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41871293 | Strong Metal-Support Interaction in Metal-Organic Framework (MOF)-Derived Multiphase TiO<sub>2</sub> Supports for Durable Pt Catalysts in Acidic Hydrogen Evolution. | Platinum-based electrocatalysts exhibit exceptional intrinsic activity toward the hydrogen evolution reaction (HER), but their practical deployment in water electrolysis is hindered by nanoparticle agglomeration, carbon-support degradation, and weak metal-support interaction (MSI). Here, porous TiO<sub>2</sub> supports... |
41871185 | Self-Assembled Nanomaterials for ER-Targeted Cancer Therapy: From Molecular Design to Therapeutic Applications. | The endoplasmic reticulum (ER) is essential for protein folding, lipid metabolism, calcium homeostasis, and cellular stress signaling. Cancer cells endure chronic ER stress from elevated metabolic demands and oxidative conditions, adapting ER pathways to evade apoptosis, while promoting growth, survival, and drug resis... |
41871182 | Magnesium-Chelating Vitamin C Nanostructures Induce p38 MAPK Vitcylation for Hepatic Fibrosis Therapy. | Vitamin C is essential for physiological health, yet its potential biological effects are limited by the difficulty of maintaining locally high concentrations under oxidative conditions. Here we developed a redox-stable magnesium-vitamin C coordination self-assembly encapsulated in a biomimetic liposomal shell. This na... |
41871140 | Predicting viral sensitivity to antibodies using genetic sequences and antibody similarities. | For genetically variable pathogens such as human immunodeficiency virus (HIV)-1, individual viral isolates can differ dramatically in their sensitivity to antibodies. The ability to predict which viruses will be sensitive and which will be resistant to a specific antibody could aid in the design of antibody therapies a... |
41871092 | Ex vivo and in silico evaluations of (E)-5-((benzo[d]thiazol-2-ylimino)(methylthio)methylamino)-2-hydroxybenzoic acid as a β3-adrenoreceptor agonist exerting anti-obesity, anti-inflammatory and hepatoprotective effects on Zucker rats. | Obesity increases oxidative stress and inflammation and thereby promotes liver damage and metabolic disorders, such as type 2 diabetes. Although exist anti-obesity treatments with employing anorexic drugs, antioxidants, and β3-adrenergic receptor (β3-ADR) agonists, their use adversely effects human health. Herein, the ... |
41871083 | Identification of polyphenols as novel neuropilin-1 cendR pocket inhibitors to block SARS-CoV-2 entry and enhance variant resistance. | Neuropilin-1 (NRP-1) functions as an essential co-receptor for SARS-CoV-2, facilitating viral entry by binding the spike protein's C-end rule (CendR) motif in its b1 domain, yet it has received less attention than ACE2 in therapeutic development. This in silico study evaluates plant-derived polyphenols as potential sel... |
41871027 | Discovery of novel murine PML isoforms. | Promyelocytic leukemia protein (PML) orchestrates the formation of PML nuclear bodies (PML NBs), membraneless organelles with diverse regulatory roles. Despite their importance, the specific functions of individual PML splicing variants remain unclear, particularly in murine models. Here we study the repertoire of muri... |
41870955 | Precise Construction of Flexible Two-Dimensional Metal-Organic Frameworks Through Pillar-Ligand Tailoring for Efficient C<sub>2</sub>H<sub>2</sub>/CO<sub>2</sub>/C<sub>2</sub>H<sub>4</sub> Separation. | The key to achieving efficient separation of C<sub>2</sub>H<sub>2</sub>/CO<sub>2</sub>/C<sub>2</sub>H<sub>4</sub> is to prepare materials with both high adsorption capacity and high selectivity. Flexible two-dimensional metal-organic frameworks (2D MOFs) exhibit excellent performance in difficult separation application... |
41870884 | Water-Mediated Isomerization in the Stepwise Hydration of the Nitrobenzene Radical Cation with 1-6 Water Molecules. | The gas-phase stepwise hydration of the nitrobenzene radical cation with 1-6 water molecules has been investigated by means of ion mobility mass spectrometry and density functional theory (DFT) calculations. The stepwise binding energies (Δ<i>H</i>°<sub><i>n</i>-1,<i>n</i></sub>) were determined by equilibrium measurem... |
41870820 | The phytohormone indole-3-acetic acid induces quorum sensing signal DSF turnover via a positive feedback biosynthetic loop in the phytopathogen Xanthomonas campestris. | Indole-3-acetic acid (IAA) accumulates in host plants following infection by Xanthomonas campestris pv. campestris (Xcc), the causal agent of cruciferous black rot. How exposure to IAA affects the invading Xcc remains unclear. Here, we demonstrate that either exogenous addition of IAA or endogenous production of IAA in... |
41870719 | Porous Functional Nanomaterials for Continuous Flow Catalysis. | With the advancement of green chemistry and process intensification, continuous flow technology has emerged as a powerful tool in the manufacturing of fine chemicals and pharmaceuticals. Owing to their highly regular porous architectures, diverse chemical compositions, and excellent catalytic activity, porous materials... |
41870635 | Virtual screening of compounds for the development of thyroid hormone analogues for potential application in cardiac regeneration. | Cardiovascular diseases remain the leading global cause of mortality, largely due to the limited regenerative capacity of adult cardiac tissue. Thyroid hormones, particularly tri-iodothyronine (T3), have been shown to stimulate cardiomyocyte proliferation through activation of the thyroid hormone receptor alpha (TRα), ... |
41870535 | Constructing Self-Adaptive Pores in a Metal-Organic Framework for Capturing CO<sub>2</sub> from Wet Flue Gas. | Efficient capture of CO<sub>2</sub> from industrial flue gas is crucial for achieving carbon neutrality. However, this goal remains a huge challenge due to the fact that the polarity and size of CO<sub>2</sub> lie between those of H<sub>2</sub>O and N<sub>2</sub>. Here, we design and synthesize a novel metal-organic fr... |
41870220 | Engineered MnO<sub>2</sub>/UiO-66-<i>x</i> Heterostructure with Tailored Interfaces for Efficient Capture of NSAIDs: Performance and Mechanistic Insights. | The widespread misuse of nonsteroidal anti-inflammatory drugs (NSAIDs) has become a growing concern due to their severe threats to aquatic ecosystems and human health. Current adsorption technologies face limitations including low capacity, poor efficiency for trace-level contaminants, and unclear removal mechanisms. T... |
41870142 | The BaeSR two-component system activates <i>bamK</i>, a paralog of the essential β-barrel foldase <i>bamA</i>, in <i>Klebsiella pneumoniae</i>. | β-Barrel outer membrane proteins (OMPs) perform critical functions in gram-negative bacteria including outer membrane biogenesis, nutrient acquisition, and efflux. OMPs are folded by the β-barrel assembly machinery (BAM) with BamA as a central and essential component. BamK, a <i>Klebsiella pneumoniae</i> BamA paralog, ... |
41870140 | Molecular-Gate Strategy for Solid-State Selective Recognition of Dioxane Isomers via Reversible Host-Guest and Charge-Transfer Modulation. | Achieving highly selective molecular recognition in the solid state remains a major challenge in supramolecular chemistry. Herein, we introduce a molecular-gate strategy that dynamically amplifies intrinsic solid-state recognition selectivity in a macrocyclic host-guest system. A perethylated leaning pillar[6]arene (Et... |
41870080 | Cyclooctatetraenyl Metal-Organic Octahedra and Their 3D Cage to 2D Nanosheet Transformations. | In biological systems, certain fundamental biomacromolecules, such as proteins and DNA, fulfill specific biological functions via structural changes triggered by stimuli. Herein, we report the synthesis of two allosteric regulation metal-organic octahedra (S1 and S2) with tailored cavities/windows. Both cages exhibit d... |
41870066 | Circular RNA circMagi1 regulates the host immune response in respiratory <i>Pseudomonas aeruginosa</i> infection through G3BP2. | <i>Pseudomonas aeruginosa</i> is a major pathogen responsible for hospital-acquired infections, and it is characterized by possessing easy colonization ability, being difficult to clear, and exhibiting pandrug resistance. After a host is infected with pathogenic bacteria, multiple molecules regulate immune defense mech... |
41870045 | Evasion of humoral immune responses by a key mutational region of the S2 subunit in PEDV variants. | Since 2010, millions of piglets have died from porcine epidemic diarrhea virus (PEDV) variant strains. Compared with classical strains, variants exhibit enhanced virulence and immune evasion capacity, rendering classical strain-based vaccines poorly effective. However, the critical mutants responsible for increased pat... |
41869945 | Bioinspired Diffusion-Limited Silicification in Coacervate Assemblies Enables Smart Nanotoroids for Deep and Sensitive Tumor Penetration. | Controlling the self-assembly of mesoporous materials beyond equilibrium remains a fundamental challenge. Conventional templating systems form ordered structures through energy-minimizing coassembly but lack the kinetic and spatial freedom required to produce asymmetric or topologically complex architectures. Here, we ... |
41869882 | pyEF: A Python Framework for QM and QM/MM Atom-Wise Electric Field Analysis. | We introduce pyEF, a software package for computing molecular electric fields, electrostatic interaction energies, and electrostatic potentials from quantum mechanical (QM) atom-centered multipole expansions with atom-wise decomposable contributions. We demonstrate the computational efficiency and accuracy of this QM-d... |
41869866 | Inhaled Angiopoietin-Like 4 Antisense Oligonucleotide Therapy for Lung Injury and Fibrosis. | Pulmonary infections and fibrosis remain difficult to treat because current interventions target isolated pathways rather than the coupled axes of inflammation, barrier integrity, and tissue remodeling. Here, it is shown that inhalationally delivered, lung-targeted antisense oligonucleotides against angiopoietin-like 4... |
41867079 | Vascularized Cardiac Tissue Engineering: From Advances in Biofabrication to Translational Applications. | The in vitro engineering of vascularized cardiac tissues holds transformative potential for disease modeling, drug screening, and regenerative therapy. However, despite rapid advances in stem cell biology, biomaterials, and biofabrication technologies, the reconstruction of functional, perfusable vasculature within eng... |
41867078 | Structurally Enhanced Colloidal Molecules via Carbene-Mediated Covalent C─H Insertion Crosslinking. | Achieving high structural stability of colloidal molecules (CMs) is crucial for their implementation in constructing functional materials and devices, but remains challenging. Here, we develop a universal strategy based on nonspecific covalent crosslinking of surface ligands for markedly enhancing the stability of CMs ... |
41866921 | Therapeutic potential of <i>Asiaticoside</i> in wound healing after endoscopic submucosal dissection (ESD). | <h4>Context</h4>Endoscopic submucosal dissection (ESD) is the standard treatment for early gastrointestinal cancers but is often complicated by delayed healing and stenosis. Current therapies like proton pump inhibitors primarily suppress acid without actively promoting mucosal regeneration. <i>Asiaticoside</i> (AS), a... |
41866915 | Inhalable gene and RNA therapy for cystic fibrosis: perspectives and progress in clinical development. | Small molecule modulators of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) play a key role in cystic fibrosis (CF) management. Around 10% of people with CF (pwCF), however, are ineligible for modulator therapy. Inhalable <i>CFTR</i> gene and RNA therapies have the potential to return normal CFTR functi... |
41866359 | Metal-organic framework-confined Co<sub>3</sub>O<sub>4</sub> for humidity-immune ozone decomposition. | Ground-level ozone (O<sub>3</sub>) is a major air pollutant, and catalytic decomposition represents a promising strategy for its removal. However, maintaining high catalytic efficiency under humid conditions remains a considerable challenge. In this study, we encapsulate ultrafine metal oxides (UMOs; e.g., Co<sub>3</su... |
41806478 | Emergence of helical structures in weakly confined, semiflexible, charged polymers. | Helical motifs are ubiquitous in macromolecular systems at the nanometer to microns length scales. At the micron length scales, the formation of helical structures can be expected to be independent of the specific molecular chemical bonds and steric interactions, and instead be driven by relatively weak intermolecular ... |
41757690 | Heteroatom doping in carbon macrocycles for advanced synthesis and applications. | Macrocycles have garnered significant research interest due to their tunable structures, unique physicochemical properties, and broad range of applications in areas such as aggregation-induced emission (AIE), molecular recognition, bioimaging, and photocatalysis. While conventional carbon-rich macrocycles depend mainly... |
41738839 | Luminescence in macrocyclic supramolecular systems. | Macrocyclic supramolecular luminescent systems play an important role in the development of supramolecular chemistry and materials science, offering a powerful alternative to conventional luminescent systems by enabling precise control over emission properties through non-covalent interactions. Macrocyclic hosts provid... |
41685519 | Molecular fluorophore dimerization: a new paradigm for precision phototheranostics. | Molecular fluorophore dimerization has recently emerged as a powerful and versatile design strategy in phototheranostics, offering a distinct regulatory regime that is fundamentally different from conventional single-molecule, polymeric, or aggregate-based systems. In this review, we present the first systematic and un... |
41636070 | Correction: Moderately polarized carborane-MOF with inverse C<sub>2</sub> selectivity for one-step polymer-grade ethylene purification. | Correction for 'Moderately polarized carborane-MOF with inverse C<sub>2</sub> selectivity for one-step polymer-grade ethylene purification' by Changhong Liu <i>et al.</i>, <i>Mater. Horiz.</i>, 2026, <b>13</b>, 473-479, https://doi.org/10.1039/D5MH01641J. |
41631371 | Charging molecular nanographenes with electrons through chemical reduction. | Chemical reduction studies of molecular nanographenes with different core dimensions and topologies are used to uncover their electron accepting abilities and original outcomes of the negative charge build-up. A combination of X-ray crystallographic and spectroscopic analysis of the gradually reduced nanographenes reve... |
41589043 | Design and engineering of biomimetic aloe vera sponges <i>via</i> recombination of functionalized peel and gel for enhanced wound healing. | Wound healing remains a complex clinical challenge due to excessive exudate accumulation, bacterial infection, sustained inflammation, and impaired tissue regeneration, highlighting the urgent need for multifunctional therapeutic dressings. Although medicinal plants such as aloe vera have long been used for skin wound ... |
41481121 | Size-dependent pyrolysis pathways of Co-triazolate MOFs tailor carbon-matrix morphology and catalytic site distribution. | The pyrolysis of metal-organic frameworks (MOFs) provides a promising route to synthesize efficient metal-N-C electrocatalysts. While most studies emphasize the metal component, here we focus on how precursor crystal size dictates the pyrolysis pathway and carbon matrix formation mechanism in Co-triazolate MOFs. By pre... |
41970859 | Melanin Building Block as Scaffold for Dynamic Submicromolar Galectin Inhibitors. | Galectins, β-galactoside-binding soluble proteins, are involved in a multitude of biological functions and several diseases, so numerous galectin inhibitors, from small molecules to multivalent glycoconjugates, have been developed and investigated as tools for therapeutic applications. Notably, multivalent ligands on a... |
41940325 | Erratum: On the derivation and electrochemical properties of calcium molybdate from zeolitic imidazole frameworks for supercapacitors. | [This corrects the article DOI: 10.1016/j.isci.2025.113397.]. |
41939932 | Resonant Raman spectroscopy elucidates pH-reversible chelation of blueberry anthocyanins with metal ions and carrageenan-enhanced photothermal stability. | Blueberry anthocyanins (BA) are commonly incorporated into foods and beverages to enhance their functionality, and the stability of BA in metal-ion-rich systems has attracted considerable attention. The structural dynamics and stability of BA-metal ion complexes were investigated using resonant Raman spectroscopy combi... |
41930323 | Antimicrobial Effect of Spices and Their Phytochemicals: A Novel Approach to Overcoming Antibiotic Resistance. | Antibiotic resistance is a significant global health challenge that demands innovative strategies to combat resistant pathogens. Spices, known for their culinary and medicinal qualities, have emerged as promising sources of antimicrobial agents due to their rich content of potent bioactive phytochemicals. Compounds suc... |
41916218 | Molecular mechanisms of interface interactions in Pickering emulsions co-stabilized by β-cyclodextrins and Tween 60. | The interface interactions in Pickering emulsions are determined by molecular interactions at the microscopic scale in essence. The interfacial properties of β-CD/Tween 60 co-stabilized emulsions were investigated experimentally and numerically. The results show that Tween 60 can increased the hydrophilicity of β-CD. T... |
41901900 | Upcycling 3D Printing PLA Waste into Functional Electrospun Membranes: Effect of Polymer Concentration on Morphology, Surface Properties and Particle Filtration Efficiency. | This study investigates the reutilization of polylactic acid (PLA) waste generated by 3D printing through its transformation into electrospun membranes with tunable morphological, surface, thermal, and filtration properties. Polymer solutions containing 5-10 wt % recycled PLA were prepared in a dichloromethane/dimethyl... |
41901901 | <i>C. albicans</i> Detection with Electrochemical Sensors by Using Molecular Imprinted Polymer Technique. | <i>Candida albicans</i> (<i>C. albicans</i>) is an opportunistic fungal pathogen and a major cause of nosocomial infections, especially in immunocompromised patients. Conventional diagnostic approaches such as blood culture and biochemical assays are accurate but require multi-step sample processing and prolonged turna... |
41900879 | Exploring Key Factors Affecting the Encapsulation Efficiency of Ligusticum Chuanxiong-Vinegar Cyperus Rotundus Essential Oil Based on QbD Principles. | <b>Objective</b>: The objective is to investigate and optimize the β-cyclodextrin inclusion process for volatile oils in Ligusticum Chuanxiong-Vinegar cyperus rotundus based on Quality by Design (QbD) principles. <b>Methods</b>: First, ligustilide and α-cyperone were selected as inclusion process indicator components u... |
41900745 | Integrating Multifunctional Hydrogen-Bonded Organic Frameworks into Intelligent Packaging: Mechanisms, Design and Challenges. | The transition from passive containment to active, responsive management is defining the next generation of intelligent packaging. This evolution creates a critical demand for materials that can be precisely engineered to monitor, regulate, and protect. Hydrogen-bonded organic frameworks (HOFs) have emerged as a unique... |
41900150 | Polyphenol-Based Nanomedicine: Versatile Platforms for Immune Modulation and Therapeutic Delivery. | Polyphenols, abundant compounds found in natural sources, exhibit various biological activities, including immunomodulatory properties that can either stimulate or suppress immune responses, making them promising for therapeutic applications. However, their poor solubility, low bioavailability, rapid metabolism, and no... |
41898738 | Constructing Curcumin-Based Biological Metal-Organic Frameworks (MOFs) for the Treatment of Alzheimer's Disease Through the Pyroptosis Pathway. | Alzheimer's disease (AD) is a chronic, progressive neurodegenerative disorder that presents as neuronal cell death caused by the pyroptosis pathway. Currently, curcumin is widely reported in the treatment of AD due to its dual inhibitory effects on NLRP3-associated inflammasome activation, but it suffers from poor bioa... |
41898727 | Terpenoid Phytosomes as Advanced Delivery Systems: Molecular Interactions, Pharmacological Potential, and Scalable Manufacturing Approaches. | Terpenoids represent a large class of bioactive natural compounds with promising pharmacological properties, including anti-inflammatory, antimicrobial, and anticancer activities. However, their clinical application is often limited by poor aqueous solubility, low membrane permeability, and suboptimal bioavailability. ... |
41895069 | Unraveling the synergistic pillar effect of dual-ion intercalation in metal-organic framework-derived vanadium oxide for ultra-stable aqueous zinc-ion storage. | Due to their high safety and affordability, aqueous zinc-ion batteries (AZIBs) have become more and more popular. But drawbacks like sluggish kinetic reactions, vanadium dissolution, and compatibility issues with zinc anodes inhibit practical implementation due to capacity decay, structural instability, and kinetic slu... |
41895043 | Tannic Acid as a Multifunctional Regulator in Calcium Phosphate Bone Biomaterials: Design Opportunities and Unresolved Challenges. | Calcium phosphate cements and related inorganic bone biomaterials are clinically constrained by coupled limitations in mechanical integrity, degradation control, and susceptibility to infection, rather than by isolated material deficiencies. Although extensive efforts have been devoted to modifying these materials usin... |
41893212 | Heparin-Based Biomaterials for Sustained Release of Growth Factors for Bone Tissue Engineering and Regeneration. | Large bone defects resulting from trauma, tumor resection, infection, or degenerative diseases pose a major clinical challenge in orthopedic surgery and regenerative medicine. Despite advances in biomaterials and surgical techniques, successful outcomes are often compromised by poor vascularization, limited osteoinduct... |
41892584 | Hyaluronic Acid-Based Gels and Biomaterial Systems for Oral Wound Healing: Design and Clinical Translation. | Hyaluronic acid (HA), a naturally occurring glycosaminoglycan and major component of the extracellular matrix, has attracted increasing interest as a therapeutic adjunct in oral wound management due to its biological activity and biocompatibility. The search for the current narrative review literature was performed in ... |
41875964 | Structure/function relationships of mitochondrial protein carrier (SLC25A20) for carnitine/acylcarnitine: A review. | The mitochondrial carnitine/acylcarnitine carrier (CAC) is a member of the mitochondrial carrier (MC) family. It facilitates the import of acylcarnitines into the mitochondrial matrix in exchange for carnitine, playing a crucial role in the carnitine shuttle, being essential for fatty acid oxidation and ATP production.... |
41866884 | Femtomolar Congener-Selective Detection of Perfluoroalkyl Substances in Water by a Cyclodextrin-Oriented Molecularly Imprinted Transistor Sensor. | Perfluoroalkyl substances (PFASs) pose significant environmental risk due to their persistence and toxicity, while the structural similarity among congeners complicates selective detection in complex matrices. This study presents a β-cyclodextrin (β-CD)-oriented molecular imprinting strategy integrated with an extended... |
41866863 | MOF-on-MOF Core-Shell Heterostructure With Synergistic Porous Interface for Highly Efficient Propane/Propylene Separation. | Propylene is one of the most important industrial chemicals, while energy-efficient separation of propylene from the propane/propylene mixtures remains challenging. Conventional metal-organic frameworks (MOFs) with tunable pore structures enable selective adsorption, yet they typically suffer from an intrinsic trade-of... |
41866858 | Emerging p-Block Metal-Based Electrocatalysts for Energy Conversion. | P-block metal-based catalysts are an emerging, effective, and sustainable alternative to precious metal electrocatalysts for energy conversion. These p-block-based materials exhibit unique characteristics, such as oxophilicity, weak hydrogen adsorption, and flexible electronic tuning, which rival those of Pt-group meta... |
41866855 | Reversible I<sub>2</sub> Uptake Induces Record-High Spin-Crossover Hysteresis in a Fe(II) Hofmann-Type MOF. | Controlling bistable spin states in Fe(II) spin-crossover (SCO) frameworks remains challenging. Here, we demonstrate that guest-induced chemical pressure provides a reversible and general strategy to amplify thermal hysteresis. In the flexible Hofmann-type MOF [Fe(pz)Pd(CN)<sub>4</sub>], vapor-phase iodine uptake produ... |
41866857 | Mechanistic Insights and Scalable Fabrication of a Ni-Based MOF Bistable Electrochromic Film Toward Energy-Efficient Displays. | Bistable electrochromic materials capable of retaining their optical states without sustained electrical power are critically important for energy-saving technologies. Unfortunately, metal-organic frameworks (MOFs) have remained largely underexplored for such applications, primarily due to the poor stability of radical... |
41866831 | Adaptive Pore Deformation in Metal-Organic Framework Nanosheets for Enhanced Enzymatic Catalysis. | The nanoconfinement of enzymes within porous scaffolds is a pivotal strategy for constructing robust and industrially relevant biocatalysts. However, a molecular-level understanding of the host-guest interactions that dictate catalytic efficiency remains a significant challenge, largely due to the inherent heterogeneit... |
41866822 | Two-Color Digital Immunoassay for Simultaneous Detection of Low-Abundance Neurodegenerative Disease Protein Biomarkers. | We developed a novel two-color digital immunoassay platform for the simultaneous detection of neurodegenerative disease protein biomarkers (neurofilament light chain (NfL) and interleukin-6 (IL-6)) in a homogeneous, wash-free format. This multiplex approach employs two antibody pairs: capture antibodies conjugated with... |
41866783 | A century of vitamin E research: The innovative journey from basic biology to synthetic bio-manufacturing. | Since its discovery in 1922, vitamin E research has evolved from the search for a mysterious "reproductive factor" to the exploration of a diverse family of bioactive molecules central to plant physiology and human health. This review traces a century of progress, highlighting advances in our understanding of vitamin E... |
41866762 | Broadband Reflective Cholesteric Liquid Crystals for Low-Blue Circularly Polarized Light Generation in the Visible Region. | In this work, a polymerizable chiral liquid-crystal monomer was first synthesized from inexpensive biomass-derived cholesterol through a simple transformation. Co-assembling this chiral monomer with a polymerizable achiral liquid-crystal monomer and followed by initiator-free photopolymerization, yielded a cholesteric ... |
41866702 | Inorganic Node-Tuned Reticular Diversification of Metal-Organic Frameworks: Dual-Site Functionalization for Enhanced Methane Separation. | Reticular chemistry offers a targeted and streamlined approach to synthesizing metal-organic frameworks (MOFs) through the assembly of predesigned molecular units. In this study, we investigated inorganic node-directed reticular diversification of MOFs by employing a nitrogen-containing aromatic polycarboxylate ligand ... |
41866234 | Recent advances in hierarchically porous metal-organic frameworks mediated enzyme immobilization: progress and perspective. | Enzymes are essential catalysts in numerous biological processes due to their efficiency, specificity, and selectivity. To enhance their stability and reusability, enzyme immobilization onto solid supports is crucial. Hierarchically porous metal-organic frameworks (HP-MOFs), with tunable meso- and macropores, have emer... |
41865386 | Photoresponsive Metallo-Supramolecular Systems Constructed From a Bidentate Ligand. | Metallosupramolecular polymers (MSPs) are stimuli-responsive materials whose properties can be tailored through the choice of ligand and metal salt. Their dynamic behavior is governed by the reversibility of the metal-ligand (ML) complexes and the ability to shift the equilibrium between assembled and disassembled stat... |
41865384 | Mini Review on Helical Polymers for Disease Treatment and Tissue Repair. | Helical structures such as DNA and proteins are indispensable in organism. As a distinctive structural configuration, helical structures hold extensive application potential across multiple fields. So, the research of helical macromolecules can help to deeply understand life phenomena and develop new materials for biom... |
41965297 | Topology-engineered dopamine-mediated flower-like gold nanoparticle adjuvants: Boosting immune responses and enabling sensitive immunoassays for albendazole residue detection. | <h4>Background</h4>Albendazole (ABZ) exhibited teratogenic and embryotoxic effects in diverse animal species, implying comparable risks to humans; residues derived from improper veterinary use can enter the food chain via transfer, ultimately endangering human health. To obtain efficient anti-albendazole (ABZ) monoclon... |
41965292 | Amino acid-based anionic surfactant as a novel amphiphile for sustainable green supramolecular solvent formation in liquid-phase microextraction: determination of penicillins in bovine milk. | <h4>Background</h4>The selection of an eco-friendly, selective and cheap extraction solvent for effective and green liquid-phase microextraction is always a challenging task in analytical chemistry. Supramolecular solvents serving as safer alternatives to traditional extractants hold promise for this goal. Additionally... |
41953277 | Targeting sweet taste receptor T1R2/T1R3: a new strategy for metabolic disease regulation and intervention of multiple organ diseases. | The overconsumption of dietary sugars poses significant health risks, creating a conflict with the innate human preference for sweet taste. Beyond its role in taste perception on the tongue, the sweet taste receptor (STR, a heterodimer of T1R2/T1R3) serves as a crucial nutrient sensor in metabolic organs, including the... |
41937950 | Tuneable electronic coupling in linked bis(cubane) cobalt-oxo clusters. | A family of cobalt-oxo bis(cubane) complexes wherein each subunit is derived from the Co<sub>4</sub>O<sub>4</sub> cubane, a known water oxidation catalyst, was synthesized. Both 4,4'-bipyrdine and pyrazine were demonstrated to serve as viable bridging ligands. Through an analysis of their half-wave splitting potentials... |
41901897 | Polymer-Embedded Deep Eutectic Solvents: Mechanistic Insights into Storage and Supersaturation Stabilization. | Poor aqueous solubility remains a major limitation for the oral delivery of many active pharmaceutical ingredients (APIs). Deep eutectic solvents (DESs) exhibit remarkable drug-solubilization capacity, yet rapid precipitation upon aqueous dilution can compromise their ability to sustain supersaturation. This study inve... |
41900876 | Biofabrication of <i>Leucas aspera</i>-Mediated Chitosan-Zinc Oxide Nanocomposites for In Vitro Antioxidant, Antibacterial, Anti-Inflammatory and Wound-Healing Properties. | <b>Background/Objectives</b>: Nanostructured biomaterials based on natural polymers have gained increasing attention in pharmaceutics due to their biocompatibility, multifunctionality, and diverse biomedical applications. This novel study aimed to biofabricate chitosan-doped zinc oxide nanocomposites (CS-ZnONCs) using ... |
41900875 | Differentiating Resistance from Formulation Failure: Isoniazid Instability and Poor Dissolution in Crushed Multi-Drug Paediatric Preparations. | <b>Background:</b> Bedside manipulation of adult anti-tuberculosis tablets for paediatric dosing is common in low-resource settings, yet it can compromise drug stability. This study investigated how grinding and multi-drug co-suspension affect the supramolecular organisation, thermal stability, and dissolution of isoni... |
41900270 | A Composite Structure of Modified Silver Nanoparticles for Improving the Recognition Performance of Electrode. | To meet the demand for rapid detection of methylene blue residues in aquatic products, this study constructed a composite structure modified with silver nanoparticles on the surface of a glassy carbon sheet for precise detection. This composite film used the synergistic effect of the composite structure, which signific... |
41900146 | Tuning Supramolecular Structure in Trimethylglycine Cocrystals: Competition Between Hydrogen and Halogen Bonding upon Cl/Br Substitution. | Two novel cocrystals of zwitterionic trimethylglycine (TMG) with 2,6-dichlorophenol [TMG•2,6-dichlorophenol] (1:1) and 2,6-dibromophenol [TMG•2,6-dibromophenol] (1:2) are synthesized and structurally characterized using single crystal X-ray diffraction. To estimate the energy of various intermolecular interactions, per... |
41899484 | <i>Eupatorium lindleyanum</i> DC. Suppresses Cytokine Storm by Inhibiting NF-κB and PI3K-Akt Signaling in Sepsis-Associated and Virus-Related Acute Lung Injury. | Cytokine storm is a central pathogenic mechanism underlying sepsis-induced acute lung injury (SALI) and severe coronavirus disease 2019 (COVID-19), yet effective therapeutic strategies remain limited. <i>Eupatorium lindleyanum</i> DC. (EL), a traditional Chinese medicinal herb, has been reported to possess anti-inflamm... |
41897542 | Beyond Sensory Properties: Molecular Interactions of Antioxidant Flavour-Active Polyphenols Across the Food-Oral-Gut Axis. | Dietary antioxidants are widely valued for their potential health benefits, but incorporating them into functional foods is not straightforward. Polyphenols are among the most abundant and important antioxidants in foods, and this review focuses on them because the same structural features linked to their health-promot... |
41897407 | The Role of Cholesterol at the CHOL2 Site and the Dimeric Interface in the Regulation of Serotonin Transporter Function and Dimerization. | Serotonin transporter (SERT) precisely regulates serotonin (5-HT) signaling in the central nervous system and is a major target of antidepressants for the treatment of major depressive disorder. Despite significant progress in characterizing its structure and transport mechanism, the regulation of SERT function by vari... |
41893715 | Canine Cognitive Dysfunction and Alzheimer's Disease: Pathophysiological Relationships and the Impact of Glymphatic System Impairment on Neurodegeneration. | Canine cognitive dysfunction (CCD) is a common age-related neurodegenerative disorder in dogs that shares several pathological and clinical features with human Alzheimer's disease (AD). In both species, β-amyloid (Aβ) accumulates within the brain parenchyma and cerebral vessel walls and is associated with synaptic loss... |
41893253 | A Facile Nanocarrier for Paclitaxel Delivery Based on Carboxymethyl Chitosan Encapsulated 6-Deoxy-6-Mercapto-β-Cyclodextrin Grafted Concave Cubic Gold. | Paclitaxel is a first-line anticancer drug, but its low water solubility impedes bioavailability. The purpose of this study is to estalish a delivery strategy via carboxymethyl chitosan (CMCS)-encapsulated 6-deoxy-6-mercapto-β-cyclodextrins (dmβCDs)-modified concave cubic gold (CCGs) to achieve PTX release. CCGs were i... |
41893251 | CaCO<sub>3</sub>/BiO<sub>2-x</sub>/CdS Composite with Rapid Photocatalytic Reduction of Cr(VI) Under Visible Light. | CaCO<sub>3</sub>/BiO<sub>2-x</sub>/CdS (CCO/BO/CS) ternary composite photocatalyst was synthesized via a hydrothermal method combined with chemical precipitation, and its performance in the photocatalytic reduction of hexavalent chromium (Cr(VI)) under visible light was systematically investigated. Compared with pure B... |
41892977 | Biophysical Characterization of a Carotenoprotein from Marine Sponge <i>Tedania ignis</i> Reveals Pigment-Dependent Stability and Antibiotic Interactions. | Carotenoproteins from marine sponges represent an underexplored class of pigment-protein complexes with distinctive structural and functional properties. Here, we report the isolation and biophysical characterization of a blue carotenoprotein from the sponge <i>Tedania ignis</i>, termed Ti-CP. The protein was purified ... |
41892583 | Formulation and 3D Printing of Collagen/Chitosan Inks: Tailoring the Scaffold Properties. | The development of inks with suitable rheological, physicochemical, mechanical, and biological properties is crucial for the successful fabrication of functional scaffolds via extrusion-based 3D printing. In this study, collagen/chitosan hydrogels with varying polymer ratios were developed and characterized to evaluate... |
41892265 | Transcriptome Analysis and Identification of Chemosensory Genes in <i>Leguminivora glycinivorella</i>. | The soybean pod borer, <i>Leguminivora glycinivorella</i>, is a monophagous pest that threatens soybean production. Its larvae feed concealed within pods, which limits the efficacy of conventional insecticides. Elucidating its chemosensory system is therefore essential for developing green, behavior-based management st... |
41892068 | Molecularly Imprinted Polymers as Biomimetic Test Zones in Paper-Based Nucleic Acid Assays-Comparing Vertical and Lateral Flow Formats. | The development of rapid and sensitive point-of-care nucleic acid tests benefits from robust synthetic recognition elements. Here, a biotin-specific molecularly imprinted polymer (MIP) was synthesized using an optimized protocol and integrated as a biomimetic test zone into two paper-based formats: nucleic acid vertica... |
41890656 | Theranostic Potentials of Metallic Nanoparticles in Thyroid Diseases: Challenges and Prospects. | Thyroid disorders, encompassing benign nodules, goiter, hyperthyroidism, hypothyroidism, and malignancies, present significant clinical challenges due to limitations in conventional diagnostic and therapeutic modalities. Metallic nanoparticles, particularly gold and iron-oxide-based systems, have emerged as promising t... |
41880965 | In-situ grown dual lanthanide metal-organic framework electrospinning nanofiber film for the ratiometric fluorescent sensing of glyphosate in foods. | The extensive utilization of glyphosate (Gly) leads to food contamination that poses the potential threat to human health. Therefore, it is urgent need to develop high-sensitivity methods for Gly detection. Herein, a dual-lanthanide metal-organic framework (Ln-MOF) integrating electrospinning nanofiber membrane was fab... |
41880911 | Boric acid functionalized spherical covalent organic frameworks as an online extraction adsorbent for the selective enrichment of trace nucleosides from biological samples. | In this work, a novel spherical boronic acid-functionalized covalent organic framework (COF) was designed and synthesized via a facile two-step strategy. This approach involved the construction of a vinyl-functionalized COF (TpbDva), followed by the covalent grafting of 4-mercaptophenylboronic acid through a thiol-ene ... |
41871781 | A resveratrol dimer nanoagent boosts sonodynamic-immunotherapy via suprathreshold autophagy. | Suprathreshold autophagy (SA)-induced immunogenic cell death (ICD) has emerged as a promising strategy in cancer immunotherapy. The reactive oxygen species (ROS) storm from sonodynamic therapy (SDT) has garnered significant attention due to its potential to enhance autophagy. However, the ability to modulate autophagy ... |
41865126 | Recent Advances in the Non-viral Delivery of Genes to Central Nervous System Disorders. | Disorders of the central nervous system (CNS), neurological disorders, neurodegenerative disorders, genetic disorders) constitute a significant burden on global health, and current treatment options remain challenging. As treatment for CNS disorders is primarily palliative, the underlying causes of disease progression ... |
41865051 | Identification of a novel monoclonal antibody derived from the lumpy skin disease virus ORF123 that confers cross-binding and cross-neutralizing activity against Capripoxvirus members. | Capripoxviruses cause diseases (e.g., lumpy skin disease, sheep pox, and goat pox) that significantly hinder the growth of livestock production in endemic areas. Here, we systemically describe a B-cell monoclonal antibody (mAb) derived from the lumpy skin disease virus (LSDV) ORF123, which exhibits cross-reactivity wit... |
41865045 | Smallest acyclic tricationic molecule containing a Bis(phosphine)-stabilized low-valent triantimony-based Unit. | Element-element bonded multiply charged cationic species are well known as dimers or small cyclic oligomers in the condensed phase. However, the smallest acyclic version, a trinuclear unit possessing greater than a monocationic charge, has remained elusive. Here we introduce a bis(phosphine) supported low valent triant... |
41864982 | Disrupting the ASH2L-DPY30 PPI in cancer: structure, function, and therapeutic opportunities in H3K4 methylation. | The ASH2L-DPY30 interaction is a structurally conserved and functionally essential component of the COMPASS family of histone methyltransferases responsible for H3K4 trimethylation. This minimalist helix-groove interface plays a critical allosteric role in stabilizing ASH2L, aligning the catalytic SET domain on nucleos... |
41863727 | Osteoporosis treatment indications following fracture: identifying relevant fracture sites for Fracture Liaison Services. | Osteoporotic fractures are associated with morbidity, mortality and high healthcare costs. Fracture Liaison Services (FLS) prevent subsequent osteoporotic fractures but are traditionally limited to include major osteoporotic fractures (MOF). When the FLS at Skaraborg Hospital in Skövde, Sweden included both MOF and non... |
41863413 | Functional Metal Complexes for Solar-Light-Driven Energy Conversion. | Solar energy conversion offers the advantage of being more environmentally friendly compared to the use of nuclear or fossil fuels. In recent years, metal complexes as functional materials have received extensive attention, and great progress has been made in energy storage and conversion. They usually possess tunable ... |
42006285 | Liquid-liquid phase separation in cancer therapy resistance. | Liquid-liquid phase separation (LLPS) has emerged as a fundamental mechanism that orchestrates essential cellular functions. Emerging evidence has established a compelling link between LLPS and core oncogenic processes, including cancer initiation, metastasis, immune evasion, and therapeutic resistance. Among these pro... |
41970926 | Retraction of "Heteroatom (B, N, P, and S)-Doped Cyclodextrin as a Hydroxyurea (HU) Drug Nanocarrier: A Computational Approach". | [This retracts the article DOI: 10.1021/acsomega.2c06630.]. |
41970848 | PEGylated Flower-Like ZnO Microspheres: Reducing Nonspecific Adsorption and Promoting a High Capacity for Separation of Bovine Hemoglobin. | High adsorption capacity and excellent selectivity are two crucial criteria for solid-phase extraction adsorbents to be effectively applied in the separation and purification of proteins. Herein, a novel flower-like microsphere structure grafted with poly-(ethylene glycol) diamine (NH<sub>2</sub>-PEG-NH<sub>2</sub>) we... |
41970822 | Novel Palmitoyl Pentapeptides: Self-Assembly, Collagen Stimulation, Antioxidant Activity, and Influence of Skin Microbiota Health. | New lipopeptide analogues of C<sub>16</sub>-KTTKS, containing tyrosine (C<sub>16</sub>-KTTKY) and glutamic acid (C<sub>16</sub>-KTTKE) residues, were characterized by physicochemical and biological assays to understand their collagen stimulation and ability to control skin commensal microorganism growth. The presence o... |
41965300 | Development and validation of a Mn/MOF-808 based colorimetric platform for rapid and reliable on-site monitoring of iodide in marine environments. | <h4>Background</h4>Iodide (I<sup>-</sup>) serves as a key indicator for monitoring <sup>131</sup>I contamination in marine environments. However, rapid on-site detection remains challenging due to the short half-life of radionuclides and the complex nature of seawater. Traditional nanocatalysts exhibit limited catalyti... |
41955976 | The conservative mixing behavior of dissolved organic matter: Assessment of size distributions and optical properties. | Dissolved organic matter (DOM) is ubiquitous and influences pollutant transport, photochemistry, and water treatment. As a heterogeneous mixture, current theories suggest that DOM forms supramolecular assemblies; yet, common statistical methods assume the principles of additivity and conservative mixing. This study eva... |
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