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41677042 | Influence of nitrogen functional groups in carbon-based supports anchoring Pt nanoclusters and single atoms for efficient ammonia borane hydrolysis. | A Pt(II) precursor was impregnated onto graphite (C) and carbon nitride (CN<sub><i>x</i></sub>), successfully forming subnanometric Pt clusters and single atoms. The N species on CN<sub><i>x</i></sub> modified the electronic and topological structure of the metal, improving the catalytic properties of the Pt/CN<sub><i>... |
41674329 | High-throughput visual detection of multiple sweat biomarkers based on Au@Pt modified bimetallic MOF-derived nanozyme hydrogels. | Herein, we constructed a MOF-derived nanozyme with a hydrogel matrix-based colorimetric wearable sensor for the simultaneous detection of three representative sweat biomarkers: vitamin C, lactate, and uric acid. |
41670297 | A multifunctional core-shell CoFe<sub>2</sub>O<sub>4</sub>@ZIF-67 nanocomposite for simultaneous detection and removal of Pb<sup>2+</sup> in water. | To address the challenge of integrated detection and removal of toxic Pb<sup>2+</sup> from water, a novel magnetic core-shell nanocomposite, CoFe<sub>2</sub>O<sub>4</sub>@ZIF-67, was developed. This design synergistically combines the superparamagnetism of the CoFe<sub>2</sub>O<sub>4</sub> core for rapid separation wit... |
41670063 | Zn(II)-coordinated organic small molecule as a chiral fluorescent probe for discrimination and detection of tyrosine enantiomers. | Clamp-shaped chiral organic small molecules (COSM) are designed by linking one (1<i>R</i>,2<i>R</i>)-(+)-1,2-diphenyl-1,2-ethylenediamine molecule and two 5-methylsalicylic acid molecules <i>via</i> an amidation reaction. Aldehyde groups are introduced at positions <i>ortho</i> to the hydroxyl groups in the two 5-methy... |
41666411 | Ultrasensitive toltrazuril sulfone detection in eggs <i>via</i> a AuNPs/NH<sub>2</sub>-Ce-MOF-enhanced electrochemical immunosensor. | The widespread use of toltrazuril (TOL) as a low-toxicity anticoccidial agent in livestock production necessitates sensitive monitoring of its persistent metabolite, toltrazuril sulfone (TOS), which exhibits hepatotoxic and reproductive risks at subchronic exposure levels. Here, we proposed a novel electrochemical immu... |
41665257 | Pyrene-based fluorescent molecularly imprinted polymer for the rapid and selective detection of oxytetracycline based on the inner filter effect. | Oxytetracycline (OTC) residues seriously threaten human health, as they may trigger allergic responses, hepatotoxicity, and the development of bacterial resistance. Detecting OTC in samples is therefore important. This work developed a pyrene-based fluorescent molecularly imprinted polymer (Py-FMIP) for rapid and selec... |
41589745 | Metal-organic frameworks for the adsorption of alkali metal ions. | Highly efficient separation and recovery of alkali metal ions (<i>e.g.</i> lithium, sodium, potassium, rubidium, and cesium) from natural and artificial brines are urgent tasks because of the huge reserves of brines and their increasing demand in advanced industries. During the past twenty years, porous metal-organic f... |
41988074 | Liquid-liquid phase separation and its regulation of the BACH2 intrinsically disordered region. | Intrinsically disordered regions (IDRs) are vital for several cellular processes. They play a significant role in liquid-liquid phase separation (LLPS). LLPS enhances reaction efficiency by locally concentrating proteins and nucleic acids. The BACH2 transcription factor contains such IDRs. Early observations hinted at ... |
41948465 | Self-reinforcing nanoplatform uniting pemetrexed, magnetic hyperthermia and PD-L1 blockade reshapes the tumor microenvironment and elicits combined antitumor immunity in lung adenocarcinoma. | Lung cancer remains the leading cause of cancer-related mortality worldwide, and immune checkpoint blockade is often limited by an immunosuppressive tumor microenvironment (TME). To address these challenges, we developed a novel multifunctional nanoplatform, based on a mesoporous Fe<sub>3</sub>O<sub>4</sub> core and si... |
41943366 | Construction of an ultra-sensitive surface-enhanced Raman spectroscopy substrate based on a water-stable cross-linked cyclodextrin metal-organic framework. | Surface-enhanced Raman spectroscopy (SERS) substrates based on gold nanoparticles (AuNPs) typically suffer from limited enhancement efficiency due to random AuNPs aggregation. This aggregation issue, however, can be resolved by synthesizing AuNPs using cyclodextrin metal-organic framework (CD-MOF) as a structural templ... |
41918923 | Structure-Dependent Formation of HFC-125a/CO<sub>2</sub> Mixed Hydrates: Raman Evidence and Implications for Fire Suppression. | Mixed gas hydrates containing 1,1,1,2,2-pentafluoroethane (HFC-125a) and carbon dioxide (CO<sub>2</sub>) have emerged as promising candidates for next-generation fire suppression due to their combined cooling and capabilities. In this study, the formation behavior, hydrate yield, thermodynamic characteristics, and mole... |
41901203 | Silver-<i>N</i>-Heterocyclic Complexes Against <i>Leishmania major</i>: In Vitro, In Vivo and In Silico Therapeutic Activities. | <b>Background</b>/<b>Objectives</b>: Cutaneous leishmaniasis (CL) is a prevalent vector-borne disease characterized by a broad spectrum of clinical manifestations resulting from protozoan parasites belonging to the genus <i>Leishmania</i>. The challenges associated with the treatment of CL are attributable to various f... |
41900892 | Metabolites from South African Medicinal Plants as Dual-Function Inhibitors of the SARS-CoV-2 Papain-like Protease (PL<sup>pro</sup>). | The SARS-CoV-2 papain-like protease (PL<sup>pro</sup>) is an essential viral enzyme that promotes viral polyprotein processing while simultaneously suppressing the host innate immune response, which makes it a primary target for developing antiviral drugs. The present study employs a comprehensive approach integrating ... |
41900165 | Advances in 3D Bioprinting: Materials, Processes, and Emerging Applications. | Three-dimensional (3D) bioprinting has rapidly emerged as a transformative technology at the interface of biomedical engineering and regenerative medicine. By enabling the spatially controlled deposition of living cells, biomaterials, and bioactive molecules, it offers an unprecedented potential to fabricate functional... |
41900169 | Overview in Machine-Learning-Assisted Sensing Techniques for Monitoring COVID-19. | Viruses suddenly emerging from obscurity or anonymity affect our quality of life and increase incidence rate and mortality. A typical example is the global coronavirus disease 2019 (COVID-19) pandemic. Although severe acute respiratory syndrome coronavirus 2, known as the pathogen of COVID-19 has been significantly eli... |
41897432 | Mitochondrial Stress in <i>Helicobacter pylori</i> Infection and Associated Malignancies: A Review. | <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection is one of the most common bacterial infections worldwide. Its role in infection-associated cancers, such as gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma is well known. However, mitochondrial alterations in these malignancies are less docume... |
41892826 | Immunotherapies for Ischemic Stroke Patients: Current Status and Future Directions. | <h4>Background/objectives</h4>Ischemic stroke occurs when a thrombus forms within a blood vessel in the brain. This results in reduced levels of oxygen and glucose, leading to the death of cells and a reduction in function. There are several molecular signaling cascades that commence after the onset of an ischemic stro... |
41892514 | Injectable Thermosensitive Composite Hydrogels for Sustained Nanoparticle Delivery and Enhanced Wound Healing. | Wound healing is frequently compromised by excessive oxidative stress, prolonged inflammation, and inadequate tissue regenerative capacity. To address these challenges, a thermosensitive and injectable composite hydrogel based on Pluronic F127 (F127), phosphatidylcholine (PC), and L-lysine (Lys) was developed for the s... |
41889740 | Solvent Reorganization in Stabilized Protein-Polymer Conjugates Visualized by Two-Dimensional Infrared and Nuclear Magnetic Resonance Spectroscopy. | PEGylation is essential for the effective function of biologics, shielding them from rapid degradation and clearance in the complex environment of the human body. Despite its significance, a mechanistic understanding of PEGylation's role in enhancing protein stability is incomplete, limiting the ability to design PEGyl... |
41835600 | Integrating Molecular Modeling and Nanoemulsion Characterization for Ibuprofen. | Ibuprofen (IBU), a widely used nonsteroidal anti-inflammatory drug, exhibits low aqueous solubility and polymorphic behavior, which can compromise its bioavailability and pharmaceutical performance. This study investigated the structural, electronic, and supramolecular properties of two polymorphic forms of IBU and ass... |
41835601 | Construction of a Portable Colorimetric Biosensing Platform Based on the Co-TCPP (Fe)-MOF Nanosheet and Its Application in Glucose Detection. | Recent advancements in microfluidic paper-based analytical devices (μPADs) have demonstrated their significant potential for point-of-care testing (POCT), particularly in low-resource settings. These devices are especially promising for monitoring glucose levels in patients with diabetes, offering a cost-effective and ... |
41835544 | Fragment-Based Online OzESI-MS, NMR, and Computational DP4+/DFT Approaches to the Characterization of the Putative Biosynthetic Lipid Precursor of Atkamine from Alaskan <i>Latrunculia</i> Sponges. | The extraction of <i>Latrunculia</i> sponges collected along the coast of the Aleutian Islands of Alaska yielded a lipid fraction, in which a natural long-chain monounsaturated aldehyde, (<i>Z</i>)-docos-15-enal (<b>1</b>), was isolated for the first time from this genus of sponge. Experimental, DP4+/DFT structure-prob... |
41829250 | Carboxymethyl Cellulose-Based Films for Sustainable Food Packaging: Modification Strategies and Structure-Property Relationships. | The growing environmental impact of petroleum-based plastics has intensified research into sustainable, biodegradable alternatives for food packaging. Among bio-derived polymers, carboxymethyl cellulose (CMC) has attracted increasing attention due to its abundance, non-toxicity, biodegradability, and excellent film-for... |
41828761 | ZIF-9-Derived Cobalt and Nitrogen-Doped Carbon Nanocomposites for Sensitive Electrochemical Nitrite Determination. | The accurate monitoring of nitrite levels is critically important for safeguarding public health and ensuring food safety, as excessive intake presents severe risks. In this study, we developed a highly sensitive electrochemical sensor for nitrite detection utilizing a cobalt-embedded porous carbon material derived fro... |
41828376 | Potassium Hexafluoroacetylacetonate Complex with 18-Crown-6 Ether as a Volatile Precursor of Molecular and Inorganic Films: Thermal and Structural Insights. | Volatile coordination compounds are widely used as precursors for the gas phase synthesis of functional materials. However, such complexes are still very rare for alkali metals, especially for heavy representatives of this family (potassium, rubidium, cesium) due to the tendency to form polymeric structures. This work ... |
41828354 | Physiological and Molecular Mechanisms of Nitrogen Regulation on Grain Quality in Cereal Crops at Later Stages. | Enhancing cereal grain quality while maintaining yield stability represents a pressing global challenge for sustainable agricultural development. Optimizing grain quality in cereal crops, which account for more than 60% of global dietary energy, relies heavily on managing nitrogen dynamics during the heading and grain-... |
41823745 | Composition and Structural Design of Magnetic Alloy/Composites for High-Performance Microwave Absorption: A Review. | Magnetic metals are of considerable importance for stealth technology and electromagnetic pollution control. However, they suffer from inherent limitations, such as the Snoek limit and narrow absorption bandwidth, which restrict their applications in complex scenarios. To address these challenges, this review systemati... |
41821879 | Unveiling the hidden regulators: how post-translational modifications influence the progression and treatment of hepatocellular carcinoma. | Hepatocellular carcinoma (HCC) is a common and aggressive primary liver cancer. Due to its high incidence and fatality rates, it poses a serious threat to global public health. Protein post-translational modifications (PTMs) are crucial regulatory mechanisms that occur after translation and fine-tune cellular functions... |
41821882 | The structure and functions of TRAF families and recent advances of TRAFs in leukemia. | Leukemia is a malignant clonal disease of hematopoietic stem cells. Currently, primary treatments include chemotherapy, targeted drugs, hematopoietic stem cell transplantation, and immunotherapy. Although advances in treatment have improved survival for leukemia patients, treatment failure still occurs in some individu... |
41821854 | Microbiome-mycotoxin interactions and probiotic strategies: implications for gut health and cancer. | This structured, hypothesis-driven narrative review examines how mycotoxins, pervasive food contaminants, disrupt intestinal microbial balance, epithelial barrier integrity, xenobiotic metabolism, and carcinogenic signaling. Emerging evidence indicates that bidirectional interactions between the gut microbiome and myco... |
41821610 | Systems-level actions of luteolin in female reproductive disorders: from molecular mechanisms to clinical translation. | Female reproductive disorders represent a major global health challenge. Despite their clinical heterogeneity, these conditions share core pathological mechanisms including oxidative stress, chronic inflammation, hormonal imbalance, metabolic dysfunction, extracellular matrix remodeling, and dysregulated cell survival.... |
41822520 | The SIRP family: from structural diversity and signaling mechanisms to implications in immune-related disease targeted therapeutics. | Signal regulatory proteins (SIRPs) are membrane receptors on immune cells that control immune homeostasis and inflammation. Although SIRP family members share homologous extracellular domains, they differ in intracellular motifs and function: SIRPα transduces inhibitory signals, SIRPβ associates with DAP12 to trigger a... |
41822516 | The emerging role of histone acetylation in rheumatic diseases: unraveling mechanisms and therapeutic prospects. | Histone acetylation, a fundamental and reversible epigenetic modification, critically regulates chromatin structure and plays a pivotal role in diverse cellular processes, including gene transcription, cell cycle progression, and DNA damage repair. Rheumatic diseases [such as rheumatoid arthritis (RA), osteoarthritis (... |
41822379 | Bisarylthiourea comprising cycloalkyl-thiophene-3-carboxylate derivatives as potential human toll-like receptor (TLR2) agonists: design, synthesis, and structure-activity relationship enabling the switch from TLR2/1 to TLR2/6 activation. | Toll-like receptor 2 (TLR2) acts as a pivotal family of pattern-recognition receptors that bridges innate and adaptive immunity through the detection of PAMPs and DAMPs. In pursuit of novel immunomodulators, a series of bisarylthiourea (BAT) comprising cycloalkyl-thiophene-3-carboxylate derivatives was rationally desig... |
41822378 | 1,3,4-Oxadiazole derivatives: targeting multiple bacterial pathways. | Antimicrobial resistance (AMR) has emerged as a major worldwide issue in the effective management of infectious diseases. This problem prompted researchers worldwide to develop new therapeutic agents that target both well-established and novel biological pathways. Among numerous heterocyclic frameworks, 1,3,4-oxadiazol... |
41822307 | Enhanced banana productivity, soil microbial community structure, and <i>Fusarium</i> wilt resistance by ultra-wide-narrow row planting pattern. | The sustainability of banana production is severely constrained by labor intensiveness, <i>Fusarium</i> wilt epidemics, and mechanization incompatibility under conventional planting systems. A three-year (2019-2021) investigation systematically evaluated three distinct planting configurations for simultaneously address... |
41822220 | Genetic variability and phylogenetic analysis of the VP2 gene of feline parvovirus in Harbin. | <h4>Introduction</h4>In 2023, a total of 450 fecal samples were collected from healthy cats and those suspected of being infected with Feline Panleukopenia Virus (FPV) in Harbin, China.<h4>Methods</h4>The FPV VP2 gene was detected using polymerase chain reaction (PCR). Positive samples were then subjected to VP2 sequen... |
41822029 | Multidimensional mechanisms of quercetin in diabetic kidney disease. | Quercetin is a flavonoid compound that has demonstrated substantial potential in the treatment of diabetic kidney disease (DKD). However, there is still a lack of systematic research on the exact mechanism of action of quercetin. This review discusses the druggability, molecular targets, and signaling pathways of querc... |
41816117 | Local Environmental Effects on Light-Driven CO<sub>2</sub> Reduction in Liposomes. | We report the governing principles that regulate the activity of light-driven CO<sub>2</sub> reduction by a molecular photosensitizer bis-(2,2'-bipyridine)-(4,4'-dinonyl-2,2'-bipyridine)-ruthenium-(II) (<b>RuC</b> <sub><b>9</b></sub> ) and a molecular catalyst (5,10,15,20-tetra-(4-methylphenyl)-porphinato)-cobalt-(II) ... |
41815940 | A novel epigenetic regulation of JAM-A by EZH2-DNMT3A cascade contributes to T cell adhesion via the activation of Rap1a in lupus patients. | <h4>Objectives</h4>The peripheral blood T cells epigenetic modification and adhesion capacity alterations are the characteristic of SLE. EZH2 induces proinflammatory epigenetic changes in immune regulation. JAM-A widely involves in cell adhesion. However, the molecular regulation mechanisms between EZH2 and JAM-A in T ... |
41809377 | XN@CuO/HA nanobipyramids trigger FOXO1-GADD45G-mediated cuproptosis and synergy with anti-PD-1 for lung cancer therapy. | Lung cancer is a leading cause of cancer-related mortality, with current therapies limited by drug resistance and immunosuppressive tumor microenvironment (TME). Cuproptosis offers new therapeutic prospects, but effective induction and targeted delivery remain challenging. Herein, we developed xanthohumol (XN)-coordina... |
41800457 | Carrier-free supramolecular architectonics of quercetin<b>-</b>berberine for safety-redefined therapy of ulcerative colitis. | Ulcerative colitis (UC) poses significant clinical management challenges due to the limited efficacy and substantial safety burdens of existing treatments. This study develops a carrier-free supramolecular nanoassembly (QB) composed solely of quercetin (QU) and berberine (BBR), reshaping the safety-efficacy profile of ... |
41799255 | Copigmentation of procyanidin dimers with malvidin-3-<i>O</i>-glucoside: Impacts on color and stability in model wine. | This study investigated the impacts of procyanidins B1 and B2, the predominant dimeric proanthocyanidins in red wine, on anthocyanin color and stability. A combination of spectrophotometry, thermodynamic analysis, time-dependent density functional theory calculations, and UHPLC-Q-TOF-MS was used. It was demonstrated th... |
41795365 | Dual-interface regulation of two-dimensional ZIF-based composite membranes for efficient and stable pervaporation desalination. | Highly permselective and stable membranes are crucial to promoting the large-scale application of pervaporation (PV) in desalination. Despite the metal-organic frameworks (MOFs)-polymer composite membranes have demonstrated application potential, their desalination performance and structural stability remain constraine... |
41789358 | A suite of macrocyclic peptide inhibitors and substrate probes for arginine methyltransferases. | Arginine methyltransferases (PRMTs) are key regulators of chromatin structure, RNA processing, and signal transduction, and their dysregulation has been linked to cancer and other diseases. The development of potent and selective chemical probes for individual PRMTs remains a major challenge. Here we report a discovery... |
41783155 | Programmable spatiotemporal control of CRISPR-Cas12a: Engineering precision for next-generation gene editing and diagnostics. | CRISPR-Cas12a has emerged as a versatile alternative to Cas9, offering distinct advantages, such as recognition of thymine-rich protospacer adjacent motifs, generation of staggered 5' DNA breaks, simplified guide RNA architecture, and collateral (trans) single-stranded DNA cleavage. These features have enabled applicat... |
41777376 | Current Advancements in the Arsenal for Spinal Cord Injury Repair: Novel Drug Formulations. | Spinal cord injury (SCI) is a devastating condition associated with high rates of disability and mortality, as well as a significant financial burden. The current clinical interventions have limited therapeutic effectiveness, primarily due to relentless secondary injury cascades and the inherent challenge of neuronal c... |
41777377 | Astragalus Polysaccharide Nanoparticles Alleviate Sepsis-Induced Myocardial Injury by Targeting the HSP90AA1/NLRP3 Signaling Pathway. | <h4>Purpose</h4>This study aimed to investigate the mechanisms by which Astragalus polysaccharide nanoparticles (APS-CS/TPP) protect against septic myocardial injury, addressing the limited understanding of how APS-CS/TPP specific signaling pathways in this condition.<h4>Materials and methods</h4>Potential targets and ... |
41777234 | Electrosynthetic access to unsymmetrical oxaza[8]helicenes with high chiral stability and strong circularly polarized luminescence (CPL). | Heterohelicenes are compelling chiral π-conjugated scaffolds for optoelectronic and chiral-photonic technologies because their helical frameworks and doped heteroatoms endow them with various photophysical, chiroptical, and electronic merits. However, unsymmetrical heterohelicenes remain rare, as their synthesis is oft... |
41771221 | Green MW/US route from lignocellulose to FDCA-based thiadiazol scaffolds: DPP-4/COX-1 inhibition and antioxidant evaluation. | The widespread use of lignocellulosic biomass has enabled the rapid conversion of lignocellulosic biomass to 2,5-dicarboxylic acid (FDCA), derived from thiadiazol/cyclamide scaffolds, using a combination of microwave/ultrasonic (MW/US) activation and depolymerization methods for the fabrication of these products. Acid-... |
41769172 | Bimetallic Au-Ag Nanoclusters as a Photo-Responsive Oxidase-Like Nanozyme for Antioxidant Detection and Intracellular Redox Analysis. | Bimetallic nanoclusters (NCs) hold promise as catalytic materials, yet their potential as enzyme mimics remains largely unexplored. Here, we report the first demonstration that gold-silver nanoclusters (AuAgNCs) function as photo-responsive oxidase-like nanozymes. Under visible-light irradiation, AuAgNCs catalyze thiam... |
41759847 | Multifunctional carboxymethyl chitosan-based supramolecular-polymeric hydrogel with integrated antibacterial and anti-inflammatory activities for accelerated wound healing. | Skin is vulnerable to injuries that can lead to bacterial infection and prolonged inflammation, impeding the healing process. To address this, we developed an antibacterial and anti-inflammatory supramolecular-polymeric composite hydrogel for accelerated wound healing. The hydrogel is formed by integrating paromomycin ... |
41759740 | Full-length tau seeded by C-shaped tau fibrils is conformationally variable. | A number of neurodegenerative amyloid proteins have been found to adopt disease-specific structures in the human brain. This prion-like propagation of the amyloid structure requires recruitment of soluble monomers containing various posttranslational modifications to adopt the same structure as the fibril seeds. To und... |
41757312 | Efficient inactivation of <i>Microcystis aeruginosa</i> by carbon microtube-supported magnetic photocatalysts under visible light. | The increasing influx of nutrients (<i>e.g.</i>, nitrogen and phosphorus) into freshwater systems is exacerbating eutrophication in natural waterways. To address this issue, a novel magnetic photocatalyst composed of a carbon nanotube core and a titanium dioxide coating (denoted as C-TiO<sub>2</sub>-Fe<sub>3</sub>O<sub... |
41757309 | Fluorescence and phosphorescence of tetracarboxylated ZnPc-perylene diimide organic systems in highly acidic media. | This study presents a comprehensive analysis of the photophysicochemical properties of zinc(ii) 2,9,16,23-tetracarboxy-phthalocyanine (TcPcZn), <i>N</i>,<i>N</i>'-bis(3-pentyl)perylene-3,4,9,10-bis(dicarboximide) (EP-PDI), and their mixed systems in various TFA/H<sub>2</sub>O solvent mixtures. Key aspects discussed inc... |
41757305 | Exploring the anti-diabetic potential of bis-Schiff bases of ibuprofen: insights into the <i>in vitro</i>, molecular docking and density functional theory analyses. | Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycaemia resulting from defects in insulin action or secretion. The synthesized bis-Schiff base derivatives of ibuprofen were evaluated for their <i>in vitro</i> α-amylase and α-glucosidase inhibitory activities using acarbose as a standard. Six c... |
41757304 | Durable and breathable EMI shielding spacer fabrics enabled by synergistic thiol and TPU coatings. | The proliferation of high-power electronics and 5G technology has created an increasing demand for high-performance electromagnetic interference (EMI) shielding materials that are durable, breathable, and comfortable for wearable applications. Although silver-coated textiles offer excellent shielding, their limited dur... |
41756722 | Atomic-Shell Engineering of GeS<sub>x</sub>-Au Nanorods Synergistically Suppresses Phonon Scattering and Activates N<sub>2</sub> for Near-Infrared-Driven Ammonia Synthesis. | The efficient utilization of near-infrared (NIR) light remains a paramount challenge for solar-driven photocatalytic nitrogen fixation, primarily due to rapid energy dissipation of hot carriers via phonon scattering. Here, we construct a well-defined core-shell heterostructure through the in situ anchoring of an ultrat... |
41756720 | Methanesulfonate in Phosphate Electrolyte Superstructure Enables Ampere-Hour Practical Aqueous Batteries. | Present high-voltage Li-ion aqueous batteries largely rely on highly concentrated (up to 63 <i>m</i>) "water-in-salt" electrolyte with limited cycle life (<1,000 cycles) and little hope in practical application. To date, no dilute aqueous electrolyte (salt molality < 2 <i>m</i>) can reliably operate beyond 2 V with cyc... |
41756718 | <i>SiLNR1</i>-Mediated Nitrogen Regulatory Signaling Enhances Nitrogen Use Efficiency and Grain Yield in Foxtail Millet (<i>Setaria italica</i> L.) under Low-Nitrogen Stress. | Foxtail millet (<i>Setaria italica</i> L.), a C4 cereal crop domesticated in China, exhibits exceptional nitrogen use efficiency (NUtE) with marked genotypic variation; however, the molecular basis remains underexplored. Here, we identified candidate genes through a sequential filtering strategy from genetic linkage (b... |
41756724 | A "Detachable Polyanionic Protective Shell" Enveloping Photodynamic Cationic Nanoassemblies for Keratitis Treatment. | Bacterial keratitis is a rapidly progressive, invasive corneal infection, necessitating the urgent development of more effective antibacterial therapies. Cationic polymers, which exert bactericidal effects by disrupting bacterial membranes, represent a promising candidate; however, their clinical application is limited... |
41749438 | Chinese Herbal Medicine Targets Gut Microbiota to Combat Neurodegenerative Diseases: Potential Mechanisms and Clinical Implications. | Due to the aging of the population, neurodegenerative diseases (NDs) have gradually become a major public health problem worldwide. Accumulating evidence has demonstrated that the gut microbiota and its metabolites were closely related to the occurrence and development of NDs. At present, Chinese herbal medicine (CHM) ... |
41747717 | Structural basis for sialoglycan recognition by the immune inhibitory receptor Siglec-10. | Sialic acid-binding immunoglobulin-like lectin 10 (Siglec-10) inhibits immune cell function by sensing the presence of sialylated glycoproteins. Here, we determined structures of Siglec-10 bound to sialyllactose (SL) ligands to visualize the molecular recognition events underlying Siglec-10 signaling. The structures re... |
41747701 | Post-imprinting modification of molecularly imprinted polymers for ultrasensitive screening chloramphenicol type antibiotics and risk assessment in urban environmental water. | Chloramphenicol antibiotics (CAs) are widely utilized for their remarkable therapeutic efficacy against bacterial infections. Antibiotics that are not metabolized by organisms pose a risk of developing antibiotic resistance genes and resistant bacteria when they enter the environment. Therefore, the development of high... |
41747367 | Mesoporous Bioactive Glass: Preparation, Characterisation, and Emerging Applications in Regenerative Medicine and Dentistry. | <h4>Introduction and aims</h4>Mesoporous bioactive glasses have emerged as advanced biomaterials due to their highly ordered mesoporous structure, large surface area, and enhanced biological reactivity. These properties distinguish them from conventional bioactive glasses and underpin their growing interest in regenera... |
41742756 | pH-Responsive Supramolecular System for Activation of Cellular Calcium Channels. | Ion channels play essential roles in cellular signaling, yet achieving precise, on-demand activation within the tumor microenvironment (TME) remains challenging. In this study, we develop a pH-responsive supramolecular assembly composed of a water-soluble cationic oligophenylenevinylene derivative (OPV-hex) and an acid... |
41742728 | Achieving High-Performance Multi-Resonance Thermally Activated Delayed Fluorescence (MR-TADF) Blue Emitter Using Benzothiophene Heterocyclic Fusion Strategy. | To meet the growing demands in the field of ultra-high-definition display, multi-resonance thermally activated delayed fluorescence (MR-TADF) materials have attracted extensive attention due to their narrowband emission characteristics. However, the development of these materials still faces many challenges, such as li... |
41742725 | Built-In Electric Field-Assisted Enzyme Catalytic Amplification with ZnO/CIS Heterojunctions for Photoelectrochemical Immunoassay. | This study presents a ZnO/CdIn<sub>2</sub>S<sub>4</sub> (ZnO/CIS) heterojunction-based photoelectrochemical immunosensor for sensitive prostate-specific antigen (PSA) detection. The separation and directional transport of photogenerated charge carriers are enhanced by the built-in electric field at the heterojunction i... |
41742712 | BOLL-Containing Aggregates Mediate the Translational Regulation During Human Oogenesis. | Human oocyte meiosis utilises a specialised translational control strategy to coordinate meiotic progression, mediated through dynamic regulation of mRNA stores. While germ cell-specific RNA-binding proteins (RBPs) are known to orchestrate this post-transcriptional programme, the mechanistic basis of RBP-mediated cell ... |
41742634 | Controlled Delivery and Light-Induced Release of Magic Spot Nucleotides in Escherichia coli. | The "magic spot" nucleotides (MSNs) ppGpp and pppGpp constitute bacterial alarmones that orchestrate the conserved stringent response, a global regulatory mechanism enabling bacteria to adapt to nutrient deprivation and other environmental stresses. Current strategies to manipulate MSN levels rely mainly on genetic or ... |
41742633 | Covalent-Coordination-Dual-Driven <i>In Situ</i> Modular Assembly of 12-Connected Nickel-Based Metal-Organic Frameworks. | The practical application of metal-organic frameworks (MOFs) is often hindered by the trade-off among structural stability, synthetic complexity, and functional tunability. Herein, we present a facile <i>in situ</i> modular assembly of highly stable 12-connected Ni<sub>8</sub>-MOFs by integrating the formation of coval... |
41742445 | Unlocking the "undruggable": current landscape and emerging frontiers in lysosomal receptor-mediated protein degradation. | Extracellular and membrane-associated proteins are essential in signal transmission, immunological control, and disease pathogenesis; nonetheless, their 'undruggable' characteristics have historically impeded drug discovery. The targeted protein degradation (TPD) technologies provide innovative solutions to address thi... |
41742312 | Highly fluorescent method for ultra-sensitive estimation of delafloxacin in human plasma: greenness assessment. | A simple, rapid, sensitive, and reliable spectrofluorimetric approach has been developed for the analysis of delafloxacin (DEL) in human plasma. The proposed method is based on the formation of a micellar fluorescent complex through the interaction of DEL with 2% sodium dodecyl sulfate (SDS) using a phosphate buffer (p... |
41742243 | Lock-equipped six-helix DNA bundle-mediated siSTING delivery ameliorates Alzheimer's disease via cGAS-STING inhibition. | Alzheimer's disease (AD) pathological progression is intimately linked to microglial inflammatory activation mediated by the cGAS-STING pathway. Small interfering RNA targeting STING (siSTING) is a precise therapeutic to silence STING and interfere with this pathway, but its clinical translation is severely limited by ... |
41741953 | Photochemical CO<sub>2</sub> Reduction Using a Ir(III)-Rh(III) Supramolecular Photocatalyst. | There is immense scope and interest in the development of photocatalytic CO<sub>2</sub> conversion. We have successfully developed a new supramolecular photocatalyst (<b>Ir-Rh</b>) in which the <b>Ir(III)</b> complex [Ir(piq)<sub>2</sub>(BL)]<sup>+</sup> (piq = 1-phenylisoquinoline, BL = 1,2-bis(4'-methyl[2,2'-bipyridi... |
41741779 | Robust triboelectric energy harvesters engineered from electrochemically deposited films of HKUST-1 polycrystals. | Triboelectric nanogenerators (TENGs) offer a potential power source for compact electronics and self-powered portable devices, with increasing interest in integrating metal-organic frameworks (MOFs) due to their tunable physical and chemical properties. However, the direct incorporation of MOF powders in TENG is hinder... |
41741668 | Clemizole inhibits CrtN-driven staphyloxanthin biosynthesis in Staphylococcus aureus to enhance host immune clearance. | The growing threat of Staphylococcus aureus, including methicillin resistant strains, calls for therapies that disarm virulence. Staphyloxanthin, a carotenoid pigment, protects S. aureus from oxidative killing and supports immune evasion. Here we identify clemizole, an FDA approved antihistamine, as a direct inhibitor ... |
41741647 | Peripheral immune-inducer dendritic cells drive early-life allergic inflammation. | Atopic diseases associated with allergens, as well as allergic diseases, frequently arise early in life; however, the age-dependent mechanisms governing immune responses to allergens remain poorly understood<sup>1</sup>. Here we find that in early life, exposure to common allergens triggers a distinct bifurcated immune... |
41741644 | Coral microbiomes as reservoirs of unknown genomic and biosynthetic diversity. | Coral reefs are marine biodiversity hotspots that provide a wide range of ecosystem services<sup>1</sup>. They are reservoirs of bioactive metabolites, many produced by microorganisms associated with reef invertebrate hosts<sup>2</sup>. However, for the keystone species of coral reefs-the reef-building corals-we still ... |
41741636 | CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly. | Imbalances in lipid storage and secretion lead to hepatic steatosis, the accumulation of lipid droplets in hepatocytes<sup>1,2</sup>. Our understanding of the mechanisms that govern the channelling of neutral lipids in hepatocytes towards cytosolic lipid droplets or secreted lipoproteins remains incomplete<sup>3,4</sup... |
41741583 | In-situ growth of heterogeneous Au on MoS<sub>2</sub> nanosheets for SERS detection of breast cancer-derived miR-210-3p and miR-9-3p. | In-situ growth of gold nanoparticles (AuNPs) on two-dimensional materials has emerged as a promising route to engineer broadband and tunable surface-enhanced Raman scattering (SERS)-based platforms. Here, we demonstrate the synthesis of heterogeneous AuNPs directly on MoS₂ nanosheets to construct a versatile, low-energ... |
41741523 | INHBA: a mitochondrial-related pan-cell death gene associated with the prognosis and immunity of OSCC. | Oral squamous cell carcinoma (OSCC) is a malignant tumor characterized by both clinical and molecular heterogeneity. Its rising global incidence and mortality rates pose considerable clinical challenges. Accumulating evidence suggests that dysregulation of mitochondria-associated pan-cell death, a process integrating m... |
41741464 | Responsive interlayer spacing in staggered metal-organic framework nanosheet membranes. | Precise control over the stacking of two-dimensional (2D) metal-organic framework (MOF) nanosheets enables the fabrication of MOF films or membranes with adjustable interlayer spacing and/or pore size, offering great potential for numerous applications, yet remains highly challenging. We herein propose a postsynthetic ... |
41741454 | Eliminating the negative pore synergy in hierarchical porous metal-organic frameworks for isomer separation. | Hierarchical porous metal-organic frameworks (MOFs) integrating micro- and mesopores hold promise for advanced separations but often suffer from understudied negative pore synergy, where interconnected pores compromise selectivity and diffusion. Using the zirconium-based porous coordination network (PCN) PCN-608 as a m... |
41741446 | Structural and functional implications of phase separation of membrane protein LacY in Escherichia coli. | Liquid-liquid phase-separation (LLPS) controls protein activity and dynamically organizes (macro)molecules in living systems without the need for membrane-bound compartments. Biomolecular condensates of water-soluble proteins have extensively been studied, but little is known about LLPS of membrane proteins. In this wo... |
41741428 | A gated hydrophobic funnel within BAX binds bioactive lipids to potentiate pro-apoptotic function. | Mitochondria maintain a distinct biochemical environment that cooperates with pro-apoptotic BAX and BH3‑only proteins (e.g., BIM) to promote mitochondrial outer membrane permeabilization (MOMP), the key event to initiate physiological and pharmacological forms of apoptosis. The sphingosine-1-phosphate metabolite 2-tran... |
41741351 | Insights into Adsorbate-Induced Dynamic Structures and Catalytic Microenvironments of Zeolite Acid Sites via Solid-State NMR. | Zeolites are essential solid acid catalysts whose catalytic performance is determined by the nature of their acid sites. Conventionally, these sites are viewed as static, predetermined structural motifs, characterized by metrics such as acid type (Brønsted/Lewis), strength, and spatial distribution within a rigid frame... |
41745645 | RETRACTED: Ullah et al. Fluorescent and Phosphorescent Nitrogen-Containing Heterocycles and Crown Ethers: Biological and Pharmaceutical Applications. <i>Molecules</i> 2022, <i>27</i>, 6631. | The journal retracts the article titled "Fluorescent and Phosphorescent Nitrogen-Containing Heterocycles and Crown Ethers: Biological and Pharmaceutical Applications" [...]. |
41740183 | Superprotonic Mixed Matrix Membranes Based on Anionic MOFs Containing Dimethylammonium Cations for Sustainable Energy Devices. | High proton conductivity and structural robustness are critical for advancing proton exchange membrane fuel cells (PEMFCs) in sustainable energy technologies. Here, we present a pH-controlled synthetic strategy that yields two cadmium-based metal-organic frameworks (MOFs), Cd-FAIA-1 (neutral) and Cd-FAIA-2 (anionic), b... |
41740004 | A Mitochondria-Specific Nanomedicine for Synergistic Chemo-Photothermal Therapy and Immunogenic Activation Against Breast Cancer. | The presence of "cold" tumors in the tumor site is characterized with poor immune cell infiltration and resistance to conventional cancer therapies. To address these challenges, we developed an amphiphilic peptide dendrimer-based multifunctional drug delivery system for integrating photothermal therapy (PTT), chemother... |
41739969 | Conformational Flexibility of Transmembrane Helices: How it Works and Where it Matters. | An increasing number of multipass and oligomeric membrane proteins is found to exist in different structural substates that represent different stages of their functional cycles. Many of their constituent transmembrane helices locally deviate from canonical α-helical structure, suggesting that their conformational flex... |
41739939 | DNA framework-based molecular transformer for logic-driven precision diagnostics. | Precision diagnostics requires logical integration of diverse biomarker information, but molecular heterogeneity and inconsistent identification kinetics hinder robust logic analysis. To overcome this, we develop a universal molecular transformer using DNA tetrahedral frameworks (DTFs) as programmable scaffolds. This s... |
41739936 | Ink-state preaggregation control enables scalable and automated fabrication of highly efficient and stable organic photovoltaics. | Scalability and automation are critical for advancing organic solar cells (OSCs) toward high-throughput production, yet both remain notable challenges. Here, we report a simple yet effective strategy using Tz6T as a multifunctional additive to regulate ink-state preaggregation to address both concerns. Tz6T interacts w... |
41739928 | Spatiotemporal Raman probing of molecular transport in sub-2-nm plasmonic quasi-2D nanochannels. | Capturing molecular dynamics in nanoconfined channels with high spatiotemporal resolution is a key challenge in nanoscience, crucial for advancing catalysis, energy conversion, and molecular sensing. Bottom-up ultrathin plasmonic nanogaps, such as nanoparticle-on-mirror (NPoM) structures, are ideal for ultrasensitive p... |
41739885 | African swine fever virus pEP364R acts as an important inflammatory-inducing factor to activate NLRP3 inflammasome-mediated pyroptosis by regulating DDX3X. | African swine fever virus (ASFV) infection causes a severe hemorrhagic disease in pigs, characterized by excessive inflammatory responses and tissue damage, posing substantial threats to the pig industry worldwide. Given the lack of vaccines and effective antiviral treatments, as well as the largely unknown functions o... |
41739761 | A novel mRNA-based multiepitope vaccine candidate against Cryptosporidium hominis and Cryptosporidium parvum employing reverse-vaccinology and immunoinformatics approaches. | <h4>Introduction</h4>The parasite Cryptosporidium spp. causes cryptosporidiosis, a diarrheal disease in humans and animals. This study describes the development of mRNA vaccine targeting antigens from C. hominis and C. parvum, important gut pathogens. This vaccine was designed with reverse vaccinology and immunoinforma... |
41739733 | Reporter Group-Labeled Synthetic Cellulose: Structural Characterization and Utilization in Mapping the Cellulose Chain-Cleavage Modes of Cellulases. | Iterative β-1,4-glucosylation of p-nitrophenyl (pNP)-β-cellobioside by cellodextrin phosphorylase was applied to synthesize reducing-end reporter group-labeled cellooligosaccharides (average degree of polymerization, DP: ∼5.7; DP range: 4-10) which, upon self-assembly in solution, precipitate as a cellulose allomorph I... |
41739379 | Cobalt Metal-organic Framework Alleviates DSS-Induced Ulcerative Colitis Via Barrier-protective and Immunomodulatory Effects. | Ulcerative colitis (UC) is characterized by excessive cytokine production, epithelial barrier disruption, and oxidative stress. It necessitates therapeutics with immunomodulation and mucosal integrity restoration. This study aimed to evaluate in-vivo and in-vitro therapeutic potential of Fe-MOF, Cr-MOF, and Co-MOF. RAW... |
41739347 | A pH-responsive mesoporous Zn-MOF nanocarrier for efficient cisplatin delivery and inhibition of A549 cancer cells. | Mesoporous metal-organic frameworks (MOFs) have the advantages of high specific surface area, tunable pore size, and favorable biocompatibility, making them promising candidates for drug delivery in cancer therapy. In this study, a series of mesoporous zinc-based MOF, constructed using cyclopentane dicarboxylic acid as... |
41739196 | Morphological Optimization of the Active Layer from Film Formation Kinetics in Organic Solar Cells. | A deep understanding of the structural evolution is critical for the precise morphological optimization of the active layer in organic solar cells. This perspective systematically reviews the kinetic mechanisms of film formation and emphasizes that regulating processing parameters, such as deposition temperature, proce... |
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