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41995218 | Rapid ambient direct growth of HKUST-1 <i>via</i> atmospheric pressure plasma treatment. | The integration of metal-organic framework (MOF) thin films into functional devices is currently hindered by high temperatures, prolonged processing times, and complex additives required by conventional fabrication methods. We demonstrated a plasma-assisted strategy to directly synthesize crystalline MOF films on metal... |
41995202 | Breaking the bottlenecks in nanozyme-antibody conjugate preparation: challenges, optimization strategies, and applications of <i>in vitro</i> diagnostics. | Enzyme-labeled antibodies serve as the fundamental pillars of immunoassay-based biosensing, providing the necessary molecular recognition and signal amplification for the detection of trace analytes in complex matrices. As robust mimics of natural enzymes, nanozyme-antibody conjugates (NACs) represent a significant adv... |
41995194 | Synergic cancer chemo-immunotherapy comprising combined doxorubicin and siRNA targeting CD47 co-delivered by a bola-amphiphilic dendrimer. | Restoring antitumor immunity while enhancing the chemotherapy efficacy represents an optimistic strategy for cancer treatment. Enabling macrophage-mediated phagocytosis of cancer cells is pivotal for rehabilitating effective immune responses. However, its efficacy is often limited by elevated anti-phagocytic signals, s... |
41995174 | The effects of external electric fields on proteins. | Proteins are highly abundant and, as a biomolecular class, have very versatile functions in living systems. Protein structures contain electrically charged residues and proteins' electrostatics are crucial for their function. Although protein activity is commonly modulated through a variety of ligands and post-translat... |
41995147 | <i>Aloe vera</i> and <i>Sterculia</i> gum-based hydrogel for use in drug delivery and dressing applications to improve wound healing. | Recently, significant advancements have been made to develop functional materials from bioactive polysaccharides for use in healthcare products and biomedical applications. <i>Aloe vera</i> (AV) and <i>Sterculia</i> gum (SG) polysaccharides exhibit inherent antioxidant, anti-inflammatory, and anti-microbial activities.... |
41995122 | Bioinspired Interfacial Hydration Engineering via Metal-Organic Frameworks for Efficient Nitrate-To-Ammonia Conversion in Neutral Media. | Electrocatalytic nitrate reduction to ammonia (eNO<sub>3</sub>RR) offers a promising pathway for sustainable ammonia synthesis but is severely impeded by sluggish proton-coupled electron transfer kinetics and competitive hydrogen evolution, particularly at industrially relevant current densities in neutral media. Herei... |
41995112 | Recent Advances in Zirconium-Based Metal-Organic Framework Membranes for Desalination. | Zirconium-based metal-organic frameworks (Zr-MOFs) have emerged as promising desalination membrane materials owing to their exceptional chemical and hydrothermal stability, tunable nanoporous architectures, and versatile surface functionality. This review summarizes recent advances in Zr-MOF membranes for desalination,... |
41995100 | A porous van der Waals single-crystal of aromatic dendrimer exhibiting enhanced thermally activated delayed fluorescence. | Here we report the single crystal structure and enhanced thermally activated delayed fluorescence (TADF) properties of a porous van der Waals crystals of G3TAZ, a 3rd-generation aromatic dendrimer composed of a triazine core (TAZ) and carbazole (Cz) dendrons. Single-crystal structural analysis by electron diffraction r... |
41995038 | Carbon-layer-encapsulated MOF-derived CoS<sub>2</sub> for enhanced sodium-ion storage. | Transition metal sulfides have emerged as promising anode materials for sodium-ion batteries (SIBs) owing to their high theoretical capacities. However, their practical application is hindered by rapid capacity degradation, primarily attributed to polysulfide shuttling and structural collapse. In this study, we present... |
41994993 | Design and Synthesis of a Pt Single-Atom-Decorated g-C<sub>3</sub>N<sub>4</sub>/2D Porphyrinic MOF Composite for Photocatalytic Nitrobenzene Hydrogenation. | Reduction of nitroarenes via photocatalysis is a promising strategy for the sustainable production of anilines. Catalytic systems featuring type-II heterojunctions are widely considered effective for photocatalytic reactions due to their well-defined interfacial charge transfer mechanism. Herein, a type-II heterojuncti... |
41994951 | Ultrastable Heterocluster Metal-Organic Framework Scintillator via Reticular Armoring of Iodocuprate Modules for X-ray Imaging. | Metal-organic framework (MOF)-based scintillators promise advanced X-ray detection and imaging by virtue of their structural tunability. However, the simultaneous attainment of high radioluminescence efficiency, ultralow detection limits, and extreme environmental robustness remains a formidable challenge. Herein, we r... |
41994944 | Conversion Between 2- and 3-Dimensional Halogen-Bonded Networks Formed From a Single N-Oxide/Iodoalkyne Building Block. | Despite their promise as porous supramolecular materials, permanently porous halogen-bonded frameworks have not been realized, and progress in the field is limited by a lack of understanding of what happens when these materials are activated via solvent exchange or under vacuum. In the current work, a single building b... |
41994952 | Triangulation of Guest Species in Porous Frameworks Using Solid-State NMR Spectroscopy and Quantum Chemical Calculations. | Porous functional materials, such as zeolites and metal-organic frameworks (MOFs), are invaluable to chemical industries due to their high surface areas and chemical versatility. Understanding how the active sites of these materials interact with adsorbates is crucial yet challenging. Solid-state (ss)NMR spectroscopy, ... |
41994947 | Nanoconfinement Enabled High-Efficiency and Long-Lifetime Multicolor Afterglow Hydrogels for Advanced Spatiotemporal Encryption and Pathogen Eradication. | Multicolor organic afterglow hydrogels that simultaneously possess efficient exciton harvesting, ultralong lifetimes and large deformations are still rare. Here, a nano-restriction engineered strategy that embeds a rigid and chromatically diverse hydrogen bond supramolecular framework into hydrogel networks is presente... |
41993032 | Rigidity-Responsive Fluorescence Polarization Detection of Aflatoxin B<sub>1</sub> via Programmable RCA-Coupled CRISPR/Cas12a and a Conformation-Restricted Depolarization Reporter. | Aflatoxin B<sub>1</sub> (AFB<sub>1</sub>) is one of the most toxic and carcinogenic mycotoxins, and its trace-level determination in complex food matrices remains a major analytical challenge. Conventional chromatographic methods, while highly accurate, rely on expensive instrumentation and labor-intensive sample pretr... |
41992683 | Copper(I)-NHC-Catalyzed Enantioselective Borylation and Silylation of Ketimines. | A general method for catalytic enantioselective borylation and silylation of ketimines remains elusive due to their extenuated electrophilicity, the difficulty to discriminate the two non-hydrogen substituents on carbonyl groups stereoselectively, and the lability of products. Herein, based on a series of newly develop... |
41992601 | Immunomodulatory Properties of the Cyclic Lipopeptide Surfactin. | Surfactin is a cyclic lipopeptide biosurfactant produced by <i>Bacillus</i> species that has attracted increasing attention due to its potent immunomodulatory and anti-inflammatory activities. Beyond its well-established surface-active properties, accumulating evidence has demonstrated that surfactin modulates key infl... |
41991781 | The adduct models of aflatoxins with DNA and effects on DNA polymerase Ⅳ. | <h4>Context</h4>Aflatoxin (AFT) is a toxic carcinogen and mutagen produced mainly by Aspergillus species. Dietary intake is the main route of exposure to AFT in humans, and DNA damage caused by AFT exposure receives wide concern as an endogenous factor in the pathogenesis of liver cancer. The systematic exploration on ... |
41810999 | Photo-responsive chemical systems enabling multiscale structural ordering. | Beyond elemental composition and molecular structure, ordered multiscale architectures (self-assembled structure, crystal structure, phase structure, <i>etc.</i>) play a comparably important role in determining material functions, especially the optoelectronic properties. Light, a unique external stimulus with superior... |
41701487 | Recent research progress on organoboron-based stimuli responsive materials. | Organoboron-based stimuli-responsive materials have attracted intense research interest over the past decade owing to their broad utility in optoelectronics, chemical sensing, and smart devices. The boron center combines Lewis acidity, pronounced electron-accepting character, and synthetically tunable orbital hybridiza... |
40911023 | Tissue-Specific Endophytic Microbiome Responses to '<i>Candidatus</i> Liberibacter Asiaticus' in Two Citrus Cultivars. | Citrus huanglongbing (HLB), caused by '<i>Candidatus</i> Liberibacter asiaticus' (CLas), is a destructive disease threatening global citrus industry. Although citrus cultivars differ in HLB sensitivity, how infection alters endophytic bacterial communities in cultivars with contrasting susceptibility remains unclear. H... |
42023081 | How Transformative Are ROS Responsive Hydrogel Nanoformulations to Treat Refractory Infected Wounds. | Controlling infection in bacterial-infected wounds presents a formidable challenge, especially when compounded by additional high-risk factors that hinder the healing process during clinical interventions. Currently, the efficacy of standard therapeutic approaches often falls short, largely attributed to persistent loc... |
42013618 | Computational insights into fenbendazole encapsulation by Cucurbit[n]urils (n = 7, 8): Implications for drug delivery and nanocarrier design through integrated structural, electronic, thermodynamic, and spectroscopic investigations. | Fenbendazole (fenben), a benzimidazole anthelmintic with emerging anticancer potential, faces significant challenges in clinical applications due to its poor aqueous solubility and potential toxicity at high doses. To address these limitations, this study explores the encapsulation of fenben within cucurbit[7]uril (CB[... |
42007271 | Findings From the Pearl River Basin: Dissolved Oxygen Dominates Functional Trait Filtering and Diversity Patterns in Urban Rivers. | Urbanization of river systems introduces novel environmental stressors-such as industrial pollutants and domestic wastewater-that impose selective pressures on aquatic species and reshape fish community structure. This study investigates the effects of urbanization on fish community in the Pearl River Basin, comparing ... |
42006814 | Enhanced nanoencapsulation of gentamicin, ciprofloxacin, and lysozyme in chitosan-MIL-53 metal-organic frameworks for a synergistic activity against drug-resistant <i>Salmonella</i> from poultry and human origins. | The escalating crisis of antimicrobial resistance (AMR), particularly in foodborne pathogens like non-typhoidal <i>Salmonella</i>, necessitates innovative therapeutic strategies. This study first characterized multidrug-resistant (MDR) <i>Salmonella</i> serovars isolated from poultry and clinical sources in Egypt, conf... |
42003056 | Emerging Nanoformulation-Based Carrier Systems: New Insights into Promising Vaccine Delivery. | <h4>Introduction</h4>Vaccines are crucial for controlling infectious diseases and reducing reliance on antibiotics, yet many diseases still lack effective vaccines. Advances in nanomaterials engineering offer new opportunities for vaccine design, utilizing nanoparticles (NPs) to elicit immune responses and modulate ada... |
42001707 | Enhancing oil powder functionality: Synergistic effects of hyaluronic acid and fish collagen peptides in polysaccharide-based wall materials. | This study pioneers a novel strategy to transform passive polysaccharide walls into bioactive delivery systems by integrating hyaluronic acid (HA, 300 kDa) and fish collagen peptides (CP) into polysaccharide matrices (β-cyclodextrin [CD], chitosan [CT], maltodextrin [MD]). Optimization of HA-CP ratios (1:1 w/w) and spr... |
41999899 | Monitoring pH-induced lipid dynamics in mRNA-lipid nanoparticles by synchrotron small-angle X-ray scattering. | Lipid nanoparticles (LNPs), a promising drug delivery system, face key limitations in terms of a poor understanding toward their assembling mechanism and intracellular dynamics. Conventional characterization methods like dynamic light scattering and spectroscopy fail to capture the dynamic mesoscopic structural changes... |
41999900 | Platelet cell membrane-hybridized nanobubble for universal targeted and enhanced phototherapy against bacterial infections. | The rapid emergence of multidrug-resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) and carbapenem-resistant Pseudomonas aeruginosa (CRPA) underscores the urgent need for antibiotic-independent antibacterial strategies. Although phototherapy has emerged as a promising alternative, photothera... |
41999892 | P4HA3 is dispensable for prolyl 4-hydroxylation of type I collagen during mouse development. | 4-Hydroxyproline (4Hyp) is crucially important for the collagen triple helix formation and its thermal stability. It is catalyzed by collagen prolyl 4-hydroxylases (C-P4Hs) that are α<sub>2</sub>β<sub>2</sub> tetramers of two identical catalytic α-subunits (encoded by P4HA1, P4HA2 and P4HA3) and two β-subunits that are... |
41999820 | Novel supramolecular deep eutectic solvents-mediated lignin extraction and reduced cellulase non-productive binding in lignocellulosic enzymatic hydrolysis. | The biorefining of bamboo is constrained by lignin, as its recalcitrance impedes valorization and inhibits enzymatic hydrolysis via cellulase non-productive binding. The present study designed and evaluated a novel supramolecular deep eutectic solvent (SUPRADES), composed of glycolic acid, betaine, and β-cyclodextrin (... |
41999818 | A highly stable W/O emulsion stabilized by β-cyclodextrin-citrus pectin composite nanoparticles for probiotic encapsulation. | Traditional water-in-oil (W/O) emulsions are widely used as probiotic encapsulation templates due to their simple structure, but their practical application is limited by inherent drawbacks including fragile interfacial films, inadequate protection, and poor storage stability. This study proposes a novel strategy to re... |
41992762 | Boron-Doping of a Macrocyclic Tetrafuran Framework Unveils an Expanded Porphyrinoid With Switchable (Anti)Aromaticity and Conformational Dynamics. | Expanded porphyrinoids are an emerging class of organic chromophores with often exceptional optoelectronic properties such as broad absorption extending into the near-infrared (NIR) spectral region. To optimize porphyrinoid-based materials for specific purposes, it is essential to specifically tailor their electronic p... |
41992746 | Facile Fabrication of Multifunctional Metal-Phenolic Network Nanoparticles for Bacterial Keratitis Treatment. | The management of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) keratitis remains highly challenging due to escalating antibiotic resistance and the severe, vision-threatening damage driven by uncontrolled inflammation. In this work, EGCG-Zn-VAN nanoparticles (NPs) were engineered as a multifunctional metal... |
41992695 | Programmable SUST-Based SR-CHA with Ir-Coordination MOFs Enhanced Emitters for Universal Sensitive Evaluation of Various Herpesviruses. | The development of a biosensor capable of universal detection for multiple targets has become a critical research direction for overcoming the limitations associated with traditional high-throughput multitarget detection that relies on numerous independent sensing units. A structural unit for simultaneous testing (SUST... |
41992567 | An Artificial Molecular Pump Powered by Light. | Replicating the ability of biological systems to convert energy into directional molecular motion to perform functions is a central challenge in nanoscience. Artificial molecular pumps that can move substrates energetically uphill remain elusive, particularly when powered by light in an autonomous fashion. We report a ... |
41992513 | Enhanced "Hydrogen Pump" Effect in Improving the Hydrogen Storage Performance of MgH<sub>2</sub> via the Introduction of a Flower-like NiCu Bimetallic MOF. | To overcome the hydrogen storage kinetic limitations of magnesium hydride (MgH<sub>2</sub>), highly effective NiCu bimetallic MOFs with different Ni/Cu ratios were successfully synthesized and introduced into MgH<sub>2</sub>. The Ni<sub>3</sub>Cu<sub>1</sub> MOF, featuring a distinctive flower-like structure assembled ... |
41992465 | Structural and Compositional Effects on the Scintillation Properties of Fast Emitting Metal-Organic Frameworks. | Metal-organic framework (MOF) scintillators are promising emitters for fast timing techniques due to their high scintillation efficiency and rapid response time. These materials are composed of high-atomic-number metal-oxide cores connected by scintillating organic dyes. A quite-overlooked drawback of MOF scintillation... |
41992232 | Biomimetic proteolipid vesicles delivering small activating RNA to activate the macrophage immunotherapy for the treatment of lung cancer. | <h4>Background</h4>Tumor-associated macrophages (TAMs) in the tumor microenvironment (TME) typically polarize toward an M2 phenotype that promotes tumor progression and immune suppression. Reprogramming TAMs to the proinflammatory M1 phenotype has emerged as a promising strategy to boost antitumor immunity. This study ... |
41992081 | A perillaldehyde-derived virucide targets phytoviral coat protein at Ser207 to impede intercellular spread. | <h4>Background</h4>Plant viruses rely on long-distance transport to establish systemic infection within hosts, and cell-to-cell movement is often a prerequisite for vascular entry and subsequent systemic spread. Therefore, interference with virus movement represents an attractive antiviral strategy. Here, we report a s... |
41967519 | Process-dependent inhibitory effects of zinc-based metal-organic frameworks on nitrifying microbial consortia. | Zinc-based metal-organic frameworks (Zn-MOFs) are attractive for environmental applications; however, their impact on key microbial processes, such as nitrification, remains poorly understood. In this study, we evaluated the effects of MOF-5, Zn(II)-MOF, dissolved Zn(II), and their corresponding organic ligands on ammo... |
41964186 | Design Rules for Controlling Connectivity, Topology, and Sorting Using Hydrogen-Bonded Pairs and Aromatic Components in Palladium(II)-Based Interlocked and Foldameric Systems. | Nature's exquisite control over structure arises from its use of complex arrays of topologically complicated species capable of forming and functioning orthogonally. Chemists seek the same level of control in synthetic systems, and here we report the design rules for self-assembly of systems integrating metal-coordinat... |
41964164 | π-Enlargement in Porphyrin Macrocycles at Interfaces. | Porphyrins are essential heteroatomic macrocycles, fundamental to both biological systems and advanced technology. Their unique molecular architecture enables key functions in nature, such as oxygen transport in hemoglobin and light harvesting in chlorophyll, and inspires cutting-edge applications in chemical sensing, ... |
41964111 | Oxidative stress in neurodegeneration: from a simple insult to a dynamic regulator. | <h4>Objectives</h4>To evaluate the central role of oxidative stress in neurodegenerative diseases, and to explore its dynamic regulatory features, underlying signaling pathways, and molecular mechanisms, as well as advanced technological strategies for antioxidant intervention.<h4>Methods</h4>This review comprehensivel... |
41964009 | Palladium nanozyme loaded metal-organic framework eyedrops alleviate oxidative stress for dry eye treatment. | Dry eye is a multifactorial ocular disorder caused by reduced tear secretion, poor tear quality, or excessive tear evaporation, which is a major public health issue worldwide. Oxidative stress on the ocular surface leading to excessive reactive oxygen species (ROS) production is considered a primary factor in the patho... |
41963697 | Fosfomycin combination therapy in high-risk paediatric patients with multidrug-resistant infections: a retrospective study. | Intravenous fosfomycin is a broad-spectrum, bactericidal antibiotic active against Gram-positive and Gram-negative bacteria, including multidrug-resistant (MDR) strains. Evidence regarding its use in paediatric patients, particularly as part of combination therapy, remains limited. This study aimed to evaluate the safe... |
41963423 | Chitosan-EDTA-cellulose functionalized with β-cyclodextrin as a pH-sensitive bio-based nanocarrier for curcumin drug delivery. | In this work, chitosan/cellulose/β-cyclodextrin nanostructure was synthesized by cross-linking chitosan and cellulose with EDTA followed by bridging with ethylenediamine-β-cyclodextrin. The chitosan/cellulose/β-cyclodextrin bio-based nanostructure is a novel drug delivery system that has been developed for the delivery... |
41963379 | First-principles investigation of aspirin, paracetamol, and ibuprofen adsorption on triquinoxalinylene and benzoquinone-based covalent organic framework. | Pharmaceutical contaminants such as aspirin (ASP), paracetamol (PAR), and ibuprofen (IBU) present increasing risks to environmental and human health, necessitating efficient detection and removal strategies. In this study, we performed a comprehensive first-principles investigation of their adsorption on a triquinoxali... |
41963347 | Massive barcode-free chemical screenings enable the discovery of bioactive macrocycles with passive membrane permeability. | Synthetic macrocycles offer exceptional potential as therapeutics. However, most high-throughput discovery platforms rely on genetically encoded libraries of large peptide macrocycles, which typically are not optimized for drug like properties. Fully synthetic libraries offer greater flexibility in accessing broader ch... |
41963311 | Synthetic urine oversimplification results in misleading membrane fouling mechanisms in bipolar membrane electrodialysis. | Lab-scale wastewater treatment studies, including urine recovery, often rely on oversimplified synthetic wastewater, thereby compromising the reliability of results and data. Here, we systematically evaluate how using full-component versus simplified synthetic urine formulations affects the performance and engineering-... |
41963294 | Stress-driven photo-reconfiguration of surface microstructures via vectorial field-guided lithography. | Pattern formation driven by mechanical stress plays a fundamental role in shaping structural organization in both natural and human-made systems. Using light as a vectorial stimulus may offer a powerful route to control stress-induced pattern formation in materials. However, achieving localized, programmable, and predi... |
41963098 | Phonon-Focusing and Rattler-Mode Interference in Thermal Conductivity Transitions of the Breathing Metal-Organic Framework MIL-53. | The metal-organic framework (MOF) MIL-53(Al) has a framework geometry with an unconstrained wine-rack mode that enables it to concertina between large-pore (lp) and narrow-pore (np) structures either under pressure or with the uptake of adsorbates. This article presents the results of equilibrium classical molecular dy... |
41962923 | Disorder in Order-Related Membrane Biophysical Parameters: An In-Depth Analysis of Di-4-ANEPPDHQ Generalized Polarization. | Molecular order-related bulk membrane properties that substantially modulate protein functions can be examined with environment-sensitive probes, such as the prototypical and most widely applied solvatochromic Laurdan, whose spectral parameters change depending on the local hydrophobicity. Di-4-ANEPPDHQ is a widely acc... |
41962039 | From Anisotropic Aluminum-MOF Rods to Oriented Membranes: Stepwise Coordination-Editing for Geometry-Governed Isomer Separation. | Oriented metal-organic framework (MOF) membranes featuring one-dimensional (1D) channels are highly sought after for molecular separations due to minimal transport tortuosity. Nevertheless, realizing such oriented architectures, particularly for Al-MOFs, is challenged by high coordination barriers and anisotropic cryst... |
41961994 | Modulating Surface Architecture of Sulfidated Nanoscale Zerovalent Iron for Synergistic Enhancement of Dechlorination Reactivity, Electron Selectivity, and Colloid Stability. | Sulfidated nanoscale zerovalent iron (S-nZVI) has shown great promise in the remediation of chlorinated solvents-impacted groundwater, yet its performance is hindered by the trade-off between electron selectivity and colloidal stability. Here, we resolve this dilemma with a simple solution, that is, using cyclodextrin ... |
41961925 | Histone decrotonylation plays a distinct role in HIV latency. | The role of epigenetic regulation in HIV latency remains incompletely understood. We show that histone deacetylase 3 (HDAC3) inhibits trans-activator of transcription (Tat)-mediated HIV transcription through histone decrotonylation (HDCR), independent of deacetylase activity. Chemical biology approaches identified sele... |
41961918 | Structure and assembly of Borna disease virus 1 nucleoprotein-RNA complexes. | Structures of nucleoprotein (N)-RNA complexes of the <i>Bornaviridae</i>, a virus family in the order <i>Mononegavirales</i>, have not been reported. Here, using cryo-electron microscopy (cryo-EM), we report high-resolution structures of Borna disease virus 1 (BoDV-1) N-RNA complex assemblies, including a dominant hexa... |
41961912 | Transcriptional signatures of rapid protection from Sudan virus infection by a single dose of a vesicular stomatitis virus-based vaccine. | Sudan virus (SUDV) has caused multiple outbreaks of human disease with case fatality rates ranging from 41 to 100%. We have previously shown that a single vaccination with a recombinant vesicular stomatitis virus-based vaccine expressing the SUDV-Gulu glycoprotein (VSV-SUDV) prevented clinical and fatal disease from le... |
41961876 | Fe<sup>II</sup>-MOFs Catalyze the High Selective Oxidation of Sulfides Induced by Visible Light. | In this article, two new three-dimensional (3D) Fe<sup>II</sup>-MOFs (<b>1</b> and <b>2</b>) were successfully constructed, which can be employed as efficient heterogeneous photocatalysts in the product-selective oxidation of sulfides achieved by using hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) as the green oxidant... |
41961832 | Water-soluble gadolinium fullerenes Gd@C82-TEGs as a potential magnetic resonance imaging contrast agent. | The water-soluble gadolinium fullerenes Gd@C82-TEGs nanoparticles as a novel magnetic resonance imaging (MRI) contrast agent were fabricated by the metal fullerenes Gd@C82 assembled with tetraethylene glycol (TEG). The loading Gd amount in Gd@C82-TEGs nanoparticles was 8.0 wt%. The average particle size of water-solubl... |
41961828 | Effect of impregnation with polyethylene glycols (PEGs) of different end groups on gas separation performance of cross-linked polyethylene oxide (PEO) membranes. | Polymer membranes offer an extremely attractive solution for achieving sustainable carbon dioxide capture and have the potential for large-scale application. The authors prepared almost amorphous polyethylene oxide separation membranes through cross-linking methods, with a CO2/H2 separation coefficient of 7.9. However,... |
41961810 | Structural transformation of a hydrogel-forming cell division protein ZapB of multidrug resistant Klebsiella pneumoniae with small molecules. | Septal ring assembly protein ZapB (EMR18431.1) is involved in Z-ring formation, and nucleoid segregation during the bacterial cell division . It promotes cell division in the initial stages of the cell cycle through direct interaction with FtsZ, thus stimulating Z-ring assembly. The ZapB inhibition can make bacterial c... |
41961807 | The identification of metabolites from gut microbiota in HPV infection via network pharmacology. | Human papillomavirus (HPV) infection continues to pose a significant global health challenge. Although gut microbial metabolites have been associated with HPV infection, the mechanisms underlying this relationship remain inadequately understood. A network pharmacology approach was utilized to comprehensively explore th... |
41961800 | Integrative bioinformatics and machine learning identify shared molecular mechanisms and diagnostic biomarkers between Helicobacter pylori infection and atrial fibrillation. | <h4>Background</h4>Helicobacter pylori (H. pylori) infection and atrial fibrillation(AF) are major global health concerns. Emerging evidence has suggested a potentially chronic inflammation-mediated link between them, but the shared genetic mechanisms remain unclear.<h4>Methods</h4>We analyzed multidataset gene express... |
41961729 | Endurance from Structural Distortion and Conservation of Adsorption Ability of Moisture-sensitive Metal-Organic Frameworks (CPM-33x). | Nickel-based pore-space-partitioned (PSP) metal-organic frameworks (MOFs) offer modular pore environments and superior adsorption capacities; however, some of them exhibit extreme susceptibility to humidity resulting in the facile reduction of trivalent metal ions and structural distortion. Here, we report a sequential... |
41961638 | MOF-derived hierarchical nanoporous carbons for improved hydrogen isotope separation. | Hierarchical nanoporous carbons were prepared <i>via</i> direct carbonization of a MOF precursor to improve hydrogen isotope adsorption and separation. The carbonization process generates a porous structure with coexisting micropores and mesopores. The resulting materials exhibit enhanced adsorption capacity and improv... |
41961480 | Visualization of Endosomal Escape of Intracellularly Delivered Protein With Unexpected Photochemical Internalization of Trypan Blue. | Intracellular protein delivery holds great potential for biomedicine and biotechnology, but real-time monitoring of protein release remains challenging. Here, we introduce trypan blue (TB) as a multifunctional agent for both tracking and enhancing protein delivery. TB forms a supramolecular complex with GFP, quenching ... |
41961329 | Dual Metalation Site Zr-Metal-Organic Frameworks: Controlled Synthesis of Metal-Organic Framework-Bound Proximal Metal Complexes. | Isolating multiple metal ion species within a confined microenvironment can facilitate cooperative interactions that underpin multielectron processes and synergistic or tandem catalysis. Herein, we report the design and synthesis of three flexible Zr-MOFs (UAM-1001-Py, UAM-1002-Py, and UAM-1003-Py) constructed from a t... |
41961274 | Hemin-Engineered UiO-66(Ce) as a Highly Active Nanozyme for Electrochemical Sensing of Hydrogen Peroxide and Hydrogen in Beverages. | A hemin (Hm)-engineered cerium-based metal-organic framework (MOF), UiO-66(Ce)@Hm, was prepared and used as a nanozyme for electrochemical sensing of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) and dissolved hydrogen (H<sub>2</sub>) in beverages. UiO-66(Ce)@Hm showed enhanced electrocatalytic activity toward H<sub>2... |
41961249 | N-Sulfur[<i>n</i>]arene: Synthesis and Solution-State Double-Threaded Dimerization Assisted by Multiple S···S Interactions. | Directional yet weak noncovalent interactions including σ-hole interactions are attractive for formation of discrete supramolecular assemblies but are often suppressed in solution. Here, we demonstrate solution-phase dimerization of a macrocycle driven by cooperative σ-hole interactions. Single-crystal X-ray diffractio... |
41961230 | A Stretchable, Mechanically-Interlocked Polyrotaxane Hydrogel for Wearable Motion and Electrophysiological Monitoring. | Many conductive hydrogels have been developed for wearable electronics; however, it remains a challenge to achieve simultaneous mechanical robustness, stable electrical properties, and tissue-compliant interfaces. Herein, we report a mechanically interlocked polyrotaxane hydrogel prepared via one-pot photopolymerizatio... |
41961087 | Adjusting fracture probability according to duration of diabetes: the Manitoba BMD Registry. | We studied the use of rheumatoid arthritis (RA) as an input to FRAX® and trabecular bone score (TBS) to modify FRAX-based probability in individuals with diabetes. Our results help to inform the use of FRAX and FRAXplus in patients with diabetes.<h4>Background</h4>Diabetes confers increased risk for fracture independen... |
41960905 | Multidentate Surfactant-Dependent Synthesis of Giant Iridium Superstructures. | Giant superstructures of iridium, comprised of smaller spherical and slightly larger anisotropic nanoparticles, were synthesized by reducing iridium chloride in the presence of resorcinarene, a class of tetrameric macrocyclic polyphenols, with sodium borohydride in ethanol in 30 min under mild conditions. These superst... |
41960782 | In Situ Domain-Confined CoIrO<sub><i>x</i></sub> Clusters within MOFs: Efficient Artificial Nanozymes for Multimodal Sensing. | Inadequate control over particle size and intermediate adsorption leads to low active site density and sluggish reaction kinetics, which remain critical challenges for the development of high-performance nanozymes. Here, we report a one-pot strategy that simultaneously enables IrO<sub><i>x</i></sub> nucleation, metal o... |
41960769 | Multifunctionally Modified Low Molecular Weight PEI for Efficient Gene Delivery and Ferroptosis-Induced Antitumor Activity. | Efficient gene delivery coupled with tumor-specific cell death remains a key challenge in cancer gene therapy. Herein, we report a multifunctional cationic polymer (PFFc) that integrates gene delivery and ferroptosis induction. Low-molecular-weight PEI (600 Da) was used as a backbone and cross-linked with fluorinated a... |
41960766 | Polydopamine Nanocages Orchestrate Multi-Site Networks on the Ni<sub>4</sub>Mo Electrocatalyst for Efficient and Ultrastable Hydrogen Evolution. | Breaking the activity-stability trade-off remains a formidable challenge in the pursuit of nonprecious metal electrocatalysts for water splitting. Here, we report a programmable electrochemical assembly of wet-adhesive polydopamine (PDA) nanocages on Ni<sub>4</sub>Mo alloys to enhance the hydrogen evolution reaction (H... |
41960771 | Mn<sup>2+</sup>-Doped and Alloyed (CdS)<sub>13</sub> Magic-Sized Clusters as Molecular Building Blocks for Bright Self-Assembled Photocatalytic Nanostructures. | Magic-sized clusters (MSCs) represent the missing molecular link between precursors and colloidal semiconductor nanocrystals; yet their synthetic fragility and limited compositional scope have hindered systematic exploration. Stoichiometric MSCs with precise metal-chalcogen parity are particularly elusive, restricting ... |
41960755 | Tannic Acid and Copper-Modified ZIF-8 Metal Organic Framework as a Cefotaxime Delivery System for Antimicrobial Activity. | <h4>Objectives</h4>Antibiotic resistance has become a global public health threat. Cefotaxime (CTX), a third-generation cephalosporin, is approved for use in infants, children, and adults with various microbial infections, particularly those affecting the central nervous system. This study aimed to synthesize and chara... |
41960711 | Synergistic properties of biological interest of a ruthenium(II) compound. | This work reports the synthesis, characterization and verification of synergistic properties of a nitrite ruthenium(II) compound [Ru(tpy)(dppz)(NO<sub>2</sub>)](PF<sub>6</sub>) (tpy = 2,2':6',2″-terpyridine; dppz = dipyrido[3,2-<i>a</i>:2',3'-<i>c</i>]phenazine), which is compared to its chlorine precursor [Ru(tpy)(dpp... |
41960704 | Multicomponent Gelation through Cooperative Acid-Amine Pairing: A Combined Experimental and Computational Materials Design Strategy with Sensing Applications. | Cooperative gelation from nongelating molecular components offers a powerful yet underexplored route to synthesis-free soft materials. Here, we report a combined experimental and computational materials design strategy in which cooperative acid-amine pairing induces supramolecular gelation that is inaccessible to the i... |
41960671 | Unanticipated Emergence of the Photo-Switchable Cs<sup>+</sup>-Selective Ion Channels From One-Dimensional 18-Crown-6 Arrays. | A photo-regulated cesium ion channel-the first artificial ion channel of its kind-has been successfully constructed using a small-molecule self-assembly strategy. This breakthrough emerged from an initial effort to design a light-responsive potassium ion channel, incorporating azobenzene-modified 18-crown-6 units, amin... |
41960668 | Boosting the oxidase-mimicking activity of metal-organic framework nanozymes <i>via</i> heteroatom modulation in the organic linkers. | By replacing the linear terephthalate linker with five-membered heterocyclic analogues, we synthesized a series of MIL-53(Fe) nanozymes. The incorporated heteroatoms (O or S) effectively modulate the electron density of the metal active sites. Consequently, the MIL-53(Fe)-TDC variant exhibits an approximately six-fold ... |
41960631 | Interfacial Super-Assembled Hetero-Structured Chiral Nanochannels for Enantioseparation Applications. | Chirality is a fundamental property with profound implications in fields like pharmaceuticals, yet the separation of enantiomers remains a significant technical hurdle. This review chronicles the development of interfacial super-assembled hetero-structured chiral nanochannel membranes, a transformative approach for ena... |
41960616 | Mechanistic origin of charge separation and enhanced photocatalytic activity in D-π-A-functionalized UiO-66-NH<sub>2</sub> MOFs. | Donor-π-acceptor (D-π-A) functionalization of MOF linkers can enhance visible-light photocatalytic activity, yet the mechanisms responsible for these effects remain unclear. Here we combine EPR spectroscopy, transient photoluminescence, and first-principles calculations to examine how diazo-coupled anisole, diphenylami... |
41960614 | Highly Enantioselective Hydrogenation of Imines Catalyzed by Chiral Macrocyclic Boranes. | In this paper, we report a macrocyclic alkene-derived borane catalyst for the asymmetric hydrogenation of imines. A wide range of imines was successfully converted to chiral amines in 80-97% yields and 40-97% ee. The macrocyclic framework is indispensable for excellent catalytic activity and enantioselectivity. A gram-... |
41958389 | Two {B<sub>6</sub>}-Based Borates: From 1D Chain to 3D Framework. | Two mixed alkali- and alkaline-earth metal borates, Na<sub>2</sub>Ca<sub>2</sub>[B<sub>6</sub>O<sub>9</sub>(OH)<sub>4</sub>]·SO<sub>4</sub> (<b>1</b>) and KNa<sub>2</sub>[B<sub>6</sub>O<sub>10</sub>]·HCOO (<b>2</b>), have been synthesized under solvothermal conditions. <b>1</b> features an anionic chain constructed fro... |
41958353 | Co-Cu bimetallic MOF-derived nanozyme-based colorimetric immunoassay with smartphone-based RGB readout for sensitive detection of alpha-fetoprotein. | Nanocatalysts based on metal-organic frameworks exhibit limited catalytic activity due to their symmetrical inactive structures, thereby restricting their application in nanozyme-linked immunoassays (NLISA). This work constructed geometrically structure expanded Cu-Co bimetallic metal-organic framework (GS-CCBM) nanozy... |
41958270 | Iron-Based Metal-Organic Framework MIL-100(Fe) Regulates Keloid Scarring in a Humanized Keloid Model. | Keloids are characterized by excessive collagen deposition and persistent inflammation, causing high morbidity and recurrence with limited effective treatments. In this study, MIL-100(Fe)- a metal-organic framework composed of ferrous/ferric ion nodes and 1,3,5-benzenetricarboxylate ligands- is synthesized via a microw... |
41957793 | Repositioning of Ertiprotafib via supramolecular assembly enables biomarker-guided therapy for acute kidney injury. | Acute kidney injury (AKI) is a rapid loss of renal function that has become a global health concern, with incidence rates reaching up to 50% in critically ill patients. Despite its growing prevalence, no effective pharmacological therapy for AKI currently exists, underscoring an urgent need for new treatments. Here, we... |
42011496 | Modification of wheat starch-long chain inulin complexes by high-power ultrasonication combined with heat treatments: Physicochemical and functional changes. | This study investigated wheat starch (WS)-long-chain inulin (LCI) complexes treated with high-power ultrasound (UA) (1200 or 1500 W, 75 °C water bath, 30 or 180 s (s)). This study showed that the UA-treated WS-LCI composites of each group exhibited partial gelatinization, except for the UA-180 s group, where the starch... |
42011244 | Artificial intelligence-driven discovery of coumarin-based therapeutics: Revolutionizing target identification and validation. | Artificial intelligence (AI) has transformed modern drug discovery by reshaping how therapeutic targets are identified, validated, and optimized. Coumarin derivatives, with their diverse pharmacological activities and structural adaptability, offer a rich chemical space for AI-guided exploration. However, despite the p... |
42011233 | In silico discovery of umami peptides: From sequence-based intelligent models to structure-function mechanistic insight. | Umami peptides are naturally occurring bioactive peptides with distinctive umami taste and promising applications in the food industry. However, conventional identification methods based on sensory evaluation, chromatography, and mass spectrometry are time-consuming, costly, and low-throughput. Recent advances in artif... |
42006477 | Pyroglutamate pendant block copolymers: evolution of inverse and conventional morphologies from RAFT-mediated PISA. | By emulating the complex hierarchical assemblies found in bio-derived materials, nanostructural synthetic designs expand material properties and enlarge their capability for versatile applications. Correspondingly, polymerization-induced self-assembly (PISA) emerges as a controllable, innovative pathway to realize such... |
42006480 | PANDA: AND logic-gated RNA sensing enabled by a photo-activated RCA-Argonaute cascade. | Achieving stable, multiplexed, and affordable nucleic acid detection in a true one-pot format remains a long-standing challenge for molecular diagnostics. Here, we report PANDA, a photo-activated rolling circle amplification (RCA)-Argonaute (Ago) cascade that encodes a stringent molecular AND logic gate between optical... |
42006013 | Metformin alleviates aging-associated periodontitis via NRF2-mediated restoration of the IRE1α dependent unfolded protein response. | Proteostasis disruption due to impaired unfolded protein response (UPR) is a hallmark of aging and contributes largely to cellular dysfunction, but its role and associated mechanisms in aging-associated periodontitis remain unclear. This study reveals that senescent periodontal ligament stem cells (PDLSCs) exhibit impa... |
42006003 | Melatonin-incorporated brain extracellular matrix hydrogel enhances NSCs mitochondrial metabolism to promote neuroregeneration via the AMPK-PGC-1α-NRF1/TFAM axis after spinal cord injury. | Spinal cord injury (SCI) results in severe and debilitating neurological damage. Mitochondria play a crucial role in the differentiation of neural stem cells (NSCs) and neural regeneration. However, mitochondrial dysfunction occurs following SCI, manifesting as dysregulation of oxidative stress and ATP depletion, which... |
41994484 | Regulatory risk loci link disrupted androgen response to the pathophysiology of polycystic ovary syndrome. | A major challenge in deciphering the complex genetic landscape of polycystic ovary syndrome (PCOS) lies in the limited understanding of how susceptibility loci drive molecular mechanisms across diverse phenotypes. To address this, we integrated molecular and epigenomic annotations from proposed causal cell types and em... |
41985213 | BF<sub>2</sub>- and PO<sub>2</sub>-Chealted Oxasmaragdyrins - Excited state properties, singlet oxygen generation, and imaging potential in mice bearing colon tumor. | Free-base oxasmaragdyrin (SmFb), a 22-π electron aromatic macrocycles containing four pyrroles and a furan ring connected via three methine bridges and two direct bonds, and its BF<sub>2</sub>- (SmBF<sub>2</sub>) and PO<sub>2</sub>-chealted (SmPO<sub>2</sub>) derivatives, peripherally modified at the meso-aryl rings wi... |
41982931 | Design of permeability-optimized target-binding macrocycles <i>via</i> direct preference optimization. | Macrocyclic peptides represent a promising therapeutic modality for challenging targets, such as protein-protein interactions. However, their clinical utility is often limited by inadequate membrane permeability, which restricts both intracellular target access and oral bioavailability. Existing structure-based generat... |
41974086 | An immunosensor based on Cu doping enhanced Gd MOF electrochemiluminescence was used to detect CA19-9. | In this work, Gd MOF was designed with Gd (III) as the central metal ion and 5-aminoisophthalic acid (5-AIPA) as the organic ligand, and its electrochemiluminescence (ECL) performance was investigated. At the same time, considering the reversible conversion of Cu<sup>2+</sup>/Cu<sup>+</sup>, Cu doping of Gd MOF can eff... |
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