id stringlengths 4 8 | title stringlengths 1 642 | abstract stringlengths 50 17.9k |
|---|---|---|
41809547 | Efficient near-infrared-excitable quantum dot-based triplet-triplet annihilation upconversion with a record anti-Stokes shift <i>via</i> low coverage of mono-styryl-BODIPY ligands. | Ligands anchored on quantum dot surfaces with matched energy levels can significantly enhance triplet-triplet annihilation photon upconversion. In this study, we report a novel surface ligand (monosubstituted styryl-BODIPY) on near-infrared-absorbing lead sulfide quantum dots (PbS QDs) that achieves a high triplet exci... |
41806611 | Biochemical characterization of Sapovirus 2C helicase and identification of pramipexole as a novel inhibitor in vitro. | Sapovirus (SaV) is a major causative agent of acute gastroenteritis in both humans and animals. The virally encoded 2C helicase, which shares low homology with host helicases, represents a promising target for the development of broad-spectrum antiviral drugs. However, the inherent instability of the 2C helicase has hi... |
41799937 | The NLRP3 Inflammasome: Mechanisms of Activation, Regulation, and Therapeutic Opportunities. | The NLRP3 inflammasome is a pivotal signaling platform of the innate immune system that senses a broad spectrum of microbial, metabolic, and environmental danger signals. Its activation leads to the recruitment of ASC and caspase-1, driving the maturation of pro-inflammatory cytokines interleukin (IL)-1β and IL-18 as w... |
41799920 | Multi-scale triglyceride crystal network analysis using a benchtop ultra-small-angle X-ray scattering instrument. | Benchtop ultra-small-angle X-ray scattering (USAXS) offers a practical route to probing micron-scale structural features in soft-matter systems, provided that instrumental limitations are explicitly defined and respected. In this work, a Rigaku NANOPIX mini USAXS instrument is used to characterize hierarchical fat crys... |
41799914 | Tuning the charge distribution of Co-N-C active sites for enhanced trifunctional electrocatalysis. | Previous studies have often focused on optimizing electrocatalytic performance by altering the type of metal centers or the morphological structure of catalysts to modulate their electronic structures and active sites. However, the precise regulation of metal valence states to enhance catalytic performance-particularly... |
41798865 | Research Review on Inhibitors of Lumpy Skin Disease Virus: From Biological Characteristics, Drug Repurposing, to Computer-Aided Drug Design. | This review summarizes the research progress on inhibitors of lumpy skin disease virus (LSDV), focusing on its biological characteristics and key proteins involved in the viral replication cycle. It compiles various inhibitors (direct-acting poxvirus inhibitors and host-directed poxvirus inhibitors) against poxviruses,... |
41798684 | Mapping Intestinal Paracellular Perm Eability in Mice: Regional and Cellular Variability Under Physiological and Stimulated Conditions. | Intestinal paracellular permeability was analyzed ex vivo by incubation of tissue segments at 0°C with the fluorescent dyes FM1-43FX (FM) or TRITC-dextran 3 kDa lysine-fixable (TD3L) and confocal microscopy in (i) healthy mice and (ii) mice submitted to chronic stress or lipid diets. In the small intestine of healthy m... |
41798293 | Growth Performance and Intestinal Health of Triploid Rainbow Trout (<i>Oncorhynchus mykiss</i>) Through Bile Acid Supplementation in Low Fishmeal Diets: Insights From Metabolomics, Microbiota, and Gene Expression. | This research aimed to explore the impact of bile acid (BA) supplementation in low fishmeal diets on growth performance, serum biochemical indices, tissue morphology, lipid metabolism, gene expression, and gut microbiota in triploid rainbow trout (<i>Oncorhynchus mykiss</i>, initial weight 15.97 ± 1.4 g). The experimen... |
41798076 | Plasma enhanced vapor deposition of dipeptide nanostructures: nanotubes to nanoflowers. | The study of self-assembling peptides for synthesizing nanomaterials is a rapidly growing area in biomedical research. In this study, we report a hybrid deposition technique, plasma enhanced chemical vapor deposition (PECVD), as a reliable method for the synthesis of aromatic tyrosine peptide-based nanostructures with ... |
41794361 | Ultrasound-guided nanocomposite hydrogel injection to enhance nerve repair via temporal delivery of a colony-stimulating factor 1 receptor inhibitor. | Persistent or dysregulated neuroinflammation impairs regeneration following peripheral nerve injuries (PNI). Current strategies for modulating inflammation in PNI lack spatial and temporal precision, thereby limiting their regenerative efficacy. In this study, we developed a nanocomposite hydrogel (DNH/PLGA@BLZ) by com... |
41794351 | Hydroxypropyl-β-cyclodextrin as a multifunctional excipient for enhancing stability and aerosol performance of spray-dried protein formulations. | Protein-based drugs are precise therapeutic options for various refractory lung diseases, significantly improving patient prognosis and quality of life. In this study, a comparative spray-drying approach was employed to prepare inhalable dry-powder formulations of bovine serum albumin (BSA), a surface-active model prot... |
41794129 | Near complete corneal regeneration after lamellar keratoplasty in rabbits enabled by an in situ photo-crosslinkable dendrimer-hyaluronic acid hydrogel. | <h4>Purpose</h4>Corneal fibrosis is a leading cause of blindness that often requires corneal transplantation. However, transplantation is limited by donor shortages especially in low and middle-income countries, surgical complexity, and intensive postoperative management. We have developed an in situ photo-crosslinkabl... |
41792011 | Objective assessment of denture adhesive effects on masticatory function in removable partial denture wearers. | <h4>Statement of problem</h4>Clinical studies of the effects of denture adhesive (DA) on removable partial denture (RPD) wearers are scarce.<h4>Purpose</h4>The purpose of this clinic trial was to assess the effects of DA on the masticatory function of RPD wearers and to explore the effects of DA on masticatory performa... |
41790547 | Protocol for the synthesis and characterization of Ru@PCN@PEI nanoparticles with superoxide dismutase catalytic activity. | Bimetallic organic frameworks (BMOFs) possess versatile structural and functional features that enable applications in catalysis and biomedicine. Here, we present a protocol to synthesize Ru@PCN@PEI nanoparticles by loading Ru nanoparticles onto PCN-222(Mn) and coating the surface with polyethyleneimine (PEI). We descr... |
41787819 | One-Dimensional Polycyclic Aromatic Hydrocarbons Incorporating Multiple Dithiafulvene Units-Novel Multi-Redox and Electrochromic Systems. | The combination of polycyclic aromatic hydrocarbons (PAHs) and dithiafulvene (DTF) units provides large π-conjugated scaffolds with multi-redox behavior. Here, we present the synthesis and properties of PAHs containing seven or nine alternating and fused six- and five-membered rings and three or four DTF units located ... |
41787776 | Enantioselective Synthesis of Axially Chiral Anthracenes via [4+2] Cycloaddition and Cycloreversion of Cyclopentadienones. | The sequential inverse-electron-demand [4+2] cycloaddition and cycloreversion of cyclopentadienones with alkynes or alkenes represent one of the most important approaches for the synthesis of polycyclic aromatic hydrocarbons. However, catalytic asymmetric variants of these transformations have not yet been realized. He... |
41787703 | Intertube Interactions in Multivariant Metal-Organic Nanotubes. | Incorporating disparate functionalized ligands into phase-pure metal-organic frameworks (MOFs) has been shown to produce multivariate MOFs (MV-MOFs) whose properties often exceed those of the corresponding linker-pure MOFs. The ability to easily prepare MV-MOFs is due to covalent bonds linking MOF ligands and secondary... |
41787659 | Processable, High-Performance Circularly Polarized Luminescence Architectures for Information Interaction. | ConspectusChirality imparts spin to light─the intrinsic fingerprint of asymmetric matter. When optical spin interacts with molecular or supramolecular chirality, it generates distinctive chiroptical phenomena, with circularly polarized luminescence (CPL) attracting significant attention due to its optical activity and ... |
41787639 | Light-Addressable Organic Photoelectrochemical Transistor: Toward Multiplex Screening of Inhibitor Drugs. | While light-addressable detection has been increasingly studied, no effort has been devoted to study its potential in newly emerging organic photoelectrochemical transistors (OPECTs). Herein, we propose and devise the first light-addressable OPECT, which is exemplified by a nine-channel device with three "detecting" ch... |
41787532 | Bioinformatic and computational biophysics tools for nanopore engineering: a review from standard approaches to machine learning advancements. | Nanopores are key components in several emerging technologies. Nanopore sensors allow the observation of single molecules from the signature they leave in the ionic current flowing through the pore, while nanoporous membranes provide a potentially customizable platform to achieve unprecedented ion selectivity performan... |
41787092 | Nucleoli-localized KANSL2 as an epigenetic regulator of ribosome biogenesis in glioblastoma cells. | KANSL2 is a subunit of the non-specific lethal (NSL) chromatin-modifying complex associated with glioblastoma (GBM) progression, but the intrinsic role of KANSL2 in GBM cells is poorly understood. By analyzing TCGA-GBM and GTEx datasets, we found that KANSL2 is upregulated in GBM and positively correlates with genes in... |
41787078 | Th17/Treg cell imbalance in allergic rhinitis: mechanisms and therapeutic implications. | Allergic rhinitis (AR) is a chronic, noninfectious inflammation of the nasal mucosa. Recent worldwide epidemiological surveys have indicated an increase in AR incidence. Recurrent allergic symptoms, disease complications and prolonged treatment have brought heavy physical and mental burdens to AR patients. AR pathogene... |
41786990 | In situ formation of nanocrystalline Ni(OH)<sub>2</sub> in alkaline electrolyte explains superior capacitance and cycling stability of Ni<sub>3</sub>S<sub>2</sub>/NF electrodes. | The free-standing Ni<sub>3</sub>S<sub>2</sub> electrode was fabricated via a simple one-step hydrothermal method at 160 °C through the sulfidization of nickel foam (NF). The as-synthesized samples exhibited X-ray diffraction (XRD) patterns and Raman spectra consistent with the formation of Ni<sub>3</sub>S<sub>2</sub> A... |
41786974 | Reversibility and therapeutic feasibility of DNM1L-associated neurodevelopmental disorders. | DNM1L-associated encephalopathy is a neurological disorder with a broad spectrum of symptoms associated with mutations in the DNM1L gene. Treatment primarily aims to alleviate symptoms, which is mostly ineffective as the underlying neuropathology is not well understood. Moreover, the progression and reversibility of th... |
41786775 | Altering the carbohydrate-binding specificity of the legume lectin FRIL through structure-guided engineering. | FRIL is a legume lectin from the hyacinth bean that has broad-spectrum antiviral activity. A distinctive trait of FRIL among similar mannose/glucose-specific legume lectins is that FRIL shows specificity for complex type N-glycans. We postulate that an extended binding site on FRIL facilitates this ligand selectivity. ... |
41786728 | Graphene quantum dot membranes with tailorable pores for efficient gas separation. | Membrane materials and fabrication methods often need to be co-developed to meet the specific permeance and selectivity requirements of different gas separation application, which limits the adaptability of membrane technology. Here we propose a post-regulation strategy-adjusting the pore structures of a standard "prim... |
41786712 | Bioinspired nanofluidic iontronic device with integrated photoreceptor and photosynaptic functions. | Biological vision acquires external information through light-induced transmembrane ion transport, generating electrical impulses. Emulating the dual visual functions of photoreceptors and photosynapses through light-modulated ion transport presents a significant challenge. Herein, we present a bioinspired light-regula... |
41786638 | Self-Assembly and Gelation Behavior of Methacrylated PEO-PPO-PEO Triblock Copolymer Pluronic F127. | Methacrylated Pluronic triblock copolymers are widely used as photo-cross-linkable hydrogels, yet the effect of terminal methacrylation on self-assembly and thermoreversible gelation prior to cross-linking remains poorly understood. Here, we systematically investigate how the degree of methacrylation influences micelli... |
41786506 | Lithophilic yet Inert Interfaces Strategy for Stable Lithium Metal Anodes. | In lithium (Li) metal batteries, lithophilic materials play an essential role in stabilizing Li metal anodes. However, it is very difficult to attenuate the reactivity with Li while maintaining their lithophilicity. Herein, we propose a "lithophilic yet inert interfaces strategy" to stabilize Li metal anodes. That is, ... |
41785430 | Substrate-Directed Dimensional and Phase Control of Peptide Assemblies on Two-Dimensional van der Waals Materials. | Understanding and controlling biomolecular self-assembly on van der Waals (vdW) materials has the potential to advance hybrid bioelectronic devices by enabling precise tuning of the interface and modulation of the resulting electronic properties of the biomolecule-vdW heterostructure. However, how surface properties of... |
41785389 | Selective Toxicity of Nicotinic Insecticides: Responsibility of Varied Amino Acid(s) in the Ligand-Docking Pocket between Insect versus Mammalian Nicotinic Acetylcholine Receptors. | Nicotinic insecticides are utilized throughout the world for crop protection and animal care. The selective toxicity of nicotinic insecticides is principally attributable to the specificity of insect versus mammalian nicotinic acetylcholine receptors (nAChRs). The goal of this investigation is to evaluate the responsib... |
41785330 | A Monoborylated Multiresonance Thermally Activated Delayed Fluorescence Emitter Enabling Efficient and Ultranarrowband Red Electroluminescence. | The pursuit of high-efficiency narrowband red emitters for next-generation displays is compounded by the challenge of simultaneously achieving high synthetic yield, narrow spectral line width, and high exciton utilization. Here, we break this trade-off with a high-yield monoborylated multiple-resonance thermally activa... |
41785320 | Identification of CD164 as an essential entry receptor for divergent adeno-associated viruses. | Recombinant adeno-associated viruses (rAAVs) are widely used for in vivo gene delivery. While KIAA0319L, known as AAV receptor (AAVR), is essential for the transduction of multiserotype AAVs, it is dispensable for AAV4-related (Clade G) AAVs. We conducted a genome-wide CRISPR/Cas9 screen and identified CD164, a type I ... |
41785300 | Conformation-Sensitive Active-Site Residue Tyrosine 260 in <i>Paenibacillus macerans</i> Cyclodextrin Glycosyltransferase Governs C13-Regioselective Glycosylation of Rebaudioside A. | Cyclodextrin glycosyltransferase (CGTase) is widely used in stevioside glycosylation, yet achieving precise regioselectivity remains a persistent challenge. Here, 200 ns molecular dynamics (MD) simulations identified residue Y260 in <i>Paenibacillus macerans</i> CGTase as a conformation-sensitive determinant for rebaud... |
41785290 | Immunoinformatics approach to engineer a multi-epitope vaccine against SdrG in skin commensal Staphylococcus epidermidis. | The human skin serves as a dynamic ecosystem for beneficial commensal bacteria such as Staphylococcus epidermidis, which play a crucial role in maintaining skin barrier integrity and modulating immune responses. Remarkably, recent research has demonstrated that the skin can function as a natural vaccination site, produ... |
41785220 | Purification and pharmacokinetic study of gadoxetate isomers for enhanced rabbit liver MR imaging. | This study aimed to purify and prepare two isomers of Gadoxetate (Gd-A and Gd-B) from Pumexian and evaluate their stability, magnetic resonance (MR) imaging characteristics, and pharmacokinetics in rabbits. Reversed-phase liquid chromatography was employed to separate Gd-A and Gd-B, achieving purities exceeding 99% for... |
41785057 | Supramolecular Polymorphism of an Ir(III) Complex: Kinetic/Thermodynamic Control and Mechano-Responsiveness. | Polymorphism is of central importance in pharmaceuticals, crystal engineering, and materials science, where distinct structural forms can yield markedly different properties and functions. However, despite its significance, achieving fine control and reliable prediction of polymorphs, particularly in supramolecular ass... |
41785043 | DNA Logic-Gated CRISPR/Cas13a and PNTs-Hemin Biomimetic Nanozyme for Ratiometric Detection of BRCA1 and circROBO1. | Although nanozyme-based biosensors show great promise for the early diagnosis of cancer, their application is often limited by poor catalytic activity at neutral pH and susceptibility to matrix interference. This study involved the construction of a biomimetic nanozyme through coordination-driven self-assembly on pepti... |
41784976 | Self-Assembly of A<sub>2</sub>B Miktoarm Star Block Copolymer under Cylindrical and Spherical Confinements. | Block copolymers (BCPs) are exciting materials owing to their ability to self-organize, resulting in ordered mesophases in bulk. A rich variety of interesting novel ordered phases can be obtained by subjecting the polymer to geometrical confinement. In the present study, we investigate the self-assembly behavior of A<s... |
41784831 | Modulation of the Spin State of Atomic Fe-N<sub>4</sub> Sites with Interlayer-Adjacent Ir-N<sub>4</sub> for Superior ORR Activity. | Development of efficient and durable oxygen reduction reaction (ORR) electrocatalysts is of great interest yet remains challenging. Herein, we predicted and screened a bilayer graphite carbon-supported Ir-N<sub>4</sub>/Fe-N<sub>4</sub> catalyst with high ORR activity using density functional theory calculations. Subseq... |
41784802 | Branched-chain polyamines: evolutionary adaptation and biotechnological potential. | Branched-chain polyamines (BCPAs), exemplified by N⁴-bis(aminopropyl)spermidine, are distinctive polycations that occur predominantly in thermophilic bacteria and euryarchaeal archaea. Their dedicated aminopropyltransferase, BpsA (EC 2.5.1.128), extends spermidine into branched architectures via sequential decarboxylat... |
41784731 | Triboelectric Nanogenerators for Thermal Management Application: Current Progress and Future Prospects. | The rapid development of wearable electronics, self-powered systems, and the Internet of Things urgently requires efficient thermal management (TM) technologies and sustainable energy solutions. However, triboelectric nanogenerator (TENG) and their integrated electronic components inevitably generate or accumulate Joul... |
41784401 | Air Pollution Monitoring with Nanoscaled Materials in Chemoresistive Gas Sensors. | Air pollution is a pressing global concern due to its negative effects on human health and our ecosystem. For instance, pollutants, including particulate matter, volatile organic compounds, nitrogen- and sulfur-based gases, and ozone, are known to increase the incidence rates of respiratory, cardiovascular, and various... |
41784372 | Automated Nanocrystalline Sponge Workflow Enabled by 3D Electron Diffraction. | The crystalline sponge (CS) method utilizes a crystalline porous material to arrange target molecules within its periodic pores. This enables the determination of the 3D atomic structures of organic molecules without the need for crystallization. However, its applicability is currently limited by the availability of su... |
41784337 | A Multilamellar Lipid-Polymer Progenitor Can Promote the Assembly of Improbable Functional Polymer Complexes at Life's Origins. | The original conditions from which primitive life emerged on the early Earth were likely to be dilute mixtures of organic compounds in aqueous solutions. A significant challenge for origins of life research is to discover the reactions that allowed such mixtures to become increasingly complex with products such as poly... |
41784177 | Smartphone-Paper Sensor for Glutathione Based on a RhB@Zn-MOF Engineered via Synergistic RET and ACE for Ratiometric Detection. | Glutathione (GSH), a crucial biological thiol, is a key biomarker whose abnormal levels are implicated in various diseases. The sensitive, quantitative, and on-site detection of GSH is thus urgently required in biomedical and food-safety fields. Herein, we present a rationally designed dual-emission metal-organic frame... |
41784116 | Size- and Shape-Selective Catalytic Dithioacetalization With an Endohedrally Functionalized Self-Assembled Cage. | An endohedrally functionalized self-assembled Fe<sub>4</sub>L<sub>6</sub> cage complex can catalyze dithioacetal formation from suitably sized and shaped aldehydes and alkanethiols. The cage-catalyzed process is significantly accelerated, compared to small molecule sulfonic acid catalysis, and is selective for dithioac... |
41783994 | Design and Synthesis of Eosin Y-Sensitized MOF-on-MOF Heterojunction Photocatalysts for Enhancing Water Splitting. | Constructing metal-organic framework (MOF) heterojunctions with effective photocatalytic activity, outstanding stability, and integrated redox centers remains challenging. Herein, a chiral [Cu<sup>I</sup>(IPEA)] 1) and an achiral [Cu<sup>II</sup>(IPEA)]·(H<sub>2</sub>O) 2) (IPEA = (E)-3-[4-(imidazol-1-ylmethyl)phenyl]p... |
41783986 | Anion-Controlled Structural Interconversion of Palladium Cages Enables Separations by Selective Guest Capture and Release. | Self-assembled host-guest systems provide a powerful platform for molecular recognition and binding. Achieving the controlled and selective release of bound guests remains challenging, typically relying on destructive stimuli. Herein, we report that asymmetric ligand L assembles to form an interconverting pair of palla... |
41783927 | Linker Dimensionality Regulation Enabled Isoreticular Extension in Copper-Based Metal-Organic Frameworks for Enhanced CO<sub>2</sub> Adsorption and Hydrocarbon Separation. | Isoreticular extension of metal-organic frameworks (MOFs) has proven to be a powerful strategy for targeting appropriate pore shapes and sizes suitable for specific applications while retaining the underlying net topology. However, this strategy can be limiting due to the tendency of elongated linkers to result in comp... |
41782486 | Multiresponsive and Tunable Circularly Polarized Luminescence in Aggregation-Induced Emission Static Helical Supramolecular Polyisocyanides. | The realization of stimuli-responsive dynamic CPL in static helical polymers remains highly challenging. Herein, a novel, covalent, and green synthetic strategy is developed to construct AIE-featured static helical supramolecular polyisocyanides with multiresponsive and tunable CPL properties, via helix-sense-selective... |
41782139 | Rumen microbiota-associated stress alleviation by creatine pyruvate in newly received cattle: a multi-omics study. | <h4>Background</h4>Stress experienced by newly received cattle is a significant challenge in the beef industry, frequently resulting in weakened immune responses and impaired growth. The rumen microbiota is essential to host health, and its imbalance can exacerbate stress. This study investigates the mechanisms by whic... |
41781469 | Silver nanoparticles obtained using cyclodextrin derivatives and pectin as a key component of titanium dioxide-based composites for water purification. | This study investigated the effect of β-cyclodextrin (β-CD), its derivatives, and pectin on reducing Ag<sup>+</sup> ions for the synthesis of silver nanoparticles (AgNPs) and corresponding composites with TiO<sub>2</sub> (TiO<sub>2</sub>/Ag), which were evaluated as high-performance photocatalysts for degrading methyl ... |
41781386 | Personalized pharmacokinetic-pharmacodynamic guided therapy via an induced pluripotent stem cell-derived multi-organoid platform in NF1-mutant breast cancer. | Effective precision oncology demands integration of pharmacokinetics/pharmacodynamics (PK/PD) profiling with tumor-specific genomic features. Here, we present a personalized treatment model using a patient-derived Networking Organoid Culture System (NOCS) composed of intestinal, liver, and kidney organoids differentiat... |
41781373 | Bioengineered α-Hairpin peptide TKH with GKG linker: a LLPS-mediated biomimetic mineralization system for intrafibrillar remineralization and deep dentin tubule occlusion. | Dentin hypersensitivity (DH) originates from collagen exposure and dentinal tubules (DTs) patency caused by mechanical abrasion or demineralization. For an effective long-term therapeutic desensitizing agent, the ability to achieve deep tubular occlusion, stable remineralization, and satisfactory biocompatibility simul... |
41781380 | Unleashing the potential of bimetallic nanobomb-mediated STING pathway to enhance bispecific T-cell engager against colorectal cancer photo-immunotherapy. | The broader clinical application of Bispecific T-cell engagers (BiTEs) is hindered by their short half-life, on-target off-tumor toxicity, and limited therapeutic effect for solid tumors. Herein, we constructed a bimetallic-enriched triple-kill nanobomb manganese/Co<sup>2+</sup>-dopamine@BiTE/HPT (MnO<sub>2</sub>/Co-DA... |
41729128 | Sensing element design in optical pesticide-detecting arrays. | The escalating global reliance on synthetic pesticides to secure agricultural productivity has intensified concerns over their adverse impacts on human health and ecosystems. With pesticide exposure linked to severe pathologies-including neurotoxicity, endocrine disruption, and carcinogenesis-there is an urgent need fo... |
41725514 | A hepcidin homolog from <i>Lateolabrax japonicus</i> inhibits the infection of Anguillid herpesvirus 1 by interacting with the viral envelope protein ORF51. | Frequent outbreaks of eel "mucus sloughing and hemorrhagic septicemia disease" caused by Anguillid herpesvirus 1 (AngHV) are a major epidemic in both wild and farmed eels. This virus has garnered global attention due to heavy losses on eel farms and the lack of protective vaccines or effective drugs, highlighting the u... |
41709762 | Click chemistry-driven heteromolecular integration into layered zeolite frameworks for photochemical upconversion applications. | Organic-inorganic hybrid layered porous materials enabling triplet-triplet annihilation upconversion (TTA-UC) were developed by integrating anthracene-based emitters and metal-complex sensitizers within zeolitic nanospace. Diphenylanthracene (DPA) units were covalently anchored between MWW-type layers <i>via</i> thiol-... |
41709734 | A Li<sup>+</sup>/Zn<sup>2+</sup> hybrid electrolyte revolutionizes V-MOF cathode performance and zinc anode reversibility. | A multifunctional cationic electrolyte additive-Li<sup>+</sup> was incorporated into the Zn‖V-MOF battery, which could enhance the electrolyte's ionic conductivity and accelerate the Zn<sup>2+</sup> diffusion rate, facilitate reversible de-intercalation into the V-MOF cathode, and suppress zinc dendrite formation. |
41705353 | Co-delivery of loaded 4-butylresorcinol and licochalcone A in a supramolecular system for synergistic permeation and whitening effects. | As people age and are exposed to the sunlight for a long time, the excessive production and accumulation of melanin in the skin can affect their appearance and health. In addition, some whitening active ingredients have limitations in terms of solubility, stability, and skin irritation, which prompted us to research mo... |
41308123 | Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2. | The mechanistic target of rapamycin (mTOR) protein kinase forms two multiprotein complexes, mTORC1 and mTORC2, that function in distinct signaling pathways. mTORC1 is regulated by nutrients, and mTORC2 is a central node in phosphoinositide-3 kinase (PI3K) and small guanosine triphosphate Ras signaling networks commonly... |
41993637 | Dual-ligand curcin-loaded hybrid solid lipid nanoparticles achieve durable gliosarcoma remission while preserving neuro-behavioral function. | <h4>Rationale</h4>Gliosarcoma (GSM) is a rare, highly invasive glioblastoma subtype with limited therapeutic options and a poor prognosis. We report the first dual-ligand hybrid solid lipid nanoparticle (HSLN) system for blood-brain barrier (BBB) penetration and targeted delivery of curcin, a type I ribosome-inactivati... |
41938524 | Non-Coding DNA-Derived Mimotopes of Aβ₄₂ as Novel Candidates for Alzheimer's Peptide Vaccine Design. | Alzheimer's disease (AD), the leading cause of dementia, is a progressive neurodegenerative disorder marked by memory loss, cognitive decline, and characteristic neuropathology involving amyloid-β (Aβ) plaques and tau tangles. Among emerging therapeutic strategies, Aβ-targeted immunotherapy using monoclonal antibodies ... |
41918920 | Aqueous Micellar-Catalyzed Thioetherification for the Synthesis of Aggregation-Induced Emission Molecules. | 1,1-Diphenylvinyl sulfide (DPVS) exhibits aggregation-induced emission (AIE) behavior by restricting intramolecular motion, making it a valuable aggregation-induced luminescent material. However, the synthesis of such AIE molecules typically involves organic sulfur reagents and toxic organic solvents, which limits thei... |
41901731 | <i>Elizabethkingia</i> Species as an Emerging Pathogen: A Comprehensive Review of Clinical and Microbiological Evidence. | <i>Elizabethkingia</i> species are rare but increasingly recognised Gram-negative pathogens linked to healthcare-associated transmission, intrinsic multidrug resistance, and severe infection in vulnerable hosts. We performed a comprehensive review of human <i>Elizabethkingia</i> infections by systematically searching P... |
41900812 | Next-Generation Minimally Invasive Anti-Aging Therapy: Incorporation of Resveratrol-Nicotinamide Cerosomes into PLGA Microneedles for Enhanced Skin Permeation. | <b>Background/Objectives</b>: Skin aging and wrinkle formation are primarily driven by ultraviolet (UV)-induced oxidative stress and inflammation. Resveratrol (RSV) and nicotinamide (NCT) possess potent anti-aging properties but suffer from poor skin penetration. This study aimed to develop an advanced transdermal deli... |
41898941 | Potential for Distribution Expansion of <i>Stephanitis chinensis</i> in China Based on MaxEnt Model. | The tea lace bug, <i>Stephanitis chinensis</i>, is an important pest in the southwest tea region in China. It has recently emerged in some parts of the tea areas, severely impacting the profitability of spring tea. To clarify the distribution dynamics of <i>S. chinensis</i> under current and future climate change, this... |
41897322 | Establishment and Maintenance of Repressed Chromatin States on Dosage-Compensated Sex Chromosomes. | Sex chromosome imbalance is a genetic challenge in species with unequal X-chromosome numbers. Organisms have developed distinct strategies to control this imbalance through a process called dosage compensation. These strategies include X-chromosome inactivation in mammals mediated by the XIST long noncoding RNA and pro... |
41892532 | Smart Hydrogel for the Treatment of Rheumatoid Arthritis. | Rheumatoid arthritis (RA) is a chronic autoimmune disease that imposes substantial physical, emotional, and socioeconomic burdens on patients. Conventional therapeutic approaches are often limited by systemic toxicity, inadequate joint targeting, and variable patient responses, highlighting the urgent need for advanced... |
41889780 | Deciphering How Clustered O‑Glycosylation Shapes Substrate-Binding Preferences in an Intrinsically Disordered Protein Region. | Post-translational modifications such as clustered O-glycosylation are frequently enriched in intrinsically disordered regions (IDRs), yet their roles in shaping molecular behavior and functional specificity remain poorly understood. Here, we addressed this challenge through an integrative, stepwise strategy that combi... |
41889736 | <i>Fusobacterium nucleatum</i> Lipopolysaccharides Disrupt the Interaction of Siglec‑7 to Sialoglycans Expressed on Mammalian Cells. | Sialic acid-binding immunoglobulin-like lectins (Siglecs) are key immune receptors that bind to cell surface sialic acids, leading to modulation of the immune system. Interrupting the Siglec-sialoglycan binding in cancer has been proposed as a potential antitumor response strategy. We previously showed that colon-cance... |
41884409 | Enantioselective Synthesis of Axially Chiral Spiro[3.3]heptanes by Site-Selective C-H Functionalization. | The enantioselective synthesis of axially chiral 2,6-disubstituted spiro[3.3]-heptanes is challenging because the differentiating functionalities are far apart from each other. The known enantioselective methods to generate these compounds have relied on the use of enzymatic processes. The current study achieves a high... |
41878148 | Extending the architecture of bolaamphiphilic disinfectants: an investigation of octenidine and isooctenidine analogs. | Quaternary ammonium compounds (QACs) have been used in commercial disinfectants since the mid-1900s due to their strong antimicrobial activity and relatively low toxicity to eukaryotic cells. However, antimicrobial resistance to common disinfectant compounds has compromised their effectiveness over the past decades. Th... |
41867596 | Recyclable Mn<sub>2</sub>O<sub>3</sub>@SiO<sub>2</sub> Nanocatalyst for Selective Mono-N-alkylation of Amines Utilizing a Borrowing-Hydrogen Approach. | Amines are structural motifs that are found naturally in a wide variety of products and are used as fundamental building blocks in the production of pharmaceuticals and agrochemicals. The creation of C-N bonds has evolved; among many synthetic approaches, the utilization of the hydrogen-borrowing strategy has emerged a... |
41867567 | Foam-Porous Alginate-Bentonite Beads Coated with Gamma-Irradiated Chitosan for Selective Chlorophyll Removal with Preservation of Plant Bioactives. | Excess chlorophyll in plant ethanol extracts can compromise analytical accuracy and restrict industrial applications in food, herbal, and cosmetic formulations. This study developed foam-porous alginate-bentonite beads coated with gamma-irradiated chitosan (FP-Alg/Bent-gCS) as a selective, reusable biocomposite adsorbe... |
41867552 | Near-Infrared-Responsive, Oxygen Self-Sufficient Nanoparticles for Combined Photothermal and Thermally Activated Photodynamic Therapy in Oxygen-Deficient Environments. | Hypoxia severely limits the efficacy of photodynamic therapy (PDT) because oxygen shortage suppresses the generation of cytotoxic reactive oxygen species (ROS). Here we report near-infrared (NIR)-responsive, oxygen self-sufficient nanoparticles (TANPs) that integrate photothermal therapy (PTT) with thermally activated,... |
41867539 | Thermocatalytic Transformation of Nitriles Utilizing Pristine and Calcined ZnCr Layered Double Hydroxides for the Synthesis of Various Tetrazole- and Kynurenic Acid-Based Drug Candidates. | For the first time, Zn/Cr-containing layered double hydroxides (LDH) and mixed metal oxides (MMO) were applied in the synthesis of 5-substituted 1<i>H</i>-tetrazole heterocycles from different aromatic nitriles and TMSN<sub>3</sub> (trimethylsilyl azide) as a less explosive/toxic and easily recoverable azide source. Ef... |
41867528 | Synthesis and Characterization of Solvent-Complexes of <i>per</i>-Hydroxy Pillar[5]arene and Pillar[5]quinone: Experimental and Computational Insights. | When the macrocycles <i>per-</i>hydroxy pillar[5]-arene (P[5]-A-OH) and pillar[5]-quinone (P[5]-Q) are recrystallized from suitable solvents like acetone and 1,1,2,2-tetrachloroethane (TCE), respectively, the solvent molecules form host-guest complexes in a 1:2 stoichiometric ratio. These complexes survive prolonged ex... |
41859660 | Wheat aroma biomarkers induced by saline-alkali soil: based on HS-SPME-GC-MS and molecular docking. | <h4>Background</h4>The precise volatile compounds accountable for the characteristic scent of the wheat aroma were presently unidentified. Given the prominent manifestation of "wheat aroma" in wheat cultivated in saline-alkali (SA) soil, five wheat varieties planted in saline-alkali soil and control soil (low saline-al... |
41859539 | The roles of salivary secretory IgA on the development of oral candidiasis. | Oral candidiasis, an opportunistic fungal infection mainly caused by <i>Candida albicans</i>, is highly prevalent in immunocompromised individuals. Saliva acts as the oral cavity's first line of defense, with secretory immunoglobulin A (sIgA) as its key specific immune component. In this review, we systematically clari... |
41859518 | Enantioselective synthesis of calix[4]arenes with C-C axial and inherent chirality <i>via</i> palladium/chiral norbornene cooperative catalysis. | The catalytic asymmetric synthesis of inherently chiral calix[4]arenes, a distinct class of chiral macrocycles with significant applications in asymmetric catalysis, chiral recognition and functional materials, remains a formidable challenge. Moreover, strategies for the simultaneous introduction of multiple stereogeni... |
41859463 | Current and emerging approaches to manage chronic inflammatory gut disorders. | Chronic inflammatory gastrointestinal disorders, including inflammatory bowel disease (IBD), Crohn's disease, ulcerative colitis, and irritable bowel syndrome (IBS), remain challenging to manage due to complex etiologies, heterogeneous disease progression, and limitations in current diagnostic and therapeutic strategie... |
41859462 | Intelligent <i>in-silico</i> prioritization of antimalarial peptide candidates under explicit physicochemical windows via <i>de novo</i> CTCM-Neo generation and conformal-gated calibrated classification. | <h4>Introduction</h4>Malaria remains a major global health burden and motivates fast, reliable in silico prioritization of antimalarial (AM) peptide candidates. Designing such peptides is challenging due to the vast search space, scarce or noisy supervision, and potential out-of-distribution miscalibration of computati... |
41859173 | Clinical characteristics and prognostic factors of <i>Clostridium perfringens</i> infection complicated by massive intravascular hemolysis in patients with hematologic diseases: a retrospective case series study. | Clostridium perfringens (CP), an anaerobic Gram-positive bacterium, is commonly associated with food poisoning and gas gangrene. In rare instances, it can cause fatal massive intravascular hemolysis (MIH), a condition associated with exceedingly high mortality that poses a serious clinical challenge. A retrospective an... |
41859161 | The lipid-podocyte axis: emerging clues in membranous nephropathy pathogenesis. | Membranous nephropathy (MN) is an immune-mediated glomerular disease and the most common cause of nephrotic syndrome in adults. Classical paradigms concentrate on the binding of circulating autoantibodies (e.g., anti-PLA2R, anti-THSD7A) to podocytes, resulting in subepithelial immune deposits, complement activation, an... |
41859118 | Mesenchymal stem cell-derived extracellular vesicles: emerging cell-free therapeutics for kidney diseases. | The increasing global impact of kidney diseases highlights a pressing and unmet need for new treatment strategies. In this context, mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have emerged as a promising cell-free therapeutic approach, attracting growing interest due to their dual regenerative functi... |
41859117 | isMap - immunological synapse map analysis program. | T cell activation is initiated when T cells recognize their cognate antigen on the surface of antigen presenting cells (APCs). This triggers formation of a specialized membrane interface termed the immunological synapse (IS) which governs the spatial organization of the intercellular protein interactions ultimately det... |
41859109 | Immunoreactivity of pan MHC-I epitopes on Crimean-Congo hemorrhagic fever virus glycoprotein C-terminal. | <h4>Introduction</h4>Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne pathogen causing severe hemorrhagic disease with high mortality. The viral glycoprotein Gc mediates membrane fusion and represents a key target of CD8⁺ T-cell responses. However, systematic identification and comprehensive evaluation of ... |
41859104 | Cloning, expression and characterisation of antigen-specific recombinant bat immunoglobulin from the black flying fox (<i>Pteropus alecto</i>). | Bats are natural reservoir of viruses that cause severe disease in livestock and humans. Recent high-profile spillover events have directed significant attention towards the relationship between zoonotic viruses and antiviral immunity inherent to bats. Studies have highlighted that bats could harbour some deadly viruse... |
41858994 | Acute effects of strength training interventions on subjective, neuromuscular, and biochemical fatigue parameters in elite youth soccer players. | This study examined acute neuromuscular, biochemical, and subjective fatigue responses to two strength training protocols-back squats with calf raises vs. back squats with plyometric exercises-in elite youth soccer players. The aim was to track the progression and resolution of fatigue over a 72 h recovery period and e... |
41858793 | Emerging pathological mechanisms of Alzheimer's disease pathogenesis: from neuroimmune interactions to intercellular communication. | Alzheimer's disease (AD) research has transcended the traditional paradigm centered on amyloid-beta (Aβ) shifting toward a neuroimmune network perspective. This article systematically elucidates the evolving mechanisms underlying disease progression, from neuroimmune interactions to intercellular communication. Studies... |
41858737 | Mitochondrial metabolism in cancer stem cells (CSCs): molecular and diagnostic implications. | Cancer stem cells (CSCs) are a self-renewing population often linked to tumor initiation, metastasis, relapse, and resistance to therapy. While bulk tumor cells are often dependent on glycolysis, CSCs demonstrate metabolic plasticity can switch between glycolysis and OXPHOS (oxidative phosphorylation) depending on cont... |
41858693 | Thermally tunable naphthalene diimide solvates enable selective sensing, reversible photochromism, and anti-counterfeiting applications. | Recent studies have highlighted the potential of naphthalene diimide (NDI)-based molecules for their stimuli-responsive and optical properties. In this work, we report two naphthalene diimide (NDI)-based solvates, designated as NDI-1 and NDI-2, were successfully synthesized from 4-aminopyridine and 1,4,5,8-naphthalene ... |
41858692 | Membrane-targeted schiff base derivatives overcome MRSA resistance through phosphatidylglycerol binding and ROS-mediated killing. | <h4>Introduction</h4>The urgent need for novel antibacterial agents against drug-resistant Gram-positive pathogens, particularly Methicillin-resistant Staphylococcus aureus (MRSA), drives this research. This study aimed to synthesize and evaluate a series of N'-substituted methylene-4-chlorobenzohydrazide derivatives a... |
41858671 | Optimized ridge-furrow ratio regulated soil nutrients, promoted grain filling and increased wheat yield. | <h4>Introduction</h4>The ridge-furrow planting system improves wheat grain filling and soil quality; however, the effects of appropriate ridge-furrow ratio on soil nutrient dynamics and nutrient-plant interaction and its potential response mechanism under ridge-furrow planting mode are still unclear. This study was des... |
41858663 | Natural products for biocontrol of <i>Pseudomonas syringae</i>: mechanisms and applications. | <i>Pseudomonas syringae</i> functions as a model phytopathogen causing numerous crop diseases, resulting in substantial economic losses in global agriculture. Presently, management of <i>P. syringae</i> predominantly depends on chemical pesticides; however, their prolonged application has contributed to escalating resi... |
41858662 | Harnessing plant lignin for sustainable materials and chemicals: integrating biosynthesis, structural diversity, and circular bioeconomy perspectives. | Lignin is the most abundant renewable source of aromatic carbon on Earth and a central yet historically underutilized component of lignocellulosic biomass. Its complex and heterogeneous molecular architecture has long constrained efficient and selective conversion into value-added products, despite its high aromatic ca... |
41858535 | Molecular epidemiology and genomic analysis of bulbul coronavirus in Guangdong, China. | <h4>Introduction</h4>Bulbul coronavirus (BuCoV), a delta coronavirus recently identified in passerine birds, remains poorly characterized regarding its ecology and evolutionary dynamics. This study aimed to determine the prevalence of BuCoV in wild avifauna, clarify its evolutionary relationship with other delta corona... |
41847254 | Unraveling the coordination isomerism by ligand hyperfine NMR shifts. | The hyperfine (Curie) NMR shifts of ligand atoms in open-shell coordination compounds report subtle details of the spin distribution around the central metal atom. In this work, we propose hyperfine NMR shifts as simple and extremely sensitive indicators of the ligand coordination geometry. This is demonstrated for equ... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.