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42006716 | Carbohydrate polymer-based biomaterials for light-triggered Photo-Immunotherapy: Design strategies, immune mechanisms, and translational outlook. | Recent advances in biomaterials have highlighted the immense potential of carbohydrate polymers (CHPs) as biocompatible, multifunctional platforms for cancer therapy. Indeed, the structural diversity, tunable chemistry, and inherent biological affinity of these polymers enable the precise design of systems for immune m... |
42006668 | Physicochemical properties of amyloid-like fibrils from ultrasonication-induced plum seed protein-catechin conjugates. | Amyloid-like fibrils show promise as natural functional ingredients in the food industry owing to their distinctive structure and properties. However, the compact conformation of many plant proteins often limits the efficient production of functional amyloid-like fibrils. In this study, amyloid-like fibrils were fabric... |
42006471 | Activation volumes associated with excited-state electron transfer across amidinium-carboxylate bridge. | Pressure was used to modulate interactions in an electron donor-acceptor system, composed of a zinc porphyrin (ZnP) and a fullerene (C<sub>60</sub>), held together by an amidinium-carboxylate salt-bridge (ZnP-H⋯C<sub>60</sub>). Two different trends evolved in steady-state absorption assays. Volume compression causes an... |
42006464 | Organic supramolecular assemblage-confined photoluminescence. | Organic supramolecular hosts can selectively bond to small functional molecules with chromophores, inhibiting molecular motion and isolating quenching factors through spatial confinement, thereby enhancing fluorescence and phosphorescence emission and expanding their applications in chemistry, biology, and materials sc... |
42006250 | High Drug Encapsulation Capacity in Cyclodextrin-Based Nanoparticles: Characterization and <i>In Vivo</i> Antitumor Efficacy in Tumor-Bearing Mice. | Insufficient drug encapsulation, typically at about 10 wt %, remains a major challenge in the design of nanotechnology-based drug delivery systems. In this study, we created cyclodextrin-based nanoparticles (CDNP_PEGs), synthesized by the hyperbranched polymerization of cyclodextrins using a diepoxy poly-(ethylene glyc... |
42005349 | PLGA based formulations with poly(2-oxazoline)s for controlled dexamethasone release from thin extrudates. | PLGA is a landmark in polymer-based drug delivery, due to its biocompatibility, biodegradability and great mechanical strength. However, its high mechanical resistance tends to be unfavorable for implantation, as it creates sharp edges upon rupture, which can cause damage to the patient. Adding polyethylene glycol (PEG... |
42005347 | Cargo-driven extracellular vesicles as pharmaceutical nanocarriers: A pharmaceutics-oriented comparison of animal exosomes and plant-derived exosome-like nanoparticles. | Exosomes and plant-derived exosome-like nanoparticles (PELNs) are increasingly investigated as biologically derived nanocarriers that can couple cargo protection with biointerface-enabled transport. From a pharmaceutics standpoint, their therapeutic performance is often cargo-governed (e.g., microRNAs and proteins) and... |
42003556 | Cryo-EM structures of anti Z-DNA antibodies in complex with antigen reveal distinct recognition modes of a left-handed geometry. | Double-stranded nucleic acids can undergo transitions from canonical B/A-forms to alternate left-handed Z-DNA/Z-RNA (Z-NAs). Z-NAs are implicated in processes such as neuroinflammation in Alzheimer's disease, Lupus Erythematosus, microbial biofilms, and type I interferon-mediated human pathologies. Since endogenous Z-N... |
42003555 | Epididymal extracellular vesicles harbor and convey mRNA to sperm for transfer to zygotes. | The epididymis plays a critical role in promoting sperm maturation, including remodeling the sperm RNA payload. While small RNAs have been extensively studied in this context, the epididymal contribution to larger sperm RNAs, such as messenger RNAs (mRNAs), remains underexplored. This is largely due to the translationa... |
42003325 | Elucidation of TICT Behavior of Styryl Pyridinium Dyes via Supramolecular Confinement With Cucurbit[7]uril. | Styryl pyridinium derivatives have been extensively explored as chromophoric dyes in the areas of biomolecular imaging and nonlinear optics. However, these chromophores are weakly emissive in aqueous medium and is generally assumed that it is due to the involvement of nonemissive TICT state formed through the torsinal ... |
42003320 | Mandelic Acid-Mediated Enantiomeric Enrichment of a Resorcinarene-Based Dissymmetric Coordination Capsule. | Resorcinarene-based coordination capsules provide rigid, well-defined cavities that can exhibit helicity under chiral induction, a feature that has previously been exploited using axially chiral biphenyl compounds and tartaric acid derivatives. However, these approaches generally require well-designed templates tailore... |
42003307 | Ag<sub>2</sub>CO<sub>3</sub>-Mediated Oxidative Access to Calix[4]Diphenoquinones: Synthesis, Conformational Features, and Cavity Encapsulation. | Calix[4]diphenoquinones represent a promising class of redox-active macrocycles with potential applications in supramolecular chemistry and functional organic materials, yet their systematic synthesis and structural characterization have remained limited. Here, we report a mild and efficient Ag<sub>2</sub>CO<sub>3</sub... |
42003072 | Perovskite Quantum Dot-Based Luminescent Sensors for Cu<sup>2+</sup> Detection: Stability Engineering and Performance Across Aqueous, Organic, and Confined Media. | Perovskite quantum dots (PQDs) have emerged as highly promising luminescent materials for sensitive and selective detection of heavy metal ions, particularly Cu<sup>2+</sup>, owing to their exceptional photophysical properties, defect-tolerant structures, and tunable surface chemistry. However, their practical implemen... |
42002339 | Exploring molecular-level rolling friction based on cyclodextrins for lubrication. | The minimization of friction through the replacement of sliding with rolling friction is well-established in macroscopic applications, yet achieving this objective on the molecular scale has proven elusive. Herein, we report a novel strategy for molecular-level rolling friction that utilizes the molecular rolling effec... |
42001502 | Structure and Dynamics of Imidazolium in an Ionic Liquid-PEGDA Iongel via IR, 2D-IR, and NMR Spectroscopy. | Fourier transform infrared absorption spectroscopy, ultrafast two-dimensional infrared spectroscopy, nuclear magnetic resonance spectroscopy, and density functional theory calculations show that, in iongels composed of 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ( [C2C1Im][Tf2N]$\left[\right. C_{2} C_... |
42001497 | From Mechanisms to Materials: Oximate Reactivity and Emerging Strategies for Organophosphate Detoxification. | The development of effective strategies for the detoxification of organophosphorus (OP) nerve agents has evolved from the early mechanistic studies of François Terrier and collaborators, who first elucidated the exceptional nucleophilicity of α-effect species such as oximes and hydroxamates, to the modern design of sup... |
42001329 | Antioxidant and Antibacterial Activities of Secondary Metabolites Produced by Streptomyces Isolates Against Extended-Spectrum β-Lactamase-Producing Bacteria. | Extended-spectrum β-lactamase (ESBL)-producing Gram-negative bacteria pose a severe therapeutic challenge globally. Streptomyces remain one of the most prolific natural sources of antibacterial and antioxidant secondary metabolites, yet their activity against ESBL-producing pathogens remains under-explored. Soil-derive... |
41999224 | Comparative Evaluation of Additives in Softwood Fractionation: Impacts on Lignin Recovery and Pulp Quality. | Lignocellulosic biomass fractionation with concurrent lignin stabilization via chemical modification has been shown to enhance delignification efficiency and enable the recovery of lignin with a low degree of condensation, thereby increasing the application potential of both carbohydrate and lignin fractions. In this s... |
41999200 | Cryo-EM Structures of Alcohol Oxidase Isozymes Reveal Structural Determinants of Cofactor Variation and Enzymatic Activity in Ogataea methanolica. | Ogataea methanolica is a methylotrophic yeast that can produce diverse recombinant proteins using methanol as the sole carbon and energy source. Unlike most yeast species, which possess a single alcohol oxidase, O. methanolica encodes two isoenzymes, Mod1p and Mod2p. This study examines the structural and functional di... |
42001228 | Metalloids: Semi as Metals yet Full of Antimicrobial Potential. | In the periodic table, the metalloids boron (B), silicon (Si), germanium (Ge), arsenic (As), antimony (Sb), and tellurium (Te) demarcate a borderline between the metals and non-metals. Also referred to as semi-metals, their behaviour is indeed characterized by inorganic ions, organometallic complexes, and covalent comp... |
41999170 | Efficient Sulfonation of Syndiotactic Polystyrene Membranes Assessed by Small-Angle Neutron Scattering. | The selectivity of the δ-form of syndiotactic polystyrene (sPS) toward small organic molecules enables homogeneous functionalization by sulfonation of sPS membranes via soaking in a chloroform solution of a bulky sulfonating agent such as lauroyl sulfate. Sulfonated syndiotactic polystyrene (s-sPS) is hydrophilic and s... |
41999168 | Cell-in-Shell Metacells in Single-Cell Nanoencapsulation. | Single-cell nanoencapsulation (SCNE) enables the direct integration of synthetic materials with living cells, forming cell-in-shell structures that augment native cellular functions without genetic modification. While SCNE has advanced applications in cytoprotection and cell-surface engineering, its full potential rema... |
41999158 | Eco-Friendly Mof-199/Phytagel Composite Solid Polymer Electrolytes for Supercapacitors. | Conventional liquid electrolytes in energy storage devices pose leakage and safety risks, driving interest in solid polymer electrolytes as safer alternatives. In this work, a flexible composite solid polymer electrolyte (CSPE) was developed using MOF-199 and the natural biopolymer phytagel, with NaCl as the Na<sup>+</... |
41999157 | Metal Nanoparticle-MOF Hybrid Biosensors for Early Detection of Infectious Diseases and Antimicrobial Resistance Markers. | The escalating threat of antimicrobial resistance (AMR) and the inadequacy of conventional diagnostics in early infection detection demand advanced biosensing strategies. This review highlights recent progress in biosensors based on metal nanoparticles (MNPs) and metal-organic frameworks (MOFs), focusing on their roles... |
41998822 | Identification of Key Genes Involved in Lactic Acid Metabolism in Periodontitis Based on Bioinformatics Analysis. | Lactic acid metabolism correlates with periodontitis progression. Using machine learning (LASSO and SVM-RFE) on GSE16134 and GSE173078 datasets, CFI and COQ2 were identified as key genes, with good diagnostic performance (AUC > 0.75). GSEA linked these genes to MAPK signalling, endocytosis, and ubiquitin-mediated prote... |
41996585 | Uracil-Peptide-Pyrene Conjugates as Cu<sup>2+</sup>-Sensitive Probes Targeting DNA, RNA, and Biorelevant Model Membranes. | We report a series of uracil-triazole-pyrene peptidomimetics (2-4) designed to achieve modular geometric control through peptide linkers of varying length and flexibility. All three compounds exhibited submicromolar affinity for ds-DNA, while compound 4 also showed strong binding to ds-RNA, demonstrating the advantage ... |
41996545 | Zinc-Porphyrin Terephthalate-Based Metal-Organic Framework: Structural Insights and Functional Antibacterial Properties. | Herein, we have synthesized the commonly known protonated 5,10,15,20-tetrakis(4-pyridyl)porphyrin (compound 1) and a mixed-linker zinc-based metal-organic framework (compound 2) and evaluated their antibacterial photodynamic therapy. The crystal structure of 1 exhibits hydrogen-bonded scaffolds and engages in π-stackin... |
41995450 | Structural insights into the nuclear import of ovine gammaherpesvirus 2 ORF73 LANA homologue. | Ovine gammaherpesviruses 2 (OvGHV2), a member of the <i>Macavirus</i> genus within the <i>Orthoherpesviridae</i> family, causes lymphoproliferative diseases in susceptible species, most notably sheep-associated malignant catarrhal fever. Research on OvGHV2 has been hindered by the absence of a permissive cell culture s... |
41995347 | Magnetic-Assisted Aptamer Selection and Isolation of Migrasomes for Application in Lung Adenocarcinoma Proteomic Analysis. | Migrasomes, newly discovered vesicular organelles, hold promise as diagnostic biomarkers and therapeutic targets in various diseases. However, the exploration of their clinical value remains hindered by the complexity of enriching and analyzing low concentrations of migrasomes in body fluids. To address this issue, a m... |
41995136 | Biochemical Upcycling of PET via Glycolysis and Engineered Microbial Consortia. | Polyethylene terephthalate (PET) waste remains a major environmental challenge due to its recalcitrance and low economic value. Here, we present an integrated biochemical approach that couples glycolysis with a synthetic microbial consortium to upcycle PET into polyhydroxyalkanoates (PHAs). Glycolysis efficiently depol... |
41994945 | Design, Synthesis and Evaluation of Anticancer Potential of Novel Pyrrolopyrazines Against Glioblastoma: Mechanistic Details and In Vivo Safety Analysis. | A protocol through propargyl moiety on pyrrole ring cyclization with ammonium acetate was demonstrated. With this protocol, 11 pyrrolo[1,2-a]pyrazine derivatives were synthesized, and their antiproliferative activity against the U87MG glioblastoma cell line was evaluated. Among the synthesized compounds, a naphthyl-sub... |
41994936 | Fully Synthetic Non-Carbohydrate Heparin Mimetics-Perspectives for Therapeutic Anticoagulation and Beyond? | Heparin is one of the oldest drugs on the market. Although clinically well established as an anticoagulant for decades, owing to its natural origin and heterogeneous glycosaminoglycan polysaccharide structure, ensuring consistent quality and reproducible biological activity remains challenging. While these facts argue ... |
41994657 | EMILIN-1 in the tumor microenvironment: insights from CNS tumors and beyond. | Elastin Microfibril Interface Located Protein 1 (EMILIN-1) is a multifunctional extracellular glycoprotein, primarily involved in maintaining tissue homeostasis. Known for regulation of elastogenesis and vascular stability, EMILIN-1 has emerged as a key modulator of multiple biological processes, including cell adhesio... |
41994645 | Plasminogen activator inhibitor-1 as an oncologic target: biology, therapeutic inhibitors, and clinical translation. | Plasminogen activator inhibitor-1 (PAI-1) is a key regulator of cancer biology, influencing tumor progression, metastasis, and therapeutic resistance. Elevated levels of PAI-1 are consistently associated with poor prognosis across several malignancies, including breast, ovarian, lung, hepatobiliary, colorectal, and gli... |
41994434 | Metamizole-induced agranulocytosis from a German intensive care perspective. | <h4>Background/objectives</h4>Metamizole (dipyrone) is a non-opioid analgesic and antipyretic widely used in Germany, with prescriptions having increased more than tenfold since 1997. Despite its popularity, metamizole remains controversial due to the risk of agranulocytosis-a potentially life-threatening adverse react... |
41994415 | Platelet-related hematologic markers and genetic associations of aspirin resistance in kawasaki disease. | Kawasaki disease (KD) is the leading cause of acquired cardiovascular disease in children and is characterized by intense immune activation and platelet dysfunction. High platelet reactivity (HPR) is increasingly recognized as a biological basis of aspirin resistance (AR), which may increase the risk of adverse coronar... |
41994275 | Qifuyin improves physiological frailty by regulating the intestinal flora in 3xTg-AD mice. | <h4>Objective</h4>Alzheimer's disease (AD) is often accompanied by motor dysfunction, impaired limb strength, and gut microbiota disturbances. This study aimed to evaluate the effects of Qifuyin (QFY), a traditional Chinese medicine formula, on motor deficits, limb strength, aging, and gut microbiota composition in 3xT... |
41994264 | The first report of porcine parvovirus 8 detection and genetic analysis in South Korea. | Porcine parvoviruses (PPVs) are small, non-enveloped, single-stranded DNA viruses that infect pigs. Recently, a novel porcine parvovirus 8 (PPV8) was identified in China and subsequently detected in several countries, suggesting its global distribution. This study aimed to investigate the presence and molecular charact... |
41994201 | <i>P. falciparum</i> PEBP protein is dispensable during asexual and sexual stages of development. | Malaria, a life-threatening disease caused by protozoan parasite <i>Plasmodium</i> and transmitted by mosquitoes, remains a significant threat to health worldwide, especially in the face of emerging drug resistance. Despite extensive effort having been devoted to examining the asexual phase of the parasite, the sexual ... |
41994203 | Technological innovations and breakthrough pathways in syphilis diagnosis: addressing global resurgence and the journey toward elimination. | The global resurgence of syphilis, characterized by a precipitous rise in incidence and the persistence of congenital transmission, has necessitated a critical re-evaluation of traditional diagnostic paradigms. This review synthesizes recent technological innovations in the detection of <i>Treponema pallidum</i>, spann... |
41993714 | Reactive oxygen species in skin diseases: pathogenic mechanisms and nanomaterial-based therapeutic strategies. | Reactive oxygen species (ROS) are inevitable by-products of aerobic metabolism and play a dual role in skin physiology and pathology. At physiological levels, ROS act as essential second messengers regulating cellular signaling and maintaining skin homeostasis. However, excessive ROS accumulation disrupts redox balance... |
41993585 | The physiochemical characteristics of Phragmites communis trin polysaccharides and <i>in vitro</i> anti-diabetic effects of their different fractions. | This study isolated and purified two polysaccharide fractions, PTP-1 and PTP-2, from <i>Phragmites communis</i> Trin root via cellulase-assisted ultrasonication and DEAE chromatography, with purities of 90.56% and 91.35%, respectively. Structural characterization revealed that PTP-2 possessed a higher uronic acid conte... |
41993212 | Robust CD8<sup>+</sup> T cell responses induced by an mRNA-LNP vaccine encoding rat HER2 extracellular domain confer prophylactic tumor protection. | <h4>Background</h4>HER2-positive cancers present challenges of drug resistance, toxicity, and immune tolerance. HER2-targeted peptide vaccines have failed clinically, while nucleoside-modified mRNA-lipid nanoparticle (mRNA-LNP) vaccines show promise for robust antitumor immunity. This study utilized heterologous immuni... |
41993206 | Reduced COVID-19 severity in Africa: a systematic review of host genetic and immunological responses to SARS-CoV-2 infection. | <h4>Background</h4>The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had immense global consequences, leading to widespread illness, deaths, and devastated economies. Despite this, Africa has experienced a high prevalence of asymptomatic coronavirus disease 2019 (COVID-19) and mild cases... |
41993062 | Fractionated ethanolic red ginger extract as antibacterial agent against <i>Aggregatibacter actinomycetemcommitans</i> and <i>Porphyromonas gingivalis</i>: In silico and in vitro studies. | <h4>Background</h4>Periodontitis is a chronic inflammatory disease associated with oral microbiome dysbiosis, where <i>Aggregatibacter actinomycetemcomitans</i> and <i>Porphyromonas gingivalis</i> contribute through adhesion, biofilm formation, and tissue-destructive virulence factors. Although chlorhexidine is widely ... |
41992883 | Advances in high-throughput screening of cyclic peptide drugs using mRNA display technology. | Cyclic peptides have emerged as a promising therapeutic modality for targeting classically deemed "undruggable" protein that defy conventional small-molecule intervention. Their rigid conformations improve binding affinity, selectivity and proteolytic stability, bridging the gap between low-molecular-weight drugs and l... |
41992795 | Anticonvulsant Effects of Citronellal, Daidzin, and Phytol, Possibly Through GABA<sub>A</sub> Receptor and Voltage-Gated Sodium Channel Interaction Pathways: In Vivo and In Silico Studies. | <h4>Background</h4>Natural compounds, such as citronellal (CTL), daidzin (DZN), and phytol (PHY), have demonstrated potential anticonvulsant properties, but their combined effects remain unexplored. This study aimed to evaluate the anticonvulsant efficacy of CTL, DZN, and PHY, individually and in combination, using in ... |
41992699 | Recent Developments in Sustainable Solubilization. | The large-scale use of toxic and environmentally hazardous solvents remains a major challenge in industrial manufacturing and consumer-goods production. Conventional solubilization processes often depend on harsh conditions, including elevated temperatures and pressures, resulting in high energy consumption, health ris... |
41992278 | Integrative bioinformatic analysis identifies an extracellular matrix gene signature linked to muscle adaptation to endurance and resistance training. | Skeletal muscle exhibits a remarkable adaptive capacity; endurance training enhances mitochondrial capacity, whereas resistance training improves mechanical strength. Despite these differences, both training impose repeated contractile and remodeling demands on skeletal muscle, suggesting a conserved transcriptional re... |
41989932 | Exploring the Diversity and Function of the SPFH-Domain Containing Proteins in Pseudomonas aeruginosa. | The SPFH-domain containing proteins are widely conserved membrane-associated factors proposed to organise membrane microdomains and thereby regulate key cellular processes. In Pseudomonas aeruginosa PA14, we identified nine such proteins (HflK, HflC and PaFlo3-PaFlo9) that display remarkable sequence divergence, genomi... |
41988976 | Synthesis of Pharmacologically Important Perimidines using Eco-Friendly Deep Eutectic Solvents. | In this study, we have presented a green and efficient protocol for the synthesis of diverse perimidine derivatives by employing deep eutectic solvents (DESs)-acting as reaction media and catalyst. Markedly, this method not only eliminates the need for hazardous solvents and expensive catalysts but also works under ope... |
41988954 | Chemoselective Alkylating Esterification of Thiophosphinic Acids: An Experimental and Theoretical Study. | Preparative experiments including the alkylation of diphenylthiophosphinic acid with a series of C<sub>1</sub>-C<sub>4</sub> haloalkenes at 75/115°C in the presence of triethylamine in toluene suggested chemoselective formation of the corresponding S- (thiolic) ester. No O-(thionic) ester was formed. For this, we wishe... |
41988887 | Heterojunction engineering in metal-organic frameworks for electrolytic water splitting: advances and perspectives. | The electrocatalysis of water is a promising means of producing hydrogen energy currently and has a profoundly important impact on energy storage and regeneration. In recent years, metal-organic frameworks (MOFs) have been widely studied and used in the field of electrolysed water. Due to their large specific surface a... |
41987759 | Buckybowls at the Biointerface: Sumanene and Corannulene as Emerging Platforms for Medicinal Chemistry. | Considering the widespread research on medicinal chemistry applications of fullerenes and other carbon nanomaterials, the biological features of sumanene and corannulene buckybowls have been widely discussed and anticipated over the years. Over the last fifteen years, progress has been made in designing sumanene and co... |
41987705 | Population Pharmacokinetic Modeling of Intravenous Topiramate in Patients with Epilepsy or Migraine. | Topiramate (TPM) is approved for seizures and migraine prophylaxis and is used off-label for several neuropsychiatric conditions. The available dosage forms, including tablets and sprinkle capsules, are unsuitable for patients who may be unable to take medicine orally. The resulting potential treatment interruption cou... |
41985250 | Haplotype-phased 'Ottawa 3' genome unravels differential reaction of apple rootstock roots to mixed viral infection. | Viral diseases pose a significant threat to global apple (Malus spp.) production. While selecting appropriate rootstocks is a crucial strategy to mitigate their effects, the underlying mechanisms governing rootstock tolerance or sensitivity to viral infection at the root level remain underexplored. We conducted an aero... |
41985189 | Back to the Electrofuture: Named Reactions Powered by Electroorganic Syntheses. | The practice of assigning names to chemical reactions in organic synthesis serves not only as a systematic communication tool but also as homage to distinguished scientists. These named reactions have been pivotal in facilitating effective knowledge exchange among chemists and fostering advancements in education as wel... |
41985182 | Advanced Nanomembranes for Membrane Distillation Desalination: Research Status, Challenges, and Prospects. | The increasingly severe global shortage of freshwater resources underscores the critical importance of seawater desalination. Membrane distillation (MD), as an emerging thermally driven desalination technology, offers several advantages-including mild operating conditions, high salt rejection, and the ability to utiliz... |
41985177 | Synthesis of Biomass-Based MIL-101(Cr)@hydrochar for Efficient Conversion of Xylose to Furfural: Effects of Physicochemical Properties and Biomass Types. | Developing biomass-based solid acid catalysts and converting biomass-derived molecules into high-value chemicals has a dual promoting effect on the high-value utilization of waste biomass. This study introduces a groundbreaking one-pot hydrothermal strategy integrating biomass with MIL-101(Cr) precursor to fabricate hi... |
41983370 | Modifying Effect of the Antibiotic Action, Membrane Permeability, and ADMET/Toxicity Profile of the Fixed Oil From the Pulp of Mauritia Flexuosa F.L. (Arecaceae). | The increasing bacterial resistance to antibiotics has stimulated the search for natural products capable of modulating antimicrobial activity. In this study, the fixed oil from Mauritia flexuosa pulp was evaluated for its antibacterial activity, modulatory effect on antibiotics, membrane permeability, and ADMET/toxici... |
41983312 | Structural and Binding Insights Into Carvacrol-Lawsone Combination as an AKT1-Targeted Strategy for Breast Cancer Therapy. | This study explores the combinatorial potential of carvacrol-lawsone adduct (CALA) by analyzing its structural, electronic, and binding features against breast cancer-associated targets. Density functional theory (DFT) calculations optimized the CALA structure, revealing band gap energies of 2.036 eV (without GD3) and ... |
41982126 | Base Editing of TIGIT Reprograms CD155 Signaling in Natural Killer Cells to Enhance Cancer Immunotherapy Efficacy. | NK cells hold great promise for cancer immunotherapy owing to their intrinsic capacity to recognize and eliminate malignant cells. Nevertheless, broad clinical deployment is hindered by NK-cell properties like poor expansion and refractoriness to genetic modification, as well as by tumor immune-evasion mechanisms. In t... |
41981885 | Electromembrane Extraction Assisted by a Metal-Organic Framework and Covalent Organic Framework Composite Incorporated Into Hollow Fiber Membranes for Drug Analysis in Biological Samples. | An assisted electromembrane extraction method using a novel composite of metal-organic framework and covalent organic framework incorporated into the wall pores of a hollow fiber membrane is presented. The metal-organic framework and covalent organic framework composite combines the high surface area, tunable porosity,... |
41981444 | [Bifunctional biomaterials: An innovative strategy for synergistic bone tumor therapy and bone regeneration]. | <h4>Objective</h4>To review research progress of bifunctional biomaterials in the treatment of bone tumors and bone defects in recent years, aiming to provide assistance for the further research of bifunctional biomaterials.<h4>Methods</h4>A wide range of domestic and international literature on the preparation and pro... |
41980197 | Structural insights into glycan recognition by plant immune receptors: a comparative perspective with animal innate immune systems. | Pattern recognition receptors (PRRs) function across diverse eukaryotic organisms as a powerful surveillance system to perceive danger signals and to trigger specific adaptive responses. This complex receptor network constitutes the first layer of perception of the innate immune system of plants and mammals. PRRs speci... |
41979055 | PREDICTOR: A Non-Enzymatic Catalytic Cascade Tool for in Situ Visualization of Small Extracellular Vesicle Surface glycoRNAs. | Glycosylated RNAs (glycoRNAs) are membrane-displayed RNA-glycan conjugates, but quantitative in situ analysis of low-abundance glycoRNAs on small extracellular vesicles (sEVs) remains challenging. Here, we develop PREDICTOR (proximity-encoded non-linear hybridization chain reaction circuit), an enzyme-free catalytic DN... |
41978952 | ESIPT-Active Naphthalene-Based Hydroxyoxime Fluorescent Chemodosimeters for Rapid and Sensitive Phosgene Sensing in Solution and Polymer Films. | Choking agents such as phosgene, diphosgene, and chlorine pose serious threats to public health due to their extreme inhalation toxicity. Exposure to these gases can cause severe damage to the respiratory system, leading to acute oxygen deprivation, respiratory failure, and potentially fatal outcomes. In this regard, t... |
41977618 | Lipid-Enriched Biopolymer Films for Active Packaging: A Review of Structure, Properties, and Preservation Performance. | Amid growing environmental concerns regarding the use of non-biodegradable plastic packaging and its potential emerging contaminants, such as microplastics, currently among the most pressing global challenges, researchers in the food sector are increasingly pursuing sustainable alternatives. In this context, various or... |
41977617 | Topology-Induced Reduction in the Order-Disorder Transition in AB Block Copolymer: A Unit-Matched Comparison of Diblock, Multiblock, Comb, and Star Architectures. | Chain topology offers a chemistry-preserving route to tune block copolymer (BCP) self-assembly by modifying intrachain correlations and relaxation pathways without changing monomer interactions. Here, we perform a unit-matched comparison of four lamella-forming AB architectures reconstructed from an identical constitut... |
41977616 | Are Polymeric Membranes Truly Sustainable? Life Cycle Assessment Studies of Polymeric Membranes in Post-Combustion CO<sub>2</sub> Capture: A Systematic Review. | Polymeric membranes are promising materials for post-combustion CO<sub>2</sub> capture (PCC), yet their life cycle environmental performance remains uncertain. This review synthesizes 21 life cycle assessment (LCA) studies of polymeric membrane-based PCC systems to examine methodological choices, quantify environmental... |
41976481 | Effects of Ammonia-Nitrogen-Reducing Biofilm on Stress Responses and Muscle Quality in Crucian Carp During Transportation. | This study evaluated the efficacy of ammonia-nitrogen-reducing biofilms (aquatic nitrifying bacteria biofilm media, a fixed-bed biofilm capable of simultaneous nitrification and denitrification) in mitigating water quality deterioration and transport-induced physiological stress in live-transported Crucian carp (<i>Car... |
41976473 | Upcycling Pomegranate Peel into Bioactive Microparticles to Improve Antimicrobial Potential in Apple Juice During Refrigerated Storage. | Unpasteurized fruit juices are prone to microbiological spoilage by bacteria, yeasts, and molds, creating a need for natural preservatives to extend shelf life without compromising quality. Pomegranate peel extract (PPE) exhibits antimicrobial activity primarily against pathogenic microorganisms; however, its effect on... |
41976474 | Remote-Controlled Microfluidic Platform for Real-Time Detection of Multiple Mycotoxins on Chip. | Food safety requires real-time monitoring of mycotoxins in food, as food products contaminated with these toxins poses major threat to human health. In this study, we proposed a remote-controlled microfluidic platform (RCMP) integrated with chemiluminescent/colorimetric detection system for rapid, cost-effective and re... |
41976211 | Engineering Strategies of Colloidal Drug Delivery Systems, a Rising Star in Ocular Neovascular Diseases. | Ocular neovascular diseases represent a major cause of irreversible vision loss worldwide, while the complex ocular barrier system significantly limits the efficacy of conventional treatment approaches. In this context, colloidal drug delivery systems (CDDSs) have emerged as an innovative nanomedicine strategy that dem... |
41976052 | Integrative Single- and Multi-Trait GWASs Identify Pleiotropic Loci Affecting Growth and Egg Production in Zhedong Geese. | Growth and egg production are the two most economically important traits in goose production systems. However, negative genetic correlations between these traits make it difficult to achieve balanced genetic improvement through selection. In this study, we analyzed whole-genome resequencing data from 1033 Zhedong White... |
41974048 | Selection of GhTT2-A07 promoter enhances fiber quality in improved cotton varieties. | Modern cultivated cotton fibers are predominantly white with enhanced quality compared to their wild ancestors. However, the molecular mechanisms and evolutionary drivers linking fiber color to quality remain least focused. In this study, we identified FQC1 (Fiber Quality and Color 1), a major quantitative trait locus ... |
41973068 | Hydrogen-Bond-Driven Molecular Recognition: A UV-Spectroscopic Strategy for Positional Isomer Discrimination Using (4,5-Diphenyl-1H-Imidazol-2-Yl) Aniline and Picric Acid. | A simple method, UV-Visible spectroscopy, was used to detect the positional isomers of imidazole derivatives. We synthesized 4,5-diphenyl-1H-imidazol-2-yl-aniline molecules, where -NH2 is present at different positions (ortho, meta, and para) and detected the para isomer using picric acid (PA). PA forms a binary self-a... |
41972858 | Overexpression or Activation of Potassium Channel TASK-3 Protects Retinal Ganglion Cells and Restores Visual Function in Optic Nerve Crush. | <h4>Purpose</h4>This study explored in a mouse model whether activation or upregulation of the two-pore domain potassium channel tandem pore domain acid-sensitive potassium channel 3 (TASK-3) in retinal ganglion cells (RGCs) could protect RGCs and reverse the vision loss arising through optic nerve injury.<h4>Methods</... |
41972830 | What If Trojan Horse Nanoparticles Could Change the Game for HPV Gene-Targeted Therapies? | Human papillomavirus (HPV) is a common sexually transmitted infection linked to various cancers, particularly cervical cancer, primarily driven by high-risk strains like HPV16 and HPV18. While vaccines are effective in preventing new infections, they do not address existing cases, highlighting the need for innovative t... |
41972649 | Nanocellulose Materials: Processing, Properties, and Application. | Nanocellulose materials (CNMs), encompassing cellulose nanocrystals (CNCs), cellulose nanofibrils (CNFs), and bacterial nanocellulose (BNC), have emerged as a versatile and sustainable class of bio-based nanomaterials with significant promise for applications in mechanical engineering. This review systematically examin... |
41970321 | Reconstituted phospholipid membrane-coated Fe<sup>2+</sup>-Mg<sup>2+</sup> displacement nanoparticles block ferroptotic trigger waves. | Ferroptotic trigger waves (FTWs) mediate the long-distance propagation of transient cell-death signals across tissues, resulting in spatially correlated, large-scale cellular dysfunction and programmed demise. Blocking of FTWs represents a promising therapeutic strategy for iron accumulation-related pathologies. Based ... |
41969646 | Inhaled formulations for bacterial pneumonia: Strategies and advances in drug delivery. | Inhaled formulations have garnered significant interest in the treatment of bacterial pneumonia, as they deliver the drug directly to the site of infection in the lungs, providing high local drug concentrations that are typically unattainable with oral or intravenous therapies. Technologies for inhalation formulations ... |
41969260 | [Deep eutectic solvent and improved needle filter-based liquid-membrane microextraction combined with high performance liquid chromatography for the determination of sulfonamide and fluoroquinolone residues in milk]. | Antibiotic residues in dairy products pose serious threats to food safety and affect human health. To accurately determine the level of sulfonamide and fluoroquinolone residues in milk， a deep eutectic solvent and improved needle filter-based liquid membrane microextraction （DES&INF-LMME） method combined with high perf... |
41969236 | Controlled Modification of Axial Coordination of Single-Atom Nanozymes for Biomedical Applications. | Natural enzymes and traditional artificial enzyme mimics are limited in biomedical applications by high costs, instability, or insufficient structural complexity. Nanozymes address some issues but lack sophistication and clear structure-activity relationships. Single-atom catalysts (SACs) bridge natural enzymes and nan... |
41969166 | Synthesis of Polyhydroxylated Pyrrolidinyl Analogs of Sugar Nucleotides. Experimental and Computational Studies on Their Interactions With GalNAC-T's. | Direct coupling between polyhydroxylated pyrrolidinyl β-amino phosphonates and uridine monophosphate (UMP) yields polyhydroxylated pyrrolidinyl analogs of sugar nucleotides suitable inhibitors of N-acetyl-galactosyltransferases. β-Amino phosphonates have been synthesized in an enantiomerically pure form through the nuc... |
41968635 | The Thoracic Lymphatic Vasculature: Interorgan Strategies to Achieve an Optimal Tissue Function. | In thoracic tissues, the lymphatic vasculature not only contributes to fluid and solute homeostasis but also plays a critical role in shaping overall tissue physiology. Although the general morphology of lymphatic vessels and their organization within the vascular circuit are largely conserved inter-organs, thoracic ly... |
41968591 | Efficient Machine Learning Prediction of Solvent-Dependent $$ {}^1\mathrm{H} $$ NMR Chemical Shifts in Zinc Complexes. | Accurate prediction of NMR chemical shifts in transition metal complexes remains challenging due to the wide range of coordination environments and complex electronic structures of these systems. In this work, we present a machine learning approach (ML) for rapid and accurate prediction of 1H$$ {}^1\mathrm{H} $$ NMR sh... |
41968525 | Plant NLRs are getting into higher-order architectures. | Nucleotide-binding leucine-rich repeat (NLR) proteins are central components of the plant immune system that detect pathogen-derived effectors or modifications of host proteins within the cell to activate immune responses. NLRs have co-evolved with pathogens in an ongoing evolutionary arms race, leading to diversificat... |
41968519 | Inconsistencies of Gaussian's "NBO 3.1" Module With Authentic Natural Population Analysis. | We provide illustrative examples of the discrepancies between "NBO analysis results" as obtained from Gaussian-16's proprietary NBO 3.1 module versus the authentic Natural Bond Orbital program as first developed in the 1980s and maintained in the current NBO7 program version. |
41967506 | Quantitative analysis of characteristic aroma components in rose hydrosol by reversed-phase liquid chromatography using hydroxypropyl-β-cyclodextrin as mobile-phase additive. | Quantitative determination of eight characteristic aroma components, namely, benzyl alcohol, phenylethyl alcohol, eugenol, geraniol, nerol, linalool, citronellol, and methyl eugenol, by reversed-phase high-performance liquid chromatography with hydroxypropyl-β-cyclodextrin as mobile-phase additive was investigated. The... |
41967141 | GC-MS method development and validation for the determination of Short Chain Fatty Acids in human feces. | Short Chain Fatty Acids (SCFAs), the end products of microbial fermentation of dietary fibers, appear to be key mediators of the beneficial effects elicited by the gut microbiome and have been shown to exert multiple effects on metabolism. In this study, we developed and validated a sensitive, accurate, and reproducibl... |
41965089 | High-Performance Aza-Coronene-Based Organic Semiconductors for Thin-Film Transistors and Ultrasensitive Herbicide Detection. | The rapid intensification of agricultural activities has necessitated the development of ultrasensitive platforms for monitoring herbicide runoff in food and water systems. This study reports the rational design, synthesis, and characterization of a novel series of hexabenzo-aza-coronene (HBAC) derivatives (5a-f) featu... |
41964382 | Human α2-Macroglobulin: Architecture, Mechanisms, and Functional Implications. | α2-Macroglobulin (α2M) is a large glycoprotein and one of the most abundant proteins found in the plasma of vertebrates and in the hemolymph of invertebrates. It performs several important functions in the innate immune system, serving as a pan-protease inhibitor and contributing to essential processes, such as cytokin... |
41961901 | A Review on Medicinal Chemistry and Biological Activity of Dihydropyrimidinones Against HIV. | Dihydropyrimidinones (DHPMs), also referred to as pyrimidinones, are privileged structures widely employed in the search for new compounds capable of inhibiting HIV replication. This core is found in natural alkaloids isolated from marine sponge species, which are known to inhibit the binding of the viral surface prote... |
41960724 | Targeted Photodynamic Activity of a Hyaluronic Acid-Protoporphyrin IX Complex via Receptor-Mediated Endocytosis. | Hyaluronic acid (HA) is not only biocompatible, biodegradable, stable in vivo, nontoxic, and non-immunogenic, but also specifically binds to the cluster of differentiation 44 (CD44) receptor, which is overexpressed in many solid tumors. Therefore, we investigated unmodified HA as a drug carrier. In this study, protopor... |
41958080 | The GPCR Connection: Linking Alzheimer's Disease and Glioblastoma. | Alzheimer's disease (AD) and glioblastoma multiforme (GBM) are biologically distinct age-related brain disorders with opposing clinical phenotypes. AD is characterised by progressive neurodegeneration and cognitive decline, whereas GBM is characterised by aggressive cellular proliferation and a poor prognosis. Despite ... |
41957672 | PLA-Derived High-Barrier Slow-Release Antibacterial Film: Industrial-Scale Preparation and Enhanced Preservation of Salmon. | This study developed an industrially scalable, fully bio-based multilayer film for sustainable packaging of high-fat aquatic products. The film combines high barrier properties with long-acting antimicrobial function through a tailored structure: Outer polylactic acid (PLA)/poly (butylene adipate-co-terephthalate) (PBA... |
41957544 | Human cGAS Drives LINE-1 Transcriptional Activation to Trigger MAVS-Dependent Cellular Senescence. | Long interspersed nuclear element 1 (LINE-1 or L1) retrotransposons pose a significant threat to somatic genomic integrity and are a source of sterile inflammation. Consequently, L1 activity is stringently controlled by multiple regulatory layers to ensure silencing, while its transcriptional derepression is linked to ... |
41957532 | Structure- and Ligand-Based Discovery of Novel 3-Chymotrypsin-Like Protease Nonpeptidomimetic Hits. | The SARS-CoV-2 3-chymotrypsin-like (3CL<sup>pro</sup>) protease is a key target for the development of COVID-19 therapeutics. While ensitrelvir and nirmatrelvir are approved drugs for treatment, the continuous research and development for new antiviral drugs is necessary to combat the emergence of variants and other re... |
41954226 | Molecular Interactions of Precocene Derivatives in Crystal Structures and in Silico Evaluation of Their Binding to Estrogen Receptors. | Crystallographic studies of potential bioactive compounds provide insight into the mode of molecular recognition and the nature of intermolecular interactions responsible for receptor-binding. Bischromans, which are dimers of precocenes, have structural similarity with 17β-estradiol and are promising estrogen receptor ... |
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