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41931200 | Design and characterization of Zn-integrated cellulose nanoparticle derived from sugarcane bagasse for biomedical applications. | The valorization of agricultural residues for synthesizing advanced nanomaterials has garnered significant attention in recent years. This study reports the environmentally benign and cost-effective extraction of cellulose from sugarcane bagasse (SCB), a prevalent agro-industrial byproduct for the synthesis of nanopart... |
41931206 | A Review of CO<sub>2</sub> Electroreduction to Ethanol: C-C Coupling Mechanistic Insights and Catalyst Design. | As a major contributor to climate change, CO<sub>2</sub> has imposed severe detrimental effects on global ecosystems. Among various CO<sub>2</sub> conversion strategies, the electrocatalytic CO<sub>2</sub> reduction reaction (eCO<sub>2</sub>RR) stands out due to its ability to operate under mild conditions using renewa... |
41931112 | Discovery of Autophagy Modulators that Increase I1061T NPC1 Expression and Promote Cholesterol Efflux in Niemann-Pick Type C Patient-Derived Fibroblasts. | Autophagy, an evolutionarily conserved catabolic process, has been implicated as a potential therapeutic target in Niemann-Pick Type C (NPC) disease, a fatal lysosomal storage disorder. Our goal was to identify autophagy modulators that positively impact NPC-relevant phenotypes to further evaluate the role of autophagy... |
41931031 | A Graphene-Templated Epitaxial SnO<sub>2</sub>/FDM-23 Ternary Composite for Rapid and Highly Sensitive Hydrogen Sulfide Detection. | Achieving precise and real-time detection of trace hydrogen sulfide (H<sub>2</sub>S) and its related malodorous substances is essential for advancing a proactive prevention-oriented environmental governance model. However, metal-oxide-based H<sub>2</sub>S sensors often suffer from high operating temperatures, inadequat... |
41930960 | Hijacking competitor-derived signals: RcsB/C drives <i>Lysobacter enzymogenes</i> to exploit farnesol for enhanced antifungal capacity. | Microbial antagonism is a fundamental ecological process that shapes community composition and maintains ecosystem balance. However, the molecular signals, such as cross-kingdom interactions between bacteria and fungi in natural environments, remain largely unexplored. <i>Lysobacter enzymogenes</i> is a widespread pred... |
41930562 | Targeting pyroptosis to treat aortic aneurysms: From mechanism to drug discovery (Review). | Pyroptosis is a lytic and highly inflammatory type of programmed cell death that is mediated primarily by members of the gasdermin (GSDM) protein family. Upon activation by inflammatory stimuli or danger signals, GSDMs are cleaved to release N‑terminal fragments that oligomerize and form pores in the plasma membrane. T... |
41930559 | Decoupling the Effect of Crystal Morphology and Pore Microenvironment in Metal-Organic Frameworks for High-Resolution Separation. | Crystal morphology and pore microenvironment in metal-organic frameworks (MOFs) are intrinsically coupled factors governing separation resolution in gas chromatography (GC), yet their individual roles remain difficult to disentangle. Here, using PCN-608 as a model system, we systematically decoupled the effects of crys... |
41930467 | Multiscale Molecular Modeling to Reveal Interactions between the Atomic Force Microscopy Tip and Lipid Bilayer Stacks. | Knowledge of AFM tip and lipid bilayer stack interactions is essential for designing and developing nano- to mesoscale lipid constructs. In this study, a model was developed to reveal the complex molecular mechanism governing tip-lipid interactions. This complexity in the interaction forces during penetration leading t... |
41928674 | Molecular Engineered Supramolecular Systems: Advancing Bioimaging and Precision Diagnostics. | Supramolecular systems have emerged as promising platforms for bioimaging and disease diagnostics driven by the growing demand for precision medicine and molecular diagnostics. Owing to their programmable molecular recognition, dynamic reversibility, and environmental responsiveness, these systems enable selective capt... |
41928673 | A Pillar[5]Arene-Based Supramolecular Nanoplatform With Dual Stimuli-Responsiveness for Targeted and Traceable Cancer Chemotherapy. | The development of a functionalized nanodrug delivery system (NDDS) represents a critical strategy in cancer diagnosis and therapy; however, smart materials capable of simultaneously tracking drug uptake and enabling targeted therapeutic intervention remain urgently needed. Herein, we designed a supramolecular NDDS, WP... |
41928663 | Simple Guanosine-Amino Acid Hybrids as Low Molecular Weight Hydrogelators. | While amino acids and nucleosides are the building blocks of molecular biology, very little is known about the behavior of simple hybrids consisting of a combination of these units. Here, we report the synthesis and self-assembly of derivatives obtained by covalently linking guanosine (G) and amino acids (Gly and Ala).... |
41928654 | An Ultra-Stable Cr-Hydroxamate Metal-Organic Framework From Postsynthetic Transmetalation. | Hydroxamate-based metal-organic frameworks (MOFs) have attracted increasing interest due to their strong chelating ability and inherent chemical robustness; however, their stability has yet to rival that of conventional carboxylate-based MOFs. Herein, using a tris-hydroxamic acid linker (H<sub>3</sub>TATPHA), we report... |
41928368 | MaHSFA2c modulates high temperature-inhibited chlorophyll breakdown in banana fruit by directly inducing the transcription of the E3 ligase gene MaBAH1. | Bananas (Musa acuminata, AAA group) ripening at temperatures higher than 24 °C prevent yellow skin development, resulting in green ripening, and significantly affecting the commercial potential of the fruit. Our recent study discovered that high temperature (HT) triggers the E3 ubiquitin ligase MaBAH1 to degrade MaMYB6... |
42007257 | Methodological innovations in perfusable vascular networks: Advancing high-density tissue models. | The development of physiologically relevant in vitro tissue models has long been constrained by the absence of a perfusable vasculature. Native organs and tumors are sustained not only by their cellular components but also by vascular networks that deliver oxygen and nutrients, remove waste, and mediate immune and phar... |
42007030 | The TcaR-CtsR regulatory cascade governs multi-stress tolerance and biofilm formation in foodborne <i>Staphylococcus</i> <i>aureus</i>. | <i>Staphylococcus aureus</i> exhibits remarkable resilience to environmental stresses, largely governed by complex transcriptional regulatory networks. While CtsR is a well-established repressor of the heat shock response in Gram-positive bacteria, its role in <i>S. aureus</i> extends beyond proteotoxic stress manageme... |
42006637 | One-step synthesis of a Tb-PET MOF for quantitative visual sensing of Anthrax biomarker. | Novel strategies for the sensitive and rapid detection of the anthrax biomarker (2,6-pyridinedicarboxylic acid, DPA) are critical for ensuring food safety and preventing the disease. In this study, a novel fluorescent metal-organic framework (MOF) was fabricated via a directly from waste polyethylene terephthalate (PET... |
42006470 | Orthogonal cation and anion template-directed synthesis of a heteroditopic [3]catenane for ion-pair recognition. | The first orthogonal template strategy for the synthesis of higher order interlocked structures is described. Orthogonal cation and anion templates were employed in a stepwise fashion to construct a hetero[3]catenane composed of structurally distinct macrocyclic components. Importantly, the [3]catenane contains two int... |
42004324 | Monte Carlo Approach for Liquid-Phase Adsorption of Drugs in Metal-Organic Frameworks. | Metal-organic frameworks (MOFs) have attracted attention as drug carriers in drug-delivery systems (DDSs). MOFs, which are composed of metal ions and organic linkers, exhibit high porosity, tunable pore structures, and large surface areas, making them promising DDS carriers. Molecular simulation methods are powerful to... |
42003935 | Lactylation enzymes in cancer: Mechanisms and novel therapeutic approaches (Review). | Metabolic reprogramming, particularly the Warburg effect, drives tumor progression not only by supplying energy but also by reshaping the epigenetic landscape through lysine lactylation. The present review summarizes the molecular organization of the lactylation regulatory network, highlighting two distinct writer mech... |
41993878 | Conservation of Bacterial Lipopolysaccharide Binding by SARS-CoV-2 Spike across Major Viral Variants. | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis is shaped not only by viral entry mechanisms but also by interactions with host and microbial factors. The viral spike (S) protein can bind Gram-negative bacterial lipopolysaccharide (LPS), a driver of hyperinflammation in severe COVID-19. How vi... |
41988496 | ProCharTS <sup><i>PTM</i></sup> label-free optical detection of protein acetylation using UV-vis charge transfer spectra. | We report the first spectroscopic detection of protein acetylation in solution using UV-vis Protein Charge Transfer Spectra (ProCharTS). Acetylation is an important post-translational modification (PTM) that modulates diverse cellular processes, yet its detection relies on antibody-based cost-intensive and/or destructi... |
41982918 | Machine learning potential for modelling dynamic hydrogen bond networks in MOF MIL-120. | Metal-organic frameworks (MOFs) are porous materials with the potential for gas adsorption and separation technologies due to their tunable structural and chemical characteristics. However, simulating gas adsorption isotherms in MOFs with DFT-level accuracy remains a key challenge. In this work, we use MIL-120 as a cas... |
41978612 | Product distribution in the silicatein-catalysed synthesis of polydimethylsiloxane. | Biocatalytic polymerisations of monomeric siloxane precursors to polysiloxane "silicone" polymers were recently reported. This study further investigates the polymerisation and depolymerisation of poly(dimethylsiloxane) from the monomeric precursor dimethyldimethoxysilane, catalysed by recombinant enzyme silicatein-α. ... |
41977751 | Functional Characterization of <i>VvSR34a</i> Gene from Grapevine in Response to Salt Stress. | Salt stress severely restricts grape (<i>Vitis vinifera</i> L.) production. Serine/arginine-rich (SR) proteins, as a class of RNA-binding proteins, play important roles in plant growth, development and stress responses. However, the function and regulatory mechanism of <i>VvSR34a</i> in grape salt tolerance remain uncl... |
41977627 | Fine-Tuning Directional Message Passing Neural Networks: Predicting Properties of Conjugated Organic Polymers with High Accuracy. | Conjugated organic polymers are the cornerstone of modern organic electronics, yet accurate prediction of their properties remains a challenging task due to their synthetic complexity and high computational cost of quantum-chemical methods. Here, we develop a graph neural network based on the DimeNet++ direct message p... |
41977626 | Amino-MIL-101(Fe)/Chitosan-Graphene Oxide Cross-Linked Nanocomposite for High-Performance Adsorptive Remediation of Wastewater Microplastics from Environmental Samples. | One of the main sources of microplastic pollution in aquatic ecosystems is municipal wastewater, and preserving the ecological security of water depends on its effective removal. In this study, a potential multi-functionalized nanocomposite (NH<sub>2</sub>-MIL-101(Fe)/CS/GO), which consists of an iron-based metal-organ... |
41977419 | An Evaluation of the Interaction of Brefeldin A with Mitogen-Activated Protein Kinase 1 (MAPK1) and Protein Kinase C Alpha (PrKCα): Insights from Molecular Modelling Studies. | Aberrant protein glycosylation is a key driver of colorectal cancer (CRC) progression, contributing to tumour growth, metastasis, and immune evasion. In this study, computational approaches were employed to explore the potential of Brefeldin A as an inhibitor of two glycosylation-associated regulatory proteins: Protein... |
41976710 | Hierarchical NiCo<sub>2</sub>O<sub>4</sub>/NiCoS Nanoarrays for Improved Electrochemical Performance. | The NiCo<sub>2</sub>O<sub>4</sub>/nickel cobalt sulfide (NiCoS) electrode was constructed on a nickel foam (NF) substrate using a combination of hydrothermal synthesis and constant potential electrodeposition. The NiCo<sub>2</sub>O<sub>4</sub> prepared via an in situ hydrothermal method followed by calcination served a... |
41976506 | Phytochemical Diversity, Mechanistic Pharmacology, and Therapeutic Potential of <i>Alpinia oxyphylla</i>. | <i>Alpinia oxyphylla</i> Miquel is a perennial medicinal plant widely cultivated in the provinces of Fujian, Guangdong, and Hainan in China. The dried mature fruit of <i>A. oxyphylla</i>, officially recorded as Alpiniae Oxyphyllae Fructus in the pharmacopoeia of the People's Republic of China (since 2012), is one of th... |
41976219 | Computational Study of Linker Polarity Effects on Optical Electron Transfer in Imine- and Acylhydrazone-Linked Covalent Organic Frameworks Using Fragment Models. | Covalent organic frameworks (COFs) have become a research hotspot in photocatalytic materials in recent years due to their highly ordered structures, tunable topologies, and excellent optoelectronic properties. However, the relationship between linker polarity and the direction of optical electron transfer between adja... |
41976220 | Antibody-Drug Conjugates (ADCs): A Review of Structural Design, Technological Evolution, and Future Perspectives. | Antibody-drug conjugates (ADCs) have become an important class of targeted anticancer therapeutics by integrating the tumor selectivity of monoclonal antibodies with the potent cytotoxicity of small-molecule payloads through rational linker design. This review summarizes the structural fundamentals of ADCs, including a... |
41976225 | Selective Enrichment of Antibacterial Peptides from Chicken Hemoglobin Hydrolysates by Electrodialysis with Ultrafiltration Membranes (EDUF). | Chicken hemoglobin represents a source of bioactive peptides that could replace synthetic additives. This study evaluated the antibacterial and antifungal potential of chicken hemoglobin hydrolysates and the effect of their fractionation by EDUF. Hemoglobin was hydrolyzed with pepsin at pH 3 for 0.5 h and 6 h, followed... |
41976217 | Review of Structural Modification and Development of Novel Tramadol Derivatives. | Tramadol acts via μ-opioid receptor agonism and monoamine reuptake inhibition but is clinically limited by metabolic dependence, interindividual variability, and addiction risks. Structural modification aims to resolve these limitations. This review systematically summarizes tramadol's structure-activity relationships ... |
41972733 | Adenine Nucleotide Translocase: From Nucleotide Carrier to a Modulator of Mitochondrial Bioenergetics, Quality Control, and Cellular Communication. | Adenine nucleotide translocase (ANT) has traditionally been defined as the ADP/ATP exchanger of the inner mitochondrial membrane. However, accumulating mechanistic evidence reveals a substantially broader functional spectrum that extends beyond nucleotide transport. In this review, we integrate these advances into a un... |
41972577 | Decoding Drug Resistance in Pancreatic Cancer: A Subcellular Structure Perspective. | Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with drug resistance representing the primary barrier to effective treatment. Current research has largely focused on individual signaling pathways or isolated organelle functions, yet a comprehensive understanding of how these subcell... |
41946335 | Laccase- and peroxidase-like synergy-driven Cu-MOF nanozyme sensor array for high-throughput screening of phenolic pollutants. | Phenols are widespread high-risk environmental contaminants that exhibit structural diversity and vary in toxicity and environmental risk with substituent changes. Therefore, efficient methods for screening multiple phenols are urgently needed. Here, two nanozymes (Cu-MB and Cu-TB) with dual laccase-like and peroxidase... |
41940261 | Research advances in intelligent microenvironment-responsive hydrogels for myocardial infarction therapy. | Myocardial infarction (MI) poses a severe threat to human life and health. During acute MI, persistent myocardial ischemia and hypoxia induce pathological alterations in the microenvironment. Traditional therapeutic approaches exhibit limited capacity for targeted modulation of this infarcted microenvironment. Conseque... |
41938162 | β-cyclodextrin-functionalized acetylene black nanocomposite electrode with enhanced host-guest enrichment for ultralow-level detection of niclosamide. | Accurate electrochemical quantification of niclosamide (NA) remains challenging due to its limited aqueous solubility, sluggish electron-transfer kinetics, and the inherently complex multi-electron nitro-reduction pathway. In this work, a β-cyclodextrin/acetylene black composite electrode (β-CD@AB/GCE) is developed to ... |
41938164 | Development of a molecularly imprinted electrochemical sensor based on (Cu-BTC)-MOF and graphene composite for highly sensitive and selective chloramphenicol detection. | A highly selective molecularly imprinted electrochemical sensor was constructed for chloramphenicol (CAP) detection based on a copper-benzenetricarboxylic acid metal-organic framework (Cu-BTC)-MOF)/graphene (Gr) composite and poly(<i>o</i>-phenylenediamine) (<i>o</i>-PD) molecularly imprinted polymer (MIP). The (Cu-BTC... |
41938165 | Regioselective green synthesis of some novel indole-substituted 1<i>H</i>-benzo[<i>f</i>]chromenes <i>via</i> one-pot three-component reactions in water-ethanol media. | A regioselective, efficient and environmentally friendly method was developed for the synthesis of novel indole-substituted 1<i>H</i>-benzo[<i>f</i>]chromene derivatives through one-pot multicomponent condensation reaction of 3-cyanoacetyl indole, 2,7-dihydroxynaphthalene, and various aryl, heteroaryl and aliphatic ald... |
41938163 | Sulfone-quinone derivatives: a review on their synthetic methods, properties and applications. | This review presents seven synthetic approaches for sulfone compounds and two for quinone compounds, along with a discussion on their physical and chemical properties and reactivities with various organic compounds. It also highlights several notable applications of these derivatives, particularly in the biological and... |
41933970 | Can nanozymes make the leap to the clinic? Advances, hurdles, and prospects. | Nanozymes (enzyme-like catalytic nanomaterials) represent a new generation of artificial enzymes designed to overcome key limitations of their natural counterparts, including high production costs, low stability, and challenging storage requirements. Their versatility spans biosensing, bioimaging, therapeutics, and env... |
41932244 | A target-triggered cascade colorimetric biosensor based on PCN-222(Fe)/GOx nanozyme for rapid detection of antibiotic resistance genes. | The widespread dissemination of antibiotic resistance genes (ARGs) in the environment poses a serious threat to public health. Herein, we develop a cascade colorimetric biosensor based on a PCN-222(Fe) metal-organic framework nanozyme and glucose oxidase (GOx) for the sensitive detection of ARGs. Encapsulation of GOx w... |
41932203 | Migrasome-mediated clearance of excess PLK4 defines a targetable vulnerability. | <h4>Background</h4>Centrosome amplification caused by Polo-like kinase 4 (PLK4) overexpression promotes tumour initiation, yet sustained PLK4 accumulation is detrimental to cancer cell viability. While proteasomal degradation limits PLK4 levels, whether alternative clearance mechanisms exist remains unknown.<h4>Methods... |
41928413 | 14-, 30-, and 56-Membered Azamacrocyclic Mannich Bases Built on Bispyrrolylphenylene Platforms: Isolation and Initial Anion Binding. | A hitherto unknown class of 14 (<b>3</b>)-, 30 (<b>5</b>)-, and 56-membered (<b>4</b>) azamacrocycles containing bispyrrolylphenylene moieties was synthesized via Mannich reactions and characterized by spectroscopic and crystallographic techniques. Among the observed [1 + 1 + 2], [2 + 2 + 4], [3 + 3 + 6], and [4 + 4 + ... |
41927708 | The effect of lateral π-extension on azulene-based molecules on surface studied by LT-STM. | Azulene-based systems offer a robust platform for exploring molecular self-assembly and electronic properties on surfaces due to their non-benzenoid topology and dipolar structure. Here, we report the low-temperature scanning tunnelling microscopy investigation of two structurally related azulene-based molecules, namel... |
41927466 | Dual-Shell Chitosan/Ferritin Nanocages Enhance the Stability, Intestinal Transport, and Antiviral Activity of EGCG against HBV. | Epigallocatechin gallate (EGCG) has shown antiviral potential against the hepatitis B virus (HBV) by restoring lysosomal acidification; however, its application is limited by poor stability and low intestinal permeability. Here, a dual-shell chitosan/ferritin nanosystem (CHE) was developed to enhance the EGCG delivery ... |
41926749 | Prion Protein-Derived Cell-Penetrating Peptide Inhibits Type II Diabetes-Associated Islet Amyloid Polypeptide Aggregation and Cytotoxicity. | Islet amyloid polypeptide (IAPP) is a 37-residue peptide hormone copackaged and cosecreted with insulin by pancreatic β-cells. A pathological hallmark of type II diabetes is the self-assembly of IAPP into β-sheet rich amyloid fibers, which is associated with β-cell impairment. Previously, we showed that a cell-penetrat... |
41926683 | Plasma-Driven Single-Atom Catalysis: From Synthesis to Catalytic Reactions. | The integration of nonthermal plasma (NTP) with single-atom catalysis has recently emerged as a highly promising yet largely unexplored frontier in heterogeneous catalysis. NTP generates highly nonequilibrium reaction environments rich in energetic electrons, radicals, and excited species, while single-atom catalysts (... |
41926663 | Construction of a MOF-Based Snap-Top Delivery Nanosystem for Powerful Dual-Responsive Synergistic Colitis Treatment. | Oral treatment of inflammatory bowel disease (IBD) faces significant challenges of poor targeting, low bioavailability, and systemic toxicity, necessitating intelligent stimuli-responsive delivery systems. Here, we design and synthesize a pH/hypoxia dual-responsive pendant azobenzene-functionalized MOF (Azo-MOF). The u... |
41926661 | Nickel Cluster-Based Organic Framework-Functionalized Solid-State Electrolyte for Lithium-Metal Batteries. | The low ionic conductivity (σ) and poor capacity retention severely hinder the further application of solid-state electrolytes (SSEs) in lithium-metal batteries (LMBs). Herein, novel trinuclear cluster-based metal-organic frameworks (MOFs) with rich cage cavities and characteristic functional group -OH have been synthe... |
41926636 | Combination of Phthalocyanine, Azulene and Porphyrin for High Performance Nonlinear Optical Materials. | Phthalocyanine and porphyrin derivatives have garnered extensive attention in nonlinear optics due to their large cyclic conjugation, tunable electronic structures, and excellent biocompatibility. In this work, polar azulene was employed to connect phthalocyanine and porphyrin to construct an asymmetric triadic structu... |
41926613 | Electrostatic Potential Complementarity for Thickness-Tolerant Cathode Interlayers in High-Efficiency Organic and Tandem Solar Cells. | Designing cathode interlayers (CILs) that simultaneously deliver high efficiency, operational stability, and broad thickness tolerance remains a critical challenge for organic solar cells (OSCs). Herein, trimesic acid (TMA) and phloroglucinol (PG), two small molecules featuring opposite central electrostatic potential ... |
41926553 | Divergent and programmable skeletal remodeling of complex macrocycles with a small method set. | The bioactivity of complex organic macrocycles can vary unpredictably with their three-dimensional structural contours. Here, we present a streamlined, programmable and systematic strategy for skeletal remodeling of large organic rings. The central diversification platform (hub) is a readily available macrocyclic olefi... |
41926452 | Specificity and recognition of the ADP-ribosyl-ubiquitin modification in the DNA damage response. | ADP-ribosylation (ADPr) is a post-translational modification that has regulatory roles in multiple cellular pathways including the DNA damage response and in innate immunity. Recently, it has been uncovered that ADP-ribose can be further modified by a family of ubiquitin E3 ligases, the DELTEXES, which catalyze ubiquit... |
41926391 | Functionalized calcium carbonate microparticles in ethyl cellulose films: A vehicle for sustained amoxicillin release for medical applications. | The continuous quest for materials capable of providing sustained release of antimicrobial drugs is particularly important for indwelling medical applications. In this study, we utilized amoxicillin as a model active pharmaceutical ingredient (API) to investigate the feasibility of using porous media - specifically, fu... |
41926351 | Development of a New Type of Magneto-optical Material: Flexible, Low-Cost, Fe<sub>3</sub>O<sub>4</sub>@ZIF-8/PgC<sub>5</sub>Cu/PMMA with High Figure of Merit. | Magneto-optical materials are essential for optical communication devices, yet most crystalline or vitreous media are rigid and have high demands on design and processing. Here we develop a facile multicomponent composite strategy to fabricate a flexible magneto-optical film, Fe<sub>3</sub>O<sub>4</sub>@ZIF-8/PgC<sub>5... |
41926232 | Heterogeneity-Resolved Ultrafast Transient Absorption Spectroscopy of Single Supramolecular Light-Harvesting Antennas. | Photosynthetic light harvesting proceeds rapidly and robustly through precisely arranged pigment molecules. However, the molecular arrangements are not uniform because they exhibit structural heterogeneity among individual complexes and across spatial regions and undergo dynamic fluctuations. Such static and dynamic di... |
41926231 | When Matter Builds Itself: Blueprints from Life to Materials. | Self-assembly is pervasive in living systems but remains an unconventional paradigm for constructing functional materials in biological environments. Rather than relying on ex situ fabrication and subsequent integration, in situ self-assembly enables the autonomous formation of supramolecular architectures under physio... |
41926099 | Protein-protein interfaces in chemotaxis receptor complexes and their role in signaling. | Chemotaxis receptor complexes sense chemical gradient in the cellular environment to direct swimming towards favorable environments. The core signaling units of these complexes are made up of two trimers-of-dimers of chemoreceptors, two CheW and a CheA dimer, which further assemble into large hexagonal signaling arrays... |
41925951 | Alzheimer's disease: from molecular pathways to therapies. | Alzheimer disease (AD) is the most common neurodegenerative disorder and a leading cause of dementia worldwide. With accelerating population aging, its incidence continues to rise, imposing a substantial burden on public health systems and society. Despite extensive advances in research, currently available therapies r... |
41925899 | Research progress on nucleic acid amplification-based detection technologies for phytopathogenic fungi. | Phytopathogenic fungi are highly diverse and globally distributed, posing a major threat to agricultural production worldwide. The annual losses caused by plant diseases can reach up to 30% of global crop yields, with over 80% of infections caused by fungal pathogens. The accurate identification of pathogenic fungal sp... |
41925842 | Achieving White Circularly Polarized Luminescence via One-Pot Encapsulation of Dyes in Chiral MOFs. | Developing robust materials that exhibit full-color, switchable, circularly polarized luminescence (CPL) remains a significant challenge. Herein, we report a facile, one-pot encapsulation of achiral dyes within chiral metal-organic frameworks (MOFs) for tunable CPL emission. This approach leverages the chiral microenvi... |
41925825 | Wavelet-Enhanced Data-Driven Collective Variables for Efficient Sampling of Protein Folding Landscapes. | The development of collective variables (CVs) capable of distinguishing important (meta)stable states and describing slow degrees of freedom (DOFs) is widely recognized as a prerequisite for the success of CV-based enhanced sampling methods, particularly in biomolecular systems where the underlying free-energy landscap... |
41925762 | Gas-Solid Reaction to Rapidly Construct Chiral MOFs for Efficient Enantioselective Sensing. | The efficient integration of chiral building blocks into metal-organic frameworks (MOFs) is critical for advancing both the streamlined synthesis of chiral MOFs and enantioselective applications in various fields. Herein, we report a gas-solid reaction to achieve rapid synthesis of hierarchically chiral MOFs, CMOF-T an... |
41925678 | A Bambusuril That Responds to Anion Binding in Its Absorption Spectrum. | We report the design, synthesis, and characterization of <b>BU1</b>, the first bambusuril derivative bearing phenyl substituents directly attached to the glycoluril nitrogen atoms. The macrocycle <b>BU1</b>, decorated with <i>p</i>-nitrophenyl groups, exhibits distinct optical responses upon anion binding, enabling the... |
41925630 | Ordered Proton Transport Channels in a Layered Host-Guest Crystal for High-Performance Fuel Cells. | Developing solid electrolytes with high intrinsic proton conductivity over a broad temperature range is crucial for proton exchange membrane fuel cells. We report a new layered cadmium chlorophosphate crystal, (C<sub>3</sub>N<sub>2</sub>H<sub>5</sub>)[CdCl(H<sub>3/2</sub>PO<sub>4</sub>)]<sub>2</sub> (CdClPO<sub>4</sub>... |
41925580 | Dynamic interfaces in metal-organic frameworks. | The dynamic interfacial behavior of metal-organic frameworks (MOFs) lies at the heart of their structural adaptability and functional responsiveness. This review systematically summarizes the dynamic characteristics and regulation mechanisms of three types of interfaces in MOFs, including inorganic secondary building u... |
41925250 | Glycan pairing in therapeutic IgG orchestrates Fcγ receptor engagement and ADCC: an integrated structure-function approach for thorough evaluation of Fc N-glycans as critical quality attributes. | Monoclonal antibodies (mAbs) can mediate their therapeutic activity through antigen binding and by engaging Fc receptors (FcRs) or the complement system. FcRs are expressed on immune cells and can initiate effector functions such as antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocy... |
41925247 | Serum albumin and the Prognostic Nutritional Index independently predict fracture risk in elderly women. | Serum albumin and the Prognostic Nutritional Index (PNI), based on albumin and lymphocytes, are markers of nutritional and inflammatory status and have been associated with frailty and adverse outcomes in older adults. However, their relationship with fracture risk and underlying mechanisms remains unclear. In this pro... |
41925137 | Hydrogen-Bond Ionic Conductive Gel Lubricant with Integrated Thixotropy, Lubricity, and Electrotunable Performances for Electrified Equipment. | Conductive lubricants are crucial to resolving the conflict between friction wear and signal transmission in electrically powered components. Here, the excellent conductivity of ionic liquids was used to design and prepare an ionic supramolecular gel lubricant. An ionic liquid and urea-based functional groups were comb... |
41925116 | [Ru(bpy)<sub>3</sub>]<sup>2+</sup>: The Ongoing Story of a Photochemical Icon. | [Ru(bpy)<sub>3</sub>]<sup>2+</sup> has long served as the archetypal coordination complex for probing inorganic photophysics and photochemistry. Its intense visible MLCT absorption, quantitative intersystem crossing, and microsecond <sup>3</sup>MLCT lifetime established it as a benchmark photosensitizer across energy c... |
41925000 | Computational mechanisms of spin-influenced organic reactions catalyzed by 3d iron-group metals. | Different spin states of 3d iron-group transition metal complexes provide a transformative strategy that may overcome the limitations of conventional closed-shell catalytic systems. However, capturing highly reactive intermediates and elucidating their electronic structures like spin states encounter significant challe... |
41924996 | Ultrasensitive Cascade Enzyme Immunoassay Electrochemical Microfluidic Chip for Early Screening of Prostate Cancer. | Immunosensors offer great promise for cancer diagnostics owing to their high sensitivity, specificity, and potential for miniaturization. However, conventional electrochemical immunosensors often rely on single-step enzyme reactions and single-biomarker detection, limiting their signal amplification capacity and diagno... |
41924986 | Constructing White Fluorescence Supramolecular-Carbon Dots Hybrids with Room Temperature Phosphorescence for Efficient Light-Emitting Diodes. | White light-emitting diodes are gaining interest for next-generation lighting and displays due to their energy efficiency and wide applications. Conventional methods primarily combine a blue light-emitting diodes chip with a yellow emitter, or use an ultraviolet chip with red, green, and blue or white emitters. However... |
41924937 | Neutral-Condition Hydrogen Peroxide Electrosynthesis at Industrial-Level Current Density Over Bipyridine-Bridged Cobalt-Based Conductive Metal-Organic Frameworks. | Conductive metal-organic frameworks (c-MOFs) have been widely adopted for catalyzing two-electron oxygen reduction reaction (2e<sup>-</sup> ORR) toward hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) electrosynthesis, due to their precisely designable metal-nonmetal coordinations. However, the π-π conjugated c-MOFs norm... |
41924899 | Ionic Liquid-Driven Modulation of DNA Brush Morphology on Nanoparticle Surfaces. | The morphology of DNA is strongly influenced by its surrounding environment, including factors such as pH, salt type and valency, and the presence of polymers. Inorganic salts are known to reduce the DNA chain length through mechanisms like electrostatic screening and ion bridging. In contrast, ionic liquids, a new cla... |
41923661 | Cascaded Built-In Electric Fields Engineering for Electromagnetic Wave Absorption. | Built-in electric fields (BIEF) at heterointerfaces create non-equilibrium energy gradients that amplify dielectric response without sacrificing impedance matching, improving electromagnetic wave absorption (EWA). However, in cascaded BIEF systems formed by morphology control and multiphase hybridization, the impacts o... |
41860022 | From molecular tweezers to pliers: a significant enhancement of fullerene grasping capability. | A molecular design leap from simple tweezers to precision pliers is achieved by substituting planar bisporphyrins with curved calixarenes. A series of pH-responsive cavitand hybrids that reversibly switch between <i>vase</i> and <i>kite</i> conformations has been synthesized. Host-guest experiments demonstrated that th... |
41859861 | Small cavitand macrocycles from direct C-C coupling of <i>s</i>-aryl tetrazine units. | <i>s</i>-Aryltetrazine subunits are assembled into macrocyclic tri- and tetramers through carbon-carbon bond formation <i>via</i> Ullmann homocoupling of bromophenyltetrazines. Short aryl-tetrazine linkages generate compact, rigid macrocycles with small internal cavities, alongside noncyclised linear analogues. Structu... |
41853949 | Chiral bowl-shaped thiazole-embedded B(III)-azatriphyrins(2.1.1): a nonaromatic platform <i>via</i> triple core-modification. | We report the synthesis of a novel class of thiazole-embedded B(III)-monoazatriphyrin(2.1.1) macrocycles through a stepwise strategy that combines <i>meso</i>-nitrogen insertion, pyrrole-to-thiazole replacement, and an <i>ortho</i>-phenylene/naphthylene C<sub>2</sub><i>meso</i>-bridge. These macrocycles are nonaromatic... |
41848099 | Rational integration of fluorine and hydroxyl functionalities in UiO-66 metal-organic framework for enhanced propylene/propane separation. | Zr-based metal-organic framework UiO-66 is an attractive platform for hydrocarbon separations due to its exceptional chemical and thermal stability. We report a new UiO-66 derivative, UiO-66-F<sub>2</sub>(OH)<sub>2</sub>, integrating fluorine and hydroxyl groups into the framework. Compared to UiO-66-F<sub>4</sub> and ... |
41847983 | Eu-functionalized hydrogen-bonded organic frameworks as a ratiometric fluorescent sensor for highly sensitive detection of zearalenone. | Zearalenone (ZEA) is a toxic compound produced by fungal metabolism, which possesses mutagenicity, teratogenicity, carcinogenicity, nephrotoxicity, immunotoxicity, and genotoxicity, posing a serious potential threat to human and animal health. Therefore, establishing a rapid and accurate detection method for ZEA residu... |
41842749 | Bisbenzimidazoles with a benzenediyl spacer: an efficient fluorophore for dihydrogen phosphate sensing and targeted living cell imaging. | A bisbenzimidazole-based fluorescent probe (PBZ) has been developed for the selective detection of dihydrogen phosphate [H<sub>2</sub>PO<sub>4</sub>]<sup>-</sup> ions in a CH<sub>3</sub>CN-water (7 : 3, v/v) mixed solvent system. The probe exhibited pronounced spectral responses upon interaction with [H<sub>2</sub>PO<s... |
41778797 | Unlocking high-voltage sodium ion batteries with MOF-derived Cr<sub>2</sub>S<sub>3</sub>@C anode materials. | Extensive research on transition metal sulfide (TMS) materials highlights their potential as promising anode materials for sodium-ion batteries (SIBs). However, most TMS anodes exhibit average reaction potentials above 1.5 V <i>vs.</i> Na<sup>+</sup>/Na, resulting in full cell discharge plateaus below 2 V. Clearly, the... |
41773989 | The bis-salphen Zn(II) unit: a versatile building block for self-assembled heteroleptic coordination cages. | Heteroleptic coordination cages enable not only a high control over the cavity properties but also multifunctionality. However, their synthesis is far from trivial and often relies on precious 4d and 5d transition metals such as Pd(II). The transfer to more cost-effective, earth abundant metal ions such as Zn(II) is hi... |
41770107 | An amorphous MOF conversion strategy for membrane fabrication with a unique surface architecture. | We demonstrate an innovative amorphous-to-crystalline MOF transformation strategy that enables the fabrication of separation membranes with a distinctive surface architecture and domain structure not observed in conventional MOF membranes. This work highlights the utility of amorphous MOFs as versatile precursors and p... |
41766525 | Potassium-intervened copper-nickel bimetallic organic framework with a potassium hydrogen phthalate ligand for high-performance aqueous potassium-ion hybrid supercapacitors. | To develop high-performance electrode materials for aqueous potassium-ion hybrid supercapacitors (APICs), a bimetallic metal-organic framework (MOF), CuNi-KHP (KHP = potassium hydrogen phthalate), was prepared <i>via</i> a solvothermal method. The material features a 3D architecture constructed by stacking 2D nanosheet... |
41758198 | Process-dependent hypersonic phonon dispersion of brush particle metamaterials. | The self-assembly of polymer-grafted nanoparticles (PGN) has drawn interest as a platform approach for the fabrication of hybrid materials in which novel functionalities, such as photonic or phononic band gap formation, arise from the interplay of microstructure regularity and brush interactions. However, the complex d... |
41758048 | Advances in the construction and biological applications of DNA condensates. | Intracellular biomolecular condensates are membraneless liquid droplets formed by liquid-liquid phase separation (LLPS), which play essential roles in transcriptional control, stress responses, and cellular signaling. Inspired by these natural systems, DNA has emerged as the preferred molecule for constructing artifici... |
41757987 | Enhancing the electrocatalytic potential of trimetallic CeSmGd-MOFs for oxygen evolution reaction, supercapacitor, and dye degradation applications. | Developing multifunctional materials exhibiting high electrocatalytic activity, superior energy storage capability, and excellent pollutant degradation efficiency is highly desirable for advancing sustainable energy and environmental technologies. A novel approach to fabricate two different trimetallic metal-organic fr... |
42013233 | A Fluorogenic Biosensor for Direct Detection of Vibrio vulnificus, a Climate Change Biomarker. | Vibrio vulnificus, a marine pathogen and climate change biomarker, poses serious risks to human and animal health through seafood consumption and seawater exposure. Rapid detection methods are urgently needed for both vibriosis diagnosis and surveillance in warming coastal waters. We report a fluorogenic biosensor base... |
42012463 | The Critical Role of GALNTs-Regulated O-GalNAc Glycosylation in Cancer Malignancy. | Aberrant mucin-type O-glycosylation, mediated by the Polypeptide N-acetylgalactosaminyltransferase (GALNT) family of enzymes, is a defining feature of many cancers and has also been strongly linked to non-neoplastic conditions, including developmental disorders and metabolic abnormalities. Mucin-type O-GalNAc glycosyla... |
42011783 | The Alteromonas macleodii ribosome enables consecutive incorporation of bulky D-amino acids into peptides. | Genetic code reprogramming allows for ribosomal incorporation of exotic amino acids, such as d-α- and d-β-amino acids, into peptides. However, their incorporation efficiency remains much lower than that of canonical l-amino acids, making their multiple/consecutive incorporations difficult. The side chain of d-α-amino a... |
42011726 | Dissecting the Chemical and Thermal Stabilities of Tetrads in G-Quadruplexes to Derive a Structure-Activity Relation for a Thrombin-Binding DNA G-Quadruplex Aptamer. | Guanosine- and deoxyguanosine-rich nucleic acids can form G-quadruplex structures (G4) that are stabilized by guanine tetrads (G4 tetrads). G4s find numerous applications in biotechnology. Here, we study a so called thrombin-binding aptamer (TBA), developed by SELEX procedures, that adopts a G4 conformation and inhibit... |
42009529 | [Nanopore sequencing for RNA modification and splicing analysis in skeletal muscle]. | Alternative splicing and chemical modifications of RNA are key mechanisms of post-transcriptional regulation. By modulating RNA structure, localization, stability, translation, and protein expression levels and diversity, they significantly influence cell fate and biological processes. In muscle tissue, these mechanism... |
42009492 | Interfacial Enrichment and Demetallation of a Zinc Porphyrin in the Ionic Liquid [C<sub>4</sub>C<sub>1</sub>Im][PF<sub>6</sub>]. | Understanding and controlling the surface composition of metalloporphyrins in ionic liquids (ILs) is crucial for designing photoactive materials. Here, we investigate the interfacial behavior of zinc-didodecylporphyrin molecules (Zn-DDP) dissolved in the hydrophobic ionic liquid 1-butyl-3-methylimidazolium hexafluoroph... |
42009420 | Efficient monitoring of trace phthalate esters in environmental waters using multi-walled carbon nanotubes@Fe<sub>3</sub>O<sub>4</sub>@MIL-101(Fe) nanocomposites based on magnetic dispersive solid-phase extraction. | <h4>Background</h4>Phthalate acid esters (PAEs) are endocrine-disrupting contaminants that require reliable trace-level monitoring in environmental waters. Magnetic dispersive solid-phase extraction (MDSPE) offers a green sample-preparation approach, but its performance is often constrained by the limited adsorption ca... |
42008516 | Multiheterostructure Electrocatalyst Engineered by In Situ Growth of NiS<sub>2</sub>/ReS<sub>2</sub> Interface on 2D MOF-Derived CoS<sub>2</sub> Nanoarrays for Enhanced Electrocatalytic Water Splitting. | Developing bifunctional electrocatalysts in alkaline water splitting remains a significant challenge for hydrogen production. Herein, a novel hierarchical electrocatalyst by coupling rhenium disulfide/nickel sulfide heterostructure with the two-dimensional metal-organic framework-derived CoS<sub>2</sub> nanoarrays (CoS... |
42007803 | Oridonin-Loaded PDA@Gel@GO Nanocapsules Modulate NLRP3 and Epithelial Repair in Colitis. | Ulcerative colitis (UC) is a chronic inflammatory bowel disease marked by sustained mucosal inflammation and epithelial barrier dysfunction, closely associated with aberrant NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation. Targeted oral therapies that simultaneously suppress inflammat... |
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