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41848822 | Nickel Single-Atom Nanozyme for Multimodal Cancer Therapy. | Nickel has recently emerged as a promising catalytic center for single-atom catalysts, owing to its biological relevance, redox versatility, and favorable coordination chemistry. Herein, we report the synthesis of a multifunctional nanozyme (Ni/PEG-FA) comprising atomically dispersed nickel sites anchored on a nitrogen... |
41848808 | Reconfigurable Mechanically Interlocked Metal-Organic Nanocages for Adaptive Guest Recognition and Allosteric Regulation. | Replicating the allosteric regulation of biological systems in synthetic nanostructures remains a fundamental challenge in supramolecular chemistry. Here, we report a reconfigurable Pd<sub>2</sub>L<sub>4</sub> nanocage (<b>Ex-MC</b>) that undergoes thermally triggered mechanical interlocking to form a Pd<sub>4</sub>L<s... |
41848751 | Hard meets soft: tuning binary ferrofluids. | We study binary ferrofluids composed of multicore "nanoflowers" of magnetically hard CoFe<sub>2</sub>O<sub>4</sub> and magnetically soft MnFe<sub>2</sub>O<sub>4</sub>, as a way to optimise heat dissipation while suppressing aggregation-properties essential for biomedical applications. Bulk magnetometry and molecular dy... |
41848647 | o-Terphenyl-Based Family of Conjugated Macrocycles: Selective Recognition of Phenylalanine in Water and Interaction With Insulin. | The design of supramolecular receptors for amino acids presents a fundamentally challenging yet highly promising avenue of research. Phenylalanine attracts special attention because of its multifaceted role in living organisms. Although many synthetic hosts have been explored for recognition of phenylalanine (Phe), bes... |
41848645 | Smart Macrocycles: Cyclodextrin-Porphyrin Photosensitizers for Photodynamic Therapy in Human Bladder Cancer Cells. | Urothelial carcinoma of the bladder is one of the most common malignancies of the urinary tract. It remains a therapeutic challenge due to its high recurrence rate and resistance to conventional treatments. Photodynamic therapy (PDT) is an attractive, minimally invasive alternative that enables spatially controlled tum... |
41848619 | A Chirality-Guided Molecular Recognition Strategy for Targeting Intrinsically Disordered Proteins. | Some peptide sequences are known to interact with their enantiomers to form stereocomplexes. However, the sequence-dependent conditions required for stereocomplexation have not been thoroughly elucidated. Here, we present a systematic investigation of peptide stereocomplexation using short tripeptides and their enantio... |
41848603 | Curvature-Engineered Steering of Oxygen Electroreduction Pathways on Single-Atom Catalysts. | Single-atom catalysts (SACs) are a promising class of electrochemical oxygen reduction reaction (ORR) catalysts, enabling either a four-electron (4e<sup>-</sup>) pathway for energy conversion or a two-electron (2e<sup>-</sup>) pathway for H<sub>2</sub>O<sub>2</sub> production. However, the precise control and optimizat... |
41848592 | Three-Dimensionally Anchored Multiple Resonance Emitters via Intramolecular Noncovalent Interaction Enhancement for Efficient, Stable, and Narrowband Blue OLEDs. | Developing efficient and stable blue organic light-emitting diodes (OLEDs) remains challenging due to the inherent trade-off between efficiency and operational lifetime. While multiple resonance thermally activated delayed fluorescence emitters offer narrowband emission with reduced excited-state energy, their planar s... |
41848532 | Enantioselective Intermolecular Photocycloaddition of Indoles. | The synthesis of cyclobutane-fused heterocycles via photocycloaddition (PCA) of heteroarenes has been widely explored. However, achieving high enantioselectivity remains challenging. Represented herein is a report on an efficient and enantioselective intermolecular [2+2] cycloaddition of indoles with various alkenes an... |
41848523 | A machine learning-assisted Cu-MOF/OPD/RB triple-emission ratiometric fluorescence sensing platform for the detection and discrimination of glutathione. | Herein, a machine learning-assisted Cu-MOF/OPD/RB triple-emission ratiometric fluorescence sensing platform has been developed for the highly sensitive and selective detection of glutathione (GSH). The bifunctional Cu-MOF serves as the core, exhibiting intrinsic blue fluorescence at 450 nm and peroxidase-like activity ... |
41848513 | Electronickel-Catalyzed Stereoselective Synthesis of Butafulvenes. | The highly selective construction of highly strained frameworks remains a formidable synthetic challenge. We report here an electrochemical nickel-catalyzed strategy that enables the regio-, chemo-, and stereoselective synthesis of butafulvenes, constitutional isomers of benzene featuring a cyclobutene core and two exo... |
41848504 | Homochiral Birefringence Hydrogen-Bonded Organic Framework Films for Highly Circularly Polarized Luminescence. | Development of homochiral hydrogen-bonded organic framework (HOF) film for highly circularly polarized luminescent (CPL) remains a significant challenge. In this study, we aim to construct HOF materials that integrate strong CPL with high chiral ordered structure through rational molecular design and supramolecular sel... |
41848503 | Boracycle-Annulation Stabilizes Antiaromaticity and Enhances Diradical Character in s-Indacene/Dicyclopenta[b,g]Naphthalene-Cored Organoboron Polycyclic Hydrocarbons. | For antiaromatic polycyclic hydrocarbons (PHs), heterocycle-fusion is an efficient approach to alter their electronic structures and physical properties. Herein, we disclose pristine boracycle-annulation of antiaromatic π-systems. Two organoboron PHs designed by fusion of 1-boraphenalenes onto one s-indacene or dicyclo... |
41848483 | Cylindrical Cycloparaphenylene Triple-Decker. | The bottom-up synthesis of discrete molecular cylinders consisting of three axially aligned cycloparaphenylene (CPP) layers remains elusive. Here, we report the first synthesis and characterization of a well-defined CPP triple-decker molecule, denoted as CPP-TD, which maintains a persistent cylindrical geometry at room... |
41848480 | An AlFFIVE-1-Ni-Based Humidity Sensor with Fast Response-Recovery Speed. | Humidity sensors based on porous materials have demonstrated broad application prospects in the field of relative humidity (RH) monitoring due to their unique advantages. In this work, a high-performance resistance-type humidity sensor was successfully fabricated using the MOF-type humidity-sensitive material AlFFIVE-1... |
41848425 | Profiling presynaptic scaffolds using split-GFP reconstitution reveals cell-type-specific spatial configurations in the fly brain. | Characterization of intracellular synapse heterogeneity aids in understanding the intricate computational logic of neuronal circuits. Despite recent advances in connectomics, the spatial patterns of synapses and their inter-individual variability remain largely unknown. Using directed split-GFP reconstitution, we achie... |
41848417 | Mycobacterial metallophosphatase MmpE acts as a nucleomodulin to regulate host gene expression and promote intracellular survival. | <i>Mycobacterium tuberculosis</i>, the causative agent of tuberculosis, remains a major global health challenge. Nucleomodulins, bacterial effectors that target the host cell nuclei, are increasingly recognized as key virulence factors, but their roles in mycobacterial pathogenesis remain incompletely elucidated. Here,... |
41848323 | Engineered antimicrobial-derived peptides to manipulate mixed microbial systems. | Due to the complexity of microbial communities and coarseness of currently available manipulation techniques (e.g., transplantation and antibiotic treatment), it is often difficult to fully elucidate the interactions between members that define community structure and function from the top down. Thus, it is imperative ... |
41848315 | Delactylation of viral proteins by SIRT1 suppresses influenza A virus replication. | Lactylation, a protein post-translational modification driven by lactate, plays crucial roles in various physiological and pathological processes. However, the function and underlying mechanisms of lactylation in infection and pathogenesis of influenza A virus (IAV) remain poorly understood. Here, we demonstrated that ... |
41848204 | Targeting Iron Homeostasis Curtails Mosquito Fertility and <i>Plasmodium</i> Transmission Potential. | Iron metabolism is essential for both mosquito reproductive fitness and <i>Plasmodium</i> development within the mosquito, yet this axis has remained insufficiently explored as a potential target for malaria control. Ferritin, the major iron-storage protein and a central regulator of iron homeostasis, has not been bioc... |
41848083 | Gel-to-Gel Transformation in an Fe(III) Metallohydrogel: Kinetic Modulation, Mechanistic Insights, and Dual-Responsive Intrinsic Nanozyme Activity. | Nanodimensional metallohydrogels with fascinating supramolecular architectures showing potential enzyme-mimicking behavior are a key concern in current research. Here, we have addressed a wet chemistry approach for the synthesis of an Fe(III) metallohydrogel employing the sodium salt of 5-sulfoisophthalic acid. At the ... |
41848017 | Nanoparticle-Based Membranes on Coacervates: From Interfacial Assembly to Biomimetic Applications. | Coacervates formed by liquid-liquid phase separation have become important cell-like models for building protocells and simulating intracellular microenvironments. However, the dynamic instability and functional constraints of their membraneless structures have significantly limited the applications of these systems in... |
41847989 | Discovery of Novel Trisubstituted Pyridine Derivatives as EED-H3K27me3 Inhibitors for the Treatment of Multiple Sclerosis. | Multiple sclerosis (MS) is an autoimmune neurodegenerative disorder of the central nervous system (CNS) with a significant unmet need for new therapeutic options. Targeting embryonic ectoderm development (EED) is a potential novel therapeutic strategy for treating MS. Herein, based on optimization of potency and pharma... |
41847836 | A Fluorescent Palladium-Ligand Platform for In Situ Monitoring and Bayesian Optimization of Sonogashira Coupling Reactions. | Palladium-catalyzed coupling reactions are indispensable tools for carbon-carbon bond formation, yet their optimization and real-time monitoring remain challenging in homogeneous catalytic systems. Herein, we report a multifunctional fluorescent ligand, (<i>E</i>)-<i>N</i>'-((1<i>H</i>-benzo[<i>d</i>][1,2,3]triazol-6-y... |
41846414 | Confinement Catalysis Enables Macrocyclization at Up to 0.6 M: Selective Formation of Mono- and Dimeric Glycosidic Macrocycles. | Macrocyclic compounds are widespread in nature and frequently found among bioactive natural products. Their conformational preorganization allows them to effectively engage large binding surfaces, making them valuable in drug discovery, especially for modulating protein-protein interactions. Consequently, macrocyclizat... |
41777230 | Selective decarboxylative dimerization enabled by a supramolecular template on Ag(111). | On-surface synthesis with high selectivity remains a central challenge in surface-confined organic reactions. This study investigates the decarboxylative coupling reactions of heptaazaphenalene-tribenzoic acid (HTBA) molecules on the Ag(111) surface and demonstrates that a thermally persistent supramolecular ribbon ass... |
41767314 | Viral mechanisms, tropism, and clinical relevance regarding the ophthalmic manifestations of SARS-CoV-2 infection. | To explore the mechanisms underlying ocular infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we conducted a comprehensive review of current literature, focusing on viral entry pathways, receptor expression in ocular tissues, and associated clinical manifestations. This review encompasses studi... |
41755694 | Novel hydrogen bonding of a C(sp<sup>2</sup>) atom in planar tetracoordinate carbon molecules. | In planar tetracoordinate carbon (ptC) molecules, the carbon atom is bonded to four other atoms <i>via</i> sp<sup>2</sup> hybridization and multi-center 2-electron bonding, and thus, the p-orbital has a lone pair of electrons. Hence, the carbon atom in ptC molecules is electron-rich and can act as a hydrogen bond accep... |
41744143 | Supramolecular adenosine-based skin delivery system for hair regulation and restoration. | Adenosine (Ado) is known for its well-established biological activities in regulating inflammation, oxidative stress, and tissue repair. However, its practical application is limited by poor water solubility, low transdermal permeability, and inadequate stability, which collectively hinder its bioavailability and targe... |
41744437 | Electronic properties and electrical mobilities of cationic silver hydride clusters. | Cationic silver hydride clusters (Ag<sub><i>n</i></sub>H<sup>+</sup>) can be formed by a number of physical and chemical processes, holding great promise for a range of applications including photonics, catalysis, sensing, and biomedicine, among others. Here, we present a comprehensive theoretical investigation of Ag<s... |
41670219 | A lung-targeted self-assembled supramolecular nanofiber for synergistic therapy of idiopathic pulmonary fibrosis. | Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease with limited therapeutic options and high mortality rates. As an FDA-approved tyrosine kinase inhibitor, nintedanib (BIBF) effectively inhibits pulmonary fibrosis progression in the short term but offers limited clinical benefit. Drugs with synerg... |
40986461 | Multiscale Bionic Construction of Artificial Bone: Strategies and Clinical Application Prospects. | The development of effective biomaterials for bone defect repair remains challenging due to limitations in mechanical properties, bioactivity, and degradation characteristics. We summarize recent progress in synthetic bone materials, including metals, ceramics, and polymer composites, critically analyzing their clinica... |
42007308 | Supramolecular Assembly of End-Functionalized Polystyrene and Polydimethylsiloxane with Hybrid Nanostructures. | Blends of oppositely charged polymers are capable of self-assembling into well-ordered nanostructures via supramolecular self-assembly. A series of monosulfonated-terminated polystyrene (PS) and monopiperidine-terminated poly-(dimethylsiloxane) (PDMS) polymers with different molecular weights were synthesized and blend... |
42006714 | An overview of recent flexible- and soft-biomaterial applications in myocardial infarction and other cardiovascular diseases. | Cardiovascular diseases are currently the leading cause of mortality globally, with myocardial infarction representing one of the most prevalent and severe condition greater than even cancer. Current medical approaches are generally based on preventing and treating various post-infarction complications, failing to rest... |
41993610 | Translational Models for Glioblastoma: Revolutionizing Drug Development and Personalized Medicine through Clinical Insights. | Glioblastoma (GBM) remains one of the most aggressive and treatment resistant brain tumors and continues to present major challenges for effective therapeutic development. The failure of numerous late-stage clinical trials highlights the limited predictive value of conventional preclinical models. Although established ... |
41993615 | Ganglioside enhances the immunogenicity of nanoparticles displaying short synthetic tumor neoepitopes and epitopes. | <h4>Rationale</h4>Short major histocompatibility class I epitopes can be coupled to the surface of immunogenic liposomes to elicit antigen-specific CD8<sup>+</sup> T cells with vaccination. Here, we examined whether the co-incorporation of GM3 ganglioside, a lipid which targets CD169, a sialic acid-binding receptor, wo... |
41971407 | Photostability and antimicrobial performance of natural yellow pigments in food systems: Insights into light-induced degradation and functional consequences. | Natural yellow pigments such as bisdemethoxycurcumin (BDMC), curcumin (Cur), and geniposide are increasingly investigated as clean-label antimicrobial agents due to their reactive oxygen species (ROS)-mediated activity. However, their performance in food systems is often limited by photodegradation under visible light,... |
41970605 | Transgenerational reproductive risks of BPA: epigenetic mechanisms and biomarker applications. A critical review. | Bisphenol A (BPA), which is a common ingredient of plastics and epoxy resins, is among the most commonly found endocrine-disrupting chemicals in the human environment. Chronic human exposure has raised concerns over its effects on reproductive health. There is growing evidence showing that BPA causes epigenetic changes... |
41960421 | Molecular basis of fox ACE2 recognition by receptor binding domains of SARS-CoV-2 and PCoV-GD. | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive RNA detected in red fox swab samples provide evidence of a natural SARS-CoV-2 infection in this species. Many studies have also demonstrated that the red fox angiotensin converting enzyme 2 (fACE2) could serve as the receptor of SARS-CoV-2 and ma... |
41953718 | Thermoreversible cell-derived extracellular matrix only hydrogel (CEOgel): Development, characterization, and applications. | Decellularized extracellular matrix (dECM) has been widely used as a biomimetic material for three-dimensional cell culture and tissue regeneration. Although tissue-derived ECM is the conventional source of dECM, cell-derived ECM (cECM) has emerged as an attractive alternative. Various cECM-based formulations such as p... |
41953721 | Membrane-camouflaged nanoparticle alleviates intervertebral disc degeneration via oxidative stress suppression and autophagy activation. | Oxidative stress, mitochondrial dysfunction, and autophagy imbalance form a vicious cycle driving intervertebral disc degeneration (IVDD). However, comprehensive therapeutic strategies remain limited. To address this, we engineered a biomimetic nanoparticle (NPCM@CeO<sub>2</sub>-RAPA) by encapsulating cerium oxide (CeO... |
41953483 | Molecular engineering of metalloporphyrins and phthalocyanines for homogeneous and heterogeneous CO<sub>2</sub> electroreduction. | This review provides an overview of recent advances in CO<sub>2</sub> electrocatalysis, starting with the development of homogeneous electrocatalytic systems. We focused on porphyrin and phthalocyanine based molecular catalysts where different chemical strategies have been implemented drawing inspiration from natural e... |
41953426 | {5,15-Bis[3,5-bis-(6'-methyl-2,2'-bipyridyl-6-yl)phen-yl]-10,20-di-phenyl-porphyrin}zinc(II) 1,2-di-meth-oxy-ethane 0.296-solvate. | In the title compound, [Zn(C<sub>88</sub>H<sub>60</sub>N<sub>12</sub>)]·0.296C<sub>4</sub>H<sub>10</sub>O<sub>2</sub>, the porphyrin macrocycle is essentially planar, with the Zn atom located in the plane on an inversion centre. The non-substituted and bi-pyridine-bearing phenyl rings are twisted with respect to the po... |
41953344 | A PtS-like 4<sup>2</sup>.8<sup>4</sup> topology arising from the self-assembly of square-planar nodes <i>via</i> organotin units: synthesis and crystal structure of the metal-organic framework {[(PhCH<sub>2</sub>)<sub>3</sub>Sn]<sub>2</sub>Ni(CN)&l... | The self-assembly of K<sub>2</sub>[Ni(CN)<sub>4</sub>] with (PhCH<sub>2</sub>)<sub>3</sub>SnCl in a 1:2 molar ratio affords the title three-dimensional coordination polymer, poly[hexa-benzyl-tetra-μ-cyanato-nickel(II)ditin(IV)], [NiSn<sub>2</sub>(C<sub>7</sub>H<sub>7</sub>)<sub>6</sub>(CN)<sub>4</sub>] <sub><i>n</i></s... |
41953335 | Crystal structure of (dibenzo-21-crown-7)di-iodido-samarium(II) 1,2-di-meth-oxy-ethane hemisolvate. | The title compound, [SmI<sub>2</sub>(C<sub>22</sub>H<sub>28</sub>O<sub>7</sub>)]·0.5C<sub>4</sub>H<sub>10</sub>O<sub>2</sub> or Sm(dibenzo-21-crown-7)I<sub>2</sub>·0.5dimethoxyethane, was obtained as a minor product by layering di-meth-oxy-ethane solutions of SmI<sub>2</sub> and dibenzo-21-crown-7. The asymmetric unit ... |
41953215 | Interfacial Polymerization of TEPA and HMDI: The Role of Water. | The interfacial polymerization (IP) between tetraethylenepentamine (TEPA) and 4,4'methylenebis (cyclohexyl isocyanate) (HMDI) at the inorganic-organic solvent interface happens so fast that it is difficult to control the reaction and the morphology of the polymer. Through quantum mechanical (QM) calculations and molecu... |
41943321 | Physicochemical properties and molecular weight-dependent gut microbiota modulation of inulin-type fructans from Codonopsis bulleynana. | The therapeutic efficacy of dietary fibers is closely related to structural heterogeneity, yet the impact of chain length on physicochemical behavior and gut microbiota modulation remains unclear. Herein, three homologous linear β-(2 → 1)-linked inulin-type fructans with distinct molecular weights, hereafter referred t... |
41939936 | Mechanistic insight into polysaccharides and ultrasound synergistic enhancement of the quality of low-salt surimi gels. | To address gel network deficiencies in low-salt surimi caused by the poor solubility of myofibrillar proteins, a strategy combining different polysaccharides (carrageenan, chitosan, or curdlan) with ultrasound-assisted heating at 40 °C (US40) was investigated to elucidate their structure-function relationships. A syner... |
41939402 | Dopant-Free and Self-Charged Gel-Type Polyelectrolytes for Supercapacitors. | With the increasing demand for wearable and flexible energy storage devices, there has been significant interest in developing safe and mechanically stable prototypes. For this, liquid electrolytes for batteries and supercapacitors (SC) need to be replaced by self-charged gel-type polyelectrolytes (SCGPE), which exhibi... |
41939374 | Retraction of "Assessing the Performance of Al<sub>12</sub>N<sub>12</sub> and Al<sub>12</sub>P<sub>12</sub> Nanostructured Materials for Alkali Metal Ion (Li, Na, K) Batteries". | [This retracts the article DOI: 10.1021/acsomega.2c04319.]. |
41939371 | Phase Diagram-Enabled Curcumin Isolation and Purification by Utilizing Resorcinol as Cocrystal Former and Additive. | In this study, cocrystallization was explored as a method for purifying a compound from a complex mixture. Using the case of curcumin purification, resorcinol was selected as the additional component due to its propensity to form a cocrystal with curcumin in a mole ratio of 1:1. To enable a proper process design, a ter... |
41939364 | CO<sub>2</sub> Adsorption Capabilities of Functionalized Dyn[4]arenes. | Carbon dioxide (CO<sub>2</sub>), a natural gas present in the Earth's atmosphere, continues to produce a greenhouse effect that locks our planet into a trajectory of warming. In the global effort to combat this concerning effect, various suggestions and ideas are constantly being considered and investigated. This repor... |
41939349 | MFDR-DTI: Multisource Feature Decoupling and Dual-Level Reorganization Fusion for Accurate Drug-Target Interaction Prediction. | Predicting drug-target interactions is crucial for accelerating modern drug discovery. Although deep learning-based approaches have achieved significant progress, effectively integrating biochemical features originating from heterogeneous data sources and multilevel representations remains a major challenge. To address... |
41939331 | Multicomponent Salts of the Antidiabetic Agent Saxagliptin: Hydration-Assisted Assembly and Lipophilic Aggregation with Carboxylic Acids. | We report the formation of five new salts of saxagliptin (<b>SAX</b>, trade name: Onglyza), an active pharmaceutical ingredient (API) approved by the FDA for the treatment of type II diabetes mellitus. Salt formation is achieved by exploiting the ability of <b>SAX</b> to accept a proton from five pharmacologically acce... |
41939329 | Translational Advances in Chitosan Biomaterials: From Molecular Modification to Clinical Medicine. | Chitosan (CS), a cationic polysaccharide derived from natural sources, has emerged as a critical biomaterial due to its biodegradability, biocompatibility, and antimicrobial properties. The reactive amino and hydroxyl functional groups enable chemical modifications and diverse structural fabrications, expanding applica... |
41939335 | Photoresponsive Polycations Bearing an Arylazopyrazolium Dye. | A set of cationic photoresponsive monomers is synthesized from a phenylazopyrazol dye by <i>N</i>-methylation followed by ion exchange and is converted by free radical polymerization to the corresponding arylazopyrazolium-bearing polycations. By an appropriate choice of the anion, ionic liquid behavior can be implement... |
41935013 | Machine learning-assisted Zr-MOF<sub>Fe</sub>@SECHA fluorescence and colorimetric dual-mode intelligent platform for sensitive LPS detection. | <h4>Background</h4>Lipopolysaccharide (LPS) is a crucial diagnosis biomarker for sepsis. Accurate and sensitive determination of LPS in real samples (human serum and vancomycin) assumes paramount importance in effectively preventing sepsis and promoting public health. Regrettably, traditional detection methods often su... |
41924721 | EV-derived small non-coding RNAs from porcine follicular fluid regulate follicle development using Pandora sequence. | <h4>Background</h4>Follicular fluid extracellular vesicles (EVs) have emerged as critical mediators of intercellular communication during oocyte development. This study investigates the role of small non-coding RNAs (SncRNAs) within porcine follicular fluid extracellular vesicles in regulating oocyte maturation, with a... |
41924564 | Synthesis, characterization, and antifungal activity of chitosan-copper nanocomposites against crop pathogens. | Chitosan-copper nanoparticles (CHT-Cu NPs) were synthesized using an ionic gelation approach and evaluated for their physicochemical properties and antifungal activity against major fungal pathogens of chickpea and citrus. For instance, "In recent years, nanotechnology-based formulations have emerged as promising strat... |
41924480 | Genomic characterization and pathogenicity assessment of a novel strain of duck reovirus identified in China. | The global duck industry faces substantial challenges due to the emergence of novel duck reovirus (NDRV) infections, which are pathologically characterized by splenomegaly, hemorrhagic manifestations, and necrotic lesions in affected birds. Surviving ducklings often suffer from severe growth retardation. Here, we inves... |
41924478 | Phenylpropanoid metabolites from grape leaves contribute to strong defense roles against downy mildew based on physiological and transcriptomic analyses. | Downy mildew caused by <i>Plasmopara viticola</i> seriously affects global grape production. In this study, the cultivars of Moldova and Red Globe were inoculated with <i>Plasmopara viticola</i> separately. The results showed that the inoculated sites on Red Globe leaves were densely covered with white cotton-like myce... |
41924272 | A cell line-derived, immune-competent neurospheroid model to study neuroinflammation and human brain disorders. | <h4>Introduction</h4>Three-dimensional (3D) human brain models have become indispensable tools to investigate neuroimmune interactions and inflammatory processes in the human central nervous system <i>in vitro</i>. Nevertheless, existing models, including brain organoids and other iPSC-derived systems, are often constr... |
41924134 | A review of the current evidence for maintenance therapy in gastric cancer. | <h4>Objectives</h4>Gastric cancer (GC) is usually diagnosed at an advanced stage, and although partial or complete remission can be achieved after first- or second-line treatment, minimal residual disease may remain, with the potential risk of repopulation and recurrence. The main goals of maintenance therapy (MT) at t... |
41923938 | Nano-enabled plant genetic engineering for stress resilience: current advances and future directions. | Plant productivity and food security are increasingly threatened by abiotic and biotic stresses intensified by climate change. Plant genetic engineering offers powerful solutions to enhance stress resilience; however, conventional transformation approaches remain constrained by limited host range, low precision, tissue... |
41923917 | Selenium-induced structural reorganization of polysaccharides from blackened jujube pomace enhances immunomodulatory activity. | <h4>Introduction</h4>Natural polysaccharides exhibit promising pharmacological potential in functional foods. However, their structural heterogeneity and limited bioactivity hinder further applications.<h4>Methods</h4>In this study, a polysaccharide from blackened jujube pomace was selenylated via the conventional HNO<... |
41909227 | Metal ion-amplified phototherapy for tumors: Mechanisms, nanomaterial design, and synergistic strategies. | Cancer remains a major threat to the health of human for its high incidences and mortality. Traditional treatment methods, such as surgery, radiotherapy and chemotherapy, are often limited by serious side effects and insufficient curative effect. Phototherapy, including photodynamic therapy (PDT) and photothermal thera... |
41908722 | Using Floquet theory to unravel far-from equilibrium dynamics in reaction-diffusion systems. | The interplay between reaction kinetics and diffusion leads to a wide range of spatiotemporal behaviors in reaction-diffusion (RD) systems. This article presents a theoretical and computational study of a RD system inspired by experimental observations of the Rho-GEF-Myosin signaling network controlling cell contractio... |
41907577 | Crystal structure of 3-hydroxypropionyl-CoA synthetase (ADP-forming) from <i>Nitrosopumilus maritimus</i>. | The 3-hydroxypropionate/4-hydroxybutyrate (3HP/4HB) cycle in thaumarchaeota contributes significantly to global organic carbon fixation as the most energetically efficient aerobic carbon fixation pathway. The thaumarchaeal 3-Hydroxypropionyl-CoA Synthetase (ADP-forming; Nmar_1309) is crucial to this efficiency, utilizi... |
41902063 | Advances in Immunological Methods for the Detection of <i>Escherichia coli</i> O157:H7: A Review. | <i>Escherichia coli</i> O157:H7 (<i>E. coli</i> O157:H7) is a highly virulent foodborne pathogen with an extremely low infectious dose, making its rapid and accurate detection in food and environmental samples critically important. In recent years, significant progress has been made in immunological techniques for the ... |
41901863 | Rheological Behavior, Filament Stability, and Microstructure of an Extrusion-Processable Kefiran-PG Formulation. | Microbial polysaccharides are attracting increasing interest as water-processable polymers for extrusion-based additive manufacturing due to their ability to form physically stabilized networks without covalent cross-linking. In this study, a kefiran-propylene glycol (PG) formulation was developed to investigate whethe... |
41901866 | Porous Organic Polymers with Azo, Azoxy, and Azodioxy Linkages: Design, Synthesis, and CO<sub>2</sub> Adsorption Properties. | Rising atmospheric CO<sub>2</sub> levels have increased the demand for robust, scalable adsorbents for practical CO<sub>2</sub> capture and separation. Porous organic polymers (POPs) are attractive candidates because their pore architecture and binding site properties can be precisely tuned via building blocks and link... |
41901857 | Molecularly Imprinted Polymer-Based Electrochemical BioSensors for <i>Haemophilus influenzae</i> Rapid Detection. | <i>Haemophilus influenzae</i> (<i>H. influenzae</i>) is an important respiratory pathogen that can cause various invasive and non-invasive bacterial infections requiring rapid and sensitive detection. In recent years, electrochemical biosensors have emerged as a practical alternative for pathogen detection due to their... |
41900674 | Advances in the Use of Ionic Liquids as Smart Lubricants and Additives for Tribological Applications. | Ionic liquids have emerged as a promising class of lubricants and lubricant additives due to their unique physicochemical properties, including negligible vapor pressure, high thermal stability, tunable molecular structure, and strong surface affinity. This review summarizes recent advances in the application of ionic ... |
41900109 | <i>Magnolia officinalis</i> Rehder & E.H.Wilson. Bark Extract and Magnolol Alleviate Allergic Rhinitis via Modulating NF-κB/MAPK Signaling. | <i>Magnolia officinalis</i> Rehder & E.H.Wilson. bark is famous as a traditional herbal medicine used in prescriptions for treating gastrointestinal discomfort, respiratory and inflammatory disorders. Magnolol, one of its principal bioactive constituents, exhibits potent anti-inflammatory and immunomodulatory propertie... |
41900105 | Substituent Effects Control the Biological Activity of Mn(II) Imidazo[1,2-a]pyridine Complexes. | Three new Mn(II) complexes with imidazo[1,2-a]pyridine derivatives were synthesized and structurally characterized in a solid state by single crystal X-ray diffraction, FT-IR and Raman spectroscopy, and thermal analyses. The investigated compounds include [Mn(3-Climpy)<sub>2</sub>Cl<sub>2</sub>(MeOH)<sub>2</sub>] (<b>1... |
41899876 | Ultrasound Patches Toward Intelligent Theranostics: From Flexible Materials to Closed-Loop Biomedical Systems. | Ultrasound patches represent a transformative advancement beyond conventional ultrasonography, evolving into intelligent theranostic systems for personalized healthcare. This evolution is propelled by synergistic innovations in flexible piezoelectric materials and integrated designs. The development of piezoelectric po... |
41899574 | Vitamin D and Hemopoietic Stem Cell Transplantation: Clinical Guidance for GVHD Management and Post-Transplant Outcomes. | Vitamin D is a pleiotropic secosteroid with endocrine and intracrine actions that influence key phases of allogeneic hematopoietic stem cell transplantation. Epithelial barriers, antigen-presenting cells and effector lymphocytes express the vitamin D receptor and enzymes required for local activation, allowing circulat... |
41899570 | The Emerging Melanoma Management: Historical Perspective to Future Directions. | Cutaneous melanoma is an aggressive form of cancer that accounts for approximately 80% of skin cancer-associated mortality. Treatment strategies for melanoma have been rapidly evolving over the past two decades. Clinical outcomes for advanced melanoma patients have improved with the use of immune checkpoint inhibitors ... |
41898597 | Identification of Potential Candidates with Antimicrobial Activity Against Antibiotic-Resistant <i>Staphylococcus aureus</i> Strains: A Hierarchical Bioinformatics Approach. | Antibiotic resistance among several bacteria is a warning sign that reinforces the need for research to identify new compounds that are effective against resistant strains. In this sense, bioinformatics stands out as an excellent tool for identifying drug candidates by using computational methodologies to detect compou... |
41893696 | A High-Coverage Epitope-Based Vaccine Design for EIAV Envelope Polyprotein Using an Immunoinformatic Approach. | Equine Infectious Anemia (EIA) is a retroviral disease of equids, for which there is no vaccine particularly adapted to American viral strains. In this work we searched for possible epitope regions for the surface proteins gp90 and gp45, rationally employing the latest available bioinformatics tools that constitute the... |
41893529 | Evaluating Toxicity and Anti-Osteogenic Activity of Artemisinin-Inspired Endoperoxides in Zebrafish Larvae. | Endoperoxide-containing molecules based on the antimalarial drug artemisinin have demonstrated various biological properties, including modulation of calcium homeostasis. This study evaluated the toxicity and osteogenic activity of five newly developed tetraoxanes (YB1, YB9, YB11, YB17 and T2), alongside three of their... |
41892574 | Food-Grade Microgels for Age-Related Macular Degeneration: Design, Fabrication, and Targeted Delivery. | Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss worldwide and is driven by complex pathophysiological processes, including oxidative stress, chronic inflammation, complement dysregulation, and vascular endothelial growth factor (VEGF)-mediated neovascularization. Nutritional interv... |
41892572 | Alginate-Based Biomaterials: From Fundamental "Egg-Box" Chemistry to Diverse Biomedical and Metabolic Management of Obesity and Diabetes. | Alginate, a naturally occurring polysaccharide derived from brown algae, has emerged as a versatile cornerstone in the field of biomedical materials. Its widespread adoption is driven by its exceptional biocompatibility and the unique cation-dependent gelation defined by the "egg-box" model. This review examines the fu... |
41892327 | Architects of the Developing Brain: Cytoskeleton-Organizing Molecules in Neurodevelopmental Disorders. | Different components of the cytoskeleton are very important determinants of brain development. They orchestrate multiple cellular processes involved in all phases of cerebral cortex development. In this review, we summarize current knowledge on the components of the cytoskeleton-microtubules, actin filaments, and inter... |
41884516 | Smart microenvironment-adaptive nanocatalytic hydrogel for sequential antibacterial, anti-inflammatory, and regenerative therapy of biofilm-infected wounds. | Biofilm-infected wounds remain a major clinical challenge, as biofilm infections and persistent inflammation hinder conventional therapies from dynamically adapting to the evolving wound microenvironment. Herein, a smart hydrogel dressing (HCOC) is successfully developed for programmed and pH-responsive therapy by inte... |
41884349 | 3D-printing flexible PLGA scaffold modified with bioorthogonal IGF-1 for skin regeneration. | <h4>Introduction</h4>3D-printing implants have attracted increasing attention for enhancing the regeneration of various wound types. The rigidity of traditional 3D printing materials limits their applicability in skin wound repair. In addition, improving the bioactivity of polymeric materials remains an urgent challeng... |
41884229 | Advances in vehicles for in situ delivery: From classical vectors to biologically inspired structures. | The emerging fields of synthetic biology and gene therapy rely on delivery systems to introduce the nucleic acids and proteins into recipient cells. Hence, the development of delivery tools with high specificity, strong manufacturability, and low immunogenicity can advance these fields. In this review, we summarize rec... |
41869435 | NUP85 as a Pan-Cancer Immune Biomarker: Integrated Multi Omics and Functional Analyses Reveal Its Role in Tumor Prognosis. | <h4>Purpose</h4>NUP85 encodes protein components of the Nup107-160 subunit of the nuclear pore complex, belonging to the Nucleoporins (NUPs) family, potentially implicating its role in human cancer. This study aims to elucidate the potential involvement of NUP85 in cancer pathogenesis.<h4>Methods</h4>Leveraging data fr... |
41869399 | Amphiphilic Chitosan-PEI Hybrid Nanocarrier Enhances Delivery Efficiency and Immunogenicity of PEDV mRNA Vaccines. | <h4>Background</h4>mRNA vaccines require efficient and safe delivery systems to achieve robust antigen expression and immune activation. Chitosan is widely recognized for its biocompatibility and adjuvant properties; however, its application in mRNA delivery remains underexplored. This study aimed to develop a chitosan... |
41869404 | Nanomedicine Targeting Cancer-Associated Fibroblasts in Prostate Cancer: From Biological Mechanisms to Integrated Theranostic Strategies. | Prostate cancer (PCa) is the second most common malignancy in men worldwide. Advanced stages are characterized by tumor heterogeneity, metastasis, and resistance to androgen deprivation therapy and chemotherapy. Cancer-associated fibroblasts (CAFs), the predominant stromal cells in the PCa tumor microenvironment (TME),... |
41869405 | Nanomedicine-Driven Modulation of Signaling Pathways in Hepatic Fibrosis. | The progression of hepatic fibrosis, a critical prelude to cirrhosis and hepatocellular carcinoma, is driven by multiple signaling pathways that activate hepatic stellate cells (HSCs) and cause excessive extracellular matrix (ECM) deposition. This review systematically examines the roles of key pathways, TGF-β1, PDGF, ... |
41868416 | The Therapeutic Role of Biologics in Chronic Rhinosinusitis with Nasal Polyps (CRSwNP): A Review of the Current Evidence. | Chronic rhinosinusitis with nasal polyps (CRSwNP) is a complex inflammatory condition that is primarily categorized as either Type 2 (T2) or non-T2. The T2 inflammatory pathway plays a pivotal role in the pathogenesis of T2 CRSwNP. A significant proportion of patients do not respond to systemic glucocorticoid regimens ... |
41868175 | Pregnanolone-Based Prodrugs as a Strategy for Neuroprotective Drug-Like Compounds: Pregnanolone Pyroglutamate and Its Age‑dependent Anticonvulsant Effects in the 6-hz Seizure Model in Immature Rats. | <h4>Purpose</h4>Pediatric epilepsy remains a major therapeutic challenge due to the high prevalence of pharmacoresistant seizures, and the lack of drugs tailored to immature brain physiology. This study tested a pregnanolone‑based prodrug strategy in which the metabolically labile C‑3 hydroxyl group is transiently mask... |
41864150 | A Calixsalan-based ionizable lipid for macrophage-targeted Trem2 siRNA delivery attenuates atherosclerosis. | Targeting plaque macrophages with siRNA is a promising therapeutic strategy for atherosclerosis, but effective in vivo delivery remains a major challenge. Here, we introduce a therapeutic platform based on a novel ionizable lipid derived from a Calixsalan macrocycle. This lipid enables the formulation of macrophage-tar... |
41864105 | Matrix-dependent degradation kinetics and impurity fingerprinting of cannabidiol (CBD) in polymeric and lipid preservation systems. | Cannabidiol (CBD), a non-psychoactive terpenophenolic compound derived from Cannabis sativa, exhibits broad-spectrum pharmacological activities but is highly susceptible to oxidative, photolytic, and thermal degradation, making it challenging to preserve and use in therapeutics. Therefore, this study compares the prese... |
41856262 | Phagocyte-inspired supramolecular self-assembly design of abiotic cell-mimics for pathogen recognition and eradication. | Pathogens are rapidly evolving resistance against both antibiotics and the human immune system. Artificial cells provide an attractive strategy to engineer cell-like systems from simple abiotic materials, offering tunable properties and facile synthesis compared to complex biological components. Inspired by natural pha... |
41855910 | Bimetallic CuCo-based metal-organic framework/graphene oxide composite-modified electrode as an efficient miRNA-208a detection biosensing platform. | MicroRNA-208a (miR-208a), a cardiac-specific miRNA encoded within the Myh6 gene intron, is critically involved in cardiac pathologies such as myocardial remodeling and arrhythmia. Its recent identification in the bloodstream has generated significant clinical interest as a non-invasive biomarker for the early diagnosis... |
41855837 | Construction of dual-mode sensing platforms based on MPC-B(OH)<sub>2</sub> nanozyme: Colorimetric/electrochemical detection and portable smartphone sensing for foodborne contaminant detection. | Early and portable detection of foodborne pathogens is a key challenge for food safety, as conventional methods suffer from insufficient sensitivity and cumbersome operation. Herein, inspired by cellular compartmentalization, we designed the composite nanozyme MIL-88(Fe)@Pt@COF-B(OH)<sub>2</sub> (MPC-B(OH)<sub>2</sub>)... |
41853578 | Screening pertactin-specific antibodies and evaluating competitive epitope recognition by native mass spectrometry. | Structural characterization of antigen-antibody interactions is critical for understanding protective vaccine responses and development of therapeutic monoclonal antibodies (mAb). Traditional biophysical and biochemical techniques often require the immobilization of one binding partner or provide ensemble-averaged meas... |
41853206 | Exploring the diverse binding ability of SARS-CoV-2 variant RBDs to different antibody classes: a computational study. | The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein is highly immunogenic and structurally dynamic, resulting from continuous evolution and mutations that reshape its antigenic landscape. This study aims to investigate the binding profile between the RBD and four neutralizing antibodies, including class 1... |
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