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42027143 | Elemental Barcoding Beyond Optics: Metal-Isotopic Suspension Array for Emerging High-Throughput Diagnostics. | ConspectusPrecision medicine is transforming healthcare by enabling stratified and personalized treatments driven by our growing ability to comprehensively characterize molecular features in diseased tissues and liquid biopsies. Advances in genomic, transcriptomic, proteomic, and metabolomic profiling have increasingly... |
42027045 | A bioinspired metal-organic helicate drives electrocatalytic ethane production from carbon dioxide. | We designed the metal-organic cage electrocatalyst H1, which activates the <i>in situ</i>-formed adduct between CO<sub>2</sub> and piperazine <i>via</i> host-guest encapsulation, thereby significantly lowering the CO<sub>2</sub> reduction potential and achieving the lowest potential for CO<sub>2</sub> to ethane convers... |
42034137 | Dextran-driven hyperbranched black gold nanoparticles templated by guanosine quartets as broadband absorbers for photothermal therapy. | We report a straightforward aqueous synthesis of black gold nanoassemblies based on supramolecular guanosine quartet (G4) assembly and a dextran co-matrix, in which the functional photothermal component is an interconnected Au(0) plasmonic network. Dextran acts as a multifunctional polymeric co-matrix that helps organi... |
42026969 | Integrative, Orientational Self-Sorting at the Four-Crossing Level in Molecular Knots and Links. | Low-symmetry mechanically interlocked molecules (MIMs) remain challenging targets because of their anisotropic structures and synthetic complexity. We devised a self-sorting strategy employing two unsymmetric flexible bidentate ligands, L<sup>ab</sup> and L<sup>cd</sup>, which co-assemble with two size-differentiated r... |
42026966 | Two-Dimensional Metal-Organic Framework (TM<sub>3</sub>X<sub>12</sub>C<sub>24</sub>) as Promising Cathodes for Li-O<sub>2</sub> Batteries. | Two-dimensional (2D) metal-organic frameworks (MOFs) have emerged as promising electrocatalysts for Li-O<sub>2</sub> batteries due to their tunable structures, high specific surface areas, and well-defined active sites. Herein, first-principles calculations combined with the computational hydrogen electrode model are s... |
42026850 | Topology-Driven Conformational Constraint Enables High-Temperature Organic Phosphorescence. | Achieving organic phosphorescence that remains stable at elevated temperatures is challenging because thermally activated molecular motions typically accelerate non-radiative decay of triplet excitons. Here, we report a topology-driven conformational constraint strategy to enable high-temperature organic phosphorescenc... |
42026171 | Two-dimensional metal-organic frameworks offer all-in-one cocatalysts for photocatalytic overall water splitting. | Photocatalytic overall water splitting holds great promise for sustainable hydrogen production. For overall water splitting performed by one-step excitation, both the hydrogen evolution and oxygen evolution reactions are hindered kinetically; hence, it is necessary to employ site-selective modification of photocatalyst... |
42026172 | Breaking the methanol/dimethyl carbonate azeotrope using a metal-organic framework with tetrahedral potassium-ion cluster gates. | With the growing demand for high-purity dimethyl carbonate (DMC) in the battery industry, the separation of methanol (MeOH) and DMC azeotrope to achieve battery-grade purity (>99.99%) has become a pivotal bottleneck in the production of DMC. Here we design and synthesize an ionic metal-organic framework with tetrahedra... |
42024819 | Post-Synthetic Modification of Cd-MOF with Dual Emission as a Ratiometric Probe for Visual Detection. | In contemporary society, heavy metal ions have posed significant threats to water systems and human health, for which timely and accurate detection is of much significance. In this work, a new metal-organic framework, CUST-1022, [Cd(H<sub>2</sub>BPDC)(phen)]CH<sub>3</sub>OH was synthesized via the solvothermal method. ... |
42024268 | Revised Swedish FRAX models and the establishment of age-dependent intervention thresholds. | We developed a revised FRAX® model for Sweden, derived from recent incidence data on fractures, mortality, and origin of birth, and defined age-dependent intervention thresholds.<h4>Purpose</h4>Since the development of the Swedish FRAX model in 2008, fracture incidence patterns have changed. The primary aim of this stu... |
42024269 | Forearm BMD predicts fracture independently of FRAX. | The relationship between bone mineral density (BMD) at the forearm and fracture risk was determined in a meta-analysis of primary data from 11 cohort studies of 35,121 men and women. Low forearm BMD was a significant predictor of fracture risk, independently of FRAX®.<h4>Introduction</h4>The aim of this study was to qu... |
42024194 | Development trends and translational opportunities in self-assembled herbal bioactive materials research. | <h4>Background</h4>Self-assembled herbal bioactive materials (SAHBMs) represent a rapidly advancing frontier integrating phytochemistry, supramolecular chemistry, and biomedical engineering. By leveraging the intrinsic pharmacological activity and self-organization of herbal compounds, SAHBMs offer improved solubility,... |
42024149 | Interfacial Hydrogen Bond-Mediated Rigidification Strategy Coupled with Stepwise Antenna Effect for Ultrasensitive Electrochemiluminescence Detection. | Lanthanide metal organic frameworks (Ln-MOFs) are promising electrochemiluminescence (ECL) emitters due to their unique lanthanide antenna effect. However, the vibrational modes of organic ligands significantly induce nonradiative transitions and the inherent poor conductivity of MOFs limits charge injection, which hin... |
42024146 | Highly Dispersed Pt-Decorated Oxygen-Vacancy-Rich MOF-Derived SnO<sub>2</sub> Nanostructures on MEMS Hot Plate for ppb-Level Hydrogen Detection. | With the rapid development of the hydrogen energy economy, there is an increasingly urgent demand for low-power-consumption and integrable sensors capable of accurate and real-time monitoring of hydrogen (H<sub>2</sub>). In this study, SnO<sub>2</sub> nanoparticles rich in oxygen vacancies were successfully prepared vi... |
42023896 | Anion(I<sup>-</sup>)-π(bisphosphonium)<sup>2+</sup> photoluminescence enhanced by [Pt(CN)<sub>2</sub>(Me-phpy)]<sup/>. | A major challenge in luminescent materials is inefficient energy utilization, where a substantial fraction of absorbed energy is dissipated through non-radiative pathways. This limitation can be addressed at the molecular level by rational design of emissive systems. Combining suitable chromophores and/or supporting fr... |
42023859 | Fine-Tuning the SMM Properties of a Bis(ZnDy)-Based Compound by Rationally Reducing/Increasing the Electron Density in the Equatorial Plane Perpendicular to the O<sub>phenoxido</sub>-Dy-O<sub>phenoxido-bridges</sub> Direction. | Five new bis(ZnDy) complexes with the general formula [Zn<sub>2</sub>(μ-H<sub>2</sub>L)<sub>2</sub>(μ-dicarb)Dy<sub>2</sub>(L')<sub>2</sub>(L'')<sub>2</sub>]X<sub>2</sub>·solv were synthesized using Mannich bis(compartmental) ligand H<sub>4</sub>L (highly phenoxido-containing macrocycle). Tetrafluorosuccinate (<b>1</b>... |
42023711 | Positional Isomerism Influencing Differential Supramolecular Metallogelation: In Situ AgNP Formation and Heavy Metal Ion Detection. | Three adipic dihydrazide-based receptors functionalized with a pyridine moiety were synthesized by varying the positions of "pyridine -N", while one more receptor was fabricated as a control compound appended with phenyl moieties in the two arms instead of pyridine. The positional isomeric effects on the metallogelatio... |
42021575 | Cysteine-rich peptide for chiral self-assembly: a multi-functional antioxidant with novel SH-mediated ROS-responsive disassembly from natural medicine. | Peptide self-assembly is a promising strategy for developing bioactive nanomaterials with improved drug delivery and therapeutic performance. However, artificial design approaches may not fully incorporate natural paradigms and typically avoid cysteine-rich sequences due to their inherent instability. Challenging this ... |
42020375 | Macrophage metabolic reprogramming by vanadium released from glucose-responsive bio-gel accelerates diabetic wound repair. | Dysregulated glucose metabolism in diabetic wound macrophages impairs polarization toward the reparative M2 phenotype, leading to compromised innate immunity, chronic inflammation, and delayed wound healing. However, effective strategies to restore macrophage metabolic function remain limited. Here, inspired by vanadiu... |
41943857 | Construction of hollow fiber stirring bar based on dummy molecularly imprinted polymers for the selective determination of organophosphorus pesticides in food samples. | In this study, the sol-gel method and layer-by-layer self-assembly technique were used to graft dummy template molecularly imprinted polymers (DMIPs) onto CG161M microspheres, yielding the DMIPs@CG161M composite, which was then applied as an adsorbent for detecting organophosphorus pesticides in food. A structurally an... |
42031247 | A food-grade ionic network microcapsule for marine collagen-derived peptide‑zinc chelate stabilization and digestive delivery. | Marine by-products are a valuable source of bioactive peptides with significant nutritional and functional potential. However, metal-chelate complexes derived from such peptides exhibit poor stability during processing and gastrointestinal digestion. In this study, a food-grade, ionically self-assembled microcapsule wa... |
42031025 | Co-amorphization of felodipine with puerarin: Enhanced dissolution, photostability and oral bioavailability. | The antihypertensive drug felodipine (FEL) suffers from poor solubility, leading to low bioavailability, and is also known to undergo photodegradation. Co-amorphous formulations represent a promising strategy for simultaneously enhancing the physicochemical properties and stability of drugs. This study aimed to develop... |
42028203 | MOF-derived ternary ZnCo-Ni LDHs for high-energy-density supercapacitors: synergistic effects and enhanced ion transfer. | The development of electrode materials that simultaneously possess high energy density and excellent cycling stability remains a critical challenge hindering the widespread application of supercapacitors. Consequently, traditional binary layered double hydroxides (LDHs) suffer from nanosheet stacking and limited active... |
42026867 | Molecular dynamics simulations reveal internal tension in native state collagen fibrils. | Collagen fibrils are the building block of many biological tissues, which viability depend on the fibrils properties. Altered properties of collagen fibrils are central to the appearance of many diseases, while physiological or native properties must be reproduced for tissue engineering. Yet, the self-assembly, the str... |
42025061 | Multifunctional roles of ascorbic acid in biopolymer food packaging: From performance tuning to shelf life extension: A review. | Petroleum-based plastic packaging poses risks to food safety and the environment, driving the shift to biodegradable biopolymers-yet their poor mechanical/barrier properties limit application. Ascorbic acid (AA), a natural, safe, and low-cost additive, emerges as a multifunctional solution for biopolymer-based food pac... |
42021537 | Ursolic Acid-Loaded Iron-MOF Nanomedicine Inhibits Lung Cancer Metastasis via JAK2/STAT3 Suppression and Ferroptosis. | Lung cancer metastasis is the primary cause of patient mortality, underscoring an urgent need for highly effective and low-toxicity therapies. Ursolic acid (UA), a natural triterpenoid, possesses potent antitumor activity, yet its clinical translation has been hindered by poor water solubility, low bioavailability, and... |
42021348 | Multilevel synergistic mechanisms of a nanocarrier-enabled topramezone herbicide against invasive weeds. | The rapid proliferation of invasive weeds has emerged as an escalating "major threat", and the inefficient utilization and environmental dispersion of conventional herbicides pose persistent challenges in agricultural production. Herein, an amphiphilic hydrophilic-lipophilic diblock polymer (HLDP) was constructed to de... |
42021125 | Boosting Alkaline Oxygen Evolution Kinetics by Tailoring the Noncovalent Interaction on CoOOH. | Understanding the effect of noncovalent interactions of intermediates at the polarized catalyst-electrolyte interface is key to improving the kinetics of electrocatalytic reactions. Herein, we employ cobalt oxyhydroxide (CoOOH) as a model catalyst, select carboxylate-based additives to strategically modulate the interf... |
42020816 | Parathyroid hormone and alkaline phosphatase are associated with fracture risk in non-dialysis-dependent chronic kidney disease. | We studied over 45,000 Danish adults with non-dialysis-dependent chronic kidney disease to assess whether parathyroid hormone (PTH) and alkaline phosphatase (ALP) were associated with fracture risk. Elevated PTH (over twice normal) and ALP (above 70 U/L) were linked to higher fracture rates, suggesting these markers ma... |
42020713 | Bimetallic Fe/K γ-cyclodextrin metal-organic frameworks with enhanced loading capacity and tunable release behavior. | Cyclodextrin-based metal-organic frameworks (CD-MOFs) are bio-derived porous coordination materials that combine hierarchical porosity with intrinsic host-guest recognition. Here, we report the synthesis of a bimetallic γ-cyclodextrin metal-organic framework incorporating potassium and iron ions (Fe/K-CD-MOF) via a con... |
42019943 | Electroreductive Radical Olefin Difunctionalization with Fluorinated Gases Enabled by Dosage Delivery from a Metal-Organic Framework. | Fluoroalkyl groups are crucial for tuning the pharmacokinetic properties of drug-like molecules, motivating the development of practical methods for their late-stage installation. Despite extensive progress, most contemporary fluoroalkylation strategies rely on impractical reagents or harsh reaction conditions, limitin... |
42018780 | Simultaneous Desalination and COD Degradation Enabled by the ZnMoS<sub>3</sub>@ZIF-8/BVO Heterojunction Photoanode. | Converting wastewater or saltwater into clean, safe, and fresh water offers a solution to the pressing global issues of water scarcity and pollution. In this work, a novel ZnMoS<sub>3</sub>@ZIF-8/BVO composite was fabricated by successfully anchoring ZnMoS<sub>3</sub> nanoparticles onto a metal-organic framework (MOF) ... |
42018763 | Martensitic Transition Associated with Spin-Crossover Enabling Crystal Jumping and Pyroelectric Response. | Integrating electronic switching with molecular machinery remains a central challenge in the development of multifunctional stimuli-responsive materials. Herein, we demonstrate a synergistic coupling of spin crossover (SCO) and molecular motion within a hydrogen-bonded supramolecular architecture constructed from spin-... |
42018731 | Generalizing Pore-Space Partitioning in Metal-Organic Frameworks. | The development of a theoretical framework typically proceeds from idealized cases toward increasingly nonideal situations. Over the past decade, pore-space partitioning (PSP) has been predominantly explored in high-symmetry systems based on trimers at the highest <i>D</i><sub>3h</sub> symmetry. Extending PSP toward a ... |
42018730 | Turn-On Metal Ion Responsive Behavior Enabled by Coordination-Driven Multicomponent Self-Assembly. | The advancement of industrialization, fossil fuel reliance, and agricultural expansion has intensified environmental contamination by heavy metal ions, and they demand urgent attention. In this work, we proposed a multicomponent-assembly-based strategy for the construction of a turn-on fluorescence sensing system and d... |
42018727 | Self-Assembly of Urea-Connected Pyrene-Glutamate Conjugate: Linker and Fluoride Ions Modulated Circularly Polarized Luminescence. | Here, we report the synergistic modulation of circularly polarized luminescence (CPL) achieved through the integration of a flexible linker and a fluoride-responsive urea unit. Two pyrene-conjugated chiral building blocks, <b>PUG</b> and its flexible-linked analogue <b>PMUG</b>, were designed and synthesized, incorpora... |
42018710 | Recognition-Based Chiral Amplification through Adaptive Locking. | Chiral amplification in host-guest systems remains difficult to control because structures tend to be either too rigid to accommodate a guest or too flexible to maintain stable helicity. This is a limitation where binding of chiral substrates is a key to chiroptical induction and the production of, e.g., a circular dic... |
42018663 | Cyclodextrin-Epichlorohydrin-Cyanoguanidine Polymer for Resveratrol Delivery to Enhance Human Chondrocyte Function in Cartilage Repair. | Water-soluble β-cyclodextrin-epichlorohydrin polymers (CDPs) are widely used in drug delivery and regenerative medicine. Herein, we report a novel β-cyclodextrin-epichlorohydrin-cyanoguanidine polymer (CDPC) for resveratrol (RES) delivery in cartilage repair. Cyanoguanidine (CyG), a nitrogen-rich compound remaining non... |
42018534 | Systematic investigation of double emulsion dewetting dynamics for the robust production of giant unilamellar vesicles. | Giant unilamellar vesicles (GUVs) embody biomimetic membranes with compartmentalization and serve as simplified models to better understand complex biochemical and biophysical processes. Recently, double emulsion droplet microfluidics has proven to be a promising platform for their production, offering greater throughp... |
42018510 | Synthesis, surface activities, aggregation properties and oil washing performances of novel cardanol-based surfactants. | A mixed cardanol sulfonate surfactant (MYBS) of disubstituted styrene unsaturated cardanol sulfonate (2,4-YBS) and monosubstituted styrene unsaturated cardanol sulfonate (2-YBS) was synthesized by optimizing the optimal synthesis conditions of the three-step reaction of alkylation, sulfonation and neutralization. The m... |
42018247 | A deep dive into ferritin nanoparticle advancements: experimental and computational perspectives. | Ferritin, a natural iron-storage protein, has emerged as a versatile platform in nanotechnology and biomedicine due to its biocompatible 12 nm nanocage, intrinsic targeting via the transferrin receptor 1, and adaptability for diverse applications. This review integrates recent experimental and computational advances in... |
42017999 | Comparative investigation of uridine and Hachimoji RNA base interaction with single-walled carbon nanotube. | <h4>Context</h4>Single-walled carbon nanotubes (SWCNTs) are promising platforms for biosensing because their electronic properties are sensitive to molecular adsorption. While canonical nucleic acid bases have been extensively studied, little is known about how synthetic Hachimoji bases interact with nanotube surfaces.... |
42017954 | Construction of Dimension-Dependent Naphthalenediimide-Based MOF Materials with Free Hydroxyl Active Sites: Stimulation Responses of Ionochromism, Electrochromism, and Visual Artificial Film Labeled on Cations. | Smart metal-organic framework (MOF) chromic materials that respond to chemical or electrical stimuli are highly desirable for daily life and optoelectronic applications. Three novel MOFs: [Mn(H<sub>2</sub>NDISA)(DMF)<sub>2</sub>] (<b>1</b>), [Zn(H<sub>2</sub>NDISA)(DMF)<sub>2</sub>] (<b>2</b>), and [Cd(H<sub>2</sub>NDI... |
42017972 | From statistical mixtures to structural insights: characterisation of heterometallic [M<sub>4</sub>L<sub>6</sub>]<sup>8+</sup> coordination cages using high resolution ion mobility mass spectrometry. | Using high-resolution ion mobility-mass spectrometry (IM-MS), we demonstrate the resolution and characterisation of heterobimetallic [M<sub>4</sub>L<sub>6</sub>]<sup>8+</sup> coordination cages, enabling the identification and interrogation of individual mixed metal assemblies from complex mixtures. IM-MS guided synthe... |
42017939 | Dynamic Regulation of Supramolecular Chirality in an Amphiphilic Dimeric Macrocycle Through Azobenzene-Based Photoisomerization. | The dynamic control of supramolecular chirality continues to represent a significant challenge in the development of adaptive functional materials. Inspired by dynamic planar chirality modulation and the host-guest chemistry of pillararenes, we report a stimuli-responsive supramolecular system capable of reversible chi... |
42017935 | Distorted Nanographenes by Embedding a Cyclopenta[<i>a</i>]heptalene Core and Multiple Additional Heptagons: Chiral Supramolecular π-Dodecamer and Co-crystal with Fullerenes. | Nanographenes containing fused pentagon-heptagon units (e.g., 5-7, 5-7-5, or 7-5-7 ring motifs) have demonstrated remarkable electronic and photophysical properties, whereas carbon π-skeletons embedding well-defined 5-7-7 ring units remain elusive. Herein, we present two novel nanographenes incorporating a cyclopenta[<... |
42017934 | Tailoring the Plasmonic Response of Gold Nanobipyramids via Enzymatic Etching for a Highly Sensitive and Multicolor Competitive Immunoassay for the Detection of Aflatoxin B<sub>1</sub>. | Rapid on-site monitoring of aflatoxin B<sub>1</sub> (AFB<sub>1</sub>) is critical for food and medicine safety. Herein, a multicolor plasmonic immunoassay was developed for AFB<sub>1</sub> detection by combining competitive enzyme-linked immunosorbent assays (ELISA) with enzyme-mediated etching of gold nanobipyramids (... |
42017933 | Subzero Conductivity in Antifreeze-Free Ionic Gels from Liquid Crystalline Cellulose-Protein Networks. | The development of sustainable, bioderived, conductive ionic gels for low-temperature applications remains a critical challenge, particularly in eliminating reliance on ethylene glycol-based antifreezing agents. This study introduces a cellulose-based ionic gel system that leverages a hierarchical network of multiscale... |
42017910 | Photoresponsive HOF-Based Intelligent Packaging for Real-Time Monitoring Food Freshness. | Real-time monitoring of food freshness is critical for public health, yet conventional packaging lacks the capability for quality feedback. While biogenic amines (BAs) are well-established indicators of food freshness assessment, most of reported sensors rely on the single "turn-off" mode that are prone to environmenta... |
42017906 | A Pt@MOF-derived branch-leaf nanoarray: a mechanically flexible and high-performance biosensor for non-enzymatic electrochemical glucose detection. | Developing mechanically flexible nanoarray electrodes with strong catalytic performance is necessary for non-enzymatic glucose biosensing. Herein, we present a self-supported Pt@MOF-derived branch-leaf nanoarray that functions as an efficient electrode for non-enzymatic electrochemical glucose sensing. The as-prepared ... |
42017825 | Hydrogen-bond enhanced Tb/Eu-MOF for visual detection of multiple trace fluoroquinolones in seawater and a portable 3D-printed sensor. | To address the urgent need for rapid and on-site detection of trace antibiotic contamination in marine environments, this study employs a hydrogen-bond network enhancement strategy to construct a highly salt-resistant dual-lanthanide MOF, Tb/Eu-BTC@BTEC, for the sensitive and visual sensing of three fluoroquinolone ant... |
42017770 | Magnetic Metal-Organic Framework (MOF)-Mediated Precision Capture of Mitochondria Reveals Subcellular Metabolic and Lipid Remodeling of Crabtree Effect in Yeast. | Crabtree effect, defined as the propensity of yeast to prioritize fermentation over respiration in high-glucose environments, is a classic metabolic adaptation. However, the limitations of conventional mitochondrial isolation methods have hindered in-depth investigation of the effect's suborganellar impact. To directly... |
42017693 | Electrode-Orthogonal Non-Covalent Self-Assembly Programs Microenvironments around Molecular Electrocatalysts. | Here, we introduce a catalyst design strategy where non-covalent self-assembly enables molecular control over the active site and microenvironment at the same time to drive efficient electrosynthesis in water. Using anthraquinone-catalyzed H<sub>2</sub>O<sub>2</sub> electrosynthesis from O<sub>2</sub> under neutral con... |
42017387 | QBP1 Peptide as a Potential Anti-Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study. | Self-assembly and aggregation of human islet amyloid polypeptide (hIAPP, or amylin) into β-sheet-rich oligomers and fibrils have been implicated in pancreatic β-cell dysfunction and failure, contributing to the pathogenesis of type 2 diabetes (T2D). Substantial effort has gone into developing inhibitors, particularly s... |
42017333 | A chiral heterometallic Ag<sub>4</sub>Cu<sub>4</sub> nanocluster: environment-sensitive phosphorescence and efficient electrocatalytic nitrate reduction to ammonia. | We report an atomically precise chiral Ag<sub>4</sub>Cu<sub>4</sub> nanocluster featuring a helically symmetric bitetrahedral core and a rigidified ligand shell enforced by intramolecular π-π stacking. Single-crystal structural analysis reveals that the π-π interaction acts as a supramolecular lock, suppressing non-rad... |
42017296 | Amphiphilic poly(aminoester) dendrimers: click reaction-enabled synthesis, structure-governed self-assembly and degradation. | Poly(aminoester) (PAE) dendrimers are attractive materials for biomedical applications owing to their biodegradability and precise structure, effective synthesis and favourable safety profile. We report here a click chemistry-enabled divergent-convergent strategy for the efficient synthesis of amphiphilic PAE dendrimer... |
42017272 | Covalent organic framework membranes for ion separation and ion-driven energy conversion. | Covalent organic framework (COF) membranes have moved from crystalline porous solids to processable platforms for ion separation and ion-transport-based energy conversion. Their ordered nanochannels and chemically addressable pore walls enable precise control over effective pore size and topology, channel alignment, an... |
42015920 | Biofilm- and Spore-Disruptive Star-Shaped Poly(l-lysine)/Hyaluronic Acid Microgels for Targeted Oral Therapy of <i>Clostridioides difficile</i> Infection. | <i>Clostridioides difficile</i> infection (CDI) remains a major healthcare challenge due to recurrent disease, spore persistence, and biofilm-associated tolerance, while conventional antibiotics often disrupt gut microbiota. Here, we report a star-shaped poly(l-lysine) dendrimer (G3-PLL<sub>9</sub>) formulated into hya... |
42015921 | Crown Ether-Based Co-Self-Assembled Monolayer Enhances the Interaction with Perovskite for High-Performance Solar Cells. | The interface engineering of perovskite solar cells (PSCs), especially the optimization of the buried interface, is crucial for enhancing device efficiency and stability. To overcome the limitations of conventional self-assembled hole transport monolayers (SAMs), such as insufficient film density, inadequate defect pas... |
42015907 | A Low-Symmetry Fe<sup>II</sup> Tetrahedron From a Flexible Tritopic Ligand. | Most high yielding low symmetry cages formed by metal-ligand coordination are assembled through strictly defined ligand and/or metal ion geometries which have been manipulated to form systems with complex architectures. In this work, we report the near-quantitative synthesis of a new S<sub>4</sub>-symmetry meso achiral... |
42015903 | Intercalation-enabled reversible disorder and efficient iodine capture in a two-dimensional metal-organic framework. | We demonstrate intercalation-induced reversible order-disorder transitions in a two-dimensional metal-organic framework. Enabled by exceptionally weak interlayer interactions, iodine reversibly inserts into the interlayer region under mild conditions, triggering pronounced interlayer expansion and lattice disorder with... |
42015877 | Amplified Assembly of a Multifunctional 3D DNA Nanomachine for Electrochemical and Colorimetric Dual-Mode Assays. | DNA nanomachines have been widely applied in biosensing; however, further enhancing their signal amplification capability and assay reliability remains a major challenge. Herein, a novel strategy was proposed to construct a multifunctional three-dimensional DNA nanomachine for the development of an electrochemical and ... |
42015871 | A Renal-Clearable Tantalum Contrast Agent Enables Precise CT Diagnosis and Subtyping of Acute Kidney Injury. | Precise diagnosis and subtyping of acute kidney injury (AKI) are crucial for clinical decision-making and prognosis. However, current in vivo imaging techniques lack the necessary precision, sensitivity, and resolution to meet this demand. Here, we report a renal-clearable, tantalum-rich carbon dot (Ta-rCD) contrast ag... |
42015859 | From metal nodes to sulfur capture: design principles and challenges in MOF-based adsorptive desulfurization. | The persistent presence of thiophenic sulfur compounds in fuels is a major challenge for achieving ultra-deep desulfurization because conventional methods struggle to remove stable aromatic molecules like DBT, BT, and 4,6-DMDBT. Their strong molecular rigidity, low reactivity, and steric hindrance limit the effectivene... |
42015816 | A High-Metal-Content 2D Conjugated Metal-Organic Framework With a Bis-Salphen Architecture for Dendrite-Free Sodium Metal Anodes. | Two-dimensional conjugated metal-organic frameworks (2D c-MOFs) are promising candidates for electrochemical applications. However, their performance is frequently constrained by conventional designs that utilize large planar conjugated ligands. Such architectures not only complicate synthetic routes but also inherentl... |
41948876 | Keratinocytes biocompatibility, antibacterial and antioxidant properties of porous coacervate phosphate glass fibres and powders loaded with cerium and clove oil: a comparative study. | Porous biomaterials offer significant advantages in tissue engineering by promoting cellular attachment and enhancing flow of fluids. Here we present a versatile, sustainable and low-cost manufacturing technology to produce porous phosphate-based glass fibres (PGFs) and powders (PGPs) in the system P<sub>2</sub>O<sub>5... |
41943639 | Sulfur-centered non-covalent interactions: emerging themes and challenges from rotational spectroscopy. | Non-covalent interactions involving sulfur are linked to a myriad of chemical and biological processes, playing a crucial role in biochemistry, supramolecular chemistry and crystal engineering. However, precise determination of the energetic and structural properties of these weak, less directional and dispersion-contr... |
41925626 | Late-stage chirality generation strategies for the total synthesis of macrocyclic natural products. | Macrocyclic natural products, including macrolactones, macrolactams, macrocyclic (depsi)peptides, and macrocyclic cyclophanes, occupy a chemical space that does not overlap significantly with that of traditional low molecular weight and sp<sup>2</sup>-carbon rich pharmaceuticals. Traditionally, total synthesis toward m... |
41919645 | SmartCIF: a context-aware multi-agent system for automated preprocessing and curation of MOF CIFs. | Computational screening of metal-organic frameworks (MOFs) relies on crystallographic inputs that are commonly treated as "computation-ready". In practice, however, conventional CIF preprocessing often applies fixed-parameter treatments, overlooking the structural details described in the original reports. To address t... |
41914847 | A theoretical verification of the Lewis acid-catalyzed transformation of diazo compounds <i>via</i> a borane carbene species. | As versatile carbene precursors, diazo compounds have been widely used for carbene transfer reactions in organic synthesis. Different from the well-studied transition-metal catalyzed activation of diazo compounds, the activation modes of the Lewis acid-catalyzed activation of diazo compounds are still unknown. Herein, ... |
41914430 | Hen egg lysozyme fibrils act as amyloid nucleating agents for β-lactoglobulin and insulin. | Understanding the mechanism of amyloid cross-seeding has become fundamentally important for unraveling the molecular basis of amyloid-associated diseases. Hence, the intrinsic crosstalk potential between different amyloidogenic proteins has become an important area of investigation that explores how the amyloid fibrils... |
41906726 | Interplay of molecule-substrate and intermolecular interactions in [5]thiaheterohelicene assembly on Ag(111). | The adsorption and self-assembly of racemic [5]thiaheterohelicene (<i>rac</i>-[5]TH) adsorbed on Ag(111) were investigated using molecular dynamics (MD) simulations and density functional theory (DFT) calculations and compared with scanning tunneling microscopy (STM) results. While the molecule is physisorbed on Ag(111... |
41883302 | Proline-mediated conformational rigidity governs the ice-binding behavior of antifreeze glycopeptides. | Antifreeze glycoproteins (AFGPs) are among the most potent inhibitors of ice recrystallization, yet the conformational basis of their activity and the effects of proline mutations in short AFGP peptides remain unclear. Here, molecular dynamics simulations were used to examine the interfacial conformations and ice-growt... |
41738093 | Unveiling the role of water in the coupling of pyrroles and isocyanates to amidopyrroles inside a hexameric resorcinarene capsule. | DFT calculations uncovered the crucial role of non-structural water molecules trapped inside the cavity of a self-assembled hexameric resorcinarene capsule in the reaction between <i>N</i>-methylpyrrole and phenyl isocyanate to generate an amidopyrrole through two crucial steps: C-C coupling and a 1,3C → N proton wire ... |
42035509 | Porous organic polymers driven by bis-urea anion receptor sites for adsorption of perfluoroalkyl carboxylic acids. | Perfluoroalkyl carboxylic acids (PFCAs), a representative class of per- and polyfluoroalkyl substances (PFASs), have drawn increasing attention due to their extreme persistence and potential health risks. Conventional adsorbents for adsorption of PFCAs mainly rely on hydrophobic and electrostatic interactions. Herein, ... |
42034580 | Integrated microfluidic sensor array based on mixed-valence cerium metal organic framework for machine learning-assisted identification of antioxidant biomarkers. | Accurate identification of antioxidants is crucial for health assessment and food safety, yet conventional analytical methods often suffer from limited portability and operational efficiency. Herein, we propose an integrated microfluidic colorimetric sensor array based on a mixed-valence cerium metal-organic framework ... |
42034581 | Engineering Mo vacancies in hybrid zeolitic imidazolate frameworks to downshift the d-band center and promote CO desorption for efficient CO<sub>2</sub> electroreduction. | The electrocatalytic carbon dioxide reduction reaction (CO<sub>2</sub>RR) is a highly promising strategy toward carbon neutrality. However, for its practical implementation, it is imperative to develop novel electrocatalysts that are structurally simple, cost-effective, and capable of delivering high current densities.... |
42034390 | Glue it together: self-assembly of the antibacterial GTPase GBP1. | Guanylate-binding proteins (GBPs) are interferon-inducible large GTPases that play a central role in cell-autonomous immunity against intracellular bacterial pathogens. A defining feature of GBPs is their ability to translate GTP binding and hydrolysis into large-scale conformational rearrangements that drive self-asse... |
42034094 | Static/dynamic pressure -regulated formation of inclusion and non-inclusion complexes between Lotus seed starch and Chlorogenic acid: Pressure-induced evolution of intermolecular forces in complexes. | This study compared the effects of static pressure (SP, 100/500 MPa) and dynamic pressure (DP, 10/50 MPa) treatments on the formation and properties of lotus seed starch-chlorogenic acid (LS-CA) non-inclusion (SP-NC-100, DP-NC-10) and inclusion (SP-IC-500, DP-IC-50) complex systems. SP broke the long chains of amylose,... |
42026442 | Ultrasound-assisted supramolecular solvent extraction with enzymatic pretreatment of Celastrus orbiculatus roots: Process optimization, enrichment, and antibacterial activity. | Ultrasound offers a greener and more efficient alternative to conventional extraction methods, requiring less solvent and shorter processing times. This study developed an ultrasound - assisted enzyme - supramolecular solvents (SUPRAS) extraction (UAESE) method to synergistically extract two key triterpenoids from Cela... |
42025912 | Physics-inspired explainable AI for mechanistic and decision support in drug discovery. | Explainable artificial intelligence (XAI) is increasingly recognized as essential for trustworthy drug discovery, yet many approaches remain post hoc and correlational. This review examines physics-inspired XAI as a framework for improving mechanistic interpretability and decision support at the molecular design stage.... |
42025834 | Amino-functionalised ionic liquid hybrid metal-organic frameworks for carbon dioxide capture in the presence of water. | Mitigating climate change caused by global warming and achieving cost-effective and practical carbon dioxide (CO<sub>2</sub>) capture from flue gases and other diverse scenarios necessitates consideration of the impact of moisture on adsorbents. In this work, amino-functionalized imidazole ionic liquid (IL) was grafted... |
42022983 | Action Mechanism of Essential Oils or Their Components Against Pathogenic Bacteria: Literature Review. | Essential oils (EOs), derived from medicinal and aromatic plants, are natural mixtures of volatile, oily compounds with varying compositions and antibacterial mechanisms. Understanding the mechanisms of EOs and their components (EOCs) is essential for predicting their impacts on various microbes and their interactions ... |
42022965 | Diethylenetriamine-driven assembly of a dimeric cadmium bromide hybrid and an organic bromide salt: structural, vibrational, optical, <i>in silico</i> study and biological insights. | Diethylenetriamine (DET) was employed to synthesize two novel crystalline materials: a cadmium-based hybrid, (C<sub>4</sub>H<sub>16</sub>N<sub>3</sub>)[CdBr<sub>5</sub>]·H<sub>2</sub>O (DETCdBr), and an organic salt, (C<sub>4</sub>H<sub>16</sub>N<sub>3</sub>)Br<sub>3</sub> (DETBr). Single-crystal X-ray diffraction reve... |
42022958 | A ZIF-8-modified electrochemical biosensor for sensitive Aβ aggregation monitoring and Alzheimer's disease drug screening. | Alzheimer's disease (AD) is an irreversible neurodegenerative disorder driven by the abnormal aggregation of β-amyloid (Aβ) into oligomers, fibrils, and plaques. Current therapeutic strategies primarily alleviate symptoms but struggle to prevent aggregation due to the dynamic nature of Aβ species and prolonged drug dev... |
42022964 | Empowering women's health with miRNA-integrated nanochemical approaches: from reproductive health to cancer care. | MicroRNAs (miRNAs), a category of small (18-25 nucleotides) non-coding transcripts that modulate gene expression at the post-transcriptional level, are necessary for regulatory processes in female reproduction, specifically in ovarian function and follicular development. Dysregulation of these miRNAs is implicated in r... |
42022966 | Intriguing three-component four-layer stacking nanostructures formed by the self-assembly of main-chain liquid-crystalline polyurethane elastomers, as analyzed by two-dimensional small-angle X-ray scattering. | A peculiar two-dimensional small-angle X-ray scattering (2D-SAXS) pattern, exhibiting an X-shaped feature, was observed for a main-chain liquid-crystalline (LC) polymer in the uniaxially stretched state. The main-chain LC polymer examined in this study exhibits shape memory depending on temperature, which can be applie... |
42022957 | A sustainable spectrofluorimetric method for ivabradine quantification based on erythrosin B quenching with quantum mechanical modeling and Box-Behnken design optimization. | A novel, sensitive, and environmentally sustainable spectrofluorimetric method was developed for ivabradine determination based on the fluorescence quenching of erythrosin B. The method exploits the formation of a stable 1 : 1 ground-state complex between anionic erythrosin B and cationic ivabradine through electrostat... |
42022962 | High-performance activated carbons from <i>Canarium schweinfurthii</i> and <i>Ricinodendron heudelotii</i> shells for the efficient removal of indigo carmine from water. | In this study, two biomass wastes, namely, <i>Canarium schweinfurthii</i> shells (CSS) and <i>Ricinodendron heudelotii</i> shells (RHS), were converted into activated carbons by chemical activation using phosphoric acid. The two prepared adsorbents were designated as AC-CSS-H<sub>3</sub>P and AC-RHS-H<sub>3</sub>P, rep... |
42022952 | Aqueous bio-based hydrotropic solutions for green extraction of glycyrrhizic acid from licorice: experimental investigation and mechanistic insights. | Aqueous bio-based hydrotropic solutions (ABHS) were investigated as green solvents for extracting glycyrrhizic acid (GA), a major amphiphilic triterpenoid saponin from licorice. Conventional and bio-based hydrotropes were screened under ultrasound-assisted extraction, with pentane-1,2-diol (PED) identified as the most ... |
42022767 | Acridinium amidate as a hydrogen-bonding photocatalyst for direct decarboxylative alkylation of native carboxylic acids. | The direct generation of carbon radicals from carboxylic acids under visible-light photocatalysis offers an appealing strategy for molecular diversification. Here, we report a decarboxylative Giese-type addition using a zwitterionic acridinium amidate as a uniquely effective photocatalyst, which enables the efficient a... |
42022134 | Mechanistic modulation of electronic structure and interface chemistry in Ni-based alloys for electrochemical energy conversion. | Nickel (Ni) alloys are central to next generation electrocatalysts for clean energy conversion, driving key reactions such as the hydrogen evolution reaction (HER), oxygen evolution reaction (OER), and electrochemical CO<sub>2</sub> reduction. Despite extensive performance reports, the mechanistic role of alloying, how... |
42019336 | Singlet oxygen-dominated peroxymonosulfate activation by wastewater-borne copper phthalocyanine for simultaneous dye degradation and pigment recovery. | The coexistence of high-value pigment copper phthalocyanine (CuPc) and synthetic dyes in textile wastewater presents a dual challenge of environmental pollution and resource wastage. Herein, a novel singlet oxygen (<sup>1</sup>O<sub>2</sub>)-dominated self-derived catalytic system was developed to simultaneously degrad... |
42019290 | Metric-driven biosensors for analyte detection. | Protein-based biosensors are vital for environmental monitoring, diagnostics, and bioprocess control, yet many stall in the transition from laboratory to field because they fail to meet performance metrics. This review focuses on the adoption of a results-oriented, metric-driven framework focusing on (1) how molecular ... |
42015475 | Node-Activated Persulfate Reduction in a Terbium Metal-Organic Framework for Low-Potential Electrochemiluminescence and Hydroquinone Sensing. | Persulfate (S<sub>2</sub>O<sub>8</sub><sup>2-</sup>)-based electrochemiluminescence (ECL) typically requires high cathodic potentials to activate S<sub>2</sub>O<sub>8</sub><sup>2-</sup> and often suffers from inefficient utilization of short-lived radical intermediates. Here, we report a terbium metal-organic framework... |
42015308 | Predictive machine learning models for rational permeability design in de novo macrocycle engineering: a review. | Small molecule drug discovery has been highly successful across many therapeutic areas over decades of progress; however, many disease-relevant proteins remain difficult to target. In particular, intracellular proteins with large, shallow, or flexible interaction surfaces are poorly addressed by classical drug-like com... |
42014400 | Highly Efficient Removal of Tetracycline from Water Using Ce-UiO-66/Oxidized Nanodiamond Hybrids. | Tetracycline (TC) is one of the most widely used antibiotics in both human and veterinary medicine. However, its presence in ecosystems creates serious environmental concerns. This study investigates the adsorption of TC using a green-synthesized adsorbent that is composed of a Cerium-based metal-organic framework (Ce-... |
42014393 | Live-shaping of hydrogel thin films with light. | Light-responsive hydrogels are attractive materials for mimicking dynamic microstructures in nature, providing platform for tunable devices in photonics, sensing, and biomedicine. However, these systems often suffer from limited spatial resolution and slow response times, restricting their utility in high-speed or high... |
42013446 | Robust Proteinosomes with PEG Protein Mixed Corona for Enhanced Protection against Extreme pH Conditions and Trypsin Digestion. | The wide applications of proteinosomes as protocells and nanoreactors benefit from their capsule-like structures and protein functions. In regular proteinosomes, the hydrophilic protein corona can be denatured in unfavorable conditions, such as extreme pH and protease. Herein, proteinosomes with a PEG protein mixed cor... |
42013392 | Self-Assembled Phenylalanine-Derived Metabolites as Potential Neurotoxic Amyloids in Phenylketonuria. | A well-regulated metabolite concentration in biological fluids is essential for maintaining a normal physiological homeostasis. However, under conditions of metabolic imbalance, certain metabolites can accumulate and undergo self-assembly into amyloid-like supramolecular structures that may disrupt cellular functions. ... |
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