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41686870 | Multi-epitope vaccine design against Monkeypox virus: An immunoinformatics approach. | <h4>Background</h4>The recent outbreak of the Monkeypox virus (MPXV) across multiple regions has highlighted the need for effective vaccine. This study employed an in-silico immunoinformatics approach to design a multi-epitope vaccine against monkeypox virus.<h4>Methods</h4>The IMV heparin binding surface protein (H3L)... |
41686431 | Bioinspired Photothermic MOF-Spindle-Knot Microfibers with Ultrafast Uptake-Release for Atmospheric Freshwater Harvester. | A bioinspired photothermic MOF-spindle-knot microfiber (BPMM) is designed by using polyisopropylacrylamide, α-polyvinylidene fluoride as-grown metal-organic framework (MOF-303), and carbon black. A mechanism of water harvesting is related to the integrative effects of chemical and structural, i.e., BPMM composed of per... |
41685881 | Chiral Glass Formation by Dipeptide Salts. | A simple dipeptide WR (tryptophan-arginine) in the form of salts with organic acids tartaric acid or crotonic acid is shown to form glasses through a benign preparation route by evaporation of aqueous solution. The glasses have a remarkable range of properties including moldability, high transparency across a broad ran... |
41685805 | Toward Doubly Local Double Hybrid Functionals Using Neural-Network Local Mixing Functions. | The first optimization and evaluation of "doubly local double hybrid" (DLDH) functionals is reported. DLDHs provide a position-dependent mixing not only of exact and semi-local exchange but at the same time also of second-order perturbational (PT2) and semilocal correlation. Both admixtures are governed by local mixing... |
41685791 | Feasibility of Integrating Urinary Proteomics and Machine Learning for Diagnosing Diabetic Nephropathy. | Diabetic nephropathy (DN) represents the predominant microvascular complication associated with diabetes mellitus; however, existing diagnostic techniques are inadequate. This study evaluated candidate urinary protein biomarkers for diagnosing DN. A cohort comprising 59 patients with type 2 diabetes, 60 patients with D... |
41685771 | An RWP-RK factor links salt response and nitrogen uptake during stress-recovery in intertidal macroalgae Pyropia yezoensis (Rhodophyte). | Intertidal macroalgae such as Pyropia yezoensis routinely endure drastic and rapid fluctuations in salinity due to tidal cycles. However, the mechanisms by which these algae coordinate salt stress responses with metabolic adaptation remain unclear. In this study, transcriptomic analysis identified key genes and pathway... |
41685736 | Efficient Inhibition of TGF-β Signaling via Cytosolic Delivery of a Smad2/3-Binding Peptide Using the Cell-Penetrating PG-Surfactant <b>DKDKC</b><sub><b>12</b></sub><b>-K</b><sub><b>5</b></sub> to Block Smad2/3 Nuclear Translocation. | Targeting intracellular signaling molecules that translocate to the nucleus is a promising approach for peptide-based therapeutics. Here, we focused on Smad2/3, key mediators of TGF-β signaling that act as transcription factors upon nuclear entry. To inhibit their nuclear localization, we delivered an Smad2/3-binding S... |
41685734 | Supramolecular Self-Assembly of Organic Topological Structures from Charge-Transfer Cocrystal Alloys to Triblock Microrods. | The organic charge-transfer (CT) cocrystal alloys integrating the charming CT feature and the unique structure-property of alloys have attracted intensive attention in organic semiconductors. Finely modulating the CT interaction is critical in rationally designing the desired organic cocrystal alloys with novel topolog... |
41685720 | Deciphering the In Vivo Metabolism of Polyethylene Glycol by a Polymeromics Approach. | Polyethylene glycols (PEGs), commonly used in pharmaceutical applications, have recently been associated with potential adverse effects, highlighting the necessity for a thorough understanding of their in vivo metabolism. The inherent molecular weight polydispersity of PEGs, as polymers, poses challenges for systematic... |
41685717 | 0D-on-2D MOF-Based Membranes for Enhanced Helium Separation. | Metal-organic framework (MOF) membranes are promising for helium (He) separation, but further improvement of the selectivity is often constrained due to the lack of precise regulation of pore size based on the single-component MOFs. Herein, we designed a 0D-on-2D MOF-based composite membrane through the assembly of 0D ... |
41685698 | Enantiopurity-Dependent Peptide Coacervates and Asymmetric Organocatalysis. | Membraneless compartmentalization via liquid-liquid phase separation (LLPS) has emerged as a powerful strategy to organize biochemical reactions. Recently, peptide-based coacervates demonstrated the potential to function as microreactors by enhancing reaction kinetics through increased local concentrations and altered ... |
41685649 | Metal Organic Framework Porous Liquids for Integrated CO<sub>2</sub> Capture and Conversion. | Integrated selective capture and conversion of CO<sub>2</sub> to high-value products is a highly energy-efficient and realistic strategy toward a carbon-neutral future. Inspired by nature, we have rationally designed type-III Porous Liquids (PLs) using carbonic anhydrase (CA) mimicking ZIF-8 and Good's buffer-based ion... |
41685665 | <i>C</i><sub>3</sub>-Symmetric Photoresponsive Chiral Dopants Based on Tribenzotriquinacene. | Doping cholesteric liquid crystals (CLCs) with photoresponsive chiral molecules is an effective strategy for devising responsive soft materials, as it allows for the phototuning of the noncovalent interactions in the CLCs, and hence, their helical pitch and optical properties. Here we describe the use of tribenzotriqui... |
41685633 | Metabolic Regulation of Dimethylsulfoniopropionate Cleavage and Dimethyl Sulfide Production in Halomonas sp. D47. | Dimethylsulfoniopropionate (DMSP) is a globally significant marine organosulfur compound with diverse ecological roles, including environmental stress protection, chemotaxis, and nutrient cycling. Its microbial catabolism is crucial for the marine sulfur cycle, generating dimethyl sulfide (DMS), a volatile gas that inf... |
41685627 | Dual-Key Genetic Circuit Enables Stable and Self-Regulated Engineered Bacteria for the Treatment of Ulcerative Colitis. | Engineered bacteria offer a promising therapeutic platform but often display plasmid instability and antibiotic dependence. A synthetic dual-key genetic circuit is established in Escherichia coli Nissle 1917 (EcN) by deleting both asd and thyA genes, generating an auxotrophic chassis that requires dual-plasmid compleme... |
41685576 | Enantioselective Total Synthesis of Two Aromatized Halicyclamines. | The concise and divergent syntheses of the marine alkaloids (+)-tetradehydrohalicyclamine B and (-)-<i>epi</i>-tetradehydrohalicyclamine B are disclosed. Each synthesis requires ten steps and hinges on several key transformations including an enantioselective organocatalyzed Michael addition, a macrocyclic aza-Wittig l... |
41685517 | Regioselective Arene C-H Borylation with a MOF-Immobilized Iridium Bipyridine Catalyst. | Postsynthetic ligand exchange and metalation have been used to immobilize iridium bipyridine precatalysts in MFU-4<i>l</i> with controlled loadings. The resulting materials, <b>1-Ir-</b><i><b>x</b></i> (<i>x</i> = 0.1-0.5), exhibit high activity for catalytic C-H borylation of arenes, and <b>1-Ir-0.5</b> achieves up to... |
41685536 | Detection of highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b virus in cull dairy cows with underlying respiratory and systemic disease. | Highly pathogenic avian influenza (HPAI) A(H5N1) clade 2.3.4.4b virus was identified in 4 cull dairy cows condemned by the U.S. Department of Agriculture because of pneumonia with accompanying systemic changes. Histologic findings were bronchopneumonia in 3 cows and embolic pneumonia and nephritis in 1 cow. In addition... |
41685526 | Evolution from Analyte to Sensitive Signal Probe: Norfloxacin-Based Assembly for Machine-Learning-Assisted Discrimination of Phosphates and Monitoring of ATP Hydrolysis. | The development of sensor arrays for effective discrimination of structurally similar physiological phosphates (PPs) in mixtures presents a considerable challenge. We propose a new strategy based on concentration-regulated supramolecular assembly to construct a sensor array, integrated with machine learning, for the id... |
41685388 | Dicarbocation-Doped Polycyclic Aromatic Hydrocarbons with Efficient Deep-Red Narrowband Electroluminescence. | Narrowband heteroaromatic emitters have garnered substantial attention for their applications in wide-color-gamut displays. Nevertheless, the design strategies for narrowband heteroaromatics in red-deep-red regions are limited. Here, we report novel dicarbocation-doped polycyclic aromatic hydrocarbon (PAH) emitters wit... |
41684297 | An Unusual Ring Pattern in the Rosβ Lanthipeptide of the Two-Component Lantibiotic Roseocin. | Two-component lantibiotics comprise two post-translationally modified peptides that synergistically exert antimicrobial activity. Most known two-component lantibiotics are made up of a structurally conserved α-lanthipeptide that binds to the peptidoglycan precursor lipid II and a β-lanthipeptide that interacts with the... |
41684282 | FomA-Containing Outer Membrane Vesicles of Fusobacterium Nucleatum Facilitate Bladder Cancer Lymphatic Metastasis via IL-6-Dependent M2b Macrophage Polarization. | Outer membrane vesicles (OMVs) derived from the microbiota have emerged as key modulators of tumor progression and the immune microenvironment. However, the role of urinary microbiota and their associated OMVs proteins in the metastatic processes of bladder cancer (BCa) remains insufficiently understood. In this study,... |
41684250 | Quantum Rate Dynamics for Coherent Electron Transport at Material/Electrolyte Interfaces. | Nanoscale electronics and electrochemistry are both based on the fundamental principles of electron motion at the material/electrolyte interfaces. Despite this common ground, these fields use distinct conceptual frameworks: physicists favor coherent electron transport, while chemists rely on kinetic electron transfer. ... |
41680976 | Regulation of mitochondrial biogenesis and energy metabolism in the heart. | <h4>Abstract</h4>Mitochondrial homeostasis is regulated by processes such as biogenesis, dynamics, and mitophagy, and is essential for maintaining cardiac function while preserving structural integrity, energy supply, and redox balance. Given their high reliance on mitochondrial adenosine triphosphate generation, cardi... |
41680849 | The ADAMTS family: from extracellular matrix proteases to orchestrators of fibrosis. | Fibrosis, a pathological process defined by excessive extracellular matrix (ECM) accumulation, contributes significantly to chronic organ failure worldwide. The ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family proteins are secreted, multi-domain matrix-associated zinc metalloendopeptidases... |
41680459 | Aromatic patch in whiB-like transcription factors facilitates primary sigma factor interaction in mycobacterium tuberculosis. | WhiB-like (Wbl) family proteins are a unique family of iron-sulfur ([4Fe-4S]) cluster-bound transcription factors found exclusively in Actinobacteria and actinobacteriophages, including the notoriously persistent pathogen Mycobacterium tuberculosis (Mtb). Despite their critical roles in cell development, stress respons... |
41680212 | Food-medicine homology nanostructures: self-assembly, sustained release, and extended anti-inflammatory effects of Eucommia ulmoides nanoparticles. | Plant-derived self-assembled nanoparticles, especially from food-medicine homology sources, are gaining attention, yet their structure-function relationships remain unclear. This study identified such nanoparticles from leaf decoction of Eucommia ulmoides, a key plant in traditional Asian medicine and diet, termed EUPs... |
41680122 | Targeting coronaviral inflammation: aptamer-based strategies for emerging threats. | Coronaviruses have repeatedly emerged in recent years, causing significant and ongoing threats to global public health. The development of therapeutic agents and strategies capable of responding to future outbreaks caused by emerging coronavirus variants remain an ongoing priority. Here, we engineered a single-stranded... |
41938350 | Engineering PRRs: A new path to durable resistance. | Engineering the <i>Arabidopsis</i> cell-surface immune receptor RECEPTOR-LIKE PROTEIN 23 (RLP23) enhances plant immunity by enabling functional signaling triggered by the conserved pathogen peptide nlp20. Structural optimization enables broad-spectrum disease resistance across species without compromising growth, demon... |
41922044 | Glycoproteomics of body fluids and derived exosomes in hepatocellular carcinoma. | Hepatocellular carcinoma (HCC), a prevalent malignant tumor, is characterized by occult early symptoms, leading to most patients being diagnosed at advanced stages. This diagnostic delay significantly contributes to the high mortality and limited therapeutic efficacy observed in HCC. Therefore, the development and appl... |
41908980 | Structure-Function Coupling in Pyridyl Triazole Copolymers for Neuromorphic Synaptic Transistors. | Organic ferroelectric transistors are excellent candidates as low-cost alternatives for synaptic devices. Specifically, interfaces with donor-acceptor semiconducting polymers and copolymers of poly-(vinylidene fluoride) (PVDF) are attractive for mimicking synaptic responses. By tailoring the linking unit between the py... |
41869437 | ENDONUCLEASE V: FROM TRANSCRIPTOME REGULATOR TO CHEMICAL BIOLOGY TOOL. | Posttranscriptional modifications play a pivotal role in regulating the health and physiology of human cells and adenosine-to-inosine (A-to-I) editing is one of the most abundant of these modifications. Inosine is read as guanosine by the cellular machinery and this change impacts both the regulation and genetic code o... |
41859354 | Going beyond size: exploring the metabolic burden in <i>Pseudomonas putida</i> during heterologous protein production. | In biotechnological applications, it is often necessary to introduce genes or entire pathways into a host cell, which can create a significant metabolic burden on the host, limiting productivity. In this study, we systematically investigated the physiological stress responses of <i>Pseudomonas putida</i> during heterol... |
41841072 | Successful Long-Term Use of Isavuconazole in a Tacrolimus-Treated Japanese Kidney Transplant Recipient With Disseminated Cryptococcosis and Probable Invasive Aspergillosis. | Disseminated cryptococcosis, particularly cryptococcal meningitis, remains a severe fungal infection with high mortality in immunocompromised patients and usually requires prolonged azole therapy. In kidney transplant recipients receiving tacrolimus (TAC), careful management of drug-drug interactions via CYP3A is essen... |
41816600 | A hybrid molecular-imaging model for high-accuracy early colorectal cancer diagnosis. | <h4>Background</h4>Early and accurate detection of colorectal cancer (CRC) is crucial for improving patient survival; however, current screening methods often suffer from high false-negative rates, hindering timely diagnosis and treatment. This study aims to develop an innovative dual-path strategy that integrates mole... |
41816598 | The APOBEC3 family: a narrative review of an alternative therapeutic agent for hepatitis B virus-induced hepatocellular carcinoma. | <h4>Background and objective</h4>Hepatocellular carcinoma (HCC) ranks among the most prevalent cancers globally, representing a significant challenge to healthcare systems around the globe. Hepatitis B virus (HBV) infection is the primary causal factor for HCC, alongside various other risk elements. Timely intervention... |
41809368 | Intravenous oncolytic vaccinia expressing transgenes for enhanced safety, inhibition of shedding, imaging, and systemic cancer immunotherapy. | Oncolytic viruses are broad-spectrum cancer immunotherapies with multiple mechanisms of action that complement other therapeutics, but concerns remain regarding intravenous (i.v.) safety, overexpression of transgenes, environmental shedding, and lack of imaging in patients. Here we describe the engineering and evaluati... |
41797932 | The dual role of BRD9 in cancer: Mechanistic insights and therapeutic prospects. | Bromodomain-containing protein 9 (BRD9), an essential subunit of the switch/sucrose non-fermentable (SWI/SNF) remodeling complex, functions as a chromatin reader that recognizes acetylated lysine (Kac) residues to modulate chromatin structure and gene expression. Dysregulated BRD9 contributes to cancer cell proliferati... |
41791809 | Unlocking potent oxidase-like activity in bimetallic MnCo-MOFs: A nanozyme-based immunoassay for rapid detection of a Lumpy skin disease virus protein. | <h4>Background</h4>The escalating economic threat of Lumpy skin disease (LSD) demands rapid, point-of-care diagnostic tools that overcome the limitations of conventional methods. Current nanozyme-based assays are often limited by their reliance on unstable hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>). Our goal was to... |
41783741 | Novel Applications of Successive Self-nucleation and Annealing Thermal Fractionation for Polymer Characterization. | Successive self-nucleation and annealing (SSA) has evolved into a highly sensitive thermal fractionation protocol capable of resolving subtle lamellar and molecular heterogeneities in semicrystalline polymers. Its relevance has intensified over the past decade as SSA has been applied to sustainable, biobased, biodegrad... |
41782996 | Designing adhesive hydrogels for oral diseases treatment. | Localized drug delivery in the oral cavity is challenging owing to its wet, dynamic, and microbiologically complex nature. Adhesive hydrogels have attracted increasing attention for their ability to adhere under wet conditions, provide sustained drug release, and respond to pathological environments. This review provid... |
41782615 | Breaking through the radiation dilemma: development and clinical translation of anti-radiation drugs. | The need for effective prevention and treatment of nuclear radiation injuries is underscored by historical nuclear incidents, ongoing challenges such as nuclear wastewater management, and the expanding use of radiation in medicine and industry. Despite the approval of a limited set of drugs such as potassium iodide, Pr... |
41777531 | Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>@taurine: a magnetically recoverable green nanocatalyst for efficient synthesis of pyrano[2,3-<i>d</i>]pyrimidine derivatives. | The development of recyclable and eco-friendly catalysts for heterocyclic synthesis remains a central theme in sustainable chemistry. Here, we present a magnetically recoverable Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>@taurine catalyst, prepared by sequential silica coating and taurine functionalization of Fe<sub>3<... |
41769383 | Click chemistry-based drug delivery systems for targeted cancer therapy. | Drug delivery systems (DDSs) play a crucial role in improving the efficacy and reducing the side effects of cancer treatment. However, traditional DDSs face challenges such as poor targeting, tissue penetration, and uncontrolled drug release. Click chemistry offers a powerful tool for addressing these limitations by en... |
41769147 | Curvature Dynamics of PEGDA Asymmetric Networks via Frontal Photopolymerization: Effect of Chain Length and Optical Attenuation. | We investigate how the oligomer molecular mass, chain length, and optical attenuation affect both polymerization kinetics and the spatiotemporal response of materials patterned via frontal photopolymerization (FPP). We employ model poly-(ethylene glycol) diacrylate (PEGDA) oligomers of different chain lengths and inves... |
41769099 | Unraveling the PFOS-NSCLC axis: integrated network toxicology, machine learning, and causal inference identify EIF4EBP1 as a key molecular hub. | <h4>Background</h4>Perfluorooctanesulfonic acid (PFOS) is a persistent environmental pollutant with suspected carcinogenic potential; however, the molecular mechanisms driving PFOS-associated non-small cell lung cancer (NSCLC) remain obscure. In particular, the interplay between chemical exposure, oncogenic signaling n... |
41768991 | Lactylation in urological malignancies: emerging mechanisms and therapeutic direction. | Urological malignancies represent a group of highly aggressive tumors with a strong tendency toward therapy resistance. Their pathogenesis is closely associated with metabolic reprogramming and epigenetic regulation. In recent years, lactylation, a novel form of post-translational modification, has garnered significant... |
41768790 | Plasmalogen deficiency and the Alzheimer's disease risk of apolipoprotein E4. | The ε4 allele of the <i>APOE</i> gene, encoding the E4 isoform of apolipoprotein E, is the leading genetic risk factor for late-onset Alzheimer's disease. While many potential mechanisms have been proposed to explain this risk, no dominant or unifying process has yet emerged. Here, we explore the primary function of ap... |
41768697 | Decoding the Stability-Activity Paradox in Electrochemical Ammonia Oxidation: An Operando Perspective. | Electrochemical ammonia oxidation reaction (AOR) offers a promising avenue to produce a sustainable energy conversion system through ammonia fuel cell electrolyzers and green hydrogen generation at lower overpotential. Recently, several homogeneous and heterogeneous catalytic systems have been explored to facilitate th... |
41768653 | Enhanced Anticancer Activity of Ibuprofen and 2'-Hydroxy-2,3,5'-trimethoxychalcone-Linked Polymeric Micelles in HeLa Cells. | Cervical cancer (CVC) remains one of the most prevalent gynecological malignancies, necessitating the development of more effective therapeutic strategies to reduce tumor burden and prevent metastasis or recurrence. Conventional chemotherapy often causes severe side effects such as myelosuppression and leukopenia. This... |
41768647 | Electrochemical Sensor Based on a Composite of Babassu Starch, Carbon Black, and Cobalt Phthalocyanine for the Detection of Hydroxychloroquine. | This work presents the development of an electrochemical sensor based on a starch film extracted from the Babassu coconut mesocarp flour, carbon black (CB), and cobalt phthalocyanine. Scanning-electron microscopy coupled with energy-dispersive spectroscopy confirmed the presence of each component in composite, by confi... |
41768134 | Bioinspired cardiac-targeted metal-organic framework nanozyme for modulating inflammatory responses in heart failure with preserved ejection fraction. | <h4>Introduction</h4>Heart failure with preserved ejection fraction (HFpEF) is a common heart failure type with poor prognosis. Its mechanisms are unclear, and specific diagnostic criteria and effective treatments are lacking. Recent studies have emphasized the impact of inflammation and oxidative stress on the occurre... |
41768129 | Liposome-based drug delivery systems for skin wound healing: a promising drug delivery strategy. | Skin wound healing remains a significant challenge in clinical medicine. Liposomes (LPs), as a versatile drug delivery system, have garnered widespread attention for their potential in promoting skin wound healing. However, the limitations of conventional LPs have hindered their broader clinical applications. To enhanc... |
41768071 | Immunolocalization of matrix polysaccharides during wood decay by white rot fungus: evidence for specific interaction between hemicellulose and lignin in the wood fibre cell wall of <i>Dalbergia sissoo</i> Roxb. | Alterations in the structure and chemistry of cell wall polymers during wood decay by white-rot fungi could be one of the best experimental systems to studying the association between different cell wall polymers and the biology of plant-microbe interactions. We investigated the spatial and temporal changes in the dist... |
41767675 | PFK-158 enhances colistin efficacy against resistant <i>Edwardsiella piscicida</i> through synergistic mechanisms. | <i>Edwardsiella piscicida</i> (<i>E. piscicida</i>) is a well-known bacterial pathogen that causes severe diseases in various cultured fish species, posing a significant threat to the global aquaculture industry. The increasing incidence of multidrug resistant (MDR) <i>E. piscicida</i> has greatly limited the efficacy ... |
41767575 | The roles of post-translational modifications in the pathogenesis of RNA viruses: allies or adversaries? | Infectious diseases continue to pose major threats to global public health, owing to the persistent emergence of novel and re-emerging viruses. However, the intricate mechanisms governing virus-host interactions remain incompletely understood. Precise regulation of protein function is critical during viral infection, a... |
41767505 | CT imaging characteristics analysis of bone erosion in rheumatoid arthritis and bioinformatics study of inflammation-related gene rG4s. | <h4>Objective</h4>This work aimed to collect joint computed tomography (CT) imaging and peripheral blood transcriptome data from patients with rheumatoid arthritis (RA), and construct a deep learning model for the automatic and precise assessment of bone erosion (BE). It was to screen RA-related inflammation genes regu... |
41766895 | Beneficial effects of a high-anthocyanin diet versus a Westernized diet on colorectal cancer risk: a systematic review. | <h4>Introduction</h4>Colorectal cancer (CRC) is one of the leading causes of morbidity and mortality worldwide. Its incidence has been strongly associated with dietary patterns of the Western diet (WD), which are characterized by high intakes of saturated fats, ultra-processed foods, red and processed meats, refined gr... |
41766818 | mRNA vaccines transform personalized lung cancer treatment. | Targeted therapy and immunotherapy represent major innovations in the treatment of lung cancer. However, in patients with driver gene-positive tumors, the emergence of acquired resistance to targeted drugs is inevitable. As for immunotherapy, its efficacy in early-stage lung cancer patients remains uncertain due to str... |
41757220 | Use of gastroscopy in the management of pediatric toxic ingestions: insights from a decade of experience - a retrospective study. | <h4>Objective</h4>Pediatric poisonings account for a significant proportion of poison center consultations. Gastrointestinal decontamination (GD) is a crucial intervention in cases of acute poisoning, yet its effectiveness remains debated. This study aims to evaluate the role of esophagogastroduodenoscopy (EGD) in pedi... |
41756684 | Stable and Water-Tolerant Deep Eutectic Solvent from Biomass-Derived 5‑Hydroxymethylfurfural (HMF) and Levulinic Acid. | The development of greener extraction systems is essential to improving the sustainability of biomass valorization processes. Here we report that 5-hydroxymethylfurfural (HMF) and levulinic acid (LEV)two bioderived platform molecules often coproduced in biomass processingspontaneously form a stable liquid phase over ... |
41754976 | The Potential of Chronotherapy and Nanotherapy-Based Strategies for Glioblastoma Treatment. | Glioblastoma is the most common and aggressive brain tumour in adults, and despite ongoing efforts, effective treatment remains limited. Standard therapies often face challenges because of the tumour's specific biology, its aggressive nature, and the presence of certain physiological barriers in the brain that impede c... |
41754848 | Frags2Drugs: A Novel In Silico Fragment-Based Approach to the Discovery of Kinase Inhibitors. | <b>Background/Objectives</b>: Fragment-based approaches in the field of drug discovery and design have been widely developed and employed in both academia and industry. We present here an innovative in silico fragment-based drug design approach aimed at designing new inhibitors in the ATP-binding site of protein kinase... |
41754289 | In Silico Screening of Plant-Derived Termiticidal Compounds Targeting Cytochrome P450 in <i>Coptotermes</i> spp. (Blattodea: Rhinotermitidae) for Sustainable Termite Management. | Termites of the genus <i>Coptotermes</i> are among the most destructive structural pests worldwide, owing to their efficient lignocellulose degradation and metabolic adaptability mediated in part by cytochrome P450 enzymes. Although numerous botanical compounds have been reported to exhibit termiticidal activity, mecha... |
41752955 | Light-Controlled Membrane Fusion in Synthetic Cells. | Light-induced membrane fusion has become a pivotal technique for constructing and functionalizing synthetic cells by enabling precise control over membrane merging events. Traditional fusion approaches that rely on chemical, physical, and mechanical stimuli frequently lack both specificity and reversibility, limiting t... |
41751921 | Novel Pyridine-Based Thiazolyl-Hydrazone as a Promising Attenuator of <i>Pseudomonas aeruginosa</i> Pathogenicity by Targeting Quorum Sensing. | <i>Pseudomonas aeruginosa</i> biofilm-associated infections present higher recalcitrance to antimicrobial treatments, contributing to persistent and difficult-to-treat infections. Quorum sensing (QS) regulates various cellular processes that are important for the establishment and survival of microbial communities on t... |
41751892 | Restoring Lysosomes in Adipose Tissue Macrophages Mitigates Obesity-Induced Inflammation and Insulin Resistance. | Adipose tissue macrophages (ATMs) are key mediators of obesity-induced inflammation and insulin resistance. However, the contribution of lysosomal dysfunction to ATM inflammatory activation remains poorly defined. Here, we characterized lysosomal structural and functional alterations in ATMs during obesity and examined... |
41751715 | Information-Theoretic and Conceptual Density Functional Theory Insights on Frustration in Molecular Clusters. | Frustration is an intrinsic feature of molecular complexes, arising when individual constituents must distort from their optimal isolated geometries to achieve collective stabilization. Although energetic frustration can be defined as the average distortion energy associated with complex formation, its quantitative ori... |
41751466 | In Silico Molecular Docking and Pharmacokinetic Evaluation of Cannabinoid Derivatives as Multi-Target Inhibitors for EGFR, VEGFR-1, and VEGFR-2 Proteins. | Cancer therapy development increasingly focuses on multi-target approaches to inhibit key proteins involved in tumor growth and angiogenesis. This study explored the potential inhibitory interactions of 110 cannabinoid derivatives using molecular docking simulations against epidermal growth factor receptor (EGFR), vasc... |
41750873 | Deciphering the Flavor Chemistry, Processing and Quality Evaluation Methods of Milk Tea: A Comprehensive Review. | Milk tea is a globally popular new-style tea beverage product. In recent years, the industry has achieved rapid development in terms of scale expansion and quality iteration and upgrading. The flavor quality and product stability have become the focus of attention and research hotspots in this field. The chemical found... |
41749748 | Lipid-Polymer Nanoparticles (LiPoNs) Mediated Codelivery of AntimiR-21 and Gadolinium Chelate in Triple Negative Breast Cancer Theranostics. | RNA-based interventions are particularly promising for next-generation therapeutic strategies and hold significant potential when integrated with diagnostic modalities. Among noncoding RNAs, microRNAs (miRNAs) regulate gene expression post-transcriptionally and represent compelling targets for cancer therapy. However, ... |
41747464 | Evolutionary lineage and host origin influence virulence and mammalian adaptation of H7N9 avian influenza viruses. | The H7N9 avian influenza virus (AIV) has posed a major global public health concern since its first detection in China in 2013. Transmitted among wild birds and poultry, this virus has crossed the species barrier to infect humans, causing severe respiratory disease and high mortality. Although the widespread use of H7 ... |
41745479 | From Host-Derived Pressures to the Environmental Anti-Antimicrobial Peptides Resistome: Mechanisms, Reservoirs and Implications for Therapeutic Peptide Design. | Antimicrobial peptides (AMPs) are increasingly promoted as alternatives or complements to conventional antibiotics, yet growing evidence demonstrates that resistance to AMPs is neither rare nor incidental. Here, we define the anti-AMP resistome as a coordinated network of genetic, regulatory, and physiological mechanis... |
41744778 | Precise Mapping of the Proteasome Interaction Region (PIR) of p62/SQSTM1: Decoupling Condensate Formation from Proteasome Recruitment. | p62/SQSTM1 is a multifunctional scaffold protein central to selective autophagy and, more recently, recognized as a regulator of ubiquitin-proteasome system-mediated degradation of intracellular proteins. Within phase-separated condensates, p62 has been shown to recruit and sequester the proteasome, yet the molecular b... |
41744736 | Biosensor Technologies for Avian Influenza Detection: A New Frontier in Rapid Diagnostics for HPAI. | Avian influenza (AI), particularly highly pathogenic avian influenza (HPAI), represents a serious and growing threat to global poultry production, international trade, and human health security. Control of AI is complicated by the high evolutionary rate of influenza A viruses, which drives antigenic diversity and ongoi... |
41744634 | Active Antimicrobial Packaging Systems: Mechanisms of Microbial Control and Applications in Food Preservation. | Microbial spoilage and foodborne pathogens remain central challenges in food safety, driven by the metabolic resilience and ecological adaptability of bacteria, yeasts, and molds across diverse food matrices. Active antimicrobial packaging has emerged as a biologically informed strategy that directly targets microbial ... |
41737837 | Effects of Isothermal Treatment on A<sub>g</sub>ZIF-62: Implications on Porosity, Separations, and Grain Boundary Defect Removal. | Glasses derived from metal-organic frameworks (MOFs) combine the processing benefits of glassy materials with the accessible and selective porosity of MOFs, with potential applications in gas separation and electronics. Establishing control over MOF glasses requires an accurate understanding of how processing parameter... |
41727729 | Asymmetric synthesis of planar-chiral metacyclophanes <i>via</i> aromatic amination enabled enantioselective desymmetrization. | Metacyclophanes are a type of macrocyclic cyclophanes with the ansa chain linked to the aryl rings at the two <i>meta</i> positions, which have been widely found in natural products and bioactive small molecules. However, due to the stringent requirements for maintaining planar chirality and a crowded environment for m... |
41727723 | Integrating efficient and tailored perovskite and organic solar cells into performance-improved tandem photovoltaics. | Over the past decade, the certified power conversion efficiency of champion single-junction perovskite solar cells (PSCs) has exceeded 27%. To overcome the theoretical limitation, various perovskite-based tandem solar cells have emerged. Among them, integrating wide bandgap (WBG) perovskites with organic materials in t... |
41716737 | Pushing the limits of mechanoredox RAFT polymerization methods. | Integral aspects of what is considered green chemistry include minimizing solvent use and utilizing energy-efficient methods to synthesize target materials. For polymer synthesis in particular, accessing copolymer sequences derived from immiscible feedstocks and masses in the ultra-high molecular weight regime (>1 MDa)... |
41713139 | Targeting rheumatoid arthritis biomarkers: High-abundance protein depletion by silicomolybdic acid-functionalized metal-organic frameworks. | High-abundance proteins (HAPs) constitute more than 90% of total serum proteins, and their selective removal is crucial for improving the detection of low-abundance proteins that play key roles in disease mechanisms and potential biomarker discovery. In rheumatoid arthritis (RA), existing diagnostic potential biomarker... |
41710585 | From Ancient Spice to Advanced Science: Therapeutic, Nutraceutical and Nanotechnological Insights into the Fruits of <i>Piper Longum</i> Linn for Modern Drug Development. | <i>Piper longum</i> Linn (<i>P. longum</i>), a historically revered culinary spice and medicinal herb, has transitioned from its traditional roots in Ayurveda, Siddha, and Unani medicine to modern biomedical and technological applications. This review provides a comprehensive overview of its phytochemistry, therapeutic... |
41710577 | Tumor Targeting with Peptide-Drug Conjugates: Showcasing Key Progress and Hurdles. | Peptide-drug conjugates (PDCs) are modular, targeted therapeutics composed of a homing peptide linked to a cytotoxic or modulating drug payload via a cleavable/non-cleavable linker. PDCs utilize peptide targeting to enhance the delivery of potent drugs to tumors, providing advantages such as superior tissue penetration... |
41710207 | Nuclear quantum effects and vibrational resonances in organic hydrates: theoretical and experimental insights from DMSO monohydrate. | In the present work, we apply first-principles semiclassical dynamics to investigate a characteristic vibrational resonance in organic monohydrates, between the hydrogen-bonded OH stretching (OHb) and a three-quanta combination band composed of the water bending overtone coupled to a libration (b2lib). A reliable metho... |
41695600 | Integrated Multiomics Elucidates Molecular Mechanisms of Bisphenol A in Exacerbating Crohn's Disease. | <h4>Background</h4>Bisphenol A (BPA), a widespread environmental endocrine-disrupting chemical, has been associated with the development and progression of Crohn's disease (CD), yet its precise molecular mechanisms remain unclear. We aimed to systematically elucidate the potential molecular mechanisms by which BPA exac... |
41690595 | Molecular basis of fibrinogen recognition by the innate immune receptor LILRA2. | Human leukocyte immunoglobulin-like receptors (LILRs) are cell surface receptors that are mainly expressed in immune cells. LILRs are involved in immune cell regulation. As a member of the LILR family, LILRA2 was reported to recognize the bacterially N-terminus truncated Ig (N-truncated Ig) for the induction of innate ... |
41689943 | Cyclodextrin metal-organic framework engineered titanium surface: Targeted modulation of foam cell lipid homeostasis and inflammatory resolution. | Inflammatory responses and foam cell formation represent pivotal pathogenic drivers in the progression of atherosclerosis. β-Cyclodextrin (β-CD) exhibits anti-inflammatory activity and inhibits macrophage lipid phagocytosis, thereby effectively suppressing foam cell generation. Cyclodextrin-based metal-organic framewor... |
41688823 | Sequence and chemical specificity define the functional landscape of intrinsically disordered regions. | Intrinsically disordered regions (IDRs) pervasively engage in essential molecular functions, yet they are often poorly conserved as assessed by sequence alignment. To explore the seeming paradox of how sequence variability is compatible with persistent function, we examined the functional determinants for a poorly cons... |
41687547 | Exosome-mediated antiviral testing system and identification of Punicalagins and Anthocyanidins as promising antiviral agents against SARS-CoV-2. | Emerging viral infections like SARS-CoV-2 (SCV-2) highlight the need for effective antiviral therapies. We aimed to establish a biosafety level 2 (BSL-2) compatible screening platform using an exosome-polyethylenimine based gene delivery matrix (EPM) to evaluate plant-derived polyphenols for their antiviral potential a... |
41687505 | In situ structural studies of membrane protein megacomplexes. | Membrane protein complexes are essential for cellular functions, which rely on both constituent protein structures and their interactions within native membranes. While in vitro methods have successfully yielded high-resolution structures of individual proteins and subcomplexes, these approaches typically require deter... |
41687341 | HDL Regulates TGFβ-Receptor Lipid Raft Partitioning, Restoring Contractile Features of Cholesterol-Loaded Vascular Smooth Muscle Cells. | Many cells identified as macrophage-like in human and mouse atherosclerotic plaques are thought to be of vascular smooth muscle cell (VSMC) origin. We identified cholesterol-mediated down-regulation of TGFβ signaling in vitro in human (h)VSMCs by localization of TGFβ receptors in membrane lipid rafts, which was reverse... |
41684202 | Facile Synthesis of Alternating Azopolymers via Ugi Multicomponent Polymerization toward Photo- and pH-Responsive Polymersomes. | Alternating azopolymers are notable in smart material design for their unique self-assembly behavior, which stems from the precisely controlled hydrophilic-hydrophobic balance and stimuli-responsiveness. Herein, we report the facile synthesis of light- and pH-responsive alternating copolymers, namely P(Azo-<i>alt</i>-P... |
41684169 | Emergent Freestanding Complex Oxide Membranes for Multifunctional Applications. | Correlated complex oxides feature tightly coupled charge, spin, orbital, and lattice degrees of freedom, which give rise to rich correlated behavior. Freestanding oxide membranes render these materials into tunable quasi-2D platforms that enable multifunctional and reconfigurable devices. This Review surveys recent adv... |
41684146 | Yb<sub>2</sub>-Tb Upconversion in a Hetero-Trimetallic Molecular Lanthanide Complex. | Photon Upconversion in molecular hetero-metallic lanthanide systems is challenged by the lack of chemical diversity displayed by the lanthanide ions. Here, we report the multi-photon photophysical properties of a series of molecular hetero-trimetallic lanthanide complexes Yb<sub>2</sub>Ln (Ln = Eu<sup>3+</sup>, Gd<sup>... |
41684126 | Highly Tough, Notch-Insensitive, and Fast Self-Healing Thermoplastic Polyurethane Elastomers by Tailored Soft Segment Design. | Achieving toughness, notch insensitivity, and self-healing within a single thermoplastic polyurethane (TPU) system is challenging. Hard domains formed by hydrogen-bonded urethane linkages provide mechanical strength but limit the chain mobility needed for healing, while soft domains enable elasticity but are more vulne... |
41684099 | Toward understanding the drivers of antibody-antigen binding. | Antibody therapeutics are capable of binding to target antigens with a high degree of specificity and affinity. Gaining an understanding of how antibody-antigen interactions are governed can provide valuable insights that may assist with rational paratope design and epitope prediction. In this work, we apply the FTMap ... |
41684095 | Synergistic Enhancement of Adsorptive Desulfurization via Multi-Metal Sites and Hierarchical Pores in NH<sub>2</sub>-ZIF-8@Ni/Co-BTC Composite: Experimental and DFT Investigations. | Hollow MOFs, utilizing large cavities (>50 nm) and hierarchical pores, significantly enhance mass transfer kinetics and site accessibility, thereby outperforming conventional microporous (<2 nm) MOFs in adsorption capacity, rate, and functional integration. Meanwhile, dual-MOF heterostructures achieve comprehensive per... |
41684050 | Myosin 7a is required for maintaining the transducing stereocilia and for force transmission to the MET channel during cochlear hair cell development. | Shaker-1 mice carry a spontaneous missense mutation in Myo7a (Myo7a<sup>Sh1</sup>) that interferes with the motor function of MYO7A. Mutation in the orthologous gene in humans causes syndromic (Usher 1B) or non-syndromic forms of deafness. In hair cells, MYO7A is expressed throughout the stereocilia, where it has been ... |
41680986 | Design of Exfoliated and Ultrathin 2D Ni-MOF/F-MWCNT Nanosheets for Advanced LIB Anodes: Combined Experimental and Computational Insights. | Two-dimensional (2D) metal-organic frameworks (MOFs) have attracted attention as anode candidates for lithium-ion batteries (LIBs), thanks to their high surface area and tunable structures. Nevertheless, their tendency to restack restricts lithium-ion transport and charge transfer, compromising electrochemical performa... |
41680766 | An autonomous siRNA delivery system targeting NLRP3: implications in Parkinson's disease. | <h4>Background</h4>Parkinson's disease is the second most common neurodegenerative disease worldwide, with no disease-modifying therapy available. NLRP3 inflammasome-linked neuroinflammation is involved in the onset and progression of Parkinson's disease; therefore, inhibition of the NLRP3 inflammasome may provide a ne... |
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