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41947646 | Copper-Driven Structural Reinforcement of CoFe LDH Enhances Nitrate Adsorption and Accelerates Deoxygenation-Hydrogenation Kinetics for Electrocatalytic Nitrate Reduction. | The electrochemical nitrate-to-ammonia reduction reaction (e-NO<sub>3</sub>RR) attractively reconciles nitrate remediation with value-added NH<sub>3</sub> synthesis; yet, its practical application is hindered by an intricate eight-electron pathway, which results in mechanistic ambiguity and sluggish kinetics. Herein, a... |
41947643 | Tuning Solvation Dynamics by Modulating the Shape of Water-Soluble Cationic Nanocages. | Understanding how nanoconfinement geometry modulates solvent dynamics is critical for controlling the photochemical reactivity inside supramolecular hosts. Here, we investigate how altering the shape of a cationic metal-organic nanocavity from an octahedral-shaped full-cage to a square-pyramidal-shaped half-cage influe... |
41947639 | Photocatalytic Performance of Different Copper(I) Iodide Cluster MOFs in Radical Decarboxylative Cyanation. | Metal-organic frameworks (MOFs) provide an ideal platform for solar-to-chemical energy conversion but are often limited by rapid charge recombination and insufficient light-harvesting capabilities. Herein, we report a series of MOFs with superior photocatalytic performance by employing a triphenylamine-derived ligand, ... |
41885310 | Clocks on steroids: how glucocorticoid receptors tell cells the time. | Glucocorticoid (GC) steroid hormone signalling via the glucocorticoid receptor (GR) underlies most daily physiological rhythms in mammals by synchronising cellular circadian rhythms throughout the body. Impaired circadian synchrony is associated with many non-communicable diseases, such as cardiovascular disease, diabe... |
42006853 | Breeding of a higher producer enables identification of a negative transcription factor controlling the biosynthesis of xiamenmycin in <i>Streptomyces xiamenensis</i>. | Xiamenmycin, a prenylated benzopyran compound produced by <i>Streptomyces xiamenensis</i> 318, exhibits promising anti-fibrotic activity but suffers from low productivity, limiting its pharmaceutical development. In this study, we obtained a mutant strain N-8 producing 226.3 mg/L xiamenmycin B (28-fold increase relativ... |
42006012 | Intelligent microneedle patch with cobalt-iron Prussian blue nanozymes for accelerating diabetic wound healing <i>via</i> heme biosynthesis-driven immunomodulation. | A complex wound microenvironment with the presence of bacterial infection, overproduction of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), chronic inflammation, poor vascularization and hypoxia wound result in delayed healing of diabetic wounds. In this study, a novel antibacterial microneedle patch integrating cobal... |
41988501 | Deciphering the stimuli-responsive behavior of TPPE-incorporated flexible metal-organic frameworks. | Aggregation-induced emission luminogens (AIEgens) hold great promise for the design of highly sensitive and stimulus-responsive luminescent metal-organic frameworks (LMOFs). However, the underlying response mechanisms, particularly the evolution of the energy state and conformation of AIE linkers under external stimuli... |
41988500 | Engineering porous organic polymers for enhanced CO<sub>2</sub> capture: from synthesis to implementation. | The escalating concentration of atmospheric carbon dioxide (CO<sub>2</sub>) necessitates the development of efficient and scalable carbon capture technologies. Porous organic polymers (POPs) have emerged as a leading class of solid-state adsorbents, offering an exceptional combination of high surface area, tuneable por... |
41978838 | <i>Kadsua coccinea</i> Extract Alleviates Rheumatoid Arthritis via TNF-α Suppression and Gut Microbiota Modulation. | <h4>Background and purpose</h4><i>Kadsura coccinea</i>, Lem. A. C. Smith (KCR) is a traditional multi-ethnic medicinal plant in China, widely used by Yao, Dong, and other ethnic groups in Hunan, Yunnan, Guangxi, and other southern regions. Traditionally prepared as medicinal wine, it has shown notable therapeutic advan... |
41978720 | From Nature to Nanomedicine: Engineered Plant-Derived Nanovesicles for Skin Disease. | Plant-derived nanovesicles (PDN), as a novel class of natural nanocarriers, possess excellent biocompatibility and the capacity to load various bioactive components, offering new perspectives for the treatment of skin diseases. However, natural PDN suffer from limited skin penetration and weak targeting ability. By app... |
41977793 | Cloning and Characterization of <i>IbDREB1d</i> and Its Role in Plant Growth Regulation in Sweet Potato. | DREB (Dehydration-Responsive Element-Binding Protein) transcription factors are a subfamily of the AP2/ERF transcription factor family and play a crucial role in the regulation of plant responses to abiotic stress. In this study, we successfully cloned the <i>IbDREB1d</i> gene from the leafy sweet potato cultivar Fucai... |
41977642 | Collagen Scaffolds in Regenerative Endodontic Procedures: Current Evidence, Limitations, and Future Perspectives. | Predictable pulp-dentin regeneration continues to represent a major challenge in regenerative endodontic procedures (REPs). Although collagen-based scaffolds are widely investigated for their excellent biocompatibility, their ability to deliver consistent clinical and histological outcomes requires critical evaluation.... |
41977496 | Synthesis of New Asymmetrical Chalcones and Evaluation of Their Use in Combination with Curcumin Against Rhodesain of <i>T. brucei rhodesiense</i>. | Rhodesain is a cysteine protease that plays a key role in the life cycle of <i>Trypanosoma brucei rhodesiense</i>, an endemic parasite in sub-Saharan Africa and responsible for Human African Trypanosomiasis (HAT), a disease that can be fatal if not treated promptly. Due to the limitations associated with current HAT ph... |
41976759 | Engineering Design Strategies for Boosting Photocatalytic Activity: Theory-to-Data-Driven Perspective. | Photocatalysts have emerged as a promising approach for the treatment of contaminated water, particularly for the removal of dyes and pharmaceutical residues that pose risks to human health. In addition, they can be employed for the generation of chemical fuels such as H<sub>2</sub> and oxidizers such as H<sub>2</sub>O... |
41976564 | Integrative Network Pharmacology and Molecular Docking Analysis Uncovers Multi-Target Mechanisms of Alpha-Mangostin Against Acute Kidney Injury. | Alpha-mangostin (AM), a xanthone from <i>Garcinia mangostana</i>, has shown promising nephroprotective properties, but its mechanisms in acute kidney injury (AKI) remain incompletely defined. In this study, we applied an integrative network pharmacology pipeline combined with molecular docking to clarify AM's multi-tar... |
41976562 | Modern Fluorescence Strategies for Honey Characterization: Analytical Advances, Emerging Technologies, Methodological Challenges, and Future Perspectives. | Honey authenticity control remains analytically challenging due to the complexity of its matrix and the increasing sophistication of adulteration practices. While chromatographic, spectrometric, and isotopic methods provide high confirmatory accuracy, their routine application is constrained by cost, time, and infrastr... |
41976557 | A Systematic Review of On-Site Rapid Detection Methods for Antibiotic Residues in Aquatic Products (2021-2025). | Antibiotic residues in aquatic products pose a serious food safety concern, whereas conventional laboratory methods often fail to meet the demand for on-site rapid screening. This study systematically reviews the research progress from 2021 to 2025 on both the risks of antibiotic residues in aquatic products and the de... |
41972658 | Mn-CeO<sub>2</sub> Nanomaterial for the Colorimetric Sensing of H<sub>2</sub>O<sub>2</sub> and Ascorbic Acid. | Owing to the high stability and low cost of nanozymes, they have been extensively investigated and reported. In this work, highly active CeO<sub>2</sub> nanoflowers were first prepared and then different metal elements were doped into the CeO<sub>2</sub> nanoflower matrix via a novel synthesis method to fabricate M-CeO... |
41971180 | Chitosan Nanoparticles for Natural Antioxidant Delivery in Metabolic Dysfunction-Associated Steatohepatitis Liver Disease (MASLD). | Metabolic Dysfunction-Associated Steatohepatitis Liver Disease (MASLD) is a global clinical challenge, with oxidative stress and inflammation as drivers of disease progression. Numerous natural antioxidants exhibit hepatoprotective activity, but their application is often limited by poor solubility, gastrointestinal in... |
41971179 | Nanodelivery of Traditional Chinese Medicine Monomers: An Emerging Strategy to Reprogram the Immunosuppressive Tumor Microenvironment. | The tumor microenvironment (TME), a highly complex and dynamic system, plays a central role in tumor progression and resistance to immunotherapy. Key immunosuppressive cell populations within the TME, including tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), and regulatory T cells (Tregs)... |
41970210 | Advancing Drug Delivery with Biodegradable Molecularly Imprinted Polymers: From Design to Clinical Prospects. | Molecularly imprinted polymers (MIPs) have emerged as promising materials for drug delivery systems, offering various advantages in terms of selectivity, stability, modified/smart release properties, and targeted therapy. Despite decades of development, the clinical translation of MIP-DDS remains limited, mainly due to... |
41969297 | Mapping the miRNA landscape of primitive macrophage extracellular vesicles highlights their pro-vasculogenic effects in engineered human cardiac tissue. | Resident cardiac macrophages, derived from primitive yolk sac precursors during embryogenesis, have increasingly been recognized for their distinct phenotype and functions in regulating homeostasis of the human heart. However, the profile of their extracellular vesicles (EVs) in cardiac signaling and regulation remains... |
41966551 | MOF-based nanozymes: Rational design and biomedical applications. | Nanozymes are nanomaterials with enzyme-mimicking catalytic activities that have extraordinary potential in biotechnology. Metal‒organic frameworks (MOFs), emerging nanoporous materials with atomically defined active sites and ordered porous architectures, have been established as an important subclass of nanozymes. In... |
41962203 | A dual-response size-shrinkable drug delivery system capable of deep tumor penetration for the treatment of solid tumors. | The effective delivery of chemotherapeutic agents into solid tumors is a significant challenge in nanomedicine due to the "size paradox" between long circulation and deep tumor penetration. In this work, we developed a dual-responsive, size-shrinkable drug delivery system, DOX@US-DSMSN-Cluster, based on ultra-small, di... |
41960358 | Phytochemical Diversity, Nutritional Values, and Biological Properties of <i>Halopithys incurva</i> (Hudson) Batters, 1902. | <i>Halopithys incurva</i> (Hudson) Batters, 1902 is a red macroalga with a broad geographical distribution. In total, 41 chemical constituents have been characterized from <i>H. incurva</i>, including bromophenols, isoflavones, mycosporine-like amino acids, saturated and unsaturated fatty acids, and phytohormones. In a... |
41956176 | Molecular structure of the third immunoglobulin domain (Ig3) of human Muscle-Specific kinase (MuSK). | The Muscle-Specific Kinase (MuSK) is a monotopic transmembrane receptor responsible for key signaling events during development and maintenance of neuromuscular junctions. The N-terminal extracellular portion of MuSK is characterized by multiple domains, extensively involved in molecular interactions with co-receptor L... |
41955814 | Multiplexed nanophotonic sensor arrays for time-resolved biomolecular analysis. | Complex diseases arise from networks of interacting biomolecules, yet most analytical technologies measure only a limited number of interactions simultaneously. Here, we present a chirped guided-mode resonance (cGMR) photonic biosensor array for multiplexed, label-free analysis of biomolecular kinetics across hundreds ... |
41955784 | Phosphate- Cr-MOF/polysulfone porous beads as sorbent in the pipette tip-μSPE method for determination of phthalate esters in food matrices. | Phthalate esters (PAEs) are highly susceptible to leaching from plastic packaging into food products during processing, transport, and storage. Therefore, in this study, a newly synthesized sorbent material, phosphate-MIL-101(Cr)-NH<sub>2</sub>/ polysulfone (PSF) porous beads, was introduced into a pipette tip micro-so... |
41953629 | Molecular blueprints for cleaner air: theoretical insights into Cu(i)-decorated heterocycles for greenhouse gas (CO/CO<sub>2</sub>/CH<sub>4</sub>) capture. | This study presents a comprehensive DFT investigation on Cu(i)-decorated five-membered aromatic heterocycles-imidazole, pyrazole, thiazole, oxazole, isoxazole, and isothiazole-as molecular hosts for capturing key greenhouse gases (CO, CO<sub>2</sub>, and CH<sub>4</sub>). Geometry optimization and electronic-structure a... |
41953625 | Photothermal-responsive self-healing PDMS-based elastomers for stretchable strain sensors. | The modification of traditional self-healing elastomers is typically accompanied by a loss of both strength and self-healing efficiency, limiting their long-term reliability. Developing multifunctional polydimethylsiloxane (PDMS)-based systems capable of overcoming this trade-off is thus critical for practical sensor a... |
41953612 | Pico-molar determination of lurasidone hydrochloride in pharmaceutical formulations using PVC-membrane bulk Miptode. | Lurasidone hydrochloride (LRH) is an important medication used for schizophrenia treatment, with minimal side effects of body weight loss, limited sedative capacity and minimal metabolic change; accordingly, its determination is vital, as it is recommended for psychological and memory problems. Molecularly imprinted (M... |
41953623 | A green and facile modification of red mud waste with MIL-100 (Fe) for multi-pollutant adsorption from wastewater: isotherms, kinetics, and thermodynamics. | The expansion of the textile and pharmaceutical industries, driven by rapid population growth and evolving lifestyles, has led to an increased release of synthetic chemicals into the environmental matrices, thereby posing risks to aquatic ecosystems and human health. A novel composite adsorbent, fabricated by integrati... |
41953617 | A multi-stage computational pipeline and <i>in vitro</i> validation for the discovery of small-molecule translation inhibitors targeting the bacterial ribosome. | The global rise in antibiotic resistance necessitates new agents targeting essential bacterial processes like protein synthesis. Structure-based virtual screening enables the rapid identification of drug candidates from large chemical libraries, accelerating drug discovery. Here, we report an integrated computational a... |
41953613 | <i>In vitro</i> and <i>in vivo</i> assessment of sporopollenin exine capsule preparations (SpECs) from <i>Lycopodium clavatum</i> spores. | This study investigated the potential allergenicity of sporopollenin exine capsule preparations (SpECs) derived from plant pollen or spores as allergenicity could limit their use as a therapeutic oral drug delivery system. As allergenicity may differ depending on the method of preparation, raw spores from <i>Lycopodium... |
41953616 | Extraction, purification, structural characterization, bioactivities, and applications of <i>Pholiota nameko</i> polysaccharide: a review. | <i>Pholiota nameko</i>, an edible mushroom, is recognized for its significant medicinal properties and broad application potential. <i>Pholiota nameko</i> polysaccharide (PNP), a major bioactive component derived from this fungus, exhibits diverse biological activities, including anti-inflammatory, antioxidant, antitum... |
41953611 | Sustainable β-cyclodextrin/polyethylenimine-encapsulated activated algae hydrogel beads for high-capacity Cd(ii) removal: adsorption performance, mechanism, thermodynamics, and Box-Behnken optimization. | This work details the formation of a novel bio-adsorbent from algae functionalized with glutamic acid after being activated with hyaluronic acid. The functionalized algae were encapsulated in β-cyclodextrin as well as polyethylenimine and crosslinked by epichlorohydrin to form FAACP hydrogel beads that have been used f... |
41953605 | Dipyridinophane ligands - synthesis and coordination study. | Twelve-membered dipyridinophane and its derivatives bearing two acetate or methylphosphonate pendant arms were synthesised, and their coordination properties were studied. Protonation constants of the ligands and stability constants of their complexes with Ni<sup>II</sup>, Cu<sup>II</sup> and Zn<sup>II</sup> ions were ... |
41953580 | N-Nitrosodimethylamine as an Emerging Environmental Contaminant: Sources, Analytical Advances, and Ecotoxicological and Human Health Risks. | Over the last few years, N-nitrosodimethylamine (NDMA) has become a significant environmental contaminant with both anthropogenic and natural sources. The alarming profile of it can be explained by the fact that it is a genotoxic substance and easily spreads through the atmospheric and water systems. The production of ... |
41952338 | Accurate determination of the preferred aggregation number of a micelle-encapsulated membrane protein dimer. | The structures of membrane proteins, such as the C99 dimer, are commonly resolved using protein nuclear magnetic resonance (NMR), which employs micelles as membrane mimics. Protein NMR is not able to determine the aggregation numbers of micelles, however, and while several experimental techniques exist for quantifying ... |
41950977 | Metal-organic frameworks as versatile geobacter platforms for microbial protection and functionalization. | Microorganisms represent indispensable biocatalysts in biotechnology, yet their broader application is hindered by inherent limitations such as environmental sensitivity and operational instability. The emergence of metal-organic frameworks (MOFs) has provided a revolutionary platform to address these challenges. This ... |
41947525 | Synthesis and Regulation Mechanism of High Entropy Layered Double Hydroxide Electrocatalyst. | High-entropy layered double hydroxides (HE-LDHs) represent a unique class of two-dimensional materials achieved by combining multicomponent entropy stabilization with layered hydroxide structures. Despite exhibiting the high-entropy effects, lattice distortion effects, hysteretic diffusion effects, and cocktail effects... |
41947278 | Combined effects of slightly acidic electrolyzed water and medium-chain fatty acids on shelf life extension and freshness maintenance in refrigerated sea bass (Lateolabrax maculatus). | <h4>Background</h4>Sea bass (Lateolabrax maculatus) is highly susceptible to spoilage during refrigerated storage due to microbial growth and endogenous enzymatic activity, leading to rapid quality deterioration. A novel method using slightly acidic electrolyzed water (SAEW) and medium-chain fatty acid (MCFA) was devel... |
41947006 | Coherent Cancellation in Oscillatory Structural Forces Enables Surface Recognition in Colloidal Assembly. | While oscillatory structural forces (solvation/depletion) are ubiquitous in colloidal systems, the mechanism by which they guide the precise self-assembly of complex particles remains elusive. Here, we reveal that the extreme sensitivity of these damped oscillatory forces to surface orientation stems from their coheren... |
41946767 | Desidustat's cardioprotective mechanisms in heart failure: a network pharmacology, molecular docking and dynamics approach. | Heart failure (HF) remains a significant global health issue. Current guideline-directed therapies often focus on neurohormonal modulation and may not fully address the metabolic, oxidative, and inflammatory components central to the disease. Desidustat, a hypoxia-inducible factor prolyl hydroxylase inhibitor, has show... |
41946679 | Periosteal mitochondria DNA structures drive aging-associated poor skeletal repair. | Insufficient skeletal repair is the primary threat of health span and lifespan in elders with increasingly vast global burden; yet, to date, the knowledge of resolving this crisis remains limited. In this study, we addressed the specific mechanisms underlying aging-associated poor bone repair, which are driven by the m... |
41945673 | Construction of Three-Dimensional Hierarchical Pine-Needle-Like Ce-Ni Metal-Organic Frameworks for High-Efficiency Electrocatalytic Oxygen Evolution. | The design of high-efficiency, durable electrocatalysts derived from earth-abundant metals is crucial for achieving cost-effective hydrogen generation through water electrolysis. This work presents a bimetallic CeNi-metal-organic-framework (MOF) synthesized using a dual-ligand strategy with 1,3,5-benzenetricarboxylic a... |
41945621 | Computational and immunoinformatics approaches for designing phytocompound-based drugs and a multi-epitope vaccine targeting FemA, a cell wall protein of Staphylococcus aureus. | Staphylococcus aureus, a bacterial pathogen, is increasingly linked to severe healthcare-associated diseases, from mild skin infections to toxic shock syndrome. Due to limitations in conventional methods, we use computational techniques to screen potential phytocompounds for new drug development and to construct a mult... |
41945578 | Antimicrobial and antibiofilm evaluation of thymol, sodium azide, and sodium lauryl sulfate against multidrug-resistant pathogens: An integrated experimental and computational study. | Multidrug-resistant (MDR) pathogens represent a major global health challenge, underscoring the urgent need for new antimicrobial strategies that can effectively target both planktonic cells and biofilm-associated infections. This study integrated in vitro antimicrobial and antibiofilm assays with comprehensive in sili... |
41945452 | Spinel ZnMn<sub>2</sub>O<sub>4</sub>/Ni-based metal-organic framework hybrid composite for high-performance asymmetric supercapacitors. | Creation of advanced electrode materials with superior electrochemical performance is essential for advancing next-generation supercapacitors. Integrating spinel oxide with metal-organic frameworks significantly enhances the supercapacitor's electrochemical performance, energy, and power density. In this study, we synt... |
41945434 | Humanized extracellular vesicles for efficient RNA delivery. | Engineered extracellular vesicles (EVs) are a class of nonviral delivery vectors for RNA-based vaccines and gene therapies. A specialized form of engineered EVs, known as enveloped protein nanocages (EPNs), has been developed to enhance cargo loading and delivery. When EPNs are equipped with a viral fusogen, such as ve... |
41945432 | Meiotic prophase I disruption as a strategy for nonhormonal male contraception using small-molecule inhibitor JQ1. | Developing safe, reversible, and nonhormonal male contraceptives has been hindered by the lack of defined biological windows that can be transiently interrupted without compromising long-term fertility. Here, we tested whether meiotic prophase I can serve as such a window by pharmacologically inhibiting the testis-spec... |
41945319 | Pore Contraction in an Adenine-Based Metal-Organic Framework for Light Hydrocarbon Separation. | Control of pore size is a central challenge in designing porous frameworks for hydrocarbon separations. Here we report an adenine-based metal-organic framework, Zn(pip)(ad), assembled from adenine (Had) and piperidine-4-carboxylic acid (Hpip). Replacement of the planar aromatic isonicotinate (int) ligand with a saturat... |
41945229 | Metal-Organic Framework Nanozymes: From Rational Design and Synthesis to Biomedical Applications. | Metal-organic framework (MOF) nanozymes have recently demonstrated considerable potential for biomedical applications. The catalytic activity of MOF nanozymes is primarily determined by the coordination of metal ions and organic ligands. Additionally, optimizing the morphology and pore size enhances the catalytic effic... |
41945214 | Engineering of Asymmetric Dual-Atom Sites for Effective Oxygen Electrocatalysis. | Asymmetric dual-atom site catalysts (ADASCs) inherit the high atomic utilization of single-atom site catalysts and synergistic effects of symmetric dual-atom site catalysts, while uniquely integrating the asymmetry of heteronuclear metal centers and asymmetric coordination environments. This structural merit endows the... |
41945199 | Stable resynthesized Brassica napus lines show similar meiotic behaviour to established B. napus. | Brassica napus (rapeseed/canola) is an allotetraploid (AACC, 2n = 4x = 38) resulting from spontaneous hybridization between B. rapa (AA, 2n = 2x = 20) and B. oleracea (CC, 2n = 2x = 18). Although established B. napus is meiotically stable, resynthesized lines (2n = AACC) produced by hybridizing between progenitor speci... |
41944810 | RaPID Selection of α-Hydrazino Acid-Containing Macrocyclic Peptides. | Incorporation of α-hydrazino acid (α-Hza) into peptide chain can stabilize the secondary structures, such as helices and turns, and give rise to rigidification of peptide conformation. Consequently, such peptides potentially acquire enhanced binding affinity to target proteins. Moreover, the hydrazidic bond in α-Hza-co... |
41944828 | Rotational Spectroscopic Evidence for a π→π*(C═O) Interaction in a CO<sub>2</sub>-Conjugated π System. | The rotational spectrum of the isoprene-CO<sub>2</sub> complex was investigated using pulsed-jet Fourier transform microwave spectroscopy, complemented with quantum chemical calculations. Under supersonic jet expansion, only a single isomer was detected, in which CO<sub>2</sub> resides above the conjugated C═C-C═C plan... |
41944783 | Metal-organic framework-based molecularly imprinted polymers for the dispersive solid-phase extraction of fluoroquinolones in coastal zone water and biological samples. | The coastal zone is a critical interface between terrestrial and marine systems, providing ecosystem services and economic value while serving as a major sink for land-derived contaminants. The identification and quantification of new pollutants (NPs), particularly antibiotics, even as trace residues, in coastal enviro... |
41944786 | Reinforced Quaternized Poly(crown ether)-Based Solid Polymer Electrolyte for Highly Durable Lithium-Metal Batteries. | All-solid-state lithium metal batteries (LMBs) are recognized as prospective next-generation energy storage systems due to their high energy density and inherent safety. However, as a critical component of LMBs, solid polymer electrolytes (SPEs) face challenges, such as low ionic conductivity and a low Li<sup>+</sup> t... |
41944756 | Reprogramming Cascade Catalysis via Protein-Directed Interfacial Assembly of Spatially Ordered Clusterzymes for Enhanced Antioxidant Treatment. | Precise spatial arrangement of catalytic centers is essential to emulate the efficiency of natural enzymatic cascades. Herein, we report a protein-mediated interfacial self-assembly strategy to construct vesicle-like proteinosomes with spatially arranged gold clusterzymes (AuNEs) to enhance multienzyme cascade catalysi... |
41944751 | Mn-incorporated high-entropy quaternary sulfide CoNiFeMnS for efficient electrocatalytic oxygen evolution reaction. | Electrochemical water splitting is promising for sustainable hydrogen production but limited by sluggish oxygen evolution reaction (OER) kinetics. Noble-metal catalysts (<i>e.g.</i>, RuO<sub>2</sub> and IrO<sub>2</sub>) are benchmarks but suffer from high cost and poor durability, prompting the search for noble-metal-f... |
41944697 | Cell Membrane Biomimetic Single-Atom Nanozymes for Combined Tumor Chemodynamic Therapy and Immunotherapy. | In recent years, single atom nanozymes have attracted increasing attention in the antitumor field due to their excellent features such as efficient catalytic activity. However, chemotherapy alone is often insufficient to eradicate tumors and even less effective in inhibiting tumor recurrence and metastasis. Therefore, ... |
41944678 | Exploring Confinement-Induced Self-Assembly of Anthracene in a Janus Inorganic Nanotube as a Route to Water-Dispersible Nanoscintillators. | Developing scintillators that are water-dispersible, easily processable, environmentally benign, and compatible with polymer or glass matrices is an important requirement in advancing materials for photodynamic therapy and fabricating miniaturized radiation detection devices. Herein, we demonstrate the self-assembly-dr... |
41944610 | Intelligent α-Cyclodextrin-Based Nanomachines Co-loading Lenalidomide and Au@TPE for NIR-I-Light Programmed Combinatorial Breast Cancer Therapy. | Malignant tumors have emerged as a major threat to human health. Micro/nanomachines offer minimally invasive advantages over traditional cancer therapies, making them promising for medical applications. Herein, we designed an α-cyclodextrin-based nanomachine (αALN) encapsulating Au@TPE as a photothermal agent, leveragi... |
41944591 | The Emergence of Chirality in Time and Space: Transient Asymmetry in Supramolecular Polymers Triggered by Visible Light. | Asymmetry is a fundamental property in the molecular organization of life, but how it emerges and propagates remains elusive. One-dimensional assemblies formed through reversible, non-covalent interactions can adopt helical conformations and reorganize slowly, making them powerful model systems for studying the emergen... |
41944565 | Rational design of amphiphilic pyrrolidinium derivatives: structure-activity correlation and alkyl chain tuning for superior antimicrobial activity. | A novel amphiphilic pyrrolidine derivatives, 1-alkyl-1-(2-(hexyl carbamoyloxy)ethyl)pyrrolidinium bromides (CPS-<i>n</i>-6, where <i>n</i> = 12, 14, 16, and 18), were synthesized and characterized. Comprehensive investigations demonstrated that the amphiphiles synthesized exhibit multifunctional properties and meet str... |
41944528 | Dual-Site Molecular Recognition in a Truncated-Octahedral Pd<sub>6</sub>L<sub>8</sub> Cage via Symmetry-Selective Endo and Peripheral Binding. | A primary objective of supramolecular chemistry is to mimic the functions of proteins in biological systems for molecular recognition, which utilizes both surface interactions and internal binding pockets. Herein, we report a truncated octahedral Pd<sub>6</sub>L<sub>8</sub> cage (<b>MOC-35</b>), constructed through coo... |
41944377 | Exploration of Metallo-Gemini Surfactants in Thin Films. | Engineering molecular architectures enables the systematic investigation of how metal coordination and ligand geometry influence the fundamental interfacial properties of surfactants at the aqueous surface. Here, we report hexadecylpyridine-n-carboxylate metallo-gemini surfactants (MGSs) in which the organic linker is ... |
41944341 | An Artificial Interphase with Ion-Selective Pathways Enhancing Interfacial Kinetics for Highly Reversible Zinc Anodes. | Aqueous zinc metal batteries (AZMBs), recognized as a prospective technology for next-generation energy storage, face challenges including harmful parasitic reactions, and dendrite growth. Herein, a novel artificial interphase, comprising carboxylated cellulose (CNF) and β-cyclodextrin (β-CD), was constructed on the Zn... |
41944294 | Dual-Mode FL-SERS Biosensor for Self-Validating H<sub>2</sub>S Detection in Complex Matrices and Mitochondria-Targeted Cellular Imaging. | Hydrogen sulfide (H<sub>2</sub>S) plays dual-faced roles in physiological regulation and food quality, demanding detection tools with high sensitivity, specificity, and self-validating capability. Herein, a dual-mode biosensor integrating fluorescence (FL) and surface-enhanced Raman scattering (SERS) is developed for u... |
41944211 | Precise control of metal-ligand interactions: advanced chelation strategies for next-generation theranostic nanomedicine. | The chelation chemistry of metal ions is essential for the development of superior biomaterials and sophisticated nanoplatforms in theranostic nanomedicine. Distinct from previous reviews focusing on isolated applications, this work establishes a "descriptor-to-function" design framework that connects intrinsic coordin... |
41944190 | A 3D microfluidic model of exchange between perfused blood and lymphatic microvascular networks. | Blood and lymphatic microvascular networks function as integrated systems within tissues, exchanging fluid, molecules, and cells to regulate homeostasis and immune responses, yet current <i>in vitro</i> models primarily study these systems in isolation. Existing blood-lymphatic culture models either lack <i>in vivo</i>... |
41944192 | An Exclusive Synthesis of Macrocyclic Trimer over Polymers. | Despite the inherent competition between cyclization and linear polymerization, we report the exclusive synthesis of a macrocyclic trimer from 1,2,3,4-tetramethoxybenzene and paraformaldehyde. Dynamic Friedel-Crafts alkylation proceeds solely through linear oligomeric intermediates, which ultimately convert to the cycl... |
41944135 | Isostructural Transformation From a Hydrogen-Bonded Metal-Complex Framework to a Metal-Organic Framework for Enhanced Ammonia Tolerance. | Metal-organic frameworks (MOFs) are promising sorbents for ammonia (NH<sub>3</sub>) storage and capture. However, rationally synthesizing target MOFs with NH<sub>3</sub> tolerance and reversible uptake still remains challenging. Here, we present a hydrogen-bonded metal-complex framework (ALP-HOF-1) that can isostructur... |
41944100 | State-of-the-art of surface-enhanced Raman spectroscopy for pathogenic bacterial identification. | Rapid and accurate identification of pathogenic bacteria is essential for safeguarding public health. However, existing approaches, including conventional culture methods, microscopic examination, modern molecular biology techniques, and sophisticated instrumental analyses, still suffer from lengthy processing times, o... |
41944051 | Dictating orientation diversity of body-centered cubic superlattices in the self-assembly of polymer-grafted nanocubes through heterogeneous grafting designs. | Understanding the self-assembly of polymer-grafted nanocrystals with anisotropic cores and precisely controlling the orientation of their assembled structures are crucial for creating novel nanomaterials with remarkable photoelectric, optical, and catalytic properties. Herein, we design three types of polymer-grafted n... |
41943897 | Prenucleation Clusters as Intermediates in Shell Development via Monomer Addition Onto Photoluminescent Quantum Dots. | Colloidal semiconductor core/shell quantum dots (QDs) have promising potential in a wide range of optoelectronic applications. However, the pathway of shell formation remains elusive, impeding the applications. Here, we demonstrate for the first time that shell growth proceeds via monomer addition, similarly to the QD ... |
41887603 | Staying on Track: Collagen Fibers Orientation Strongly Affects Thrombi Formation at High Shear. | Subendothelial matrix exhibits a distinctive organization, with collagen fibers beneath the endothelium oriented parallel to the flow and comprising mainly types III and I collagen in arteries and arterioles. However, the significance of such organization in initiating thrombus formation remains unclear.To investigate ... |
41885041 | Molecular dynamics insights into orientation and hexagonal ordering of tripodal triptycenes on solid surfaces. | Triptycene derivatives bearing long alkoxy chains at the 1,8,13- or 1,8-positions have been demonstrated to self-assemble on solid substrates into highly ordered thin films featuring a two-dimensional (2D) nested hexagonal packing of the triptycene moieties and a one-dimensional (1D) stacking layer. Although the bulk-p... |
41870382 | MOF-on-MOF NiFe-BDC@ZIF-67 heterostructure nanoarrays for chloride-suppressed oxygen evolution in alkaline seawater. | A NiFe-BDC/ZIF-67 heterostructure is constructed as an efficient electrocatalyst for the oxygen evolution reaction (OER). Its high activity and chloride tolerance in alkaline seawater result from the interfacial synergy and the formation of a protective (oxy)hydroxide layer. This work presents a practical strategy for ... |
42006733 | Illuminating the metabolic sink: Optical probes for in vivo thermogenic fat imaging. | As a metabolic sink, thermogenic fat plays a pivotal role in the pathogenesis of metabolic diseases, yet current techniques for assessing its location and activity in vivo face challenges, such as high costs and operational complexity. Optical imaging, encompassing label-free and labeled modalities, offers a relatively... |
42006642 | Trypsin-functionalized Ag-Au nanoflowers for enhanced sensing of hydrogen sulfide in diverse foods: dual mechanisms of steric hindrance-mediated biothiols exclusion and silver-driven 30-fold cascade amplification. | Combining the excellent optical properties, spatial structure specificity and 30-fold cascade signal amplification strategy of the trypsin-stabilized silver‑gold nanoflowers (Try-AgAuNFs), a novel nanosensing system was constructed for improving the sensing of hydrogen sulfide (H<sub>2</sub>S). It is worth noting that ... |
42002353 | Polysaccharide-based microgels as carriers for functional food ingredients: Fabrication, functional properties, mechanisms, and applications. | Functional food ingredients are prone to poor stability and low bioavailability during processing, storage, and digestion, which limits their functional efficacy and thus drives the development of efficient delivery carriers. By regulating the molecular structure of polysaccharides (including glycosidic bonds, degree o... |
41990401 | Co-engineering crystallographic and topological exposures of Zeolitic Imidazolate framework toward superior sulfur redox kinetics in Lithium-sulfur batteries. | Rationally engineered metal-organic frameworks (MOFs) hold significant promise for addressing the shuttle effect and sluggish kinetics in lithium‑sulfur (LiS) batteries. Here, we develop zeolitic imidazolate framework (ZIF-7) with distinct crystallographic phases and topological morphologies to investigate the structur... |
41977484 | AI-Assisted Molecular Biosensors: Design Strategies for Wearable and Real-Time Monitoring. | Artificial intelligence (AI) has become a transformative tool in the field of molecular biosensing, enabling data-driven optimization in sensor design, signal processing, and real-time monitoring. AI promotes the discovery of biomarkers, the design of high-affinity receptors, and the rational engineering of sensing mat... |
41976544 | Advances of Digital Detection for Foodborne Pathogens. | The implementation of stringent regulatory policies for foodborne pathogens necessitates ultra-sensitive analytical methods. Digital detection, characterized by absolute quantification and tolerance to complex matrices, serves as a robust approach for food safety monitoring. This review summarizes recent advances in di... |
41967445 | Cellulose nanocrystal stabilised Pickering emulgels for sustained colonic delivery of budesonide. | Inflammatory Bowel Disease (IBD) is a chronic gastrointestinal condition that could benefit from targeted drug delivery strategies to minimise systemic side effects. Conventional therapies often lack site specificity, limiting their effectiveness. Here, emulgels stabilised by cellulose nanocrystals (CNC) and reinforced... |
41962221 | On-site unlocking and local detonation: A programmed death ligand 1-targeted nanoplatform achieving precise immune activation to convert cold Tumors into hot Tumors. | Immunotherapy represents a pioneering approach in clinical cancer treatment, but its application is often limited by insufficient immune stimulation and off-target side effects. Therefore, developing novel nanomaterials capable of precisely reshaping the tumor microenvironment (TME) is crucial for enhancing the efficac... |
41962218 | Integrated pressure and torsion sensor with porous graphene aerogel electrodes embedded by conductive CuCo-MOFs. | With rod-like conductive CuCo-MOF embedded into three-dimensional porous graphene aerogel, a facial sense electrode is developed and applied in integrated pressure and torsion sensing application. In the composite aerogel, the embedded MOF nanorods expand interlayer spacing and form C-C bonding networks with graphene s... |
41953640 | Lycorine Derivative Inhibits SARS-CoV-2 Replication by Reducing -1 Programmed Ribosomal Frameshifting via Targeting ZAP. | The ongoing evolution of SARS-CoV-2 and its immune-evading variants underscores an urgent requirement for broad-spectrum antiviral drugs. In this study, a series of lycorine derivatives was synthesized. This led to the identification of compound <b>7</b> as a promising antiviral candidate. Compound <b>7</b> exhibited p... |
41951085 | Chitosan/oxidized sodium alginate double-network hydrogel incorporated with Zn-BTC: leveraging MOF-polymer interaction mechanisms for enhanced mechanical properties and sustained antibacterial activity. | Conventional wound dressings struggle to conform to wounds located near stretchable body surfaces due to frequent skin movement and stretching. Furthermore, wounds in motion areas are often complicated by persistent infections. To meet these demands, we propose a novel CS/OSA/ZnBTC hydrogel by incorporating Zn-BTC (BTC... |
41951042 | A scalable microfluidic-blow-spinning platform for fabricating food-grade γ-cyclodextrin metal-organic-framework nanofiber composites with sustained release of thymol: a preservation case study of fresh-cut fruits. | <h4>Introduction</h4>Developing advanced functional composites by integrating metal-organic frameworks (MOFs) with polymeric nanofibers are important research in materials science. This strategy of incorporating MOFs into polymeric nanofibers offers a promising route to fabricate multifunctional materials with controll... |
41951034 | Addressing delivery and resistance issues of CDK4/6 inhibitors as cancer therapeutics. | Cancer treatment is limited by poor specificity, efficacy, toxicity and resistance associated with conventional treatment options involving surgery, chemotherapy, and radiation therapy. The introduction of newer targeted agents, such as cyclin-dependent kinases-4 and -6 (CDK4/6) inhibitors, in the treatment of hormone ... |
41950887 | Zwitterionic peptide dendrimer-based nanocarriers with enhanced stability and biocompatibility for cancer therapy. | Autophagy is a cellular self-degradation process that plays a dual role in cancer. Its mild activation can promote tumor survival, while its excessive activation may lead to autophagy-related cell death. Therefore, synergistic treatment of chemotherapeutic agents and autophagy inducers could be a potential strategy to ... |
41944120 | Methyl-β-Cyclodextrin Enhances the Chemotherapeutic Efficacy of Paclitaxel in Breast Cancer Cells. | <h4>Background</h4>Chemoresistance, a long-standing clinical challenge in breast cancer treatment, continues to affect chemotherapy outcomes. Cholesterol-enriched lipid rafts are increasingly recognized as key mediators of drug efflux, primarily via transporters like P-glycoprotein (P-gp). Therefore, targeting lipid ra... |
41943233 | Semiconductive MOF-Based Supercapacitor Diodes. | The supercapacitor-diode (CAPode), which integrates ionic and electronic transport within a single system, holds promise for efficient communication between biological systems and electronic devices, thereby showing significant potential in the next generation of human-machine interaction. However, the operating princi... |
41942575 | Methane diffusion path in HKUST-1 metal-organic framework revealed by atomistic simulations. | A copper-based metal-organic framework (MOF) HKUST-1 exhibits high methane adsorption capacity, primarily due to strong Coulomb interactions near open metal sites (OMSs) and van der Waals interactions within ligand-enclosed cavities. While the adsorption sites have been widely studied, the diffusion pathways through wh... |
41942314 | Quantum Coherence in a Perylene-Based Metal-Organic Framework for Potential Solid-State Qubits. | Metal-organic frameworks (MOFs) have emerged as promising candidates for quantum information and photonic applications due to their structural tunability and the potential to contain molecular qubits in architectures that support coherent light-matter interactions. In this study, we investigate the ultrafast coherent d... |
41942094 | Model Peptides Enable Comparisons of Substrate Binding Modes of Hsp70 Molecular Chaperones. | Hsp70 molecular chaperones play a wide array of essential roles in the cell by exploiting their ability to bind incompletely folded client proteins. Our past study of the <i>Escherichia coli</i> Hsp70, DnaK, bound to short peptides revealed many details of the interaction between a model substrate and the "pockets" of ... |
41942073 | H···X Hydrogen Bonds Govern Chain Geometry, Thermal Expansion, and Phase Behavior in Crown-Ether-Based Lead Halide Hybrids. | Hydrogen bonding is a central and versatile noncovalent interaction across nature and synthetic materials. However, a fundamental understanding of how specific hydrogen-bonding motifs dictate crystal structure and macroscopic properties remains limited. In this work, we demonstrate that H···X (X = halide) hydrogen bond... |
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