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42003620 | Modeling Method Based on Traditional Machine Learning and Graph Neural Network for Interpretable Prediction of Short Peptide logD. | Accurate prediction of the octanol/water distribution coefficient (logD) is crucial for evaluating the lipophilicity, ADMET profiles, and potential of drug candidates. With the increasing interest in peptide-based therapeutics, there is a growing demand for reliable logD prediction methods specifically tailored to shor... |
42003539 | Lipid Tail Length Determines Nano-Bio Interactions of Peptide Amphiphile Nanostructures. | Understanding the interactions of nanomaterials with biological systems is essential to designing effective nanomedicines. However, most of our understanding originates from studies with solid nanoparticles, and nano-bio interactions of self-assembled nanomaterials have remained largely unexplored. To address this know... |
42003524 | Unravelling Ice Growth Inhibition by UiO-66 and Its Functionalized Nanoparticles: The Role of Uncoordinated Linkers in Enhancing Interfacial Interactions with Ice. | In organ transplantation, cryogenic storage of live cells is essential, but ice recrystallization during thawing causes cell damage, necessitating effective control strategies. Ice recrystallization inhibition (IRI) agents suppress ice growth through the Gibbs-Thomson effect by binding to the ice surface. Metal-organic... |
42003489 | Therapeutic embolic agents for targeted drug delivery in transcatheter therapies: a review. | Embolization has evolved from a purely mechanical occlusion technique to a multifunctional platform that supports imaging enhancement and therapeutic functions, including localized drug delivery, immunotherapy, and vascular remodeling. Although reviews on embolic agents have been published, the therapeutic performance ... |
42003457 | Mechanistic and electronic structure insights into formate formation in uranium and related actinide complexes. | The stepwise formation of actinide formate complexes provides an important framework for understanding actinide-ligand bonding and reactivity. Density functional theory calculations are used to investigate the thermodynamics, kinetics, and electronic structure of formate formation reactions. On the basis of an establis... |
42003408 | Cyclodextrin-based deep eutectic solvent-constructed chitosan eutectogel for therapeutic delivery of glabridin in diabetic wound management. | Diabetic wounds, characterized by delayed healing and susceptibility to infection, pose a significant clinical challenge. Glabridin (GLD), a natural product, has the potential to promote wound repair, but its application is hindered by poor solubility and low photostability. This study developed a novel adhesive deep e... |
42003407 | Cytosol-Targeting Delivery of Non-Nucleotide STING Agonist Achieves Inhalable Nanoparticle-Based Anthrax Vaccine. | Inhalational anthrax is a deadly disease caused by inhalation of Bacillus anthracis spores. Current anthrax vaccines for human use have limitations including undefined components, limited mucosal immunity, and suboptimal adjuvant delivery. This study introduces 2 polymers, MP1 and MP2, each containing disulfide bonds. ... |
41979221 | G-quadruplexes as therapeutic platforms for anticancer drug delivery: from intrinsic cytotoxicity to drug delivery and nanotechnology. | <h4>Introduction</h4>G-quadruplexes have emerged as a versatile class of oligonucleotides that combine molecular recognition, intrinsic anticancer activity and drug carrier functions, offering new opportunities to improve tumor selectivity and overcome limitations of conventional chemotherapy.<h4>Areas covered</h4>This... |
41811350 | MOF-metal nanohybrid-assisted charge transfer amplification for electrochemical biosensing of the MUC1 cancer biomarker. | Cancer is a severe disease characterized by high mortality and complex pathophysiology; however, its early and accurate diagnosis remains inadequate. Conventional diagnostic approaches often fall short, particularly for dense tissues, and are frequently invasive, costly, and of limited availability. This reinforces the... |
41801229 | Negative selection assisted isolation of a highly selective DNA aptamer for the detection of 17α-ethinylestradiol. | Estrogenic compounds, including both natural estrogens such as estrone (E1) and 17β-estradiol (E2) and synthetic 17α-ethinylestradiol (EE2), are widely recognized for their endocrine-disrupting effects in the environment. EE2 is a key ingredient in oral contraceptives, and it poses environmental challenges due to its r... |
41801140 | Nucleic acid aptamer-functionalized magnetic MIL-53(Al)-NH<sub>2</sub> for highly selective magnetic dispersion solid-phase extraction of chloramphenicol. | Chloramphenicol (CAP), a broad-spectrum antibiotic banned in food animals due to its toxic effects (<i>e.g.</i>, myelosuppression), requires sensitive analytical methods for the detection and monitoring of its residues in food. Herein, an aptamer-functionalized magnetic MOF composite (CAP-Apt@MMIL-53(Al)-NH<sub>2</sub>... |
42030680 | Bioactive microneedles enabled by Ca-MOF-regulated collagenase for synergistic hypertrophic scar remodeling. | Hypertrophic scars resulting from pathological fibrosis and excessive collagen deposition cause significant functional and aesthetic impairment. Conventional therapies often fail to address the underlying molecular mechanisms of collagen overproduction. To overcome these limitations, we developed a novel layered dissol... |
42024984 | Biomimetic Janus supramolecular colloidal motors for bioenergy ATP synthesis and storage. | Precise control of motion is fundamental to living organisms, enabling the execution of complex behaviours. Although previous supramolecular colloidal motors driven by asymmetrically assembled F<sub>O</sub>F<sub>1</sub>-ATP synthase have achieved biomimetic motion, their homogeneous surface properties and random enzyme... |
42019418 | From lab to industry: a critical analysis of β-lactoglobulin nanocarriers for bioactive delivery-bridging molecular design, stimuli-responsive engineering, and scalable manufacturing. | β-Lactoglobulin (β-LG) is a globular whey protein with distinct physicochemical properties: a hydrophobic β-barrel, amphiphilic character, and sensitivity to pH, ionic strength, and heat. These properties enable ligand binding, conformational rearrangement, and self-assembly into nanostructures, making it a promising f... |
42014003 | Alanine modified cellulose nanofibril hydrogel bioadhesives: An injectable angiogenic platform for promoting wound healing. | Injectable hydrogels have gained considerable attention as sutureless bioadhesives for minimally invasive wound closure, owing to their ability to adapt to complex wound geometries. However, upon application, these biomaterials can occupy the wound space, potentially hindering critical healing processes such as angioge... |
42014014 | Synergistic MOF-on-MOF S-scheme heterojunction for highly efficient peroxomonosulfate activation toward tetracycline degradation. | The pursuit of high-performance metal organic framework (MOF) photocatalyst is fundamentally constrained by insufficient charge separation and limited redox capacity. To overcome these challenges, this study constructs a novel S-scheme heterojunction by integrating a conductive Ce MOF with ZIF67 via a facile in-situ gr... |
42013915 | Tumor in-situ self-assembling gold nanorods for photothermally enhanced radiotherapy enabled by multilevel radiosensitization mechanisms. | Radiotherapy is one of the principal modalities for cancer treatment. However, its efficacy is often limited by a complex interplay of various factors, including high level antioxidant in tumor cells, efficient DNA damage repair capabilities, serious tumor tissue fibrosis and consequent hypoxia, etc. Hence, it represen... |
42003102 | Trinity Cooperative Electrode as a High-Performance Electrocatalytic Host for Ultra-Stable, High-Rate Zinc-Halogen Batteries. | Aqueous zinc-halogen batteries (ZHBs) offer safety and low cost but are hindered by halogen dissolution, shuttle effects, and sluggish interfacial kinetics. We present a trinity cooperative electrode (TCE) that integrates a conductive polymer, a supramolecular solvent matrix, and an elastic polymer network to simultane... |
42003025 | Inert Catalytic Sites Unlocked by Micropollutants for Rapid Water Decontamination with Near-Complete Chemical Utilization. | The utilization efficiencies of peroxide and the evolved reactive species are typically low in advanced oxidation processes due to their self-quenching or scavenging by background factors in water matrices. Here, we design a new Co-based metal-organic framework (PKU-24) with a six-coordinate structure that induces stro... |
42002938 | Unsymmetric Heptamethine Cyanines as a General Strategy to Construct Nonaggregating Fluorophores for Biomedical Imaging. | Heptamethine cyanine dyes are widely used as near-infrared (NIR) fluorophores in biomedical imaging. However, conventional heptamethine cyanine fluorophores are symmetric in nature, which favors fluorophore self-assembly from π-π stacking in aqueous media. This H-aggregation significantly reduces the fluorescence inten... |
42001429 | Detergent Conjugation Decouples Chlorpromazine Solubility from Antibacterial Activity against Bacteria Relevant for Gut Microbiota. | The water solubility of hydrophobic amine drugs is pivotal for oral bioavailability and routinely secured by hydrochloride salt formation. In the case of the antipsychotic chlorpromazine, this approach yields a cationic amphiphile with antibacterial potency, which correlates with alterations in gut microbiota. It remai... |
42001355 | Plant-derived extracellular vesicles as a promising therapeutic and drug delivery strategy for tumor oxidative stress and inflammation. | Oxidative stress and chronic inflammation are key factors in tumor progression. Existing antioxidant and anti-inflammatory treatment methods are limited due to their specificity, bioavailability and impact on non-target sites. Plant-derived extracellular vesicles (PDEVs), as an innovative category of natural nanocarrie... |
42001298 | How to Use Quantum Computers for Biomolecular Free Energies. | Free energy calculations are at the heart of physics-based analyses of biochemical processes. They allow us to quantify molecular recognition mechanisms, which determine a wide range of biological phenomena, from how cells send and receive signals to how pharmaceutical compounds can be used to treat diseases. Quantitat... |
42026453 | Engineered with tannic acid-magnesium metal-phenolic frameworks: A multifunctional 3D-printed PCL/TCP scaffold for bone regeneration. | Critical-sized bone defects, typically resulting from trauma, infection, or tumor resection, pose a substantial clinical challenge. Traditional bone grafting methods, including autografts and allografts, face constraints due to donor scarcity, surgical morbidity, immune rejection, and infection risks. Bone tissue engin... |
42025046 | MOF nanosheets with topology enhanced ultrahigh relaxivity. | Two-dimensional (2D) metal-organic framework (MOF) nanosheets have emerged as a promising class of functional materials. Nevertheless, the fabrication of MOF nanosheets with well-defined uniformity and ultrathin thickness via traditional synthetic strategies still remains a great challenge. Herein, we report that ultra... |
42013577 | Covalently functionalized MoS<sub>2</sub> nanopore with amino acids for label-free protein residue discrimination. | Precise detection of amino acids is critical for proteomics and molecular recognition. Nanopore sensing enables label-free single-molecule analysis but often lacks sufficient spatial resolution to control translocation dynamics and resolve protein structure function relationships. Here, we employ all-atom Molecular Dyn... |
42009287 | Zearalenone-14-glucoside forms a self-assembled supramolecular gel with enhanced toxicity through cytochrome P450 depletion. | Zearalenone-14-glucoside (Z14G) is a widely contaminating modified mycotoxin in the global food and feed. For the first time, we report that Z14G formed a self-assembled supramolecular gel. Results from our morphological and chemical characterizations, rheological testing, and molecular simulation dynamics demonstrated... |
42009248 | Dual Immune Lineage Activation Underlies Systemic Immunopathology in ACLF. | Acute-on-chronic liver failure (ACLF) is a rapidly progressive syndrome characterized by acute hepatic decompensation in the setting of chronic liver disease (CLD), and frequently accompanied by multi-organ dysfunction/failure (MOF) and high short-term mortality. Although a dysregulated immunity(immunopathology) is inc... |
42009223 | Lipidized deferoxamine nanomedicines (DFOsomes) against iron overload. | Secondary iron overload disorders demand effective strategies for removing excess iron, yet conventional chelators such as deferoxamine (DFO) are limited by poor pharmacokinetics, low bioavailability, and dose-dependent toxicities. Here we introduce DFOsomes, a first reported lipidized DFO nanomedicine. Developed throu... |
42009185 | Driving efficient adsorption photocatalytic synergistic degradation of Cr(VI) and rhodamine B based on MIL-125-NH<sub>2</sub>(Ti) heterojunction under visible light. | A MIL-125-NH<sub>2</sub>/Fe-g-C<sub>3</sub>N<sub>4</sub> heterojunction photocatalyst was successfully synthesized via a hydrothermal method, and comprehensive characterization of its crystal structure, morphology, optical properties, and electronic structure analysis confirmed the successful construction of the hetero... |
42004897 | Whole Genome Sequencing Reveals High Prevalence of Antimicrobial Resistance Genes in <i>Salmonella</i> Isolates From Diarrheal Patients in Jinan, China. | <h4>Background</h4>The global emergence of multidrug-resistant (MDR) <i>Salmonella enterica</i> poses a significant public health threat, particularly in developing countries where antibiotic consumption remains high. However, genomic data on circulating <i>Salmonella</i> strains in Eastern China remain limited.<h4>Obj... |
41999305 | An Aqueous-Phased Synthesized CoMo-LDH Nanocage Activates Peroxymonosulfate for Tetracycline Degradation. | Tetracycline (TC) is a widely used antibiotic and agricultural additive, which persists in aquatic environments and poses ecological risks. Peroxymonosulfate (PMS)-based advanced oxidation processes (AOPs) provide promising solutions for the transformation of TC, but they require efficient catalysts. Here, we synthesiz... |
41999301 | Integrated Microfluidic SERS Sensor Featuring Au NPs@Cu MOF/Hydrogel for Label-Free and Specific Creatinine Detection. | Creatinine is a critical biomarker for assessing renal function, and its accurate detection is essential for early diagnosis of kidney diseases. However, real-time and label-free specificity creatinine sensing remains challenging. Herein, we present an integrated microfluidic surface-enhanced Raman scattering (SERS) pl... |
41999261 | Spin-State Engineering of Ni Centers by Dual-Ligand Competitive Coordination for Superior Oxygen Evolution Reaction. | Modulating electronic spin states of metal active centers is an effective strategy to address the sluggish oxygen evolution reaction (OER) kinetics. Herein, we utilize a dual-ligand competitive coordination strategy to induce lattice expansion, generate abundant oxygen vacancies and unsaturated coordination sites, and ... |
42001201 | Eco-evolutionary dynamics of a shifting porcine parvoviruses (PPV1-PPV8) ecosystem reveal dichotomous selection pressures. | Porcine parvoviruses (PPVs) constitute a complex viral ecosystem. However, the genetic structure and evolutionary dynamics of currently circulating PPV populations remain poorly characterized. A large-scale genomic survey in China (1,055 genomes; 863 samples; 2021-2024) reveal a profound ecosystem shift, with PPVs dete... |
42001054 | Turmeric-derived exosome-coated ZIF-8 nanoplatform for targeted delivery of TGF-β1 siRNA in the treatment of liver fibrosis. | Liver fibrosis constitutes a progressive pathological condition for which TGF-β1 pathway-targeted siRNA therapy holds considerable therapeutic potential. Nevertheless, clinical application of TGF-β1 siRNA is critically limited by inherent instability and inefficient delivery in vivo. In this study, we engineered an inn... |
42000888 | Advancing protein engineering via organic chemistry. | Proteins are central to nearly all biological processes; their functions are tightly regulated by dynamic mechanisms such as covalent alterations; e.g., post-translational modifications (PTMs). These modifications can influence the protein's structure, localization, and activity. Inspired by this diversity and regulati... |
42000750 | Enhancing gas sensing recyclability and recovery rate by crystal engineering of CuI motif in MOFs. | Metal-organic frameworks (MOFs) possess high sensitivity as chemiresistive gas sensing materials at room temperature (RT), while their applications are severely hampered by the issues of slow recovery and poor recyclability. To address these challenges, a strategy integrating DFT calculation with experimental synthesis... |
41999323 | Regulating C-C Coupling via CO Generation and Utilization in CO<sub>2</sub>RR on Ag-Cu Catalysts. | Ag-Cu tandem catalysis provides an effective strategy to enhance C<sub>2+</sub> selectivity in the electrochemical CO<sub>2</sub> reduction reaction (CO<sub>2</sub>RR) by integrating CO generation and utilization for C-C coupling. Here, we report a series of Ag@Cu<sub>2</sub>O, Ag@CuO, and Ag@CuO-BDC core-shell catalys... |
41999319 | Thermally Induced Macromolecular Sequence Inversion in Triblock Copolymers and Terpolymers. | Dynamic control over polymer sequences remains a major challenge in synthetic macromolecules, limiting their adaptability relative to biomacromolecules. Herein, we introduce an intra-macromolecular sequence inversion in triblock copolymers and terpolymers using a furan-maleimide-anthracene Diels-Alder system, enabling ... |
41999315 | Conformation-Adaptive Crown Ether-Polyimides as Superfast and Exceptionally Selective Artificial Na<sup>+</sup> Channels. | The development of artificial Na<sup>+</sup> channels that simultaneously achieve high permeability and high selectivity remains a formidable challenge, as existing systems are constrained by a limited performance ceiling. To address the classical permeability-selectivity trade-off, we present an adaptive design strate... |
42034928 | A bioelectrochemical aptamer sensor using vanadium-porphyrinic metal-organic framework for noninvasive hydrocortisone monitoring in sweat. | Hydrocortisone (HC) is a vital steroid hormone secreted by the adrenal cortex that regulates how the body responds to stress, the immune system and metabolism. The primary objective of this study is the fabrication of an electrochemical aptamer sensor founded on a vanadium-porphyrin metal-organic framework (V-PMOF) to ... |
42033988 | Defect-engineered metal-organic framework as a universal platform for theranostic applications. | Rational design of nanocarriers as specific multidrug co-delivery systems to overcome the complex disease microenvironment still remains a critical challenge in precision nanomedicine. In this study, using dicarboxyl-functionalized indocyanine green (Bis-COOH-ICG) as an auxiliary ligand coordinated with Zr<sub>6</sub> ... |
42030654 | Evaluation of chromatographic resins for high efficacy separation of radium from chemical analogues. | The separation of Radium (Ra) from interfering chemical analogues is of major importance for both the accurate measurement of Ra-226 in environmental samples and the preparation of radium targets destined for medical isotope production. The adsorption behavior of Ra, Barium (Ba), and Strontium (Sr) was investigated on ... |
42019305 | Heterolinker MOFs synergized with entropy-driven DNA amplification for precision dual-mode sensing of Microcystin-LR. | To overcome the high risk of false results in single-mode detection for environmental toxins, a self-validating dual-mode biosensing platform integrating photoelectrochemical (PEC) and fluorescence (FL) signals was developed for the ultrasensitive detection of Microcystin-LR (MC-LR). The sensor of core innovation lies ... |
42013742 | A dual-emission tb-MOF-based Ratiometric fluorescent probe for multiplexed detection and discrimination of antibiotics with a smartphone-assisted portable platform. | The development of sensitive and selective sensing platforms for monitoring antibiotic residues is crucial for environmental protection and public health. Herein, a highly luminescent terbium-based metal-organic framework (Tb-MOF) was synthesized using a dual-ligand strategy with 1,4-benzenedicarboxylic acid (H₂bdc) an... |
42013671 | One-pot pyrene-functionalized UiO-66-NH<sub>2</sub> enables pH-Gated speciation of serum copper: Exchangeable versus total copper. | Metal ion dysregulation, particularly involving copper, has been implicated in neuropsychiatric disorders including depression. Herein, we report a pyrene-functionalized UiO-66 platform (UiO-66-NH-PCA) prepared by a facile one-pot solvothermal strategy that avoids complicated pyrene-ligand presynthesis and tedious post... |
42011223 | Article Watch. | This column highlights recently published articles that are of interest to the readership of this publication. We encourage ABRF members to forward information on articles they feel are important and useful to Clive Slaughter, AU-UGA Medical Partnership, 1425 Prince Avenue, Athens GA 30606. Tel; (706) 713-2216: Fax; (7... |
42008909 | Multifunctional boronic acid-modified zirconium-based MOFs as peroxidase-mimicking colorimetric platforms for β-NAD capture and detection. | Metal-organic frameworks (MOFs) offer tunable porosity, large surface area, and versatile surface chemistry, making them promising candidates for multifunctional nanoplatforms. Here, we report the functionalization of zirconium based MOFs (UiO-66-NH<sub>2</sub>) with 4-formylphenylboronic acid (FPBA) to integrate cis-d... |
42006827 | Fluorine-engineered two-dimensional covalent organic frameworks for enhanced C<sub>2</sub>H<sub>2</sub>/CO<sub>2</sub> separation. | Efficient separation of C<sub>2</sub>H<sub>2</sub> from CO<sub>2</sub> remains a significant challenge owing to their closely matched molecular dimensions and physicochemical properties. Developing adsorbents capable of discriminating between these two gases is therefore of considerable importance for acetylene purific... |
42006821 | Photophysical studies of diazines: effects of solvents and complexation with Cu<sup>2+</sup>, Ni<sup>2+</sup>, Co<sup>2+</sup> and Pb<sup>2+</sup> ions. | The detection of toxic metal ions, such as Pb<sup>2+</sup>, has become important because they cause several health issues. This study describes the photophysical properties displayed by a few symmetrical diazine compounds and the influence of solvent polarity on their emission spectra. It is noted that <i>λ</i> <sub>em... |
42006819 | pH-responsive Ni-MOF based nanocarriers with folic acid targeting for enhanced chemotherapeutic efficacy in breast cancer. | Breast cancer is among the most prevalent malignancies affecting women globally. Conventional chemotherapeutic treatments like 5-fluorouracil (5-FU) are not very effective and can cause serious side effects. To address these challenges, we developed a folic acid-functionalized nickel-based metal-organic framework incor... |
42006816 | Spectro-kinetic modelling of photocatalytic oxidation of heterocyclic compounds in a continuous-flow packed bed reactor. | Mechanistically derived predictive kinetic models for photocatalytic processes have inherent challenges due to short lived charge carriers and free radical intermediate species. In this work, we present a spectro-kinetic model for the photocatalytic oxidation of carbazole (CAB), a nitrogen-containing heterocyclic compo... |
42006813 | Synthesis, characterization, <i>in vitro</i> and computational assessment of new xanthene hydrazone derivatives as promising vasorelaxant agents. | Functionalized xanthene hydrazone derivatives were synthesized using two distinct pathways. Two routes of synthesis, involving condensation and <i>O</i>-alkylation reactions, were adopted to synthesize the target compounds. The structures of the synthetised intermediates and xanthene hydrazone derivatives were confirme... |
42006802 | Mechanistic perspectives on antimalarial agents: from FDA-approved drugs to next-generation candidates. | Malaria is a major global health challenge, demanding continued innovation in drug discovery and development. This review gives a comprehensive overview of FDA-approved antimalarial drugs and emerging clinical candidates, focusing their chemical structures, mechanisms of action, and molecular targets such as PfATP4, DH... |
42006798 | Frontiers in manganese catalysis: a sustainable platform for bond construction and heterocycle synthesis. | The progress of earth-abundant transition metal-based catalytic methodologies has driven growing interest within the scientific community for the construction of bioactive organic molecules. Among the earth-abundant transition metals, manganese is an attractive alternative to precious metals in synthetic methodologies ... |
42006583 | Dysregulation of Extracellular Vesicle Concentration, MicroRNAs, and Surface Proteins in Patients With Niemann-Pick Disease Type C. | Niemann-Pick disease type C (NPC) is a rare neurodegenerative disease primarily caused by mutations in the <i>NPC1</i> gene, which is associated with cholesterol trafficking impairment, and disruption of endolysosomal processing and extracellular vesicles (EVs). Here, for patients with <i>NPC1</i> mutations (NPC) and a... |
42006584 | Multifunctional Electrospun Phase Change Material Mats for Solar-Thermal Energy Storage and Photothermal Conversion. | Efficient solar-thermal energy conversion and storage demand materials that combine high latent heat with multifunctional performance were observed. Here, we report electrospun polyester-based phase change material (PCM) mats capable of simultaneous thermal energy storage and photothermal conversion. Among a series of ... |
42006479 | A fingerprint-based polymeric sensing platform for comprehensive quality assessment of complex culture media in cell manufacturing. | The rapid advancement of cell manufacturing across biotechnology, regenerative medicine, and cellular agriculture is driving a growing demand for simple and reliable analytical tools to ensure the consistent quality of complex culture media, whether derived from natural or synthetic sources. Here, we present a hypothes... |
42006462 | Correction: Recent advances in MOF-based single-atom photocatalysts for CO<sub>2</sub> to solar fuel conversion under sunlight irradiation. | [This corrects the article DOI: 10.1039/D6SC00691D.]. |
42005985 | Modernising antiviral drug discovery: harnessing medicinal plants through machine learning and metabolomics to target the SARS-CoV-2 main protease. | The COVID-19 pandemic highlighted critical limitations in the speed, scalability and translational efficiency of conventional antiviral drug discovery. Although vaccines and repurposed antivirals have reduced disease severity, the continued emergence of SARS-CoV-2 variants and breakthrough infections underscores the ne... |
42005330 | Phytochemistry and Bioactivities of Thymol and Carvacrol: Molecular Pathways, Metabolism, and Therapeutic Insights. | The concept of "One Health" has developed an inimitable bond between humans and plants, and from the dawn of humankind, plants have been consumed for both food and medicine. The use of plant-based products has increased due to their health-promoting potential, owing to nutritional composition and rich phytochemistry. T... |
42005326 | Nutritional Intervention With Perennial Ryegrass Modulates UA Metabolism in Goslings via Gut Microbiota-Antioxidant Pathway Modulation. | Hyperuricemia (HUA) is a metabolic disorder characterized by excessive uric acid (UA) accumulation resulting from increased hepatic production and impaired renal and intestinal excretion. Nutritional interventions using plant-based feed resources rich in bioactive compounds have shown promise in regulating urate metabo... |
42004942 | Antimicrobial nanomaterials at the nanoscale: design principles, mechanisms, and global challenges. | The rapid escalation of antimicrobial resistance (AMR) represents a major global health challenge, undermining the clinical efficacy of conventional antibiotics and driving the demand for alternative therapeutic strategies. Advances in nanoscience have positioned nanoscale materials as a powerful platform for the devel... |
42004941 | A BiVO<sub>4</sub>/UU-200 heterojunction for efficient visible-light photocatalytic degradation of rhodamine B. | Heterostructured photocatalysts are widely recognized for enhancing charge separation; however, their performance under visible-light irradiation remains limited by inefficient interfacial charge transfer. In this study, BiVO<sub>4</sub>/UU-200 heterostructured photocatalysts were successfully synthesized <i>via</i> a ... |
42004809 | CAR-T Cells: Current Status, Challenges, and Future Prospects. | As chimeric antigen receptor (CAR)-T cell therapy has expanded rapidly to meet the growing global cancer burden; many challenges have emerged as a critical factor influencing its efficacy. However, due to the complicated mechanisms of CAR-T cells, human interference alone was insufficient to optimize the outcomes. In p... |
42001691 | Green and efficient ultrasound-assisted supramolecular solvent extraction of Plantago asiatica L.: Process optimization, mechanism, and hypouricemic efficacy. | Plantago asiatica L. (PA), a traditional Chinese medicinal and edible plant, is rich in the hypouricemic bioactive components plantamajoside (PMS) and acteoside (ACT). This study pioneers the development of an efficient and environmentally friendly ultrasonic-assisted supramolecular solvent extraction (SUPRAS-UAE) meth... |
41998751 | Thlaspi arvense attenuates colitis-associated colorectal tumorigenesis through suppression of neutrophil recruitment via the NOD/NF-κB pathway. | <h4>Background</h4>In colitis-associated colorectal cancer (CAC), chronic inflammation is the primary driver of tumorigenesis. A critical event in this process is the massive recruitment of neutrophils, which, while part of the host defense, can paradoxically fuel cancer progression. Excessive neutrophil infiltration c... |
41998691 | From acute responses to long-term monitoring: a scoping review of the reliability and validity of biomechanical and physiological assessment tools in elite and highly trained swimmers. | <h4>Background</h4>Scientific monitoring is fundamental to optimizing swimming performance, but its effectiveness relies on the validity and reliability of assessment tools.<h4>Objective</h4>Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR), this... |
41998635 | 18-β-glycyrrhetinic acid facilitates nuclear-mitochondrial communications to alleviate oxidative stress through HMGB1-cGAS-Mul1 axis in tendinopathy. | <h4>Background</h4>Tendinopathy is a prevalent orthopaedic condition characterized by disrupted tendon homeostasis, with oxidative stress being a key contributing mechanism. Although the natural compound 18-β-Glycyrrhetinic acid (GA) exhibits antioxidant properties and is a therapeutic candidate for tendinopathy, its p... |
41998270 | Space filling shapes the interaction networks in mixed pyrrole-benzene trimers and tetramers. | The structural preferences of molecular assemblies are governed by a delicate balance between strong directional forces and diffuse dispersion contacts. Mixed trimers of pyrrole (Py) and benzene (Bz) provide an ideal benchmark to probe this interplay: the robust N-H⋯π interaction anchoring the Py-Bz dimer competes with... |
41997979 | Coupling uranyl upcycling with photoelectrochemical urea degradation for radioactive organic wastewater management. | Radioactive organic wastewater management concerning metal source recovery and organic matter degradation conforms well to the notion of circular economy and environmental protection, but the concurrent conversion in an integrated process is challenging and has been rarely studied. Here, we introduce a high-performance... |
41997952 | Supramolecular recognition on the surface of two-dimensional polyketones. | Two-dimensional polymers constitute an emerging class of materials with structurally defined, atomically thin architectures that impart unique optical, electronic, and host-guest properties. Here, we report the synthesis of a crystalline two-dimensional polyketone (2D-PK) via a Friedel-Crafts acylation reaction at a so... |
41997926 | Arrested coalescence in structured liquids. | Structuring liquids can be achieved by the assembly and jamming of particles at the oil-water interface. However, this typically requires surface modification of particles or co-assembly with polymer ligands to enhance interfacial binding energies. Here, we show a simple and robust strategy to structure liquids by usin... |
41997910 | NIR-II-triggered plasmonic catalysis with tip-localized enhancement: a strategy for hypoxic biofilm eradication on orthopedic implants. | The utilization of light as an external stimulus to promote the generation of hot electrons in plasmonic heterostructures and thus augment their catalytic efficacy presents significant potential for bacterial biofilm eradication. However, the inefficient harnessing of photoinduced hot electrons in conventional develope... |
41997881 | Tailoring a Polyoxometalate-Based Metal-Organic Framework for Photocatalytic Oxidative Cross-Coupling Reactions to Synthesize Benzo(naphtho)thiazoles. | Benzo(naphtho)thiazoles and their derivatives are widely used in optoelectronic materials, medicinal chemistry, and industry. Visible-light-induced photocatalytic cross-dehydrogenative coupling (CDC) reactions have emerged as a green and efficient alternative, but existing catalytic systems still suffer from limitation... |
41997714 | Quantum Dot-Phage Nanoarchitectonics for Targeted Synergistic Therapy of Methicillin-Resistant <i>Staphylococcus aureus</i> Wound Infections. | Chronic wound infections caused by methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) often refractory to conventional therapies due to bacterial drug resistance and biofilm formation. To address this challenge, we developed a synergistic antibacterial nanoarchitectonics integrating bacteriophages and quantum do... |
41997706 | Cost-effectiveness of osteoporotic fracture risk assessment in people with intellectual disabilities: a UK NHS modelling study. | <h4>Objectives</h4>We compared the cost-effectiveness of alternative fracture risk assessment strategies for people with intellectual disabilities (ID) aged ≥40 years from a UK National Health Services perspective over a lifetime horizon.<h4>Design</h4>Cost-effectiveness analysis using a lifetime decision-analytical mo... |
41997621 | Regulating Layer Organization to Engage Amino Groups for Efficient CH<sub>4</sub>/N<sub>2</sub> Separation in a Pillar-Layer Metal-Organic Framework. | Selective capture of methane (CH<sub>4</sub>) from nitrogen (N<sub>2</sub>) in coal-bed methane using a physisorbent represents a promising strategy due to its potential for low energy consumption and cost-efficiency. Microporous metal-organic frameworks (MOFs) offer considerable potential for this application through ... |
41996705 | Carbon-Encapsulated Silicon@Co<sub>0.85</sub>Se Anode for High-Performance Lithium-Ion Batteries. | Silicon (Si) anodes exhibit remarkable theoretical capacity, enabling them to be attractive candidates for high-energy-density lithium-ion batteries. However, conventional surface-modification strategies on Si often fail due to insufficient adhesion between the coating and Si, thereby giving rise to interfacial degrada... |
41996702 | Probing Bowl-to-Bowl Inversion in Enantiopure Subphthalocyanines: Cofacial S<sub>N</sub>2 vs S<sub>N</sub>1 Pathways at a Tetracoordinate Boron Center. | Understanding the bowl-to-bowl (<i>BtB</i>) inversion of bowl-shaped π-systems is essential to fully harnessing their topology in chiral molecular materials. In boron subphthalocyanines (SubPcs)─contracted porphyrinoids known for their high functional versatility─this conformational flexibility is locked by the tetrahe... |
41996663 | Film, function, flexibility: label-free nanobody sensors <i>via</i> electropolymerized nanointerfaces. | Nanobody-based biosensors promise exceptional molecular recognition and robustness, but their implementation has been limited by unstable and non-scalable surface chemistries. Here we introduce a materials platform that integrates stable electropolymerized tyramine nanofilms with label-free, non-faradaic electrochemica... |
41996630 | Temperature-Dependent Supramolecular Assemblies in Surfactant-Biopolymer Systems: Thermodynamic, Acoustic, and Computational Insights. | We report a systematic investigation of temperature-dependent supramolecular assemblies and micellar behavior in aqueous sodium dodecyl sulfate (SDS) solutions in the presence of <i>Aloe vera</i> gel (AVG; 1%, 2%, and 5% w/v) as a biopolymeric modulator. Acoustic, thermodynamic, and physicochemical measurements, includ... |
41996591 | Simultaneous Localization of Electrons/Holes by Surface Cationic Dangling-Bonds/Vacancies for Synergistically Boosting Photocatalytic Activity. | Simultaneous localization of photoelectrons and holes into different surface defects on a single-component photocatalyst is an ideal strategy for maximizing photocatalytic activity yet remains a huge challenge. We propose a novel concept of creating two distinct defects, cationic dangling bonds and vacancies, on the su... |
41996504 | Multifunctional ionic thermoelectric elastomer enhanced by Le Chatlier principle in synergistic supramolecular hydrogen bonding system. | When quasi-solid-state ionic thermoelectric (i-TE) devices transition from ideal laboratory testing platforms to real-world wearable applications, the main challenge shifts from electrochemical conversion efficiency to the adaptability of physical application scenarios. This study is based on a dynamic supramolecular h... |
41996497 | Macrocycle-based covalent organic networks for ultrafast sub-1-Å precision ion sieving. | The water-energy nexus demands membranes with subångström ion-sieving precision, a capability hindered by the intrinsic selectivity limits of conventional materials. We fabricated ultrathin covalent organic network (CON) membranes via interfacial polymerization of 1,4,7,10-tetraazacyclododecane (cyclen) with either ter... |
41996494 | Healthy donor T cell receptors expand functional neoantigen recognition beyond patient vaccination. | A major challenge in advancing neoantigen-targeted therapies lies in the limited capacity of predicted neoantigens to robustly activate CD8<sup>+</sup> T cells, emphasizing the critical need for comprehensive functional validation before patient vaccination. Here, we provide a direct comparison of neoantigen-specific T... |
41996304 | Multiomics profiling of zebrafish embryonic cell line PAC2 across growth phases to assess its relevance for toxicological studies. | Permanent fish cell lines offer promising alternatives to traditional animal models for environmental risk assessment of chemicals. However, to facilitate broader uptake into toxicity testing practice, a better understanding of functional capacities and expression of toxicologically relevant molecular targets is needed... |
41996288 | Tailoring inter-core distance of clustered SPIONs using silica spacers for enhanced magnetic particle imaging (MPI). | An emulsion-based self-assembly strategy for the formation of Superparamagnetic Iron Oxide Nanoparticles (SPION) clusters with precisely tunable silica spacers is reported. Systematic control of the silica shell thickness enables modulation of magnetic inter-core spacing within the clusters. This results in a pronounce... |
41996284 | Single Ni Atoms Drive Carboxyl Deprotonation in Metal-Organic Chains. | Understanding how charge transfer and ligand activation processes govern metal-organic coordination at surfaces is crucial for controlling on-surface synthesis and the formation of low-dimensional architectures. Here, we show that Ni promotes the deprotonation of the carboxyl groups of terephthalic acid (TPA) on Ag(100... |
41996079 | The Influence of the Co/Cu Ratio and Organic Ligand in MOF/ Copper Phthalocyanine-Derived Tandem Electrocatalysts on the Electrocatalytic Nitrate Reduction Reaction. | Electrocatalytic nitrate reduction reaction (NO<sub>3</sub>RR) offers a sustainable pathway for ammonia production, yet it remains challenging to achieve high activity and high selectivity within a single catalytic system. Herein, we construct a series of MOF-derived Cu<sub>x</sub>Co<sub>y</sub>-based catalysts, among ... |
41995990 | Downregulation of miRNAs Accompanies Increased HERV-K (HML-2) Expression in Amyotrophic Lateral Sclerosis. | Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease with limited treatments. Evidence suggests that reactivation of the HERV-K (HML-2) subgroup contributes to its pathogenesis. This study explores the role of microRNAs (miRNAs) in regulating HML-2 expression. We identified dysregulate... |
41995791 | Polycationic dendrimers synergizes with gefitinib to overcome EGFR<sup>Ex19Del</sup>-driven resistance in non-small-cell lung cancer. | Lung cancer is a heterogeneous disease and the leading cause of cancer-related deaths worldwide. The aggressiveness of non-small-cell lung cancer (NSCLC) is often associated with oncogenic activation of the mitogen-activated protein kinase (MAPK) pathway. Among the most prevalent mutations in NSCLC, epidermal growth fa... |
41995609 | Host-Guest Interaction-Instructed In Situ Self-Assembly of Therapeutic Peptides for Enhancing Antitumor Efficacy. | Therapeutic peptides have played a huge role in chemotherapy due to their excellent biological activity and biocompatibility. However, therapeutic peptides are vulnerable to enzymatic digestion, which makes them with fast elimination in vivo. Nowadays, peptides self-assembly has become a powerful strategy for construct... |
41995448 | Ultra-sensitive mercury sensor based on thin film transistor using flavin self-assembly on monochiral carbon nanotubes. | Achieving ultra-sensitive mercury detection requires precise molecular design and seamless integration with electronic sensing systems. Here, we show that a monochiral single-walled carbon nanotube (SWCNT) thin-film transistor (TFT) sensor, helically wrapped with flavin molecules, achieves remarkable sensitivity to mer... |
41995443 | Cationic Polymer-Photothermal Agent Conjugates with Enhanced Light Absorption and Tumor Accumulation for Efficient Phototherapy of Osteosarcoma. | The development of nanoanticancer agents has garnered significant interest, particularly for their application in the second near-infrared (NIR-II) phototherapy. Despite the promise that nanoparticles hold for tumor phototherapy, their limited light absorption efficiency and tumor accumulation ability substantially con... |
41995430 | Late-stage peptide nitroarylation: stereoelectronic tuning and molecular recognition. | Aromatic amino acids lie at the center of protein folding and interactions. For the three aromatic amino acids commonly found in proteins - phenylalanine (Phe), tyrosine (Tyr), and tryptophan (Trp) - their large size and hydrophobic character, as well as electrostatic interactions involving their π systems, provide sub... |
41995398 | Competitive supramolecular assembly tunes anthracene emission over 165 nm <i>via</i> controlled π-overlap. | Competition among hydrogen-bonding and B ← N coordination in <i>p</i>-nitrophenylboronic acid/9,10-bis(pyridin-4-ylethynyl)anthracene assemblies yields five crystalline phases, where tunable anthracene π-overlap (0-64.5%) controls solid-state emission (569-734 nm) and defines a direct structure-property relationship. |
41995375 | W<sub>2</sub>N<sub>3</sub> nanodot/2D C<sub>3</sub>N<sub>4</sub> heterostructures with interfacial covalent bonding toward Pt-free photocatalytic hydrogen evolution. | Graphitic carbon nitride is a promising photocatalyst for hydrogen evolution, but its performance is severely limited by rapid carrier recombination and the reliance on noble-metal (<i>e.g.</i>, Pt) cocatalysts. To address this challenge, we develop a supramolecular assembly strategy enabling <i>in situ</i> growth of u... |
41995357 | Light and Enzymatic Cooperative Response in Supramolecular Fibers: A Synergistic Strategy for Potential Drug Delivery Applications. | Supramolecular Polymers (SPs) can undergo reversible self-assembly in response to internal or external stimuli. Design strategies based on the benzene-1,3,5-tricarboxamide (BTA) core are gaining increasing attention. In this study, we describe a BTA amphiphile that self-assembles into supramolecular fibers in water and... |
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