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41978108 | Biological Activity of Hops (<i>Humulus lupulus</i> L.): Molecular Mechanisms and Significance for Human Health-A Review. | <b>Introduction/Objective:</b> Common hop (<i>Humulus lupulus</i> L.) is a multi-component plant material that has been extensively studied for its antioxidant, anti-inflammatory, cardioprotective, metabolic, neuroprotective, immunomodulatory and anti-cancer properties. This review summarises current data on the molecu... |
41978103 | Diet, the Gut Microbiome, and Estrogen Physiology: A Review in Menopausal Health and Interventions. | Menopause represents a key transitional phase in women's health, characterized by declining estrogen levels and increased risk for cardiometabolic, musculoskeletal, and urogenital disorders. Beyond its endocrine roots, emerging evidence highlights the gut microbiome as a critical modulator of systemic hormonal balance.... |
41977675 | Genome-Wide Linkage Mapping for Mixograph Properties in Common Wheat. | Mixograph properties represent important quantitative traits that are controlled by multiple genes and influenced by environmental factors. In this study, we conducted quantitative trait locus (QTL) mapping for key Mixograph paraments using a recombinant inbred line (RIL) population derived from a cross between Yangxia... |
41977679 | Characterization of the Soybean <i>GmCCS-GmCSN5B-GmVTC1</i> Pathway and Its Functional Roles Under <i>Soybean mosaic virus</i> Infection. | <i>Soybean mosaic virus</i> (SMV) is a major constraint on global soybean (<i>Glycine max</i> (L.) Merr.) production, causing substantial economic losses worldwide. Despite these losses, the potential of resistance genes as a solution remains largely unexplored. In this study, the COPPER CHAPERONE FOR SUPEROXIDE DISMUT... |
41977553 | A Comparative Study of Molecularly Imprinted Polypyrrole Architectures for Electrochemical Quartz Microbalance-Based Method Development for Geraniol Adsorption. | Molecularly imprinted polymers (MIPs) are widely employed for selective adsorption of target molecules in sensing and separation applications. The architecture of MIP films can influence adsorption behavior, interfacial stability, and reusability, yet systematic investigations of these effects are limited. This study a... |
41977546 | Lamellar Dilation in (AB)-g-A Copolymacromer Melts: A Dissipative Particle Dynamics Study. | Homopolymer addition is a widely used strategy to dilate the microdomain spacing of block copolymers, yet the attainable dilation is often limited by macrophase separation in conventional blends at elevated homopolymer loading. In this work, we investigate an architectural route to suppress macrophase separation while ... |
41977221 | siRNA Nanoparticle Delivery Strategies and Clinical Trial Advances in Tumor Therapy. | siRNA, as a precise, specific, and highly effective gene-silencing therapy, has been extensively studied. Before reaching tumor cell targets, siRNA formulations must overcome multiple extracellular barriers, including clearance from the bloodstream, membrane impermeability, capture by the mononuclear phagocyte system (... |
41977214 | Bioactivities of <i>Alchemilla alpina</i> L. Extract on Women's Reproductive and Metabolic Health: Antioxidant, Enzyme Inhibitory, Receptor Modulatory Properties and Potential Cytotoxic Effects. | <i>Alchemilla alpina</i> L. (Rosaceae), belongs to a genus well recognized in traditional medicine for treating gynecological disorders and hormonal imbalance; however, the specific bioactivity of <i>A. alpina</i> itself remains poorly characterized. This study aimed to elucidate the phenolic composition and the biolog... |
41977209 | From Synthesis to Mechanism: Biological Evaluation of a p-Toluidine-Based Thiazolidinone-Quinoline VEGFR-2 Candidate Supported by CADD. | In response to recent advances in computer-aided drug discovery (CADD) enabled by high-performance computing, computational approaches were employed to support and rationalize the investigation of a VEGFR-2-targeted anticancer candidate, combining molecular-level modeling with experimental validation. Initial in silico... |
41977205 | The Multifunctional Roles of Aquaporins in Tumors: Focusing on Metabolism, Migration, and Regulation of the Tumor Microenvironment. | Aquaporins (AQPs) are transmembrane channel proteins that transport water and small solutes. Their dysregulation in cancer reveals functions beyond maintaining osmotic balance. This review summarizes that AQPs drive tumor progression through three core mechanisms: metabolic reprogramming, enhanced motility, and remodel... |
41977203 | Strategies for Photoelectrochemical Splitting of Water. | The photoelectrochemical splitting (PEC) of water provides a direct route to converting solar energy into storable chemical fuels. When illuminated, a semiconductor photoelectrode can absorb light and generate electron-hole pairs, which participate in interfacial redox reactions at the semiconductor-electrolyte junctio... |
41976850 | The Importance of the "Damage Control" Strategy in Multiple Organ Injuries, Pathophysiology and Principles of Hemorrhage Control. | <b>Background/Objectives</b>: Damage Control Resuscitation (DCR) is a critical strategy in the management of severe trauma, focusing on the optimisation of the patient's physiological condition. This study reviews current DCR strategies, emphasizing the mitigation of the "diamond of death"-hypothermia, acidosis, coagul... |
41976835 | Dry Eye Disease: From Mechanisms to Management and Future Directions. | Dry eye disease (DED) is a complex, multifactorial, progressive disease that has consequences both for individuals and society. Symptoms reported by patients include discomfort in the eye and periodic blurred vision, while in the broader perspective, the disease is associated with economic burdens and challenges for he... |
41976614 | Rationally Designed PU/CNFs/ZIF-8/PANI Composite Foams with Enhanced Flexibility and Capacitance for Flexible Supercapacitors. | Benefiting from their outstanding porosity, considerable specific surface area, and natural flexibility, cellulose nanofibers (CNFs)/MOF materials have emerged as competitive candidates for advanced flexible energy storage devices. However, conventional CNFs/MOFs aerogels or films often suffer from poor recoverability ... |
41976605 | Self-Assembly and Crystal Structure of Boc-Protected Dipeptides Containing L-Phenylalanine and L-Tyrosine. | The self-assembly of a novel synthesized chiral dipeptide, Boc-p-nitro-L-phenylalanyl-tyrosine, into supramolecular structures is investigated by optical absorption and photoluminescence spectroscopy as well as single crystal X-ray diffraction. The compound is a diphenylalanine derivative belonging to a family of aroma... |
41976307 | FcγRIIIA Genotype in Plasma Cell Dyscrasias Is Associated with Clinical Progression, Bone Disease Extension and Immune Dysfunction. | <b>Background/Objectives</b>: FcγRIIIA presents a single nucleotide polymorphism at position 158 (V/F), which affects its binding affinity to the fragment crystallizable (Fc) of antibodies (Abs). In the presence of immune complexes, FcγRIIIA can mediate the inflammatory signaling, severity of bone disease, and osteocla... |
41976302 | Tumor Microenvironment in Neuroblastoma and Immunotherapeutic Approaches: Towards More Effective Treatment. | <b>Background/Objectives</b>: High-risk neuroblastoma (HR-NB) is a major cause of cancer-related death among children. The review aims to discuss various biochemical and genetic traits of neuroblastoma (NB) used for the potential of cell-based therapies. <b>Methods</b>: A comprehensive search was performed through MEDL... |
41976299 | Membrane Curvature and Cancer: Mechanisms, Implications, and Therapeutic Perspectives. | Membrane curvature is a fundamental biophysical property of cellular membranes that underlies essential processes such as vesicle formation, organelle shaping, intracellular trafficking, and membrane scission. While traditionally studied in the context of cell biology and membrane dynamics, membrane curvature is now em... |
41976135 | Anthraquinones Inhibit Insulin Amyloidosis in Crowded Environments. | Natural anthraquinones possess a wide range of biological activities, including antibacterial, antiviral, antitumor, and antioxidant effects. However, studies on their ability to inhibit amyloid protein aggregation remain relatively limited. In this study, we used insulin as a model protein to investigate the anti-amyl... |
41976129 | Connectivity-Rewired Construction of Hydrogen-Bonded Azo-Macrocycles Enables Photoswitchable Recognition of Lithium Ions. | Photoresponsive hydrogen-bonded azo-macrocycles capable of selectively recognizing lithium cation were constructed by reversing the amide-azobenzene connectivity, which redistributes electron density and preorganizes four carbonyl oxygen donors into a smaller, more convergent cavity. Compared with a connectivity-isomer... |
41976125 | Single-Molecule Color-Stable Cool-WOLED Emitters with Multicolored Emission. | Single-molecule white-light emitters have attracted much attention due to their potential applications in white organic light-emitting diodes (WOLEDs). Their key advantage lies in the ability to use a simple device structure, akin to that of monochromatic OLEDs, to produce WOLEDs. This approach not only simplifies the ... |
41972680 | Nanoparticle-Induced Breast Cancer Cell Death: The Associated Mechanisms of Seven Major Cell Death Pathways in Preclinical Models and a Cross-Validation Model. | Breast cancer is among the most common forms of cancer in women worldwide and continues to be a major challenge in medical science and clinical care because of the complexity of its biological nature and common resistance to treatment. Nanoparticles for treating breast cancer are becoming a new-generation approach to i... |
41972615 | Chiral Self-Assembly and Chiral Separation of Ext-TEB Molecules on Bi(111). | The two-dimensional chiral self-assembly and chiral separation of achiral Ext-TEB molecules on a Bi(111) surface were investigated using low-temperature scanning tunneling microscopy (LT-STM). At low coverage, the molecules self-assembled into chiral clusters. As the coverage increased, a monolayer film with a non-edge... |
41972173 | Targeted drug delivery systems for pancreatic cancer therapy: advances, challenges, and future perspectives. | The review summarizes recent advances, challenges, and future perspectives in targeted drug delivery systems (DDSs) for pancreatic cancer (PC) therapy. Given the dismal prognosis of PC treatment is hindered by a dense desmoplastic stroma, profound hypoxia, limited T-cell infiltration, and abundant immunosuppressive mye... |
41972163 | CD24 as an innate immune checkpoint in solid tumors: biology, biomarker stratification, and therapeutic translation. | CD24 is a glycosylphosphatidylinositol-anchored surface protein frequently overexpressed in solid tumors and increasingly recognized as an innate immune checkpoint that suppresses macrophage-mediated phagocytosis through engagement of Siglec-10 in humans (Siglec-G in mice). Beyond its associations with tumor aggressive... |
41971453 | Natural product-induced apoptosis in oral squamous cell carcinoma via targeting mitochondrial multifunctionality. | <h4>Background</h4>Mitochondria, as the regulatory center of cellular energy metabolism, can influence ATP synthesis, redox balance, and apoptotic pathways. Recent studies have confirmed that some natural products, due to their self-assembling properties and multi-target effects, can inhibit OSCC progression by regulat... |
41971326 | Evolutionary trajectory and co-infection dynamics of human influenza A(H1N1) virus (2000-2025): an integrated framework informed by expert-informed bibliometrics. | <h4>Introduction</h4>Influenza A (H1N1) remains an important seasonal respiratory pathogen, but evidence on its evolutionary dynamics, reported co-detections, and surveillance priorities remains fragmented.<h4>Methods</h4>We conducted an evidence-mapping synthesis (2000-2025) integrating bibliometric analysis, expert-g... |
41971084 | <i>Sodium New Houttuyfonate</i>: a comprehensive review of pharmacological advances in antimicrobial, antitumor, and adjuvanticity effects. | <i>Sodium New Houttuyfonate</i> (SNH) is a structurally modified derivative of <i>Houttuynia cordata Thunb.</i>, emerging as a promising multi-target agent with potential applications in antimicrobial, antitumor, and adjuvant therapies. Here, we present the first review comprehensively summarizing recent pharmacologica... |
41971023 | CAU-10-H: Synthesis Scale-Up at the Pilot Scale, Techno-Economic Analysis, and Application in a Full-Scale Cooling System. | Metal-organic frameworks (MOFs) offer a wide range of advantages for modern society. In particular, the growing societal challenges of energy consumption for cooling and water scarcity can be addressed by high-performance MOFs, such as CAU-10-H, Al-MIL-160, and MOF-303. To enable the application of MOFs, sustainable an... |
41970952 | Histone methyltransferase G9a crosstalks with H3K36 histone methyltransferases NSD3 and SETD2 to mediate gene activation. | The euchromatic histone methyltransferase G9a/KMT1C/EHMT-II functions as a corepressor and a coactivator of transcription, depending upon its association with distinct protein complexes. While the mechanisms of G9a-mediated repression are well understood, the molecular mechanism of G9a-mediated activation remains elusi... |
41970927 | Boosting Stabilized Pickering Emulsion via Janus Materials for Efficient Interfacial Photoreforming Hydrogen Evolution. | Interfacial photocatalysis has been developed; however, in liquid-liquid heterogeneous systems, photocatalytic efficiency remains limited by stability and mass transfer constraints. To address the challenges, we constructed a Pickering emulsion (PE) system stabilized by Janus-structured amphiphilic TiO<sub>2</sub> nano... |
41970900 | Efficient Fluoride Removal by Ce-MOFs and Ce/Mg MOFs: A Mechanistic Investigation. | Adsorption is a highly effective method for eliminating excess fluoride from water. However, conventional adsorbents are constrained by limited adsorption capacities, subpar interference resistances, and low regeneration efficiencies. To overcome these limitations, this study adopts a one-pot synthesis method for the r... |
41970815 | Exploiting Activated Carbon Felt as a Selective Adsorbent for Removal of CO<sub>2</sub> from Methane in a Pressurized Fixed-Bed Column. | This work investigates commercial activated carbon felt (ACF) as a selective adsorbent for CO<sub>2</sub> separation from methane in pressurized fixed-bed columns, for potential use in off-shore natural gas purification. Pristine ACF was chemically modified, aiming to improve its adsorption capacity, followed by compre... |
41970394 | Nanomaterials in osteoarthritis therapy: advances in drug delivery, tissue regeneration, and implant engineering. | Osteoarthritis (OA) is a progressive degenerative joint disorder characterised by cartilage destruction, subchondral bone alterations, and chronic inflammation. Existing therapeutic interventions primarily provide short-term relief but fail to repair damaged tissues. Nanotechnology has emerged as a potential solution t... |
41970243 | The pharmacological effects and therapeutic potential of flavonoids in digestive diseases. | <h4>Background</h4>Digestive system diseases remain highly prevalent globally and constitute a major cause of mortality and disability. They not only severely compromise individual health but also result in massive consumption of medical resources, exacerbating socioeconomic burdens, thus emerging as a critical global ... |
41970233 | Synthesis and host-guest chemistry of a thiophene-extended pillar[6]arene: toward applications in nitroaromatics removal and cell imaging. | Over the past decade, significant progress has been made in the study of pillar [n]arenes; however, the development of their analogs remains underexplored, offering new opportunities for the discovery of functional materials. In this work, a luminescent thiophene-extended pillar [6]arene (<b>TPExP6</b>) featuring a π-r... |
41970227 | Enhancing the delivery and stability of lipid nanoparticle-dsRNA formulations in the RNAi-recalcitrant fall armyworm (<i>Spodoptera frugiperda</i>). | The fall armyworm (FAW, <i>Spodoptera frugiperda</i>) is an invasive lepidopteran pest of staple crops. Its broad host range, ability to spread rapidly, and increasing resistance to pesticides pose a major threat to global food security. RNA interference (RNAi) offers a sustainable and targeted alternative to broad-spe... |
41969530 | Cancer metastasis <i>in vitro</i> models - can 3D biofabrication and microfluidics sow the seeds in the right soil. | More than 140 years after the first observations that cancer cells spread to secondary sites nonrandomly, the lack of representative pre-clinical models of metastasis precludes our understanding of the processes of metastasis. The development of new 3D biotechnologies, biomaterials, tissue engineering and more intricat... |
41969525 | Neuropeptide and cytokines expression in long COVID-19 related neuropsychological sequelae: insights into NK1R-mediated neuroinflammation and <i>in silico</i> therapeutic targeting. | <h4>Background</h4>Long COVID-19 causes neurophysiological, cardiopulmonary, and musculoskeletal issues. Increased neuropeptides and cytokines lead to neuroinflammation, resulting in neurocognitive impairments, fatigue, depression, anxiety, and severe cognitive deficits. The Neurokinin 1 receptor (NK1R) is a cellular r... |
41960145 | Combined single-cell transcriptome and Mendelian randomization to identify and validate prognostic genes associated with endoplasmic reticulum stress and butyrate metabolism in lung adenocarcinoma. | <h4>Background</h4>Lung adenocarcinoma (LUAD) is a prevalent and aggressive subtype of lung cancer, with a 5-year survival rate below 20% due to late-stage diagnosis and drug resistance. Endoplasmic reticulum stress (ERS) and butyrate metabolism (BM) play critical roles in tumor progression, but their co-regulatory fea... |
41955666 | Ultra-high field solid-state NMR of microporous materials at 1 GHz and beyond: A mini review. | Microporous materials, including zeolites and metal-organic frameworks (MOFs), play pivotal roles in a wide range of applications such as catalysis, gas adsorption/separation, drug delivery, and chemical sensing. Establishing their structure-property relationships requires detailed characterization of local structures.... |
41952666 | SERS and SEF with enhancement in nanogaps: from fabrication to biosensing. | This review surveys SERS and SEF spectroscopies, with a spotlight on the correlation between nanogap fabrication techniques and subsequent applications of those nanogaps in biosensing. In the last several decades, the development of new nanofabrication techniques and novel applications substantially increased the impor... |
41931871 | Surveillance and cross-species transmission assessment of H3NX avian influenza viruses isolated in Guangdong province, China from 2023 to 2025. | Continued influenza surveillance remains important, especially given that the emergence of novel subtypes or reassorted influenza viruses with pandemic potential continues to be a worldwide threat. In particular, virus circulating in birds can facilitate interspecies transmission to humans. In this study, we conducted ... |
41930767 | Nanocarriers in Alzheimer's Therapy: A Comprehensive Review on Nanoparticulate Drug Delivery Systems. | <h4>Introduction</h4>Neurodegenerative disorders, particularly Alzheimer's Disease (AD), pose a major global health challenge, characterized by progressive neuronal degeneration and cognitive decline. The blood-brain barrier (BBB) significantly limits the efficacy of conventional therapeutics, preventing adequate drug ... |
41930322 | Nanobody-Mediated c-MYC Degradation Inhibits Tumor Cell Progression. | The c-MYC oncogene, a critical driver of malignancies, is frequently associated with poor prognosis because it promotes unchecked cell proliferation and alters gene expression. Effective targeting of c-MYC using conventional therapeutic strategies has been difficult, largely because of its unstructured nature. In the p... |
41928684 | Advances in Polymeric Drug Delivery Systems: From Biodegradability to Nanocarrier Technologies. | Research studies indicate that biodegradable polymers play a crucial role in effective drug delivery, helping to manage drug release and decreasing potential toxic reactions. It thoroughly reviews different types of biodegradable polymers, the ways they are produced, and how they work for releasing drugs. The article b... |
41924811 | Precise thermal regulation of defect and coordination structures in carbon nitride govern divergent photocatalytic activities. | Graphitic carbon nitride prepared through supramolecular prepolymerization and molten-salt strategies has shown strong potential in photocatalytic hydrogen evolution and pollutant degradation. In this work, we integrate these two approaches to construct single-atom-anchored carbon nitride (NaK-CN) and demonstrate that ... |
41924448 | Biomimetic Nanoparticles for Bone Regeneration: Construction Strategies and Therapeutic Mechanisms. | Bone tissue is the hardest and most dynamic connective tissue in the human body, and its integrity is essential for maintaining both mechanical support and physiological functions. However, with the aging population, the incidence of fractures, osteoporosis, and bone defects has risen significantly, severely impairing ... |
41921325 | Selective removal of trace 2-methylisoborneol in real waters via hydrophobic interface-driven adsorption. | Taste-and-odor episodes caused by 2-methylisoborneol (2-MIB) remain a persistent challenge for drinking water utilities because effective removal must be achieved at trace concentrations under complex natural organic matter interference. Here, a rationally designed hydrophobic metal organic framework (MOF) adsorbent, M... |
41918966 | Antimicrobial Peptides as Novel Ecological Approaches to Caries Prevention. | Antimicrobial strategies have consistently been a central theme in caries prevention research. Due to their potent antibacterial properties and the potential for multifunctionality through sequence modification, antimicrobial peptides (AMPs) are emerging as promising candidates for anticaries therapeutics. Traditional ... |
41909800 | A turn-on AIE sensor for nanomolar detection of perrhenate in aqueous media. | The "light-switch" Ru(ii) polypyridine complexes have been developed as a novel fluorescent sensor for rapid and sensitive detection of ReO<sub>4</sub> <sup>-</sup> anions in pure aqueous media. When counterions (Cl<sup>-</sup>) in aqueous solution are specifically exchanged by ReO<sub>4</sub> <sup>-</sup> anions, the ... |
41909795 | Carrier-free self-assembled nanomedicines from natural small molecules: advances and perspectives for disease treatment. | Carrier-free self-assembled nanomedicines (CFSNs) derived from natural small molecules (NSMs) have garnered significant attention in the field of nanomedicine due to their unique properties and potential therapeutic applications. This review provides an in-depth analysis of the recent advances in the development and ap... |
41909192 | Toxic effects of microplastics in aquatic environments and the pathways to sustainable management. | Environmental hazards caused by untreated synthetic polymer wastes, which are harmful to the environment after being gradually broken down into microsized particles through a number of processes. Many studies focusing on microplastics (particle sizes ranging from 1 to 5 mm) have been published. Recent discoveries of mi... |
41909186 | Carbon nanotube integrated MOF-derived ZnCo<sub>2</sub>O<sub>4</sub>: a nanohybrid electrochemical platform for riboflavin sensing. | Metal-organic framework (MOF) derived spinel metal oxides have attracted significant interest as electrochemical transducers due to their high surface area, rich redox-active sites, and tunable porous architectures. A nanohybrid sensing platform based on MOF-derived ZnCo<sub>2</sub>O<sub>4</sub>, integrated with multi-... |
41908629 | Negative cooperativity in the formation of two H-bonds with an oxygen H-bond acceptor. | Cooperative effects in H-bond networks can be quantified by measuring the effect of an intramolecular H-bond on the association constant for formation of a second intermolecular H-bond with the same functional group. This approach has been used to quantify the cooperativity associated with the interaction of a phosphor... |
41908585 | Introduction to "Endocytosis and cellular delivery". | Alexander Kros, Georgina Such, and Vincent Rotello introduce the <i>RSC Pharmaceutics</i> and <i>RSC Chemical Biology</i> themed collection on Endocytosis and cellular delivery. |
41905217 | Bioactive hydroxyl-terminated phosphorus dendrimers mediate protein/drug co-delivery for enhanced multi-target ischemic stroke therapy. | The treatment of ischemic stroke (IS) faces significant challenges due to the complex pathophysiology, which encompasses oxidative stress, neuroinflammation, and blood-brain barrier (BBB) dysfunction. Here, we report the development of a bioactive per se hydroxyl-terminated phosphorus dendrimer-based nanoplatform for p... |
41905038 | Au NPs-Induced ligand-defective Ce MOF boosting oxidase-like activity for colorimetric aptasensor platform construction. | In this study, Au NPs were substituted for a H<sub>2</sub>BDC ligand on the Ce MOF, resulting in ligand-defective Au@Ce MOF. The coordination environment of the cerium metal sites is effectively disrupted, leading to the formation of electron-enriched Au-O-Ce interface. It results in reduction of the electron density o... |
41902404 | A cationic single-chain bolalipid forms stable vesicles with distinct interfacial behavior. | The ability of single-chain bolalipids (or bolaamphiphiles) to self-assemble into vesicular structures remains poorly characterized. Here, we report the synthesis and self-assembly behavior of a new class of proline-based single-chain lipids, a symmetric bipolar molecule (2Pro-C18:1) and, for comparison, a unipolar ana... |
41886406 | Mapping the rare disease stakeholders in India. | Rare diseases (RD) are not rare collectively, affecting around 300 million people globally and 96 million in India. These diseases have not been prioritized in most low- and middle-income countries' health policies. India launched its first functional RD policy in 2021. Successful policy implementation requires the act... |
41886289 | Metal-Organic Framework-Based and Humidity-Tolerant Quartz Crystal Microbalance Sensor for Difluoromethane Refrigerant Leak Detection. | The need for low-cost refrigerant leak detection sensors is crucial for the rapid adoption of next-generation refrigerants. A metal-organic framework (MOF)-based quartz crystal microbalance (QCM) sensor was used for the detection of difluoromethane (R32). Initially, five well known MOFs, MIL-101, HKUST-1, MOF-74, UiO-6... |
41886128 | Characterization of neocentromeric marker chromosome derived from chromosome 11: a rare entity in four patients with acute leukemia. | Neocentromeres are newly formed chromosomal regions that can replace the function of traditional centromeres and are well documented in human clinical studies. However, their occurrence in neoplasia, including acute leukemia, appears to be rare. We analyzed complex karyotypes in bone marrow cells from 113 patients with... |
41886135 | Optimisation of electrospinning parameters to successfully obtain high ratios of medium chain length polyhydroxyalkanoate in electrospun fibres with drug loading for wound healing applications. | Chronic wounds, burns and ulceration of dermal and mucosal tissues are extremely common and can arise for a wide variety of reasons causing extreme pain and reducing patient quality of life. Current treatment regimens involve the use of topical corticosteroids for prolonged treatment periods. Due to issues surrounding ... |
41889178 | Designing Tailored Molecular Cavities Using Calix[5]arenes as Building Blocks. | This study examines the shapes and dimensions of cavities defined by well-designed molecular structures. We discuss our work on creating custom cavities using calix[5]arenes. The shapes and dimensions of these cavities are precisely determined to selectively interact with specific guest molecules. We demonstrate that s... |
41889159 | Self-Assembly Behavior of Amino Acids on Au (111) Surfaces: A Molecular Dynamics Study. | The emerging amino acid nanostructures provide a new type of smart biomaterial for biomedical applications. However, the lack of mechanistic understanding of their temperature-dependent self-assembly on inert solid surfaces limits the rational design of the desired nanostructures. Herein, we report different monolayer ... |
41889143 | Metabolic Glycoengineering of Synthetic "Membrane Receptors" via Supramolecular Host-Guest Recognition. | Metabolic glycoengineering enables the installation of unnatural chemical motifs on cell-surface glycoconjugates by leveraging endogenous biosynthetic pathways, yet prior efforts have primarily emphasized covalent chemistries. In this work, high-affinity supramolecular recognition motifs are introduced onto mammalian c... |
41889088 | Fluorine-Driven Polychromatic Colorimetric Screening of PFAS via Iodide-Mediated Gold Nanorod Etching on a Dual-Ligand Cu-MOF: A "No Aggregation, Low Inhibition" Sensing Paradigm. | Developing hue-tunable polychromatic colorimetric sensors for perfluoroalkyl and polyfluoroalkyl substance (PFAS) detection offers significant advantages over conventional monochromatic systems, particularly in terms of improving visual readability and on-site applicability. Herein, inspired by classical iodometric tit... |
41889071 | A Complex Cubic Liquid-Crystalline Phase Self-Organized from Five Differently Distorted Supramolecular Globular Dendrimers. | Previously our laboratory reported complex helical columnar, cubic, tetragonal, and liquid quasicrystal periodic and quasiperiodic functional helical arrays (including homochiral) self-organized from supramolecular dendrimers. They have attracted the interest of theoreticians and have been discovered in many other area... |
41888520 | Prediction of strong Cu(I)-He interaction at open metal sites enables isotope-selective helium adsorption. | Helium is generally known as an inert element due to its high ionization potential, zero electron affinity, and low polarizability. Here, we demonstrate that Cu(I) sites with favorably coordinated ligands reach unexpectedly large He binding energies, up to 19 kJ mol<sup>-1</sup>, due to He polarization and charge accum... |
41888226 | Integrated DFT, molecular docking, and molecular dynamics investigation of some novel 2-thiohydantoin analogues as potent CDK2 inhibitors for anticancer therapy. | Cancer progression is driven by dysregulation of cyclin-dependent kinase 2 (CDK2), a critical cell cycle regulator. This study employed an integrated computational approach combining Density Functional Theory (DFT), molecular docking, molecular dynamics (MD) simulations, and MM-PBSA calculations to evaluate 2-thiohydan... |
41888191 | Molecular recognition and induced dimerization of hnRNP A2/B1 truncations by G-quadruplex single strand DNA. | Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) is a multifunctional nucleic acid metabolism regulator with established roles in viral infection and tumorigenesis. However, a critical gap exists between the oligomeric state of hnRNP A2/B1 and its function as a nuclear DNA sensor. To address this gap, we gen... |
41888178 | Enhanced stability and reusability of metagenomic laccase via immobilization on functionalized mesoporous silica for antibiotic contaminant removal. | The extensive application of tetracycline antibiotics in agriculture and medicine has led to persistent contamination of aquatic and terrestrial ecosystems, disrupting microbial communities and contributing to the spread of antibiotic resistance. Conventional treatment methods often suffer from poor efficiency, limited... |
41888132 | DNA affects the phenotype of fuel-dependent coacervate droplets. | Synthetic cells emulate fundamental biological behaviors, like growth, metabolism, and mobility, but have lacked genotype-driven selection, which is essential for Darwinian evolution. Here, we introduce libraries of short DNA sequences as genotypes into fuel-dependent peptide-RNA-based coacervate droplets, serving as s... |
41887796 | Ca<sup>2+</sup>-Driven Protein Compaction Tunes NIR Absorption in the Thermophilic Purple Bacterial LH1. | The Ca<sup>2+</sup>-binding light-harvesting 1 (LH1) complex from the thermophilic purple phototrophic bacterium <i>Thermochromatium tepidum</i> exhibits an unusually redshifted absorption at 915 nm. To establish how Ca<sup>2+</sup> regulates spectral tuning, we employed a multimer exciton model incorporating charge tr... |
41887203 | Cationic Nanogel Coated Norovirus VLP Nasal Vaccine Induces Neutralizing Mucosal IgA and Serum IgG Antibodies. | Although norovirus can affect people of any age, the majority of deaths and illnesses occur in children under one year old and people over the age of 55. Currently, there is no vaccine or medication available. Previously, we developed a nasal vaccine drug delivery system (DDS) for a small protein antigen by using catio... |
41887201 | Light-Driven Supramolecular Pumping by Changing Shape Complementarity. | Protein pumps in the cell membrane are capable of actively moving solutes uphill to build concentration gradients, a process pivotal to biological energy conversion. These pumps dissipate light or chemical energy to generate and maintain a nonequilibrium steady state. Achieving continuous unidirectional displacement of... |
41886626 | Stabilizing Structural Transitional States between 1- and 2-Dimensional Topologies via Hydrogen Bond-Mediated Crystal Engineering. | Metal-organic chalcogenolates (MOChas) are hybrid materials composed of metal-chalcogenide networks coordinated by organic ligands, offering a versatile platform for structural and electronic tunability. The use of molecular ligand design to steer material formation represents a powerful strategy for accessing new soli... |
41886618 | Fully Reduced Cu<sup>I</sup>{P<sub>4</sub>Mo<sub>6</sub>}<sub>2</sub> Supramolecular Architectures for Ultraselective Photoelectrochemical Detection of Cr(VI). | The sensitive and selective detection of toxic Cr(VI) depends on the development of high-performance photoelectrochemical sensing materials. Herein, two supramolecular architectures of Cu<sup>I</sup>{P<sub>4</sub>Mo<sub>6</sub>}<sub>2</sub>-based phosphomolybdates, with formula of (H<sub>2</sub>bib)<sub>3</sub>Pb{Cu<su... |
41886102 | Mixed modes of satellite DNA and transposable element evolution, which shape the repetitive landscape of air-breathing catfishes (Clarias). | Repetitive DNA is a major organization component of eukaryotic genomes; however, its evolutionary dynamics in teleosts remain insufficiently understood. Catfish of the family Clariidae provide a valuable model for studying the evolutionary process of repetitive DNA sequences, owing to their genomic diversity and comple... |
41886040 | Highlight selection of radiochemistry and radiopharmacy developments by editorial board. | <h4>Background</h4>The Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biannual highlight commentary to update the readership on trends in the field of radiopharmaceutical development and application of radiopharmaceuticals.<h4>Main body</h4>This selection of highlights provides commentary on 25 differ... |
41885715 | Light-Assisted Akamptisomerization: Excited-State Bond-Angle Reflection (ESBAR) as a Molecular Photoswitching Element in B<sub>2</sub>OF<sub>2</sub>-Porphyrins. | Akamptisomerism arises from bond-angle reflection (BAR) at a B-O-B bridge in low-symmetry B<sub>2</sub>OF<sub>2</sub> porphyrins and leads to isolable diastereisomers in the ground state. Herein, we present the first theoretical investigation of the excited-state bond-angle reflection (ESBAR). TD-DFT calculations show ... |
41885597 | Spin Alignment in Cr-W-Cr Motif Promotes <i>N</i>, <i>N</i>-Dimethylformamide Electrosynthesis from Dimethylamine Self-Coupling. | Formamides are indispensable building blocks in pharmaceuticals and fine chemicals, yet their sustainable synthesis remains challenging. Herein, we present the first electrochemical strategy for the direct synthesis of <i>N</i>,<i>N</i>-dimethylformamide (DMF) via dimethylamine (DMA) self-coupling, eliminating the need... |
41885448 | PROTACs in cancer therapy: targeted degradation of GPX4, PARP and epigenetic regulators. | The degradation of overexpressed proteins has emerged as a promising strategy for halting disease progression, particularly in cancer. Traditional small-molecule drugs often face limitations in the elimination of pathogenic proteins, leading to the development of targeted protein degradation (TPD) approaches. A promine... |
41885430 | Highly Water-Stable Uranyl-Cluster Based Metal-Organic Framework for Thermal Adaptive Scintillator. | In recent years, uranium-based metal-organic frameworks (MOFs) have garnered particular attention due to the accessible 5f orbitals and diverse coordination geometries of the U atom, as well as the tunability and functionality inherent to MOFs. Herein, we report a 2D-MOF (UO-TTP) featuring a tetranuclear uranyl cluster... |
41885390 | SMAD4 Palmitoylation Drives a Metabolic-Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer. | Pancreatic ductal adenocarcinoma (PDAC) is characterized by frequent SMAD4 inactivation and profound lipid metabolic rewiring, yet how these processes intersect especially in SMAD4<sup>+</sup> PDAC remains elusive. Here, we identify palmitoylation as a previously unrecognized post-translational modification of SMAD4. C... |
41885300 | Linker Chemistry in Radiopharmaceutical Design. | Over the last half century, molecularly targeted bioconjugates have revolutionized nuclear medicine. An array of vectors, ranging from small molecule peptidomimetics to macromolecular immunoglobulins, has been radiolabeled with radionuclides to create probes that have been deployed in both the laboratory and the clinic... |
41885277 | Nanocolloidal Hydrogel Coatings With Multiple Functions for Antithrombogenic Biointerfaces. | Hydrogel coatings offer a promising strategy for improving the biocompatibility and functionality of medical devices. However, conventional hydrogel coatings often suffer from swelling-induced delamination, poor durability, and limited resistance to thrombosis and biological adhesion. Here, we report a nanocolloidal hy... |
41885220 | Supramolecular Assembly of Collagen-Mimetic Peptide D-Periodic Fibrils and Nanoassemblies. | The collagen triple helix assembles hierarchically into bundled oligomers, solvated networks, and fibers. Synthetic peptide assemblies, driven by supramolecular interactions, can form single triple helices through intrahelical amino acid pairs; however, the principles guiding interhelical associations into higher-order... |
41885174 | Smartly Assembled near-Micron RF-Responsive Agents Bridge Transarterial Embolization and Immunothermal Potentiation. | Hepatocellular carcinoma (HCC) remains a significant clinical challenge due to the limited efficacy of conventional treatments like surgery, radiofrequency ablation (RFA), and transarterial embolization (TAE). Here, we develop an innovative TAE and immunothermal therapy strategy based on smartly assembled near-micron l... |
41885140 | Chemical Interaction Customized Metal-Organic Framework Enables Regulated Conductive Network for Selective Superionic Conduction in Solid-State Batteries. | Solid-state batteries demand solid-state electrolytes (SSEs) that couple high ionic conductivity with high Li<sup>+</sup> selectivity and broad electrochemical stability, yet these metrics rarely coexist in processable, air-tolerant SSEs. Here, we engineer chemical-interaction-customized metal-organic frameworks (CIC-M... |
41885072 | Cavity Constriction and Chiralization of Polyaromatic Subnanotubes via Post-assembly Ligand/Metal Modification. | Late-stage modification of coordination-driven tubular and cage-like structures is a promising method to tune and alter their cavity functions yet remains difficult owing to the intrinsic instability of metal-ligand bonds against the modification conditions. Here we report polyaromatic tubes with a subnanometer-sized c... |
41885061 | High-Performance SERS Detection of Monoamine Neurotransmitters Using a Nanogap-Engineered Plasmonic Platform with Application to Human Plasma. | Norepinephrine (NE) and serotonin (5-hydroxytryptamine, 5-HT) are key neurotransmitters that regulate mood, cognition, and neurochemical balance. Abnormal levels of these molecules are linked with several neuropsychiatric disorders, underscoring the need for highly sensitive and selective detection methods. In this stu... |
41884997 | Triple-Functional Amino-Coordinated Ce-Cr MOF-on-MOF Catalyst Unifying Photocatalysis, Biocatalysis, and Photobiocatalysis for Photobiosensing Applications and Binary Dyes Removal. | Photobiocatalysis has focused on chemical synthesis, with no prior reports in sensing. In photobiocatalysis, MOFs serve as host matrices for co-immobilizing photocatalysts and biocatalysts but lack intrinsic photobiocatalytic activity. Since most MOFs are oxygen-/hetero-nitrogen-coordination frameworks, developing amin... |
41883308 | Advances in heterochromophoric perylene bisimide self-assemblies towards supramolecular electronics. | Perylene bisimide (PBI) dyes are the quintessential and most well-studied class of dyes for designing biomimetic light harvesting (LH) self-assembled systems owing to their exceptional photophysical features such as excellent absorption, high molar extinction coefficient and high fluorescence quantum yield, thermal rob... |
41883196 | CO<sub>2</sub> Conversion by a Metal-Coordinated Single Amino Acid Carbonic Anhydrase Enzyme Mimic. | The rising atmospheric concentration of carbon dioxide (CO<sub>2</sub>) is assumed to be a key factor in global climate change, requiring robust and sustainable carbon conversion technologies. While carbonic anhydrase (CA) is a highly efficient enzyme for CO<sub>2</sub> sequestration, its industrial application is limi... |
41883180 | A Substrate-Dependent Redox Catalysis of Tellurenyl Species Involving Oxidation States +I, +II, and +IV. | Neutral Te(II) species 2-(<i>t</i>BuNCH)C<sub>6</sub>H<sub>4</sub>TeCl (<b>[I]Cl</b>) as well as tellurenyl Te(II)<sup>+</sup> cations [2-(<i>t</i>BuNCH)C<sub>6</sub>H<sub>4</sub>Te][X] (X = OTf or SbF<sub>6</sub>), i.e., <b>[I][OTf]</b> and <b>[I][SbF</b><sub><b>6</b></sub><b>]</b>, exhibit a wide range of reactivity ... |
41883110 | Zirconium(IV)-Succimer Metal-Organic Framework Functionalized PVDF-HFP Membranes for Heavy-Metals Capture. | Although heavy metal contamination is an ancient problem, it remains a global concern in isolated areas. Herein, we report the design of a novel thiol-rich Zr(IV) metal-organic framework (BCM-5), assembled from meso-2,3-dimercaptosuccinic acid (Succimer), a commercially available thiol-rich metal-chelating agent used i... |
41883062 | Emergence of Anisotropic Subcompartments via Coassembly of Hierarchically Ordered G-Quadruplexes and Fluid Polylysine in Droplet-Based Compartments. | Liquid-liquid phase separation (LLPS) plays a key role in cellular organization, enabling the formation of dynamic compartments that provide spatial and temporal control over biochemical processes. Although LLPS systems are typically fluidic, recent studies have revealed that specific molecular constituents can induce ... |
41883057 | Covalent versus Dimeric Optimization of Nectin-4-Targeted Peptide Radiotracers: A Head-to-Head Comparison in Triple-Negative Breast Cancer Mice Models. | Nectin-4 is highly expressed in several malignancies, including triple-negative breast cancer, and it represents an attractive target for molecular imaging and therapy. In this study, we report the first head-to-head comparison of two structural optimization strategies for Nectin-4-targeted peptide radiotracers: peptid... |
41881998 | Formation of S- and Z-twist supramolecular micro-ropes by peptide stereoisomers. | The intertwined strand arrangement in ropes, from micro- to macro-scale, results in tensile moduli significantly higher than those of single strands. Micro-scale ropes are found in biological systems, most commonly in mechanically-rigid collagen tri-strand arrangements. While human-made macro-ropes possess either left-... |
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