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41941699 | Dual-Element Modulation of Cu Active Sites toward Enhanced C-C Coupling in CO<sub>2</sub> Electroreduction. | Electrochemical CO<sub>2</sub> reduction (eCO<sub>2</sub>R) on copper (Cu) offers a promising route for producing multicarbon (C<sub>2+</sub>) products but is limited by sluggish C-C coupling kinetics and competing hydrogen evolution. Here, we report a dual-element modulation strategy for directly engineering Cu active... |
41941439 | An Environmentally Resilient, Metal-Organic Framework-Armored CRISPR/Cas12a Sensing Reactor (ENCASE) for the Ultra-Stable and On-Site Detection of <i>Salmonella typhimurium</i> in the Food Supply Chain. | The development of reliable and field-deployable detection technologies of <i>Salmonella typhimurium</i> (<i>S. typhimurium</i>) throughout the food supply chain is crucial for the early warning and effective control of salmonellosis outbreaks. CRISPR-based biosensors offer excellent specificity, high sensitivity, and ... |
41941438 | The non-vesicular cholesterol transporter GRAMD1C is a pan-coronavirus antiviral target. | Coronaviruses (CoVs) rely heavily on host lipid metabolism for efficient replication, but the specific host pathways involved remain incompletely defined. Here, we identify the non-vesicular cholesterol transport protein GRAMD1C as a key host factor required for the replication of multiple coronaviruses across α, β, an... |
41941335 | Catalytic Enantioselective S<sub>N</sub>2'-Type Reaction for Axial Allene Chirality. | Optically active compounds are abundant in nature and are of fundamental interest for organic, medicinal, and material chemistry. Catalytic transformation of readily available racemic compounds into the same value-added enantiomeric products is one of the most efficient and cost-effective protocols. Herein, an S<sub>N<... |
41941290 | Unravelling the Tunable Near-Infrared-II Fluorescence from FDA-Approved Indocyanine Green via Supramolecular Complexation with Albumin. | Indocyanine green (ICG) is a clinically approved near-infrared (NIR) dye widely used in angiography and tumor imaging, yet its emission is primarily restricted to the NIR-I window. Although protein binding has been reported to enhance its NIR-II fluorescence, the supramolecular basis of this behavior remains insufficie... |
41941280 | Total Synthesis of Isoriccardin C and Isoriccardin D Based on a Hydroxyl-Directed Palladium-Catalyzed Intramolecular C-H Alkenylation. | A concise, nine-step total synthesis of isoriccardin C and isoriccardin D has been developed. The strategy centers on the sequential installation of the four aromatic rings of the backbone by using three key transformations: Suzuki coupling, Wittig olefination, and Ullmann coupling. The pivotal step is a palladium(II)-... |
41941211 | Electric Field Directed Structural Modulation and Nanoassembly of Peptide Hydrogels. | This study presents a novel approach to modulate peptide self-assembly, solubility, and functional properties by utilizing an electric field as an external stimulus. Three short, heterochiral tripeptides, P1, P2, and P3, were designed based on their ability to form hydrogels. We demonstrate that the structural and func... |
41941095 | Data-driven explainable artificial intelligence models for predicting CO<sub>2</sub> uptake in metal-organic frameworks. | This study presents a comprehensive data-driven framework for predicting and interpreting CO<sub>2</sub> uptake in metal-organic frameworks (MOFs) using advanced machine learning (ML) and explainable artificial intelligence (XAI) techniques. A curated dataset of 223 experimentally reported MOF samples, characterized by... |
41940996 | Combined computational and classical medicinal chemistry procedure to disclose novel pyrrole-based compounds as potential antituberculosis agents. | Tuberculosis (TB) remains a major global health challenge, worsened by the rise of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains. In this study, we employed a combined computational and medicinal chemistry approach to design, synthesize, and evaluate new pyrrole-based analogues of Sudoterb (1, ... |
41940950 | Experimental and Computational Simulation of the Prebiotic Peptide Bond Formation Driven by Wet-Dry Cycles and Gamma Ionizing Radiation: An Insight into Molecular Evolution. | The origin of life through prebiotic chemistry and molecular evolution processes is a significant and unresolved issue in science. A key part of this process is how simple molecules, such as amino acids, transition into functional polymers, like peptides, which can store information and facilitate reactions. During thi... |
41940907 | Bibliometric and visualized analysis of metal‒organic frameworks in bone tissue engineering and bone diseases. | <h4>Background</h4>Given their tunable structures, high porosity, and multifunctional therapeutic potential, metal-organic frameworks (MOFs) have emerged as versatile biomaterials for bone tissue engineering and bone-related diseases. Despite rapid research growth, a systematic and bone-specific bibliometric understand... |
41940895 | Two-Dimensional Cr(III)-Based Metal-Organic Framework with Ultrahigh Stability and Superprotonic Conductivity Enabled by Sulfonate Stereochemistry. | Proton-conducting two-dimensional metal-organic frameworks (2D MOFs) are attractive solid electrolytes for electrochemical technologies, yet simultaneously achieving superprotonic conductivity and robustness remains highly challenging. Here, we report TGU-80(Cr), a 2D Cr(III)-MOF synthesized via a solvent-free route en... |
41940635 | Electrostatic Potential Tuning-Driven Molecular Rotor Rotation in Isostructural Metal-Organic Frameworks for C<sub>3</sub>H<sub>6</sub>/C<sub>3</sub>H<sub>8</sub> Separation. | C<sub>3</sub> hydrocarbon separation is a core process for refining high-value-added petrochemical products. However, due to the remarkably similar physicochemical properties of these molecules, metal-organic frameworks (MOFs) typically encounter an inherent adsorption capacity-selectivity trade-off. The dynamic pore c... |
41940493 | Tuning Electron Delocalization via Protonation in a Cyanidometal-Bridged Trinuclear Ruthenium Complex. | A cyanidometal-bridged trinuclear ruthenium complex <i>trans</i>-[Cp*(dppe)RuCN-Ru(DMPZ)<sub>2</sub>Cl<sub>2</sub>-NCRu(dppe)Cp*] (<b>1</b>) (Cp* = 1,2,3,4,5-pentamethylcyclopentadienyl, dppe = 1,2-bis(diphenylphosphino)ethane, DMPZ = 2,6-dimethylpyrazine) and its one-, two-electrons-oxidized products <b>1</b><sup><b>+... |
41937750 | Exploring the Role of Hydrogen Bonding in Cyclodextrin─Naphthalenediimide Binding Orientation. | We report a systematic investigation of alkyl-substituted naphthalenediimide (NDI) derivatives and their host-guest interactions with α- and β-cyclodextrins, elucidating the role of hydrogen bonding in dictating the binding orientation of NDIs with α-CD and β-CD. Thermodynamic, spectroscopic, and computational analyses... |
41937730 | Dynamic Double Carbaporphyrin-Fused Nanographene: Facile Monolayer and Persistent Bilayer Switching. | Manipulating the dynamic processes of nanographenes, from conformational flipping to supramolecular dimerization, is essential for gaining precise control over their properties and functions. In this study, a nanographene with two fused carbaporphyrin units (<b>HBC2P</b>) was synthesized by introducing dipyrromethene u... |
41937715 | Sustainable Conversion of Plastic and Corrugated Paper into Ni@C Integrated N/S Dual-Doped Carbon Membranes for Accelerated Polysulfide Redox in Lithium Polysulfide Batteries. | Rechargeable systems based on sulfur cathodes have attracted considerable interest as promising candidates for advanced energy storage owing to their exceptionally large theoretical energy density. However, widespread implementation of these batteries is still hindered by several intrinsic challenges. In particular, so... |
41937695 | Stimuli-Responsive Silsesquioxane Nanozymes for Organocatalysis in Water and Prodrug Activation in Cells. | Synthetic nanozymes have emerged as promising alternatives to natural enzymes for catalytic and therapeutic applications, yet their limited stability, aqueous compatibility, and catalytic scope impede broader utilization. Here, we report a mild, one-step sol-gel synthesis that yields ultrasmall, water-stable octa-amino... |
41937569 | Hydration-Mediated Energy Landscapes Govern Rotational Flexibility in Membrane-Bound Annexin V Assemblies. | Interfacial water organization and dynamics govern protein stability and function across molecular to supramolecular scales. Annexin V (AnxA5), a membrane repair protein, forms 2D assemblies on lipid membranes, yet the hydration role in repair remains unexplored. Combining three-dimensional atomic force microscopy (3D-... |
41937541 | Modulation of Fructose Transfer Process for Promoting Apparent Isomerization Activity of Amylosucrase from <i>Bifidobacterium thermophilum</i>. | Amylosucrase catalyzes the synthesis of valuable carbohydrate products, including α-1,4 glucans and sucrose isomers, but controlling product distribution remains challenging. We engineered the +2 subsite of <i>Bifidobacterium thermophilum</i> amylosucrase through saturation mutagenesis at Gly374 to enhance product sele... |
41937217 | Adsorption performance and mechanism of modified rice hull biochar for lead and cadmium removal in single and competitive systems. | While adsorption in multi-metal systems is crucial for practical wastewater treatment, its efficacy and mechanisms remain insufficiently explored. This study investigates the adsorption performance and underlying mechanisms of Pb(II) and Cd(II) using modified rice hull biochar in single and binary solute systems. Bioch... |
41937168 | The updated requirements and functional roles of dietary protein and amino acids in ducks: a comprehensive review. | Waterfowl, primarily ducks, constitute a major commercial poultry species globally, their production efficiency is heavily influenced by dietary protein and amino acid intake. Although the National Research Council (NRC, Nutrient requirements of poultry, 1994) established fundamental recommendations for protein and ami... |
41919558 | In-situ gel systems for periodontitis: advances in localized drug delivery and regenerative therapy. | Periodontitis is a chronic inflammatory condition initiated by pathogenic microbial biofilms and exacerbated by host immune responses, leading to progressive connective tissue, alveolar bone destruction and eventual tooth loss. Conventional therapies such as scaling and root planning, systemic antibiotics and surgical ... |
42006670 | Mild thermal unfolding of pea protein enhances curcumin binding and interfacial properties of the resulting complexes. | This study investigated how thermal treatment (80-100 °C) alters the structure of pea protein isolate (PPI) and affects curcumin encapsulation and the interfacial properties of PPI-curcumin complexes. Heating induced progressive tertiary loosening, as shown by fluorescence red shifts, increased surface hydrophobicity, ... |
41977481 | Oral Delivery of Liraglutide Formulated with PLGA for Sustained Obesity Management. | Liraglutide (Lira), a glucagon-like peptide-1 (GLP-1) receptor agonist, has demonstrated substantial efficacy in improving glycemic control and reducing body weight. However, subcutaneous injection is poorly adherent for patients. To improve treatment compliance, we developed a poly(lactic-co-glycolic acid) (PLGA)-base... |
41977480 | Open-Source Molecular Docking and AI-Augmented Structure-Based Drug Design: Current Workflows, Challenges, and Opportunities. | Molecular docking is a foundational technique in computational drug discovery, widely used to generate binding hypotheses, prioritize compounds, and support target-selectivity studies. The continued growth of open-source docking resources, together with improvements in scoring functions, sampling strategies, and hardwa... |
41976747 | Effects of Crumb Rubber Content and Preparation Temperature on the Asphalt Performance and Fume Emissions of Deodorized Rubberized Asphalt. | While rubberized asphalt with a crumb rubber content of 20% to 40% can improve asphalt performance, it also faces prominent issues such as increased construction viscosity and intensified fume emissions. Currently, systematic studies on high-content deodorized rubberized asphalt across different preparation temperature... |
41976534 | Preparation and Characterization of Dual-Stabilized Vanillin Complexes Based on Soy Protein Isolate Through pH-Shifting Strategy. | Vanillin is widely used in foods, but its poor water dispersibility and limited stability reduce its flavor performance during processing and storage. In this study, soy protein isolate (SPI) was used as a food-grade carrier to prepare soy protein isolate-vanillin (SPIV) complexes via a pH-shifting strategy. SPI and va... |
41976245 | Recent Advances of Azobenzene-Based Photoresponsive Molecular Switches for Protein-Targeted Photopharmacology. | Azobenzene derivatives constitute a prototypical class of photoresponsive molecular switches with broad utility in synthetic chemistry and biomedical research, owing to their distinctive physicochemical properties. Recent molecular engineering has enabled red-shifted photoisomerization into the visible biological windo... |
41971165 | Preparing Adjuvanted Nanoliposomes for Applications Toward Recombinant Influenza Vaccine Development. | Nanoparticle vaccines can provide advantages over traditional vaccine methodologies, including adjuvant delivery to enhance the effectiveness of recombinant antigens. Many approaches exist to formulate different vaccine nanoparticles, which are designed for different biomolecular cargos, adjuvant compositions, and dise... |
41956054 | Drying-induced structural transitions in amyloid-like potato protein fibrils. | Amyloid-like fibrils derived from plant proteins are increasingly investigated as sustainable, label-friendly building blocks for food-grade functional materials. In this study, we clarified the structural transition of potato protein fibrils formed under combined acidic and thermal conditions and examined how dehydrat... |
41956053 | Evaluation of Zanthoxylum bungeanum sprouts amino acids profile by capillary electrophoresis and principal component analysis. | Zanthoxylum bungeanum sprouts (ZBS) rich nutritional component have long history of edible and favored by consumers. In this study, a facile, rapid method was proposed for assay the amino acids profile in ZBS based capillary electrophoresis. The effect of the concentration of borax, α-cyclodextrin (α-CD), and the pH of... |
41952811 | Normoxic stress enhance the secretion of adhesion-promoting membrane vesicles by <i>Streptococcus mutans</i>. | <h4>Background</h4><i>Streptococcus mutans</i> (<i>S. mutans</i>) is the primary pathogen of dental caries and one of the pioneer colonizers of dental plaque biofilms. The normoxic stress experienced by <i>S. mutans</i> during initial adhesion is detrimental to biofilm formation. Membrane vesicles (MVs) can modulate th... |
41950854 | Stereochemical profiling of essential oils from Cinnamomum Camphora using GC/MS: effects of sampling method and chiral separation. | A dual-mode headspace and liquid GC-MS approach was employed to analyse the essential oil extract of Cinnamomum camphora variant grown in Taiwan. Two β-cyclodextrin GC columns (Cydex-B and Rt-βDEXsm™) were compared for chiral separation. A note that Rt-βDEXsm™ column showed superior resolution for borneol and camphor i... |
41941926 | Susceptibility of naturally human papillomavirus type 16 major capsid protein L1 variants to vaccines and predictions of future evolutionary trends. | Human papillomavirus type 16 (HPV16) causes over 50% of HPV-related cervical cancers. With the widespread use of virus-like particle (VLP)-based HPV prophylactic vaccines, investigating the differences in viral assembly, infectivity and antigenic properties among different variants is highly important for further elimi... |
41937400 | Isoreticular Modulation of Electrical Conduction and Magnetic Properties in Semiconducting Lanthanide-based Based Metal-Organic Frameworks. | The integration of tunable magnetic properties and electrical conductivity within a single material presents significant opportunities for spintronic applications and quantum information processing. This paper describes the first systematic investigation of electrical conduction and magnetism in four novel isostructura... |
41937346 | Efficient Red Organic Room-Temperature Phosphorescence Enabled by Fused-Cyclization-Induced Planarization for Time-Resolved Luminescence Imaging. | Long-wavelength organic room-temperature phosphorescence (RTP) holds great promise for time-resolved luminescence imaging due to its long lifetime and minimized background interference. However, achieving efficient red RTP remains challenging, mainly because of rapid nonradiative decay and insufficient triplet-state po... |
41937209 | A dual-transformable MgGa-MOF nanoplatform for HCC therapy via lactate metabolism blockade and immune reactivation. | Microwave ablation (MWA) has emerged as one of the preferred modalities for treating hepatocellular carcinoma (HCC). However, its therapeutic efficiency is restricted by lactate accumulation after MWA. Lactate serves as a metabolic fuel for residual tumor cells, as well as acidifies the tumor microenvironment (TME) and... |
41937105 | Cyclobenzoin Macrocycles: Guest Capture and Applications in Energy Technologies. | Cyclobenzoins are organic macrocycles prepared by the benzoin condensation of aromatic dialdehydes. These compounds are easily derivatized into close to a dozen other macrocycle classes, which offer various supramolecular handles for the binding of environmentally and energy-relevant species in the solution and the sol... |
41937103 | Bipyrimidine-Boosted Preparation and Post-Functionalization of Vinylene-Linked Covalent Organic Frameworks for Sacrificial-Agent-Free Photocatalysis of CO<sub>2</sub> Reduction. | In nature, photocatalytic reduction of carbon dioxide is a critical process for maintaining the global carbon cycle, which is initiated by the enzymes consisting of chromophoric organic macrocycles in the presence of water. It is extremely desirable to develop an artificial organic photosynthetic system for the efficie... |
41935984 | A perspective on magnetic ionic liquids as multifunctional platforms for drug delivery and biomedical applications. | The demand for advanced field-responsive materials has positioned magnetic ionic liquids (MILs) as a transformative class of tunable fluids that bridge materials science and biomedicine. Initially valued for magnetically induced behaviors, MILs excel in surface activity, solubility enhancement (up to 39,000-fold for po... |
42004542 | A comprehensive review on structural, chemical, and functional perspectives of dietary polysaccharide-driven gut microbiota modulation: Mechanisms and challenges. | Polysaccharides in the diet have been increasingly recognized as major modulators of gut microbiota and multifunctional ingredients in food systems. Despite extensive research on various polysaccharides regarding their prebiotic activities, a comprehensive approach towards an integration of structural characteristics, ... |
42004297 | Functionalized carbon metal nanocomposites for efficient and sustainable removal of pharmaceutical contaminants from water - A comprehensive review. | Carbon-metal nanocomposites have emerged as promising materials for the sustainable remediation of pharmaceutical pollutants in aquatic environments by integrating the high surface area, chemical tunability, and structural stability of carbon nanomaterials with the catalytic and redox functionalities of metallic nanopa... |
41972656 | Lutetium-177 Radiolabeled Gold Nanoparticles for Prostate Cancer Theranostics. | Gold nanoparticles (AuNPs) have been extensively studied in cancer treatment research since they have special physicochemical characteristics such as facile surface functionalization with various chemical groups, low toxicity, favorable biocompatibility, and the ability to passively accumulate in tumors through the enh... |
41972582 | Unveiling Emergence and Holism in Biology: Essential Insights from Self-Organization. | This essay re-examines the enduring conceptual landscape of <i>self-organization</i> with the objective of clarifying the fundamental role of <i>emergence</i> and <i>holism</i> in contemporary biology. A deeper appreciation of these concepts can help biologists establish a solid theoretical foundation, avoiding biases ... |
41966593 | Interaction between amphiphilic drugs and biofilms revealed by surface-enhanced Raman spectroscopy. | This study adopted surface-enhanced Raman scattering (SERS) to assess membrane lipid order and to disclose structure-dependent differential interaction mechanisms between drug molecules and cell membranes by constructing lipid-coated metal nanoparticle conjugates. A dipalmitoyl phosphatidylcholine (DPPC)/cholesterol me... |
41950704 | Polyethyleneimine-based magnetic molecularly imprinted polymer for selective enrichment and highly sensitive determination of gallic acid in tea. | A polyethyleneimine-functionalized magnetic molecularly imprinted polymer (MHNT-PEI@MIP) was developed for selective enrichment and detection of gallic acid (GA) in complex tea matrices. Halloysite nanotubes provided a low-cost, high-surface-area substrate with abundant hydroxyl groups for polyethyleneimine (PEI) graft... |
41950683 | Defect engineering-mediated OER-enhanced ECL for ultrasensitive detection of E.coli. | The electrochemiluminescence (ECL) system of Luminol is frequently constrained by its sluggish reaction kinetics and strong dependence on dissolved oxygen in practical applications. Herein, we report an innovative strategy for enhanced oxygen evolution reaction (OER) catalysis mediated by defect engineering, which prov... |
41950648 | Structure-guided discovery of a potent 2-aryl-4-aminoquinazoline-based inhibitor overcoming osimertinib resistance driven by EGFR C797S mutation in NSCLC. | The C797S mutation in epidermal growth factor receptor (EGFR) is a major mechanism of resistance to third-generation tyrosine kinase inhibitors (TKIs), such as Osimertinib, in non-small cell lung cancer (NSCLC), creating an urgent need for effective therapeutic strategies. To address this challenge, we designed the str... |
41946286 | Unlocking the catalytic mechanism of ultrathin single-atom two-dimensional metal-organic framework nanozymes for dual-mode biosensing of hydrogen peroxide in tumor cells. | Metal-organic framework (MOF) nanozymes serve as promising biomimetic interfaces for biocatalysis, yet bulk three-dimensional (3D)-MOFs still suffer from insufficient active site accessibility and unclear catalytic mechanisms. Herein, this study reported the rational design of an ultrathin two-dimensional (2D) single-a... |
41942042 | Construction of a scaffold-mediated dual-enzyme display system in Komagataella phaffii with immobilized cells for continuous biocatalysis. | Scaffold-mediated yeast surface display enhances enzyme-enzyme proximity and substrate channel efficiency through the spatial self-assembly of enzyme molecules, overcoming limitations such as enzyme dispersion and mass transfer in traditional multi-enzyme systems. Despite its potential in biocatalysis, existing scaffol... |
41936139 | Advancements in Bimetallic Metal-Organic Frameworks for Oral Medicine. | The characteristic oral environment - with its dynamic clearance, moisture, microbial load, and inflammatory potential - makes oral diseases highly prevalent and therapeutically challenging. Metal-organic frameworks (MOFs), an emerging class of inorganic-organic hybrid porous coordination materials, have become pivotal... |
41935156 | Salt-saturated supramolecular solvent microextraction for spectrophotometric determination of curcumin in food samples. | A salt-saturated supramolecular solvent-based liquid-liquid microextraction method coupled with UV-Vis spectrophotometry was developed for the sensitive determination of trace levels of curcumin in food samples. Supramolecular solvents formed from decanol and tetrahydrofuran were employed as the extraction phase, while... |
41935056 | Therapeutic potential of BH3-mimetics and NK cell-mediated immunotherapy in T-ALL. | T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy of T-cell precursors. Although the survival rates have improved with the use of intensive chemotherapy, the emergence of relapse as well as treatment-related morbidity and mortality remain major challenges. Novel treatment approaches include the in... |
41935045 | A universal atomically dispersed cobalt catalyst for alkylation of ketones alcohols and lignin-derived compounds. | Catalytic carbon-carbon bond-forming reactions provide the basis for synthetic organic chemistry. To move towards a circular carbon economy, it is imperative to efficiently convert sustainable and inexpensive starting materials, e.g. broadly available renewable feedstocks, in an economically viable and practical manner... |
41934569 | An overview of the developments in 3D cancer cell models, assay techniques, and imaging modalities. | Cancer biology is a constantly evolving field of study due to the dynamic and complex nature of biological systems. The unique role of in vitro assays in cell biology has led to numerous transformations in our understanding of the functional and structural details of the cells and tissues that comprise these systems. H... |
41934405 | Failsafe Interstitial Design Enables Decoupled Control of Stiffness and Toughness. | Many structural materials suffer from a trade-off between stiffness and toughness because the same molecular interactions that form their rigid frameworks also restrict the plastic deformation needed to resist fracture. Here we demonstrate a failsafe design principle in which flexible polymers are embedded within the i... |
41934386 | Unraveling Green-Solvent-Driven Morphology Evolution in an Unconventional Small-Molecule Donor/Polymer Acceptor Solar Cell with over 13% Efficiency. | High-performance acceptor-donor-acceptor type photovoltaic materials, including small-molecule donors (SMDs) and polymer acceptors (PAs), have driven significant development in organic photovoltaics (OPVs). Nevertheless, the power-conversion efficiencies (PCEs) of SMD/PA systems still lag far behind those of mainstream... |
41934178 | Creating Anionic Microenvironment Around Single-Atom Fe Sites in Metal-Organic Frameworks for Enhanced Nitrate Electroreduction. | The electrocatalytic nitrate reduction reaction (eNO<sub>3</sub>RR) offers a sustainable strategy for both NO<sub>3</sub> <sup>-</sup> wastewater remediation and value-added NH<sub>3</sub> production. However, its application is hindered by sluggish reaction kinetics in neutral media due to the limited availability of ... |
41934181 | Versatile Synthesis of Mesoporous Nanomaterials via Monomicelle-Directed Assembly. | Mesoporous nanomaterials have attracted significant attention due to their diverse compositions and multileveled architectures. The soft-templating strategy serves as a foundational methodology for synthesizing mesoporous materials, achieving structural modulation via manipulation of thermodynamic and kinetic pathways ... |
41934180 | Click Capture SELEX for the Identification of Click-Modified Aptamers Targeting Small Molecules in Solution. | Capture SELEX is an in vitro selection method used to identify aptamers that bind small molecules in solution. The interaction of aptamers with their targets is primarily determined by supramolecular interactions, which are constrained by the chemical diversity of the canonical nucleobases. To overcome this limitation,... |
41934164 | Tunable and Low-Acidity PEDOT:SAM Supramolecular Complex Hole-Transport Materials for High-Performance All-Perovskite Tandem Solar Cells. | The development of advanced hole-transport materials (HTMs) is critical for next-generation optoelectronics. While poly(3,4-ethylenedioxythiophene): polystyrenesulfonate (PEDOT:PSS) is one of the most widely used HTMs, its inherent acidity and poor interfacial stability represent a universal challenge across diverse de... |
41931974 | A synergistic strategy via trace cobalt doping: Mesoporous engineering and electronic structure modulation of ZIF-8 derivatives for superior acetone sensing detection. | Accurate detection of exhaled acetone is of great significance for intelligent diabetes management; however, its low concentration (ppm level) and the high-humidity breath environment impose substantial challenges on the sensitivity and selectivity of sensing materials. In this work, a synergistic strategy integrating ... |
42011263 | Unlocking the acquired ultraviolet-resistance and enhanced antioxidant potential of pterostilbene-loaded pharmaceutical-dots. | Ultraviolet (UV) radiation, particularly UVA and UVB, induces skin damage through oxidative stress and inflammation. However, existing UV protection materials fail to simultaneously block UV rays and scavenge reactive oxygen species (ROS). To address this dual challenge, we developed pterostilbene (PTE)-loaded Tween 80... |
42009424 | Post-synthetic modification strategy for constructing dual-emission fluorescent sensor toward visual detection and quantification of 3-nitrotyrosine biomarker. | <h4>Background</h4>As the biomarker of oxidative stress (OS), 3-nitrotyrosine (3-NT) levels in serum is closely associated with disease progression, and the development of rapid and reliable fluorescent sensor is therefor urgent. Metal-organic frameworks (MOFs) are attractive for their diversified, easily designed and ... |
42009423 | Simultaneous colorimetric and homogeneous electrochemical detection of furfuryl alcohol based on peroxidase-like activity of MXene/Mn-MOF composite. | Accurate and rapid detection of furfuryl alcohol (FFA) in complex matrices is significant for environmental and food safety. Herein, a transition-metal carbides/manganese-based metal-organic framework (MXene/Mn-MOF, denoted MXM) composite has been rationally designed and synthesized, exhibiting excellent electrical con... |
42006730 | Redox-responsive peptide folding enables intracellular self-assembly and controlled nucleic acid release. | Intracellular peptide self-assembly provides a powerful strategy for spatiotemporal control of biomolecular interactions, yet most existing systems rely on irreversible triggers, limiting dynamic regulation. Herein, we report a redox-responsive amphiphilic peptide with a strategically positioned intramolecular disulfid... |
42006723 | Recent advances in immunoregulatory biomaterials for tendon healing: From immune remodeling to functional regeneration. | Tendon injury is a prevalent musculoskeletal disorder characterized by delayed healing, functional impairment, and diminished quality of life. Tendon repair is a dynamic process driven by immune regulation of tissue remodeling.This review summarizes the immunological mechanisms underlying tendon healing. In the early i... |
42006711 | High-performance hydrogels in orthopedics: Structural design, performance tuning, and clinical potential. | Orthopedic diseases (<i>e.g.</i>, bone defects, degenerative spinal conditions, fracture non-unions, and bone infections) pose significant challenges to traditional clinical treatment strategies. Since hydrogels are polymeric materials characterized by three-dimensional hydrophilic network structures, they have broad a... |
42006717 | Phase-separated hydrogels for advanced biomedical engineering: From material design to applications. | Hydrogels are extensively employed in wound healing, drug delivery, and the manufacturing of medical devices due to their distinctive physical and chemical properties and biocompatibility. The development of manufacturing platforms such as bioprinting and microfluidics has further advanced the clinical application of h... |
42004619 | Nanozymes for ferroptosis-based cancer theranostics. | Nanozymes, engineered nanomaterials with enzyme-mimetic activities, have emerged as versatile platforms for ferroptosis-based cancer theranostics. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has emerged as a promising strategy to overcome resistance to conventional cancer t... |
42000419 | A bistable catanionic system with reinforced thermal stability. | We investigate the structural and thermal behavior of "true" catanionic nanodiscs formed from cetyltrimethylammonium hydroxide and stearic acid in aqueous solution. In this pseudo-ternary system, the molar ratio between the cationic surfactant and the fatty acid governs both the effective surface charge and the interna... |
41976384 | Photodynamic Therapy-Based Strategies Targeted at Cancer Stem Cells: A Scoping Review. | A major challenge in cancer treatment is the presence of cancer stem cells (CSC), which play a significant role in therapeutic resistance, metastatic progression, and tumor relapse, highlighting their importance as therapeutic targets. Photodynamic therapy (PDT) can be a valuable strategy for targeting CSC by increasin... |
41976237 | Titanium Dioxide in Biomedical and Environmental Nanotechnology: From Photocatalytic Detoxification to Targeted Therapeutics. | Titanium dioxide (TiO<sub>2</sub>) has evolved from a conventional photocatalyst into a sophisticated nano-platform that bridges environmental sustainability and biomedicine. This paper proposes a unified interfacial redox design framework that links the electronic-structure engineering of the TiO<sub>2</sub> with the ... |
41976233 | Choline Chloride-Based Deep Eutectic Solvents for Efficient Polyphenol Extraction from White Mulberry (<i>Morus alba</i>). | The efficiency of six deep eutectic solvents (DESs) based on choline chloride (ChCl) and various hydrogen bond donors (HBDs) was evaluated against a traditional organic solvent for extracting polyphenolic bioactive compounds from three different white mulberry samples (<i>Morus alba</i>), including branches, leaves, an... |
41976235 | Molecularly Targeted Therapies in Oncology: Mechanisms, Resistance, and Combination Strategies. | Targeted therapies are reshaping oncology by enabling treatment selection based on actionable molecular alterations, improving precision, and reducing unnecessary toxicity. This review provides an up-to-date overview of current targeted treatment modalities and the medicinal chemistry principles that support their disc... |
41967451 | Integrative network pharmacology and molecular simulation analysis reveals the therapeutic potential of Coscinium fenestratum alkaloids against SARS-CoV-2. | SARS-CoV-2 variants resist all direct antivirals across clades, necessitating immediate therapeutic interventions that use conserved inflammatory mechanisms not utilized in existing pharmacotherapy. Even though Coscinium fenestratum is known to contain alkaloids like berberine, palmatine, and tembetarine, and tradition... |
41953858 | Micro/Nanoparticles in the Nose-Brain Axis: Implications for Pathogenesis and Therapeutic Interventions. | The nose-brain axis (NBA) is a crucial bidirectional deliverypathway between the nasal cavity and the central nervous system (CNS) that influences both neurophysiology and disease progression. In addition to serving as a route for drug delivery, the NBA plays an active role in neurological disorders by mediating inflam... |
41950652 | An artificial intelligence model for accurate drug-target affinity prediction in medicinal chemistry. | Predicting Drug-Target Affinity (DTA) with high fidelity is critical for accelerating hit-to-lead optimization and understanding mechanism of action. While deep learning has transformed this field, current approaches often struggle with the effective encoding of protein semantics and the modeling of complex, non-covale... |
41941862 | Regulation of long non-coding RNAs by essential oils: Therapeutic implications in human diseases. | Essential oils are natural substances with broad therapeutic potential due to their antioxidant, anti-inflammatory, and anticancer properties. Recent studies have demonstrated that these compounds can modulate the expression of non-coding RNAs, such as lncRNAs, miRNAs, and circRNAs, which play crucial roles in post-tra... |
41941844 | A graphene FET biosensing platform integrated with Fe₃O₄@SiO₂@Ce-Zr bimetallic MOFs for rapid SARS-CoV-2 detection. | A hybrid biosensing platform was developed for ultrasensitive detection of the SARS-CoV-2 nucleocapsid (N) protein by integrating an antibody-engineered magnetic bimetal-organic framework with a graphene field-effect transistor (GFET) readout. In this design, Fe₃O₄@SiO₂@Ce-Zr MOF particles were prepared and functionali... |
41939243 | Lactylation Modification: From Basic Biological Process to Clinical Cardiovascular Diseases. | Cardiovascular diseases (CVDs) remain the leading cause of death worldwide and are hallmarked by profound disturbances in energy metabolism and maladaptive tissue remodeling. Lactate, long dismissed as a metabolic waste product, is now recognized as a context-dependent central carbon source and signaling metabolite. A ... |
41936919 | Cholesterol, but not its oxidized derivatives, is essential for the transport activity of ASC1 (SLC7A10). | The neutral amino acid transporter ASC1 (SLC7A10) plays a key role in the regulation of amino acid homeostasis in neurons and adipose tissue, thereby contributing to neurotransmission, metabolic balance and redox homeostasis. Although the 3D structure of ASC1 has recently been solved, regulatory properties remain large... |
41936906 | Protein exosites as drug targets: from structural topology to therapeutic modality. | Bivalirudin's FDA approval (2000) validated bivalent thrombin inhibition via simultaneous engagement of the catalytic site and exosite I as a route to selective anticoagulants. Yet clinical translation of exosite targeting has largely remained confined to coagulation. ExositeDB, to our knowledge the first systematic ca... |
41936878 | Advanced nanotechnologies for protein modulation: From Nano-PROTAC to Nano-APROM. | Protein homeostasis plays a pivotal role in disease pathogenesis, making targeted protein modulation a transformative approach for therapeutic development. Current protein-targeting strategies primarily converge on two complementary approaches: selective degradation of pathogenic proteins and direct modulation of aberr... |
41936879 | Targeted microwave sensitizers reprogram cancer-associated fibroblasts via nitric oxide delivery to potentiate hepatocellular carcinoma therapy. | Microwave ablation (MWA) has emerged as a locoregional therapeutic modality for the management of various solid tumors. However, MWA often struggles to completely eliminate tumor cells without damaging surrounding healthy tissue. This triggers the persistence of an immunosuppressive microenvironment in the vicinity of ... |
41936875 | Treatment of skin cancer: From conventional to nanotechnological approaches. | Skin cancer represents a global health challenge with rising incidence rates, requiring the development of comprehensive therapeutic strategies. Although conventional therapies, both local (surgery, radiotherapy) and systemic (chemotherapy, immunotherapy, molecular therapy), remain the cornerstone of managing various t... |
41936053 | Exercise induces sex-specific assembly of mitochondrial supercomplexes. | The mitochondrial respiratory complexes of the electron transport chain (ETC) form supramolecular structures known as supercomplexes (SCs) whose functions remain partially understood. An increase in carbohydrate oxidation, such as that induced by high-intensity contractions within skeletal muscle (SKM), has been propos... |
41933921 | Multifunctional Eutectic Mixtures Enable Integrated Recovery of U, Pu, and Sr From Nuclear Waste. | Addressing the challenges of nuclear waste management and strategic resource recovery necessitates novel functional materials for the integrated and efficient capture of critical elements. This work reports a class of multifunctional eutectic mixtures (EMs) constructed from crown ether (hydrogen-bond acceptor, HBA) and... |
41933291 | The functional and catalytic landscape of urease reveals a conserved target against <i>Helicobacter pylori</i>. | Nearly half of the global population is infected with <i>Helicobacter pylori</i>. Antibiotic use has led to substantial antimicrobial resistance and unintended gut microbiota depletion, creating an urgent need for alternative therapeutic strategies. Here, we demonstrate that urease, a key enzyme that enables <i>H. pylo... |
41932873 | Advancing non-faradaic impedance biosensors: sensitivity enhancement strategies using microfluidics, multiscale labeling, and CMOS technology. | Impedance biosensors represent a critical technology for next-generation diagnostics, offering label-free detection with inherent compatibility for miniaturization. Among these, non-Faradaic impedance biosensors, which measure electrical property changes without electrochemical reactions, provide simplified operation b... |
41932811 | Targeting PAR-2 with a negative allosteric modulator increases tumor antigen presentation and potentiates anti-PD-1 immunotherapy. | <h4>Background</h4>Identifying the mechanisms underlying resistance to immune checkpoint inhibitors (ICIs) has become a major focus in cancer immunotherapy. Our previous work identified <i>F2RL1</i> expression, encoding the G protein-coupled receptor Protease-Activated Receptor-2 (PAR-2), as a negative biomarker of ICI... |
41931717 | Coassembled Prodrug Nanoparticles Mitigating the Acquired Resistance to Protein Degradation Therapy. | PROTACs (Proteolysis TArgeting Chimeras) represent an emerging class of anticancer therapeutics that induce the selective degradation of pathogenic proteins. However, the therapeutic efficacy of PROTACs is often compromised by their insufficient tumor distribution, poor bioavailability, and emergence of acquired resist... |
41931678 | Enhanced Mass Flow for the Improvement of Photocatalytic Hydrogen Peroxide Production Based on Multiple Junction Engineering and Local Bernoulli Effect. | Hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) is a promising environmentally benign oxidant and renewable energy carrier, and solar-driven photocatalytic H<sub>2</sub>O<sub>2</sub> synthesis represents a green alternative to the traditional anthraquinone process. However, the practical performance of photocatalysts is... |
41931621 | Biaxially ductile supramolecular polymer networks. | Supramolecular polymer networks are transiently cross-linked soft materials that have exceptional material properties such as high toughness, contractility, and recyclability. Previous studies have focused on optimizing their uniaxial mechanical features but did not manage to impart them with biaxial ductility. Here, w... |
41931620 | Phospholipid-driven conformational switching of HCV NS5A links protein folding to replication membrane remodeling. | Phospholipids are essential for RNA virus replication, yet their role in modulating conformational dynamics of membrane-associated viral proteins remains poorly understood. For NS5A, a key replication factor of hepatitis C virus, previous crystallographic models fail to capture the lipid-driven conformational mechanics... |
41931616 | Phosphorylation of PfiA modulates Pf4 phage production through PfiA/PfiT stoichiometric reconfiguration in <i>Pseudomonas aeruginosa</i>. | Filamentous Pf bacteriophages are widely distributed in <i>Pseudomonas aeruginosa</i> and profoundly influence biofilm formation and host virulence. The Pf4 prophage encodes a type II toxin-antitoxin (TA) system, PfiAT, modulating Pf4 propagation; however, its mechanistic role remains unclear. Here, through structural ... |
41931535 | Discovery of a potent anti-Zika virus benzamide series targeting the viral protein NS4B. | Zika virus (ZIKV), a member of the Flaviviridae family, causes significant public health concerns through congenital Zika syndrome and Guillain-Barré syndrome, yet no effective anti-ZIKV drugs or vaccines are available. To address this critical need, we conducted phenotypic, cytopathic effect-based high-throughput scre... |
41931517 | How do RNA molecules distinguish self from non-self? | RNA molecules form homotypic clusters in a variety of contexts. mRNAs enriched in germ granules in <i>Drosophila</i> embryos are a canonical example, with <i>polar granule component</i> (<i>pgc</i>) mRNAs colocalized with other <i>pgc</i> mRNAs, and <i>nanos</i> mRNAs with other <i>nanos</i> mRNAs. The observation of h... |
41931381 | Elucidating Odorant Masking Effects in Food Matrices through Olfactory Receptor-Based Profiling. | Dynamic interactions among aroma compounds, especially odorant masking, constitute key determinants of the intricate flavor profiles of thermally processed foods. However, the molecular- and receptor-level mechanisms governing mutual odor suppression remain largely unclear. This study investigated the reciprocal sensor... |
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