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41880086 | The Neuroameliorative Effects of Enzymatically Modified Isoquercitrin and Sodium R-lipoate on the Rotenone rat Model of Parkinson's Disease. | Parkinson's disease (PD) is a neurodegenerative condition distinguished by both motor and non-motor signs. Currently, therapeutic interventions effectively mitigate motor symptoms; however, they fail to impede the progression of neurodegeneration. Enzymatically modified isoquercitrin (EMIQ) is a variant of isoquercitri... |
41879805 | UV irradiation alters TFAM binding specificity and compaction of DNA. | Mitochondria lack nucleotide excision repair; however, mitochondrial DNA (mtDNA) is resistant to mutation accumulation following DNA damage. These observations suggest additional damage sensing or protection mechanisms. Transcription Factor A, Mitochondrial (TFAM) compacts mtDNA into nucleoids and binds differentially ... |
41879799 | Selective TRPV2 Antagonists Derived from the Natural Product Piperlongumine Inhibit Cancer Cell Migration and Metastasis. | TRPV2 is the least studied member of the vanilloid TRP subfamily despite its emerging relevance in cancer metastasis, pain, and inflammation. Although several small-molecule TRPV2 modulators have been reported, including the natural products piperlongumine (PL) and cannabidiol, all lack selectivity, complicating the in... |
41879639 | Synthesis of High-Purity Porous Organic Polymers and Exploration of Their Inherent Functionality. | Porous organic polymers (<b>POP</b>s) are porous materials consisting of monomers linked by irreversible covalent bonds, are thermally and chemically stable, and can contain functional backbones at high density. Therefore, <b>POP</b>s are suitable for broad applications such as adsorbents and energy storage materials. ... |
41879636 | Exploring the Effect of Electronic Symmetry on the Hyperpolarizabilities of Co(II) and Ni(II) Coordination Complexes with Cytidine Nucleotide. | The most significant factor in the design of high-performance nonlinear optical (NLO) materials is electronic symmetry, which directly influences hyperpolarizability and second harmonic generation (SHG) response. This work presents two isostructural one-dimensional coordination complexes, {[Co<sub>2</sub>(CMP)<sub>2</s... |
41879628 | Band-gap engineering of Bi-MOFs <i>via</i> anthraquinone integration for boosting photocatalytic H<sub>2</sub>O<sub>2</sub> production over a donor-acceptor-acceptor junction. | The development of efficient photocatalysts for hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) production is hindered by rapid charge recombination and sluggish reaction kinetics. Herein, we report a novel donor-acceptor-acceptor (D-A-A) junction by integrating anthraquinone-coordinated bismuth-based metal-organic fram... |
41879563 | Light-Programmable Polyester Networks with Movable Cross-Links for On-Demand Enzymatic Degradation. | The design of sustainable materials that integrates mechanical toughness with on-demand degradability remains a central challenge in the development of materials science. Here, we present a photoresponsive polyester capable of light-regulated enzymatic degradation through movable cross-links. The material consists of a... |
41879195 | Cyclicurilarenes: Hybridizing Bambusurils with Macrocyclic Arenes. | Our cyclicurilarene receptor family has been extended by coupling of 2,4-dimethylglycoluril with bis(bromomethyl)-substituted dimethoxybenzene through nucleophilic substitution, yielding macrocycles with conformational flexibility that can adapt to different-sized substrates, resembling bambusurils. Anti/syn-configurat... |
41879173 | Amino Acids as Molecular Linchpins in the Fundamental Prebiotic Processes of RNA Copying and Vesicle Formation. | In addition to being delivered via exogenous means (e.g., chondritic meteorites and comets), amino acids are hypothesized to have been present on early Earth via Urey-Miller-type abiotic processes. They conceivably coexisted in the primordial soup with nucleotides/RNA, amphiphiles and other co-solutes, highlighting the... |
41879126 | Water-Mediated Ligand Dynamics Enable Solution-Phase Self-Assembly of Perovskite Nanocrystals Into 3D Ordered Architectures. | Conventional approaches to perovskite superlattice (SL) synthesis typically involve multi-step processing with post-synthetic treatments, which often suffer from limited control, poor reproducibility, and scalability issues. Herein, we report a one-step solution-phase protocol for the synthesis of structurally stable, ... |
41879028 | Engineering Cylindrical Macromolecular Assemblies With Zwitterionic Amino Acids for Concurrent Prolonged Circulation and Tumor Targeting. | The rational design of drug delivery systems requires strategies that address the inherent trade-off between active targeting and immune evasion. Here, we present a molecular design that integrates a zwitterionic amino acid interface with morphological control via graft polymer self-assembly enabling both functions to ... |
41879026 | Enzyme-Mediated Dissipative Hybridization Chain Reaction (HCR). | We report here a novel strategy to achieve enzyme-mediated dissipative control over hybridization chain reaction (HCR). To achieve this, we have rationally re-engineered a reversible HCR approach so that the assembly and disassembly of DNA polymers can be transiently regulated by RNA/DNA fuel strands in combination wit... |
41878871 | Circularly polarized-light-driven chiral optoelectronics: encoding, sensing, and neuromorphic processing from an information-flow perspective. | Circularly polarized light (CPL) represents an important information carrier beyond mere intensity and wavelength, encoding spin angular momentum that chiral materials can selectively manipulate. By translating molecular and supramolecular mirror asymmetry into chirality-dependent optical and electrical signals, chiral... |
41878847 | Metal Organic Framework-Based Biosensors for Healthcare and Agricultural Applications. | Metal-organic frameworks (MOFs), with tunable structures, high porosity, and catalytic activity, are promising platforms for next-generation biosensors. MOF-based nanozymes (MOFzymes) and enzyme-MOF composites combine biological specificity with synthetic robustness, overcoming limitations of natural enzymes in complex... |
41878831 | Oriented Growth of In Situ Coordinated MOF on Spherical Cu<sub>2</sub>O for Electrocatalytic CO<sub>2</sub> Reduction to Ethanol. | The electrocatalytic carbon dioxide reduction reaction (CO<sub>2</sub>RR) offers a promising approach for the conversion of carbon dioxide into valuable C<sub>2</sub> chemicals and fuels. Nevertheless, challenges persist in attaining high selectivity, stability, and yield. Dual-phase copper-based catalysts, particularl... |
41877578 | Trapping a Metastable Node in an Amorphous Metal-Organic Framework. | We report the frustrated assembly of an amorphous metal-organic framework as a route to trap a metastable node within the network. Using x-ray pair distribution function (PDF) analysis and density functional theory (DFT), we show that a distorted node forms instead of the more commonly observed and energetically favora... |
41877228 | Peptide nanofibers and PAMP agonist combinations enhance pulmonary CD4<sup>+</sup>T cell functionality of immune recall to vaccination. | Vaccine adjuvants typically contain pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs) that activate innate immune cells. The FDA's approval of multiple PAMP-DAMP combinations for clinical use has generated increased momentum in this field in recent years. Here, we report the... |
41876935 | Electrochemical sensor based on iron-based metal-organic framework nanocomposite derived from acid mine drainage for the detection of lead (II) ions in water. | Lead (Pb<sup>2+</sup>) in water poses significant health risks, which require sensitive and cost-effective detection techniques. This study addresses this challenge by presenting a novel electrochemical sensor based on Fe-alginate metal-organic framework (Fe-alg-MOF) composite. This composite was prepared by leveraging... |
41876823 | Contrasting roles of VfSBP transcription factors in regulating disease resistance and abiotic stress tolerance in faba bean. | <h4>Key message</h4>This study elucidates the functional characteristics of VfSBP4, VfSBP10, VfSBP12 and VfSBP17 under disease resistance and abiotic stress tolerance. It provides key genetic targets for the molecular breeding of stress-tolerant faba bean varieties. As an important food crop worldwide, faba bean (Vicia... |
41876789 | Development of a dispersive solid phase extraction method based on copper-metal organic framework nanoparticles for the determination of lead at trace levels in stream samples. | In this study, a facile, rapid, and cost-effective method was developed for the determination of lead ions using copper-metal organic framework (Cu-MOF) nanoparticles based dispersive solid phase extraction (DSPE) in slotted quartz tube-flame atomic absorption spectrometry (SQT-FAAS) system. Cu-MOF nanoparticles were u... |
41876472 | A comprehensive review of hydrogen sensor for thermal runaway monitoring: fundamentals, recent advancements, and challenges. | Thermal runaway (TR) in lithium-ion batteries (LIBs) remains an intrinsic safety issue, posing significant risks of fire and explosion. Among various technologies employed to assess LIB status- including temperature, pressure, voltage, and gas measurements-gas sensors exhibit superior response speed and stronger sensin... |
41823209 | Hierarchical MOF-on-MOF-structured dual-functional nanozyme for enhanced catalysis and the dual-channel detection of α-glucosidase. | Metal-organic framework (MOF)-on-MOF hybrids have garnered significant interest due to their ability to integrate multiple catalytic functions within a single nanostructure. Synergistic interactions between MOF components often yield emergent properties beyond those of individual frameworks. In this study, we develop a... |
41810497 | Supramolecular peptide hydrogel-mediated synergistic antibiotic-photothermal therapy for potent antibacterial applications. | Bacterial infection usually exacerbates inflammation and is one of the important factors impeding wound healing. At present, dressings for treating wound infections often include antibiotics, silver ions, fibers, <i>etc.</i>, but their therapeutic efficacy is still limited. To enhance antibiotic effectiveness and overc... |
41806017 | Control of site-specific deprotonation through mechanochemical interconversion of two ionic cocrystal forms of resveratrol. | In drug development, multicomponent pharmaceutical materials have become useful tools for improving the properties and efficacy of a drug. In addition to the active drug, inclusion of a second component in the solid can provide stabilization or increase solubility of the pharmaceutical. Resveratrol, an antioxidant with... |
41801146 | Quantification of cholesterol incorporation in giant unilamellar vesicles produced by a modified cDICE method. | Cholesterol is an essential component of eukaryotic cell membranes, influencing membrane packing, fluidity, and domain formation. Replicating these properties in model membranes is critical for reconstitution studies, but common emulsion-based methods for producing giant unilamellar vesicles (GUVs) fail to incorporate ... |
41789835 | Incorporation of NU-1000 into cellulose acetate membranes with preserved indoxyl sulfate adsorption. | Zirconium-based metal-organic framework (MOF) NU-1000 was successfully synthesized and exhibited the expected structural and chemical properties, confirming its suitability as an adsorbent for protein-bound uremic toxins (PBUTs). In batch experiments, NU-1000 removed approximately 53% of indoxyl sulfate (IS), correspon... |
41778785 | Design of multivalent pharmacological chaperones against Pompe disease <i>via</i> metal-free ligation. | We report herein the design of multivalent pharmacological chaperones (PCs), based on D- and L-deoxynojirimycin (DNJ), to treat Pompe disease (PD), a lysosomal storage disorder caused by mutations in the acid alpha-glucosidase (GAA) enzyme. Multivalent DNJ platforms were built on a pentaerythritol core by Copper Azide-... |
41705883 | Amino acid derived chiral thioureas: design, synthesis and applications as NMR resolving agents for enantioselective recognition. | A new class of chiral thiourea derivatives derived from amino acids have been developed that harness the dual influence of strong hydrogen bonding and stereogenic amino acid scaffolds. Both unsymmetrical (UTU) and symmetrical (STU) amino acid-based thioureas were synthesized and evaluated as molecular receptors for chi... |
42006315 | The genome landscape of Hong Kong feral cattle as a unique genetic resource. | In the Hong Kong Special Administrative Region of China, there is a feral cattle population that has not been well characterized genetically. In this study, we used high-coverage (∼30×) whole-genome sequencing from 30 Hong Kong feral (HKF) cattle and compared them to 116 individuals from four representative populations... |
42002321 | Unraveling the binding mechanism and enhanced performance of indigo/β-cyclodextrin inclusion complex: An integrated experimental and computational study. | Indigo (IN) has significant value in dyeing and potential pharmacological applications, but its poor water solubility severely limits bioavailability and processing efficiency. This study investigated the formation, structure, and binding mechanism of inclusion complexes (ICs) between IN and β-cyclodextrin (β-CD) throu... |
41993590 | Bridging bioactive metabolites of <i>Phoenix dactylifera</i> L. with advanced nanocarrier technologies for mucoadhesive drug delivery. | <i>Phoenix dactylifera</i> L. (PD), a monocotyledonous flowering plant from the Arecaceae family, is one of fourteen species in the Phoenix genus and has been cultivated in the Middle East for over 6,000 years. Its fruit is regarded as a complete food due to its rich nutritional and medicinal profile, containing flavon... |
41988307 | 3D printing as an innovative tool in personalized management of complex airway diseases: a literature review. | <h4>Background and objective</h4>Personalized medicine tailors interventions to a patient's unique anatomy and physiology. Three-dimensional printing (3DP) enables this precision for complex airway disease, including tracheal stenosis, tracheobronchomalacia, aerodigestive fistulas, and segmental defects, where conventi... |
41977651 | Terrestrial Plant- and Algal-Derived Biostimulants as Modulators of ROS and Hormone Networks in Crop Abiotic Stress Resilience. | Abiotic stresses severely constrain crop productivity by disrupting cellular redox homeostasis and hormone signaling. Although individual stresses differ in origin, plant responses converge on a conserved regulatory system centered on reactive oxygen species (ROS) and phytohormone crosstalk. Controlled ROS production i... |
41977529 | Charge Trap and Oxygen Barrier Engineering in Voltage-Stabilizing Grafted Silicone Rubber via Multiscale Molecular Simulations. | The present theoretical study proposes and unravels chemical graft modification using a novel voltage stabilizer (3-amino-5-chlorophenyl 3-fluorophenyl methanone, ACFM) to ameliorate electrical insulation performance, oxygen-resistant characteristics, and thermal stability of addition-cure silicone rubber (SiR) used fo... |
41977144 | Stem Cell-Derived Organoids for Cancer Therapy: Precision Medicine and Drug Selection. | Millions of new cancer cases and deaths worldwide annually demonstrate the pressing need for predictive preclinical models that go beyond standard two-dimensional (2D) cultures and animal systems. Recent developments in three-dimensional (3D) organoid technology have yielded a powerful platform for generating patient-s... |
41977127 | Beyond Resistance Genes: Silencing Susceptibility. | The ongoing evolutionary struggle between crops and pathogens has highlighted the limitations of resistance gene (<i>R</i> gene)-based control, which often fails due to rapid pathogen adaptation. To address this, we must look beyond R genes and explore susceptibility genes (S genes) that pathogens take over during infe... |
41977129 | Lysine Propionylation as a Metabolically Coupled PTM: Mechanisms, Functional Consequences, and Therapeutic Potentials. | Lysine propionylation (Kpr) is a metabolically coupled lysine acylation that links propionyl-CoA availability to the molecular regulation of gene expression and protein function. Although lysine acetylation (Kac) is the most extensively characterized, recent proteomic and metabolic studies suggest that Kpr is more freq... |
41977124 | Therapeutic Potential of Mulberry and Its Resilience to Abiotic and Biotic Stresses. | Mulberry is a plant species of significant economic value and is widely incorporated into various traditional medicinal formulations. Its multiple botanical parts (leaves, branches, fruits, seeds, and roots) possess both nutritional and therapeutic properties. Throughout its growth cycle, mulberry is exposed to a range... |
41976789 | Glucocorticoid-Induced Osteoporosis: Pathogenesis, the Impact of Different Administration Routes on Bone Mineral Density, and Fracture Risk and Treatment Options-A Narrative Review. | Glucocorticoids (GCs) are widely used for their potent anti-inflammatory and immunosuppressive effects, but their use is strongly associated with negative impacts on bone health. Rapid bone loss and an increased risk of fragility fractures are characteristics of glucocorticoid-induced osteoporosis (GIOP), the most comm... |
41976565 | Advanced Materials and Processing Technologies. | This reprint gathers the fourteen research articles originally published in the Special Issue of <i>Materials</i> titled "Advanced Materials and Processing Technologies" [...]. |
41971696 | Poly(ethylene furanoate) (PEF): Advances in Synthesis, Properties, Recycling, Applications, and Future Challenges. | The increasing concern over plastic pollution mostly due to extensive use of petroleum-based poly-(ethylene terephthalate) (PET) has intensified the search for sustainable biobased alternatives. Poly-(ethylene furanoate) (PEF), a fully biobased polyester derived from renewable feedstocks, has emerged as one of the most... |
41970922 | Binding of Steroid Hormones to the FA1 and FA6 Sites of Human Serum Albumin through Computational Biology and Quantum Biochemistry. | Human serum albumin (HSA) plays a significant role in the transportation of steroid hormones through noncovalent interactions of low affinity. The binding between HSA and estradiol and testosterone has been a subject of investigation through experimental tools. While some studies suggest that HSA carries sex steroid ho... |
41970878 | Self-Assembly of Alginate-Grafted Penicillanic Acid Derivatives into Antibacterial Micelles for Controlled Drug Delivery. | The self-assembly and drug release of amphiphilic polymers are critically controlled by synergistic molecular forces and polymer architecture. Therefore, elucidating the self-assembly behavior of amphiphilic polymers, based on the entropy effect mediated by water molecules, is of significant importance for designing fu... |
41970855 | Pharmacokinetic Prediction of Repurposed Drugs for PDAC Using Artificial Intelligence. | Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer that accounts for 95% of cases of pancreatic cancer. It develops in the ducts and shows high drug resistance. In this study, we proposed a framework to predict the pharmacokinetic (PK) properties of repurposed drugs for PDAC using artificial intellig... |
41970814 | Photophysical Properties of Free, Zinc‑, and Pyridine- Chlorin e6 Trimethyl Ester: A Computational Study with Vibrational Effects. | Chlorophyll derivatives, such as chlorin e6, are natural products with promising properties as photosensitizers (PS); they are highly abundant, and their extraction is a relatively straightforward process. Therefore, they serve as an ideal starting point for the rational design of new photosensitizers with enhanced pro... |
41969426 | EBV genome analysis in multiple sclerosis shows extensive viral diversity and links to autoimmunity. | Epstein-Barr virus (EBV) is a major risk factor for multiple sclerosis (MS), yet the contribution of specific viral variants remains unclear. Complete EBV genome analysis of wild-type variants has not been performed previously. In a pilot-study, targeted EBV sequencing of B cells did not yield adequate coverages due to... |
41960416 | Ruthenium-Based Defective MOFs as Heterogeneous Catalysts for the Hydrogenation of Carbon Dioxide to Formate. | The hydrogenation of carbon dioxide to formic acid has attracted considerable interest for carbon utilization and hydrogen storage. Metal-organic frameworks (MOFs), featuring open coordination sites and tunable pore structures, offer unique advantages for heterogeneous catalysis. Herein, we report the catalytic perform... |
41953680 | Emergence of multidrug-resistant ST876 serotype 14 <i>Streptococcus pneumoniae</i> with spontaneous mutations driving pathogenesis: genomic and clinical insights from pneumococcal pericarditis and global screening. | <h4>Background</h4><i>Streptococcus pneumoniae</i> pericarditis is rare and lethal, yet how the pathogen evolves within the host during blood-to-pericardium spread remains unknown.<h4>Methods</h4>Two ST876 serotype 14 strains, hz23B (blood) and hz23P (pericardial effusion), were isolated from one purulent pericarditis ... |
41953561 | Advancements in nanomaterials for the treatment and management of vascular surgeries: from drug delivery to biomedical implants. | Vascular surgery is an important procedure that is carried out to treat diseases of the entire vascular system. Intraoperative hemostasis, precise vision of intricate vascular anatomy, restenosis, implant-associated infection, and inadequate endothelium regeneration are among the enduring difficulties that continue to ... |
41953560 | Advancements and challenges of nanorobots in surgical medicine: design, applications, and interdisciplinary integration. | Surgical nanorobotics offers a strategy to surpass the physical constraints of conventional minimally invasive procedures. Designed to intervene at the cellular scale, these micro-agents facilitate high-precision tasks ranging from tumor margin delineation to targeted tissue manipulation. This article critically evalua... |
41953475 | Recent advances in low-temperature ceramic fuel cells: material design and applications. | Ceramic fuel cells (CFCs) are highly efficient and clean electrochemical energy conversion devices, featuring a wide range of available fuels (hydrogen, methane, ethanol and biomass gas) and the absence of the need for precious metal catalysts. They will play an important role in the future development of sustainable e... |
41953448 | Biohacking the human gut microbiome for precision health and therapeutic innovation. | Biohacking, the self-directed application of biotechnology, digital tools, and lifestyle interventions, has rapidly converged with gut microbiome science to create adaptive, individualized, and minimally invasive precision-health paradigms. This narrative review integrates current evidence on diet-based modulation, mic... |
41953199 | Exploring the therapeutic potential of <i>Tetrastigma bracteolatum</i> (Wall.) Planch. methanol extract and its different fractions: <i>in vitro, in vivo,</i> and <i>in silico</i> approaches. | <h4>Introduction</h4>Tetrastigma bracteolatum: (Wall.) Planch, an indigenous plant of Bangladesh, is traditionally used for pain management. This study aimed to determine its biological activities through an integrated <i>in-vitro</i>, <i>in-vivo</i>, and <i>in silico</i> approaches.<h4>Methods</h4>Crude methanol extra... |
41953034 | Plying potency assays for immunotherapy of solid tumors. | Potency assays for cellular immunotherapies have advanced considerably yet remain only partially aligned with the complex requirements of solid tumors, where trafficking, persistence, metabolic fitness and spatially constrained effector function are key determinants of <i>in vivo</i> performance. Critical quality attri... |
41953032 | Advancements and expanding applications of CAR-T cell therapy. | CAR T-cell therapy has become a transformative modality in oncology, demonstrating sustained clinical efficacy in hematologic malignancies. Recent investigations have expanded its potential beyond cancer to immune-mediated disorders, including autoimmune diseases such as multiple sclerosis and systemic lupus erythemato... |
41939137 | Fabrication and antibacterial properties of self-assembled lysozyme nanofilms induced by reduced glutathione. | This study developed a self-assembled lysozyme nanofilm at the air-water interface using reduced glutathione (GSH) as an inducer, demonstrating broad-spectrum antibacterial activity and tunable functionality. Through thiol-disulfide exchange, GSH reduces the disulfide bonds in lysozyme, leading to protein unfolding and... |
41937947 | <i>Gynostemma pentaphyllum</i>-derived extracellular vesicles alleviate skin aging by destabilizing STING. | Skin aging represents a multifaceted degenerative process that predisposes to dermatological pathologies, including infections, dermatitis, and malignancies, causing great physical and psychological distress to patients. Conventional therapies, including topical antioxidants and sunscreens, have shown limited efficacy ... |
41937948 | Reshaping psoriasis topical therapy: Continuous hydrogenation orchestrates 'redox-metabolic homeostasis' for efficient remission and relapse intervention. | Psoriasis represents a globally prevalent and chronic dermatological disorder, characterized by persistent hyperkeratosis, self-sustaining inflammatory cycles, and frequent relapse, posing substantial challenges for conventional therapies of compromised efficacy and biosafety. Here, we introduce a transformative strate... |
41930348 | Liquid-Liquid Phase Separation in Viral Infection and Immunology. | Liquid-liquid phase separation (LLPS) has emerged as a fundamental physicochemical principle that organizes macromolecules into dynamic, membraneless condensates. These assemblies are increasingly recognized as critical regulators of diverse cellular processes. Notably, both viruses and their hosts exploit LLPS to opti... |
41913906 | Gut-Brain Axis Dysregulation in Inflammatory Bowel Disease: Implications for Coagulation Abnormalities and Extraintestinal Manifestations. | Inflammatory bowel disease (IBD) involves chronic intestinal inflammation driven by gut-brain axis imbalance, fostering complications through an "inflammation-neuro-coagulation" triad. Current staging systems inadequately capture the dynamics of this multidimensional network. Therefore, integrated multi-omics analyses-... |
41908948 | Synthesis and Biological Evaluation of Imidazopyridine-Isatin Hybrids as Inhibitors of <i>Leishmania major</i> Growth. | <h4>Introduction</h4>More than 20 different species of Leishmania cause leishmaniasis, a multifaceted disease that ranges from mild cutaneous lesions to fatal visceral forms.<h4>Methods</h4>Sixteen novel hybrids were designed by covalently linking an imidazo[1,2-<i>a</i>]pyridine core to an isatin scaffold <i>via</i> a... |
41908596 | Research Progress on Antivirulence Agents Targeting the Accessory Gene Regulator (Agr) System of <i>Staphylococcus Aureus</i>. | With global spread of drug-resistant strains such as methicillin-resistant <i>Staphylococcus aureus</i>, conventional antimicrobial strategies face significant challenges, which prompt the development of antiinfective agents with alternative strategies. The antivirulence approach targets bacterial virulence factors wit... |
41907215 | Epigallocatechin Gallate Influences in Acute Respiratory Distress Syndrome by Regulating Gut Microbiota: Current Research Status and Therapeutic Prospects. | Acute respiratory distress syndrome (ARDS) is a life-threatening condition characterized by high mortality, with its pathogenesis involving multiple factors, including inflammatory responses, oxidative stress, and immune dysregulation. However, current clinical interventions remain limited. Recently, the "gut-lung axis... |
41903240 | Construction of novel magnetic amino-functionalized metal-organic framework/phenolic hydroxyl-functionalized covalent organic framework composite for highly efficient enrichment of trace bisphenols from aqueous samples. | An innovative porous magnetic solid-phase extraction composite material (Fe<sub>3</sub>O<sub>4</sub>@MIL-101(Cr)-NH<sub>2</sub>@Dha@Dha-TAPB), integrating amino-functionalized metal-organic frameworks and phenolic hydroxyl‑functionalized covalent organic frameworks, was constructed for the efficient extraction of bisph... |
41887591 | DeepSTFSynergy: A multi-scale structural information fusion method for personalized drug combination prediction. | Efficiently predicting drug synergy is crucial for developing personalized cancer combination therapy regimens. However, existing methods primarily focus on single-scale structural information and fail to explicitly model the interactions between multi-scale structural information from cell lines and drug pairs, limiti... |
41887485 | Synthesis of Cu-embedded carbon composites via in situ CNTs growth for efficient liquid iodine capture. | This study synthesized Cu@CNTs/C composite adsorbent materials through an in situ growth-carbonization strategy, integrating the structural robustness of carbon nanotubes (CNTs) with the high adsorption activity of metallic copper nanoparticles. The resulting material demonstrates excellent performance in the capture o... |
41887429 | Digestive performance differences between lotus seed starch-chlorogenic acid inclusion and non-inclusion complexes: Comparative analysis of static and dynamic high-pressure preparation systems. | The configuration of starch-polyphenol complexes plays a critical role in their digestive properties. In this study, inclusion and non-inclusion complexes of lotus seed starch and chlorogenic acid were prepared using static high pressure (SP: 100/500 MPa) and dynamic high pressure (DP: 10/50 MPa) techniques, respective... |
41887427 | Poly(tannic acid)-stabilized of Pickering emulsions to enhance multifunctional gelatin films for effective fruit preservation. | Despite the promise of gelatin films incorporated with bioactive essential oils for fruit preservation, the volatility, instability, and incompatibility of essential oils limit their practical applications. This study proposed a poly(tannic acid) (PTA)-mediated interfacial bridging strategy that enhanced the compatibil... |
41886835 | A supramolecular fluorescent probe targeting mitochondrial iron for assisting early Parkinson's disease diagnosis. | Early detection of Parkinson's disease (PD) before irreversible dopaminergic neuron loss remains a critical unmet need. Herein a novel supramolecular probe, DTPP@Q[7], was constructed via a host-guest assembly in which the fluorescent molecule DTPP is combined with the macrocycle cucurbit[7]uril (Q[7]) for real-time mo... |
41883856 | Metal complexes in medicine: structural scaffolds <i>vs.</i> functional centres. | Metal complexes occupy a distinctive position in medicinal chemistry by combining well-defined three-dimensional structures with tuneable reactivity that cannot be readily achieved using purely organic compounds. This review examines metal-based therapeutics through a unifying conceptual framework that distinguishes be... |
41877531 | An eco-friendly alkaline lignin/sodium alginate/β-cyclodextrin composite hydrogel for enhanced foliar deposition and sustained control of Botrytis cinerea with azoxystrobin. | <h4>Background</h4>Conventional pesticide formulations often suffer from limitations such as large particle sizes, poor adhesion, and susceptibility to environmental losses through volatilization and drift, leading to low utilization efficiency and potential ecological risks.<h4>Results</h4>To address these challenges,... |
41877521 | High-Throughput Microscale MOF Catalysis via Solid Dispersion Reactor Dosing. | Metal-organic frameworks (MOFs) exhibit exceptional structural diversity and tunable chemical environments, offering excellent opportunities for tuning the selectivity of catalytic centers confined to their pores. As such, MOF catalysts have been shown to exhibit distinct size-, regio-, and chemoselectivity relative to... |
41877432 | Anion-Directed Stacking Engineering in 2D Metal-Organic Frameworks Built From Silver(I) and Propeller-Chiral Tris(Triazole) Cage Ligands. | Precise control over interlayer stacking in two-dimensional (2D) materials is a powerful strategy for modulating functional properties. Yet how racemic assemblies of enantiopure layers influence the full spectrum of AA, AB, and ABC stacking patterns has remained unexplored. Here, we uncover this missing link with a fam... |
41877392 | Ratiometric Fluorescent Probe with Metal-Mediated Dual-Emission Centers for Ultrasensitive and Interference-Resistant SF<sub>6</sub> Monitoring in High-Voltage Equipment. | Developing SF<sub>6</sub> detection method with convenient, efficient, and interference-resistant is crucial for monitoring gas leaks in grid insulation systems. Here, we report a novel ratiometric fluorescent probe (NiCDs@MOF) with dual-emission centers, where carbon dots (NiCDs) are anchored within a Ni-based MOF via... |
41877192 | Microaerobic dark fermentation by purple bacteria as an emerging perspective for biohydrogen production-a review. | While in recent years, a lot of research regarding microbial dark fermentation for biohydrogen production has been carried out focusing on improving well-established processes, this review aims to draw attention to the discovery of a new method of process control, i.e., microaerobic dark fermentation in purple non-sulf... |
41876686 | Machine learning-guided design of energy-related catalysts from nanoparticles to single-atom sites. | Machine learning (ML) has been widely applied to accelerate the design and discovery of new molecules and materials. Recently, there has been growing interest in integrating ML into the design of heterogeneous catalysts, including nanoparticle catalysts (NC) and, in particular, single-atom catalysts (SACs). With the ra... |
41876639 | Glycosylation as a dynamic regulator of RLR and cGAS-STING innate immune signalling pathways. | Innate immune sensing by RIG-I-like receptors (RLRs) and the cGAS-STING pathway is tightly regulated by glycosylation. This review summarizes how distinct glycosylation modalities shape antiviral signaling at multiple levels. N-glycosylation in the ER-Golgi is essential for STING folding, stability, and signaling compe... |
41876510 | Linking photoelectron circular dichroism to the asymmetric total photoemission yield measured in aerosol nanoparticles of tyrosine. | Spectroscopic techniques that are sensitive to molecular chirality are important analytical tools to quantitatively determine enantiomeric excess and purity of chiral molecular samples. Many chiroptical processes however produce weak enantio-specific asymmetries due to their origin relying on weak magnetic dipole or el... |
41876501 | Post-synthetically modified crown ether-based supramolecular framework for efficient radium sequestration. | The proliferation of uranium tailings elevates environmental risks through <sup>226</sup>Ra (t<sub>1/2</sub> = 1600 years), a persistent uranium decay product exhibiting radiation/chemotoxicity threats and subsurface migration. Current <sup>226</sup>Ra<sup>2+</sup> sorbents, designed for low-activity (<100 Bq L<sup>-1<... |
41876392 | Electronically Coupled, Cofacially Linked, Hypervalent Antimony(V) Porphyrin Homodimer: Synthesis, Spectroscopy, and Photochemistry. | A covalently linked cofacial homodimer has been synthesized using hypervalent antimony(V) porphyrins. The two porphyrins are connected by an -OCH<sub>2</sub>O- bridge, maintaining a distance of 5.85 Å between the Sb centers. Despite the positive charge on the porphyrin entities, the resulting homodimer is structurally ... |
41875901 | Beyond the Sequence: Chemical and Topological Design and Innovations in mRNA Therapeutics. | Messenger RNA (mRNA) has rapidly emerged as a transformative therapeutic modality, exemplified by its growing applications in infectious diseases, oncology, and genetic disorders. The chemical programmability of mRNA allows researchers to modulate its function by introducing synthetic modifications across the molecule─... |
41875418 | Cryo-Structural Insights into Enzymatic Peptide Self-Assembly Driving Extrinsic Lytic Cell Death. | Programmed lytic cell death, including pyroptosis and necroptosis, involves intracellular enzymes that form membrane-rupturing pores. Tumor-associated ectoenzymes such as alkaline phosphatase (ALP), however, offer the potential to initiate lytic death extrinsically. Here, we design a phospho-biphenyl-capped peptide pre... |
41875368 | <i>In Cellulo</i> Fabrication of Supramolecular Protein Assemblies. | <i>In cellulo</i> protein assemblies, spanning protein cages, filaments, crystals, and biomolecular condensates, provide cells with modular strategies to package, organize, and regulate biomolecules and biochemical reactions. Their genetic encodability, structural diversity, and tunable material properties have also ma... |
41875363 | Physically Cross-Linked Biopolymer-Based Strong and Stretchable Organohydrogel with Self-Healing and Biocompatibility for Environmentally Tolerant Strain Sensors. | The development of wearable strain sensors increasingly focuses on multifunctional materials that integrate mechanical robustness, self-repairing capacity, temperature-resilient conductivity, and biocompatibility. Herein, we developed a physically cross-linked biopolymer-based organohydrogel by incorporating gelatin (G... |
41875350 | 2D Copper MOF Membranes with Precise Pores for Ionic Memory. | Biological ion channels play a critical role in the complex physiological processes of living organisms. Inspired by these natural systems, we demonstrate the fabrication of ultrathin 2D copper-based metal-organic framework (CuMOF) films and their application to mimic key functionalities of biological membranes. Using ... |
41875166 | Mechanism of 30S subunit recognition and modification by the conserved bacterial ribosomal RNA methyltransferase RsmI. | Ribosomal RNA (rRNA) modifications are important for ribosome function and can influence bacterial susceptibility to ribosome-targeting antibiotics. The universally conserved 16S rRNA nucleotide C1402, for example, is the only 2'-<i>O</i>-methylated nucleotide in the bacterial small (30S) ribosomal subunit and this mod... |
41875158 | Small molecule-constrained paratope mimetic bicyclic peptides as potent inhibitors of group 1 and 2 influenza A virus hemagglutinins. | Influenza continues to be a major threat to global health and a substantial economic burden. Innovative strategies are needed to tackle the growing resistance to established influenza therapeutics and to develop new therapeutics with novel mechanisms of action. Previous peptide and small molecule designs have been succ... |
41875154 | Fab-Fc and Fab-Fab interactions of variable strength and valency contribute to the high concentration viscosity of IgG<sub>1</sub> antibodies. | The variable domains in Fab regions are well-established contributors to high concentration viscosity of IgG, primarily through charge and hydrophobic interactions. In contrast, the roles of the Fc and the number of self-interacting sites (valency) are less well understood. Here, we investigate the relative contributio... |
41875121 | Ultrasound-triggered doxorubicin targeted delivery for liver cancer treatment: Reduced toxicity and improved efficacy. | Liver cancer, especially hepatocellular carcinoma (HCC), remains a major global health challenge, causing high mortality worldwide. Conventional chemotherapy often results in severe side effects due to its systemic distribution, which limits its effectiveness in targeting cancer cells specifically. The development of t... |
41875102 | Molecular insights into antimicrobial resistance and virulence in hospital-associated of vancomycin-resistant Enterococcus faecium isolates in a tertiary hospital in Bangkok Thailand. | Vancomycin-resistant Enterococci (VRE) are major pathogens causing nosocomial infections globally. This study investigated the genetic characteristics of vancomycin-resistant Enterococcus faecium (VREfm) in Thailand between June and November 2022. Fifty-two clinical VREfm isolates from Bangkok hospitals were analyzed f... |
41875078 | A quantitative cell-based reporter links TDP-43 aggregation and dysfunction to define pathogenic mechanisms. | TDP-43 pathology is a hallmark of fatal neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and limbic-predominant age-related TDP-43-encephalopathy (LATE). In affected patients, cytoplasmic TDP-43 aggregates are accompanied by disruption of its normal nuclear loca... |
41875055 | Yeast Display Technology Enables Rapid Discovery of Low-Nanomolar Macrocyclic Peptide Inhibitors of Human Angiotensin-Converting Enzyme 2. | Macrocyclic peptides (MPs) are valuable molecular formats for drug development, bridging small molecules and larger biologics due to their favorable pharmacological properties. Here, we describe the discovery of low-nanomolar inhibitors of human angiotensin-converting enzyme 2 (hACE2) by quantitatively screening millio... |
41875044 | Spin State in Au Porphyrins Modulated by Charge Transfer on Au(111). | Controlling spin states at the single-molecule level is a crucial step toward functional molecular spintronic devices. Au porphyrins, as efficient electron acceptors, are highly sensitive to charge transfer on surfaces and offer a promising route to investigate spin-state modulation in single-molecule magnets. Here, we... |
41874885 | Advancements in nanobiosensors for early cancer detection, challenges, treatment, and future prospects: a comprehensive review. | <h4>Background</h4>Cancer is one of the leading causes of global mortality. To reduce treatment costs, improve quality of life and increase survival outcomes for an individual, early detection of cancer is crucial. Advances in nanobiosensors offer point-of-care detection with high specificity and sensitivity for biomar... |
41874862 | Digitally enhanced fracture liaison service in Austria-a feasibility analysis. | Fragility fractures often signal untreated osteoporosis. This study shows that a digitally enhanced Fracture Liaison Service (FLS) can identify affected patients in routine hospital care and improve structured assessment and treatment. Dedicated staff remain essential to translate digital solutions into effective fract... |
41874806 | Self-powered finger motion sensing for piano training based on the ionic hydrogel triboelectric nanogenerator. | Wearable sensing technologies have attracted increasing attention for real-time monitoring of human motion and physiological activities. In this study, a PTPAVI-Al<sup>3+</sup> ionic conductive hydrogel-enabled triboelectric nanogenerator (PA-TENG) is designed as a multifunctional platform capable of converting mechani... |
41874791 | At the core of global bioenergy: polyamines and transglutaminases in chloroplasts. | Chloroplasts are the energy factories of photosynthetic life. The energy and the plant biomass of the planet depend on the activity of chloroplasts. Their efficiency results from a delicate balance between membrane organization, metabolic regulation and the maintenance of protein homeostasis. Among the molecular factor... |
41874749 | Colorimetric detection of amino acids enabled by functional nanomaterials: mechanisms, performance evaluation, and translational perspectives. | Amino acids, as the fundamental building blocks of proteins and vital participants in biological activities, play a key role in biomedical, food science, and clinical diagnostics, where rapid and sensitive detection is of great importance. The colorimetric method is widely favored due to its simplicity, low cost, and a... |
41874661 | Interleukin-6 to identify mildly injured patients in the trauma resuscitation room - a clinical feasibility study. | <h4>Purpose</h4>Overtriage in the trauma resuscitation room (TRR) is often a consequence of admission based solely on trauma mechanism criteria. As interleukin-6 (IL-6) can assess injury severity in critically injured patients, the hypothesis of this study was that IL-6 can differentiate upon admission between mild (In... |
41874660 | Advanced Bayesian BMD-Derived Genome-Wide Polygenic Scores Enhance Clinical FRAX-Based Fracture Risk Prediction in Postmenopausal Women. | Current fracture prediction tools, including the Fracture Risk Assessment Tool (FRAX), rely primarily on clinical risk factors and bone mineral density measurements, yet omit genetic information. Given osteoporosis's substantial heritability (estimated at 50-80%), excluding genetic data may lead to clinical misclassifi... |
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