id stringlengths 4 8 | title stringlengths 1 642 | abstract stringlengths 50 17.9k |
|---|---|---|
41847543 | Design, synthesis and antiproliferative, apoptotic, and immunomodulatory properties of new heteroaryl pyridine-linked 1,2,4-oxadiazoles as prospective dual EGFR/BRAF<sup>V600E</sup> inhibitors. | A novel series of heteroaryl pyridine-linked 1,2,4-oxadiazole compounds (5, 9, 14, 20a-c, 21a-c, and 22a-c) was developed, synthesized, and investigated as prospective inhibitors of EGFR and BRAF<sup>V600E</sup>. The new compounds were investigated for antiproliferative activity against four human cancer cell lines and... |
41847538 | Harnessing synergistic effects in porous carbon/Co-ZnO heterojunction for enhanced visible-light photocatalytic removal of bisphenol A. | Endocrine-disrupting contaminants, particularly bisphenol A (BPA), are prevalent in aquatic environments, posing severe ecological and health risks that demand efficient remediation strategies. Photocatalysis has emerged as a promising enhanced oxidation technology for the mitigation of such recalcitrant organic pollut... |
41847529 | A facile and green approach for the surface coating of phosphorus-silicon functionalized graphene oxide to improve flame retardancy of polyurethane foam. | Polyurethane foam (PUF) is the most widely used polymeric foam due to its excellent thermal insulation properties, low cost, and low density. However, its applications are limited by fire performance concerns and associated safety issues. This study describes the synthesis of a novel flame retardant and an environmenta... |
41847248 | Site-selective bromination of anthracene-maleimide Diels-Alder crystals for tunable afterglow and white light emission. | Efficient and color-tunable organic persistent room-temperature phosphorescence (p-RTP) is highly attractive for applications in colorful displays, advanced information encryption, and sensing. However, achieving such p-RTP remains challenging due to the lack of effective design strategies. Here, we introduce a synergi... |
41847212 | Synergistic Carbon Encapsulation and Silver Decoration Enable Durable and Selective CO<sub>2</sub>-to-Ethylene Conversion on Copper Oxide Photoelectrode. | Chemical alterations in metal oxides during manipulation greatly diminish their potential in artificial photosynthesis. Clarifying and overcoming these changes is crucial for realizing the sustainable generation of solar fuels and chemicals. Here, employing multimodal operando techniques, we elucidated the degradation ... |
41840865 | Formation and Characterization of Noncovalent Walnut Protein Hydrolysate-Polyphenol Complexes: Role of Polyphenol Diversity in Functional Modulation. | The valorization of walnut processing byproducts is crucial for developing sustainable functional ingredients. This study examined noncovalent complexes between walnut protein hydrolysate (WPH) and walnut polyphenols (EA, GA, FA, CA, EC). Binding induced concentration-dependent fluorescence quenching and structural cha... |
41840855 | A Freestanding Ce-MOF Separator with Synergistic Functions for Stable and Safe Room-Temperature Sodium-Sulfur Batteries. | Room-temperature sodium-sulfur (RT Na-S) batteries offer great promise for grid-scale energy storage but face various challenges, such as polysulfide shuttling and sodium dendrite growth. This study develops a freestanding cerium-based metal-organic framework (Ce-MOF) separator (denoted as CM) to address these issues s... |
41840818 | Engineering the ADDomer Nanoparticle Vaccine Scaffold for Improved Assembly and Enhanced Stability. | Virus-like particles (VLPs) are promising platforms for next-generation vaccines due to their ability to present antigens in highly ordered, repetitive geometries emulating pathogen-associated patterns to elicit potent immune responses. The ADDomer is a synthetic dodecahedral VLP scaffold derived from the penton base p... |
41840735 | Diagnostic potential of a multi-antigen ELISA for feline leishmaniosis. | <h4>Background</h4>Leishmania infantum is a sand fly-transmitted zoonotic protozoan, endemic in the Mediterranean basin and responsible for human, canine (CanL), and feline (FeL) leishmaniosis. While dogs are the primary reservoir host, a growing number of FeL cases have been reported in this region despite the absence... |
41840347 | Mapping Epidermal Growth Factor Receptor-1 Sorting Domains in Endosomes with a Calibrated Three-Dimensional Expansion Microscopy Toolkit. | Endosomes are nanoscale intracellular compartments that sort and recycle cell-surface receptors such as epidermal growth factor receptor-1 (EGFR1). Nanometer-scale interactions and coclustering of signaling proteins, cargo, and the membrane are critical to this process, yet direct 3D visualization has been hindered by ... |
41840230 | Enhancing the targeting ability of metal-organic frameworks in cancer therapy and diagnosis. | In cancer diagnosis and treatment, 'accurate diagnosis' and 'targeted therapy' are the primary focus and key goals of many research groups. Metal-organic frameworks (MOFs) have attracted considerable attention in cancer diagnosis and treatment owing to their structural diversity and multifunctionality. Starting in 2010... |
41840116 | Multiplex detection of biogenic amines with SERS sensor array boosted by (metallo)porphyrin-based hydrogen-bonded organic frameworks. | Biogenic amines (BAs), primarily formed through the microbial degradation of proteins, are important markers indicating food fermentation and spoilage. On the demand of on-site monitoring of food quality and safety, electrochemical and optical sensors have been developed, focusing on the detection of the total volatile... |
41839925 | Synthesis, characterisation, computational study, amelioration of ruthenium kesar nanoparticle, antioxidant and glycolytic enzyme activity alterations in cirrhotic liver extract. | Liver cirrhosis represents a progressive vascular and metabolic disease, which results due to chronic inflammatory injury to the tissues and presents with aberrant tissue regeneration, fibrosis with nodular configurations, vascular remodeling, and enhanced portal pressures along with compromised liver functions. In clo... |
41839877 | A novel multi-epitope vaccine induces protective and therapeutic immunity against Helicobacter pylori. | The development of an effective vaccine against Helicobacter pylori remains a major global health priority, aimed at reducing infection prevalence and preventing diseases such as chronic gastritis, peptic ulcers, and gastric cancer. Despite extensive research, no vaccine has yet demonstrated durable efficacy in clinica... |
41839852 | Organic small-molecule NIR-II fluorophores for tumor phototheranostics. | Near-infrared II (NIR-II) fluorophores possess transformative potential for biomedical applications, owing to their deep-tissue penetration, reduced tissue autofluorescence, and low phototoxicity. Recent breakthroughs in molecular engineering have accelerated the development of NIR-II organic small-molecule fluorophore... |
41839827 | Nanoparticles-based phototherapy systems: molecular mechanisms and clinical applications. | Nanoparticle-based phototherapy represents a paradigm shift in precision medicine, harnessing light-activated mechanisms to modulate cellular pathways across a spectrum of diseases. By integrating nanoparticles, phototherapeutic modalities achieve enhanced light absorption and improved targeting and amplification effec... |
41839838 | Conductive coordination nanozyme prodrugs precisely trigger pyroptosis, cuproptosis and ferroptosis for in situ cancer vaccination. | Pyroptosis, which rapidly releases cellular contents through pyroptotic pores, is an ideal method for inducing in situ cancer vaccines, evoking systemic antitumor immunity, and suppressing primary and metastatic tumors. However, the clinical translation of pyroptosis-based therapy is hindered by the inability to spatia... |
41839722 | Spatially Organized DNA-Templated Silver Nanoclusters as Potent Antimicrobial Agents for ESKAPE Infections. | Antibiotic-resistant bacteria cause more than one million deaths annually worldwide. The rapid evolution and horizontal gene transfer among pathogens frequently render newly developed antibiotics ineffective shortly after their introduction, underscoring the urgent need for alternative therapeutic strategies. Nanoscale... |
41838952 | Small Activating RNAs: Delivery and Therapeutic Applications in Disease Treatment. | Over time, RNA oligonucleotides have emerged as critical tools in the field of drug discovery, offering potential therapeutic strategies for various diseases that are considered undruggable by conventional methods. Small activating RNAs (saRNAs) are a distinct subset of artificially designed short RNA duplexes (dsRNAs)... |
41838941 | Rapid Synthesis of MIV-Based Multimetal-Organic Frameworks for Photopolymerization of Methyl Methacrylate under Visible Light. | Metal-organic frameworks (MOFs) are porous materials that have attracted increasing interest for photocatalytic applications. Conventional solvothermal synthesis of photoactive MOFs typically requires high-pressure reactors and time-consuming preparative protocols. This study reports the preparation of Ti-, Zr-, and/or... |
41838909 | High-affinity, structure-validated and selective macrocyclic peptide tools for chemical biology studies of Huntingtin. | Huntington's disease (HD) is a fatal neurodegenerative disorder caused by a Cytosine-Adenosine-Guanine (CAG) repeat expansion in the <i>Huntingtin</i> (<i>HTT</i>) gene, with no disease-modifying therapies currently available. The precise molecular function of the HTT protein is unclear, and the lack of selective chemi... |
41838892 | Codelivery of Doxorubicin and Carvacrol via a β-Cyclodextrin-Hyaluronic Acid Nanogel System for Targeted and Stimuli-Responsive Anticancer Therapy. | Nanogel systems offer transformative potential in overcoming critical challenges of traditional therapies, such as poor solubility, low bioavailability, and systemic toxicity. In this study, nanogels were developed using thiolated hyaluronic acid (HASH) and vinyl sulfonated β-cyclodextrin (CDVS) via a water-in-oil emul... |
41838774 | Graph Neural Networks Model Based on Atomic Hybridization for Predicting Drug Targets. | Accurate prediction of half-maximal inhibitory concentration (IC<sub>50</sub>) values is critical for accelerating drug discovery, yet traditional quantitative structure-activity relationship (QSAR) models often have limited ability to capture both local structural patterns and global physicochemical properties essenti... |
41838686 | Decisions about risk taking: Elaborate dynamics between guests and hosts of peer-to-peer accommodation during COVID-19. | This study explores the influence of COVID-19 on peer-to-peer accommodation, from perspectives of both market performance and guests' mindset. Combination of qualitative and quantitative data, as well as analysis by smaller time unit, enables more subtle insights into participants' behavior. Based on Event System Theor... |
41838682 | Bafilomycin A1 is a promising therapeutic agent against T. spiralis infection by inhibiting the heme-transporting ATP6V0C/HRG-1 complex. | Trichinella spiralis (T. spiralis), a zoonotic nematode that causes severe myositis and systemic morbidity, sustains chronic muscle parasitism through evolutionary adaptations; however, this globally prevalent disease lacks targeted therapies to disrupt chronic infection. Although the heme transport protein HRG-1 has b... |
41838607 | Ions as Substituents: A Supramolecular Hammett Approach for Electrostatic Control of Acidity. | Controlling chemical reactivity by engineering the immediate electrostatic and solvation microenvironment of a reactant is a central goal of chemistry. Crown ethers covalently attached to reactive centers have emerged as a versatile supramolecular motif for modulating reactivity by selectively positioning metal ions ne... |
41838426 | Targeting TNBC: core-shell polycationic polyurea dendrimers with inherent anticancer activity. | Breast carcinoma (BC) is the most common malignancy in women, with triple-negative breast cancer (TNBC) making up 10-20% of cases. TNBC has limited targeted therapies and poor survival due to late diagnosis and metastasis. Dendrimers are precise nanostructures with a three-dimensional globular architecture designed to ... |
41838332 | Tuning magneto dielectric synergy of CoNi composites via confined pyrolysis for microwave absorption. | To address the critical challenges of magnetic particle agglomeration and impedance mismatch in metal-organic framework (MOF)-derived microwave absorbers, this study proposes a synergistic strategy integrating bimetallic doping, hollow structural engineering, and confined pyrolysis. A topological transformation from so... |
41838244 | ¹⁹F MRI radiomic features: in vitro and in vivo repeatability. | <h4>Objective</h4>Using radiomics to compute quantitative imaging features may reveal information beyond standard magnetic resonance imaging (MRI) metrics. We aim to investigate the test-retest repeatability of ¹⁹F MRI radiomic features in phantoms containing two perfluorocarbons and to validate these findings in a pil... |
41838042 | Hydrophilicity-Enhanced NH<sub>2</sub>-MIL-88B(Fe) Integrated Photocatalytic Membrane Reactor for Simultaneous Rejection and Degradation of Low-Density Polyethylene in Water Matrices. | Microplastic (MP) plastic particles with diameters of up to 5 mm have emerged as pervasive global pollutants, posing serious risks to both human and environmental health. In this study, a photocatalytic membrane reactor (PMR) was designed to perform dual functions of filtration and photocatalytic decomposition of low-d... |
41838039 | An Exceptionally Stable Porous Indium-Organic Framework with Enhanced Third-Order Nonlinear Optical Performance. | Molecules featuring extended π-conjugated architectures, strong absorption characteristics, and high degrees of electronic delocalization constitute an important class of third-order nonlinear optical (NLO) materials with distinctive functional properties. In this work, we investigate an indium-based metal-organic fram... |
41838027 | Cyclic Photothermal-Actuated Organic Crystals for Reconfigurable Optical Waveguides. | Photomechanically responsive crystals are emerging as intelligent materials for micro/nano manipulation, biomimetic machines, and adaptive systems. However, their practical deployment is often hindered by limited reversibility and fatigue resistance. Herein, we report an acylhydrazone-based organic compound that forms ... |
41838021 | Trace Capture Hexafluoropropylene From Octafluoropropane via Complete Molecular Sieving Mechanism in a Highly Robust Metal-Organic Framework. | Deep removal of trace hexafluoropropylene (C<sub>3</sub>F<sub>6</sub>) impurity from octafluoropropane (C<sub>3</sub>F<sub>8</sub>) using porous adsorbents is highly promising, but the field still suffers from the lack of benchmark adsorbents capable of overcoming the inherent trade-off between adsorption capacity and ... |
41837869 | Novel 2-(2'-Benzothiazolyl)-benzimidazole-Based Iridium(III) Photocatalysts Exhibit Antiproliferative Effects in 2D and 3D Cancer Cells to Bypass Hypoxia-Induced Resistance. | This study explores the therapeutic potential of seven bis-cyclometalated Ir(III) complexes (<b>1-7</b>), derived from the 2,2'-(benzothiazolyl)benzimidazole scaffold, as highly promising next-generation photoactivatable agents for type I and type II-guided photodynamic therapy (PDT) in lung and colorectal cancers. The... |
41837872 | Injectable and Self-Healing Multifunctional Nanocomposite Hydrogel with an All-in-One Strategy for Efficient Synergistic Photothermal-Sonodynamic-Chemodynamic-Chemotherapy of Pancreatic Cancer. | Traditional pancreatic cancer treatment has long been severely hindered by the dense stromal matrix barrier, which drastically impedes the deep penetration of chemotherapy drugs and thus compromises therapeutic efficacy, leading to unsatisfactory clinical outcomes. An injectable and rapid self-healing hydrogel based on... |
41837813 | DNA Logic Gate-Integrated Peptide Nucleic Acid-Optical Fiber Sensor for Ultrasensitive Breast Cancer Exosome Profiling. | Tumor-derived exosomes (TDEs) have emerged as promising biomarkers for cancer liquid biopsy. However, their phenotypic heterogeneity and trace-level concentrations pose considerable analytical challenges, hampering the advancement of highly sensitive detection platforms. Here, we present a novel biosensing platform tha... |
41837756 | Wireless Wearable MOF-Based NH<sub>3</sub> Gas Sensor Patch with a Zeolite Overlayer for Suppressing NO<sub>2</sub> Interference. | Recent advances in flexible metal-organic framework (MOF) films have injected momentum into the development of wearable gas sensors. However, current MOF-based wearable sensors suffer from mutual interference and often compromise in power consumption and wearing comfort, limiting their suitability for skin-interfaced a... |
41837767 | Native Chemical Ligation of Peptoid Oligomers. | Bioorganic chemists are inspired by natural biopolymers to design peptidomimetic oligomers that can exhibit sequence-structure-function relationships. Biomimetic polymers can be synthesized to incorporate a specific sequence of nonbiological monomer units using a variety of iterative solution-phase or solid-phase react... |
41837731 | Cinchona-Functionalized Crown-Ether-Pinioned Calix[4]arene for a Scalable Asymmetric Organocatalytic Aza-Michael Addition Reaction. | We report an enantioselective aza-Michael addition reaction that is organocatalyzed by cinchonine-functionalized crown-ether-strapped calix[4]arene, which yields the aza-Michael adduct in a high yield (99%) with exceptional enantioselectivity (99.8%). The catalyst could be recycled up to 25 test cycles without any sign... |
41837697 | Deciphering the multidrug resistance paradigm in <i>Candida auris</i>. | <i>Candida auris</i> has garnered substantial clinical and public health attention for its widespread antifungal resistance. Most isolates are resistant to fluconazole, and many, to other drug classes, with acquired resistance to all clinically available antifungal drugs reported. Antifungal resistance is rising alongs... |
41837643 | Identification of thermostability-enhancing mutations in H9N2 avian influenza virus hemagglutinin. | H9N2 avian influenza viruses (AIVs) remain a significant economic burden on poultry production and a persistent zoonotic threat. Hemagglutinin (HA), a surface glycoprotein mediating viral entry and pathogenesis, critically depends on thermostability for its function. Our previous study indicated that recent H9N2 AIVs h... |
41837620 | Study of retroviral restrictions in a Tadarida bat cell line enlightens specific early blocks and TRIM5 locus multiplication. | Studies on retroviral infections in bat cells have revealed lineage-dependent differences in susceptibility level, implicating the presence of retrovirus-inhibiting mechanisms in bats. However, the limited number of bat species studied has hampered the clarification of the specific underlying mechanisms. While studying... |
41837579 | Self-Adaptive Allantoin@ZIF8 Nanocomposite Hydrogel with Resveratrol Synergy for MRSA-Infected Wound Regeneration. | Infected wounds present a formidable challenge to healing due to their complex pathological microenvironment, whereas conventional dressings are often functionally limited and ill-suited to adapt to dynamic wound changes. In this study, based on allantoin-loaded ZIF8 nanoparticles (Alla@ZIF8) and methacrylated quaterna... |
41837550 | Freeze-and-Release Direct Optimization Method for Variational Calculations of Excited Electronic States. | Variational optimization of orbitals in time-independent density functional calculations of excited electronic states presents a significant challenge, as excited states typically correspond to saddle points on the electronic energy landscape. The optimization can be particularly difficult if the excitation involves si... |
41837360 | Rational design of next-generation vaccine adjuvants: From molecular mechanisms to hybrid delivery platforms. | This review provides a comprehensive analysis of the molecular innovations driving vaccine adjuvant research, moving from empirical formulations to rational designs. After outlining clinical benchmarks, we systematically categorize and evaluate emerging experimental adjuvant classes, including cytokine-based agonists, ... |
41837335 | A Robust, Redox-Active Cerium Metal-Organic Framework for the Aerobic Oxidation of Benzylamines to Benzylimines. | Heterogeneous catalysis has become a cornerstone of modern sustainable chemistry and green technology, with growing global emphasis on cleaner, more efficient processes. Here, a highly crystalline and redox-active cerium-based metal-organic framework (<b>1</b>) was synthesized using the 2,5-bis(allyloxy)terephthalic ac... |
41837322 | Atomistic Model for Water Adsorption in Mg-MOF-74: Quantum Chemical Prediction of Structures and Isotherms. | The design of improved metal-organic frameworks (MOFs) for water harvesting requires the reliable prediction of adsorption isotherms, i.e., Gibbs free energies of adsorption, with no other input than the atomic positions. We employ density functional theory (DFT) and show that, in Mg-MOF-74, well-defined adsorption str... |
41837314 | Comprehensive Evaluation and Optimization of Martini Simulations for Dipeptide Self-Assembly. | Accurate prediction of peptide self-assembly remains challenging due to the strong dependence of coarse-grained molecular dynamics (CGMD) simulations on parameter settings. Here, we establish a systematic computational-experimental framework for evaluating and optimizing Martini-based simulations of dipeptide self-asse... |
41837283 | Splicing the narrative: alternative TARDBP splicing and its relation to neurodegeneration in ALS and FTD. | Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are progressive neurodegenerative diseases characterized by the nuclear clearance and cytoplasmic aggregation of transactive response DNA/RNA-binding protein of 43 kDa (TDP43). Alternative splicing of TARDBP, the gene encoding TDP43, leads to a surpr... |
41834717 | Dissolving Microneedles Loaded with Lipid Nanocarriers for Vaginal Delivery of Clotrimazole: <i>In Vitro</i> and <i>Ex Vivo</i> Evaluation. | Vaginal yeast infections, such as vulvovaginal candidiasis (VVC), affect nearly three out of four women worldwide. Reoccurrence is frequent and requires repeated treatments with oral, antifungal medications at high doses. Prolonged treatments contribute to development of resistant fungal strains and the risk of systemi... |
41834522 | Polyelectrolyte Copolymer Nanoreactors: From Colloidal Assembly to Photoredox Activity in Water. | Performing organic photoredox reactions in water remains challenging because most catalysts cannot simultaneously solubilize substrates, control nanoscale organization, and maintain activity under aqueous conditions. We report a photoredox-active polyelectrolyte based on a polydehydroalanine (PDha) backbone covalently ... |
41834403 | Enzyme-Responsive Cyclic Gapmer Antisense Oligonucleotides via Thymidine <i>C</i>5-<i>C</i>5 Cross-Linking within the Gap Region Using a Galactosylated Branched Self-Immolative Linker. | Enzyme-responsive prodrug-type antisense oligonucleotides (ASOs) are selectively activated only in target cells where specific enzymes are highly expressed, exerting therapeutic effects. Specifically, ASOs that are cyclized through enzyme-responsive linkers can impose topological constraints, inhibiting the formation o... |
41617469 | Modulating the cleavage and polyadenylation site: from research tools to therapeutic opportunities. | Almost all protein-coding and long noncoding genes that are transcribed by RNA polymerase II employ cleavage and polyadenylation (CPA) for 3' end maturation of their nascent RNAs. More than 70% of human mRNA genes display alternative polyadenylation (APA), resulting in expression of isoforms using different CPA sites (... |
41535089 | Progress and challenges in profiling protein-RNA and protein-associated RNA-RNA interactions. | RNA binding proteins (RBPs) play essential roles in post-transcriptional gene regulation by interacting with a wide range of RNA targets. In addition to regulating RNA processing via individual RBP-RNA interactions, there is a growing appreciation of the regulatory impact of protein-associated RNA-RNA interactions that... |
41901844 | Structure-Mechanical Relationships in Alginate-Chitosan Polymer Composites. | Alginate-chitosan composites are widely used bio-based materials due to their biocompatibility, biodegradability, and relatively simple processing methods. By combining the complementary properties of alginate and chitosan, these systems offer adjustable mechanical characteristics suitable for applications such as tiss... |
41901845 | Preparation and Characterization of Antibacterial Polyvinyl Alcohol Films Containing <i>Syzygium aromaticum</i> Essential Oil. | The resistance of pathogenic bacteria to antimicrobial agents is currently one of the most significant health challenges. Polymers and nano-polymer composites with antimicrobial properties are widely used, particularly in hospitals, biocompatible implants, and the medical device industry. <i>Syzygium aromaticum</i> (cl... |
41901427 | Plant-Derived Nanocarriers for Drug Delivery: A Unified Framework Integrating Extracellular Vesicles, Engineered Phytocarriers, Hybrid Platforms, and Bioinspired Systems. | Plant-derived extracellular vesicles (PDEVs), engineered phytosomes, bioinspired polymeric plant-based nanoparticles (PBNPs), hybrid phyto-inorganic nanocomposites, green-synthesized metal nanoparticles, self-assembled nanoarchitectures, and multifunctional composites represent a rapidly advancing class of sustainable,... |
41901329 | From Stigma to Therapy: Pharmacological Insights into Saffron Bioactives for Major Non-Communicable Diseases. | <i>Crocus sativus</i> L. (saffron), a sterile geophyte of the Iridaceae family, has been traditionally used in culinary and medicinal practices and is currently gaining attention as a source of pharmacologically active metabolites. The main bioactive compounds (BACs) of saffron, crocin, crocetin, picrocrocin, and safra... |
41900853 | A Green Self-Assembled Nanoplatform of 10-Hydroxycamptothecin and <i>Cordyceps</i> Polysaccharides for Dual Anti-Tumor Efficacy Through Apoptosis and Immune Modulation. | <b>Background:</b> Melanoma is one of the most dangerous types of skin cancer, with its global incidence having surged in recent years. There exists an urgent clinical need for novel therapeutic strategies that combine high efficacy, low toxicity, and multiple mechanisms of action. <b>Methods:</b> This study applies a ... |
41900632 | Advanced Nanoporous and Mesoporous Materials: Emerging Innovations, Multiscale Design, and Future Perspectives. | Nanoporous and mesoporous materials have become some of the most dynamic and rapidly evolving areas of modern materials science [...]. |
41900082 | Cavitand-Mediated Photodimerization of Chalcones: The Effect of Supramolecular Influences and Temperature on Reaction Selectivity. | The photocycloaddition (PCA) of chalcones represents an important reaction pathway for accessing substituted cyclobutanes, which is a molecular framework with utility in synthetic chemistry, materials science, and medicine. In the past, our group has demonstrated the utility of the large cavity of γ-CD as a container f... |
41898546 | Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Perspectives. | Reactive oxygen species (ROS) are inevitable byproducts of aerobic metabolism that exert a dual role in biological systems. At physiological levels, tightly regulated ROS levels function as essential signaling molecules regulating cellular communication, immune defense, metabolic adaptation, and maintenance of tissue h... |
41897747 | The Wine Ecosystem as a Reservoir for Potential Probiotics: A Comparative In Vitro Evaluation of <i>Lactiplantibacillus plantarum</i> and <i>Oenococcus oeni</i> Isolates. | The wine ecosystem constitutes a highly selective ecological niche characterized by low pH, high ethanol levels, sulfur dioxide, polyphenols, and nutrient limitation. During malolactic fermentation, this environment becomes dominated by specialized lactic acid bacteria (LAB), particularly <i>Lactiplantibacillus plantar... |
41893235 | Rational Design of Hollow Nanostructures: Engineering the Cavity Microenvironment for Advanced Electrocatalysis. | Hollow nanostructures have emerged as a pivotal class of nanomaterials in electrocatalysis, offering intrinsic advantages such as high surface-to-volume ratios, reduced density, and economical utilization of precious metals. However, the prevailing research paradigm has predominantly focused on the external shell chara... |
41893234 | Experimental Investigation into Stability, Heat Transfer, and Flow Characteristics of TiO<sub>2</sub>-SiO<sub>2</sub> Hybrid Nanofluids Under Multiple Influencing Factors. | Extensive research and empirical evidence demonstrate that nanofluids enhance heat transfer efficiency in microchannels, but this improvement is often accompanied by increased pressure drop and particle clogging. This study aims to determine the optimal parameters for preparing stable nanofluids and to discuss the effe... |
41892570 | Oleogel Dressings for Skin Therapy: Physicochemical and Bioactive Properties of Cosmetic Oil-Based Systems Enriched with Essential Oils. | Developing potential skincare formulations capable of simultaneously managing infection and promoting tissue repair remains a critical challenge in dermatological care. This study engineered bioactive oleogels using sunflower wax (SFW), rice bran wax (RBW), and 12-hydroxystearic acid (HSA) to deliver a synergistic esse... |
41892569 | Valorized Shrimp Shell-Derived Aerogel for Trace Enrofloxacin Removal from Aquaculture Wastewater: Adsorption Performance and Mechanisms Exploration. | Enrofloxacin (ENR), as a widely used antimicrobial agent in aquaculture, poses potential risks to ecosystems and human health due to its environmental persistence. Therefore, it is of great significance to explore efficient methods for removing ENR from aquaculture wastewater. In this study, a series of shrimp shell-de... |
41855916 | Supramolecular engineering heteropoly blue/liquid metal adhesive coating for convenient integration into solar thermoelectric generator. | Solar thermoelectric generators (STEGs) have emerged as a compelling solution for transforming otherwise wasted long-wavelength sunlight into useful electricity. However, the development of existing STEGs has been significantly hindered by challenging interfacial issues between photothermal materials and thermoelectric... |
41850146 | Molecularly imprinted polymer functionalized graphene transistor sensors for high sensitivity EpCAM detection: A novel strategy for label-free detection of tumor biomarkers. | Epithelial cell adhesion molecule (EpCAM) is a critical tumor biomarker, but its direct analysis in complex human fluids remains challenging due to matrix effects and low abundance. Herein, we developed a novel biosensing platform based on a solution-gated graphene transistor (SGGT) functionalized with a zirconia-based... |
41834456 | Second-Generation Crystalline Sponges Enabling Consistent Structure Analysis Under Standardized Conditions for Diverse Molecules. | Crystallization is typically highly sensitive to even minor structural differences in target molecules. As a result, obtaining crystals of complex compounds often requires extensive trial-and-error experiments for each target molecule. We recently reported a second-generation crystalline sponge (2G-CS), in which a coor... |
41834441 | Bridged Pyrroloindole-CAYC-Gold Complexes: Harnessing Weak Secondary Intramolecular Au···H-C(sp<sup>3</sup>) Interactions in Gold(I) Catalysis. | Gold(I) catalysis has been established as a tremendously powerful tool in organic synthesis and catalysis. Herein, we introduce a new class of electronically- and sterically-hindered N-heterocyclic carbene ligands, termed as bridged cyclic amino(ylide)carbene (<sup>b</sup>CAYC), containing 9H-pyrrolo[1,2-a]indoles as t... |
41834421 | Fluorine-18-Labeled Nucleotide Analogs Targeting Ecto-5'-Nucleotidase (CD73) for Positron Emission Tomography Imaging of Solid Tumors. | Ecto-5'-nucleotidase (CD73) is a potential new drug target for cancer immunotherapy. Its overexpression is associated with various aggressive cancers, including triple-negative breast cancer (TNBC) and pancreatic cancer, making it a promising target for diagnostic imaging. Besides antibodies, small-molecule CD73 inhibi... |
41834392 | Nanoarchitectonics of Metal-Organic Framework Platforms for Enhanced Enzyme Delivery with Preserved Activity. | The targeted delivery of biomacromolecules remains a critical challenge due to their intrinsic instability, limited permeability across biological barriers, and susceptibility to degradation. Herein, we report postsynthetic enzyme encapsulation in reaction-mechanism-guided metal-organic framework nanocarriers (MOF NCs)... |
41834388 | N-Heterocyclic Carbene-Catalyzed Enantioselective Synthesis of Inherently Chiral Pillar[5]arenes. | Catalytic asymmetric synthesis of inherently chiral pillar[5]arene derivatives is promising in materials science, chemical biology, and host-guest chemistry due to their unique pillar structure. In this work, we developed an N-heterocyclic carbene-catalyzed asymmetric intermolecular esterification to construct homo- or... |
41834367 | Morphological Control and Formation Kinetics of Polymer-Induced Self-Assembly in Binary Mixed Solvents. | Polymerization-induced self-assembly (PISA) is a versatile synthetic method that integrates polymerization and molecular self-assembly in a single step. It essentially relies on the decreasing solubility of polymers as their chain lengths increases during polymerization, a change that drives the spontaneous formation o... |
41834355 | Electroreductive Cleavage of C(sp<sup>3</sup>)-N Bonds in Saturated <i>N</i>-Carbonyl Heterocycles. | Ring-opening C-N bond cleavage reactions provide an effective means to convert widespread, readily accessible chiral <i>N</i>-heterocycles into hard-to-attain stereodefined linear amines. Current strategies either rely on the strain-induced release of small aziridine and azetidine rings or, for larger ring systems, req... |
41834294 | V<sub>2</sub>C MXene Nanozyme Attenuates Sepsis-Induced Gut Injury via Paneth Cell Death and ER Stress Regulation. | Sepsis-associated intestinal injury represents a critical pathological event contributing to multiple organ dysfunction, with its pathogenesis closely linked to excessive oxidative stress and hyperactivated endoplasmic reticulum stress. Current clinical interventions lack the capacity for precise modulation of the inte... |
41834257 | Cascade-Targeted Type I/II Sensitizer Enabled by Enzyme-Instructed Self-Assembly for Amplified Sono-Photodynamic Tumor Therapy. | Sono-photodynamic therapy (SPDT) offers a non-invasive, spatiotemporally precise approach to cancer treatment, but its effectiveness is still limited by poor tumor specificity and penetration. To address this, we developed a cascade-targeted type I/II sensitizer, Ce6-TPP-Phe-Tyr (CTPT), which integrates chlorin e6 (Ce6... |
41834243 | Tumor Microenvironment-Triggered Charge-Reversible Molecularly Imprinted Polymers for Dual Cascade Targeting to Enhance Photothermal Therapy. | Mitochondrion, a key subcellular organelle, acts as the cell's energy supplier and metabolic regulator. Given its vital functions and distinct thermal sensitivity, it's a suitable target for tumor photothermal therapy (PTT). However, current mitochondrial targeting agents are easily cleared during in vivo circulation a... |
41834220 | Hydrogen-Bond Locking of MXene/Chitin Biocompatible Electrodes for Flexible Supercapacitors. | Designing efficient ion transport channels in MXene-based flexible electrodes is crucial yet challenging for high-rate supercapacitors. Herein, a biocompatible hydrogen-bonding crosslinking strategy is presented to construct patterned MXene/chitin microsphere (CM) electrodes. Surface modification of MXene nanosheets wi... |
41834189 | Radical-Stabilizing Supramolecular Metallacage for Near-Infrared Photothermal Therapy. | The advancement of photothermal therapy (PTT) hinges on developing photothermal agents that combine high efficiency with exceptional chemical and thermal stability. Naphthalene diimide (NDI) derivatives are promising candidates due to their ability to generate radical anions that absorb in the near-infrared (NIR) regio... |
41834178 | Particle-Size Distribution and Surface Properties Enable Air-Stable Organic Photovoltaics via Self-Assembled Layers. | We report a particle-size-distribution (PSD) and surface-property-guided strategy to decode and optimize self-assembled layers at the NiO<i><sub>x</sub></i>/active-layer buried interface for air-stable, high-efficiency organic photovoltaics (OPVs). A carbazole-based phosphonic-acid self-assembled material, pPhPADCB [4-... |
41834154 | Metal-Organic Framework-Derived Yolk-Shell Phosphides@Hollow Mesoporous Nanosphere Architecture for Capacitive Deionization. | Capacitive deionization (CDI) emerges as a promising low-energy desalination technology to address global water scarcity. However, its performance hinges on the design of advanced electrode materials. Herein, we proposed a novel strategy to prepare the yolk-shell structured transition metal phosphides/hollow mesoporous... |
41834052 | Determinants of service utilization and satisfaction with sexual and reproductive health services among displaced and migrant populations in Nigeria: a cross-sectional study. | <h4>Background</h4>Understanding the determinants of access to sexual and reproductive health (SRH) services in humanitarian settings, and their links to client satisfaction, is essential for effective programming. The primary objective of this study was to describe the levels of utilization of services providing moder... |
41833970 | Synthetic aptamer mechanoreceptors enable cell-specific force sensing and temporal control via DNA circuits. | Cells interpret mechanical cues from their microenvironment with spatiotemporal precision to guide adaptive behaviors. However, engineering synthetic mechanosensing systems with both cell-specificity and programmability remains challenging, especially when targeting ubiquitous classical mechanoreceptors. Here, we intro... |
41833932 | Dynamically assembled photochromic cages operational in water with visible light. | Producing chemical nanostructures that can mimic the efficient adaptability of complicated biological systems to environment changes is among the main goals of nanotechnology. Progress in this area requires understanding of the adaptation mechanisms towards external stimuli at the molecular level. Due to rapid and prec... |
41833012 | Borophene: Crucial Challenges and the Way Forward. | Borophene, a monolayer of boron atoms, exhibits anisotropy in crystallographic structure and hence anisotropic physical and chemical behavior. It has emerged as a disruptive two-dimensional (2D) quantum material due to its exceptional electronic mobility, Young's moduli with half-auxetic nature of crystals and due to i... |
41833010 | Enhanced Energy Transfer from a Metal-Organic Framework to a Highly Confined Organic Phosphorescent Dye. | Three-Dimensional Metal-Organic Frameworks (MOFs) are crystalline, porous hybrid materials with well-defined pore structures, offering isotropic adsorption of molecules in their pore system. We designed and synthesized an organic, phosphorescent di-tert-butyl-carbazole dibenzophenazine chromophore, 11-DTCz-BP, with an ... |
41832762 | Selective Activation of PMS by a Single-Atom MOF in Confined Space: Hydrogen Bond-Assisted Nonradical Pathway and Continuous Flow Verification. | Conventional peroxymonosulfate (PMS) activation often depends on nonselective radicals, limiting efficiency and selectivity. Precise nonradical pathways based on singlet oxygen (<sup>1</sup>O<sub>2</sub>) or high-valent metal oxo species under mild conditions remain difficult to realize. A single-atom cobalt-organic fr... |
41832306 | FGF family in health and disease. | Fibroblast growth factors (FGFs) form an evolutionarily conserved signaling system that governs embryonic patterning, tissue regeneration, and systemic metabolic homeostasis. Through coordinated interactions with fibroblast growth factor receptors (FGFRs) and context-specific cofactors, FGF signaling enables precise sp... |
41832202 | Sustained hydrogen peroxide production via MXene-functionalized supramolecular docking. | Direct photosynthesis of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) from air and water using metal/covalent-organic frameworks offers a sustainable alternative to the conventional energy-intensive anthraquinone process. However, current systems suffer from short operational lifetimes typically 10-100 h due to misma... |
42004259 | Evaluating dietary cholesterol and taurine interactions: Implications for growth performance, bile acid metabolism, and lipid regulation in Chinese mitten crab (<i>Eriocheir sinensis</i>). | Cholesterol serves as a precursor for bile acids and molting hormones, while taurine is involved in bile acid conjugation and lipid regulation in vertebrates. However, their synergetic roles in crustacean nutrition remain poorly understood. This study investigated the interactions between dietary cholesterol (0%, 0.64%... |
41971996 | hnRNPUL1 has a dead polynucleotide kinase domain that regulates RNA and protein interactions. | hnRNPUL1 is a nuclear RNA-binding protein involved in both pre-mRNA splicing and DNA double-strand break repair. Using AlphaFold, we show that hnRNPUL1 has a central folded region consisting of tightly juxtaposed SPRY and dead polynucleotide kinase (dPNK) domains flanked by intrinsically disordered regions (IDRs). The ... |
41950726 | Determination of fenofibric acid in saliva and exhaled breath condensate samples using metal- organic frameworks based dispersive micro solid phase extraction coupled to HPLC-PDA. | This study introduces the use of an ultrathin nickel-benzene dicarboxylate metal-organic framework (Ni-BDC-MOF) for the extraction of fenofibrate. For the first time, the ultrathin Ni-BDC-MOF, known for its exceptional adsorption capacity and structural functionality was utilized as a sorbent for dispersive micro-solid... |
41942187 | W/O/W emulsion-filled egg white gel co-stabilized by protein and γ-cyclodextrin MOFs with multi-chamber encapsulation potential. | Egg white gel (EWG) is a highly important raw and auxiliary material in food industry. With the increasing demand of consumers for nutrition, developing a modification method for regulating the texture of traditional egg white gel while enhancing its nutritional efficacy has become a challenge. Herein, a hierarchical W... |
41942186 | Tailoring the stability of low-salt myofibrillar protein emulsions via a glycation-enzymatic deamidation strategy: An interfacial molecular assembly perspective. | The inherent self-assembly behavior of myofibrillar proteins (MP) under low-salt conditions restricts their application in emulsion-based food systems. This study investigated a dual modification strategy combining protein-glutaminase (PG)-mediated deamidation and dextran glycation to improve the emulsifying performanc... |
41935012 | Molecular recognition-based affinity chromatography strategy for selective separation of cucurbit[5]uril and cucurbit[7]uril on hybrid monolithic materials. | <h4>Background</h4>As a class of star macrocyclic molecules, cucurbit [n]urils (CB[n]) have gained extensive applications across multiple fields, including perovskite batteries, adsorption separation, room-temperature phosphorescence and biomolecular science and so on. The acquisition of high-purity CB[n] presents a si... |
41901842 | Hydrogels-Advanced Polymer Platforms for Drug Delivery. | Optimizing drug administration remains a central challenge in the development of modern therapies, especially in the context of conditions that require spatiotemporal control of active substance release. In this context, hydrogels have been intensively investigated as polymeric platforms for drug delivery, through thei... |
41901768 | Design and Characterization of an HRC-Derived Peptide Inhibitor of Canine Coronavirus Spike-Mediated Fusion. | Canine coronavirus (CCoV), an alphacoronavirus belonging to the <i>Coronaviridae</i> family, is primarily associated with enteric infections in dogs. The ongoing evolution of coronaviruses through genetic recombination and mutation leads to the emergence of novel strains with increased pathogenicity, thereby raising th... |
41901326 | AI-Driven Design of Miniproteins as Potential Allosteric Modulators. | Allosteric modulation has emerged as a powerful strategy for achieving superior selectivity and safety in drug discovery and protein function regulation. Unlike highly conserved orthosteric sites, allosteric pockets are structurally diverse and less evolutionarily constrained, making them particularly suitable for modu... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.