id stringlengths 4 8 | title stringlengths 1 642 | abstract stringlengths 50 17.9k |
|---|---|---|
41853205 | Sustainable catalytic conversion of ethanol: catalyst design and modification strategies for dehydration and petrochemical applications. | Ethanol has emerged as a promising renewable feedstock for chemicals and sustainable fuel production. Its conversion into ethylene, diethyl ether, and higher-value chemicals through dehydration over catalysts relies on carefully designed catalysts to enhance activity, selectivity, and stability. This review critically ... |
41853202 | Smart nanosystems for disease-resistant potatoes: a new Frontier in nanobiotechnology. | Microbial diseases in potato crops pose significant threats to production quality and crop protection. Yield losses due to these diseases are unsustainable for a world that is increasingly reliant on potato-based diets. Conventional management strategies, including chemical and biological controls, have been employed, ... |
41853201 | Influence of PESU/PVP based nanofibrous separators on the properties of LNMO cathode based Li-ion batteries. | The properties of selected separators and their influence on the electrochemical properties of a high-voltage cathode material are investigated in this paper. The LiCr<sub>0.1</sub>Ni<sub>0.4</sub>Mn<sub>1.5</sub>O<sub>4</sub> material synthesized by a solid-state reaction was chosen as the testing material. Four kinds... |
41853199 | Smart adsorbent frameworks enabling high-efficiency pharmaceutical degradation <i>via</i> adsorption. | Pharmaceutical residues are increasingly detected in aquatic systems and present ecological and human health concerns due to their biological activity, structural complexity, and limited biodegradability. Poor removal <i>via</i> conventional wastewater treatment processes drives the development of smart adsorbents that... |
41853193 | Catechol functionalized polyguluronate enriched sodium alginate wetspun fibers with immobilized platelet lysate for diabetic wound healing. | The development of advanced wound dressings with multifunctional properties is crucial for accelerating healing in diabetic wounds. Platelet lysate contains many biologically active substances, which have tremendous clinical benefits in treating diabetic wounds. However, its clinical use and therapeutic efficacy are se... |
41853192 | Marigold-flower-like MoS<sub>2</sub> nanosheet assemblies for enhanced alkaline hydrogen evolution. | The development of efficient, cost-effective, and noble-metal-free electrocatalysts is critical for sustainable hydrogen production <i>via</i> water splitting. Herein, hierarchical MoS<sub>2</sub> nanosheets were synthesized through a facile hydrothermal method, producing a marigold flower-like morphology with abundant... |
41853133 | Orchestrating Chemo-Ferroptosis via Nonthermal Magnetocatalysis: A Cascade Amplification Paradigm for Breast Cancer Therapy. | Conventional tumor microenvironment-responsive nanotherapies are limited by their passive dependence on endogenous triggers, often resulting in suboptimal therapeutic efficacy due to tumor heterogeneity. Furthermore, monotherapy frequently induces drug resistance, highlighting the need for synergistic strategies target... |
41852696 | Nitrogen-doped carbon quantum dots as fluorescent sensor for doxorubicin and chlortetracycline: experimental and DFT insights. | The accurate and rapid detection of clinically vital but potentially toxic pharmaceutical residues, such as the anticancer agent Doxorubicin (DOX) and the broad-spectrum antibiotic Chlortetracycline (CTC), is essential for therapeutic drug monitoring and environmental safety. This work presents the development of a nov... |
41852506 | Encapsulation of carbon dots in medicinal chemistry: a comprehensive review of recent advances and applications. | Carbon dots (CDs) have emerged as highly promising nanomaterials in medicinal chemistry due to their unique optical properties, excellent biocompatibility, and facile surface functionalization. However, their clinical translation is often hindered by limitations such as colloidal instability, nonspecific biodistributio... |
41852507 | Tuning the electrochemical performance of a copper-based 2D rectangular layered metal organic framework by incorporating reduced graphene oxide and polyaniline. | To meet the challenge of developing efficient energy storage devices, metal organic frameworks (MOFs) with intrinsic properties have emerged as promising candidates. The conductivity and stability of the extended 1D π-<i>d</i> and π-π stacking in a 2D MOF can be further enhanced by fabricating its composite with conduc... |
41850428 | Smart nano-assembly from traditional Chinese medicine: Manganese-enhanced polysaccharide platform for orchestrated cancer chemo-immunotherapy. | <h4>Introduction</h4>The limitations of conventional cancer therapies have driven the development of precise, low-toxicity strategies. Natural products with bioactivity and self-assembly potential offer a basis for designing multifunctional nanomedicines combining chemotherapy, chemodynamic therapy (CDT), and immunothe... |
41846294 | Processing-Structure-Property Relationships in Poly(vinylidene fluoride) Composites Containing Metal Organic Frameworks and Ionic Liquids: A Roadmap for Application-Driven Design. | Composites including metal-organic frameworks (MOFs) loaded with ionic liquids (ILs) are materials that are currently under extensive study in the catalysis, adsorption, and electrochemistry fields, as this approach has proven to be effective in enhancing the overall physicochemical and functional properties of the com... |
41844839 | MOF-mediated H4K16ac is critical for blastocyst formation in sheep by shaping promoter accessibility and transcription. | Extending culture to blastocysts in vitro enhances embryo selection efficiency and implantation success in mammals, yet the epigenetic mechanisms underlying blastocyst formation remain unclear. Here, we investigate the role of histone acetyltransferase MOF-mediated H4K16ac during sheep blastocyst formation. We find dyn... |
41844825 | Novel soluble bazedoxifene formulation gains antiproliferative and migrastatic effect in squamous cell carcinoma cells. | The IL-6 signalling pathway plays a significant role in the progression and development of squamous cell carcinoma (SCC). Bazedoxifene is a potent inhibitor of IL-6R; however, its efficacy is limited by its low solubility in water (0.54 mg/mL). In contrast, BAZE-X1, a formulation of bazedoxifene using sulfobutylether-β... |
41844666 | Permeable nanoreactor eye drop for enzymatic cascade-mediated treatment for acute retinal injury model mimicking geographic atrophy. | Geographic atrophy (GA), the most prevalent form of age-related macular degeneration (AMD), remains clinically challenging due to its complex pathogenesis. Using an acute retinal injury model that mimics GA pathology (oxidative stress-induced retinal apoptosis), we identify enzymatic cascade restoration as a promising ... |
41844583 | Unlocking large-area free-standing MOF-glasses for molecular sieving gas separation membranes. | Membranes from MOF glasses hold significant promise for gas separations due to the absence of grain boundary diffusion, liquid processibility, and tunability. The inherent high viscosity of MOF melts renders them prone to cracking and further handling, and their propensity to densify at high temperatures and long time ... |
41844288 | Total Synthesis of the SJG-2 Glycan: General Strategies for Constructing Sterically Congested Sialylated Glycans. | Gangliosides are a diverse class of glycosphingolipids whose sialylated glycans regulate processes ranging from neuronal repair to immune responses. Among them, SJG-2, an echinoderm-derived ganglioside with potent neuroregenerative activity, stands out for its rare and highly branched trisialylated glycan motif. The un... |
41844274 | Normalizing Covalent Potency for Electrophilicity with Ligand Reactivity Efficiency. | Covalent modalities represent an important component of the modern medicinal chemist's toolbox for pursuing challenging targets in drug discovery. By taking a "covalent-first" approach to identifying druggable pockets on challenging-to-drug targets, we and others have expanded accessible target space and driven fragmen... |
41844277 | Dectin-1 epigenetic reprogramming rescues senescent-like Treg function in allergic asthma. | Allergic asthma is characterized by immune dysregulation, and deficiencies in regulatory T-cell (Treg) function are a hallmark of the disease. However, mechanisms of Treg impairment for their therapeutic correction remain poorly defined. The results showed that patient Tregs exhibited a senescent phenotype, including s... |
41844170 | Manufacturing Silk Fibroin Hollow Nanoyarns as Fundamental Units for Advanced Medical Textiles. | Nature-inspired designs aim to replicate the hierarchical structure observed in native tissues. Fibers serve as fundamental modular units, enabling the fabrication of complex architectures for the engineering of medical textiles and tissue equivalents. However, synthetic yarns lack inherent biological cues to support t... |
41843830 | Evidence of Two-Dimensional Porous Ice at Room Temperature. | The phase behavior of water and ices is remarkably complex because of the high flexibility of their underlying hydrogen-bonding networks. Even for two-dimensional (2D) ice, rich forms of monolayer and bilayer ice phases have been observed in molecular dynamics (MD) simulations, including, among many others, flat-square... |
41843676 | Reprogrammed SimCells for antimicrobial therapy. | Antimicrobial resistance (AMR) is a critical global health challenge. In this study, we developed a platform based on chromosome-free and nonreplicating simple cells (SimCells, size 1 to 2 µm) and mini-SimCells (size 100 to 400 nm) for targeted pathogen elimination. Engineered with surface-displayed nanobodies, SimCell... |
41843670 | Gustatory sensing by ovipositor drives maternal avoidance of hesperidin to benefit the offspring in a major agricultural fly pest. | Females of the oriental fruit fly (<i>Bactrocera dorsalis</i>) disproportionately oviposit in unripe fruits, despite their lower nutritional value compared to ripe fruits, but the sensory cues driving such counterintuitive site selection have not been determined. Here, using an oriental fruit fly-mango interaction syst... |
41843625 | LL-37 selectively targets Plasmodium-infected erythrocytes and exhibits antimalarial activity. | Malaria control is challenged by the emergence of resistance to virtually all antimalarial drugs, from the frontline artemisinin to other classes, highlighting the critical need for new therapies. This study demonstrates that the human antimicrobial peptide LL-37 exhibits antiplasmodial activity against both drug-sensi... |
41843581 | Probing Induced-Fit Acetylene Adsorption and Separation in a Flexible Ultramicroporous Framework by Multinuclear SSNMR Spectroscopy: Insights Beyond Crystallography. | This study investigates the molecular-level-induced-fit adsorption of acetylene (C<sub>2</sub>H<sub>2</sub>) and carbon dioxide (CO<sub>2</sub>) in sql-SIFSIX-bpe-Zn, a flexible, anion-pillared ultramicroporous metal-organic framework (MOF). Sql-SIFSIX-bpe-Zn undergoes distinct pressure-dependent phase transitions, ena... |
41843571 | Pandemic-driven immune imprinting accelerates evolution of human coronavirus OC43. | Global pandemic interventions have reshaped host-virus dynamics, potentially altering the evolution of endemic pathogens. Here, we report accelerated genomic evolution of human coronavirus OC43 (HCoV-OC43)-a close relative of pandemic-associated coronaviruses-following recent worldwide epidemiological shifts. Bayesian ... |
41843473 | Supramolecular hydrogen-bonded chiral networks enable blue circularly polarized emission from polymeric carbon quantum dots. | All-organic circularly polarized luminescence (CPL) emitters acting as intrinsic liquid polarizers provide a promising route to reduce optical crosstalk and enhance spatial resolution in displays by directly emitting circularly polarized light, thereby eliminating external polarizers and minimizing energy loss. Herein,... |
41843470 | Hydroxylated Bimetallic MOF Dual-Mode Biosensor: A Platform for Rapid Screening and Accurate Quantitative Detection of Free Bilirubin. | Elevated levels of free bilirubin (f-Bil) in the blood can cause neonatal brain damage, making the development of rapid and accurate detection methods critical for diagnosing neonatal jaundice. This study targeted the structural characteristics of f-Bil and synthesized a hydroxylated bimetallic MOF (FeCu-MOF-OH) with h... |
41843276 | Developmental stage-specific disruption of iron allocation by a ZmYSL2 mutation in maize. | <h4>Main conclusion</h4>The ZmYSL2 mutation causes abnormal iron distribution in tissues of maize o213 mutants, disrupting iron transport during the V9/12D developmental stage while simultaneously reducing iron transport efficiency. Iron (Fe) is an essential nutrient for plants. This study demonstrates that the ZmYSL2 ... |
41843026 | Cu-based metal-organic frameworks: synthesis, biomedical applications, and beyond. | Copper-based metal organic frameworks (Cu-MOFs) represent a highly versatile family of porous crystalline materials valued for their tunable structures, redox-active Cu centers, and inherent biodegradability, which collectively increase their therapeutic and technological potential. This review provides an integrated o... |
41843006 | Selective detection of arsenite in alkaline media using a yolk-shell (Ce/Fe) terephthalate/organoclay framework stripping voltammetric sensor. | To address environmental and health challenges while promoting sustainable clean water and soil, a highly sensitive graphite paste sensor incorporating a nanocomposite material has been developed. This sensor utilizes a yolk-shell (Ce/Fe) terephthalate (Ce/Fe-Tph.) framework intercalated with organoclay (MMt<sub>D2000<... |
41843005 | σ-Hole mechanism in chalcogen-bond catalyzed aza-Diels-Alder reaction. | <h4>Context</h4>Chalcogen bonding (ChB) catalysis has emerged as a promising non-covalent strategy for activating substrates in cycloaddition reactions, yet its mechanistic details in aza‑Diels-Alder transformations remain underexplored. This study systematically investigates the catalytic role of a homologous series o... |
41842850 | Self-Avoiding Gamma Peptide Nucleic Acids for Selective Targeting of RNA Secondary Structures. | RNA molecules play essential roles in all aspects of cellular function, but their complex secondary and tertiary structures pose significant challenges for selective targeting. Traditional antisense strategies often avoid these structured regions, focused instead on unstructured sequences. In this study, we present an ... |
41841742 | Nondestructive tracking of viral infections by viral protein-initiated fluorescent sensors. | Real-time tracking of viral infection processes is critical for elucidating the pathogenic mechanisms and therapeutic targets. A more detailed understanding of viral movement in the extracellular environment <i>in vivo</i> as well as in extraplasmic space requires the development of a tool capable of stable fluorescenc... |
41841732 | Targeting MCR-3 and membrane biosynthesis: mechanistic insights into pterostilbene-colistin synergy. | Colistin is a crucial antibiotic for treating infections caused by multidrug-resistant Enterobacterales. However, the emergence of plasmid-mediated <i>mcr</i> genes has significantly compromised their clinical efficacy. Natural adjuvants, such as pterostilbene, offer a promising strategy to restore antibiotic efficacy ... |
41841724 | Evaluation of serine protein kinase HPrK as an antibacterial target in gram-positive bacteria and mycoplasmas. | Antimicrobial resistance (AMR) poses a serious threat to global public health. To tackle this challenge, identifying novel effective antibacterial targets and antibiotics is crucial. The serine kinase HPrK, widely present in gram-positive bacteria and mycoplasmas, primarily regulates carbon metabolism and virulence fac... |
41841637 | MOF Ceramic-Like Membrane With High Proton Conduction and Tunable Transparency. | The industrial deployment of metal-organic frameworks (MOFs) is hindered by their particulate morphology, while the fabrication of macroscopic architectures-particularly continuous membranes remain a major challenge. Traditional approaches, such as matrix blending, vitrification, or substrate-supported deposition, ofte... |
41841623 | Pillar[6]arene Assemblies With Continuous Hydrophobic Grooves for Capture of π-Conjugated Molecules. | Preorganization is a central principle in supramolecular chemistry, enabling selective molecular recognition through confined macrocyclic cavities. Extending this concept from single macrocycles to their assemblies could enable recognition beyond single-cavity limits. However, it remains unclear how molecular assemblie... |
41841473 | Stabilizing Silver Single-Atom Site via A Pore-Confined Triphenylphosphine for CO<sub>2</sub> Conversion With High Substrate-Specificity. | Ensuring the dispersion and anti-aggregation of single-atom sites under catalytic conditions remains a critical challenge in heterogeneous catalysis. Here, we report a dual-confinement strategy for constructing a metal-organic framework (MOF) based catalyst, MEC-88, by spatially confining triphenylphosphine (PPh<sub>3<... |
41841405 | Subnanometric Platinum-Germanium Clusters for Efficient Propane Dehydrogenation Catalysis. | Propane dehydrogenation has been a key technology with great industrial promise for meeting the growing global demand for propylene. Although much effort has been devoted to developing ideal catalysts that demonstrate high catalytic activity, selectivity, and durability at the same time, there have been few reports on ... |
41841396 | Near-Infrared-Light-Driven Photochemistry and Photocatalysis: Mechanisms, Recent Applications, and Opportunities in Organic Synthesis and Biology. | Near-infrared (NIR) photochemistry and photocatalysis have emerged as powerful extensions of analogous visible-light methods, offering unique advantages, such as deeper penetration through opaque media, minimal background absorption, reduced scattering, more selective photon absorption, and enhanced safety profiles. Th... |
41841367 | Chiral Borophosphate-Catalyzed Kinetic Resolution of Diaryl Tertiary Alcohols through Dehydration. | Optically active diaryl tertiary alcohols are key moieties in natural products and pharmaceuticals, making efficient asymmetric synthesis highly desirable. Catalytic kinetic resolution is a practical strategy for accessing such chiral compounds, yet dehydration-based kinetic resolution methods remain scarce. Herein, we... |
41841354 | Mixed-Lanthanide Metal-Organic Frameworks for Near-Infrared-I Bioimaging and Near-Infrared-III Four-Photon Upconversion. | Lanthanide-based metal-organic frameworks (Ln-MOFs) provide a structurally precise platform for upconversion luminescence engineering, yet practical applications are limited by insufficient structural stability, restricted color tunability, and the lack of excitation in the NIR-III window. Here, we report a MOF incorpo... |
41841329 | Multi-targeted pyrazole scaffolds: synthesis, mechanistic insights, and therapeutic potential in anticancer, antioxidant, and anti-inflammatory applications. | Pyrazole derivatives are a class of heterocyclic compounds known to have broad pharmacological effects. This study aimed to synthesize and characterize a new series of pyrazole derivatives and investigate their effects on a series of <i>in vitro</i> assays. Five synthesized compounds were confirmed structurally using s... |
41841302 | Unlocking Efficient Spontaneous Deracemization: A MOF-Mediated Heterogeneous System Overcomes Catalytic Incompatibility in Cocrystallization. | Cocrystallization-induced deracemization is a powerful route to enantiopure pharmaceuticals, yet is hindered by detrimental interactions between homogeneous catalysts and chiral components. Herein, we report a novel heterogeneous catalysis strategy using metal-organic frameworks (MOFs) to overcome this compatibility ch... |
41841312 | Revealing the Trade-Off between Catalytic Activity and Mass Transport in Fuel Cells: Perspectives from Solvent and Ionomer Coverage State. | In response to the conflicting challenges between enhancing polarization performance and optimizing platinum catalyst utilization in proton exchange membrane fuel cells (PEMFCs), this study systematically deciphers the formation mechanism of triple-phase interfaces (TPIs) in catalytic layers (CLs) and develops a multid... |
41841309 | Molecular Tuning Nanoarchitectonics of Azobenzene-Based Pliers Directs Chiral Preference and Reversible Helicity Inversion in Coordinated Molecular Rotors. | Controllable chirality in mechanically locked or coordinated molecules is essential for the development of functional molecular machines. Here, we systematically investigate how geometric tuning of azobenzene-based pliers governs chiral induction and dynamic helicity in coordinated molecular rotors. Four plier derivati... |
41841248 | Magnetic Field-Responsive Smart bioMOF Composites Based on Bi(III)-Ellagate SU-101. | Bioderived metal-organic frameworks (bioMOFs) have attracted interest as functional materials for medical-related applications due to their biocompatibility and structural tunability. However, the integration of external stimulus responsiveness into bioMOF architectures while preserving the framework integrity remains ... |
41841213 | Cellular Snowballing: Cell Adhesion and Migration Drive the Self-Assembly of Cell-Microgel Biohybrid Spheroids. | Creating three-dimensional (3D) tissue models using cell spheroids that recapitulate the complicated structures and functions of human tissues is essential for advancing new approach methodologies used in drug testing/screening, disease modeling, and regenerative medicine. However, cell spheroids often have dense cellu... |
41841212 | Challenging the Macrocycle Paradigm: Four-Arm, High-Denticity Acyclic Chelators for Radiopharmaceuticals Incorporating Actinium and Lanthanides. | As an alternative to macrocyclic chelators, a family of high-denticity, acyclic chelating agents based on picolinate arms has been devised with the aim of finding versatile chelating agents for <sup>225</sup>Ac, <sup>161</sup>Tb, and <sup>177</sup>Lu. This family comprises six symmetrical four-arm decadentate chelators... |
41841188 | Guest-Enhanced Charge Separation in Porphyrin-Based Double-Cavity Metallacages for Visible-Light-Driven H<sub>2</sub>O<sub>2</sub> Production. | Hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) is a versatile and green oxidant with wide industrial applications, yet its large-scale production still relies on the energy-intensive anthraquinone process. Photocatalytic synthesis of H<sub>2</sub>O<sub>2</sub> under visible light offers a sustainable alternative but re... |
41840983 | Photoinduced Formation of Heterobiradical Species in Crystalline Uranyl-Organic Frameworks Incorporating Cucurbit[8]uril-Viologen [3]Pseudorotaxane. | Uranyl (UO<sub>2</sub><sup>2+</sup>) compounds are valued for their unique ligand-to-metal charge transfer (LMCT) states, yet electron transfer (ET) mechanisms within actinide-supramolecular hybrids remain poorly understood. In this study, three photochromic uranyl compounds of cucurbit[8]uril-viologen [3]pseudorotaxan... |
41840999 | Organophosphonate Ligation Approach for the Controlled Assembly of Gigantic Polyoxometalate Clusters. | The controlled assembly of gigantic polyoxometalate (POM) clusters remains one of the most formidable challenges in molecular self-assembly, as it is highly dependent on delicate synthesis parameters that can yield a wide variety of products. In this study, we report the synthesis of a series of unprecedented wheel-sha... |
41773313 | Unraveling the role of Co-O-Ni motifs in MOF-derived CoNi-LDH for the enhanced oxygen evolution reaction. | The electrocatalytic oxygen evolution reaction (OER) is a critical bottleneck in water splitting due to its sluggish kinetics. Herein, we developed a MOF-derived CoNi-LDH catalyst (MDCoNi-LDH) based on an <i>in situ</i> etching strategy. We demonstrate that the hierarchical architecture facilitates mass transfer, while... |
41773291 | A novel directed evolution platform for engineering chemically gated protein switches. | Chemically gated protein switches have broad applications in regulating cellular activities. In this study, we introduce DuoSelect, a yeast surface selection platform for selecting protein switches based on signal-to-background ratios by combining both negative and positive selections in a single round of sorting. We d... |
41770701 | Chalcogen bond-driven self-assembly of a 4-<i>tert</i>-butylcalix[4]arene-ebselen conjugate. | The structural and self-assembling traits of a molecular system are intricately linked to the complex interplay of weak non-covalent interactions that exist within the molecule (intramolecular) and with other molecules (intermolecular). In this work, we report the interplay of intra- and intermolecular chalcogen bonds ... |
41757994 | Dual-pathway sensing in Ti-MOFs for selective VOC discrimination by SERS. | We present a Ti-MOF-based SERS sensing platform for the highly sensitive and selective detection of VOCs, featuring two distinct analyte-specific mechanisms: confinement effects <i>vs.</i> π-interactions. |
41757763 | Cyclic peptide-based shear-thinning and self-healing hydrogels as injectable nanotherapeutics. | An injectable cyclic peptide-based hydrogel (cpGel) governed by supramolecular interactions between cyclic octapeptide nanofibers and LAPONITE® was developed. We demonstrated its excellent injectability, elasticity, and self-healing properties through rheological analyses. Further, we showed that cpGel is cytocompatibl... |
41739638 | Hyper-crosslinked polymeric ionic liquid (HCPIL)-based chainmail adsorbents for highly efficient gaseous toluene capture under high humidity. | A kind of hydrophobic chainmail adsorbent, Cu-BTC@HCPIL (water contact angle up to 109.6°), was developed through ionic liquid-based hyper-crosslinked polymer surface engineering of a metal-organic framework (MOF). Under 80% relative humidity (RH = 80%), due to the presence of a hierarchical pore structure and hydropho... |
41738981 | Copper-based metal-organic framework for sensitive sensing of Cr<sub>2</sub>O<sub>7</sub><sup>2-</sup> in aqueous solution. | The dichromate ion (Cr<sub>2</sub>O<sub>7</sub><sup>2-</sup>) is a highly toxic and carcinogenic pollutant in wastewater, which requires accurate and rapid monitoring techniques. In this study, a water-stable copper-based metal-organic framework (Cu-OCH<sub>3</sub> MOF) is developed as a fluorescent sensor for detectin... |
41686143 | Molecular recognition meets microcontroller: calixarene-based fluorescent sensors for selective detection of 2-nitrobenzaldehyde. | Fluorescent supramolecular materials have emerged as versatile tools for detecting nitroaromatic compounds (NACs), which are key components of explosives and persistent environmental pollutants. Among these analytes, 2-nitrobenzaldehyde (2-NBZ) warrants particular attention due to its high toxicity, environmental persi... |
41575182 | Cocrystallisation with carbon. | While carbon is ubiquitous across organic synthesis and materials chemistry, in supramolecular chemistry the role of carbon as a target for the formation of directional interactions, such as hydrogen or halogen bonds, is less known and developed in comparison to nitrogen or oxygen. Here we provide a brief review of the... |
41562208 | Combination prostate cancer therapy <i>via</i> CuTCPP-MOF-mediated chemodynamic and photodynamic effects. | Prostate cancer remains one of the most common malignant tumors among men worldwide, and treatment options are limited in the advanced stage. To address this challenge, we have developed a pH-responsive copper porphyrin metal-organic framework (CuTCPP-MOF), which integrates photodynamic therapy (PDT) and chemodynamic t... |
41556093 | A Pt(IV) prodrug-gating MOF incorporating copper peroxide and ruthenium complex for NIR-mediated synergistic anticancer therapy. | The development of efficient and multifunctional nanosystems is crucial for enhancing anticancer therapy. The incorporation of therapeutic agents in nanocarriers often results in premature drug release, leading to unsatisfactory therapeutic effects. To overcome these challenges, a nanosystem, MOF@Cu/Ru/Pt (MOF = metal-... |
41939409 | Biosensing of Steroid Hormones with 3D Zinc Oxide Tetrapods. | Accurate monitoring of stress hormones is essential for understanding physiological responses and optimizing human performance. Selective and precise detection of these biomarkers is particularly important for evaluating stress levels in high-demand environments. Herein, we report a multimodal sensor based on zinc oxid... |
41939403 | Roles of π‑Conjugation and Intermolecular Interactions in Molecular Raman, Fluorescence, and Lifetime Spectroscopy. | Understanding the relationship between molecular structure at the microscale and spectral behavior is essential for designing functional materials. Here, we report how the chemical structure, π-conjugation, and intermolecular interactions jointly modulate Raman spectroscopy, fluorescence, and excited-state lifetimes of... |
41939365 | Hydrothermally Synthesized Mn<sub>2</sub>V<sub>2</sub>O<sub>7</sub> Nanopebble-Decorated ZIF-67: A Promising Cathode Material for Energy Storage Applications. | Metal-organic framework (MOF) based electrodes typically are very good at holding energy and have low electrical conductivity limitations. Studies on redox additive electrolytes (RAEs) have been explored to further enhance the electrochemical characteristics and scale up. Additionally, additives make a Faradaic charge ... |
41939343 | Silicon Carbide Derived from Chicken Manure for Highly Efficient Photocatalytic and Electrocatalytic Sensing Properties. | Silicon carbide (SiC) with a rhombohedral structure and irregular microscale particles was prepared using chicken manure and silica sol and characterized by various techniques. The optimal preparation parameters for SiC from chicken manure (CM-SiC) are determined by controlling the reaction temperature, time, and In co... |
41939334 | A Selective Separation Method to Determine Radiostrontium in Water Samples Based on the Chelation of Potential Interferences with EDTA. | A new rapid, safe, and cost-effective Sr separation method to determine <sup>89</sup>Sr and <sup>90</sup>Sr in water samples has been developed. First, Ba and Ra were precipitated with chromate at pH 6-7 and Sr was precipitated with sulfate. Then, the potential interferences in the SrSO<sub>4</sub> salt were chelated a... |
41939307 | 3D-Bioprinted Hydrogels Based on Calcium Alginate and Turmeric (<i>Curcuma longa</i> L.): Comprehensive Structural, Functional, and Biological Evaluation for Advanced Wound Healing Applications. | Sodium alginate polysaccharide is widely used for its ability to form hydrogels in the presence of calcium ions, showing excellent liquid retention properties. At the same time, <i>Curcuma longa</i> L. (CR) is known for its anti-inflammatory, antioxidant, and antimicrobial activities. Considering these characteristics,... |
41939305 | Mechanism of Hydrolytic Instability of ZIF‑8 in Aqueous and Buffered Media: Implications on Drug Delivery Applications. | Despite widespread assumptions of ZIF-8 stability in aqueous media, we demonstrate that the apparent endurance of ZIF-8 is largely misconceived as thermodynamic stability rather than correctly ascribed as kinetic stability under a certain experimental setup. In unbuffered solutions, the rapid release of zinc and 2-meth... |
41937930 | Exploring the Competition between Halogen Bonding and CH Hydrogen Bonding in Bromoarenes Using an Aryldiyne Template. | Hydrogens connected to benzene rings functionalized with electron-withdrawing groups are found to provide attractions with electron donors that are competitive with the halogen bond attraction to bromines on the same rings. An aryldiyne bridge that adequately templates this CH hydrogen bonding, along with the competing... |
41918886 | Advances in protein ubiquitination modification and immune evasion of breast cancer. | Protein ubiquitination is one type of post-translational modification that can alter many properties of the protein-stability, activity, subcellular location, binding affinity for other proteins, etc. It has been involved in almost all life activities, including immune response regulation, DNA damage repair, cell cycle... |
41918876 | Characterization of YhcN in stress adaptation and its complex transcriptional regulation by SlyA in <i>Yersinia pestis</i>. | SlyA, a key transcriptional regulator in <i>Yersinia pestis</i>, is involved in stress adaptation and virulence, yet its regulatory mechanisms remain poorly understood. Here, we investigate the role of the conserved hypothetical protein YhcN and its regulation by SlyA in <i>Y. pestis</i>. We demonstrate that deletion o... |
41918713 | Recent advances in the stereoselective synthesis of distal biaxially chiral molecules. | Molecules bearing 1,3-dual axial and more distal axial chiralities are widely applied in chiral ligands, natural products, and anticancer agents, with their unique spatial configurations endowing them with distinctive functions and values. Although significant progress has been made in the asymmetric synthesis of dista... |
41901437 | The Overlooked Impact of Botanical Pesticides on Non-Target Organisms. | To better understand how botanical products affect non-target organisms, the present review focuses on the toxicity of botanical pesticides to organisms other than targeted pests, to trace a panorama on the future of sustainable agricultural models worldwide, considering the importance of ecotoxicological studies in th... |
41901434 | Genome-Wide Identification of the <i>LcGA2ox</i> Gene Family in Litchi (<i>Litchi chinensis</i> Sonn.) and Its Functional Analysis in Gibberellin Metabolism and Reproductive Development. | Gibberellin 2-oxidase (GA2ox) is instrumental in gibberellin (GA) catabolism and the modulation of plant growth. In this investigation, nine <i>LcGA2ox</i> genes (<i>LcGA2ox1</i>-<i>LcGA2ox9</i>) were identified within the litchi (<i>Litchi chinensis</i> Sonn.) genome. Bioinformatics analyses revealed that the proteins... |
41901335 | A Novel Dual URAT1/GLUT9 Inhibitor Reduces Hyperuricemia by Enhancing Uric Acid Excretion and Attenuating Renal Fibrosis. | <b>Background</b>: Hyperuricemia (HUA) is a metabolic disorder that severely threatens human health. Chronic uric acid (UA) overload promotes the progression of tubulointerstitial fibrosis (TIF), leading to impaired UA excretion. Our previous studies identified HIPK2 inhibitor XRF-1021, which exhibits robust anti-TIF a... |
41900646 | Exploring Thermally Conductive and Form-Stable Phase Change Composites: A Review of Recent Advances and Thermal Energy Applications. | The global population explosion and accelerated industrialization have led to an increasing shortage of fossil fuels and environmental contamination, underscoring the urgent need to develop innovative energy storage technologies to improve energy utilization efficiency. As pivotal components in thermal energy storage (... |
41900090 | GNN-MA: Soft Molecular Alignment with Cross-Graph Attention for Ligand-Based Virtual Screening. | Ligand-based virtual screening (LBVS) seeks strong early enrichment when searching ultra-large libraries, but practical screening often relies on 1D/2D descriptions while 3D information is expensive and uncertain due to conformer generation and alignment. We propose GNN-MA, a retrieval-style pairwise scoring model for ... |
41898570 | Nitrochalcones: Pharmacological Activities and Therapeutic Potential. | Chalcones are compounds containing an α,β-unsaturated carbonyl group that have been studied due to their structural simplicity, ease of synthesis, and broad spectrum of biological activities. Within this family, nitrochalcones have gained relevance due to the influence of the nitro group (-NO<sub>2</sub>) on the modula... |
41898562 | From Polyphenols to β-Lactamases: Multitarget Strategies to Defeat Severe Resistance. | Antimicrobial resistance (AMR) is one of the most pressing global public health challenges, compromising the effectiveness of standard antibiotic therapies and increasing morbidity, mortality, and healthcare costs. The scarcity of new antibiotics has driven research into alternative strategies to restore or enhance the... |
41898556 | Biosensor-Based Detection of Calprotectin and Lactoferrin as Neutrophil-Derived Markers of Inflammatory Bowel Diseases: From Molecular Pathophysiology to Point-of-Care Platforms. | Inflammatory bowel diseases (IBD) are chronic, relapsing, immune-mediated disorders that require regular and preferably noninvasive monitoring of inflammatory activity. Fecal biomarkers of neutrophilic inflammation, namely calprotectin and lactoferrin, therefore represent key analytical targets for diagnosis and longit... |
41898558 | Integration of Network Pharmacology and Molecular Docking Together with an In Vitro Nitric Oxide Inhibition for the Insight for Antipyretic Effects of Benjalokawichian, the Thai Traditional Polyherbal Remedy. | Benjalokawichian (BLW) is a classic antipyretic polyherbal remedy used in Thai traditional medicine (TTM) to reduce toxic fever (TF). This study aimed to shed light on the mechanisms of action and identify bioactive components of BLW responsible for TF treatment. The methods that combine network pharmacology, molecular... |
41898328 | Mitochondrial Dysfunction in the Inflammatory Process of Neurodegenerative Diseases. | Neurodegenerative diseases share a mitochondrial-immune axis in which impaired oxidative phosphorylation reshapes neuronal metabolism and drives chronic inflammation. Complex I play a redox gatekeeper role at the coenzyme Q (CoQ) junction: catalytic defects, misassembly, or reverse electron transport over-reduce the Co... |
41898323 | Peptides and Amino Acids in Drug Development: Where We Stand and Where We Must Go. | Peptides are now a key part of modern drug development, transforming the industry at an extraordinary rate [...]. |
41897769 | Encapsulation of Bee Pollen Phenolics with β-Cyclodextrin: Effects on Antioxidant Activity, Antimicrobial Properties, and Digestive Stability. | Bee pollen is a natural product with multifunctional properties, containing abundant bioactive compounds, especially phenolic acids and flavonoids, which are largely responsible for its antioxidant and antimicrobial activities. In this study, the bioactive composition, antioxidant capacity, encapsulation efficiency, an... |
41897752 | Development of a Layer-by-Layer Zein/CMCS Microcapsule Platform for Bacteriophage Delivery: A Proof-of-Concept Study Using a Model Phage in Sea Bass. | Bacteriophages (phages) offer a targeted biocontrol solution, but their direct application is hampered by environmental instability. To address this, we developed a novel, food-grade microcapsule system for phage delivery using layer-by-layer (LbL) self-assembly of zein and carboxymethyl chitosan (CMCS). Lytic phages t... |
41893237 | Green-Synthesized Nanomaterials for Catalytic Reduction of para-Nitrophenol and Methylene Blue: Recent Advances and Perspectives. | Nitrophenol (NP) and methylene blue (MB) are considered among the most hazardous organic contaminants frequently released from pharmaceutical, textile, and paper industries, posing significant risks to both human health and the environment. The conventional treatment involves adsorption, oxidation, biological, filtrati... |
41877988 | Record-large indium-oxo clusters: synthesis, hierarchical assembly, and efficient optical limiting. | High-nuclearity indium-oxo clusters (InOCs) represent critical molecular models for understanding indium oxide (In<sub>2</sub>O<sub>3</sub>) nanoparticles, yet their rational synthesis remains a formidable challenge. Herein, we report a dual-ligand strategy to access bixbyite-type In<sub>15</sub>-oxo clusters-the large... |
41869498 | Hybrid Hydrogels in Pain Management Application: A Comprehensive Review. | Hydrogels are widely used in clinical medicine for drug delivery and tissue repair; however, they exhibit limited mechanical strength, suboptimal degradation profiles, and variable biocompatibility. In order to address inherent shortcomings in conventional hydrogels, hybrid hydrogels were engineered by incorporating na... |
41869397 | A Self-Assembling Nanomodulator for Synergistic Therapy of Intracerebral Hemorrhage. | <h4>Introduction</h4>Intracerebral hemorrhage (ICH) has high mortality and morbidity due to a complex secondary injury phase driven by oxidative stress and excessive inflammation. Given the limited efficacy of singularly-targeted therapies, there is a pressing need for novel therapeutic strategies capable of simultaneo... |
41861598 | Regulatory interplay between nitric oxide and heme in redox signaling and inflammation. | Nitric oxide (NO) is a key signaling gas that is involved in a wide range of physiological and pathophysiological processes. NO signaling is closely linked to its interactions with heme, an abundant iron-containing tetrapyrrole in the organism. While heme plays vital roles as a prosthetic group in hemoproteins, it can ... |
41861452 | Smartphone-assisted lateral flow nanosensor for the selective detection of GHB in urine. | We report a rapid test strip based on mesoporous silica nanoparticles functionalized with a specific GABA<sub>B</sub> receptor agonist to selectively detect γ-hydroxybutyric acid (GHB) in urine samples. The sensing mechanism involves rhodamine B-loaded MCM-41 silica nanoparticles whose pores are capped with a GABA-deri... |
41855911 | Synergistic Zn vacancies and Ohmic junction in zinc metal-organic framework derived nanosheet photocatalysts for enhanced CO<sub>2</sub> photoreduction. | Selecting appropriate catalyst to photochemically reduce CO<sub>2</sub> into high-value fuels is an effective way to achieve carbon neutrality. However, single-component semiconductors still suffer from rapid electron-hole recombination. Herein, a promoted charge transfer on a Zn-vacancies-modified ZnS\NiS nanosheets c... |
41850384 | Docking-Assisted Hybridization Chain Reaction Strategy Based on Bifunctional Hairpin Probes for Ultrasensitive Analysis of 17β-Estradiol. | 17β-Estradiol (E2), an endogenous estrogen, can be present in milk and may accumulate during processing, potentially contributing to long-term dietary exposure that raises concerns for consumer health. Regulatory agencies have established intake limits to minimize risk, highlighting the importance of reliable monitorin... |
41849893 | Advances in conductive supramolecular hydrogels for applications in wearable electronics. | Nature is full of fascinating examples where physical strategies help achieve adhesion, self-healing, climbing, and attachment. For instance, reptiles climb walls without falling to the ground, and DNA double helix reannealing, as well as protein folding and refolding, occur due to noncovalent interactions. Similarly, ... |
41847552 | Hydrogel-based delivery systems for cutaneous melanoma therapy: from chemical design and crosslinking strategies to structure-activity relationships. | Cutaneous melanoma, a malignant neoplasm originating from melanocytes, has exhibited a steadily rising incidence worldwide. Conventional therapeutic strategies often suffer from limited precision, resulting in significant off-target toxicity or failure to prevent disease recurrence. Hydrogels have emerged as a promisin... |
41847546 | Engineering novel NiCoZn oxide@carbon porous framework/NiCo<sub>2</sub>S<sub>4</sub> composites derived from MOFs for high-performance hybrid supercapacitors. | The rising demand for sustainable energy has intensified research on supercapacitors that can achieve high energy density, rapid power delivery, and excellent cycling durability. To achieve these attributes, considerable research has been directed to engineering diverse electrode materials, including carbon-based struc... |
41847547 | Sustainable Congo red (CR) and hexavalent chromium [Cr(vi)] removal using graphene functionalized aminated lignin composite: mechanistic and reusability insights. | This research aims at introducing a new composite capable of removing both a textile dye [Congo red (CR)] and a toxic metal, [hexavalent chromium Cr(vi)], from wastewater using a single material. The composite was developed through a facile and eco-friendly approach utilizing microwave-exfoliated graphene (MG) with bio... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.