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41953723 | Targeted antibacterial and mesenchymal stem cell-modulatory hydrogel for periodontitis treatment. | Mechanical debridement and systemic antibiotics, as current therapeutic modalities for periodontitis, suffer from limitations, including insufficient local efficacy and bacterial resistance. Herein, a dual-mode injectable hydrogel (A-CC-PBA@ZIF-8@CAPE Gel) has been designed and prepared for enhancing the therapeutic ef... |
41953720 | Cholesterol analogs modulate lipid nanoparticle performance for mRNA delivery after lyophilization and enable ocular disease therapy. | Lipid nanoparticles (LNPs) are essential nucleic acid delivery carriers, with cholesterol being crucial for their structural integrity and intracellular transport. Although C24-alkyl phytosterols (cholesterol analogs) promote gene transfection in HeLa cells, their broader impact on mRNA-LNP performance across organs an... |
41953584 | Anthracene-Modified Nanoporous Silica Nanoparticles for ATP Detection and Salivary Diagnostics in Parkinson's Disease. | ATP is an essential biological molecule, and abnormal levels are linked to various diseases. In this study, we developed an optical sensor array consisting of an anthracene-modified MCM-41 mesoporous nanoparticle-based hybrid organic-inorganic material to detect ATP in a TRIS-HCl buffer (pH 7). To create the sensor, we... |
41952673 | A drug-drug co-amorphous formulation for enhanced solubility and transdermal absorption of rotundine. | The limited aqueous solubility and transdermal permeability of rotundine (RTD) constrain its therapeutic utility in pain management. To address these challenges, a co-amorphous formulation incorporating RTD and syringic acid (SA) were designed to improve solubility, dermal permeation, and pharmacological efficacy. The ... |
41950753 | Immune protection in chickens via lipid nanoparticle-encapsulated VP2 DNA vaccine against very virulent infectious bursal disease virus. | Infectious bursal disease (IBD), caused by infectious bursal disease virus (IBDV), is an acute and highly contagious avian infection that primarily causes severe immunosuppression in chickens. Since the 1980s, very virulent IBDV (vvIBDV) has triggered a global crisis in the poultry industry due to its high mortality. A... |
41948008 | Toxicity of nanostructures in drug delivery applications. | Nanostructures and nanoparticles have transformed drug delivery by enabling enhanced bioavailability, targeted therapy, controlled drug release, and improved therapeutic outcomes; however, these benefits come with complex safety and translational challenges that remain incompletely resolved. This updated review synthes... |
41939916 | Methodology for a freshly engineered or cryo-preserved 3D tuberculoma bioplatform for studying tuberculosis biology and high-content screening of therapeutics. | Tuberculomas are the conglomeration of tuberculous granulomas into structurally organized three-dimensional (3D) masses that result from <i>Mycobacterium tuberculosis</i> infection and represent one of the more severe morphological forms of tuberculosis (TB). Several <i>in vitro</i> models that mimic human TB granuloma... |
41939898 | A multi-epitope approach for development of a universal vaccine against leptospirosis. | <h4>Introduction</h4><i>Leptospira</i>, a zoonotic pathogen, poses a significant public health threat, causing morbidity and mortality in both humans and animals. Although several bacterin and recombinant vaccines targeting specific serovars have been developed, most provide short-term, serovar-restricted protection an... |
41939904 | Hepatitis C virus E1 protein-specific linear B-cell epitopes, pan-genotype reactivity, and functional relevance. | <h4>Background</h4>Hepatitis C virus (HCV) infection poses a major global risk for chronic liver disease, underscoring the critical need for prevention. Our previous studies demonstrated that HCV-modified soluble E1/E2<sub>F442NYT</sub> envelope glycoproteins delivered from an mRNA-lipid nanoparticle (LNP) vaccine plat... |
41939890 | GPX2+ tumor cells recruit LGALS1+ B cells via CCL26-CCR3 axis to promote immunosuppression and tumor progression in hepatocellular carcinoma. | The molecular link between Hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC) progression remains elusive. Here, we identify glutathione peroxidase 2 (GPX2) as a pivotal mediator of this process. Single-cell analysis of HBV-positive HCC reveals a distinct GPX2<sup>+</sup> CSC population characterized ... |
41939861 | Immunomodulation by glycosylation: bridging glycobiology to adaptive immunity and therapeutic innovation. | Adaptive immunity provides specific and long-lasting protection through antigen-specific responses and immune memory, a property that has been successfully harnessed in transformative immunotherapies. Advancing these treatments requires a deeper understanding of the molecular mechanisms that fine-tune immune activity. ... |
41939862 | Peptide hydrogel boosts the cytotoxic and metabolic fitness of Vγ9Vδ2 T cells in melanoma immunotherapy. | <h4>Background</h4>Adoptive cell therapy with Vγ9Vδ2 T cells represents a promising approach for melanoma treatment. However, its efficacy is often limited by poor persistence, inadequate tumor infiltration, and functional suppression within the tumor microenvironment. Peptide-based hydrogel as a vehicle has exhibited ... |
41939723 | Oral delivery of peptides and proteins: pharmacokinetic boundaries, negative selection, and route triage. | Oral delivery of peptides and proteins has been pursued for over a century due to its noninvasive nature. Despite sustained innovation across multiple technological generations-such as enteric coatings, enzyme inhibitors, permeation enhancers, nanoparticles, and ingestible devices-most oral peptide programs have failed... |
41939482 | Recent advances in drug repurposing for cancer immunomodulation emerging strategies, mechanistic insights, and clinical translation. | Drug repurposing is a significant strategy in drug discovery, as it saves substantial amounts of time and money. Drugs already approved for other diseases can be repurposed to target cancer. Cancer remains one of the most fatal diseases, and it still does not have a cure. Developing new drug molecules and advancing the... |
41939442 | Metastable phase diagram, mobility, and kinetic stability of amorphous mixtures of two mutually compatible APIs. | DSC, dielectric spectroscopy, and optical microscopy, are employed to analyze the equilibrium and out-of-equilibrium binary phase diagram of two antifungal azole compounds, fluconazole (FLZ) and econazole (ECZ), to study the physical stability of co-amorphous formulations that may allow co-administration and a faster d... |
41939440 | Hesperidin-loaded Eudragit S100 nanoparticles alleviate ulcerative colitis by repairing intestinal barrier and modulating gut microbiota. | Ulcerative colitis (UC) is a chronic inflammatory bowel disease with no curative therapy. Hesperidin (HDN) exhibits potent anti-inflammatory and antioxidant properties, but its poor solubility limits its therapeutic application. Here, we developed a colon-targeted nano-formulation by encapsulating HDN in pH-responsive ... |
41939185 | Thymol: properties, synthesis, mechanism of action, and applications. | Thyme (<i>Thymus vulgaris</i>) has long been valued as both a culinary herb and a medicinal plant. Among its constituents, thymol-a key monoterpenic phenolic compound-exhibits a wide range of biological activities, including antimicrobial, antioxidant, anti-inflammatory, and insecticidal properties, which endow it with... |
41939139 | A universal "Divide-and-conquer, precise reconstruction" strategy: Multiscale simulation-guided high-fidelity restoration and controlled release of rose aroma. | The high-fidelity encapsulation and controlled release of natural aromas remain significant challenges in flavor science due to the compositional complexity of essential oils and heterogeneous host-guest interactions in conventional co-inclusion systems. Using rose aroma as a representative model, this study presents a... |
41938701 | Stabilizing effects of geraniol on native and pathogenic M39R rhodopsin variants. | <h4>Introduction</h4>Mutations in rhodopsin are a major cause of autosomal dominant retinitis pigmentosa, frequently due to protein misfolding and reduced structural stability. The M39<sup>1.34</sup>R variant, located in transmembrane helix 1, is associated with sector retinitis pigmentosa and exhibits pronounced therm... |
41938067 | Protein lactylation in Alzheimer's disease: bridging metabolism, pathology, and therapeutic opportunity. | Lactate, long regarded as a mere by-product of glycolysis, is increasingly recognized as a signaling metabolite and epigenetic regulator through protein lactylation. This lysine-specific post-translational modification functionally couples cellular metabolic states to gene regulatory programs and orchestrates cell type... |
41938016 | Recent advances in m6A RNA modification in hepatocellular carcinoma: from mechanisms to therapeutic potential. | Hepatocellular carcinoma (HCC) remains a major global health burden due to its high incidence and mortality, underscoring the urgent need to elucidate the molecular mechanisms of HCC and to improve diagnosis and therapeutic approaches. As the most prevalent form of mRNA modification, N6-methyladenosine (m6A) plays a ce... |
41909502 | Intelligent-responsive hydrogel synergistically mediates immune remodel-antibacterial-angiogenesis cascade for diabetic foot ulcer repair. | The healing of diabetic foot ulcers (DFU) is severely hindered by dysregulated immune microenvironment, recurrent infections, and insufficient angiogenesis. The persistent and resistant nature, coupled with elevated morbidity and amputation rates, has driven the scientific community to pursue the development of novel t... |
41901172 | Intestinal Multi-Target Mechanisms of Natural Active Substances in Hyperuricemia Alleviation: Recent Progress. | Hyperuricemia, a common metabolic disorder characterized by elevated serum uric acid (UA) levels, can lead to severe complications such as gout and renal impairment. Conventional therapies, while effective, are frequently accompanied by significant adverse effects, underscoring the urgent need for safer therapeutic alt... |
41900725 | Anode-Less (Anode-Free) Batteries: From Fundamental Principles to Practical Pathways Toward Solid-State Implementation. | Anode-less battery architectures, which eliminate the host anode material, have attracted considerable attention as a promising approach to increase energy density, simplify cell manufacturing, and improve safety in next-generation energy storage systems. This review provides a structured and integrative overview on th... |
41900716 | Harnessing Poly(9,9-dialkylfluorene-alt-benzothiadiazole) for Circularly Polarized Electroluminescence: Advances and Perspectives. | Circularly polarized (CP) organic light-emitting diodes (CP-OLEDs) have attracted considerable attention due to their promising applications in next-generation display systems, optical data transmission, and quantum computing, and their potential roles in medical devices. Achieving efficient and tunable CP emission rem... |
41900143 | The Difluoroboranyl-Fluoroquinolone Derivative "7a" Inhibits Bacterial DNA Gyrase and Exhibits Potent Activity Against Ciprofloxacin-Resistant <i>S. aureus</i> In Vitro and In Vivo Using an Acute Pneumonia Model. | According to the World Health Organization, antibiotic research remains insufficient, emphasizing the urgent need for new active molecules, particularly against resistant bacteria. Based on known antibacterial scaffolds, new fluoroquinolone derivatives have been synthesized by our research group, including compound <b>... |
41899894 | Lab-on-a-Chip and Microfluidics Technologies for Nano Drug Delivery. | Lab-on-a-Chip (LoC) and microfluidic technologies are rapidly reshaping the development pipeline for nano drug delivery systems (DDSs) by enabling precise control of physicochemical properties, high-throughput screening, and integrated biological evaluation within miniaturized platforms. This review synthesizes recent ... |
41898705 | Dihydroquercetin in Obesity and Prediabetes: Case Report and Insights from Molecular Modeling. | Dihydroquercetin (DHQ) is a promising object for the development of a treatment for patients with obesity and prediabetes requiring a moderate therapeutic effect. This paper reports a clinical case of DHQ application in a 30-year-old Caucasian male and proposes a molecular mechanism of its anti-obesity effect. DHQ was ... |
41898682 | Special Issue "Metal-Organic Coordination Compounds: Synthesis, Structure, Spectra, Applications". | Compounds of metals with organic moieties cover the widest classes of chemical substances, with various applications in the chemical industry, catalysis, microelectronics, sensors, medicine, pharmacology, etc [...]. |
41898679 | Special Issue "Functional Nanomaterials: Structures, Compositions and Various Applications". | Research into functional nanomaterials lies at the heart of many technological breakthroughs because it connects fundamental structure-property relationships with real-world performance in devices and processes [...]. |
41898667 | Advanced Research on LysM Domain-Containing Proteins: Functional Mechanisms and Roles in Pathogenicity of Plant Fungi. | Lysin motif (LysM) domain-containing proteins are widespread in prokaryotes and eukaryotes, and play crucial roles in microbe-host interactions. In recent decades, a large number of LysM domain-containing proteins have been identified and confirmed to participate in various biological processes, including microbial gro... |
41897957 | Oxidative Stress and Ultrastructural Changes in Laminar Tissue of Dairy Cows with Acute Laminitis Induced by Oligofructose Overload. | This study explored ultrastructural changes and the expression of oxidative stress-related genes and proteins in the laminar tissue of dairy cows with acute laminitis induced by oligofructose (OF) overload. Twelve clinically healthy, non-pregnant Chinese Holstein cows were randomly allocated into two groups: the OF-ove... |
41897815 | Preparation and Identification of Corn-Derived Bioactive Peptides with Triple Efficacy of ADH-Activating, XOD-Inhibiting and Antioxidant Activity. | The health risks associated with excessive alcohol consumption have emerged as a public health challenge, with alcohol-associated liver disease (ALD) and hyperuricemia (HUA) being particularly prominent health issues. Current treatments often have side effects, driving the need for safe, multi-target natural alternativ... |
41897537 | L-Selenomethionine Alleviates Cryo-Induced Ferroptosis Through the NRF2-SLC7A11-GPX4 Pathway, Improving Post-Thaw In Vitro Quality of Dairy Goat Spermatozoa. | <h4>Background</h4>Cryopreservation induces oxidative stress, membrane disruption, and mitochondrial injury in spermatozoa, leading to impaired motility and fertility. Selenium, as an essential trace element, protects cells from oxidative damage through selenoproteins such as glutathione peroxidase 4 (GPX4), a critical... |
41897405 | Oxidative Stress in Diabetic Cardiomyopathy: Molecular Mechanisms and Emerging Therapeutic Targets. | Diabetic cardiomyopathy (DCM) is a distinct myocardial disorder that develops independently of coronary artery disease and hypertension and represents a major contributor to heart failure in patients with diabetes. Beyond hemodynamic alterations, DCM is driven by complex molecular mechanisms involving metabolic dysregu... |
41892975 | Marine Bioactive Compounds from Functional Seafoods: Pharmacological Mechanisms and Health Applications. | Functional seafoods derived from marine organisms, including fish, shellfish and algae, are gaining increasing attention due to their high content of bioactive compounds, such as omega-3 fatty acids, peptides, polysaccharides and antioxidants, which provide health benefits beyond basic nutrition. These marine-derived c... |
41892580 | Cell-Laden Gel Biomimetic Skin Promotes Full-Thickness Skin Wound Regeneration. | The regeneration and repair of scarless skin tissue remain a significant challenge for full-thickness wounds. Traditional wound management approaches, particularly passive healing through scabbing and conventional mechanical debridement, are frequently associated with significant pain, high infection risks, and abnorma... |
41892480 | Mechanisms of Bacterial Resistance and Innovative Strategies to Overcome Antimicrobial Resistance. | Widespread, sometimes careless use of antibiotics has accelerated the rise and spread of antibiotic-resistant pathogens. These resistant bacteria are now often found in animal-based foods like meat, milk, and eggs, as well as in plant-based foods such as fruits and vegetables. Contaminated food is a key way these bacte... |
41892065 | Microfluidic-Based Whole-Cell Biosensor Systems-Challenges and Future Applications. | The integration of whole-cell biosensors in miniaturized measuring devices to exploit synergetic effects as small, rapid, cost-effective, sensitive, and highly specific platforms with point-of-care applicability was often discussed in recent years and many different setups have been presented to date. In many cases the... |
41890435 | Investigations into linker effects of DNA-VHL ligand conjugates by multiplexed affinity measurements using focal molography. | The determination of kinetic binding properties of DNA-tagged compounds binding to a target protein is an important step in the development of nucleic acid-based PROTACs. Focal molography (FM) is a recent addition to the toolbox of instruments that allow for measuring kinetic binding data of drugs binding to a target p... |
41889448 | Bifunctional polymer assisted growth of crack-free thick perovskite films for flexible X-ray detection. | The expanding use of perovskite materials in flexible optoelectronics has sparked growing interest in their application for flexible X-ray detectors. Achieving thick perovskite films is crucial for effective X-ray absorption; however, such films typically exhibit brittleness and crack formation. In this work, we presen... |
41884485 | Biopolymer Hydrogel-Based Nanocomposites Functionalized with Natural Products for Wound Dressings: Translational Advances in Drug Design, Development, and Therapeutic Wound Care. | Biopolymer hydrogel-based nanocomposites functionalized with natural products have emerged as advanced therapeutic platforms for next-generation wound dressings, addressing the multifactorial challenges associated with acute and chronic wounds. By integrating biocompatible hydrogel scaffolds with natural product-derive... |
41884284 | Tumor Microenvironment-Responsive Nanomedicine: Monitoring and Modulating the Tumor Microenvironment for Precision Cancer Therapy. | The tumor microenvironment (TME) is a dynamic and heterogeneous ecosystem whose abnormal vasculature, dense extracellular matrix, metabolic reprogramming and immunosuppression collectively hinder drug penetration, drive therapeutic resistance and limit responses to immunotherapy. TME-responsive nanomedicine provides an... |
41884275 | Intraperitoneal Co-Delivery of Claudin18.2×41BB and EpCAM×CD3 Bispecific Antibodies via mRNA-LNPs Synergistically Suppresses Gastric Cancer Peritoneal Metastasis Through T Cell Co-Activation. | <h4>Introductions</h4>Gastric cancer with peritoneal metastasis (GCPM) carries a poor prognosis, constrained by inadequate drug delivery, systemic toxicity, and an immunosuppressive microenvironment. We developed E3C4, a single mRNA-lipid nanoparticle (LNP) co-encoding EpCAM×CD3 and Claudin18.2×41BB bispecific antibodi... |
41884276 | Radiolabeled Iron-Based Nanomaterials for Cancer Diagnosis and Therapy. | Cancer remains one of the leading causes of death worldwide, with diagnosis and treatment continuing to pose significant challenges. In recent years, iron-based nanomaterials (iron oxide-based nanomaterials, iron-based complex conjugates) have garnered unprecedented attention due to their excellent functionality, super... |
41880913 | Trinity synergy of guanidine-functionalized polymer brush-modified β-cyclodextrin polymer magnetic beads for recognition of phosphopeptides in serum of Alzheimer's disease. | Systematic profiling of protein phosphorylation is pivotal for elucidating the molecular pathogenesis of Alzheimer's disease (AD). Here, we report the rational design of magCEP@PEI@G, a multifunctional magnetic adsorbent integrating β-cyclodextrin-epichlorohydrin polymers, polyethyleneimine (PEI), and guanidino funct... |
41880735 | Ultrasensitive biosensing platform via self-catalytic-induced luminescence amplification and bifunctional biopeptides for immunoassay. | The output signal of the sensor is closely correlated with its detection sensitivity, while the selection of luminescent materials and the presence of interfering substances in the detection medium can both affect the output signal. In this study, a bifunctional peptide (HWRGWVDEDKDKDKC) with antibody targeted fixation... |
41875778 | Deep learning-assisted Ce/Zr-MOF nanozyme hydrogel sensor for colorimetric/photothermal dual-mode detection of glyphosate. | The extensive application of glyphosate (GLY) in modern agriculture has raised increasing concerns regarding environmental contamination and food safety. In this work, a dual-mode hydrogel sensing platform was constructed based on Ce/Zr-MOF with intrinsic peroxidase-like activity. The synthesized Ce/Zr-MOF efficiently ... |
41874125 | Toward Comprehensive In Vitro Evaluation of Serum Albumin Binding of Per- and Polyfluoroalkyl Substances. | Per- and polyfluoroalkyl substances (PFAS) constitute a large and chemically diverse class of synthetic compounds characterized by one or more fully fluorinated methyl or methylene groups. Many PFAS are toxic, environmentally persistent, bioaccumulative, and highly mobile, resulting in widespread contamination and biol... |
41869289 | A Bioinspired Approach to Next-Generation Vaccines in Solid Tumors with Engineered Cell Membranes. | In solid tumors, the immunosuppressive tumor microenvironment and antigenic heterogeneity pose important challenges for effective immunotherapy, often leading to limited T-cell infiltration and inadequate immune activation. To overcome these barriers in solid tumors, the development of next-generation vaccines capable ... |
41869287 | Tunable Interference Colors in Nanofibril-Crystal Composite Films via Integrated Salt-Assisted Assembly. | Cellulose nanofibrils (CNFs) are strong, flexible biopolymers, whereas producing large-area (centimeter-scale) optical films with tunable, vivid interference colors with them remains difficult. The amorphous regions within the fibrils reduce birefringence and prevent uniform color formation. Here, we develop an integra... |
41868343 | Ultra-sensitive IDE-based ammonia sensor fabricated using green synthesized graphene nanoplatelets and a TiO<sub>2</sub> based composite. | The development of a reliable, sensitive, and economical gas sensor is crucial for effective environmental monitoring. In this study, we present the development of an interdigitated electrode (IDE) based graphene nanoplatelet (GnP) and GnP-TiO<sub>2</sub> composite NH<sub>3</sub> gas sensor operated at room temperature... |
41868329 | Adsorptive and photocatalytic strategies for carmoisine removal: mechanisms, material innovations, and environmental implications. | Carmoisine (CM) (also called azorubine or Acid Red 14) poses severe environmental and health risks due to its chemical stability, persistence in environment, and generation of toxic aromatic amines. Conventional treatment methods such as coagulation, oxidation, membrane filtration, and biological degradation are ineffe... |
41866036 | PRAMEL12 orchestrates spermiogenesis to ensure male fertility in mice. | Spermiogenesis, the terminal phase of spermatogenesis, involves complex morphological and molecular changes essential for sperm maturation. While PRAMEL12, a cancer/testis antigen PRAME (preferentially expressed antigen of melanoma) family member, is implicated in spermatogenesis, its specific functions remain poorly u... |
41865247 | Sorbitol modulates the structure and nanomechanics of κ-casein amyloid fibrils. | Amyloid fibrils are highly ordered protein aggregates that, beyond their pathological roles, are increasingly recognized as functional structures in food systems. κ-casein is a particularly interesting model due to its dual relevance: it stabilizes casein micelles in milk but can also form amyloid fibrils under destabi... |
41864448 | Topical delivery of Vismodegib using fourth-generation PAMAM dendrimers: a potential treatment for Kaposi's sarcoma. | The aim of this work was to develop dendrimer-based nanocarriers of Vismodegib (VDG) for the topical treatment of Kaposi's sarcoma (KS). Previous molecular docking studies have shown that VDG is capable of inhibiting cyclooxygenase-2 (COX-2), an enzyme transcriptionally induced by the viral oncoprotein vGPCR and critic... |
41864206 | The E3-ome gene-centric compendium reveals the human E3 ligase landscape. | To define and systematically characterize the human E3 ubiquitin ligase (E3) landscape, we generated the E3-ome, a compendium of E3s encoded by the human genome. The E3-ome integrates experimental data, bioinformatics, and published research, revealing 672 high-confidence E3s. We standardized E3 classifications to crea... |
41863948 | Poly(deep eutectic solvent)@MOF-801 for technical surveillance of carbaryl: Pesticide residue safety control strategy. | Carbamate pesticide residues in agricultural water and crops pose a significant threat to ecological safety and human health. In this research, a DES-mediated surface molecular imprinting strategy was developed to construct a high-performance adsorbent, PDES@MOF-801, for the selective removal of carbaryl from Poria coc... |
41863859 | 2D disposable stochastic strip for ultrasensitive assay of Pb(II) and Cd(II) in sapropel. | Pollution with heavy metals like Pb and Cd may have a strong influence on the quality of sapropel - which is used in cosmetics, or medical treatments. The ultrasensitive on-site assay of Pb(II) and Cd(II) when their concentration is very low is an important issue for both environment and the health of people using the ... |
41863079 | Overcoming the blood‒brain barrier: nanomedicine strategies for targeted delivery and multimodal therapy in Alzheimer's disease. | Alzheimer's disease (AD) remains a significant therapeutic challenge, primarily because the formidable blood‒brain barrier (BBB), which drastically limits the brain bioavailability of most drugs. Nanoparticle-based drug delivery systems offer a promising strategy to overcome this central obstacle. This review systemati... |
41862633 | Visualizing suborganellar lipid distribution using correlative light and electron microscopy. | Lipids and proteins compartmentalize biological membranes into nanoscale domains, which are crucial for signalling, intracellular trafficking and many other cellular processes. Studying nanodomain function requires the ability to measure protein and lipid localization at the nanoscale. Current methods for visualizing l... |
41862458 | A cell cycle-dependent transition of acetylation to phosphorylation regulates timely centrosome maturation. | Centrosomes must undergo maturation in the G2/M phases to activate the microtubule-organizing activity, ensuring proper bipolar spindle assembly and chromosome segregation. Polo-like kinase 1(PLK1) is crucial for centrosome maturation. How the cell cycle controls timely PLK1 recruitment and centrosome maturation remain... |
41862472 | Ultrathin crown ether-based polyamide membrane for ion-ion separations. | Membrane-based liquid separations that selectively extract valuable ionic species from water can enhance resource circularity across industries. However, commercial membranes lack the selectivity required to target specific ions. Here we design crown-ether-based polymeric membranes for ion-ion separations using princip... |
41861381 | Methylene Cycloalkene as a Reactive 1,3-Diene for Enantioselective Hydroamination. | Herein, we report the first enantioselective functionalization of methylene cycloalkenes─an underexplored class of reactive 1,3-dienes. The process involves a palladium-catalyzed enantioselective hydroamination of methylene cycloalkenes using pyrazole derivatives, affording a variety of chiral tertiary amines. A machin... |
41861375 | Thermoresponsive Gels Based on Cross-Linked Polymer-Grafted Cellulose Nanocrystals. | Stimuli-responsive nanocomposite hydrogels have garnered significant interest as alternatives to conventional hydrogels, enabling the engineering of stimuli-responsive behavior and network connectivity through composition and architecture. Here, we report thermoresponsive, "one-component" nanocomposite hydrogels compos... |
41861343 | Precise and Parallel Fabrication of Microactuator Arrays via Interfacial Supramolecular Adhesion. | Scalable manufacturing of microactuators with heterogeneous materials, such as bilayer hydrogels, remains a challenge for soft robotics in collective intelligence and micromanipulation. Current methods, like manual assembly and three-dimensional (3D) printing, limit scalability and result in bulky devices with slow act... |
41861282 | Iodine Capture and Transformation at a Hydrogen-Bond-Stabilized Dimethylammonium Site within a Uranyl-Based MOF. | Due to its high volatility and long half-life, iodine poses a serious threat to the environment and human health. Therefore, trapping radioactive iodine is of significant importance. In this study, a novel uranyl-based metal-organic framework (MOF) material, IHEP-103, was synthesized via a solvothermal process by combi... |
41861124 | Electron-Transfer-Mediated Dynamic Control of Photochromism and Fluorescence/Phosphorescence in a Smart Metal-Organic Framework. | Smart materials whose color and luminescence can be simultaneously tuned by external stimuli are highly desirable for advanced optical and information technologies. Achieving independent yet coupled control over both photochromism and emission, particularly a dual fluorescence-phosphorescence output, remains difficult,... |
41861036 | Interfacial Coupling in Few-Layered Graphene and Metal Organic Framework-Incorporated Poly(vinylidene Fluoride) Nanocomposites Enabling Piezoelectric Energy Harvesting and Piezocatalytic Reduction of Hexavalent Chromium. | This study reports the interfacial engineering of poly(vinylidene fluoride) (PVDF) nanocomposites using a hybrid nanofiller comprising few-layered graphene and a copper-based metal-organic framework (Cu-MOF) to simultaneously enhance piezoelectric energy harvesting and piezocatalytic activity. The nanocomposites were p... |
41861006 | Bacterial enzyme-responsive hydrogels for triggered delivery of antibiotics to infected wounds. | Wound infections are becoming increasingly difficult to treat due to rising antibiotic-resistant bacteria. β-Lactamase-producing bacteria are among the most common pathogens implicated in these infections. Here, we report a bacterial enzyme-responsive hydrogel formulated with a cephalosporin-derived, β-lactamase-cleava... |
41861004 | Membrane-associated Rhes-Slc4a7 complex orchestrates tunneling nanotube formation and mutant Huntingtin spread. | Tunneling nanotubes (TNTs) are membranous structures that mediate intercellular transfer of proteins, including the pathogenic mutant Huntingtin (mHTT) protein in Huntington disease (HD). We previously identified the ras homolog enriched in the striatum (Rhes) as a key regulator of TNT formation and mHTT transmission; ... |
41860945 | Dense and distributed neuropeptide network in the nerve net of Hydra vulgaris. | Neuroscience has long emphasized synaptic transmission and physical wiring as the substrate of brain function and behavior. However, an additional layer of connectivity - a "chemical connectome" formed by neuropeptide-GPCR signaling - has been increasingly recognized in animals such as C. elegans, Drosophila, and the c... |
41860940 | Curvature of the Drosophila corneal lens depends on localized chitin secretion. | The Drosophila corneal lens is an apical extracellular matrix structure with a biconvex shape that enables it to focus light onto the underlying photoreceptors. Here, we investigated how this shape is influenced by the source of one of its major components, the polysaccharide chitin. Knocking down the chitin synthase K... |
41860929 | Targeting Leishmania donovani Sphingosine Kinase 1 using PF-543 enhances immune response and limits parasite load. | <h4>Background</h4>Sphingosine-1-phosphate (S1P) is a bioactive lipid mediator regulating apoptosis, proliferation, and immune responses. While S1Ps presence in Leishmania donovani phagolysosomes has been reported, the role of sphingosine kinases, especially SphK1, in parasite survival and host immune modulation remain... |
41860750 | Pairs of Zirconium Site and Hydroxyl in MOFs Enable Generating Peroxo Species for Efficiently Tandem Oxidative Condensation of Aromatic Amines. | Selective oxidation of aromatic amines to azoxyarenes is important but challenging owing to complex reaction pathways. Here, we report that constructing pairs of Lewis acidic Zr sites and terminal hydroxyl in zirconium trimesate MOF-808 enables activation of H<sub>2</sub>O<sub>2</sub> for the formation of non-radical Z... |
41860727 | Chiral Metal Halide Perovskites for Spin-Polarized Light-Emitting Diodes. | With the growing importance of displays, reducing their power consumption has become crucial for developing energy-efficient photonic-electronic platforms. Conventional light emitting diodes (LEDs) rely on external polarizers and waveplates to control light polarization in displays, but these optics cause at least half... |
41860403 | Towards the design of ionic traps incorporating thermolabile units: structural characterization of copper(II), palladium(II) and rhodium(II) complexes with the aminoalcohol ligand 2-(pyridin-2-ylamino)ethanol. | Aminoalcohol-based ligands incorporating heteroaromatic moieties, such as 2-(pyridin-2-ylamino)ethanol (L<sup>1</sup>), are of particular interest in coordination chemistry due to their dual donor character and conformational adaptability. A series of L<sup>1</sup>-based transition-metal complexes, namely, diacetatobis... |
41860406 | Copper-based semiconductor nanocrystals for optical applications. | Copper-based semiconductor nanocrystals (SNCs) are a broad class of nanomaterials that include pnictogenides, chalcogenides, and halides. The breadth of compositions, crystal structures, and electronic properties displayed by these SNCs is reflected in their rich photophysics, which can underpin strong photon absorptio... |
41860393 | In Situ Synthesis and Defect Engineering of MOF-76 by Electron Beam Irradiation: Balancing Crystallinity and Defects for Uranyl Capture. | High-energy electron irradiation provides an exceptionally fast, energy-dense route to fabricate porous crystalline frameworks, yet its utility for MOFs is fundamentally limited by a trade-off between accelerated crystallization and radiation-induced damage. Here, we show that this trade-off can be actively navigated b... |
41860382 | On and Off Deformability of Supramolecular Micelles in the Soft Frank-Kasper σ Phase. | Deformability is a key pathway to structural complexity in self-assembled systems. Although numerous molecular systems have been engineered to form Frank-Kasper (FK) phases, they typically rely on size- or shape-based asymmetries rather than new structural degrees of freedom. By incorporating chain-length asymmetry int... |
41860252 | Surfactant-mediated porous MOF-5 for high-performance triboelectric nanogenerators. | In this study, high-performance triboelectric nanogenerators (TENGs) were developed by incorporating porous metal-organic frameworks (MOFs) into the device structure. A highly porous MOF-5 was prepared <i>via</i> a surfactant-mediated solvothermal process and employed as the positive triboelectric layer in a TENG devic... |
41860144 | Crystalline Dion-Jacobson 2D Layered Sn-Based Perovskites for Field-Effect Transistors. | Dion-Jacobson (DJ) phase perovskites are increasingly recognized as potential semiconductor materials for electronic applications. However, the restricted coordination between the organic diammonium cations and the inorganic framework inhibits their self-assembly into efficient DJ Sn-based perovskites during solution p... |
41859952 | Comparison of Pleated and Rippled β-Sheet Assembly of Sequence Isomers of an Amphipathic Self-Assembling Peptide. | Supramolecular β-sheet peptide nanomaterials are of critical interest due to their relevance in amyloid disorders and are increasingly valued for applications in regenerative medicine, tissue engineering, and antimicrobial design. Amphipathic peptides, particularly those with alternating hydrophobic and hydrophilic res... |
41858298 | Research Progress of Porous Framework-Based Triplet-Triplet Annihilation Upconversion Materials. | Triplet-triplet annihilation upconversion (TTA-UC) is an anti-Stokes process that converts low-energy photons into high-energy photons, holding significant promise for applications in solar energy harvesting, photocatalysis, and bioimaging. However, the main operating environment for efficient TTA-UC is an oxygen-free ... |
41858286 | Parametrization of β<sup>3</sup>-Peptides for Coarse-Grained Molecular Dynamics Simulations. | Coarse-grained simulations of foldamers such as β-peptides require force fields that accurately capture the backbone geometry and flexibility. In this work, we extend the UNRES coarse-grained model to β<sup>3</sup>-peptides by reparameterizing key local potential terms: virtual-bond stretching, virtual bond-angle bendi... |
41858249 | Dynamic Supramolecular Polyurethane Elastomers Enabling Bioinspired Strain-Adaptive Stiffening to Resolve the Softness-Strength Paradox. | The rapid progress of soft robotics and flexible electronics has sparked tremendous demand for elastomers that unite high mechanical strength with intrinsic softness, thereby mimicking the mechanical performance of natural skin. Herein, we report a class of dynamically crosslinked supramolecular polyurethanes that comb... |
41858245 | Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond. | Gaseous mediators are increasingly recognized as critical regulators of human physiology and pathology, offering unique therapeutic opportunities that are fundamentally constrained by challenges in controlled delivery, spatial targeting, and biological specificity when harnessed through advanced delivery technologies. ... |
41858179 | Science-Towards-Technology Breakthrough in CO<sub>2</sub> Electroreduction: Multiphysics, Multiscale, and Artificial Intelligence Insights. | Electrochemical carbon dioxide reduction reactions (eCO<sub>2</sub>RR) are a key technology for converting greenhouse gas CO<sub>2</sub> into high-value-added chemicals. In recent years, significant progress has been made in material design, catalytic mechanism analysis, and electrolyzer optimization. However, there re... |
41858173 | Ultrasound-Responsive Dual-Prodrug Nanoassembly for "Fenestrae-Restoration Strategy" in Liver Fibrosis Therapy. | Liver fibrosis is a serious yet reversible intermediate stage in the progression of liver disease, which can ultimately advance to cirrhosis and hepatocellular carcinoma. Targeted and selective inhibition of activated hepatic stellate cells (aHSCs) has emerged as a promising therapeutic strategy for the treatment of li... |
41857034 | Carbene-catalyzed double esterification enables enantioselective conformational self-locking of pillar[5]arenes. | For their chirality, pillar[5]arenes stand out among the most versatile and widely utilized classes of organic host molecules, with numerous applications in materials science and biomedicine. The chirality of these macrocyclic compounds arises from conformational locking induced by sterically demanding substituents. Ho... |
41843741 | Crystal structure of the <i>Legionella pneumophila</i> effector SidL (Lpg0437) in complex with its metaeffector LegA11 (Lpg0436). | <i>Legionella pneumophila</i> is an opportunistic human pathogen that causes atypical pneumonia called Legionnaires' Disease. To replicate within host cells, <i>L. pneumophila</i> injects up to 330 effector proteins into the host cytosol via a Dot/Icm type IV secretion system. Several effectors, called metaeffectors, r... |
41971066 | Modulating G-quadruplexes for therapeutic intervention: Structural diversity, stability, and emerging nucleic-acid-based strategies. | G-quadruplexes (G4s) are non-canonical nucleic acid structures formed by guanine-rich DNA or RNA sequences. The G4s are formed by planar G-tetrads and stabilized by monovalent metal cations such as potassium or sodium. The structural diversity of G4s arises from differences in strand orientation, loop arrangement, and ... |
41970236 | Recent advances in bismuth-based heterojunction photocatalysts. | Layered bismuth-based (LBB) nanoparticles, characterized by a unique crystal structure, offer precise control over flaws, band topologies, and morphology, enhancing solar conversion efficiency. Bi's 6s and O's 2p orbitals' hybridization results in a reduced band gap, facilitating improved photo absorption and efficient... |
41953715 | Aptamer-guided upconversion nanoconstructs enable proximity-dependent and precise photodynamic therapy for MRSA-infected wounds. | Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) infections lead to slow wound healing, but treating these wounds with conventional photodynamic therapy (PDT) remains challenging because they induce non-specific oxidative damage on healthy tissue, thereby hindering wound repair. To achieve efficient antibacter... |
41943293 | From formulation proxies to control variables: A mechanistic framework for high-methoxyl pectin gelation and matrix organisation. | High-methoxyl pectins (HMPs) have been the primary gelling agents in classic fruit systems with high sugar content and low pH for decades. Despite their widespread technological use, the field still lacks a coherent mechanistic framework comparable to the egg-box model established for low-methoxyl pectins. The literatu... |
41939900 | Multi-omic profiling converges on proteasome subunits PSMA7/PSMB2 as targets of the sepsis-protective agent Handelin. | <h4>Introduction</h4>Sepsis is a life-threatening systemic inflammatory syndrome with limited targeted therapeutic options. Handelin, a natural compound derived from Chrysanthemum indicum, exhibits anti-inflammatory activity, yet its direct targets and protective mechanisms in sepsis remain unclear.<h4>Methods</h4>We e... |
41939836 | Linagliptin loaded chitosan nanoparticles for the efficient therapy of renal fibrosis. | Chronic kidney disease (CKD), whose prevalence is rising substantially, has become a major global health challenge. In this study, we developed linagliptin-loaded chitosan nanoparticles (HCS-LGP NPs) for the treatment of renal fibrosis. The synthesized nanoparticles exhibited a uniform particle size of 178.8 ± 4.4 nm a... |
41939706 | Growth-associated polyhydroxybutyrate accumulation in <i>Azospira suillum</i> PS during aerobic and perchlorate respiration. | Polyhydroxyalkanoates (PHAs) are widespread microbial storage polymers increasingly recognized for roles beyond carbon and energy storage, including redox homeostasis and stress physiology. While PHA accumulation is classically associated with stationary-phase metabolism under severe nutrient imbalance, comparatively l... |
41939708 | Synergistic effects of fecal microbiota transplantation and andrographolide on gut microbiota modulation in dextran sulfate sodium-induced colitis in mice. | <h4>Background</h4>Andrographolide (Andro) and fecal microbiota transplantation (FMT) are emerging treatments for colitis. However, whether their combined administration provides superior efficacy has not been established.<h4>Methods</h4>This study attempted to clarify the reparative effects of FMT, Andro, and their co... |
41939439 | Intranasal drug delivery: Unlocking the nose-to-brain route for central nervous system therapies. | Intranasal drug delivery is rapidly gaining momentum as a game-changing approach for central nervous system (CNS) therapies, owing to its ability to bypass the blood-brain barrier (BBB) <i>via</i> olfactory and trigeminal pathways. It also enables systemic drug absorption while avoiding the metabolic drawbacks of oral ... |
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