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41874365 | DNA-PK interacts with cyclic dinucleotides and inhibits type I interferon responses. | Inflammatory signal termination is critical for the maintenance of homeostasis. Cyclic dinucleotides (CDNs) are second messengers that trigger inflammatory responses through the activation of the stimulator of IFN genes (STING) signaling platform. No broad-acting direct regulator of intracellular CDNs has been identifi... |
41874194 | PEX19 restricts porcine deltacoronavirus replication through farnesylation-dependent and -independent mechanisms. | Peroxisomes are vital cellular organelles that play critical roles in metabolism, immune regulation, and disease pathogenesis. As a key receptor for peroxisomal membrane proteins, peroxisomal biogenesis factor 19 (PEX19) is essential for peroxisome biogenesis. In this study, we identify PEX19 as a novel host restrictio... |
41874045 | Host-specific functional evolution of seal influenza A virus NS1 protein following avian-to-seal transmission. | Marine mammals, particularly seals, are susceptible to both avian and human influenza A viruses (IAVs), making them potential intermediates for zoonotic virus emergence. In recent decades, repeated transmissions of avian influenza viruses (AIVs) from wild aquatic birds, their natural reservoir, have caused significant ... |
41873950 | Adaptor protein supersaturation drives innate immune signaling and cell fate. | How minute pathogenic signals trigger decisive immune responses is a fundamental question in biology. Classical signaling often relies on ATP-driven enzymatic cascades, but innate immunity frequently employs death fold domain (DFD) self-assembly. The energetic basis of this assembly is unknown. Here, we show that speci... |
41873951 | Hydro-Torsional Compaction for Scalable Production of Aramid Nanofiber Threads with Densely Assembled Double-Helical Nanostructures. | Synthetic replication of biological materials like spider silk, cellulose, and collagen remains challenging owing to the entropic cost of aligning high-aspect-ratio chains into compact, load-bearing structures. These barriers cause misalignment, voids, and poor inter-fiber cohesion in macroscale materials. We report a ... |
41873930 | Interphase Self-Optimization Enables Stable Magnesium Anode in Hydrogel Electrolyte. | Magnesium metal is a promising anode material for high-energy and cost-effective aqueous batteries, but the issue associated with corrosion reaction and surface passivation is more severe than the commonly studied metals such as Zn. Current strategies either rely on aggressively dissolving corrosion products with the s... |
41873851 | π-π Stacking-Directed Crystallographic Orientation of Zn Elec-trodeposition for Ultralong-Life Anodes. | The practical deployment of aqueous zinc (Zn) metal batteries is hindered by non-uniform Zn deposition, where rampant dendrite growth and parasitic reactions lead to rapid performance decay. It remains a fundamental barrier to maintain control deposition behavior for reliable operation, especially under demanding pract... |
41873846 | Preparation, characterization of geraniol/HP-β-CD inclusion complex and its acute toxicity evaluation in mice. | <h4>Objective</h4>This study prepared a geraniol (Ger)/hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion complex (IC) and evaluated its acute toxicity in mice to support applications in functional foods and pharmaceuticals..<h4>Significance</h4>Poor stability and irritation limit Ger use; HP-β-CD complexation improves ... |
41873793 | Transfer-Matrix Framework for Modeling Mid-Infrared Vibrational Circular Dichroism Spectra. | We present a rigorous electromagnetics-based theoretical model for mid-infrared (mid-IR) absorption and vibrational circular dichroism (VCD) spectra of homogeneous samples. The formalism based on 4 × 4 transfer-matrix methodology enables quantitative interpretation of the VCD signal for samples of varying thicknesses a... |
41873670 | Photoregulated Sequential Chemical Relay via Artificial Nanochannels. | Development of synthetic ion transporters and in situ chemical reaction-mediated communication systems that mimic cellular signaling processes is crucial for preparing protocells to understand complex cellular signaling and related functions. Although there have been advances in synthetic ion transporters, the role of ... |
41873667 | Template-Directed Synthesis of MOF-Based Sensors for Ultratrace Gas Sensing. | Conductive metal-organic frameworks (c-MOFs) offer great promise for sensing applications, yet the controlled fabrication of c-MOF thin films with defined morphology, thickness, and even orientation remains a significant challenge. Herein, we describe a template-directed strategy to enable the in-situ growth of a serie... |
41873566 | Phytochemical-based nanomedicine as a promising therapeutic strategy for erectile dysfunction. | <h4>Abstract</h4>Erectile dysfunction (ED) is a common condition among aging men, often associated with metabolic disorders, diabetes mellitus, hypertension, oligozoospermia, cardiovascular disease, sedentary lifestyles, chronic infections, and inflammation. A major therapeutic challenge is the inefficient delivery of ... |
41873482 | Arm-Length-Controlled CsPbBr<sub>3</sub> Nanocrystals for Tunable Optical and Assembly Behavior. | Colloidal cesium lead bromide (CsPbBr<sub>3</sub>) nanocrystals (NCs) are excellent candidates for various photonic and optoelectronic applications due to their bright and stable green emission. Here, we establish arm length control as a central structural parameter that governs both the optical properties of individua... |
41873024 | Review of the Effects of Anesthetic Techniques and Medications on the Immune Response During the Perioperative Period. | Anesthetic techniques have a measurable influence on immune function during the perioperative period, with potential consequences for infection risk, tissue repair, and oncological outcomes. The key pathways implicated include mTOR (mechanistic target of rapamycin), NF-kappaB (nuclear factor kappa-light-chain-enhancer ... |
41843736 | Single-cell landscape of piglet lung response with <i>Actinobacillus pleuropneumoniae</i>. | Pulmonary fibrosis is a prevalent, chronic, and fatal illness that poses considerable risks to life and health. <i>Actinobacillus pleuropneumoniae</i> (<i>A. pleuropneumoniae</i>) is an archetypal bacteria responsible for inducing significant pulmonary fibrosis, resulting in substantial economic losses in the pig indus... |
41821477 | Hydrophobic pores in a calcium-based MOF enable one-step ethylene purification from C<sub>2</sub>H<sub>2</sub>/CO<sub>2</sub>/C<sub>2</sub>H<sub>4</sub> mixtures. | Herein, we report the construction of a microporous calcium-based metal-organic framework based on a methyl-functionalized tetracarboxylate linker. The compound HIAM-204 features hydrophobic pores exhibiting precise size/shape compatibility with C<sub>2</sub>H<sub>2</sub> and CO<sub>2</sub>, affording high low-pressure... |
41805252 | Surface engineering of SRMIST-2 using amine-functionalized polyhedral oligomeric silsesquioxane for tunable wettability and sustainable oil-water separation. | Oil spills and industrial pollutants present a severe and persistent threat to aquatic ecosystems and global environmental health. These contaminants not only degrade water quality but also initiate a cascade of environmental issues that can impact global climate patterns. To address this urgent challenge, metal-organi... |
41804976 | Competing but coexisting: sulfate- and potassium-induced supramolecular motifs in squaramide-based receptor complexes. | We explore the coexistence and interplay of two distinct supramolecular motifs within a single receptor molecule combining squaramide and benzo-15-crown-5 ether domains. These heteroditopic systems display a dual recognition behavior, forming either sandwich-type potassium complexes or 4 : 1 sulfate assemblies, dependi... |
41801158 | Excitation-wavelength-dependent emission of a luminescent host-guest Zn(II) metal-organic framework for high-performance white LEDs. | This work presents a novel luminescent host-guest Zn(II) metal-organic framework (CNU-404) with blue-light-excitable excitation-wavelength-dependent emission. It serves as a blue-cyan-green tri-color phosphor, enabling white LEDs upon blue-chip excitation, achieving an ultrahigh CRI (Ra 95.7), and offering a new strate... |
41790055 | Blue-light-driven aerobic oxidation <i>via</i> a superoxide radical-generating zinc(II)-organic framework photocatalyst. | The development of sustainable and efficient photocatalytic systems for aerobic oxidation is a crucial challenge in the field of green chemistry. In this study, we present the rational design and synthesis of a novel zinc(II)-organic framework (Zn-1D) by incorporating anthracene-based photoactive ligands with zinc(II)-... |
41790038 | Formation and tuning of a pillar porous-layered framework into a pillar double-channelled framework. | Precise structural regulation is crucial for tailoring the functions of metal-organic frameworks (MOFs). In this work, we report a subtle pillar-engineering strategy, which involves changing the hexafluoride anion from SiF<sub>6</sub><sup>2-</sup> to TiF<sub>6</sub><sup>2-</sup>, which can trigger a dramatic topologica... |
41789735 | Dimensional engineering of 3D hierarchical camellia-like supramolecular organic frameworks for enhanced electrochemiluminescence. | A 3D hierarchical camellia-like supramolecular organic framework (CSOF) was successfully constructed to suppress nanosheet stacking and aggregation, enhancing electrochemiluminescence. Combined with entropy-driven signal amplification, CSOF-based electrochemiluminescence biosensors enable femtomolar-level detection of ... |
41789573 | Rational development of a drug-delivery device based on MOF UiO-66 for calcium-channel-blocker drugs. | The administration of drugs with low solubility or absorption, such as the calcium-channel-blocker (CCB) drugs amlodipine, nifedipine, and nimodipine, affects the management of complicated health conditions related to cardiovascular diseases. The development of a drug-delivery device based on MOFs is a rising topic. Th... |
41783934 | Expansion of pore size and interlayer distance in a Kagomé-type MOF engineered through the geometric features of azulene. | A two-dimensional Kagomé-type MOF (Azln-KGM) incorporating 1,3-azulenedicarboxylate ligands was synthesized. Compared with reported isomorphous MOFs featuring a benzene motif, Azln-KGM exhibited an enhanced maximum adsorption capacity and gate-opening behavior accompanied by larger structural changes. |
42006362 | Thermo-pH dual-responsive nanocarriers enable multiscale-controlled resveratrol release via molecular remodeling and electronic decoupling. | Resveratrol (RES) suffers from poor solubility and non-specific distribution, motivating the development of delivery systems with controllable stability and stimulus responsiveness. Here, we construct a hybrid nanocarrier composed of poly(N-isopropylacrylamide) and poly(L-lysine) that exhibits coupled temperature and p... |
41988498 | Controlling triplet-pair formation in acene-bridged trimers through locally excited-charge-transfer state mixing. | Singlet fission (SF) offers a pathway to surpass conventional efficiency limits in photovoltaics, yet how bridge-chromophore coupling governs locally excited/charge-transfer state (LE-CT) mixing and thereby the multiexciton yield remains elusive. We design three systems, TIPS-BT0, TIPS-TAT, and Encap-TAT, that progress... |
41970895 | Advances in Leaching Agents for Indirect CO<sub>2</sub> Mineralization. | Industrial solid waste contains various metal elements that react with CO<sub>2</sub>. Its utilization for CO<sub>2</sub> mineralization, an important part of CCUS technology, enables permanent CO<sub>2</sub> storage and solid waste resource recovery, while delivering significant environmental and economic benefits. As... |
41970889 | Emerging Trends and Future Prospects of the Catalytic Conversion of Syngas to Higher Alcohols. | The catalytic conversion of syngas, a mixture of carbon monoxide (CO) and hydrogen (H<sub>2</sub>), into higher alcohols (C<sub>2+</sub>OH) in a single step holds great promise for sustainable fuels and chemical production. These higher alcohols (HAs) serve as value-added and versatile intermediates for a wide range of... |
41970874 | Investigation of Chloride Binding Abilities of Symmetric Squaramides. | In this work, three symmetric squaramide derivatives were synthesized, and their anion-binding properties were systematically investigated. The binding properties of squaramides <b>I</b>-<b>III</b> with anions were determined by spectroscopic titration in DMSO-<i>d</i> <sub>6</sub> using tetrabutyl ammonium salts. Duri... |
41970851 | Phase Behavior and Percolation of a Primitive Model of Laponite Suspension: Wertheim's Thermodynamic Perturbation Theory with Anisotropic Reference Particles. | The computation of the properties of associative fluids within Wertheim's multidensity thermodynamic perturbation theory becomes particularly challenging when the reference system is composed of strongly anisotropic, nonspherical particles. We develop a simple and efficient framework that combines thermodynamic perturb... |
41970834 | Derived UV-Vis Absorbance Spectra for Facile Analysis of Optically Dense Samples. | The UV-vis absorption bands of optically dense samples are broad, overlapped, saturated, nonlinear, and have minor peaks suppressed; often, the minor peaks are representative of the analytically noteworthy lowest-energy electronic transitions (S<sub>0</sub> to S<sub>1</sub>). Conventional UV-vis methods limit the accur... |
41970252 | Ultrasmall Prussian blue-integrated cryogel for enhanced ROS scavenging and immunomodulation via cGAS-STING inhibition in wound healing. | Intractable wounds remain a major clinical challenge due to persistent oxidative stress, dysregulated inflammation, and impaired macrophage polarization. Here, we develop a therapeutic cryogel by integrating ultrasmall Prussian blue (USPB) nanozymes into a GelMA-quaternary ammonium chitosan methacryloyl matrix via cryo... |
41963195 | Engineering black phosphorus and its composites for advanced anodes in alkali metal-ion batteries: progress and challenges. | The rapid advancement of energy storage technologies has spurred the search for advanced anode materials for alkali metal-ion batteries (AMIBs). Black phosphorus (BP), a layered phosphorus allotrope whose few-layer form (phosphorene) is a two-dimensional (2D) material, has garnered significant attention due to its high... |
41956693 | Unraveling the stability of fish collagen: A review of assembly mechanisms, decisive factors, and regulatory strategies from natural tissues to in vitro gels. | Fish collagen, mainly derived from by-products of fish processing, such as skin, bones, and swim bladders, possesses significant economic value. However, its poor gel stability severely restricts its applications in the food industry. This review summarizes the self-assembly and gelation mechanisms of fish collagen, di... |
41953719 | Microneedle-based theranostics for melanoma: Advances and outlook. | Melanoma represents a highly aggressive malignancy that poses persistent challenges for clinical diagnosis and treatment. Although surgical intervention remains the primary therapeutic approach, the potential risk of postoperative recurrence and surgical complications underscores the critical importance of adjuvant the... |
41948730 | Hyaluronic acid: emerging roles and biomaterial innovations in Alzheimer's and Parkinson's disease therapy. | Hyaluronic acid (HA) is a key component of the extracellular matrix (ECM). Owing to its anti-inflammatory properties, biocompatibility and ability to contribute to ECM remodeling, HA is considered a promising therapeutic candidate for neurodegenerative diseases. This review summarizes the application of HA to treat Alz... |
41948610 | Nanoengineered phytochemicals overcome blood-brain barrier constraints in neurodegenerative disorders. | Neurodegenerative disorders represent a growing global health burden and remain largely incurable, with current therapies providing only symptomatic relief and limited disease modifications. A major obstacle to effective treatment is the inability of many neuroprotective agents to reach the brain at therapeutically rel... |
41948578 | Global trends and hotspots of natural medicines for pathological scar treatment: a visualized bibliometric analysis (2008-2025). | <h4>Background</h4>The therapeutic role of natural medicines in pathological scars has received widespread attention in recent years. However, there is no systematic bibliometric study to analyze the research hotspots and trends in this field.<h4>Purpose</h4>This study aimed to provide researchers with a comprehensive ... |
41948531 | Correction: Dysregulated interferon signaling and hyperinflammation upon <i>FCGBP</i> knockdown in goat bronchial epithelial cells infected with <i>Pasteurella multocida</i>. | [This corrects the article DOI: 10.3389/fvets.2026.1761935.]. |
41948334 | Targeting the tripartite axis of immune-metabolic-spatial crosstalk to overcome therapy resistance in breast cancer. | Therapeutic resistance remains the principal cause of mortality in breast cancer. While the tumor microenvironment (TME) is a key contributor, therapies targeting isolated TME components, whether immune, metabolic, or spatial, have largely failed due to compensatory adaptations and ecological resilience. This review sy... |
41947916 | Mining personalized core traditional Chinese medicine prescriptions for rheumatoid arthritis and elucidating their mechanisms via frequent closed Itemset compression and multilevel network pharmacology. | <h4>Introduction</h4>Rheumatoid arthritis (RA) is a complex immune-mediated inflammatory disease involving multiple dysregulated signaling pathways and marked inter-individual heterogeneity in treatment response. In real-world clinical practice in China, traditional Chinese medicine (TCM) is widely used for RA manageme... |
41930170 | Nanoliposome-Encapsulated Semiconductor Particles and Arsenic Trioxide Synergistically Enhance Chemo-Photothermal Therapy for Lung Cancer. | <h4>Objectives</h4>Combined chemotherapy and photothermal therapy (PTT) represents a promising approach for enhancing cancer treatment efficacy. This study aimed to develop arsenic trioxide (ATO) and poly(cyclopentadithiophene-alt-benzothiadiazole) (PCPDTBT)-loaded nanoparticles (ATO/PCPDTBT@NPs) to evaluate their syne... |
41930150 | Next-Generation Hydrogel Platforms for Effective Localized Cancer Therapy: Advances in Biologics, Immunotherapeutics, and Gene Delivery. | Despite remarkable advances in nanomedicine, localized delivery of advanced cancer therapeutics remains underexploited. Advanced therapies based on biopharmaceuticals, immunotherapy, or gene therapy have revolutionized oncology. Yet, their systemic administration is often associated with limitations such as poor site-s... |
41918614 | An experimental perspective on symmetry breaking and the singlet fission mechanism in solid-state materials. | Singlet fission (SF) materials have attracted attention in the field of solar cell research for decades. The deployment of novel and efficient SF molecules necessitates solution processibility and high SF yield in the solid state. SF materials can be integrated with silicon or organic photovoltaics, most commonly as a ... |
41908096 | A Review of SIK2 in Ovarian Cancer: Function and Emerging Targeted Therapies. | Ovarian cancer, a common gynecologic malignancy, is associated with a poor prognosis owing to difficulties in early detection, high recurrence rates, and frequent therapy resistance. Salt-inducible kinase 2 (SIK2), a serine/threonine kinase frequently overexpressed in ovarian cancer, has emerged as a potential key driv... |
41907491 | Optimizing Osteoarthritis Management - Therapeutic Efficacy and Evaluation of Intra-Articular Triamcinolone Acetonide Injection. | Osteoarthritis (OA) is a common degenerative joint disease that often leads to pain and diminished quality of life in patients. For end-stage osteoarthritis, surgical intervention remains the only effective treatment. However, for the majority of patients, surgery is not the initial consideration. The management of ost... |
41907375 | Nanodynamic Therapy in Colorectal Cancer: Engineering Precision Immunotherapy and Multimodal Synergy. | Colorectal cancer (CRC) is a common malignancy that remains difficult to control with surgery, chemotherapy, radiotherapy, and targeted therapy. These challenges arise from tumor heterogeneity, therapy resistance, and frequent relapse or metastasis, especially in advanced disease. In addition, precision approaches are ... |
41907376 | Sequential Release of mRNA Complex and T Cells by a Double-Layered Implantable Scaffold for Combination Therapy of Head and Neck Squamous Cell Carcinoma. | <h4>Background</h4>Head and neck squamous cell carcinoma (HNSCC) is associated with considerable morbidity and mortality, necessitating the development of novel therapeutic strategies. Adoptive cell therapy (ACT) and gene therapy are validated strategies for HNSCC treatment; however, both strategies have limitations wh... |
41907372 | Antimicrobial Hydrogel for Diabetic Wound Treatment. | Diabetic wound infections pose a significant clinical challenge. Chronic wounds associated with diabetes mellitus exhibit delayed healing and, if not managed appropriately, are highly susceptible to infections that may lead to life-threatening complications in severe cases. Antimicrobial hydrogels have become promising... |
41907218 | The Interaction Between Ferroptosis and Necroptosis in Acute and Chronic Kidney Diseases. | Kidney disease represents a major non-communicable disease characterized by complex pathogenesis and limited therapeutic options. Current research has revealed multiple underlying mechanisms, including ferroptosis and necroptosis, which play important roles in acute kidney injury (AKI) and chronic kidney disease (CKD).... |
41903423 | Impact of crystalline type on starch-polyphenol complexation under sequential gelatinization and ultrasonication. | Inhibiting starch digestion is an effective approach to regulate postprandial blood glucose levels, and ultrasound assisted modification has emerged as a promising non-thermal strategy to tailor starch structure and functionality. In this study, sequential treatment of gelatinization and ultrasonication at varying ampl... |
41902172 | Electrochemical Biosensing Platforms for Rapid and Early Diagnosis of Crop Fungal and Viral Diseases. | Crop fungal and viral diseases cause annual economic losses exceeding USD 150 billion globally, demanding rapid, sensitive, and field-deployable diagnostic technologies. This review critically evaluates recent advances in electrochemical biosensing platforms for early crop pathogen detection, focusing on immunosensors,... |
41902167 | Design, Implementation, and Advances in Indirect SERS Sensors for Biomedical and Human-Health-Related Analyte Detection. | Novel, accurate molecular diagnostics are driving new advances across medicine, public health, and environmental monitoring. Surface-enhanced Raman spectroscopy (SERS) nanotags are powerful platforms for ultrasensitive, multiplexed, and quantitative detection of molecular targets. This review focuses on indirect sensin... |
41901903 | In Situ Growth of MIL-100(Fe) on Coconut Shell Activated Carbon for High-Efficiently Removal of Microplastics from Water. | The widespread use of plastics has inevitably led to the accumulation of persistent plastic debris in aquatic systems, where gradual fragmentation generates microplastics (MPs) that threaten ecological and biological health. Their small size, chemical stability, and resistance to degradation make effective removal part... |
41901794 | Multi-Epitope DNA-Based Feline Immunodeficiency Virus Vaccine Construct Designed by Immunoinformatic and Machine Learning Tools as a Surrogate Model for HIV Vaccine Development. | Feline immunodeficiency virus (FIV) is a lentivirus that exhibits significant structural and pathological similarities to human immunodeficiency virus (HIV), establishing it as a valuable model for HIV vaccine development. In this study, artificial intelligence (AI) and immunoinformatics were employed to design a novel... |
41901364 | Pleiotropic Bioactivity of Caterpillar Fungus, Orange Cordyceps, and Cordycepin: Insight from Integrated Network Pharmacology and Food and Drug Regulatory Framework. | <b>Background/Objectives:</b> The medical mushroom <i>Ophiocordyceps sinensis</i> (Caterpillar Fungus), known for its ability to enhance "vitality," is one of the most popular medicines in Asian traditional medical systems. According to the Chinese <i>Pharmacopeia</i>, <i>O. sinensis</i> is standardized for its adenosi... |
41901049 | Integrative Pharmacological and Computational Analysis of <i>Abelmoschus esculentus</i> Phytochemicals: Enzyme Inhibition, Molecular Docking, and Dynamics Simulation Against Key Antidiabetic Targets. | The present work set out to examine the antidiabetic capacity of <i>Abelmoschus esculentus</i> (okra) fruit extract through a combined experimental and computational framework. Enzyme inhibition assays were carried out against four metabolic targets, and IC<sub>50</sub> values stood at 7.66 ± 0.31 mg/mL for alpha-gluco... |
41900484 | Monosodium Glutamate Inhibits <i>Pseudomonas aeruginosa</i>-Induced Acute Lung Injury by Targeting the Type III Secretion Systems and Modulating Host Immunity. | The opportunistic pathogen <i>Pseudomonas aeruginosa</i> poses a serious threat to immunocompromised patients. Monosodium glutamate (MSG), a widely used flavor enhancer, has been reported to possess anti-inflammatory and antioxidant properties. However, its therapeutic potential and mechanism against <i>Pseudomonas aer... |
41900274 | Enhanced Fringing Field Micro-Moisture Sensor with Elements Optimization. | This research demonstrates the principle and optimization methodology to create economic and miniaturized high-resolution micro-moisture sensors. The interdigitated fringe electric field-based moisture measurement principle is firstly investigated to sketch the key parameters of printed circuit board (PCB)-based sensor... |
41900160 | Synthesis and Biological Evaluation of Curvularin-Type Derivatives with Potential Anti-Inflammatory, Anticancer, and Antimicrobial Activities. | Curvularins, a class of macrocyclic lactones, have cytotoxic, antimicrobial, and anti-inflammatory properties. Curvularin, a 12-membered macrolactone, was used as a scaffold to design and synthesize structurally modified analogues to investigate structure-activity relationships and improve biological efficacy. Three se... |
41900157 | Efficient Ultrasound-Assisted Extraction of Four Major Aescins from <i>Aesculi Semen</i> Seeds Using Deep Eutectic Solvents. | Low extraction efficiency limits the availability and application of aescins, which exhibit various pharmacological activities. Here, we optimized parameters for ultrasound-assisted extraction of aescins from <i>Aesculus chinensis</i> seeds using deep eutectic solvent (DES)-water mixtures. Seven DES formulations were s... |
41900152 | Recent Advances in Functionalized Nanomaterials: Design, Synthesis, Characterization, and Application. | The rapid evolution of nanotechnology has positioned functionalized nanomaterials at the forefront of modern materials science and engineering [...]. |
41899486 | Biotransformation of Maclekarpine E in Rats: CYP2C19-Mediated Metabolism, Fecal Enrichment, and Network Pharmacology-Based Anti-Ulcerative Colitis Prediction. | Maclekarpine E is a minor alkaloid from <i>Macleaya</i> species with reported in vitro anti-inflammatory activity, but its in vivo metabolism remains unexplored. This study investigated the metabolic fate of maclekarpine E in rats and evaluated the potential pharmacological relevance of its metabolites. Maclekarpine E ... |
41898775 | Ligand-Dependent and -Independent Functions of Activation Function 1 of Progesterone Receptor in Genome-Wide Gene Regulation and in Cell Proliferation and Apoptosis of Breast Cancer Cells. | Progesterone receptor (PR) regulates gene expression through recruiting coregulators and general transcription factors by activation functions AF1 and AF2. AF1 localizes to the non-conserved and disordered N-terminal domain and is believed to facilitate tissue- and gene-specific activity. Our previous proteomic analysi... |
41898769 | Pyridinium-Fused 1,3-Selenazoles via Cyclizations of 2-Pyridylselenyl Chloride with Alkynes: Synthesis, Structures, and Antifungal Properties. | We report a straightforward and versatile synthetic route to pyridinium-fused 1,3-selenazoles via the electrophilic cyclization of 2-pyridylselenyl chloride with alkynes. The reaction proceeds efficiently under mild conditions with representative terminal and internal alkynes. While the cyclization exhibits high regios... |
41898768 | Physiological Implications of Pancreatic Amyloid Polypeptide Aggregation and Its Inhibition by Melatonin. | Type 2 Diabetes (T2D) is characterized by the toxic aggregation of human islet amyloid polypeptide (hIAPP or amylin) within pancreatic β-cells. IAPP is also a neuropancreatic hormone that plays a significant role in Alzheimer's disease (AD) by co-depositing with amyloid-beta (Aβ) and Tau, supporting the Type 3 Diabetes... |
41898744 | Silk-Fibroin-Based Strategies for Myocardial Infarction Repair: A Comprehensive Review. | Myocardial infarction is a major cardiovascular event that leads to heart failure and death. Although current vascular regeneration and pharmacological therapies can salvage some myocardial tissue, they cannot effectively reverse established necrosis, fibrosis, or adverse ventricular remodeling, thus necessitating nove... |
41897415 | Effects of Naringenin in Preclinical Models of Breast Cancer. | Breast cancer is the most commonly diagnosed cancer among women, with approximately one in eight women developing the disease during their lifetime. Despite advancements in current treatment options, breast cancer was responsible for an estimated 670,000 deaths worldwide in 2022. This highlights the urgent need for the... |
41895178 | Norepinephrine-coated defect-engineered chiral MOF enables synergistic enantioseparation in capillary electrochromatography. | Chiral defect engineering offers a versatile strategy for constructing chiral metal-organic frameworks (CMOFs) with tunable structures and chiral recognition, thereby enhancing enantiomeric resolution. However, the stable immobilization of defect-engineered CMOFs onto the inner surfaces of capillaries-crucial for fabri... |
41894849 | Mechanical properties enhanced injectable reactive oxygen species-responsive double network hydrogel promotes bone regeneration for the treatment of periodontitis. | Periodontal bone defects serve as a significant clinical challenge. They typically fail to heal spontaneously through the body's innate repair mechanisms. Physiological levels of reactive oxygen species (ROS) play a crucial role in antimicrobial defense. However, excessive ROS in periodontal bone defects can severely a... |
41893819 | Lambda Phage-Based Antibody-Stimulating Platform Targeting EGFRvIII. | <h4>Background/objectives</h4>Bacteriophage-based display has been utilized for a variety of purposes, such as to assemble protein libraries and conduct biopanning. We have created a modified lambda (λ) bacteriophage platform, ideal for the display and delivery of proteins. Our system utilizes counter-selection recombi... |
41893817 | Structural Design of T-Cell Epitope-Based mRNA Vaccine Constructs Determines the Quality of T-Cell Immunity and Protective Efficacy Against SARS-CoV-2 in Mice. | <h4>Background/objectives</h4>Epitope-based mRNA vaccines represent a promising strategy for eliciting protective T-cell immunity against SARS-CoV-2 and as well as for non-infectious mRNA-based vaccines. However, how the structural architecture of vaccine constructs (including epitope arrangement, linker composition, s... |
41893295 | Membrane Separation Techniques: Advances, Challenges, and Future Avenues. | The separation of substances from one another, such as distillation, extraction, absorption, crystallization, and drying, comprises a main sector of the industry engineering field and has substantial potential to play an increasingly important role in the application of separation technologies and innovations [...]. |
41893261 | Cellulose-Based Nanoparticles Processed from Agricultural Waste Biomass-A Review. | The nanoparticles processed from non-edible crop materials and residues have evoked great use in the food and non-food industry. The diversity in agricultural waste biomass and differences in extraction techniques account for variations in end-product properties, and would require examination of waste crop types (sourc... |
41893259 | Hexagonal Close-Packed Au@Ag Superlattices for Versatile and Cost-Effective SERS Platforms. | The rapid fabrication of low-cost surface-enhanced Raman scattering (SERS) substrates is highly desirable for chemical and biological sensing. Existing customized SERS substrates, such as Au or Ag nanostructures produced by physical deposition, frequently involve complex fabrication routes, which limits the scalability... |
41892073 | Beyond Self-Assembly: Bioorthogonal 'Click' Chemistry Strategies for Robust Electrochemical Interfaces in Wearable Biosensors. | Electrochemical biosensors integrated into wearable devices have revolutionized the technology in terms of health monitoring and diagnostic systems. However, when it comes to moving the devices from the laboratory to real-world environments, a critical problem emerges with the interface. The problem, in essence, is tha... |
41887145 | Metal-organic framework-enabled electrochemiluminescence biosensing: Design principles, signal amplification strategies, and performance trade-offs. | Electrochemiluminescence (ECL) is a highly sensitive analytical technique for trace-level biosensing, benefiting from a high signal-to-noise ratio, controllable excitation, and negligible background interference. However, practical ECL sensor performance is often constrained by sluggish interfacial electron transfer, i... |
41878656 | A review from fullerene dominance to non-fullerene innovation: theoretical perspective on next-generation organic photovoltaics. | The mechanical flexibility, solution processability, and the capability for low-cost processing of organic photovoltaics (OPVs) make them a viable class of next-generation solar energy technology. The design of effective electron acceptors that promote exciton dissociation, charge transfer, and long-term device stabili... |
41878654 | Continuous-flow synthesis of Pd(ii)-anchored amino-functionalised magnetic silica nanoparticles as a robust recyclable catalyst for aqueous Sonogashira cross-coupling. | A robust and magnetically recoverable palladium nanocatalyst, Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>-NH<sub>2</sub>-Pd(ii), was prepared through a scalable continuous-flow coprecipitation/silanisation strategy and evaluated in Sonogashira cross-coupling reactions in water. Although amino-functionalised magnetic si... |
41878648 | Enhanced biosensing of diabetes biomarkers by using rationally engineered carbon dots. | Carbon dots are quasi-spherical zero-dimensional nanomaterials. Small size and tunable optical properties render carbon dots with excellent biosensing ability. They exhibit fascinating excitation-wavelength-dependent emission properties, attributed to their sp<sup>2</sup>-carbon core. Presence of dopants alters the ene... |
41878644 | Unveiling the rheological secrets of hydrogels: from lab to clinical translation. | Hydrogels have garnered significant attention in the biomedical field due to their high-water absorption capacity, flexibility, and biocompatibility. However, the translation of laboratory achievements related to hydrogels into clinical applications remains slow. Core reasons for this phenomenon lies in the persistent ... |
41878642 | Deep eutectic solvents as recyclable media for metal removal from crude oil. | Crude oil contains trace metal species that impair refinery performance, poison catalysts, and contribute to environmental contamination. Conventional metal-removal processes, such as hydrotreating and solvent extraction, are energy-intensive and costly. In this study, deep eutectic solvents (DESs) were evaluated as al... |
41878634 | Computational Design of Broad-Spectrum Ebola Antibodies through Framework and Complementarity-Determining Region Synergistic Optimization. | <b>Background:</b> A major challenge in neutralizing antibody development lies in balancing improved potency with broad-spectrum efficacy, particularly for highly mutable pathogens such as the Ebola virus (EBOV). We developed a computational-experimental pipeline that combines multi-parameter in silico predictions with... |
41878147 | The effects of bioisostere substitution on the antimicrobial and physicochemical properties of supramolecular self-associating amphiphiles. | The rise of antimicrobial resistance (AMR) is one of the greatest health threats facing the world today. Supramolecular self-associating amphiphiles (SSAs) have shown potential for development as novel antimicrobial agents. We now move to explore the systematic use of nonclassical bioisosteres within these systems for ... |
41875888 | Pan-neurodegeneration proteomics reveals disease subtypes and molecular signatures. | Neurodegenerative diseases (NDs) pose clinical challenges due to their complexity and molecular heterogeneity. Here, we present a pan-neurodegeneration atlas (PanNDA) from multilayer, deep proteomic analysis of 2,279 human brain samples spanning 6 major NDs: Alzheimer's disease (AD), Lewy body dementia (LBD), frontotem... |
41873159 | Boron-Oxo Cluster-Based Hydrogen-Bonded Framework for Luminescent Tuning. | A zinc boron-oxo cluster-based structure ({Zn<sub>2</sub>(μ<sub>2</sub>-OH)(Dmg)<sub>4</sub>[B<sub>3</sub>O<sub>3</sub>(OH)] [B<sub>6</sub>O<sub>7</sub>(OH)<sub>2</sub>]}, <b>BOC-23</b>) was synthesized solvothermally using a dioxime (DmgH<sub>2</sub>) ligand. Two polyboroxole units ([B<sub>3</sub>O<sub>7</sub>(OH)] an... |
41873027 | An Organometallic [2]Catenane With Pt‒(di-NHC)‒Pt Units: A Topology-Driven Strategy for Enhanced Phosphorescence in Discrete Aggregates. | Mechanically interlocked molecules (MIMs) can be conceptualized as a distinct class of discrete and soluble aggregates, where the mechanical bond restricts selected intramolecular motions, thereby triggering emission enhancement analogous to aggregation-induced emission (AIE). Herein, we present phosphorescent MIMs bas... |
41873012 | Acetal[6]Arenes: Rigid Chirality-on-Annulus Macrocycles Promoting Charge-Transfer Co-Assembly With Exceptional (Chiro)Optical Properties. | Acetal[6]arenes (Ac[6]) are introduced as a new class of rigid chiral macrocyclic arenes in which carbon-centered chirality is embedded in a trioxabicyclo[3.3.1]nonane motif at macrocyclic waist. Ac[6] efficiently forms charge-transfer (CT) complexes with electron-deficient aromatic guests in both solution and the soli... |
41873021 | Implanting Lanthanide Luminophores Into Helical Scaffolds for Programmable Circularly Polarized Luminescence. | Integrating achiral luminophores into chiral supramolecular helices represents a promising route to strong circularly polarized luminescence (CPL). However, for lanthanide systems, efficient emitter loading and effective chirality induction remain challenging due to weak host-guest interactions and the shielded nature ... |
41872317 | Generating extended foldamer dye stacks and unravelling their evolving exciton dynamics. | In biomacromolecules, many amino acids or nucleotides are needed to obtain defined secondary structures and concomitant advanced functionalities. However, when researchers generate synthetic model analogues composed of dyes to predict the (photo-)functional properties of the respective solid-state aggregates they often... |
41872318 | Isolated and H<sub>2</sub>-reduced Anderson clusters catalyse low-temperature hydrogenation of CO<sub>2</sub> to methanol. | CO<sub>2</sub> hydrogenation, especially to methanol, is crucial to establishing sustainable closed-loop systems for carbon utilization. However, the difficulties of CO<sub>2</sub> activation at low temperatures and the ambiguity of structure-activity correlations are obstacles to reducing the energy consumption of the... |
41872249 | High efficiency of antibacterial activity-based Zn-Co@BTC MOF against Bacillus bacterial cells. | In this work, Zn-Co@BTC was synthesized under environmentally friendly, economical, and green conditions. It was prepared by the solvothermal method using zinc nitrate hexahydrate and cobalt nitrate hexahydrate as the metals, with benzene-1,3,5-tricarboxylate (BTC) as the ligand. The formation of Zn-Co@BTC MOF was conf... |
41872226 | Microporous MOF for simultaneous high thermodynamic and kinetic synergistic separation of propylene and propane. | Efficient separation of propylene from propane is a critical yet challenging industrial process. While rigid molecular sieves offer ideal selectivity, their narrow nanopores inherently constrain adsorption capacity and diffusion kinetics due to compromised thermodynamic-kinetic trade-offs. To address this, we report ZS... |
41872054 | K16F/E22F Mutation Promotes Oligomerization and Alters β-Sheet Topology of Aβ16-22 Peptides: Insights from Molecular Dynamics Simulations. | Amyloid-β (Aβ) aggregation into toxic oligomers and fibrils is a hallmark of Alzheimer's disease. The Aβ<sub>16-22</sub> fragment plays a critical role in the early stages of the aggregation of full-length Aβ peptides. Aggregation of Aβ<sub>16-22</sub> is primarily driven by hydrophobic interactions within the LVFF cor... |
41872041 | Orientation-Controlled MOF Membranes Enabling Switchable H<sub>2</sub>/CO<sub>2</sub> Separation. | Controlling the crystal orientation of metal-organic framework (MOF) membranes introduces a new dimension to chemical separations, as the alignment of anisotropic pore channels dictates the membrane's separation performance. Here, we demonstrate that the gas separation behavior of the MOF membrane can be reversibly swi... |
41872023 | Lipid Membrane-Coated Nanopipettes for Enhanced Resistive Pulse Sensing of Exosomes. | We report the use of lipid membrane-coated quartz nanopipettes to enhance exosome detection via resistive pulse sensing. By exploiting the self-assembly and compositional versatility of lipid molecules, nanopipettes were functionalized with lipid membranes comprising neutral and cationic lipids, with or without cholest... |
41871991 | Metamaterials from Plasma-Treated Block Copolymer Monolith. | This work demonstrates a facile method for fabricating thin-film metamaterials with high transmittance and superior impact resistance directly from plasma-treated polystyrene-<i>block</i>-polydimethylsiloxane (PS-<i>b</i>-PDMS) monoliths. Upon oxygen plasma treatment, the cocontinuous PDMS within the PS matrix is oxidi... |
41871974 | Structural and Mechanistic Heterogeneity of the Phase Separation and Aggregation of Full-Length TDP-43 is Governed by Environmental Conditions. | TAR DNA-binding protein 43 (TDP-43) is an essential physiological protein implicated in several fatal neurodegenerative disorders. Interestingly, the nature of TDP-43 aggregates varies across patients and disease conditions, suggesting an underlying heterogeneity in its self-assembly behavior. In this study, we investi... |
41871889 | Kinetics of dissolution and computational modeling of calcium oxalate monohydrate crystals in the presence of aqueous coffee bioactive extract compounds. | Urolithiasis, predominantly caused by calcium oxalate crystallization and dissolution, remains a major clinical challenge. This study explored the effect of coffee extract bioactive metabolites on synthetic COM crystals dissolution through combined experimental and computational approaches. LC-LTQ-MS/MS and NMR profili... |
41871300 | Coupled Hydrogen-Bond-Electrostatic Recognition of Phosphatidylglycerol Drives the Design of Resistance-Suppressing Miniature Peptidomimetics. | The emergence of multidrug-resistant (MDR) pathogens has urged us to find new antimicrobial strategies. Phosphatidylglycerol (PG) is an attractive bacterial-specific lipid target but is targeted by only one clinical agent, daptomycin. Yet daptomycin, like most reported PG binders, binds PG through an imprecise hydropho... |
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