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41690944 | From nicotine to SARS-CoV-2 antivirals with potent in vivo efficacy and a broad anti-coronavirus spectrum. | Anecdotal reports about smoking that might prevent SARS-CoV-2 infection inspire the search for nicotine and its pyrolysis products as inhibitors of the SARS-CoV-2 main protease (M<sup>Pro</sup>). This effort leads to the discovery of 3-vinylpyridine as an M<sup>Pro</sup> inhibitor. 3-Vinylpyridine resembles part of nir... |
41690936 | Enabling global-scale nucleic acid repositories through versatile, scalable biochemical selection from room-temperature archives. | Conventional storage and retrieval of nucleic acid specimens, particularly unstable RNA, rely on costly cold-chain infrastructure and inefficient robotic handling, inhibiting large-scale nucleic acid archives needed for global genomic biobanking. We introduce a scalable room-temperature storage system with minimal phys... |
41690928 | Do-it-yourself protein arrays as high-throughput immunoassays enabled by confined droplets on patterned plasmonic chips. | Protein chips and arrays in parallel enable high-throughput protein detection in small-volume biological fluids, however, the limitations in sensitivity, dependence on expensive/bulky external equipment, and the need for specialized technical personnel have restricted their application in clinical and laboratory settin... |
41690917 | Intrinsically stretchable all-polymer neuromorphic visual adaptive transistors based on multidimensional-phase-separation-induced micromesh. | Stretchable neuromorphic optoelectronics requiring real-time perception and dynamic adaptive processing create tempting opportunities for wearable intelligent vision equipment. Existing bionic vision devices often lack scale-modulus deformable photosensitive materials and exhibit redundant manufacturing for complex str... |
41690908 | Structures of the eIF4G-binding RNA domains among picornaviral IRES types are topologically conserved. | RNA domains within viral IRESs are crucial for initiating cap-independent translation of the genome in many positive-sense RNA viruses. However, the structures and mechanisms of these IRES domains remain unclear. Here, we present the 3 Å resolution crystal structure of the coxsackievirus B3 (CVB3) IRES domain V (dV) as... |
41690250 | Sepsis modelling: current approaches and organ-on-chip perspectives. | Sepsis is a complex life-threatening condition involving immune dysregulation, endothelial dysfunction, and multi-organ failure. To investigate molecular and systemic processes driving disease progression, in vitro, in vivo, and ex vivo experimental methods have been developed. While these systems have advanced underst... |
41689608 | Innovative combinatory approaches with dendritic cell-based vaccines: bridging preclinical insights and clinical challenges. | Dendritic cell (DC)-based vaccines have emerged as a promising and innovative approach in the immunotherapy of both solid tumors and hematologic malignancies. Owing to their unique capacity to present antigens and activate tumor-specific T cell responses, DC vaccines play a pivotal role in counteracting tumor immune ev... |
41689544 | Photoredox and CO<sub>2</sub>-Catalyzed Deep Skeletal Remodeling Via Merged C-H and C-C Bond Cleavages. | Abundant C-H and C-C bonds can undergo homolytic cleavage through radical processes, enabling the subsequent formation of new C-C bonds that profoundly reshape molecular architectures. Yet, merging these distinct elementary steps into a single catalytic blueprint capable of achieving full skeletal reorganization has re... |
41689524 | Acquiring Focus on Paramagnetic Single-Atom Sites with Fast Magic-Angle Spinning NMR. | A new approach for characterizing paramagnetic sites in materials is introduced. It combines broadband fast magic-angle spinning (MAS) NMR data with <i>ab initio</i> computed paramagnetic NMR shifts using correlated wave functions. This study presents a challenging example of this. With Fe coordinated in a model compou... |
41689521 | Nanostructure of Polyoxometalate-Ionic Liquids: Effects of Anion Geometry and Cation Chain Length. | Polyoxometalate-ionic liquids (POM-ILs) show promise for catalysis and energy storage, but how molecular structure controls nanostructure remains unclear. This study uses small-angle X-ray scattering to examine how POM geometry and cation chain length affect self-assembly in four systems combining Keggin ([SiW<sub>11</... |
41689099 | XOR-mediated tumor-selective nanomaterial therapy: achieving tumor and immune cell dual regulation through intracellular ROS generation. | <h4>Background</h4>High reactive oxygen species (ROS) concentration displays dual functions, potentially promoting both tumor cell death and driving tumor-associated macrophage (TAM) polarization towards the M1-type to elicit a series of antitumor immune responses, positioning ROS as ideal tumor therapeutic molecules. ... |
41688493 | Single-crystal 2D covalent organic frameworks for high-capacity methane storage. | 2D covalent organic frameworks (COFs) usually possess a polycrystalline nature as well as lower porosity and surface area than 3D counterparts, restraining their exploration over gas storage applications. Herein, a substituent strategy has been proposed and employed to generate three robust single-crystal 2D COFs isome... |
41688434 | Smart biomaterials for skeletal aging repair and regeneration. | Skeletal aging associated with diverse age-related disorders is increasing due to unhealthy diets, stressful lifestyles, and rapid aging. Repair and regeneration of aging skeletons are a global issue. Despite the self-healing ability of bone and the availability of various treatment strategies, degenerative bone repair... |
41994008 | Revisiting cholesterol metabolism in hepatocellular carcinoma: a hidden driver of systemic therapy response. | Hepatocellular carcinoma (HCC) ranks as the fourth leading cause of cancer-related mortality worldwide and poses a substantial challenge in the field of oncology. The majority of patients are diagnosed at advanced stages of the disease, where systemic therapies remain the primary treatment modality. These interventions... |
41835086 | Nanoemulsion based on natural components enables oral liver-targeting delivery of Schizandrol B to enhance liver regeneration after hepatectomy in hepatocellular carcinoma. | Hepatocellular carcinoma (HCC) remains a major cause of cancer-related mortality worldwide, with partial hepatectomy (PHx) serving as the primary curative treatment. Schizandrol B (SCHB) has demonstrated significant efficacy in promoting liver regeneration and restoring hepatic function following PHx. However, the clin... |
41800025 | Advances in IL-2 Family Cytokine-Based Cancer Therapies: Overcoming Challenges Through Molecular Engineering and Delivery Strategies. | Cytokines of the common γ-chain family (IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21) are pivotal in regulating immune responses and hold significant promise for cancer immunotherapy. However, their clinical efficacy has been hindered by short serum half-life, pleiotropic off-target effects, and dose-limiting systemic toxi... |
41788761 | Multi-scale computational insights into West Nile virus E-protein adsorption on graphene and phosphorene nanomaterials. | The increasing global impact of flaviviruses highlights the critical need for diagnostic platforms and antiviral therapeutic strategies. In this context, protein-nanomaterial interactions offer valuable opportunities for the rational design of devices with tailored properties. Here, we investigated the adsorption of th... |
41782641 | Antibacterial peptidomimetics <i>via</i> fragment display on small-molecule scaffolds. | In response to the growing threat of antimicrobial resistance, scaffold-based peptidomimetics were explored as potential antibacterial agents. This innovative design approach involved fragment display on small-molecule scaffolds of ultrashort peptides and peptidomimetics with alternating cationic/hydrophobic motifs. Co... |
41769696 | A real-world study of adverse event profiles associated with the four key components of antibody-drug conjugates based on the FAERS database. | <h4>Background</h4>Antibody-drug conjugates (ADCs) exhibit structurally driven and highly heterogeneous toxicities, yet most pharmacovigilance studies remain drug-centered and lack systematic component-level evaluation. This study provides a comprehensive real-world safety assessment of FDA-approved ADCs using a compon... |
41769699 | Polydatin in respiratory diseases: multi-target mechanisms and therapeutic potential. | Respiratory diseases constitute a heterogeneous group of disorders that primarily involve the lungs. Driven by worsening air pollution, tobacco use, occupational exposures, the COVID-19 pandemic, and population aging, they show persistently high incidence with rising mortality and disability, posing a major global publ... |
41769686 | Ferroptosis and cuproptosis in head and neck squamous cell carcinoma: interconnected mechanisms and therapeutic implications. | Head and Neck Squamous Cell Carcinoma (HNSCC) is a highly prevalent malignant neoplasm worldwide. Iron and copper metabolism disorder regulate ferroptosis and cuproptosis, two forms of cell death, respectively, and play key roles in the progression and treatment response of HNSCC. Recent studies have shown that these t... |
41769684 | Advances in the treatment of recurrent aphthous stomatitis: from synthetic and natural drugs to novel drug delivery systems. | <h4>Background</h4>Recurrent aphthous stomatitis (RAS), the most common inflammatory disease of the oral mucosa, has a complex etiology and diverse pathogenesis. To date, no curative treatment exists. Recurrent oral ulcers severely impair patients' quality of life, making the development of highly effective and safe th... |
41769350 | Integrated transcriptomics and molecular docking identify hub genes and statin regulators in <i>Helicobacter pylori</i>-associated gastric mucosal pathogenesis. | <h4>Background</h4><i>Helicobacter pylori</i> (<i>H. pylori</i>), a spiral Gram-negative bacterium colonizing gastric mucosa, damages epithelial cells, driving chronic gastritis, peptic ulcers, and gastric cancer. Mechanisms of its malignant transformation remain unclear.<h4>Methods</h4>We identified differentially exp... |
41769144 | Healable and Reprocessable PETG-Based Dynamic Vinylogous Urethane Networks. | The growing demand for sustainable materials calls for innovative strategies to extend the lifetime of polymers. In response to this challenge, we explored healable and reprocessable vinylogous urethane (VU) networks derived from commercially available glycol-modified polyethylene terephthalate (PETG). These materials ... |
41769061 | The effect of cryoprotectant and storage conditions on the aggregation of poly(ethylene glycol)-poly(α-benzyl carboxylate-ε-caprolactone) nanoparticles. | <h4>Introduction</h4>The preparation of nanoparticles (NPs) in aqueous media leads to thermodynamic instability and aggregation during storage. The objective of this study was to identify an optimum condition for the storage of poly(ethylene glycol)-poly(α-benzyl carboxylate-ε-caprolactone) (PEG-PBCL) NPs with minimum ... |
41768744 | Zn(II)-Responsive Peptide Hydrogels with Tunable Mechanical Properties. | Metal-coordinated peptide assemblies represent a versatile platform for functional biomaterials; here we describe Zn-(II)-driven hydrogelation of short amphiphilic peptides. To this end, we synthesized two short amphiphilic hexapeptides, Ac-LIVKHH-NH<sub>2</sub> and Fmoc-LIVKHH-NH<sub>2</sub>, using standard Fmoc/Boc s... |
41768672 | Research on Influencing Factors and an Evaluation Method for the Breakthrough Pressure of CO<sub>2</sub> Geological Storage Caprock: A Case Study of the Chang 4 + 5 Member in the Ansai Area. | Breakthrough pressure (BP) is the core index used to evaluate caprock sealing, which plays a key role in the long-term safety of CO<sub>2</sub> geological storage. This study focuses on the caprock of the Yanchang Formation in the Ansai area of the Ordos Basin. By integrating X-ray diffraction, casting thin sections, s... |
41768658 | Design and Characterization of Functionalized Polyelectrolyte-Dicephalic Surfactant Complexes as Multipurpose Colloidal Systems. | Polyelectrolyte-surfactant complexes (PESCs) have emerged as versatile soft-matter systems, offering unique opportunities for the design of multifunctional delivery platforms. Therefore, this study investigates the design, formation, and characterization of novel PESCs based on antimicrobial-functionalized poly-(acryli... |
41768065 | Synthetic promoter design in plants: integration of computational and experimental approaches. | Understanding how to engineer transcriptional regulation in plants is key to advancing both fundamental knowledge and practical applications in plant biology. Native gene promoters, while widely used, are constrained by evolutionary pressures that limit their modularity, tunability, and predictability across genetic ba... |
41767561 | The gp38 protein inhibits host adsorption of phage vB_EcoM_SD286. | <h4>Background</h4>Bacteriophages (phages), which are viruses that infect bacteria, primarily use surface receptor-binding proteins (RBPs) to recognize and infect their hosts. Elucidating the function of specific RBPs is crucial for understanding phage-host interactions and developing phage-based antimicrobials.<h4>Met... |
41767399 | Application value of FRAX in high-altitude areas in China: a systematic review and meta-analysis. | <h4>Background</h4>High-altitude environments in China are associated with altered bone metabolism and an increased risk of osteoporotic fractures. Given the limited availability of dual-energy X-ray absorptiometry (DXA) in these regions, the FRAX tool provides a practical alternative for fracture risk assessment. Howe... |
41767179 | Assessing the Impact of Mesoporous, Co-Amorphous, and Polymer-Based Systems on Cefdinir's Dissolution and Stability Via Predictive Modeling. | The poor solubility and permeability of Biopharmaceutics Classification System (BCS) Class IV drugs pose major challenges to achieving sufficient oral bioavailability and therapeutic efficacy. Improving drug dissolution is a key strategy to enhance bioavailability, which in turn can enable more effective targeting of d... |
41766885 | Correction: Promiscuous class II-binding SARS-CoV-2-nuc derived vaccine-peptide induced extensive conventional, innate and unconventional T cell responses. | [This corrects the article DOI: 10.3389/fimmu.2025.1676455.]. |
41766759 | Beyond hypertrophy: a network physiology perspective on the cardio-neuromuscular trade-off in elite soccer. | <h4>Introduction</h4>Conventional models treat cardiovascular and neuromuscular adaptations as independent, which can hide interference between endurance and power. We investigated whether cardiac remodeling is associated with peak explosive power when adaptation is considered as an integrated system.<h4>Methods</h4>Ni... |
41765625 | Development of dual-template molecularly imprinted polymers for the selective extraction of acetamiprid and thiamethoxam. | This study presents a novel analytical method based on molecularly imprinted polymers (MIPs) synthesized using an eco-friendly β-CD-DES functional monomer. These MIPs were developed for the selective extraction of acetamiprid (ACT) and thiamethoxam (TMX). The adsorption affinity analysis revealed rapid adsorption withi... |
41756593 | Quaternized chitosan-based hollow salts as a novel curing strategy for dry-cured meat: enhancing NaCl diffusion, protein hydrolysis, and sensory quality in air-dried duck. | Traditional dry-cured meats typically contain excessive amounts of NaCl. This study introduces a novel technique using quaternized chitosan-based hollow salt to cure duck for air-dried production, aiming to reduce NaCl usage while improving product quality. Compared with traditional NaCl curing, substitution with hollo... |
41756156 | Diboron- and digermanium-doped dihydrodibenzohexacenes: Ge-B exchange to access boron-doped extended acenes. | Incorporation of main-group atoms into the backbone of polycyclic aromatic hydrocarbons offers an effective strategy to modulate their electronic structures. Boron and germanium doping is particularly attractive for enhancing optoelectronic and electrochemical properties. However, regioselective incorporation of these ... |
41755155 | Graphene-Based Sensors and Biosensors Fabricated via Pulsed Laser Deposition for Chemical and Biological Threat Detection: A Comprehensive Roadmap. | Graphene-based sensors and biosensors are attractive candidates for chemical and biological threat detection due to their high surface sensitivity, rapid transduction, and low-power operation, yet real-world deployment remains constrained by cross-sensitivity, interface instability in biosensing, and limited validation... |
41754302 | Mechanism-Driven Green Extraction of Plant Polyphenols: From Molecular Interactions to Process Integration and Intelligent Optimization. | Plant polyphenols are valuable secondary metabolites with significant bioactivities; however, their efficient extraction faces multiple challenges, including the structural complexity arising from their coexistence in free and bound forms within plant matrices, as well as their sensitivity to oxidation and heat. Althou... |
41753900 | Microfluidics-Assisted Three-Dimensional Confinement of Cholesteric Liquid Crystals for Sensing Applications. | As a class of self-organized soft matter systems merging fluidic mobility with long-range molecular order, cholesteric liquid crystals (CLCs) possess immense potential for the development of high-sensitivity, visually tractable flexible sensors. Leveraging their unique helical superstructures and stimuli-responsive pho... |
41753902 | MOF-Derived Co<sub>3</sub>O<sub>4</sub> Dodecahedrons with Abundant Active Co<sup>3+</sup> for CH<sub>4</sub> Gas Sensing at Room Temperature. | Gas sensors based on metal oxide semiconductors (MOS) have attracted significant attention in monitoring of methane emission and leakage monitoring due to their high sensitivity, fast response time, simple structure and low cost. However, the high power consumption caused by long-term high-temperature operation of MOS ... |
41753173 | Association Between Salivary Sirtuin-1 Levels and Periodontitis. | <b>Background:</b> Sirtuin-1 (SIRT-1) is one enzyme that has anti-oxidative, anti-inflammation and anti-apoptosis effects, and it is involved in regulating aging and in different age-associated disorders. Salivary SIRT-1 concentrations in periodontitis patients have been scarcely studied and only in studies with small ... |
41752605 | Renaming the 'OS-D/CSP' Family (Part 1): '4-Cysteine Soluble Proteins' (4CSPs)-Molecular Nomenclature, Structure, Expression, Evolution, Tissue-Distribution, and Pleiotropy. | Chemosensory proteins (CSPs) are found in the olfactory sensory organs (antennae and maxillary palps) and/or gustatory sensory organs (labellum and legs) and have long been accepted to function through the binding of odorants. However, the same CSPs are also expressed in many tissues other than olfactory and gustatory ... |
41751950 | Synthesis and Antitumor Potency of 2<i>E</i>,21<i>E</i>-bis-(2-Pyridinylidene)-hollongdione in NCI-60 Panel and Zebrafish Model. | Michael acceptors, such as chalcones and benzylidenes, are privileged scaffolds for the development of anticancer agents. Taking this into account, we developed a selective Claisen-Schmidt condensation of the dammarane-type triterpenoid hollongdione with pyridine-2-carbaldehyde, enabling controlled synthesis of mono- a... |
41750365 | mRNA-Encoded Antibodies: An Emerging Paradigm in Antiviral Protection. | Antibodies are a cornerstone of antiviral immunity, yet conventional recombinant antibody production remains costly and time-consuming. mRNA technology, based on synthetic mRNA encapsulated in lipid nanoparticles, offers an alternative strategy by enabling direct in vivo expression of therapeutic antibodies. This revie... |
41746097 | Future Perspectives on the Application of Systems Biology and Generative Artificial Intelligence in the Design of Immunogenic Peptides for Vaccines. | Peptide-based vaccines offer a modular and readily manufacturable platform for both prophylactic and therapeutic immunization. However, their broader translation has been constrained by the limited capacity to predict protective immunity directly from sequence-level features. Recent advances in systems vaccinology and ... |
41746093 | Challenges and Prospects in the Development of a Universal SARS-CoV-2 Vaccine. | The development of a universal SARS-CoV-2 vaccine holds great promise for achieving broad and durable protection against existing and future coronavirus variants. The identification, selection, and rational redesign of conserved viral epitopes constitute the direct immunological foundation of universal SARS-CoV-2 vacci... |
41745555 | Self-Assembled Nanoparticles with Kynureninase-Fc Fusion Protein and Pheophorbide A for Photodynamic Immunometabolic Cancer Therapy. | <h4>Background/objectives</h4>Aberrant metabolism in tumors exacerbates the immunosuppressive tumor microenvironment. The immunosuppressive metabolite kynurenine inhibits the activation of effector T cells. Current antitumor drugs targeting kynurenine focus on small molecule inhibitors, which exhibit suboptimal efficac... |
41745482 | <i>Phaeodactylum tricornutum</i> as a Chassis: Insights into Its Potential, Challenges, and Perspectives. | <i>Phaeodactylum tricornutum</i> is one of the most well-characterized microalgae and serves as a pivotal model diatom in global carbon fixation and the mediation of biogeochemical cycling of essential nutrients. Over the past few decades, the availability of a complete genome assembly, coupled with the development of ... |
41745162 | Emerging 2D MXene Materials for Flexible Thermoelectric Energy Harvesting. | The pursuit of energy-efficient technologies is crucial for achieving sustainability amid rising global energy demands and climate concerns. MXenes-a class of two-dimensional (2D) transition metal carbides, nitrides, and carbonitrides-have recently attracted significant attention in thermoelectric (TE) research due to ... |
41745161 | Leveraging Machine Learning for Screening Metal-Organic Frameworks with Selective CO<sub>2</sub> Recognition for Early Thermal Runaway in Lithium-Ion Batteries. | The escalation of thermal runaway in lithium-ion batteries presents severe safety hazards that necessitate advanced monitoring protocols to ensure early warning of potential failures. Carbon dioxide (CO<sub>2</sub>) is released during preliminary decomposition well before catastrophic failure occurs, thereby providing ... |
41744785 | Membrane Dysfunction as a Central Mechanism in LRRK2-Associated Parkinson's Disease: Comparative Analysis of G2019S and I1371V Variants. | Mutations in leucine-rich repeat kinase 2 (LRRK2) are among the most common genetic causes of Parkinson's disease (PD), yet substantial heterogeneity exists among pathogenic variants. How mutations in distinct functional domains of LRRK2 differentially perturb cellular homeostasis remains incompletely understood. Here,... |
41744782 | Ancient and Emerging Nanostructures for Innovations to Fight Head and Neck Cancer. | Head and neck squamous cell carcinoma (HNSCC) remains a major global health challenge due to its aggressive behavior, late-stage diagnosis, and high incidence of therapy resistance. At the cellular level, these clinical limitations are driven by profound alterations in oncogenic signaling, stress adaptation, DNA damage... |
41744786 | mRNA and Peptide Vaccines in Melanoma-Current Landscape and Future Direction. | Immune checkpoint inhibitors have transformed the treatment landscape for advanced melanoma in the past 15 years, delivering unprecedented and durable survival benefits. This success has propelled the development of complementary immune-directed therapies, including cancer vaccines. Among these, synthetic long peptide ... |
41737464 | Quantitative oncogene-mapping within malignant tumors through Multi-parameter MRI based on RNA-triggered nanoprobes. | Genomic instability is the important foundation and feature of cancer; hence, the precise oncogene detection is crucial for early diagnosis and pathological analysis of tumors. However, the <i>in vivo</i> oncogene-imaging is confronted with great challenge, due to the extremely low copies of oncogene in cancer cells. H... |
41737463 | <i>Klebsiella pneumoniae</i> vaccines: Evolving the blueprint from traditional platforms to mucosal and nanoscale delivery. | <i>Klebsiella pneumoniae</i> (<i>KP</i>) is a critical global health threat due to carbapenem-resistant and hypervirulent strains, necessitating effective vaccines amid declining antibiotic efficacy. This review provides a timely and systematic analysis of the current <i>KP</i> vaccine landscape. We first outline the e... |
41732781 | Deciphering hydration patterns across RNA conformations: Insights into water-mediated RNA recognition. | Water molecules play a vital role in stabilizing ribonucleic acid (RNA) structures, not only as a solvent but as active participants in molecular recognition. Yet how hydration patterns encode binding specificity across RNA conformations remains poorly understood. The human immunodeficiency virus (HIV) Rev response ele... |
41732670 | NIR-II aggregation-induced emission sonosensitizer for pyroptosis induction in bladder cancer. | Sonodynamic therapy (SDT) represents a promising methodology that employs sonosensitizers in conjunction with low-intensity ultrasound for the eradication of malignant tumors, featuring precise treatment capabilities, deep tissue penetrability, and minimal side effects. Conventional sonosensitizers often face challenge... |
41732380 | Multifunctional Cu-doped Mn<sub>3</sub>O<sub>4</sub> nanozyme hydrogel microspheres for oral targeted treatment of inflammatory bowel disease. | Oral drug therapy for inflammatory bowel disease (IBD) is often hindered by inadequate targeting, low bioavailability, and reactive oxygen species (ROS) accumulation. To address these challenges, we have developed hydrogel microspheres@Cu-Mn<sub>3</sub>O<sub>4</sub> nanozymes (HMCM) by encapsulating hydrothermally synt... |
41726337 | Detection of stipe rot disease in <i>Morchella sextelata</i> based on enhanced Fourier transform infrared spectroscopy. | Timely detection of stipe rot disease is crucial for ensuring the yield and quality of <i>Morchella sextelata</i> (morel). In this study, we propose a volatile-enhanced Fourier transform infrared (FTIR) spectroscopy method for detecting stipe rot disease. The signature volatiles of disease were analyzed and identified ... |
41718410 | Preliminary Evidence of Blood DNA Methylation Changes in Pregnant Women Adhering to a Mediterranean Diet. | <h4>Background/objectives</h4>Consumption of a Mediterranean diet (MD) has been associated with reduced incidence of non-communicable diseases and reduced overall mortality, with epigenomic effects representing plausible mediators. The aim of this pilot study was to explore potential epigenetic associations between DNA... |
41718155 | Myelin Basic Protein Post-Translational Modifications Orchestrate Astrocyte Regulatory Networks. | Multiple sclerosis (MS) pathogenesis involves not only immune-mediated myelin injury but also glial responses. We examined how three charge isomers of myelin basic protein (MBP)-native (C1), phosphorylated (C4), and citrullinated (C8)-modulate rat astrocytes. Cytokines were quantified and grouped (pro/anti-inflammatory... |
41713324 | Porphyrin-based nanozymes: From material construction and mechanism exploration to biomedical applications. | Porphyrin-based nanozymes represent a groundbreaking biomimetic strategy that revolutionizes traditional nanozyme design by surmounting the long-standing challenge of poorly defined catalytic sites. By masterfully replicating the active centers of natural enzymes, these sophisticated nanomaterials not only integrate th... |
41710375 | Diagnosis and Therapeutic Challenges of Drug-Resistant Tuberculosis Infection After Kidney Transplantation: A Rare Case Report. | <h4>Background</h4>Kidney transplant recipients are at high risk for tuberculosis (TB), particularly drug-resistant forms, due to prolonged immunosuppressive therapy. The diagnosis and treatment of TB in this population pose unique challenges, including infection control, graft protection, and drug interactions.<h4>Cas... |
41710366 | Rational Design and Responsive Transdermal Cargo Delivery of Microneedles in the Treatment of Melanoma. | Melanoma is a type of tumor that originates in the skin. Traditional treatment methods are unable to achieve effective drug concentrations at the tumor site. Many new drug delivery systems and treatment strategies have been developed to enhance the therapeutic effect of melanoma. Based on transdermal drug delivery tech... |
41696049 | Computational Optimization of CRISPR-Cas13a sgRNAs Targeting the SARS-CoV-2 Spike Gene for SHERLOCK-Based Diagnostics. | <h4>Background</h4>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has triggered a global health crisis, emphasizing the urgent need for accurate and rapid diagnostic tools. Modern molecular biology technologies, including CRISPR-Cas systems, provide highly efficient strategies for viral detection. Bioinfo... |
41695890 | Active-Site Interactions in a Synergistic Porous Structured Fe Nanoparticle-Carbon Electrocatalyst for Enhanced Redox Reactions in Alkaline Zn-Air Batteries. | In practical applications, zinc-air batteries (ZABs) require high-performance, durable, and cost-effective electrocatalysts for the critical oxygen reduction reaction (ORR) and oxygen evolution reaction (OER). Here, we describe a reflux synthesis method of constructing a porous catalyst by introducing turmeric yellow i... |
41695520 | Correction to: Luminol-conjugated cyclodextrin biological nanoparticles for the treatment of severe burn-induced intestinal barrier disruption. | [This corrects the article DOI: 10.1093/burnst/tkad054.]. |
41695434 | Self-assembled monolithic β-FeOOH/copper foam catalysts for enhanced catalytic reduction of nitrogen-containing contaminants in continuous-flow systems. | Due to its relatively automated and straightforward operational process, continuous-flow catalysis has emerged as a promising technology for treating nitrogen-containing contaminants. However, achieving high activity and low flow resistance in packed-bed catalysts within continuous-flow systems remains a grand challeng... |
41695431 | Phenylboronic acid modified Ag<sub>2</sub>S NPs for bacterial targeting photothermal antibacterial therapy and promotion of wound healing. | Photothermal therapy is an antibacterial strategy based on the photothermal conversion effect, characterized by rapid action and a low tendency for resistance. However, traditional photothermal materials often lack the ability to specifically target bacteria, which limits their precise bactericidal efficacy in complex ... |
41695416 | Dual-targeting sulfamethoxazole derivatives overcome multidrug resistance in ESKAPE pathogens by inhibiting quorum sensing and efflux pumps. | The rapid emergence of pan-drug-resistant pathogens necessitates innovative antimicrobial strategies that overcome conventional resistance. This study reports the structure-guided design of sulfamethoxazole derivatives as dual inhibitors of quorum sensing (LasR) and efflux pumps (AcrB), alongside the classic dihydropte... |
41695417 | Recent advances in nanoparticle-modified zeolites: functionalization strategies and diverse applications. | Nanoparticle-modified zeolites (NPZs) are multipurpose materials that combine the special functions of nanoparticles with the structural benefits of zeolites. They present a variety of applications in energy, environmental remediation, adsorption, and catalysis. Surface area, porosity, ion-exchange capacity, stability,... |
41695420 | A green fabrication of pharmacologically relevant fused pyrimidines using recyclable caffeine-H<sub>3</sub>PO<sub>4</sub> catalyst: insight into antibacterial and cytotoxic efficacy. | An eco-friendly and high-yielding one-pot protocol has been developed for the synthesis of pyrimido[4,5-<i>d</i>]pyrimidine derivatives utilizing caffeine-H<sub>3</sub>PO<sub>4</sub> as a recyclable, metal-free acidic catalyst under ethanolic conditions. This green approach delivers the desired fused heterocycles in no... |
41695415 | Exploring the anti-virulent potential of pyridine derivatives against <i>Vibrio cholerae</i>. | <i>Vibrio cholerae</i>, the causative agent of cholera, poses a continuous threat to global public health, especially in regions with poor sanitation. Its ability to form biofilms and rapidly acquire antimicrobial resistance (AMR) complicates therapeutic interventions. In this study, the quorum-sensing (QS) response re... |
41695409 | CoP-nanorod-doped Co heterostructured electrode for efficient electrocatalytic hydrogen evolution reaction. | A high-performance CoP-nanorod doped Co metal on Ni foam (CoP/Co/NF) electrocatalytic electrode was designed <i>via</i> a two-step strategy involving electrodeposition and low-temperature phosphorization. The heterogeneous structures of metallic Co and CoP on the Ni foam are expected to provide hierarchical interfaces,... |
41693916 | Effect of Genipin Crosslinking on the Cellular Delivery of Gelatin Nanocarriers Using Curcumin as a Payload. | Gelatin-based nanoformulations have received special attention for drug delivery applications because of their regulatory acceptability. A thorough understanding of the factors controlling the interaction of gelatin nanocarriers with cellular systems is crucial for their future biomedical applications. The present stud... |
41692248 | Lipidation as a post-translational code for protein liquid-liquid phase separation. | Liquid-liquid phase separation has emerged as a central organizing mechanism that drives the formation of biomolecular condensates and enables cells to spatially and temporally coordinate metabolism, signaling, and gene expression. While the influence of post-translational modifications such as phosphorylation and ubiq... |
41692209 | Facile preparation of metal organic framework material decorated chitosan composite to efficiently rid hazardous dye methyl orange. | The design and preparation of adsorbents are crucial in the field of wastewater treatment. The composite adsorbents with chitosan (CTS) and metal organic framework (MOF) were fabricated to enhance the diffusion degree of MOF and acid stability of CTS by heating reflux method and effect of ratio of CTS, Cu<sup>2+</sup> ... |
41692172 | Advances in metal-organic framework-based drug delivery system in cuproptosis-mediated cancer therapy. | Cancer continues to pose an immense burden on global health, ranking among the foremost causes of disease-associated mortality. Conventional diagnostic platforms for tumor biomarkers, while widely adopted, remain constrained by limited sensitivity, protracted workflows, and substantial economic costs, thereby restricti... |
41692104 | Size-Transformable amphiphilic dendrimer-based drug Nanomicelles for enhanced tumor penetration in cancer chemotherapy. | Nanotechnology-based drug delivery systems (NDDSs) represent a promising paradigm for cancer therapy. Nonetheless, their clinical translation is substantially impeded by the heterogeneous and physiologically complex tumor microenvironment-particularly the limited penetration of therapeutic agents into the deeper stroma... |
41692045 | Immunosuppressive-responsive hydrogel for self-regulated drug release and tumor microenvironment reprogramming. | The tumor immunosuppressive microenvironment (TIME) critically suppresses antitumor immunity and fosters tumor growth and metastasis, leading to treatment resistance and poor prognosis. Inhibition of the upstream immunosuppressive regulator transforming growth factor-β (TGF-β) is an effective approach but systemic bloc... |
41689150 | The unmet need for the mitigation of snakebite envenoming in India: a one health perspective. | Snakebite envenoming represents a significant public health challenge, particularly in regions, where venomous snakes are endemic. The One Health approach, which recognizes the interconnectedness of human, animal, and environmental health, offers a promising framework for addressing the complex dynamics of snakebite en... |
41689141 | Mitochondrial DNA: a molecular switch driving sterile neuroinflammation. | Mitochondrial DNA (mtDNA) plays a pivotal role in the regulation of neuroinflammation, acting as a potent trigger of innate immune responses when released into the cytoplasm or extracellular space. mtDNA is structurally similar to bacterial DNA, containing unmethylated CpG motifs that are readily recognized by immune s... |
41689076 | uPAR deficiency triggers TGFβ1-mediated fibrotic remodeling in a cardiac perivascular-like microenvironment. | <h4>Background</h4>Cardiac fibrosis represents a significant health burden, with endothelial dysfunction and damaged perivascular microenvironment increasingly recognized as key contributors to fibrotic remodeling. The urokinase plasminogen activator receptor (uPAR), a critical component of the urokinase system, plays ... |
41689026 | An immunomodulatory hydrogel featuring antibacterial and ROS-scavenging functions for enhanced burn wound healing. | Infectious wounds induce a cycle of bacterial proliferation, oxidative stress accumulation, and dysregulated macrophage polarization, collectively hindering tissue repair. Conventional wound dressings typically address these pathological factors in isolation, resulting in suboptimal therapeutic outcomes. Here, we repor... |
41688792 | Membrane-associated effluxosomes coordinate multi-metal resistance in Mycobacterium tuberculosis. | Bacterial pathogens must withstand metal-induced stress during infection, yet the mechanisms by which they sense and respond to toxic metal ions remain incompletely understood. Here, we uncover a previously unrecognized mechanism in Mycobacterium tuberculosis, the causative agent of tuberculosis, which assembles dynami... |
41688736 | The redox-sensitive protein HMGB1: intracellular and extracellular roles. | HMGB1 is a non-histone nuclear protein that is primarily located in the nucleus. It can be translocated to the cytoplasm and secreted into the extracellular space upon stimulation. In the nucleus, HMGB1 functions as a DNA chaperone; in the cytoplasm, it participates in autophagy and mitochondrial homeostasis; and in th... |
41688666 | Design of a multiepitope immunotherapy for fish allergy. | Fish allergy is a significant global health concern and often leads to persistent and potentially severe hypersensitivity reactions. The molecular heterogeneity of fish allergens poses challenges for developing broadly applicable immunotherapies. In this study, an integrated immunoinformatics pipeline was used to desig... |
41688504 | Multifunctional pectin derivatives as anticancer agents in colorectal cancer via synthesis, computational insights, and modulation of NRF2/HO-1, HIF-1α, and VEGF/PDGF-D signaling pathways. | This research describes the design, synthesis, characterization, and biological assessment of new Pectin-based Hydrazide and Oxadiazole derivatives as possible anticancer agents. The chemical modification of native Pectin was accomplished using a sequence of esterification, Hydrazide formation, and cyclization with car... |
41688459 | Tracing origin and cultivation practice of Lithocarpus litseifolius via multi-data fusion and machine learning approaches. | Lithocarpus litseifolius (sweet tea) is a medicinal and edible plant rich in flavonoids and essential nutrients, with potential as a hepatoprotective beverages and natural sweetener. Although widely cultivated across several provinces in China, the quality and consistency of its raw material remain poorly regulated. To... |
41688433 | Precise synthesis of π-conjugated [3]catenanes and Solomon link for photothermal responses via a dual-tuning strategy. | Mechanically interlocked supramolecular compounds have garnered widespread attention but it remains challenging to investigate topological adjustments in such complicated structures. Here, the authors use a bidentate pyridyl ligand featuring an extended π-conjugated plane for coordination-directed self-assembly to engi... |
41687123 | Electronic Effects on the Self-Assembly of Monolayers from Surfactants Possessing Aromatic Headgroups. | Surfactant monolayers at interfaces provide a platform to investigate molecular self-assembly in pseudo-two-dimensional systems. It has been previously reported by this group that Langmuir monolayers of octadecylgallate (ODG), a phenolic surfactant, display long-range headgroup-headgroup ordering observable using grazi... |
41687121 | Myxarylin: Total <i>In Vitro</i> Biosynthesis, Expansion of Substrate Scope, and Bioengineered Thioamidated Biarylitides. | Biarylitides are a new class of ribosomally synthesized and post-translationally modified peptides (RiPPs) featuring the smallest reported precursor peptide and cytochrome P450-mediated cross-links. Here, we report the complete <i>in vitro</i> reconstitution of the myxobacterial biarylitide, myxarylin. We demonstrate t... |
41687067 | Photopatternable Thermochromism Enabled by an Anthracene Heterodimer Ligand. | Shortwave ultraviolet light retrocyclizes anthracene dimers (dianthracenes) to their corresponding monomers in the solid state, changing their solubility, fluorescence, geometry, conjugation, covalency, and more. Dianthracenes are thus an ideal building block for intrinsically photopatternable functional materials with... |
41687008 | Synergistic Mechanism of Peroxymonosulfate Activation and Photoexcitation on the Pyrolytic Bimetallic Metal-Organic Framework for Enhanced Charge Transfer. | Photocatalysis based on peroxymonosulfate (PMS) activation has shown great potential in environmental remediation, and photocatalysts containing transition-metal active sites can efficiently activate PMS. However, under-utilizing metal active sites results in limiting catalytic efficiency. To overcome this problem, thi... |
41686916 | Engineering Fluorinated Nanochannels in a Robust Tb<sub>4</sub>-Cluster MOF for Synergistic Catalysis of CO<sub>2</sub> Fixation and C-C Bond Formation. | The rational design of metal-organic frameworks (MOFs) with well-defined and cooperative catalytic microenvironments is essential for improving their performance in heterogeneous catalysis. In this work, a fluorine-functionalized rare-earth metal-organic framework, <b>NUC-162</b>, has been constructed from tetranuclear... |
41686913 | Rapidly acquired HIV-1 neutralization breadth in a rhesus V2 apex knockin mouse model after a single bolus immunization. | Current immunization strategies to elicit broadly neutralizing antibodies (bnAbs) against HIV-1 generally propose complex, multiboost regimens. In rhesus macaques, simian-human immunodeficiency virus (SHIV) infection rapidly drives the development of some bnAb classes sharing structural similarities with those in human... |
41686912 | Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV V2 apex broadly neutralizing antibody development. | Broadly neutralizing antibodies (bNAbs) are rarely elicited during HIV-1 infection. To identify obstacles to bNAb development, we longitudinally studied 122 rhesus macaques infected by 1 of 16 different simian-human immunodeficiency viruses (SHIVs). We identified the V2 apex region of the envelope (Env) as the most com... |
41686909 | De novo identification of the specificities of recurrently identified human T cell receptors. | T cell repertoires of different individuals occasionally converge on the same T cell receptor (TCR) sequence as a solution to target immunodominant epitopes. A complete mapping of these "public" TCR specificities may enable a global understanding of population-level immune histories. Here, we sought to determine the an... |
41686898 | Tubulin polymerization dynamics are influenced by magnetic isotope effects consistent with the radical pair mechanism. | Weak magnetic fields have been shown to influence biological processes; however, the underlying mechanisms remain unknown as the energies involved are far below thermal energies challenging classical explanations. Microtubule cytoskeletal fibers offer an ideal system to test weak magnetic field effects due to their sel... |
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