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41705417 | The journey of short peptides: from molecules to materials. | Peptide-based supramolecular systems consisting of conserved sets of building blocks and chemical reactions play a crucial role in the fabrication of supramolecular soft materials. Their inherent capacity for self-assembly, biocompatibility, and molecular tunability make them attractive candidates for creating peptide-... |
41700389 | The supramolecular architecture of amyloid fibrils formed by a human tau-derived hexapeptide VQIVYK. | The sequence <sub>306</sub>VQIVYK<sub>311</sub> is an aggregation-prone region of the tau protein implicated in driving the assembly of tau into paired helical filaments. These filaments accumulate as intraneuronal neurofibrillary tangles in Alzheimer's disease and a range of tauopathies. Prolonged incubation of VQIVYK... |
41988371 | Chemically Defined Non-human Glycans Comprising Galactose-α1-3-Galactose (α-Gal) Epitopes Glycoengineered into the Fragment Antigen-Binding (Fab) Domain of Cetuximab Differentially Affect Human Anti-α-Gal Immunoglobulin E (IgE) Binding. | Glycosylation of monoclonal antibodies (mAbs) critically affects their effector function, stability, pharmacokinetics, and immunogenicity. Glycan structures can vary with cell type and culture conditions and are often considered key critical quality attributes that must be tightly controlled. While most mAbs are glycos... |
41982930 | Influence of molecular shape and hydrogen bonding on glycolipid self-assembly into thermotropic gyroid phases. | Periodic network morphologies such as the double gyroid (DG) are promising for a wide range of applications, from optical materials and organic semiconductors to separation membranes and drug delivery vehicles. While natural glycolipids are a constituent of cell membranes, synthetic glycolipids have emerged as candidat... |
41978732 | Identification and genomic characterization of BA.3.2: a highly divergent BA.3-related SARS-CoV-2 lineage from southern Africa. | In November 2024, a highly divergent BA.3-related severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineage, designated BA.3.2, was detected in South Africa, marking the first appearance of a BA.3-derived lineage in over 2 years. Phylogenetic reconstruction places BA.3.2 on an extended branch descending from... |
41965299 | Pt(Ⅱ) complexes-based hollow nanospheres with aggregation-induced electrochemiluminescence as dual-functional nanoaccelerators for ultrasensitive detection of cancer biomarkers in human serum. | <h4>Background</h4>Platinum (II) complexes with aggregation-induced electrochemiluminescence (AIECL) properties exhibit great potential for clinical disease detection. However, it still has great challenge to develop high-performance biosensors that can achieve precise control over their functionalization and ordered s... |
41948405 | Unveiling Clusterization-Triggered Emission Mechanism Through a Small-Molecule Clusteroluminogen with Color Tunable and White-Light Emission. | Clusterization-triggered emission (CTE) is a photophysical phenomenon where clusteroluminogens (CLgens) generate efficient luminescence through supramolecular self-assembly in the solid state. This phenomenon offers unique photophysical properties, distinguishing it from traditional chromophores. In the context of ligh... |
41943316 | Sustainable polysaccharide-based adsorbents for PFAS removal: Mechanisms, functional engineering, and future directions. | Per- and polyfluoroalkyl substances (PFAS), often described as "forever chemicals," continue to challenge water treatment technologies because of their exceptional chemical stability, tendency to accumulate in the environment, and resistance to conventional remediation processes. In recent years, naturally derived poly... |
41939395 | Temporal Dynamics and Uptake Mechanisms of Carbonated Hydroxyapatite Nanoparticles in Murine F‑OST Cells. | Carbonated hydroxyapatite (CarboHA) is a biomaterial gaining attention for its biocompatibility, bioactivity, and expanding applications in bone regeneration, aesthetic biostimulation, dentistry, and drug delivery systems. However, the impact of synthesis conditions on its physicochemical properties and cellular intern... |
41939359 | Catalytic Applications of MXene-Based Materials and Their Derivatives. | MXenes, a fast-growing family of 2D transition metal carbides and nitrides (M <sub><i>n</i>+1</sub>X <sub><i>n</i></sub> T <sub><i>x</i></sub> ), have demonstrated remarkable catalytic potential because of their layered structure, tunable surface terminations, and metallic conductivity. They are perfect for important p... |
41939319 | Eco-Friendly Synthesis of AuPd Bimetallic Nanoparticles Using <i>Alpinia zerumbet</i> for Efficient Reduction of Nitro Compounds. | The development of sustainable nanocatalysts is an important challenge in modern chemistry, with the aim of replacing conventional synthesis routes that employ toxic reagents and harsh conditions. In this work, we report the eco-friendly synthesis of AuPd bimetallic nanoparticles, using <i>Alpinia zerumbet</i> extract ... |
41939300 | Removal of Glyphosate from Water by Adsorption Using the Zeolitic Imidazolate Framework ZIF-8: Characterization of Equilibrium Isotherms and Adsorption Kinetics. | Glyphosate, an anionic organophosphorus herbicide, is frequently detected in surface waters alongside other emerging contaminants (ECs). Effective removal strategies are essential to reduce their environmental impact. This study synthesized a metal organic framework (MOF) called Zeolitic Imidazolate Framework-8 (ZIF-8)... |
41929844 | Recent advances in metal-organic framework as nanocarriers for pesticide delivery. | The excessive use of conventional agrochemicals has led to severe environmental contamination, low utilization efficiency, and increasing concerns regarding ecological safety and sustainability. In recent years, metal-organic frameworks (MOFs) have emerged as a versatile class of porous materials for advanced agrochemi... |
41929836 | FgGCV1, a glycine cleavage system T protein, regulates glycine metabolism and sexual reproduction in <i>Fusarium graminearum</i>. | Fusarium head blight (FHB), caused by several <i>Fusarium</i> species, among which the most important and widely distributed worldwide is <i>Fusarium graminearum</i>, in the case that the causal agent is <i>F. graminearum</i>, FHB spread is closely linked to the pathogen's sexual reproduction. The T protein of the glyc... |
41929773 | <i>Rehmannia glutinosa</i> polysaccharides: a review on structural features, pharmacological potential, and advanced delivery systems. | <i>Rehmannia glutinosa</i> polysaccharides (RGPs) are recognized for their diverse pharmacological potential. However, their translation into practical applications faces significant hurdles. The primary challenges include their intrinsic structural complexity, poor oral bioavailability, and poorly defined structure-ac... |
41929685 | Sijing Pill modulates PGE2/EP4/PI3K-AKT pathway via gut-bone axis to treat postmenopausal osteoporosis. | <h4>Introduction</h4>Postmenopausal osteoporosis (PMOP) represents a substantial clinical burden for aging women worldwide. Existing pharmacotherapies are frequently constrained by suboptimal efficacy, poor adherence, and adverse effects, underscoring the need for superior treatment alternatives. The Sijing Pill (SJP) ... |
41929683 | The differences in hypoglycemic activity of Coptis herb pairs fermented by <i>Eurotium cristatum</i> and its regulatory effect on gut microbiota in T2DM rats. | Coptidis Rhizoma-Scutellariae Radix, Coptidis Rhizoma-Glycyrrhizae Radix et Rhizoma, and Coptidis Rhizoma-Panax notoginseng are herbal pairs widely used in clinical therapy for Type 2 Diabetes Mellitus (T2DM) and gastrointestinal diseases. The fungus <i>Eurotium cristatum</i>, known for its robust enzyme system and div... |
41929426 | Resistance mechanisms of bacterial biofilms on orthopedic implants and research progress on novel anti-biofilm coatings. | Implant-associated infections (IAIs) have become a major challenge in clinical orthopedics due to the formation of bacterial biofilms and their complex resistance mechanisms. This review systematically summarizes the resistance mechanisms of bacterial biofilms on the surface of orthopedic implants and critically analyz... |
41929254 | A review of the pharmacological mechanism of corosolic acid. | Corosolic Acid (CA), a pentacyclic triterpenoid found in plants like Lagerstroemia speciosa, exhibits a wide array of preclinical pharmacological activities, including hypoglycemic, anti-cancer, anti-inflammatory, antioxidant, and cardiovascular protective effects. Often dubbed "plant insulin," its therapeutic potentia... |
41929244 | MG53 protects against intestinal inflammation by inhibiting NLRP3 inflammasome activation. | <h4>Background and objectives</h4>Inflammatory bowel disease (IBD) involves dysregulated immune responses and chronic intestinal inflammation. The nod-like receptor pyrin domain-containing 3 (NLRP3) inflammasome plays a critical role in IBD pathogenesis, but regulatory mechanisms remain not fully understood. Mitsugumin... |
41929239 | Designing and immuno-informatics evaluation of a multi-epitope vaccine targeting lipoprotein A-4'-phosphatase (LpxF) for <i>Helicobacter pylori</i> infection control. | <h4>Introduction</h4>The WHO has classified <i>Helicobacter pylori</i> as a category 1 carcinogen and a major causative agent of gastrointestinal ulcers, gastric adenocarcinoma, and gastric lymphoma. While antibiotics and proton pump inhibitors are effective treatments, they are associated with risks of reinfection, pa... |
41929236 | A multi-epitope pan-betacoronavirus vaccine construct predicted to induce broad-spectrum and durable immune responses: an immunoinformatics approach. | <h4>Introduction</h4>Recurrent zoonotic spillovers and continuous antigenic evolution among betacoronaviruses, including SARS-CoV, MERS-CoV, and SARS-CoV-2, highlight the urgent need for a broad-spectrum vaccine capable of eliciting cross-protective immunity. Conventional vaccines, although effective against specific s... |
41928883 | Post-vaccination SARS-CoV-2 infections and antibody responses after BNT162b2 in patients with severe obesity: a retrospective cohort study. | <h4>Aim</h4>The aim of this study was to describe the frequency of post-vaccination SARS-CoV-2 infection and to compare SARS-CoV-2 IgG antibody levels between patients with severe obesity and individuals without obesity after two doses of the BNT162b2 vaccine.<h4>Methods</h4>One hundred two consecutive patients with se... |
41928775 | Next-generation nanomaterials for environmental remediation: smart design, hybrid materials and sustainable use. | Environmental contamination has increased steadily over recent decades due to industrialization, urban expansion, intensive agriculture, and improper waste management. As a result, a wide range of pollutants, including per- and polyfluoroalkyl substances (PFAS), microplastics, pharmaceutical residues, endocrine-disrupt... |
41918711 | Synthesis and uranyl(VI) extraction performance of a calix[4]pyrrole-tetrahydroxamic acid receptor. | The contamination of water by uranium poses a serious threat to ecosystems and human health, creating a need for efficient and selective remediation strategies. Supramolecular materials, with their pre-organized structures, offer a promising route for uranium removal. Phenoxycalix[4]pyrroles (PCP) are well-known supram... |
41909507 | Marine collagen for regenerative medicine: Structure-function advantages, limitations, and translational pathways. | Marine collagen is emerging as a transformative natural-derived material in regenerative medicine. Unlike traditional mammalian collagen, it has unique structural properties (e.g., a distinct amino acid profile) that confer high biocompatibility and low immunogenicity, along with excellent antibacterial activity and a ... |
41909509 | Nanomaterial-driven modulation of lipid metabolism: Novel strategies toward precision obesity treatment. | Obesity treatment is entering a new era with the advent of multifunctional nanomaterials capable of precise biological intervention. This review highlights their pivotal role in overcoming key therapeutic limitations, including poor targeting, systemic toxicity, and low bioavailability. Based on the systematic analysis... |
41909510 | A catalytically active and recyclable bioelastomer inspired by metalloenzymes. | Catalysis is a fundamental principle of biological systems, yet synthetic biomaterials seldom incorporate catalytic activity as a core design principle. Here, we introduce a polymeric network constructed by crosslinking imidazole-functionalized polymers using Cu<sup>2+</sup> ions, yielding an elastomer with enzyme-mime... |
41901136 | Dietary β-1,3/1,6-Glucan from Baker's Yeast Supports Upper Respiratory Mucosal Immune Health in Healthy Adults: Evidence from a Randomized, Double-Blind, Placebo-Controlled Trial. | <b>Background/Objective</b>: Dietary polysaccharides are increasingly recognized as functional nutritional components that support human health through modulation of immune function. However, clinical evidence linking their intake to site-specific upper respiratory mucosal immune health in humans remains limited. This ... |
41901016 | Identification of Glycoprotein Biomarkers in Breast Cancer by MALDI. | Protein glycosylation plays a pivotal role in breast cancer biology, influencing cell proliferation, adhesion, migration, and immune evasion. Aberrant N- and O-glycosylation are hallmarks of neoplastic transformation and serve as sensitive indicators of disease progression. This review aims to characterize glycoprotein... |
41901015 | Chemical Routes to Primitive Membranes: Prebiotic Lipid Formation at the Origin of Life. | The origin of life is, to the best of our knowledge, impossible to imagine without the formation of complex prebiotic biomolecules such as RNA, DNA, proteins and lipids. Lipids play a crucial role in the spontaneous formation of cell membranes, which are responsible for cell integrity, compartmentalization, selective p... |
41900678 | Hollow Graphitic Nanoshells as a Material for Ion Batteries. | Hollow graphitic nanoshells (HGSs) are widely investigated as battery materials because their conductive shells and internal voids can simultaneously influence ion transport, electron percolation, and mechanical stress accommodation. Yet, the field remains largely morphology-driven, with performance often attributed ge... |
41900446 | Bacterial Membrane Vesicles: Biogenesis, Functions, and Emerging Biotechnological Applications. | Bacterial membrane vesicles (BMVs) are non-replicative, bilayered nanostructures secreted by both Gram-negative and Gram-positive bacteria. Rather than being passive byproducts of cell envelope turnover, BMVs are increasingly recognized as regulated particles that selectively package proteins, lipids, nucleic acids, an... |
41900119 | Mirror Effect of Parvalbumin and Connexin 43 Expression in the Acute and Subacute Phases After Penetrating Traumatic Brain Injury Reveals a Non-Canonical Interaction. | Traumatic brain injury (TBI) initiates a cascade of molecular and cellular reactions leading to long-term disturbances of neuronal and glial homeostasis. One of the key mechanisms of secondary injury is a pathological increase in intracellular Ca<sup>2+</sup> concentration. Parvalbumin (PV) plays an important role in t... |
41900120 | Boron's Double Edge-Antibiotics, Toxins, and the Fine Line Between Them. | Boron is a chemically distinctive bioelement whose electron-deficient structure enables reversible coordination with oxygen-rich functional groups such as diols and hydroxyls. This property allows boron to modulate molecular stability, conformation, and biological reactivity, giving rise to both beneficial pharmacologi... |
41900118 | Biowaiver Monographs for Immediate-Release Solid Oral Dosage Forms: Meloxicam. | This monograph evaluates the scientific and regulatory underpinnings for bioequivalence (BE) waiver of immediate-release (IR) solid oral meloxicam formulations, as a surrogate for in vivo pharmacokinetic trials. In compliance with ICH (The International Council for Harmonisation of Technical Requirements for Pharmaceut... |
41900114 | Herbal Textual Research, Phytochemistry, Pharmacology and Toxicity of Atractylodis Rhizoma: A Comprehensive Review. | This review examines the historical development, ethnopharmacology, traditional applications, phytochemistry, and pharmacological attributes of Atractylodis Rhizoma (AR). Data were collected from a range of electronic databases, academic libraries, and classical literature. In China, AR is highly valued for its medicin... |
41899235 | Overcoming Chemotherapy Resistance in Triple-Negative Breast Cancer with Nanocarrier-Delivered siRNA Therapeutics. | Triple-negative breast cancer (TNBC) represents 10-20% of breast cancers and is characterized by the absence of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression, leaving cytotoxic chemotherapy as the main systemic treatment. However, rapid development of resistance, via ... |
41898626 | Boron Neutron Capture Therapy for High-Grade CNS Tumors: Mechanisms, Carriers, and Clinical Progress: A Narrative Review. | Boron neutron capture therapy (BNCT) is a biologically targeted, high-linear energy transfer radiotherapy that selectively delivers cytotoxic α-particles to boron-loaded tumor cells and has re-emerged with the development of hospital-compatible accelerator neutron sources and improved boron carriers. We performed a str... |
41898622 | Hypoxic Pulmonary Hypertension: Molecular Mechanisms and Clinical Research Advances. | Hypoxic pulmonary hypertension (HPH), classified as Group 3 pulmonary hypertension in the current clinical classification system, represents a complex and progressive cardiopulmonary disorder characterized by elevated pulmonary arterial pressure due to chronic alveolar hypoxia. This condition significantly contributes ... |
41897930 | Fecal Microbial Community Characteristics of Oula and Hu Sheep and Their Correlation with Semen Quality. | Semen quality and fecal microbial composition were compared between native Oula rams reared on the Qinghai-Tibet Plateau and Hu sheep rams introduced from lowland regions. Semen quality was analyzed in eight adult Oula rams and eight Hu rams, and fecal microbial composition was assessed via 16S rRNA sequencing. Results... |
41897789 | Upcycling Tomato Harvest and Processing Residues into Polyphenol-Enriched Cellulosic Films with Tunable Antioxidant and UV-Blocking Properties. | The development of bio-based functional materials through the upcycling of agri-food residues represents a sustainable strategy to reduce environmental impact and promote circular economy. This study achieved valorization by combining two tomato by-products: peels exhausted after supercritical fluid extraction and harv... |
41897787 | Enhanced Real-Time Detector for Industrial Vision-Based Corn Impurity Detection. | The effective cleaning of corn prior to storage is crucial for ensuring grain quality and safety. Traditional Convolutional Neural Network (CNN)-based detection methods often struggle to maintain accuracy in scenarios with dense occlusions. Furthermore, limitations in image quality and feature representation hinder the... |
41897391 | Peptide Drugs in Gastrointestinal Tumors: Integrating Targeting, Delivery, and Therapeutic Actions for Synergistic Strategies. | Gastrointestinal malignant tumors account for approximately one-third of global cancer-related deaths, primarily including colorectal, gastric, pancreatic ductal adenocarcinoma, and hepatocellular carcinomas. These tumors have a high incidence, are often asymptomatic, and are prone to metastasis and recurrence, posing ... |
41892578 | Preparation and Performance Evaluation of a Supramolecular Gel Plugging Agent for Severe Lost Circulation Gas Reservoirs. | The plugging of fractured gas reservoirs with severe lost circulation during oil and gas drilling and production has long been challenged by technical issues such as low plugging strength and short effective duration. This paper reports the preparation of a high-strength supramolecular gel plugging agent via micellar c... |
41883854 | Organic photochemistry for direct light-driven separations. | Compared to conventional methods, direct light-driven separations are promising strategies to achieve high selectivity while lowering energy cost. This perspective examines recent progress in photoswitch-enabled separations with a focus on concentration of CO<sub>2</sub> and selective anion recovery from water. We high... |
41881983 | Reactive oxygen species (ROS) in cancer: from mechanism to therapeutic implications. | Reactive oxygen species (ROS) act as critical secondary messengers in various intracellular signaling pathways that regulate cellular proliferation, differentiation, and survival under normal physiological conditions. However, dysregulation of redox signaling-driven by genetic mutations, epigenetic alterations, and pos... |
41880978 | First dose of cationic dendrimers determines the development of resistance or sensitivity to nanomaterials and antibiotics simultaneously in Pseudomonas aeruginosa. | Cationic dendrimers are considered among the most promising antibacterial agents, whose mechanism of action involves destabilizing the outer membrane of Gram-negative bacteria. Despite being considered an alternative to antibiotics, these systems can lose their effectiveness with prolonged use. Although bacterial resis... |
41873359 | Intranasal Nano-Delivery Systems: Emerging Strategies for Central Nervous System Disease Therapeutics. | The rising global incidence of central nervous system (CNS) diseases, exacerbated by the formidable blood-brain barrier (BBB) hindering effective drug delivery, necessitates novel therapeutic strategies. Nasal administration has emerged as a promising non-invasive route, bypassing the BBB via direct neural pathways (ol... |
41873355 | Dual Regulation of Post-Translational Modification of Proteins: Bottlenecks and Breakthroughs in NK Cell Therapy for Glioblastoma. | Glioblastoma (GBM) is the most malignant primary central nervous system tumor in adults, with strong invasiveness, high recurrence, and poor prognosis. Natural killer (NK) cells, innate immune cells that eliminate glioma stem cells without MHC matching, show promise for GBM immunotherapy, but their efficacy is limited ... |
41865723 | RSM-GA-BP optimization of Ultrasound-Enzyme-Assisted deep eutectic solvent extraction (UEADESE) for flavonoids from Abelmoschus manihot (L.) leaves and mechanistic insights. | This study aimed to optimize the ultrasonic-enzyme-assisted deep eutectic solvent extraction (UEADESE) Abelmoschus manihot (L.) leaves flavonoids (AMLF) and elucidate the underlying mechanisms. Screening of extraction parameters was first performed via single-factor experiments, followed by optimization using response ... |
41864142 | Phenylboronic acid and geraniol co-modified chitosan oligosaccharide derivatives boost antibacterial efficacy by targeting bacteria. | Chitosan oligosaccharide (COS) derivatives present significant potential as antimicrobial agents. Our previously developed geraniol (Ger) grafted Chitosan oligosaccharide (COS-Ger) has demonstrated commendable solubility and antibacterial activity. To further improve its effectiveness, exploring methods for bacterial t... |
41864030 | Tunable-defect-rich MOF Cctc@UiO-66-NH<sub>2</sub> for recovery of palladium in metallurgical wastewater: Performance and mechanism. | Palladium is a vital industrial precious metal, whose improperly discharged palladium-containing wastes give rise to cumulative heavy metal contamination of environmental media. The efficient recovery of palladium requires high performance adsorbents. This study selects the dicarboxylic acid Bis(carboxyl)-functionalize... |
41862041 | Optimized laminin surfaces induce spontaneous myelination by neonate mice dorsal root ganglia. | Peripheral nervous system myelination requires tightly coordinated structural and calcium-dependent communication between sensory axons and Schwann cells, processes that are profoundly influenced by extracellular matrix architecture. Here we describe a neonatal mouse dorsal root ganglia explant co-culture grown on lami... |
41861894 | Fabrication of NIR and ROS-responsive β-cyclodextrin/hyaluronic acid-based hybrid hydrogel for the treatment of HER2-positive gastric cancer cells. | The combined therapeutic approaches by unique biomaterial have great attention for gastric cancer therapy with peritoneal metastasis. In this research report, we designed NIR-responsive Fe<sub>3</sub>O<sub>4</sub>@MIL-100(Fe)-Upconversion nanoparticles (FMUNPs) functionalized injectable β-cyclodextrin/hyaluronic acid m... |
41861873 | Synergistic bimetallic competition and defect engineering in hierarchically porous MOF-enzyme composites to enhance the enzymatic synthesis of rare ginsenoside CK. | The confinement effect of microporous MIL-88B(Fe) significantly limits enzyme immobilization efficiency and mass transfer, particularly for bulky ginsenoside substrates. To address this challenge, we propose a synergistic strategy that integrates bimetallic competitive coordination and defect engineering to construct a... |
41861766 | Indium doping induces morphological and electronic structure optimization of nickel-thiophene-based metal-organic frameworks for enhanced oxygen evolution reaction performance. | Modulating the intrinsic structure of metal-organic frameworks (MOFs) is considered as a useful strategy for achieving high-efficiency oxygen evolution reaction (OER). In this paper, we demonstrate the doping of nickel-thiophene metal organic framework (Ni-TDC) with the p-block metals indium (In) to modulate their micr... |
41861460 | Solar-driven dye wastewater purification and synergistic desalination by an aerogel-based multitasking platform structured with polydopamine-hybridized covalent organic frameworks. | For water remediation devices, enhancing the capability to perform multiple tasks and adapt to complex water environments remains a huge challenge. Herein, we reported an aerogel-based platform built with polydopamine-hybridized covalent organic frameworks (COF-R/PDA) for synergistic dye degradation and desalination. B... |
41859510 | Switching between photochromism and photoluminescence in Schiff base derivatives by molecular design of end groups. | Ensuring the security and reliability of information has increasingly become a key issue for modern society, placing greater demands on encryption technologies and anti-counterfeiting materials. Therefore, the development of intelligent responsive materials with multi-mode encryption and protection capabilities has bec... |
41859374 | Structural and bactericidal properties of imidazolium ionic liquid-based micelles of thyme essential oil. | We report the structural and bactericidal properties of the imidazolium ionic liquid (IL)-based micelles of <i>Thymus capitatus</i> (thyme) essential oil (EO). The formation of micelles was investigated by contact angle measurements, which revealed a critical micelle concentration (CMC) of 2.5-3 µM for the IL mixed wit... |
41859370 | Expired chlorzoxazone/<i>N</i>-acetyl-<i>para</i>-aminophenol as corrosion inhibitor for 304 stainless steel in hydrochloric acid. | The influence of the expired drug chlorzoxazone (<i>N</i>-acetyl-<i>para</i>-aminophenol) on the corrosion behavior of 304 stainless steel (304SS) in 1.0 M hydrochloric acid was examined. Several electrochemical measurements were investigated, including open circuit potential (OCP), cyclic voltammetry (CV), potentiodyn... |
41859369 | Assessment of the interaction between sodium dodecyl sulfate and trypsin enzyme through micellization and thermodynamic analysis. | This study investigates the micellization behavior of a system comprising sodium dodecyl sulfate (SDS) and a biologically relevant protein, trypsin as well as the effects of different sodium salts and temperature on that system. The results reveal complex interactions among the surfactants, enzymes, and electrolytes, p... |
41859368 | Smart microdevices for biomedical drug delivery: endogenous stimuli as the key to safer therapeutics. | The landscape of drug delivery has undergone a transformative shift with the emergence of adaptive therapeutics, smart microdevices engineered to respond dynamically to specific physiological or externally applied stimuli. These stimuli-responsive systems represent a significant advancement over conventional delivery m... |
41858929 | Advancement in photocatalytic degradation of ciprofloxacin: mechanisms, materials and environmental remediation. | Ciprofloxacin (CIP), a widely used fluoroquinolone antibiotic, poses significant ecological risks due to its persistence in water systems and contribution to antibiotic resistance. Traditional wastewater treatment methods are ineffective in completely degrading CIP, necessitating more advanced solutions. This review ex... |
41856287 | Targeting Nipah virus replication: A fluorescence polarization assay for high-throughput modulators screening against the N<sub>TAIL</sub>-XD interaction. | Nipah virus (NiV) is a biosafety level 4 pathogen for which no licensed antiviral or vaccine is currently available. Given its pandemic potential and the serious threat it poses to human health, there is an urgent need for robust assays enabling the screening of chemical libraries in search of antiviral candidates. Her... |
41856185 | Modification of thin-film nanocomposite forward osmosis membranes with an antimicrobial carboxymethyl starch-ZnO@MOF-199 nanocomposite for heavy metals and dyes pollutants removal. | Forward osmosis (FO) is increasingly recognized as an eco-friendly and energy-efficient water treatment technique. Nevertheless, traditional thin-film composite (TFC) membranes face challenges such as low water flux, limited selectivity, and vulnerability to fouling. To address these limitations, a multifunctional carb... |
41851975 | Integrating NMR Restraints into Coarse-Grained Simulations: Toward Accurate Conformational Ensembles of Complex Protein Systems. | Structural dynamics play critical roles for the biological activity of protein molecules. Characterizing the inherent conformational landscapes of these macromolecules remains a major experimental and computational challenge, particularly for heterogeneous and transient systems such as intrinsically disordered proteins... |
41851961 | Photochromic Heterometallic Metal-Organic Framework as a Multifunctional Platform for Antibiotic Sensing and Sulfide Photooxidation. | A highly stable heterometallic metal-organic framework (MOF), {[KCd(HL)]·DMF} (H<sub>4</sub>L = 2,5-di(2",4"-dicarboxyphenyl)-1,4-difluoro-benzene), denoted as <b>LCU-118</b> (LCU = Liaocheng University), was successfully synthesized via a solvothermal approach. Aqueous suspensions of <b>LCU-118</b> exhibit remarkable ... |
41851962 | Amorphous MoS<sub>3</sub>-Coated ZnS Heterostructure with Interface-Enhanced Kinetics for Fast and Durable Sodium Storage via Multistep Reaction Pathways. | The growing demand for advanced sodium-ion batteries (SIBs) necessitates the development of high-rate and durable anode materials. However, conventional ZnS-based anodes often suffer from sluggish ion transport kinetics and structural instability during cycling. Herein, a hierarchical ZnS/MoS<sub>3</sub> composite with... |
41851748 | A living therapeutic platform for localized in situ modulation of macrophage pyroptosis ameliorates GVHD while preserving GVL. | <h4>Background</h4>Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality following allogeneic hematopoietic stem cell transplantation, with the gastrointestinal tract being a primary target organ. Dysregulated innate immune activation, particularly within intestinal macrophages, is increasingly r... |
41851736 | Nanoplasmonic optical fiber sensing of SARS-CoV-2 nucleocapsid protein using an aptamer-DNA tetrahedron interface. | Optical fiber sensing carries a number of potential advantages for diagnostics and biomarker detection and monitoring, yet particular challenges persist in linking molecular recognition events to a change in the refractive index. DNA aptamers carry particular advantages as functional surface molecules on optical fibers... |
41851580 | Nanostructured branched Y-DNA promotes antitumor immunity through dual activation of cGAS/STING and TLR9. | Effective activation of innate and adaptive immunity remains a major challenge in cancer immunotherapy. In this study, we aimed to develop an immunostimulatory oligonucleotides for antitumor immunotherapy. We designed branched Y-shaped DNA (Yb-DNA) nanoparticles complexed with a reducible polycationic carrier (RPC-bPEI... |
41851524 | Cofilin-1 is a redox-sensitive guard of the NLRP3 inflammasome. | Mutations in NLRP3 can cause a spectrum of the autoinflammatory cryopyrin-associated periodic syndromes (CAPS). Reactive oxygen species (ROS) have a central role in NLRP3 inflammasome activation. Here we show that cofilin-1, an actin-severing protein, is a negative regulator of the NLRP3 inflammasome. In resting cells,... |
41851464 | The E3 ubiquitin ligase mechanism specifying targeted microRNA degradation. | MicroRNAs (miRNAs) associate with Argonaute (AGO) proteins to form complexes that down-regulate target RNAs, including messenger RNAs from most human genes<sup>1-3</sup>. Within each complex, the miRNA pairs to target RNAs, and AGO provides effector function while also protecting the miRNA from cellular nucleases<sup>2... |
41851446 | The association between GLP-1 receptor agonists and fractures: a nationwide Danish nested case-control study. | To examine whether GLP1-RA is associated with increased fracture risk, we compared 337,648 people with fractures to 675,296 people without fractures. Our adjusted analysis found that people with fractures tended to use GLP1-RA less often than people without fractures. This suggests that GLP1-RA may reduce fracture risk... |
41851282 | Accelerating discovery of MOFs for hydrogen storage via machine learning in energy related applications. | Hydrogen is a promising clean energy carrier, but its low energy density necessitates advanced storage solutions. Metal-Organic Frameworks (MOFs) offer high tunability and porosity for efficient hydrogen adsorption. This work combines Grand Canonical Monte Carlo (GCMC) simulations with machine learning, employing Feed-... |
41851271 | Paraspeckle condensation is controlled via TDP-43 polymerization and linked to neuroprotection. | The paraspeckle is a disease-relevant biomolecular condensate assembled from long non-coding RNA (lncRNA) NEAT1_2 ribonucleoprotein particles. Paraspeckle biogenesis is suppressed in normal tissues, yet it can be rapidly upregulated under stress. Here we demonstrate that a neurodegeneration-linked RNA-binding protein T... |
41851138 | Lysosome-targeting live attenuated influenza vaccines elicit robust and broad immunity in mice. | The lysosome is a cell's endogenous machinery responsible for degrading proteins. Here we describe two lysosome-targeting live attenuated vaccine approaches, LYTAR 1.0 and LYTAR 2.0, by harnessing the lysosome to conditionally degrade viral proteins of influenza virus. LYTAR 1.0 incorporates a conditionally removable l... |
41851094 | Mitochondrial DNA release via VDAC1 in keratinocytes: a key driver of innate immunity and vitiligo pathogenesis. | Vitiligo is an autoimmune depigmenting disorder in which oxidative stress is considered a critical trigger of innate immune activation. Although keratinocytes are increasingly recognized as key contributors to disease progression, the mechanism by which they sense and propagate oxidative stress signals has remained unc... |
41851012 | Pickering emulsions stabilized by menthol/β-CD composite: preparation, characterization, and functional properties. | <h4>Background</h4>This study focuses on the encapsulation of menthol using β-cyclodextrin (β-CD) and the preparation of Pickering emulsions stabilized by the resulting menthol/β-CD composite particles. The research aims to explore the potential of β-CD as a composite carrier for stabilizing such emulsions and to enhan... |
41850897 | Investigation of Novel Antiproliferative Drugs Interaction with mPEG<sub>2k</sub>-PCL<sub>y</sub> Copolymers Using Molecular Dynamics Simulation Approach. | The therapeutic potential of many new drugs is limited by poor aqueous solubility. This work addresses the solubilization improvement of novel fluorescent dihydropyrazole-carbohydrazide derivatives (DPCH), with proven antiproliferative activity against human breast cancer, through encapsulation in three distinct methox... |
41849805 | Supramolecular assembly of cholesterol-conjugated mannan and polyethylenimine into polyplex micelle: a potential biocompatible vaccine adjuvant platform. | The development of potent subunit vaccines requires adjuvant systems capable of eliciting robust cellular (Th1) immunity while maintaining high biocompatibility. Herein, We engineered a novel "safety-by-design" nanoadjuvant platform via the supramolecular co-assembly of cholesteryl-conjugated Mannan (MN-CLS) and choles... |
41849751 | Sustainable bioplastics manufacturing from renewable sources. | Fossil-based material manufacturing has long been linked to the acceleration of climate change through carbon dioxide emissions. In addition to their negative impact on the environment, the depletion of nonrenewable fossil fuels has led to a global demand for sustainable and environmentally friendly alternatives. This ... |
41849689 | A High-Performance and Fully Recyclable Supramolecular Nanofibrous Membrane for Multifunctional Air Filtration. | Developing recyclable, multifunctional air purification materials that minimize environmental impact represents a grand challenge in the pursuit of carbon neutrality. Herein, a multifunctional air filtration membrane is prepared through a thermally induced precursor crystallization (TIPC) process that drives the self-a... |
41849687 | Development of Intervertebral Disc Organoids through Directed Differentiation of Mesenchymal Stem Cells and Hierarchical 3D Printing. | Organoid models of early tissue development have been generated for organs such as the brain, kidney, and intestine. However, the development of intervertebral disc (IVD) organoids has rarely been reported. Here, we have developed a protocol to directly differentiate nucleus pulposus (NP) organoids and annulus fibrosus... |
41849626 | Design and Photophysical Engineering of Functional Organic Luminogens for Precision Cancer Theranostics. | Cancer remains a significant global health challenge, necessitating innovative therapeutic strategies. Functional organic luminogens have emerged as a versatile class of biomaterials for cancer theranostics, enabling the integration of diagnostic imaging and therapeutic intervention within a single molecular or supramo... |
41849606 | Synergistic electronic-topological strategy enables spatiotemporal control of covalent adaptable networks. | Covalent adaptable networks (CANs) hold considerable promise for combining the advantages of thermosets and thermoplastics. However, their use in high-speed melt spinning is restricted by insufficient dynamic bond reactivity at processing temperatures and the mismatch between network rearrangement kinetics and industri... |
41849597 | In situ creation of crystalline channels in ultrathin network polymer membranes for pressurized H<sub>2</sub>/CO<sub>2</sub> separation. | Ordered channels provide an excellent foundation for creating gas-selective pathways in polymeric membranes that endure pressurized and high-temperature conditions. Herein, we present a competitive-reaction interfacial polymerization (CRIP) approach to in situ creation of crystalline channels in ultrathin network polym... |
41849596 | Transforming cisplatin into targeted photothermal chemotherapeutics through the platinum-phosphate coordination within a hyaluronan nanogel. | Cisplatin's (Cis's) antitumor efficacy is limited by dose-dependent toxicity due to nonspecific tissue distribution. While targeted Cis delivery and combination therapies boost therapeutic efficacy, developing multifunctional yet simplified formulations remains challenging. Inspired by the Cis's interaction with DNA, h... |
41849588 | Insights into the structure and evolution of the human SAGA complex by affinity-ligand purification. | Human SAGA is a 20-subunit transcriptional coactivator. Compared with yeast, metazoan SAGA uniquely incorporates a 150-kDa splicing-factor module (SPL), also present in U2 small nuclear ribonucleoprotein (U2snRNP). Metazoan gene duplication further specialized shared TFIID/SAGA subunits into SAGA-specific paralogs (TAF... |
41849448 | Design of Neuronal Supramolecular Scaffolds Integrating Cell Signaling and Electrical Conductivity. | Scaffolds with neuronal bioactivity are important to promote repair of the central and peripheral nervous systems, <i>in vitro</i> neuronal differentiation and maturation for transplantation, and the integration of electronic devices with neural tissues, among others. Previous work in this area includes the incorporati... |
41849397 | Selective fluorination of Fc glycans enhances antibody-mediated effector functions. | Antibody effector functions such as antibody-dependent cellular cytotoxicity (ADCC) and various complement-dependent activities are critically influenced by the structure and composition of Fc N-glycans. Terminal galactosylation is generally associated with enhanced FcγRIIIA binding and C1q recruitment, thereby improvi... |
41849394 | Monkeypox virus protein OPG188 antagonizes cGAS-STING antiviral signaling pathway to mediate immune evasion. | Innate immune evasion is critical for productive viral replication. Activation of the cGAS-STING antiviral signaling pathway and its downstream effector genes plays a pivotal role in restricting viral replication during early DNA virus infection. Through a comprehensive genomic screen of monkeypox virus (MPXV), we iden... |
41849393 | Transiently amplified fluctuations assemble dissipative materials. | Chemical reactions assemble supramolecular materials with finite lifetimes, responsiveness to stimuli, and the capacity to self-heal after perturbation. These dynamic behaviors arise from a reaction cycle that switches a molecule between associating and nonassociating states via two independent pathways, each driven by... |
41849360 | Single-tube two-step RPA-CRISPR/Cas12b platform for detection of Pseudomonas aeruginosa. | Pseudomonas aeruginosa is a ubiquitous opportunistic pathogen of significant clinical and public health concern, necessitating the development of rapid and reliable detection methods. Traditional diagnostic approaches, which rely on culture-dependent techniques and biochemical identification, are often labor-intensive,... |
41849335 | Mutual solubilization of rosiglitazone and ibuprofen: Investigation and mechanistic insight. | <h4>Purpose</h4>We report for the first time that co-dissolved rosiglitazone and ibuprofen mutually enhance their aqueous solubility; the study was designed to quantify this phenomenon and clarify its origin.<h4>Methods</h4>Solubility was measured by HPLC. Fluorescence and FT-IR spectroscopy were used to probe molecula... |
41849332 | Integrated network pharmacology and comprehensive bioinformatics analysis to identify the mechanisms and molecular targets of ketamine in ischemic stroke-depression comorbidity. | Comorbid depression following ischemic stroke is a debilitating condition with complex pathophysiology. Although ketamine demonstrates rapid antidepressant effects, its molecular mechanisms in the context of this comorbidity are poorly understood. We employed a network pharmacology approach to hypothesize potential mol... |
41849279 | Computational design of functional random heteropolymers through atomistic simulations. | Random heteropolymers (RHPs) are emerging single-chain nanoparticles with great potential in protein mimicry, yet a systematic understanding of how chemical composition and monomer structures govern their structure, dynamics, and hydration remains limited. Using atomistic molecular dynamics simulations, we examine how ... |
41849182 | Applying multimodal dendrimers for prostate cancer theranostics. | Dendrimers represent a unique category of polymeric macromolecules characterized by a well-defined architecture that begins with a central core, expands through regularly repeating branching units, and terminates in a dense array of surface functional groups. Unlike conventional linear or random polymers, dendrimers ex... |
41848883 | Nanoformulations of essential oils for the treatment of fungal diseases, with a focus on dermatophytes. | Fungal infections, particularly those caused by dermatophytes, affect over 25% of the world's population and pose a significant public health risk to both humans and animals. Conventional antifungal treatments face substantial challenges like drug resistance, adverse effects, and require long-term systemic medications.... |
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