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41837709 | Determination of vidarabine using fluorescein sodium probe-based resonance Rayleigh scattering. | The establishment of novel methods for drug content determination provides additional options for pharmaceutical quality control. A new method for detecting vidarabine (Ara-A) has been developed, utilizing the acidic anionic dye Fluorescein Sodium (FLS) as a resonance Rayleigh scattering (RRS) probe. Within a Clark-Lub... |
41810977 | Opposite enantioselectivities displayed by supramolecular helical catalysts with non-enantiomeric "sergeants". | Triarylamine trisamide (TATA) coassemblies composed of one achiral phosphine-based monomer and one chiral monomer, as the "soldier" and "sergeant" respectively, were found to adopt opposite handednesses and favour enantiomers of a catalytic product with "sergeants" bearing (<i>S</i>) stereogenic centres placed either i... |
41810599 | Fast-track discovery of MOF-derived M@NC catalysts for HMF-to-FDCA oxidation <i>via</i> DFT prescreening and Box-Behnken optimization. | Efficient HMF-to-FDCA oxidation requires the co-optimization of intrinsic active-site chemistry and a multidimensional reaction window. Here we report a fast-track DFT-to-experiment workflow that accelerates both catalyst selection and condition optimization, delivering a 94.3% FDCA yield after Box-Behnken optimization... |
41808546 | Preparation of covalent organic frameworks coated with cell membranes for precise analysis of cancer exosomes. | In this study, we have developed an electrochemical biosensor based on cell membrane-coated covalent organic frameworks for the selective detection of homologous exosomes. The biosensor can achieve a detection limit as low as 27 particles per µL. Moreover, it can effectively differentiate serum samples from patients wi... |
41805819 | Unveiling a host-guest assembly composed of an emissive Ir(III) complex salt and a concave aromatic host at a local minimum state. | A host-guest complex formed at a local minimum state was isolated and characterized. Owing to solubility modulation induced by the formation of a supramolecular assembly, the host-guest complex at a local minimum state selectively precipitated. The photophysical properties of the guest gave structural information about... |
41777173 | Conductive metal-organic frameworks: emerging strategies for high-performance energy storage. | Conductive metal-organic frameworks (c-MOFs) have emerged as a distinctive class of crystalline, electronically active materials that bridge molecular design with electrochemical energy-storage functionality. Their significance is underscored by the recent Nobel Prize in Chemistry recognizing pioneering advances in MOF... |
41738793 | Laser writing of plasmonic catalytic microchannels on UiO-66 layer. | Plasmon-assisted catalysis offers an attractive route for solar-to-chemical energy conversion, yet its practical integration into scalable flow systems remains limited by complex fabrication steps and poor nanoparticle stability. Here, we report a one-step laser-assisted method for simultaneously forming gold nanoparti... |
41725604 | Reshaping the oxidative stress microenvironment by bionic chiral Cu-Phe (D/L) nanozymes for promoting osteoimmunomodulation and osteogenic differentiation. | Inflammatory bone defects pose a serious threat to human health and traditional stem cell therapies exhibit limited efficacy in addressing the high oxidative stress environment associated with such defects. Inspired by the response mechanism of the intracellular antioxidant defense system (IADS), we propose a metal-org... |
41725531 | Selective binding of sulphated glycosaminoglycans induces self-assembly of naphthalene diimide into fluorescent nanofibers. | The self-assembly of π-conjugated chromophores directed by biomolecular recognition offers a smart strategy to create bio-synthetic hybrid nanomaterials with emergent properties. Here, we report a novel amphiphilic, cationic naphthalene diimide (NDI) derivative that undergoes supramolecular polymerization upon interact... |
42006307 | Comparative analysis of clearing methods for 3D imaging of the vasculature in mineralized mouse tissues. | Historically, visualization of vascular networks within the musculoskeletal system, particularly in mineralized tissues such as bones and joints, has been limited to conventional 2D histological approaches. Recent advances in optical tissue clearing technologies and fluorescence imaging approaches in whole, intact tiss... |
42003885 | Unlocking the potential of mRNA nanomedicines for comprehensive fibrosis therapy. | Fibrosis is a common pathological endpoint of numerous chronic diseases and a major driver of progressive organ dysfunction and failure. It is characterized by persistent fibroblast activation, excessive extracellular matrix deposition, and irreversible disruption of tissue architecture. Despite substantial clinical de... |
41993635 | Photothermal-driven multifunctional injectable hydrogel platform for promoting diabetic bone defect repair through synergistic immunomodulation and bone homeostasis. | <h4>Background</h4>Excessive inflammation and exacerbated oxidative stress are significant hallmarks of the diabetic bone microenvironment, which give rise to dysregulated immune reactions and impaired bone homeostasis, thereby hindering bone defect healing and increasing the incidence of bone nonunion.<h4>Methods</h4>... |
41993634 | Advancements in nanomedicine for the therapeutic regulation of efferocytosis: opportunities and challenges. | Efferocytosis is a conserved event that plays an essential role in maintaining tissue homeostasis and immune balance. However, dysregulation of efferocytosis can induce disturbed apoptotic cells clearance and immune disorders, fueling an array of diseases, such as inflammatory diseases, autoimmunity, and cancers. The p... |
41983115 | Cascade Biorefinery of <i>Chlorella vulgaris</i>: Optimized Extraction Sequencing for Sustainable Whole-Biomass Valorization. | An integrated biorefinery model was developed and experimentally validated for the multiproduct valorization of <i>Chlorella vulgaris</i> biomass through the sequential and polarity-driven extraction of high-value bioactive fractions. The extraction of <i>C. vulgaris</i> biomass was based on integration of mechanical d... |
41982728 | Synthesis and LCMS Characterization of a 1275-Member Library of 24-Atom Triazine Macrocycles Derived from Quantitative Dimerization Occurring with >99.9% Fidelity. | Efficient routes to libraries of nonpeptidic macrocycles facilitate drug discovery. Monomers presenting hydrazine and acetal groups separated by a triazine ring and glycine linker dimerize efficiently to yield homodimers (when one monomer is employed) or a mixture of two homodimers and a heterodimer (when two monomers ... |
41978095 | Structural Characterization and Anti-Colitis Mechanisms of <i>Polygonatum sibiricum</i> Polysaccharides via Modulation of Neutrophil Extracellular Traps (NETs)-Macrophage Crosstalk. | <h4>Background</h4><i>Polygonatum sibiricum</i> (PS), a perennial herbaceous plant belonging to the Liliaceae family, is widely distributed in China and other East Asian countries. PS has been used as food and medicine for thousands of years, and its rhizomes are rich in <i>Polygonatum sibiricum</i> polysaccharides (PS... |
41977543 | Fast Dissolving Resveratrol-Polyvinylpyrrolidone Nanofibrous Films Fabricated in Bulk Using a Special Hole Electrospinning Technique. | Batch production of nanomaterials is highly desired for developing commercial nanoproducts. Here, a brand-new electrospinning method, termed hole electrospinning, was developed for batch production of drug-loaded polymeric nanofibers. Using resveratrol and polyvinylpyrrolidone as model drug and filament-forming matrix,... |
41977176 | Application and Potential of Local Drug Delivery Systems for Antibacterial Treatment of Periodontitis. | Periodontitis (PD) is a chronic inflammatory disease characterized by the progressive destruction of periodontal supporting tissues. As one of the most prevalent chronic diseases, PD affects more than 743 million people globally, some with serious systemic health implications. Plaque accumulation constitutes the key dr... |
41977177 | Roles of Subunit ND2/NuoN in the Proton Pumping Coupling Mechanism of Complex I. | Complex I (NADH:quinone oxidoreductase, CI) is central to cellular aerobic energy metabolism. The L-shaped structure of CI is unique, where the hydrophilic arm is responsible for the electron transfer function and the membrane arm operates proton pumping. These two functional sites are spatially far apart yet functiona... |
41977166 | Elucidating the Multi-Enzymatic Mechanism of Bacterial Decolorization of Azo and Indigoid Dyes: An Integrated Study of Degradation Pathways and Molecular Docking. | Synthetic dyes discharged from the textile and dyeing industry present a significant environmental and health hazard due to their inherent toxicity, environmental persistence, and potential carcinogenicity. Microbial degradation has garnered significant interest as a cost-effective and eco-friendly strategy for dye was... |
41977174 | QSAR-Guided and Fragment-Based Drug Design of Monoterpenoid Inhibitors Targeting Ebola Virus Glycoprotein. | Ebola virus disease remains one of the most serious viral infections with no approved small-molecule treatments. The Ebola virus glycoprotein (EBOV-GP), which enables the virus's entry to host cells, is a promising target for drug discovery. In this study, a multistage computer-aided drug discovery approach was used to... |
41977170 | Genome-Wide Identification of WRKY Gene Family in Artemisia and Its Expression Analysis of Aphid Resistance. | WRKY is a crucial transcription factor involved in plant growth, development, and responses to abiotic stress. In the present study, a total of 182 <i>AaWRKY</i> transcription factor members were identified across the <i>Artemisia argyi</i> genome and found to be distributed across 17 chromosomes. Evolutionary analysis... |
41977161 | Ochratoxin A and Clear Cell Renal Cell Carcinoma: Exploring Potential Molecular Links Through Network Toxicology and Machine Learning. | Ochratoxin A (OTA), a prevalent food contaminant, is closely linked to the development of various cancers, including clear cell renal cell carcinoma (ccRCC). However, the potential mechanisms remain to be explored. In this study, we employed network toxicology, machine learning, and molecular docking techniques to syst... |
41976583 | Nature Meets Science: The Role of Food-Grade Oils and Green Excipients in Pharmaceutical Nanoemulsion Formulation. | Nanoemulsions are pivotal carriers which are increasingly adopted as carriers for poorly soluble active molecules. This review provides a critical overview of 'green' nanoemulsions, which are systems based on renewable, biodegradable, and non-toxic components and/or using sustainable production techniques. We here focu... |
41976285 | Metastatic Odyssey: Decoding the Genomic Journey from Primary Colorectal Cancer to Disseminated Disease. | Metastatic colorectal cancer (mCRC) accounts for 90% of CRC-related mortality. This review synthesizes insights from comparative genomics tracing evolutionary trajectories from primary tumor to disseminated disease. Multi-region sequencing reveals metastatic seeding often occurs early-before clinical detection-challeng... |
41976121 | Essential Oils Applied to Textile Substrates with Emphasis on Antibacterial Properties: Review Article. | Essential oils (EOs) are well-known in traditional medicine, pharmacy, the food industry, and cosmetics because they are readily available and have proven efficacy across a wide range of applications. They are natural, bio-based, and biodegradable, and when applied accurately, they exhibit effective action against micr... |
41976120 | Functionalized Fullerene Nanomaterials: Evaluating Heteroatom Identity for Enhanced Charge-Transfer and Reactivity. | This study explored the electronic and structural tunability of fullerene (C<sub>60</sub>) derivatives via functionalization with heteroatoms (O, S, Se) in mono-, di-, and tri-bridged configurations, including covalently modeled dimers. Calculations were performed using density functional theory (DFT) at the B3LYP/6-31... |
41976124 | Defect Engineering in Zr (IV)- and Ti (IV)-Based Metal-Organic Frameworks to Enhance Photocatalytic Properties. | Metal-organic frameworks (MOFs) are unique microporous materials being explored for a wide range of applications. Their porosity and high surface areas can readily be exploited for guest-host interactions, separations, and photochemical catalysis, but many suffer from poor charge separation and fast electron-hole recom... |
41975699 | Advances and Opportunities in NIR-II Endoscopy: From Diagnosis to Therapeutic Applications. | Endoscopy refers to the minimally invasive optical visualization and examination of internal structures within the body. Its significance lies in diagnosing intraluminal tissue abnormalities and assisting therapeutics, especially in the gastrointestinal tract. However, conventional optical endoscopes are limited by the... |
41972669 | Bridging Regenerative and Restorative Stem Cell Therapies in Parkinson's Disease. | The prevalence of Parkinson's disease (PD) is projected to rise, stressing the urgency for disease-modifying therapies. Its complex pathophysiology, characterized by α-synuclein aggregation, mitochondrial dysfunction, oxidative stress, and chronic neuroinflammation, continues to complicate therapeutic development. Moun... |
41972668 | Modulation of miRNA Signature in Human Adipose Tissue After 3 Months of ω-3PUFA Supplementation. | Obesity is a persistent public health issue, often resulting in metabolic complications such as insulin resistance (IR). The secretion of pro-inflammatory cytokines from adipose tissue (AT) is increased during obesity, contributing to the impairment of systemic insulin sensitivity. While interventions in animal models ... |
41972614 | Ordered Macro-Microporous ZIF-8 Decorated with Nanoparticles for Highly Sensitive Detection of Auramine O in Tropical Fruits. | Herein, an electrochemical sensor is reported for the first time based on an ordered macro-microporous composite derived from metal-organic frameworks (MOFs) for the highly sensitive detection of auramine O (AO), a Group 2B carcinogen. The hierarchical pore architecture, integrating an ordered macroporous network with ... |
41972528 | A Comprehensive Assessment Using Physicochemical and Microbial Indicators Reveals Enhanced Soil Health Under Integrated Rice-Red Swamp Crayfish (<i>Procambarus clarkii</i>) Farming. | Soil degradation poses a serious threat to the sustainability of global agricultural development, endangering the foundation and environment of human survival. Therefore, elucidating the effects of different agricultural production patterns on the quality and health of paddy soils is of great significance. To investiga... |
41972526 | Exploring the Prognostic, Mutational and Therapeutic Potential of ANXA2 in Ovarian Cancer via Multi-Omics and In Silico Approach. | <h4>Background</h4>Among gynecological malignancies, ovarian cancer (OC) remains a leading cause of mortality worldwide, often characterized by the highest fatality-to-case ratio due to its asymptomatic progression and late-stage detection. Despite substantial investigation, the root cause of disease development and pa... |
41972192 | Safety evaluation of an effervescent curcuminoids-ascorbic acid-polysaccharide-β-cyclodextrin (CUR-A-Poly-β-CD) inclusion complex powder in healthy volunteers: A non-placebo-controlled pilot study. | Colorectal cancer (CRC) is a prevalent and aggressive malignancy with a high mortality rate. Although chemotherapy can improve survival outcomes, it is frequently associated with undesirable side effects. Curcuminoids, the principal polyphenol derived from <i>Curcuma longa</i> L., have demonstrated promising potential ... |
41971234 | Stretchable cyclodextrin slide-ring copolymer self-generating hydrogels for high-performance flexible electronics. | Supramolecular flexible electronic devices have received much attention due to their wide applications in the fields of chemistry, physics, materials and biology. Herein, we reported a slide-ring supramolecular hydrogel prepared by a thermal-initiated polymerization of acrylamide (AM), acrylic acid (AA), poly(3,4-ethyl... |
41970929 | Stimuli-Responsive MOF Nanocarriers for Precision Pulmonary Delivery of Aloperine in Acute Lung Injury. | Acute lung injury (ALI), known as a severe respiratory disease, often leads to increased inflammation, harm to the alveolar-capillary barrier, and decreased oxygenation, with high morbidity and mortality rates. Herein, we study aloperine (ALO), a hydrophobic anti-inflammatory alkaloid with traditional Chinese medicine ... |
41970916 | Thermal Behavior of 2,2,3,3,5,5,6,6,8,8,9,9,11,11,12,12-Hexadecamethyl-2,3,5,6,8,9,11,12-octasila-1,4,7,10(2,5)-tetrathiophenacyclododecaphane in the Crystalline State. | Disilanylene-bonded thiophenophanes constitute a new class of σ-π-conjugated macrocycles with potential for unique solid-state behaviors. Herein, we report the synthesis of 2,2,3,3,5,5,6,6,8,8,9,9,11,11,12,12-hexadecamethyl-2,3,5,6,8,9,11,12-octasila-1,4,7,10-(2,5)-tetrathiophenacyclododecaphane, <i><b>c</b></i> <b>-Th... |
41970888 | Molecular Mimicry Inference, Therapeutic Target Identification, and Natural Product Inhibition Study in <i>Cardiobacterium valvarum</i> through Bioinformatics Approach. | <i>Cardiobacterium valvarum</i> is a known cause of infective endocarditis (IE). Autoimmune responses have been implicated in contributing to the inflammatory processes observed in IE. Molecular mimicry significantly influences the interaction between pathogens and host immune systems, frequently resulting in autoimmun... |
41970872 | Cytotoxicity and DNA Damage Ability of Isomeric <i>meso</i>-Tetra(cisplatin)porphyrins in Keratinocytes and Melanoma Cells Treated with Photodynamic Therapy. | In this study, we evaluated and compared the cytotoxicity and DNA damage-inducing effects of two porphyrins conjugated with cisplatin at two different positions on the pyrrolic rings (<b>3-cis-PtTPyP</b> and <b>4-cis-PtTPyP</b>) with free cisplatin after exposure to white light. Both porphyrin molecules induced DNA dam... |
41970853 | Boosting Hydrogen Evolution Kinetics with MoS<sub>2</sub>-Decorated TiO<sub>2</sub> Nanotubes. | The development of efficient and durable nonplatinum-based electrocatalysts for the hydrogen evolution reaction (HER) remains a key challenge. This study explores the heterojunction between titanium dioxide nanotubes (TiO<sub>2</sub> NTs) and molybdenum disulfide quantum dots (MoS<sub>2</sub> QDs) as a viable alternati... |
41970504 | Hyaluronic acid microneedle patch for transdermal delivery of naringin-loaded PEGylated terpesomes in a rat model of rheumatoid arthritis: Modulation TGF-β1, oxidative stress, and inflammation. | Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease that causes progressive joint damage and systemic effects. Naringin (NRG), a citrus-derived flavonoid with potent anti-inflammatory and antioxidant activities, is hindered by poor solubility and low bioavailability in clinical applications. NRG was ... |
41960432 | (-)-Epicatechin and inflammation: Unraveling the role of microbial metabolites and interindividual metabolic variability. | (-)-Epicatechin (EC), a dietary flavan-3-ol abundant in tea, cocoa, and certain fruits, has demonstrated promising anti-inflammatory activity. This review summarizes the chemical structure, absorption, distribution, metabolism, and excretion (ADME) characteristics, and molecular mechanisms through which EC modulates in... |
41960188 | Acetylation modification in malignant progression and therapeutic resistance of gliomas. | Gliomas are the most common and aggressive primary malignant tumors of the central nervous system, characterized by diffuse infiltration, rapid proliferation and dismal prognosis. Despite advances in multimodal treatments, including surgical resection, radiotherapy and targeted therapies, clinical outcomes remain unsat... |
41958967 | Antimicrobial peptides: emerging next-generation strategy for sustainable plant disease management. | Plant diseases reduce agricultural productivity worldwide, and this decline is further accelerated by climate variability, monoculture cultivation systems, and the excessive use of synthetic agrochemicals. Overuse of chemical (synthetic) pesticides in agriculture results in ecological stress, including loss of benefici... |
41958938 | Exploring the therapeutic potential of naturally occurring taxifolin, a dietary flavonoid: an updated comprehensive review. | <h4>Purpose</h4>Flavonoids, well-known as key bioactive compounds in numerous medicinal plants, help protect these plants against both biotic and abiotic stresses and are linked to the prevention of various degenerative diseases. The diverse pharmacological effects and therapeutic potential of flavonoids are influenced... |
41958937 | Mannosylated nanocarriers: a precision targeting strategy for tumors and infectious diseases. | Conventional chemotherapy often suffers from systemic toxicity, suboptimal efficacy, and drug resistance due to the non-specific distribution of drugs in the treatment of tumors and infectious diseases. Mannose-functionalized nanodelivery systems present a promising precision-targeting strategy to overcome these challe... |
41958930 | From microfluidics to nanodelivery: artificial intelligence reshapes neuropharmacology research strategies. | Neurological diseases are characterized by complex etiology, heterogeneity, and significant differences in therapeutic responses, which severely constrain the efficiency of new drug development and the success rate of clinical translation. In recent years, micro- and nanotechnology (micro/nanotechnology) technologies h... |
41958834 | Integrating diagnosis and therapy in hepatocellular carcinoma: advances in nanotheranostics. | Hepatocellular carcinoma (HCC) poses significant challenges in early diagnosis and effective treatment, leading to a poor prognosis. The emerging strategy of "theranostics," which integrates diagnostic and therapeutic functions into a single platform, offers a promising solution to overcome these limitations. This revi... |
41958661 | Microbe-driven immune suppression in colorectal cancer: the <i>Fusobacterium nucleatum</i> playbook. | Fusobacterium nucleatum, a key oral-pathobiont in colorectal cancer (CRC), has evolved from a presumed "passenger" to an active "co-conspirator" in tumorigenesis. This review systematically delineates its core role as an "architect of the immune microenvironment," whereby it remodels T-cell immune responses through pre... |
41958655 | Telodendrimer nanotrap for selective cytokine removal from sepsis patient plasma. | <h4>Introduction</h4>Sepsis remains difficult to treat, resulting in persistently high mortality, creating a significant clinical need for novel therapeutic approaches that provide precise immune modulation. A highly customizable telodendrimer nanotrap (TDNT) platform was developed to selectively remove inflammatory cy... |
41958651 | Targeting IL-12 for pancreatic cancer immunotherapy: advances in delivery strategies and clinical translation. | Pancreatic ductal adenocarcinoma (PDAC) remains highly resistant to conventional immunotherapies due to its immunosuppressive tumor microenvironment. Interleukin-12 (IL-12), a potent immunostimulatory cytokine, has demonstrated remarkable therapeutic potential across a range of malignancies. However, systemic administr... |
41958649 | P62 in colorectal cancer: from inflammation suppression to cancer promotion. | The autophagy adaptor and scaffold protein p62 plays a critical role in colorectal cancer (CRC) progression. As a malignancy driven by chronic inflammation, CRC arises from the combined effects of oncogenic signaling activation, genetic mutations, and epithelial barrier disruption. During early stages of inflammation, ... |
41958637 | Lanthanide-containing visible-light-excited thermosensitive luminescent films. | Among the methods of temperature measurement, luminescent thermometry has recently become increasingly interesting due to a number of advantages over traditional thermometers such as high sensitivity and spatial resolution, no need for contact with the analyzed object, and the capability for remote monitoring of temper... |
41953053 | 3D bioprinting of tissues and organs for systemic diseases and localized injuries. | Three-dimensional (3D) bioprinting integrates engineering, materials science, and biology to fabricate living tissues with precise spatial control. By enabling the layer-by-layer deposition of cells and biomaterials, it overcomes many limitations of traditional scaffold-based tissue engineering and offers new opportuni... |
41948434 | Comprehensive Lithium Polysulfide Diffusion Insights within Solid-State Electrolytes. | Lithium-sulfur (Li-S) batteries are highly attractive for next-generation energy storage applications due to their low cost, high theoretical energy density, and environmental benefits (nontoxicity, reducing reliance on rare metals, etc.). However, the implementation of Li-S batteries in the current battery manufacturi... |
41935486 | Ultrafast Micro solid-phase extraction of cobalt using a novel magnetic europium-metal organic framework nanocomposite from fruits, vegetables, and different water samples. | Trace cobalt contamination in food and water poses environmental and health concerns. This paper presents a novel magnetic europium-metal organic framework (Eu-MOF) nanocomposite for rapid magnetic micro-solid-phase extraction of Co(II) prior to flame atomic absorption spectrometric analysis. The adsorbent was synthesi... |
41930290 | Resonator-based add-drop filters enabled by flexible polymorphic crystals with TADF-RTP motifs. | We demonstrate the use of yellow and green fluorescence (Y-FL and G-FL) obtained from polymorphic crystals as signals in an add-drop filter (P-ADF). This innovation leverages two distinct crystalline polymorphs, green (G) and yellow (Y), of 5'-(9-ethyl-9<i>H</i>-carbazol-3-yl)-[2,2'-bithiophene]-5-carbaldehyde (CZ-CHO)... |
41928908 | Mutagenesis-based evolution enables rapid retargeting of l-aptamers for structured RNA recognition. | Mirror-image l-(deoxy)ribose nucleic acid aptamers (l-aptamers) enable high-affinity, selective recognition of native structured RNAs <i>via</i> shape-based, cross-chiral interactions rather than Watson-Crick base pairing. However, achieving this level of specificity has typically required <i>de novo</i> selection from... |
41918967 | Research Progress on the Mechanism and Targeted Intervention of G Protein-Coupled Bile Acid Receptor 1 (GPBAR1)-Mediated "Inflammation-Apoptosis-Metabolism-Microcirculation" Regulatory Network in Hepatitis B-Associated Liver Failure. | Hepatitis B-associated liver failure (HBV-LF) is a severe hepatic disease induced by hepatitis B virus infection, characterized by massive hepatocyte necrosis, rapid liver dysfunction, uncontrolled inflammation, bile acid metabolism disorders and immune microenvironment imbalance. It has a high short-term mortality of ... |
41918847 | Nano-Modified Titanium Implant Surfaces for the Prevention and Treatment of Peri-Implantitis: A Review. | Peri-implantitis is a primary cause of long-term implant failure, and its pathogenesis is closely associated with the formation of bacterial biofilms on implant surfaces. Conventional therapies, such as mechanical debridement and local/systemic antibiotic administration, have limitations in achieving sustained antibact... |
41918848 | Simvastatin and Moxifloxacin Co-Delivery via ZIF-8/PDA Coating on PEEK Implants: A Strategy for Combating Implant-Associated Infection and Enhancing Osseointegration. | <h4>Background</h4>Polyetheretherketone (PEEK) is a promising orthopedic implant material due to its bone-matched elastic modulus and radiolucency. However, its clinical application is limited by biological inertness and lack of antibacterial activity, which predispose to implant-associated infection (IAI) and poor oss... |
41918613 | Porous organic polymers based on carbon-carbon coupling reaction: synthesis and applications. | Porous organic polymers (POPs) are a class of materials formed by covalent bonding, which possess large specific surface area, good physical and chemical stability, and strong designability. Among these, POPs constructed through carbon-carbon coupling, including conjugated microporous polymers (CMPs), porous aromatic f... |
41916035 | Meroterpenoids from Rhododendron dauricum and the self-assembly driven antibacterial enhancement of grifolin. | Infections caused by pathogenic bacteria, particularly Staphylococcus aureus and Escherichia coli, present severe challenges to public health due to their virulence and persistence. The search for novel antimicrobial scaffolds from natural sources is a critical strategy to combat these threats. Rhododendron dauricum, a... |
41913747 | Multifunctional Graphene Oxide Quantum Dot Nanoformulation with Key Immunomodulation for Effective Anticancer Therapy in Mice Model. | <h4>Introduction</h4>To overcome limitations in melanoma therapy by developing a targeted nanoplatform based on reduced graphene oxide quantum dot (rGOQD) that integrates photothermal therapy (PTT), chemodynamic therapy (CDT), and immune modulation.<h4>Methods</h4>The multifunctional rGOQD/MnO<sub>2</sub>/CpG/Q/FA syst... |
41913737 | Nanoparticle-Mediated PPAR Modulation of Macrophage Polarization in Radiation Enteritis: A Narrative Review. | Radiation enteritis (RE) is a frequent and clinically important adverse effect of abdominal radiotherapy, characterized by acute inflammatory injury and longer-term fibrotic remodeling of the intestinal tract. Most patients receiving pelvic or abdominal irradiation experience measurable worsening of intestinal function... |
41911660 | A theoretical study of supramolecular chemotherapy with CB[7] and CP[6]: Electrostatic-driven displacement of platinum-based drug. | Supramolecular host-guest systems have gained relevance as platforms for controlled drug release. In this study, we conducted a theoretical comparison between two macrocyclic hosts, cucurbit [7]uril (CB [7]) and carboxylated pillar [6]arene (CP [6]), used as potential drug carriers for platinum-based anticancer agents,... |
41905210 | PVP-mediated Zr-melamine-MOF/PVDF membranes for efficient uremic toxin removal and anti-fouling. | Conventional hemodialysis membranes suffer from limited toxin adsorption capacity and poor biocompatibility. This study proposes a novel strategy to fabricate high-performance composite membranes by incorporating polyvinylpyrrolidone (PVP)-modified Zr-melamine metal-organic frameworks (MOFs) into a polyvinylidene fluor... |
41895457 | Binding of the elastin peptide VGVAPG and lactose to the human elastin binding protein. | Elastin-derived peptides (EDPs) interact with elastin-binding protein (EBP), a key component of the elastin receptor complex, modulating cellular processes such as protease activation, apoptosis, and chemotaxis via regulation of NEU-1 sialidase activity. Despite their therapeutic relevance, the structural basis of EDP-... |
41890561 | Lan enzyme-free construction of lanthionine-bridged macrocyclic phage libraries. | Phage display is a powerful technology for discovering macrocyclic peptide ligands. Many phage display-revealed peptide inhibitors comprise disulfide crosslinks, which unfortunately exhibit vulnerability to reduction and proteolysis. Lanthipeptides are a family of ribosomally synthesized peptides that harbor thioether ... |
41889558 | Lanthanide ion-doped carbon dots (Ln-CDs) as fluorescent nanoprobes: a review. | Breakthroughs in nanoscale science and engineering have facilitated the design of nanomaterials with exceptional optical behaviors. Over the past decade, numerous fluorescent nanoprobes have been reported for the highly sensitive and selective detection of a wide range of analytes. Among these, doped carbon dots (CDs) ... |
41889547 | Dual-ligand surface engineering of Ni-based nanostructures for efficient urea electrooxidation <i>via</i> Ni<sup>3+</sup> activation and charge-transfer modulation. | Nickel-based metallic nanomaterials represent highly promising electrocatalysts for the urea oxidation reaction (UOR), enabling the simultaneous benefits of efficient hydrogen production and wastewater treatment. However, their catalytic performance is constrained by slow interfacial charge transfer and insufficient ex... |
41889542 | Effect of π-spacer moieties coupled to a porphyrin/PC70BM donor-acceptor for promising organic photovoltaic properties: a DFT study. | The present study involved the design of porphyrin-based molecules (FF1-FF4) with a D1-π-D2-π-D1 configuration. This was accomplished by adding distinct π-spacers to a reference donor molecule. This research employs DFT and time-dependent DFT analyses at the CAM-B3LYP/6-31G(d,p) level to explore optoelectronic and phot... |
41889541 | Mg-Fe layered double hydroxides as multifunctional materials for manganese removal and methanol electrooxidation. | This study evaluated how well Mg-Fe layered double hydroxides (LDH) removed manganese (Mn<sup>2+</sup>) from aqueous media and electrocatalytic methanol oxidation. The structural and physicochemical properties of the materials both prior to and after the adsorption process were characterized by X-ray diffraction, infra... |
41889539 | Effect of bleaching process on the allomorph, crystalline index, morphology, and thermal stability of cellulose nanocrystals derived from rice straw. | Rice straw (RS), a renewable byproduct of rice production, represents a promising source of cellulose nanocrystals (CNC). Bleaching is essential for obtaining high-purity cellulose and reducing RS recalcitrance by removing hemicellulose and lignin. This study compares two bleaching methods-alkaline hydrogen peroxide (A... |
41884332 | Advances in Biomaterials Development and Their Energy Harvesting Application. | Biomolecular self-assembly presents a convenient and promising approach for fabricating functional nanomaterials. The inherent structural and functional diversity of biomolecules facilitates the creation of a wide spectrum of biological nanomaterials through this intricate process. These versatile materials have demons... |
41882973 | Adaptive Corner-Pocket Channels in a Metal-Organic Framework for Acetylene Ultra-Fast Diffusion and Storage. | Ultra-microporous molecular sieving materials offer exceptional size- and shape-selective gas separation, yet their practical use is often limited by slow diffusion kinetics and low adsorption capacities. Here, we report a low-cost manganese-based metal-organic framework (MOF), Mn-dcbp, featuring an adaptive "corner-po... |
41882943 | Temporally Controlled Interconversion Between Suprasome and Supracube Structures to Regulate Catalytic Activities. | Compartmentalized structures act as catalytic hubs, facilitating prebiotic chemical transformations without enzymes. However, emulating their dynamic behavior and catalytic activity with temporal precision in artificial systems poses a formidable challenge. This study presents the development of supramolecular compartm... |
41882933 | Ultra-High-Brightness Ln-MOFs X-ray Scintillators by Heavy Atoms, Aggregation Effects, and Hydrogen Bonds Restrict Movement. | The synergistic effect of the "four-in-one" strategy, which includes the heavy atoms effect, coordination-induced emission (CIE), hydrogen bonds locking effect, and efficient antenna effect, was utilized to significantly enhance the light yield of Tb-SDB-MOF X-ray scintillator. Notably, the efficient heavy atoms effect... |
41882918 | Lithium-Modified UiO-66-2OH for Improved D<sub>2</sub>/H<sub>2</sub> Separation Performance. | Efficient separation of hydrogen isotopes (D<sub>2</sub>/H<sub>2</sub>) is critically important for applications such as nuclear fusion, but it remains highly challenging due to their nearly identical physicochemical properties. In this work, a scalable UiO-66-2OH metal-organic framework was synthesized via a simple an... |
41882783 | The diagnostic performance of point-of-care tests for serum amyloid A and C-reactive protein in lame sows. | <h4>Background</h4>For acute phase proteins to be implemented in routine diagnostics for pig herds, a fast, reliable, and portable point-of-care test is required. Therefore, this study aimed to evaluate the diagnostic performance of two point-of-care tests on lame gestating sows. The two tests were the Cobas b101 CRP t... |
41882304 | In situ assembled MIL-101(Cr) composite functionalized with chitosan and tannic acid as an efficient adsorbent for Pb<sup>2+</sup> removal from aqueous solutions. | The uncontrolled release of lead (Pb<sup>2+</sup>) into water bodies presents a major risk to both environmental integrity and human health, owing to its high toxicity, long-term stability, and tendency to accumulate in living organisms. Addressing this challenge, the present study reports the synthesis of a novel, eco... |
41882187 | PEO-sheathed liquid jets increase sample delivery stability for serial femtosecond X-ray crystallography. | Viscoelastic jets can be generated by the polyethylene oxide (PEO) sheathing of an aqueous solution using double-flow focusing nozzles (DFFNs) and represent an efficient method to deliver samples that are dispersed in low and medium-viscosity liquids for X-ray diffractive imaging experiments. Due to their micrometre di... |
41882019 | Quality evaluation, authentication, and redundancy analysis of wild and farmed silver carp based on amino acid profiles. | Elucidating quality disparities between farmed and wild fish is essential for the formulation of quality standards and the fulfillment of consumer expectations. In this study, wild and farmed silver carp (Hypophthalmichthys molitrix) were systematically collected across 12 sampling sites. Significant differences in ami... |
41881994 | Polymersomes preventing brain infiltration of CD177<sup>+</sup> neutrophils to mitigate hemorrhagic transformation post-tPA thrombolysis. | As an intravenous thrombolytic agent, tissue plasminogen activator (tPA) is limited by hemorrhagic transformation (HT) and a narrow therapeutic time window. Here we develop ROS-triggered polymersomes conjugated with fibrin-targeting CREKA peptide (CP) for tPA encapsulation. CP@tPA achieves efficient thrombosis targetin... |
41881950 | The cGAS-STING pathway in cancer: friend or foe. | The cGAS-STING pathway is crucial for recognizing aberrant DNA in the cytoplasm and activating the innate immune response. After detecting aberrant DNA in the cytoplasm, cGAS can catalyze the synthesis of cGAMP from ATP and GTP, which acts as a second messenger to engage STING and unleash type I interferons, thereby el... |
41881678 | Light-Active Anisotropic 2D MOF Heterojunctions for Fingerprint-Like Sensing of VOCs. | Traditional metal oxide semiconductor (MOS) and metal-organic framework (MOF) sensors typically rely on a single response signal, which is easily influenced by concentration and unable to effectively distinguish structurally similar volatile organic compounds (VOCs) at room temperature. To overcome these limitations, w... |
41881353 | Anthraquinone-Based Metal-Organic Framework with Proton Transfer for Enhanced H<sub>2</sub>O<sub>2</sub> Photosynthesis. | Photocatalytic oxygen reduction offers a green route to hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) production, yet practical efficiency is often limited by insufficient visible-light harvesting, fast charge recombination, and the kinetic mismatch between proton supply and interfacial electron transfer. Inspired by ... |
41881029 | Programmable Lipid Functionalization of Nucleic Acid Nanoparticles Modulates Liver Cell-Type Targeting. | Nucleic acid nanoparticles (NANPs) fabricated by using DNA origami are an emerging delivery vector for nucleic acid therapeutics. Despite their advantages over other nanomaterials that include controlled spatial presentation of targeting ligands such as lipids and sugars, understanding their cell targeting and uptake m... |
41880985 | Peptide-Incorporated Biomaterials Promote Regeneration of Peripheral Nerve Injuries. | Peripheral nerve injury (PNI), commonly caused by various forms of trauma, may lead to numbness, muscle weakness, and even loss of motor and sensory function. Autologous nerve transplantation remains the clinical "gold standard" for repairing peripheral nerve defects. However, it has inherent limitations, including lim... |
41880989 | Conductive Reflow-Resistant Self-Healing Nanocomposite-Structured Adhesives for Reliable and Versatile Bioelectronic Interfaces. | Skin-like wearable bioelectronics should exhibit stable adhesion, benign detachment, stretchability, and self-healability to meet the demands of future user-interactive electronic skin applications. Despite recent rapid advances in self-healable adhesive electronic materials, inherent flowability and fast chain dynamic... |
41880650 | Photoresponsive Superlubricity Achieved by a Host-Guest Hydrogel Releasing PEG for Ocular Applications. | Prolonged exposure to visible light can disrupt tear-film stability and compromise ocular lubrication, potentially leading to eye fatigue, dryness, and the development of dry-eye disease, thereby highlighting the need for durable and long-lasting ocular lubrication. In this study, we develop a photoresponsive double-ne... |
41880560 | Structural insight of a photosystem I-CpcL-phycobilisome supercomplex from a cyanobacterium <i>Anabaena</i> sp. PCC 7120. | Phycobilisomes (PBSs) are supramolecular pigment-protein complexes composed of phycobiliproteins and linker proteins, serving as the major light-harvesting complexes that capture and transfer light energy to photosystem II (PSII) and photosystem I (PSI) in cyanobacteria and eukaryotic red algae. In cyanobacteria, a rod... |
41880514 | Machine learning-directed massively parallel programmable nucleic acid amplification. | Dynamic regulation of amplification efficiency is pivotal yet challenging in molecular diagnostics and DNA data storage. Here, we develop a thermodynamics-based approach to achieve continuous and precise modulation of nucleic acid amplification efficiency. By decoupling sequence specificity from hybridization energy re... |
41880504 | Engineering low-symmetry colloidal crystals with optical anisotropies. | Engineered low-symmetry colloidal crystals are emerging as promising performance-enhancing alternatives to natural materials for optical devices. However, current synthesis methods cannot precisely control structural features such as the orientation of the optical axes in these crystals. Here, DNA-modified nanorods and... |
41880498 | Harnessing cooperative sorbate-sorbent adaptation in a flexible metal-organic framework for switchable hydrocarbon separation. | The pursuit of selective adsorption for separating molecules with similar shapes and interactions remains a formidable challenge. This work harnesses a powerful, previously unrecognized mechanism in a flexible metal-organic framework (Flex-Cd-MOF-3) to achieve switchable adsorption selectivity. Specifically, Flex-Cd-MO... |
41880376 | Neutralization of SARS-CoV-2 by IgM-14 via engagement of two distinct spike epitopes. | Engineered immunoglobulin M (IgM) antibodies typically exhibit superior neutralization potency and avidity compared to their parental IgG counterparts, primarily due to multivalent binding to repeated epitopes on a targeting antigen. In this study, we characterize the neutralization breadth and mechanism of action of I... |
41880349 | Fis suppresses late-stage virulence gene expression in Yersinia pseudotuberculosis at environmental temperatures. | The nucleoid-associated protein Fis is a key transcriptional regulator in Gram-negative bacteria that supports rapid adaptation to environmental changes. In Yersinia pseudotuberculosis, Fis plays a critical, yet poorly understood role in virulence. Here, we present a comparative transcriptomic analysis of Y. pseudotube... |
41880316 | Microalgal colony blot: A simple and rapid method for direct detection of recombinant protein production in microalgae colonies. | Microalgae have emerged as a versatile biotechnological platform, promising to become an efficient source of commodities such as food, feed, and biofuels, but these organisms have also sparked profound scientific and commercial interest for their potential in producing high-value recombinant proteins. Recombinant gene ... |
41880107 | Engineering of Corynebacterium glutamicum for the enhanced production of optically pure (meso)-2,3-butanediol. | 2,3-Butanediol (2,3-BDO) is a versatile platform chemical with diverse applications in cosmetics, pharmaceuticals, agricultural and food manufacturing. Among its stereoisomers, optically pure (meso)-2,3-BDO is particularly valuable; however, achieving high titers with stereoselectivity remains challenging in convention... |
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