id stringlengths 4 8 | title stringlengths 1 642 | abstract stringlengths 50 17.9k |
|---|---|---|
42013155 | Morphology-Aware Peptide Discovery via Masked Conditional Generative Modeling. | Peptide self-assembly prediction offers a powerful bottom-up strategy for designing biocompatible, low-toxicity materials for large-scale synthesis in a broad range of biomedical and energy applications. However, screening the vast sequence space for categorization of aggregate morphology remains intractable. We introd... |
42013119 | QcrB inhibitor Q203 (Telacebec) can synergize with clofazimine and clarithromycin to control a Mycobacterium avium infection. | The targeting of the mycobacterial electron transport chain for drug development has recently garnered significant clinical success. The cytochrome bcc complex within the electron transport chain has emerged as a viable drug target, with the antibiotic Q203 (Telacebec) showing excellent activity against M. tuberculosis... |
42013081 | Zeolitic imidazolate frameworks (ZIF-8) as a carrier in a topical ocular delivery system for the treatment of ocular diseases. | Current systems for topical ocular drug delivery enable non-invasive administration of therapeutics to the eye but suffer from poor permeability and bioavailability, limiting therapeutic efficacy. Metal-organic frameworks are porous, crystalline materials that can serve as drug delivery systems and may improve these sh... |
42013004 | Selective Construction of <i>Pseudo</i>-Mortise-and-Tenon-Type Molecules. | Ring-in-ring complexes typically suffer from limited stability, as the interactions between the inner and outer macrocycles rely predominantly on nondirectional van der Waals forces or directional hydrogen bonding alone. To address this limitation, we identified a novel stabilization strategy based on the mortise-and-t... |
42012896 | Structurally robust quaterphenyl-dicarbonitrile 2D MOF nanopores on Cu(111) for cobalt spin-coordination motifs. | We demonstrate a strategy for fabricating robust ∼2 nm nanopores on copper (Cu) surfaces using a nonmagnetic two-dimensional (2D) metal-organic framework (MOF), without the need for additional 3d metal atom deposition, that serves as a platform for constructing single-atom transition-metal coordination sites. Scanning ... |
42012893 | Ion-Electron Coupling-Driven Redox Behavior in Metal-Organic Frameworks. | Redox-active metal-organic frameworks (MOFs) have long been proposed as electronic transport platforms, yet the microscopic origin of their conductivity remains debated. A theoretical demonstration reveals charge transport in a Zn(pyrazole-naphthalene diimide (NDI)) MOF arising not from delocalized band-like states but... |
42012878 | Design and concise synthesis of halicyclamine-inspired bis-macrocycles targeting DedA membrane proteins. | DedA membrane proteins promote the formation of double-membrane vesicles serving as replication platforms for RNA viruses, including SARS-CoV-2. Inspired by the only known inhibitor, halicyclamine A, we developed a concise biomimetic synthesis of halicyclamine-inspired macrocycles, identifying bis-macrocycles that supp... |
42012863 | A Molecular Lubrication Strategy Enabled by Propane Impurity for Self-Enhancing Its Kinetic Separation in MOFs with Diffusion-Restricted Channels. | The removal of trace alkane impurities remains challenging due to their similar molecular properties. Here we propose a self-boosting kinetic separation process enabled by a "molecular lubrication" strategy, in which trace propane acts as a dynamic lubricant within a tailored Fe-based MOF featuring a bottleneck pore st... |
42012783 | Single-Metal-Anchored 1D Mesoporous Channels to Enable Accelerated Redox Kinetics for Lithium-Sulfur Batteries. | Metal-organic frameworks (MOFs) have been demonstrated as promising separators for lithium-sulfur batteries (LSBs) owing to their highly tunable porous structures and intrinsic metal sites, which can guide uniform Li<sup>+</sup> deposition, catalyze polysulfide conversion, and suppress polysulfide shuttling. However, c... |
42012578 | Revisiting the Modification Strategies of Alloy-Base Anode for Solid-State Lithium-Ion Batteries Through Deconstructing Anode-Interface-Solid Electrolyte. | In recent years, advanced battery systems based on solid electrolytes have become a research hotspot to replace traditional liquid lithium-ion batteries due to their significant advantages in energy storage performance and safety. The alloy anode materials (such as Si, Sn, and P) have attracted much attention due to th... |
42012571 | Clinical nuclear medicine applications of zirconium-89 immuno-PET: a comprehensive review from a radiopharmaceutical perspective. | <h4>Background</h4>Immuno-positron emission tomography (immuno-PET) imaging is emerging as a highly promising technique for the non-invasive diagnosis of a wide range of pathological conditions, particularly in oncology and immunology. This molecular imaging modality enables the visualization, characterization, and qua... |
42012552 | UiO-66-NH₂-catalyzed biodiesel production: mechanistic insights from molecular dynamics simulation. | <h4>Context</h4>To elucidate the performance mechanisms and limiting factors of UiO-66-NH₂ in catalyzing biodiesel production from waste oil at the molecular level, this study integrates experimental investigation with molecular dynamics (MD) simulations. Initially, UiO-66-NH₂ with high crystallinity and octahedral mor... |
42012325 | Micelle Fibrillization, Gelation, and Mechanical Property Tuning of a Green, Stimuli-Responsive, and Na<sup>+</sup> Ion-Specific Low-Molecular-Weight Amino Acid-Based Cationic Surfactant─Hofmeister and Ionic Strength Effects. | A novel low-molecular-weight hydrogel (LMWH) was designed through the intricate process of molecular self-assembly of a biocompatible and biodegradable N<sup>α</sup>-lauroyl-l-arginine methyl ester, a cationic arginine-based surfactant, abbreviated as LAM. Transitioning from spherical to smart worm-like micelles (SWLM)... |
42012261 | In silico evaluation of imidazopyridine compounds targeting ACE2: molecular dynamics and binding energy analysis. | Angiotensin-converting enzyme 2 (ACE2) regulates cardiovascular function and serves as the SARS-CoV-2 entry receptor, making it a dual therapeutic target. Most drug development focuses on the virus rather than exploring broader host-directed protective strategies. We hypothesize that imidazopyridine derivatives may ser... |
42012059 | Concentration-Responsive Gd-DOTA Nanomicelles via Chain-Length Engineering for Transporter-Independent Hepatobiliary Magnetic Resonance Imaging. | Balancing the thermodynamic stability and biological clearance of supramolecular assemblies represents a fundamental challenge in the design of functional nanomedicines. To address this, we propose a concentration-responsive "assemble-for-uptake, disassemble-for-clearance" strategy implemented via rational molecular en... |
42012063 | Peptide dendritic polymerization-enabled stable and tailorable nanoparticles as crosslinkers for fabricating multifunctional hydrogels with enhanced wound healing efficacy. | Developing biomedical nanomaterials that seamlessly integrate structural stability, precise modifiability, and inherent biocompatibility remains a significant challenge. Peptides are ideal candidate building blocks for constructing biocompatible nanomaterials. However, traditional peptide assembly often relies on weak ... |
42011962 | One Porous Metal-Organic Framework Containing Multinuclear Clusters and Functional Groups for Purification of Acetylene and Ethylene. | For the critical yet challenging industrial processes of the selective removal of trace acetylene (C<sub>2</sub>H<sub>2</sub>) from ethylene (C<sub>2</sub>H<sub>4</sub>) and the separation of C<sub>2</sub>H<sub>2</sub> from carbon dioxide (CO<sub>2</sub>), we herein report the rational design and synthesis of a novel h... |
42011896 | Enantioselective Induction of Immunogenic Cell Death: A Type-I Photodynamic Therapy Enabled by Chiral Porphyrin/Arginine Self-Assemblies. | The development of chiral type-I photosensitizers represents a significant advance, as it can not only overcome the hypoxia limitation inherent to conventional type-II agents but also leverage enantioselectivity to enhance therapeutic precision. However, this promising field remains notably underexplored. Herein, we co... |
42011886 | Highly Water-Stable and Visible-Light-Responsive Ag@Al-TCPP MOFs for Enhanced Photochemical Transformation of Tetracycline. | In this study, a series of Ag@Al-TCPP metal-organic frameworks (MOFs) with uniformly dispersed, small-sized silver nanoparticles (Ag NPs) on starfruit-shaped porphyrin Al-MOFs were fabricated through a facile two-step process involving hydrothermal and solvent-assisted thermal reduction methods. Benefiting from the exc... |
42011847 | Shellac-Mediated Assembly of Nanoparticles for mRNA Delivery. | Cationic polymers have been extensively explored for messenger RNA (mRNA) delivery owing to their ability to condense nucleic acids and facilitate cellular uptake. High-molecular-weight polymers typically achieve high transfection efficiency but exhibit substantial cytotoxicity, whereas low-molecular-weight polymers sh... |
42011845 | Tailoring Avidity through Morphology: Structure-Avidity Relationship in CD38-Binding Nanofiber Radiotracers. | The lack of targeted molecular imaging agents for multiple myeloma (MM) hinders precise disease characterization and theranostic development. We address this by engineering a tunable platform of self-assembled peptide nanofibers that target CD38, a key antigen in MM. Simple variation of a conjugated lipid tail length (... |
42011834 | Engineering Ultrahigh-Contrast Photoactivated Room-Temperature Phosphorescence With a Robust and Universal Ureido-Functionalized Siloxane Network. | Photoactivated room-temperature phosphorescence (pRTP) host-guest systems have received widespread attention due to their non-invasive photoresponsiveness, high reversibility, and color tunability. However, traditional polymer hosts often lack efficient photoactivation and sufficient stability due to passive oxygen pen... |
42011831 | Effects of Molecular Aggregation on Dynamic Third-Order Nonlinear Optical Responses: Oligo(thiophene-benzothiadiazole) as a Case Study. | Nonlinear optical properties of molecular materials are governed by aggregation and cooperative effects in the condensed phase, requiring first-principles simulations on large molecular assemblies to achieve a realistic description of experiment. While modern electronic-structure theory implementations mitigate key com... |
42011819 | Electroactive Metal-Organic Frameworks Enabling Unidirectional Electrochemical Capacitors and Logic Gates (MOF-CAPode). | From concept to realization, the integration of porous redox-active metal-organic frameworks (MOFs) into asymmetric electrochemical capacitors for the assembly of electrochemical capacitor-diodes (CAPodes) is reported. CAPodes are innovative electrochemical capacitor analogues of diodes, designed for unidirectional cha... |
42011811 | Leveraging Glycan-Glycan Interactions to Tune the Conformation of Glycan Hairpins and Build Rigid 3D Architectures. | Glycan folding and aggregation remain poorly understood despite their essential roles in structural and biological functions. We present a reductionist approach leveraging a glycan sequence that spontaneously folds into a hairpin conformation, enabling the systematic analysis of glycan intra- and intermolecular interac... |
42011812 | Interfacial Charge-Regulated Microenvironments Enabled by Ionic Organic Cages for Boosting Electrocatalytic Nitrate Reduction to Ammonia. | Ammonia (NH<sub>3</sub>) is essential for agriculture and industry, yet the Haber-Bosch process is energy-intensive and carbon-emissive. Electrochemical nitrate reduction reaction (NO<sub>3</sub>RR) offers a sustainable alternative by coupling NH<sub>3</sub> synthesis with water remediation. However, challenges such as... |
42011737 | A fluorinated zirconium metal-organic cage-based supramolecular framework for efficient separation of methanol-to-olefin (MTO) products. | The separation of C<sub>2</sub>H<sub>4</sub> and C<sub>3</sub>H<sub>6</sub> is of great significance in the methanol-to-olefin (MTO) process. In this study, a fluorinated zirconium metal-organic cage-based supramolecular framework, NUT-107, with permanent porosity was developed. This material exhibits high C<sub>2</sub... |
42011711 | Tandem Guest-Host Switching for Chemical-to-Electrochemical Signal Transduction. | A chemical-to-electrochemical signal transduction is reported based on the tandem switching of a bis-acridinium macrocycle and a proflavine derivative. Molecular recognition triggers a simultaneous guest-host transformation converting the acridinium units into their redox-inactive acridane counterparts. This unusual sw... |
42011733 | Preliminary study on targeted nanoparticles co-loaded with piperine and paclitaxel prodrug for ovarian cancer treatment. | Combination chemotherapy incorporating natural products has emerged as an effective strategy to enhance anticancer efficacy while reducing systemic toxicity. Based on this, our study report a targeted, stimuli-responsive nanoparticle system for the co-delivery of paclitaxel (PTX) and piperine (PIP) to achieve synergist... |
42011730 | Intrinsically Conductive π-d Conjugated Layers with Co-N<sub>4</sub> Active Sites for Efficient Nitrate Electrocatalysis and Zinc-Nitrate Batteries. | Electrochemical synthesis of ammonia from nitrate has been extensively investigated as a potential alternative to the energy-intensive Haber-Bosch process. This approach not only operates under ambient conditions but also simultaneously removes nitrate contaminants while producing ammonia as a value-added product. Howe... |
42011701 | Porphyrins as Novel Therapeutics for HIV: Mechanism, Advances, and Challenges. | Porphyrins, a class of heterocyclic macrocycles, have garnered significant attention for their potential antiviral properties, particularly against human immunodeficiency virus (HIV). This review explores how porphyrins and their derivatives inhibit HIV replication, focusing on their interactions with key viral compone... |
42011543 | Engineered Co<sub>3</sub>O<sub>4</sub> nanoboxes boost luminol chemiluminescence for selective Mn<sup>2+</sup> sensing. | Chemiluminescence (CL) is a powerful analytical tool that has gained increasing interest in various fields due to its rapid response, simplicity, cost-effectiveness, and higher sensitivity compared to traditional complex methods for detecting trace toxic metals. The traditional luminol/H<sub>2</sub>O<sub>2</sub> CL met... |
41973077 | Spin dynamics in Ru<sup>III</sup>-oxalate complexes: synthesis, characterization, and a<i>b initio</i> insights. | Neutral 1D chains [RuCl<sub>2</sub>(μ-ox)<sub>2</sub>Ln(H<sub>2</sub>O)<sub><i>x</i></sub>(dmf)<sub>4</sub>]<sub><i>n</i></sub> [Ln = La, <i>x</i> = 1 (2); Ln = Dy, <i>x</i> = 0 (3)] were obtained by self-assembly from LnCl<sub>3</sub>·<i>n</i>H<sub>2</sub>O and (PPh<sub>4</sub>)<sub>2</sub>(H<sub>3</sub>O)[RuCl<sub>2<... |
41944056 | Design of hybrid steric α-diimine nickel precatalysts with intramolecular π-π interactions for the synthesis of polyethylene elastomers. | A series of hybrid steric α-diimine Ni(II) precatalysts incorporating a rigid diarylmethyl group and a flexible isopropyl substituent were designed and synthesized for ethylene polymerization. Single-crystal X-ray diffraction analyses revealed intramolecular offset π-π stacking between the electron-deficient acenaphthe... |
41943896 | Fe-doped NiCoP nanosheet arrays rich in phosphorus vacancies for highly efficient electrochemical water splitting. | Transition metal phosphides (TMPs) have emerged as highly active bifunctional electrocatalysts, owing to their excellent conductivity and tunable electronic structure. However, a major bottleneck for TMP-based catalysts is their limited active-site accessibility and insufficient operational durability, which together i... |
41914780 | Ultrasonication-induced Co-based metal-organic framework nanoparticles for red-light photocatalytic aerobic oxidation. | Herein, we successfully obtained a two-dimensional (2D) Co(II) metal-organic framework, [Co<sub>2</sub>(PDPA)(H<sub>2</sub>O)<sub>8</sub>]<sub><i>n</i></sub> (XAIU-4), by using Co(NO<sub>3</sub>)<sub>2</sub>·6H<sub>2</sub>O and 5,5'-(phenazine-5,10-diyl)diisophthalic acid (H<sub>4</sub>PDPA). Single-crystal X-ray diffr... |
41914465 | Host-guest adsorption energetics in functionalized UiO-66 nanocrystals for selective VOC sensing. | Volatile organic compounds (VOCs), such as formaldehyde (HCHO) and acetone (C<sub>3</sub>H<sub>6</sub>O), are ubiquitous air pollutants in industrial and indoor environments and pose serious risks to human health, driving demand for selective, sensitive detection. Metal-organic frameworks (MOFs) are promising sensing n... |
41910737 | La-[<sup>18/19</sup>F]fluoride complexes: a novel addition to the radiofluorination family. | Here, we report the synthesis and evaluation of La-[<sup>18/19</sup>F]fluoride coordination complexes with macrocyclic ligands, expanding the family of metal-[<sup>18</sup>F]fluoride coordination species for PET imaging applications. Fluorination of a series of La complexes with macrocyclic chelators (L = DOTA, DOTAM, ... |
41906683 | Efficient one-step SO<sub>2</sub> capture from industrial flue gas <i>via</i> a scalable Zr-based metal-organic framework. | Industrial exhaust gas containing trace SO<sub>2</sub> can cause severe corrosion of equipment and pose significant environmental risks. Therefore, developing high-performance adsorbents for efficient SO<sub>2</sub> capture is of great importance. Herein, MOF-801(Zr), obtained <i>via</i> our in-house green synthetic ap... |
41889351 | Recent progress on MN<sub>4</sub> macrocycle-derived oxygen reduction reaction electrocatalysts for polymer electrolyte fuel cell applications. | Transportation and power generation sectors have been garnering strong support for fuel cell-based technologies in recent times for emission-free energy conversion. However, the performance of these devices largely relies on the costly and scarce Pt-group metal-based electrocatalysts, which hinder their widespread comm... |
41885603 | Coordination-driven supramolecular metalla-cycles/cages for next-generation antibacterial therapy. | Bacterial resistance has become a critical global health threat, demanding innovative non-antibiotic strategies. Coordination-driven self-assembly provides a powerful approach for constructing metal-organic macrocycles and cages (MOMs/MOCs) with precisely defined cavities, tunable charge distributions, and multifunctio... |
41834582 | Modular noncovalent functionalization of electrospun piezoelectric scaffolds with bioactive nanocarriers. | Electrospun scaffolds offer a promising platform for immune-instructive materials, but stable and modular functionalization with bioactive signals remains a technical challenge. Here, we develop a surface coating strategy for electrospun scaffolds that consist of poly(vinylidene fluoride-trifluoroethylene) (PVDF-TrFE),... |
42034930 | Target-induced coordination effect mediated the oxidase-like activity of Ph-Ag nanoparticles for enzyme-free and rapid sensing of propiconazole pesticide. | It is of high importance yet a challenge to devise a sensor for direct and rapid sensing of pesticides based on a target-mediated nanoenzyme activity strategy. Herein, we design an effective colorimetric sensor for enzyme-free and rapid sensing of propiconazole (PC) pesticide based on the target-induced coordination ef... |
42034926 | Advancing chloramphenicol detection through a novel porous organic polymer-enhanced screen-printed electrode. | This study explores the synthesis and characterization of a novel cationic porous organic polymer (cPOP, referred to as POP1) designed as an active material for electrochemical detection of chloramphenicol (CAP) in complex matrices. Unlike conventional sensing platforms, POP1 provides a high density of accessible adsor... |
42030850 | A photoelectrochemical sensor array based on MOF nanozymes for the identification and detection of phenolic compounds. | The wide variety of phenolic compounds, along with their similar structural features and physicochemical properties, poses significant challenges for reliable identification and detection. This article develops a novel photoelectrochemical (PEC) sensor array based on three metal-organic framework (MOF) nanozymes with s... |
42030717 | Integrated decontamination of off-odors and ammonia nitrogen in aquaculture using a core-satellite MOF-on-MOF heterostructure. | Off-odors in aquatic products reduce marketability, while aquaculture ammonia emissions exacerbate eutrophication, impeding sustainable industrialization. Herein, we report a surfactant-mediated epitaxial growth strategy to construct a core-satellite CDMOF-on-CaMOF heterostructure, which features ordered anchoring and ... |
42030673 | Moisture-triggered one-step encapsulation of cinnamaldehyde in β-cyclodextrin for humidity responsive release and food preservation. | This study developed a novel one-step strategy to encapsulate cinnamaldehyde (CIN) into β-cyclodextrin (β-CD) via moisture-triggered recrystallization. By precisely regulating the moisture content (17% MC) of spray-dried amorphous β-CD, controlled recrystallization was achieved, simultaneously facilitating CIN inclusio... |
42028329 | Xanthene-to-fluorene skeletal editing <i>via</i> oxygen deletion mediated by boron and aluminium radicals. | Single-atom skeletal editing <i>via</i> selective oxygen deletion from diarylethers remains an underdeveloped transformation, despite its potential to directly access new carbon frameworks. Here, we report a boron- and aluminium-mediated <i>O</i>-deletion reaction that converts xanthene and diphenylether motifs into fl... |
42025055 | Elucidating the nanointerface-enabled enzymatic cascade amplification mechanism for a precise self-powered strategy. | This study pioneers a enzymatic biofuel cell that fundamentally redefines portable detection of sugarcane pokkah boeng disease through synergistic nanomaterial engineering and molecular circuitry design. As a single-enzyme architecture, Exo III-mediated molecular circumvents nonspecific interference inherent in multi-e... |
42019900 | Supramolecular dynamic hydrogels loaded with bevacizumab nanoparticles promote hyaline cartilage regeneration by inhibiting angiogenesis. | After joint cartilage injury, due to abnormal vascular invasion, the repaired tissue often forms fibrous cartilage with poor mechanical properties, not matching normal articular hyaline cartilage. The overexpression of vascular endothelial growth factor (VEGF) is considered a significant cause of hyaline cartilage repa... |
42019859 | All-silk fibroin-based dual-drug delivery system for antibacterial and antioxidant wound repair. | Chronic and contaminated wounds are characterized by concurrent bacterial infection and excessive reactive oxygen species (ROS), necessitating biomaterials capable of coordinated antimicrobial and antioxidant regulation. In this study, we developed an all-silk fibroin-based dual-drug delivery system through macromolecu... |
42017157 | Sn-MOF/Zn-MOF composite electrode with interfacial synergy for high-performance battery-supercapacitor hybrid devices. | The growing demand for reliable and high-performance energy storage devices obliges the development of novel materials that can merge high energy density with rapid charge-discharge capability. Hybrid supercapacitors offer this balance, while MOFs are recognized as promising electrode candidates due to their high surfa... |
42017049 | Eigenvalue Ratios Reveal Shared Binding Pocket Shapes in RNA and Protein Structures. | Molecular recognition in drug design relies on accurate characterization of ligand-binding pockets on macromolecular targets such as proteins and RNA. While protein binding sites have been extensively described, the geometric organization of RNA pockets remains comparatively underexplored. Here, we introduce a unified ... |
42016526 | Navigating the <i>Nanoverse</i>: how emerging nanomaterials are transforming bioscience and society. | The rapid expansion of nanomaterials research has given rise to the concept of the <i>Nanoverse</i>, a multidisciplinary shared domain where increasingly sophisticated nanoscale architectures address societal challenges while introducing new safety and sustainability questions. This review writes up recent advances acr... |
42016510 | Deciphering the Chemotherapeutic Mechanism of Ferulic Acid: Insight Into the Role Against Multiple Human Cancers. | Extensive research continues to address the challenges of developing standard cancer drugs. However, until more effective standard drugs are developed, ferulic acid (FA) may be a potential option for controlling the symptoms of cancer patients. According to our review, FA is available in natural sources and has flexibl... |
42013670 | ZrO<sub>2</sub>@C-MOF-808: A carbonized MOF-Based nanocomposite for sensitive electrochemical detection of ulipristal acetate. | To the best of our knowledge, this study presents the first electrochemical sensing platform for the selective determination of ulipristal acetate (UA), based on a ZrO<sub>2</sub>@C-MOF-808 nanocomposite-modified glassy carbon electrode (GCE) for applications in biological and pharmaceutical samples. The ZrO<sub>2</sub... |
42013660 | TEMPO-oxidized cellulose nanofiber/chitosan composite films stabilized by cumin essential oil-loaded Pickering emulsions for multifunctional food preservation. | Designing multifunctional packaging films that combine barrier protection, antimicrobial activity, antioxidant capacity, and controlled-release functionality is crucial for extending the shelf life of perishable foods. This study presents the first incorporation of cumin essential oil-loaded Pickering emulsions into a ... |
42010962 | High-Current Oxygen Evolution via Synergistic Ag Incorporation in Zn-Based Metal-Organic Framework Electrocatalysts. | Ag-Zn bimetallic metal-organic frameworks (Ag<sub>x</sub>Zn<sub>1-x</sub>-MOFs) were grown on NiFe alloy foam (NFF) via a one-step hydrothermal route. The optimized Ag<sub>10</sub>Zn<sub>90</sub>-MOF/NFF requires overpotentials of only 220, 369 and 439 mV at 10, 1000 and 2000 mA cm<sup>-2</sup>, respectively, with stab... |
42010958 | Stable Au(III) Benzohomoporphyrin: Synthesis, Structure, Near-Infrared Absorption, and Superoxide Radical Generation. | Two Au(III) tetrapyrrole complexes were obtained from the reaction of a bent-shaped benzohomoporphyrin ligand and Au(III) acetate. Despite the small size of the tetrapyrrolic ligands, the Au(III) complexes exhibited a low-energy NIR absorption. Combined density functional theory and TDDFT calculations with natural tran... |
42010885 | Chiral Self-Sorting Assembly of Au<sub>16</sub> Rings for Cancer Therapy via Enantioselectivity-Induced Ferroptosis and Apoptosis. | Chirality-induced biochemical response has emerged as a prominent research focus. This research demonstrates the chiral self-sorting assembly of atomically precise Au<sub>16</sub> supramolecular rings via aurophilic interactions. Enantiomers (M<sub>R,R</sub>M'<sub>R,R</sub>)-Au<sub>16</sub>Cl<sub>8</sub> and (P<sub>S,S... |
42010868 | Solvent-Controlled Pathways Enable Structure-Programmable Metal-Organic Framework Membranes for Isomer Separation. | The separation of structurally similar aliphatic and aromatic isomers remains a critical industrial challenge, as their nearly identical sizes render conventional distillation highly energy-intensive. Molecular-sieving metal-organic framework (MOF) membranes offer an energy-efficient alternative; however, reliably prog... |
42010821 | Mechanistic Study on the Mechanism and Origins of Reactivity for the Metal-Organic Cage-Catalyzed Knoevenagel Condensation under Neutral Conditions in Water. | Understanding how supramolecular confinement enhances carbon-carbon bond formation under neutral aqueous conditions remains a central challenge in cage-based catalysis. Herein, we present a density functional theory (DFT) study of the Knoevenagel condensation between naphthaldehyde and Meldrum's acid in bulk water and ... |
42010721 | Reengineering statin therapy to protect skeletal muscle: nanocarrier strategies for mitigating mitochondrial dysfunction and myotoxicity. | Statins remain the cornerstone of atherosclerotic cardiovascular disease prevention; however, their long-term clinical utility is frequently limited by skeletal muscle toxicity, ranging from mild myalgia to severe myopathy. Growing evidence implicates mitochondrial dysfunction, oxidative stress, and impaired muscle ene... |
42010649 | A Cu-based metal-organic framework based on desloratadine and siHIF-1α for achievement of genes/drugs/CDT combination therapy in hepatocellular carcinoma. | <h4>Background</h4>Desloratadine (DL) has been demonstrated to inhibit NMT1 enzymatic activity, thereby promoting oxidative stress and endoplasmic reticulum (ER) stress to induce cancer cell death. However, the lack of tumor targeting limits its therapeutic efficacy. The combination of siRNA technology and nanotechnolo... |
42010392 | Volcano Plot of Transition Metal Disulfides in Aqueous Zinc Ion Storage. | The rational design of cathode materials for aqueous zinc-ion batteries (AZIBs) has been guided by the principle that larger interlayer spacing facilitates greater Zn<sup>2+</sup> storage. However, this geometric heuristic fails to explain the stark performance difference between isostructural transition metal disulfid... |
42010369 | Development of Venlafaxine Hydrochloride Nasal Thermosensitive In-Situ Gel with P407/P188: Enhanced Bioavailability and Antidepressant Effects in Depressive Rats. | <h4>Objective</h4>To develop and optimize a VEN nasal thermosensitive in-situ gel for reducing first-pass effect and enhancing bioavailability.<h4>Methods</h4>High performance liquid chromatography, central composite design-response surface methodology, the membrane-free erosion and the Franz vertical diffusion cell me... |
42010367 | Associations of Semaglutide With Skeletal Outcomes in People With Obesity, With and Without Type 2 Diabetes: A Target Trial Emulation. | <h4>Aims</h4>To evaluate the associations between semaglutide initiation and long-term skeletal outcomes in people with obesity, stratified by type 2 diabetes (T2D) status, using target trial emulation.<h4>Materials and methods</h4>This retrospective cohort study used the TriNetX federated electronic health record netw... |
42010307 | Methodological guidelines for P2X receptor assays and data interpretation. | P2X receptors (P2XR) are a family of seven cation channels gated by extracellular ATP (eATP). Activation of P2XRs results in diverse cellular responses, including cell signalling, proliferation, differentiation, and death-all critically important in multiple physiological and pathophysiological states. These receptors,... |
42010207 | p-Sulfonatocalixarene-Based Complexation Mitigates Hepatorenal Toxicity of Anticancer Alkaloids without Loss of Efficacy: A Strategy for Selective Detoxification. | p-Sulfonatocalix[n]arenes (SCnA, where n = 6, 8) have emerged as promising supramolecular hosts for encapsulating active pharmaceutical ingredients (APIs) through host-guest complexation, enhancing solubility, stability, and bioavailability. In this study, SCnA was employed to complex hepatotoxic and nephrotoxic alkalo... |
42009775 | Ligand binding modes of the bitter taste receptor T2R14 and T2R46. | Bitter taste receptors (T2Rs) are considered attractive drug targets. However, the ligand recognition and selectivity of these receptors remain elusive, hampering their drug development. Here we present seven structures of human T2R14 and T2R46 in apo or ligand-bound state. Combined with molecular docking and mutagenes... |
42009517 | Rational Protein Molecular Design of Hydrophobic Interior-Modified Ferritin Enables Efficient Lycopene Delivery for Ameliorating Aging-Related Cognitive Impairment. | Lycopene shows potential against aging-related cognitive decline but suffers from poor stability, low blood-brain barrier penetration, and inefficient delivery. Native rHuHF is biocompatible yet achieves only ∼6% lycopene encapsulation due to its hydrophilic cavity. Here, a recombinant mutant human heavy-chain ferritin... |
42009409 | Composition-Dependent Li-Ion Transport in Mixed-Metal ZIF-62 Glasses Revealed by Machine-Learning Molecular Dynamics. | Understanding ion transport in metal-organic frameworks requires resolving the interplay between framework dynamics, local disorder, and thermally activated hopping on extended time and length scales. Here, we develop a robust deep neural network (DNN) interatomic potential, trained and validated against density functi... |
42009316 | Self-Assembly of Hierarchical Macroporous Metal-Organic Framework Films Guided by Hydrophilic-Lipophilic Balance. | Metal-organic framework (MOF) films possess versatile chemical functionalities, intrinsic microporosity, and facile integration with surfaces and devices, generating significant interest across diverse fields. However, precise control over large-area MOF films with hierarchical micro- and macroporosity remains challeng... |
42008555 | A Host-Guest-Regulated Photocurrent Polarity Switching with a "Binary" Strategy for False-Positive-Free Microbial Detection of <i>Staphylococcus aureus</i>. | Herein, we report a supramolecular photoelectrochemical (PEC) biosensor based on a signal-polarity-inversion strategy, integrated with bacterial imprinting technology, for the ultrasensitive and selective detection of <i>Staphylococcus aureus</i> (<i>S. aureus</i>). The biosensor is constructed by embedding <i>S. aureu... |
42008482 | Computational investigation of African natural products as Helicobacter pylori shikimate kinase inhibitors. | Helicobacter pylori is one of the most prevalent bacteria, infecting more than 40% of the world's population. Rising antibiotic resistance has created an urgent need for the discovery of novel therapeutic agents. One of the potent drug targets for H. pylori is shikimic acid pathway, which synthesizes chorismate, an ess... |
42008318 | Benchmark Low-Pressure Ethane Uptake for Ethylene Purification Enabled by a Metal-Organic Framework with Confined Pore Space and Abundant Binding Sites. | Removing trace ethane (C<sub>2</sub>H<sub>6</sub>) from ethylene (C<sub>2</sub>H<sub>4</sub>)-rich streams is essential for high-purity C<sub>2</sub>H<sub>4</sub> production but remains energy-intensive due to their similar physicochemical properties. Adsorptive separation using metal-organic frameworks (MOFs) offers a... |
42008304 | Matrix-Free, Supramolecularly Assembled PANI/HEDP/Lignosulfonate Hydrogel Electrodes for Advanced Flexible Supercapacitors. | Conductive polymer hydrogels for flexible supercapacitors usually contain nonconductive matrices (e.g., PVA, PAM), which hinder the electrochemical performance. This work presents a matrix-free strategy via supramolecular self-assembly, utilizing HEDP as a dual-functional dopant/cross-linker and lignosulfonate (LS) as ... |
42008792 | Synergistic Zn and Graphene Oxide Enable High-Entropy MOF-74 Nanorods for Multi-Anodic Electrocatalysis. | While morphological control in metal-organic frameworks (MOFs) has been widely explored, the extension of this concept to compositional engineering and precise anisotropic growth in high-entropy systems has only recently emerged. Herein, we present the first synthesis of one-dimensional single-crystal HE-MOF-74 nanorod... |
42008698 | CRISPR/dCas9-Assisted On-Bead Multiplex Detection (BeadPlex2) for Genetically Modified Crops. | This study leverages the precise recognition ability of CRISPR/dCas9 and the Raman coding feature of the gap-enhanced Raman tag-encoded magnetic beads (MagGERTs) to create a unique on-bead nucleic acid detection platform (BeadPlex2) for accurate and multiplex nucleic acid detection, which was proven to be applicable fo... |
42008657 | Geometry-Governed Symmetry-Breaking Charge Separation and Photocatalysis of Benzoperylenetriimide Dimers. | An in-depth understanding of the structure-property relationships in multichromophoric systems undergoing excited electron transfer is essential for designing reliable photocatalytic and optoelectronic devices. However, creating architectures to govern electron-transfer events in a controlled manner remains challenging... |
42008597 | Effect of HIV-1 subtype-specific Tat protein polymorphisms on Tat-TAR interaction. | <h4>Introduction</h4>HIV Tat protein is responsible for HIV replication activation and interacts with the TAR RNA element for its function. Genetic polymorphisms in the Tat protein sequence can affect its interaction with the TAR element. Previous studies focusing on HIV subtypes B and C found that substitutions such a... |
42008168 | Development and external validation of prediction models for major osteoporotic fracture and hip fracture in people with intellectual disability. | People with intellectual disability (ID) have a relatively high incidence of fractures, so current risk prediction models are not appropriate. A new prediction model for people with ID showed good calibration and discrimination in external validation. This is the first such prediction model developed for people with ID... |
42008164 | The systemic inflammation response index is independently associated with incident fracture risk in older women. | This study investigated the link between the systemic inflammation response index (SIRI) and fracture risk in elderly women. Higher SIRI was associated with increased fracture risk, independent of clinical risk factors and bone mineral density, suggesting SIRI may be valuable for enhancing fracture risk assessment mode... |
42008119 | Enhanced antibiofilm activity of environmental bacteriophages in combination with antibiotics against relevant Gram-negative pathogens. | <h4>Aims</h4>The aim of this study was to assess the antimicrobial and antibiofilm activity of wastewater bacteriophages in combination with conventional drugs against relevant Gram-negative pathogens in vitro.<h4>Methods and results</h4>Host bacterial strains (Stenotrophomonas spp, Burkholderia spp, and Achromobacter ... |
42008023 | Identification and Experimental Validation of Biomarkers Associated with PI3K/AKT Signaling Pathway in Spinal Cord Injury. | Spinal cord injury (SCI) refers to trauma to the spinal cord resulting in functional deficits. Dysregulation of the phosphoinositide 3-kinase/serine-threonine kinase (PI3K/AKT) pathway significantly contributes to the pathogenesis of SCI. This study evaluated the role of PI3K/AKT-associated biomarkers in SCI. Transcrip... |
42007957 | Current and emerging therapeutic advancements for Niemann-Pick disease type C: where are we now and what does the future hold? | <h4>Introduction</h4>Niemann-Pick Disease Type C (NPD Type C) is a rare lysosomal disease characterized by progressive neurovisceral manifestations due to abnormal lipid storage resulting from biallelic mutations in the NPC1 or NPC2 gene. Until recently, treatment was mainly symptomatic.<h4>Areas covered</h4>This revie... |
42007939 | Portable multichannel immunoassay of coxsackievirus A6 using a coordination-engineered iridium-doped ZIF-8 nanozyme. | Developing multifunctional nanozymes with well-defined catalytic mechanisms is of considerable interest for analytical sensing applications. Herein, an iridium-doped ZIF-8 nanozyme was developed as a multifunctional signal tag for portable multichannel immunoassay of coxsackievirus A6 (CVA6). The introduction of iridiu... |
42007925 | Continuous flow synthesis of MOF/nanocarbon composites. | Zirconium-based metal-organic frameworks (Zr-MOFs), such as UiO-66-NH<sub>2</sub>, exhibit high surface areas and chemical stability, while graphene provides unique electrical properties and high mechanical strength. Hence, nanocomposites that integrate graphene into Zr-MOFs can enhance interfacial charge transfer and ... |
42007833 | Cationic Permethylated Cyclodextrins Capable of Self-Assembling Into Linear Nanostructures in Water. | A highly diastereoselective synthesis of cationic permethylated α- and β-cyclodextrins (α-CDs and β-CDs), incorporating a quaternary ammonium unit bridging two adjacent glucose units, has been developed. This novel methodology provides access to amphipathic α-CDs equipped with an outward-facing alkyl chain, which self-... |
42007728 | Pan-genomic insights into resistance, virulence, and stress adaptation in <i>Clostridium perfringens</i> from the Tibetan Plateau. | <i>Clostridium perfringens</i> is a ubiquitous foodborne and zoonotic pathogen responsible for necrotizing enteritis, food poisoning, and gas gangrene in humans and livestock, with mortality reaching 100% in specific subtypes. The Qinghai-Tibetan Plateau, with its high altitude, hypoxia, large temperature fluctuations,... |
42007611 | Stiffness Reinforcement in Polymer Networks Through Supramolecular Topological Linking. | Polymer networks possess numerous elastically defective and isolated loops, which do not contribute to mechanical stiffness. In this report, we introduce a strategy of supramolecular topological linking to access stiffer-yet-ductile polymeric materials through incorporation of supramolecular tetravalent crosslinkers. D... |
42007638 | High-Throughput Screening for Practical Applications of Metal-Organic Frameworks to Advanced Water-Based Thermal Storage Technologies. | The development of efficient adsorbents for water-based adsorption thermal energy storage (ATES) is essential for the large-scale utilization of low-cost and renewable energy, as the performance of these systems highly depends on the choice of adsorbent-water working pair. While metal-organic frameworks (MOFs) have att... |
42007506 | DNA Condensates Enable Crosstalk-Free Operation of Identical DNA Computing Cascades. | DNA strand displacement reactions (SDR) have enabled the development of biosensing devices, molecular machines, and molecular computing. However, the need for high sequence orthogonality poses a major challenge to the modular integration and scaling of DNA SDR networks into more complex systems capable of advanced or p... |
42003819 | A Biomimetic Nanoparticle System Intercepts and Degrades Thrombospondin-1 to Restore Vascular Homeostasis After Ischemic Injury. | The thrombospondin-1 (TSP-1)/CD47 signaling axis plays a critical role in endothelial injury during hepatic ischemia-reperfusion (IR). Targeting this pathway represents a promising strategy to prevent liver IR injury; however, existing CD47 antagonists cause severe hematologic side effects due to nonspecific binding to... |
42003804 | Tyrosinase Driven-Intracellular Polymerization of a Porphyrin Derivative Induced Immunogenic Death of Melanoma Cells and Strengthened Photodynamic Therapy. | Therapeutic agents usually must reach diseased tissue and then exert biological effects. While numerous targeted and stimuli-responsive delivery systems have been developed, their therapeutic outcomes have been limited due to the lack of "precision". In this study, we present a strategy for in situ polymerization of a ... |
42003793 | Dual Physiological Barriers Bypassed by a Silk-Based Supramolecular Protein Delivery Platform for Neuroinflammation Mitigation in Alzheimer's Disease. | Delivering protein therapeutics to the brain through nanocarriers requires overcoming both the blood-brain barrier (BBB) and intracellular lysosomal degradation. Here, we report a silk-based supramolecular protein delivery platform that addresses these dual physiological barriers. Two phenolic compounds are grafted ont... |
42003768 | Cucurbit[8]Uril Achieved Single-Molecule Chiral Transfer to Supramolecular Circularly Polarized Luminescence. | Herein, cascaded supramolecular assembly was constructed from phenylalanine-modified biphenyl-pyridine derivatives (L/D-FPy), cucurbit[8]uril (CB[8]), and amphipathic sulfonatocalix[4]arene (SC4AD), which not only exhibits cascaded energy transfer and chiral transfer but also achieves amplified circularly polarized lum... |
42003752 | Simultaneous Capture and Luminescent Detection of Trace Benzene in Cyclohexane Enabled by π-Accepting Benzothiadiazole Units in a Metal-Organic Framework. | The separation and detection of trace benzene in cyclohexane is a challenging task in the chemical industry due to its nearly identical physical properties. Herein, we report a tailored metal-organic framework (MOF), <b>NIIC-66</b>, which simultaneously addresses both challenges through a synergistic combination of mol... |
42003735 | Sequential, Multistep, and Cooperative Helicity Evolution in Supramolecular Polymers of Chlorophyll Rosettes. | Helicity is a fundamental structural principle that imparts order and function to biological systems, with many biological assemblies exhibiting helical architectures that often emerge and mature dynamically over time, enabling adaptive structural transformations and functional regulation. Nonetheless, examples of synt... |
42003722 | Tailoring exciplex formation in metal-induced supramolecular organization. | The intramolecular π-polarization induced upon binding the bichromophoric ligand L1 to lanthanide ions produces intermolecular hetero-π-stacked pyrene-terimine organization in the resulting complexes as ascertained by ground state supramolecular aggregations leading to dimeric [L1Ln(hfac)<sub>3</sub>]<sub>2</sub> (Ln =... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.