rapid and Ultrasensitive Detection Dual-Gene of Methicillin-Resistant Staphylococcus aureus (MRSA). | The increasing issue of infections caused by methicillin-resistant Staphylococcus aureus (MRSA) necessitates rapid and reliable diagnostic methods. While existing RPA-CRISPR/Cas12a platforms have demonstrated potential for MRSA detection, most rely on single-gene targets or require multiple Cas enzymes. Here, we have d... |
42002299 | Engineering Chirality in the Solid State: Co-Crystallization as a Strategy for Chiral Induction and Resolution. | Chirality plays a fundamental role in chemistry, biology, and materials science, where molecular activity and performance often depend on enantiomeric purity. However, most synthetic methods produce racemic mixtures, making efficient strategies for enantioseparation and chiral amplification essential. Among the availab... |
41983503 | Protective Effect of Intracellular Compounds of Lactobacillus plantarum on Goat Sperm Quality During Cryopreservation. | <h4>Background</h4>Cryopreservation of sperm is a key strategy for preserving and transmitting the genetic traits of valuable or endangered breeds and is particularly applied in goats to improve sperm quality and performance.<h4>Objectives</h4>This study was conducted to evaluate the effect of supplementing cryopreserv... |
41980543 | Meniscus-Mediated Imaging of Soft Biological Membranes Using 200 kN/m Ultra-Stiff 15 MHz MEMS AFM Probes. | Coronaviruses, among other membrane-enveloped viruses, can remain infectious on surfaces in ambient air for days. Many bacteria and fungi also expose their plasma membranes to air environments. Key survival strategies in air include hydrophobic coatings to prevent water loss and waxy or silica-based resistant cell wall... |
41979185 | Synthesis, crystal structure and antifungal activity of an ethylenediammonium-templated nickel(II) pyromellitate coordination polymer. | Coordination polymers represent an important class of inorganic-organic hybrid materials constructed from metal nodes interconnected by multidentate organic ligands. Here, a one-dimensional anionic coordination polymer, namely, catena-poly[ethylenediammonium [tetraaquanickel(II)]-μ-benzene-1,2,4,5-tetracarboxylato] dih... |
41974629 | Cyclic Peptide Conformational Landscapes Through the Lens of Mass Spectrometry and Orthogonal Spectroscopy. | Cyclic peptides occupy a structurally dynamic region of chemical space, where function often arises from ensembles rather than a single dominant fold. Closed backbones, frequent N-methylation, heteroatoms, unnatural amino acids, and a strong propensity for metal coordination create dense conformational and coordination... |
41969219 | An ALS-associated mutation in the C-terminal α-helix of TDP-43 uncouples condensate formation and amyloid assembly. | TAR DNA-binding protein 43 (TDP-43) plays a critical role in RNA metabolism and is incorporated into biomolecular condensates called stress granules. In amyotrophic lateral sclerosis (ALS) and several other neurodegenerative disorders, TDP-43 undergoes aberrant phase transitions, forming insoluble amyloid aggregates, i... |
41958406 | High-throughput automated molecular replacement for small-molecule MicroED data. | Interest in electron diffraction (ED) for structural characterization of both proteins and small molecules has grown significantly over the last decade. While ab initio phasing methods remain the gold standard for ED data from small-molecule samples, radiation beam damage during data collection and poor crystallinity o... |
41954472 | The master molecule that built biology: How water shaped the chemistry of life. | The deep entanglement of biomolecular structure and function with aqueous systems supports the view that water actively sculpted both molecules and processes during the origins of life and continues to constrain evolution today. Nature's rules of biochemistry and biophysics have survived for nearly 4 billion years. The... |
41940632 | Phosphate- and pH-dependent self-assembly of recombinant spider silk proteins. | The process of molecular self-assembly is an omnipresent mechanism in nature to generate a variety of efficient and functional hierarchical architectures, and inspires tailored material design and development. Thereby, self-assembly is based on a controlled interplay and association of monomers into highly ordered stru... |
41927019 | Effect of Home-Based Exercise and Influence of Training Principles on Cardiorespiratory Fitness in Sedentary Healthy People and Patients With Cardiovascular Disease: A Systematic Review With Meta-Analysis. | The effectiveness of home-based exercise programmes may vary depending on compliance to exercise training principles. Therefore, the aim of this review was to investigate the effect of unsupervised home-based exercise programmes on cardiorespiratory fitness (CRF) in healthy sedentary individuals and patients with cardi... |
41916768 | RETRACTION: Binding Affinity and In Vitro Cytotoxicity of Harmaline Targeting Different Motifs of Nucleic Acids: An Ultimate Drug Designing Approach. | Retraction: P. Bhattacharjee, T. Ghosh, S. Sarkar, P. Pandya, and K. Bhadra, "Binding Affinity and In Vitro Cytotoxicity of Harmaline Targeting Different Motifs of Nucleic Acids: An Ultimate Drug Designing Approach," Journal of Molecular Recognition 31, no. 4 (2018): e2687. https://doi.org/10.1002/jmr.2687. The above a... |
41914022 | The Reactive Extrusion Cationization of Starches as a Novel Physicochemical Surface Modification Method. | The modification of starches by cationization is a fundamental physicochemical process aimed at improving their physicochemical properties and expanding their industrial applications. Traditionally, this modification is associated with long duration, high energy consumption, and waste generation. This article proposes ... |
41863067 | Comprehensive Characterization of Solution-Cast Polycaprolactone/MXene/Gelatin Composite Films for Biomedical Applications. | Despite significant advances in the development of biocompatible platforms, such as scaffolds, films, and hydrogels, a challenge remains in formulating films with the right balance of mechanical properties and bioactivity. Herein, we developed biocompatible composite films based on polycaprolactone (PCL), MXene, and ge... |
41841242 | Evolving Analytical Methods for the Quantification of Methocarbamol: A Critical Review. | Methocarbamol (MT), a centrally acting muscle relaxant, presents significant analytical challenges due to its low ultraviolet (UV) absorptivity, rapid metabolism, and pronounced pH-dependent instability. The presence of guaifenesin-related impurities and interference from co-formulated analgesics further complicate its... |
41833406 | Angiotensin 1-7 Modulates the Dynamics and Activation of the Proto-Oncogene Mas Receptor. | The proto-oncogene Mas receptor (MasR) is a class-A (orphan-type) G protein-coupled receptor (GPCR) that mediates the cardioprotective effects of Angiotensin 1-7 (Ang 1-7) within the renin-angiotensin system (RAS). Despite its therapeutic relevance, the molecular mechanisms underlying MasR activation remain elusive due... |
41813167 | miR-146a/b-5p-IRAK1-NF-κB Axis Regulates Unexplained Recurrent Spontaneous Abortion. | Unexplained recurrent spontaneous abortion (URSA) remains a prevalent obstetric issue, the underlying causes of which are still not fully understood. MicroRNAs (miRNAs) have the potential to influence URSA through their regulation of gene expression. This study aimed to screen key miRNAs and to verify their regulatory ... |
42035450 | Active Site Engineering of Mn-Doped CeO<sub>2</sub> Nanozymes: Enhanced Reactivity and Specificity for Colorimetric Detection of Perfluorooctanoic Acid in Waters. | The on-site monitoring of perfluorooctanoic acid (PFOA) in aquatic ecosystems is critical for safeguarding environmental and public health. However, conventional colorimetric sensing platforms are often constrained by a fundamental trade-off between signal sensitivity and target selectivity. To overcome this limitation... |
42035172 | Waste-to-sensor upcycling of polyethylene terephthalate over Ag/Zr-MOF photocatalyst for microplastic degradation and AI-assisted heavy metal detection. | This study aims to develop an integrated waste to sensor platform that couples photocatalytic PET depolymerization with on stream quantification of coexisting heavy metals. We achieve this by preparing AIM-202 through surface coordination of Ag to a water stable Zr-aspartate MOF (MIP-202), creating Ag<sup>0</sup>/Ag<su... |
42035137 | An enhanced sonodynamic antibacterial strategy using bismuth porphyrin metal-organic frameworks to inhibit bacterial endogenous antioxidant H<sub>2</sub>S metabolism. | Surgical site infections (SSIs) represent a global healthcare burden, a challenge intensified by the increasing prevalence of antibiotic resistance. To address drug-resistant bacterial infections, various non-antibiotic therapeutic strategies have been explored, among which sonodynamic therapy (SDT) has emerged as a pr... |
42035070 | Porphyrin oriented bimetallic sonodynamic MOF for enhanced ferroptosis and cGAS-STING pathway mediated antitumor immunotherapy. | Sonodynamic therapy (SDT) offers deep tissue penetration and noninvasive tumor treatment, yet its efficacy remains limited by inadequate reactive oxygen species (ROS) generation and an immunosuppressive tumor microenvironment (TME). In this work, we developed a porphyrin-based bimetallic nanoplatform by integrating Fe ... |
42034630 | Click/release reaction and SO<sub>2</sub> recycling for multichannel dynamic chiroptical materials. | Constructing dynamic chiral materials via a combined covalent and non-covalent strategy remains an emerging and challenging task. Here, we report a unique example of this strategy using a specialized click-and-release reaction to create a multichannel dynamic chiroptical system. We utilize a highly efficient inverse el... |
42034609 | Spontaneous efficient degradation of polyesters in soil by an enzyme@MOF platform. | Waste plastics represent a serious and growing environmental problem. Whereas biodegradable polyesters such as polycaprolactone (PCL) and polylactic acid (PLA) offer a potential solution, their spontaneous degradation takes up to 3 years in the field. Industrial composting, an alternative approach, is labor and energy ... |
42034612 | Revising the tectonic chronology of East-West Antarctica since the breakup of East Gondwana. | East-West Antarctic separation from ~43-11 Ma is well-documented through marine magnetic anomalies in the western Ross Sea, yet multiple lines of evidence suggest earlier extension, including Victoria Land uplift (~55-50 Ma) and reconstruction gaps between the Lord Howe Rise and Campbell Plateau. Here, we present marin... |
42033495 | Inhibition of SARS-CoV-2 spike S1-ACE2 binding interaction and downregulation of ACE2 gene expression by Malaysian stingless bee honey and its bioactive compound, stilbamidine (SDC). | <h4>Background</h4>The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus infects host cells by binding to angiotensin-converting enzyme 2 (ACE2). Stilbamidine (SDC), a compound identified in Malaysian Kelulut honey (KH), has been reported to exhibit favourable binding affinity towards ACE2. This study ... |
42033367 | Self-Assembly of Binary Nanocrystals Grafted with End-Functionalized Polymers: A Molecular Dynamics Simulation Study. | Self-assembly of polymer-grafted nanocrystals (PGNCs) has become an area of increasing interest, as the polymer ligands can have rich conformations and be functionalized with diverse end groups and the interplay of conformational entropy and distinctive interaction enthalpy facilitates the programmable self-assembly of... |
42033369 | Two Low-Dimensional MOFs: Promising Sensors for Selective and Sensitive Detection of Nitroaromatic Compounds in Aqueous and Vapor Phases. | Nitroaromatic compounds (NACs) are widely used in industrial production and daily life, posing significant hazards to both the ecological environment and human health. However, the development of efficient and user-friendly sensors still faces substantial challenges. In this study, we successfully designed and construc... |
42034063 | Pharmacologic glycoengineering of Fcγ receptor IIIa enhances force-resistant IgG-FcγR interactions and anti-tumor antibody efficacy. | Therapeutic monoclonal antibodies (mAbs) are central to cancer treatment but often show incomplete efficacy. We show that transient pharmacologic inhibition of complex N-glycans in host cells ("glycoengineering") enhances the in vivo activity of multiple depleting mAbs, including mAbs already engineered for heightened ... |
42032854 | Bombyx mori BmLis1 inhibits BmNPV replication by promoting the cell cycle G2/M progression. | Lissencephaly-1 (Lis1) is a highly conserved cytoplasmic dynein regulator found in eukaryotes. It is involved in regulating processes such as cell proliferation, spindle orientation, nuclear migration, and microtubule-dependent transport. Baculovirus frequently hijacks these cellular processes to facilitate infection a... |
42032409 | Possible Ways of Reducing Adverse Events Associated with mRNA Vaccines Encapsulated in Lipid Nanoparticles. | mRNA vaccines have a number of advantages over traditional vaccines: high safety (no risk of infection, minimal possibility of integration into the genome), the ability to induce both cellular and humoral immune responses, as well as the possibility of repeated administration due to the absence of antiviral immunity. T... |
42032317 | A Cu(I)-catalysed click reaction generates ROS-triggered cleavable linkages in aqueous media. | Click reactions that form functional linkages are rare. Among the few catalytic options, none directly delivers a cleavable connector. Here we introduce copper(I)-catalysed allene-ketone addition (CuAKA), an operationally simple reaction that is mutually orthogonal to CuAAC (copper(I)-catalysed azide-alkyne cycloadditi... |
42032064 | Calcium-molybdenum-cobalt-2-methylimidazole trimetallic organic framework as a saturable absorber for passive mode-locked thulium-holmium doped fiber lasers. | Ultrafast fiber lasers operating in the 2 μm spectral region require robust and highly nonlinear saturable absorbers (SAs) to achieve stable mode-locking. This study demonstrates that a calcium-molybdenum-cobalt-2-methylimidazole (CaMoCo-MIM), a trimetallic organic framework (TMOF), functions as an efficient SA, enabli... |
42031764 | Solvent-switch-driven covalent organic framework nanosheets for ultra-robust and recyclable gas separation membrane. | Covalent organic frameworks (COFs) exhibit significant potential for gas separation applications, primarily due to their remarkable stability and precisely adjustable pore structures. However, creating sustainable COF-based gas separation membranes remains unachieved and is confronted with significant challenges, inclu... |
42031367 | Architecture-Encoded Degradation Kinetics and Pathways through the Shape and Size of Polymeric Vesicles. | Programming the degradation of supramolecular nanostructures is central to their function, clearance, and adaptability, yet prevailing approaches rely primarily on a complex chemical design. How intrinsic physical parameters dictate their degradability remains largely unexplored, limiting general design strategies. Her... |
42030974 | Metal-organic framework-derived sulfide-based bifunctional electrocatalyst for efficient water electrolysis in alkali solutions. | Metal-organic frameworks (MOFs) exhibit ultra-high specific surface areas and tunable porous structures. Thus, they can function as highly efficient electrocatalysts for water-splitting applications. However, the practical application of pristine MOFs is limited by insufficient active sites, sluggish charge transfer ki... |
42030526 | Effect of Diethyl Phosphonate Substituents on the Supramolecular Organization and Optical Response of Porphyrin Langmuir-Blodgett and Langmuir-Schaefer Films. | A great amount of attention is currently being paid to the development of low-dimensional nanoarchitectonics, such as functional films, that exhibit highly sensitive and selective optical responses to analytes. Porphyrins are particularly attractive for this field due to their outstanding optical and coordination prope... |
42030488 | Driving Force of Colloidal Nanoparticle Self-Assembly. | By defining the driving force for colloidal nanoparticle self-assembly as the negative gradient of the Helmholtz free energy difference with respect to generalized coordinates, F=-∂(ΔA)/∂ξ, this work establishes a universal thermodynamic framework for diverse assembly pathways. Using advanced multiscale molecular simul... |
42030445 | Kirkendall-Effect-Driven Synthesis of Cu/Ru Nanocages for Electrocatalytic Nitrate Reduction via Tandem Catalysis. | The high-yield synthesis of uniform Cu/Ru nanostructures is crucial for catalyzing nitrate (NO<sub>3</sub><sup>-</sup>) reduction to ammonia (NH<sub>3</sub>), yet it remains highly challenging. Herein, we report a facile strategy for synthesizing Cu/Ru bimetallic nanocages in high yield, driven by the Kirkendall effect... |
42030444 | Hydrogen-Bond Gating of Interfacial Capacitance in Amine-Rich Hybrid Interfaces for Redox-Free Ionic Recognition. | Continuous, selective ion detection in aqueous media without redox mediation remains an outstanding challenge in electrochemical sensing. Here, we introduce a hydrogen-bond-gated, nonfaradaic charge-transduction mechanism that enables real-time selective halide detection (F<sup>-</sup> ion) under ambient conditions. Th... |
42030404 | Crown Ether-Incorporated Metal Halides Unify High-Performance Iodine Capture with Built-In Optical Monitoring of Adsorption Process. | The management of radioactive iodine, a typical fission product released in the nuclear fuel cycle and nuclear accidents, demands not only a deep decontamination capability but also reliable monitoring of adsorbent status. However, this critical need is yet unrealized by conventional sorbents. To bridge this gap, we pr... |
42030402 | Confinement of Organic-Inorganic Hybrid Perovskites within MOF Cavities for Synergistic Regulation of Third-Order Nonlinear Optics. | Exploring the regulatory effect of organic-inorganic hybrid perovskites on the third-order nonlinear optical (NLO) properties of MOFs is of great significance. In this work, we used Co-MOF {[Co<sub>1.25</sub>(HL)<sub>0.5</sub>(Pz-NH<sub>2</sub>)<sub>0.25</sub>(<i>μ</i><sub>3</sub>-O)<sub>0.25</sub>(<i>μ</i><sub>2</sub>... |
42030225 | Construction of Cerium-Based Metal-Organic Frameworks for Photocatalytic Oxidation of Tetrahydroquinoline. | Green photocatalytic oxidation materials have attracted extensive research interest as an eco-friendly strategy for sustainable development in environmental and chemical engineering. In this work, a novel two-dimensional cerium-based metal-organic framework (<b>Ce-MnTCPP</b>) was solvothermally synthesized under mild c... |
42030088 | Ionic Assembly of Molecular Clusters toward Hierarchically Ordered Granular Materials with Tunable Viscoelasticity. | Molecular granular materials (MGMs) assembled from subnanometer clusters exhibit unique viscoelasticity but are often limited by complex covalent synthesis. Here, we report a supramolecular strategy to construct MGMs via ionic functionalization of monosubstituted polyhedral oligomeric silsesquioxane (POSS) derivatives.... |
42030074 | Similar Prenucleation Clusters in Hot-Injection and Heating-Up Approaches to CdS Colloidal Semiconductor Quantum Dots. | Colloidal semiconductor quantum dots (QDs) have been synthesized extensively via hot-injection approaches. Using cadmium sulfide (CdS) as a model system, we present compelling evidence for the first time that similar prenucleation clusters (PNCs) appear in both hot-injection and heating-up approaches to CdS QDs. Two re... |
42030004 | Chirality-Dependent Supramolecular Biomaterials Remodeling of Scar Microenvironment via Integrin-Mediated Regulation for Hypertrophic Scars Therapy. | Hypertrophic scars, characterized by excessive fibroblast activation, present significant clinical challenges. Current treatments (e.g., laser, surgery, steroids) face limitations: Surgery is costly and associated with high recurrence rates, while pharmacological interventions often induce pain and exhibit low bioavail... |
42029953 | Intervention of hIAPP amyloid aggregation by smart post-transmuting anti-amyloidogenic peptidomimetics. | hIAPP (human islet amyloid polypeptide) aggregates have been implicated in the development of type 2 diabetes mellitus (T2DM). As a prelude to developing a potential cure for T2DM, researchers worldwide have employed various strategic molecular entities to target β-sheet-rich hIAPP aggregates, known as disruptors, or t... |
42029910 | Photo-modulation of proton/water transmembrane transport through bis(imidazole-amide)-tetrafluoro-azobenzene switch. | Water and proton transport across biological membranes is essential for cellular function. The development of stimuli-responsive artificial transport systems to replace malfunctioning protein channels is crucial for potential therapeutic applications. Here, we report a photoswitchable azobenzene-based channel that enve... |
42029634 | Synthetic receptors for steroids: from molecular recognition to biomedical functions. | Aqueous-phase molecular recognition plays a central role in many biological systems, motivating the development of artificial receptors capable of operating in water. Steroidal compounds, defined by a rigid tetracyclic framework and encompassing biologically important molecules such as cholesterol, steroid hormones, an... |
42029631 | Molecular engineering of high-performance TADF emitters <i>via</i> Buchwald-Hartwig amination for OLED applications. | Thermally activated delayed fluorescence (TADF) emitters, capable of harvesting both singlet and triplet excitons for 100% internal quantum efficiency, represent a cornerstone of third-generation OLED technology. The development of these materials critically depends on robust and versatile synthetic methodologies. This... |
42029281 | Hydration-driven structural reorganization and switchable thermal-photoinduced spin-state dynamics in iron(II) spin-crossover crystalline solids. | We present a comprehensive structural and spectroscopic investigation of the Fe(II) spin-crossover (SCO) crystalline solid, [Fe(3-bpp)<sub>2</sub>]<sub>2</sub>[Cr(ox)<sub>3</sub>](ClO<sub>4</sub>)·5H<sub>2</sub>O, highlighting the pivotal role of hydration in governing spin-state switching dynamics. Single-crystal XRD ... |
42029229 | Thermally Induced Supramolecular Polymorphism Strategy Enables Fabrication of Emissive Tunable Gold Nanoclusters Assemblies. | Developing controllable multicolor emissive materials is highly desirable in the field of optical devices. However, the efficient strategies to achieve this from a single gold nanoclusters (AuNCs) are still scarce. Herein, we harness a thermally induced supramolecular polymorphism strategy to get distinct nanostructure... |
42029127 | Iridium-based metallo-organic triangles as efficient photosensitizers for rhodamine B photocatalytic oxidation degradation. | In this study, two metallo-organic triangular architectures (S1 and S2) based on iridium(III) complexes were successfully constructed. Electron paramagnetic resonance (EPR) analysis confirmed that S1 and S2 can efficiently generate reactive oxygen species (ROS) under light irradiation. In photocatalytic degradation exp... |
42029068 | MOF-based arginine nanocarriers for coordinated immunometabolic and antitumor modulation in triple negative breast cancer. | L-Arginine (L-Arg) is a key immunometabolite and nitric oxide (˙NO) precursor with therapeutic potential in cancer and immunotherapy. However, its clinical application is hindered by poor bioavailability and uncontrolled dosing. Here, two distinct metal-organic frameworks (MOFs), NH<sub>2</sub>-MIL-125(Ti) and MOF-808(... |
42029071 | Kinetically controlled self-assembly of atom-precise gold nanoclusters into multicolor emissive supramolecular assemblies. | Establishing self-assembly chemistry based on metal nanoclusters (NCs) holds great potential for promoting performance improvement and enriching functional diversity. Herein, by a well-designed liquid reaction strategy, the individual atomic-precise Au<sub>5</sub> NCs self-assembled into a highly regular and ordered na... |
42029035 | Fabrication of Hierarchically Porous Metal-Organic Framework Films by an In Situ Impregnation Conversion Method. | A novel in situ impregnation conversion method was proposed for constructing hierarchical porous metal-orgainc framework (MOF) films. This approach relies on the conversion of a Cu(OH)<sub>2</sub>@PVA precursor film into a Cu-MOF film via a controlled in situ growth process. The resulting MOF films exhibited high acces... |
42029041 | Synergistic non-covalent-recognition-enabled highly efficient through-space charge transfer for specific synthetic cannabinoid EG-2201 detection. | Specific-recognition-enabled trace-level precise detection of analytes with intrinsic low chemical reactivity is of great significance, yet its realization is challenging as such analytes cannot be effectively identified <i>via</i> active covalent reactions. Here, a naphthalimide-based fluorescent-probe-enabled sensing... |
42029038 | Enhancing immune protection in dairy cattle: role of <i>Escherichia coli</i> Nissle 1917 in boosting the efficacy of a <i>Mycoplasma bovis</i>-BoAHV-1 combined vaccine. | Bovine respiratory disease (BRD) ranks among the most prevalent and economically burdensome diseases affecting the global dairy cattle industry, primarily resulting from co-infection with multiple pathogens, including <i>Mycoplasma bovis</i> (<i>M. bovis</i>) and bovine alphaherpesvirus type 1 (BoAHV-1). Despite the av... |
42028903 | Isomeric Nonpolar Amino Acid-Derived Metal-Organic Frameworks for Xenon/Krypton Separation. | Efficient xenon/krypton separation remains challenging due to their similar physicochemical properties. Herein, we demonstrate that ligand isomerism can be leveraged as an effective structural handle for constructing new metal-organic frameworks from readily available, low-cost amino acids. Using leucine and isoleucine... |
42028697 | An engineered membrane separation system using a binder-free immobilized heterojunction photocatalyst for enhanced energy-efficient organic dye separation. | MOF-based photocatalytic membranes provide a promising solution for efficient, selective, and continuous pollutant removal by effectively integrating membrane separation and photocatalytic degradation. However, a combination of factors, including single-MOF photocatalysis, high driving pressure, and binder-based immobi... |
42028691 | Construction of Two Electroactive (3,24)-Connected <i>rht</i> Metal-Organic Frameworks: Anion-Dependent Charge/Electron and Energy Transfer. | By incorporating electroactive triphenylamine units into a hexacarboxylate linker, two zinc-based metal-organic frameworks with 3,24-connected <i>rht</i> net were constructed, demonstrating unique anion-dependent intermolecular charge/electron and energy transfer. The crystals of <b>Zn-MOF-1</b> incorporating nitrate a... |
42028675 | Density-Energy Balanced Selection of Chiral Honeycomb Superstructures from Deprotonated Carboxylate Molecules on Ag(111). | Here, we investigate the self-assembly of 4,4',4″-(1,3,3a1,4,6,7,9-heptaazaphenalene-2,5,8-triyl) tribenzoic acid on Ag(111) by scanning tunneling microscopy. Upon annealing, complete deprotonation drives the formation of a family of periodic honeycomb superstructures, denoted as <i>HC</i><sub><i>N</i></sub> (<i>N</i> ... |
42028671 | Ultrasensitive and Highly Selective Detection of Calcium Ions Using KD<sub>5</sub>-Modified Asymmetric Nanochannels. | Artificial solid-state nanochannels have attracted significant interest as promising nanofluidic tools for ion/molecule detection, DNA sequencing, and biomimetic applications. In this work, we designed an aspartic acid-rich peptide, KD<sub>5</sub> (Lys-Asp<sub>5</sub>, KDDDDD), via a green tag-assisted approach. Levera... |
42028642 | Injectable Hydrogel with Rapid Coagulation, Low Swelling, and High Burst Pressure Tolerance Properties for Long-Term Management of Bleeding Wound. | Injectable wet-adhesive hydrogels represent a promising approach for managing traumatic hemorrhage, yet their clinical translation is often hindered by excessive swelling and inadequate sealing stability. Herein, we report an injectable hydrogel (denoted as PACmC) with rapid coagulation, ultrahigh burst pressure tolera... |
42028639 | Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma. | Real-time monitoring of kidney-infiltrating cytotoxic T lymphocytes (CTLs) is crucial for evaluating immunotherapy in renal cell carcinoma (RCC). However, existing imaging probes often exhibit "always-on" signals and poor renal clearance, limiting their ability to detect renal immune responses. Herein, we report renal-... |
42028600 | Harnessing Supramolecular J-Aggregates in Deep Eutectic Solvents for Tunable NIR Photothermal and Photodynamic Therapy. | J-aggregates of cyanine dyes have emerged as powerful photothermal and imaging agents in the near-infrared (NIR) window due to their red-shifted absorption, narrow bandwidth, and strong excitonic coupling. However, their instability in biological environments often necessitates external carriers or stabilizers that com... |
42028596 | A Host-Guest Switched Fluorescent Detection Method for Oxytetracycline via Quenching of N,Mg-CDs and Target-Induced Emission. | The issue of antibiotic pollution in the environment continues to attract attention. Herein, a host-guest switched ratiometric fluorescent detection method for oxytetracycline (OTC) was developed by quenching the fluorescence of nitrogen- and magnesium-codoped carbon dots (N,Mg-CDs) and inducing fluorescence enhancemen... |
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