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41697855 | Concerted Proton-Electron Transfer Minimizes Substituent Effects on Adsorbed Phthalocyanine Electrocatalysis. | Molecularly modified electrodes (MMEs) are potent electrocatalysts, but few principles exist for their rational design. Electrocatalysis by soluble molecules depends strongly on substituents that tune the catalyst redox potential (<i>E</i><sub>1/2</sub>), but it is unclear if this parameter similarly impacts MME cataly... |
41697797 | Insights into Protein-Ligand Noncovalent Interaction Networks: A Database Survey and Quantum Chemistry Calculation Study. | Protein-ligand binding is largely determined by multiple noncovalent interactions (NCIs), which may exhibit synergistic or antagonistic effects. Here, we applied an approach combining PDB statistics with QM/MM calculations to quantify relationships among five major NCIs: halogen bonds (XB), hydrogen bonds (HB), cation-... |
41697750 | Immune correlates of HIV-1 rebound during broadly neutralizing antibody treatment in young children. | Broadly neutralizing antibodies (bnAbs) are evaluated as possible alternatives to standard antiretroviral treatment (ART) for maintaining control of HIV-1 replication and may enhance immune responses to reduce or control the viral reservoir. However, the immunological and virological effects of bnAbs in infants and chi... |
41697727 | Bioorthogonal Click Chemistry for Antibody-Free Profiling of Acetylation, Propionylation, and Butyrylation in <i>Pseudomonas aeruginosa</i> and Methicillin-Resistant <i>Staphylococcus aureus</i>. | Lysine acylation is a posttranslational modification (PTM) conserved in all domains of life and is essential for regulating diverse biological processes. Traditional methods for investigating acylation rely on anti-acyl-lysine antibodies, which are costly and time-consuming and often exhibit variable affinity. To remed... |
41697723 | Accurate Physics-Based Flexible Docking of Macrocyclic Ligands. | Macrocycles are an increasingly relevant class of therapeutics, but their size and highly constrained conformational space poses unique challenges to computational modeling. Existing modeling protocols struggle to accurately sample macrocycle bioactive conformations and predict their binding mode to receptors of intere... |
41697696 | Heavy Group 15 Element Pacman Complexes. | Calix[4]pyrrole macrocycles (Pacman ligands) were used to incorporate heavy pnictogens (As, Sb, and Bi), yielding halogeno-pnictogen complexes (<b>Pac(EX)</b><sub><b>2</b></sub>, E = As, Sb, Bi; X = Cl, I). Arsenic(III) chloro complex <b>Pac(AsCl)</b><sub><b>2</b></sub> was synthesized in solution and isolated, while a... |
41697668 | Synthesis of Tetra-Porphyrin Tubes for Catalysis and Host-Guest Chemistry. | We report a reaction between tetra-3-pyridyl and tetra-3-bromomethylphenyl porphyrins forming a tetra-porphyrin tube with alkylpyridinium linkers (24 h, 26% yield). The free-base tube (<b>FB<sub>4</sub>-tube</b>) was characterized using NMR, HR-MS, UV-vis, and single-crystal X-ray diffraction. Metalating the tolyl porp... |
41697624 | Epimerization of chlorophyll a analogs: effects of the vinyl groups in the A-ring and B-ring of the chlorin macrocycle. | Chlorophyll (Chl) a and 3,8-divinyl (DV)-Chl a are crucial pigments in efficient light-energy conversion in oxygenic photosynthesis. (C13<sup>2</sup>S)-Epimers of these pigments, Chl a' and DV-Chl a', form the primary electron donor in photosystem (PS)-I reaction center (RC) complexes. Despite the importance of Chl a' ... |
41697487 | In Silico Design and Evaluation of TcGAPDH as a Vaccine Against Chagas Disease: A Reverse Vaccinology Approach. | Purpose The current treatment for Chagas disease, caused by Trypanosoma cruzi, presents significant limitations due to its variable efficacy depending on the stage of the disease and its associated adverse effects. This issue has driven research and the development of new therapeutic and preventive strategies, with a p... |
41696945 | Cholesterol-Driven Optimization of Liposomal Systems for Ivermectin Capture: Insights from Experimental and Molecular Dynamics Studies. | This study investigates the interactions between ivermectin (IVM) and lipid membranes with varying cholesterol contents by using a combined molecular dynamics (MD) and experimental approach. DOPC bilayers containing 0, 10, 20, or 30% cholesterol were simulated, and SPC liposomes were employed for experimental validatio... |
41696792 | Evaluation of antifungal and antimycotoxigenic activity of selected natural antioxidants against Fusarium culmorum: in vitro and in planta assays. | <h4>Background</h4>Fusarium culmorum causes Fusarium head blight (FHB) in cereals, leading to significant yield losses and contamination with type B trichothecene mycotoxins such as deoxynivalenol (DON) and its acetylated derivatives 3-ADON and 15-ADON. Due to the limitations of chemical fungicides, there is increasing... |
41696786 | <i>In vitro</i> models of microbiota-gut-brain axis communication at the blood-brain barrier interface. | Microbiota-gut-brain axis dysfunction is increasingly implicated in the development of various neuropathologies. The blood-brain barrier (BBB) serves as a critical interface between the central nervous system (CNS) and the systemic milieu, modulated by the gut microbiota and associated secretome. Increasingly, the ther... |
41696764 | Synthesis, Structure, and Function of Heparan Sulfate Glycopolymers to Investigate Glycosaminoglycan-Protein Interactions. | ConspectusHeparan sulfate (HS), a highly sulfated glycosaminoglycan, varies in its disaccharide units, chain length, and sulfation patterns. HS structural diversity and its localization at cell surfaces and in the extracellular matrix enable HS interaction with a breadth of HS-binding proteins (HSBPs), HS thus being a ... |
41693699 | Palladium-catalysed synthesis of small-molecule epigenetic inhibitors as anticancer therapeutics. | Palladium-catalysed reactions have emerged as indispensable tools in medicinal chemistry, enabling the precise construction of C-C and C-N bonds across a wide spectrum of drug-like molecular frameworks. This manuscript comprehensively examines advances reported over the past five years in palladium-catalysed methodolog... |
41692853 | Rapid differentiation of D/L-homocysteine, D/L-homocystine, and S-allyl-D/L-cysteine using ion mobility-mass spectrometry. | The development of a rapid analytical method for distinguishing chiral sulfur-containing compounds is essential due to the significant differences in biological activity exhibited by different enantiomers. This work presents a straightforward and rapid method for the chiral discrimination of D/L-homocysteine (D/L-Hcy),... |
41692796 | Histidine-rich coiled-coils promote zinc-dependent self-assembly and curing of porous mussel glues. | Challenging to engineer in synthetic glues, wet adhesion is critical for many technical and biomedical applications. Mussels, however, have evolved underwater glues that adhere effectively onto slippery seashore surfaces. Past research on mussel adhesion highlights the importance of the post-translationally modified am... |
41692479 | Large cyclic AMP-dependent increases in tyrosine-phosphorylated proteins are not absolutely necessary for the induction of full-type hyperactivation and penetration into eggs in ejaculated boar spermatozoa in vitro. | Although it is well-known that sperm tyrosine-phosphorylated proteins increase in a cyclic AMP (cAMP)-dependent manner during capacitation, it remains unclear whether or not this reaction is involved directly in sperm fertilization-related events. This study aimed to examine the effects of pharmacological suppression o... |
41667401 | A transformer-based method for the cap analysis of gene expression and gene expression tag associated capping region prediction in RNA. | 5' RNA capping is one of the major post-transcriptional modifications for the mobility and stability of RNA molecules. Measuring 5' caps of RNAs can help quantify expression levels of mRNAs and lncRNAs. One of the most successful RNAseq methods that has used capping as a tool to quantify expression of transcription is ... |
41604299 | Recent advances in MXene nanozymes: synthesis, surface modifications, catalytic properties, and their emerging roles in biosensing and therapeutic applications. | MXene nanozymes have emerged as an important class of nanomaterials, bridging materials science, chemistry, and biomedicine with their exceptional catalytic properties, tunable surface chemistry, and multifunctionality. The present review highlights recent advancements and future prospects in the development and applic... |
41603738 | MXene-based fluorescent aptasensors: advances and prospects in diagnostics and environmental monitoring. | MXene-based fluorescent aptasensors leverage the synergistic integration of the intrinsic physicochemical properties of MXenes, including tunable surface chemistry, broad-spectrum optical absorption, and superior fluorescence quenching efficiency, with the molecular recognition capabilities and strong binding affinity ... |
41568872 | Development of an electrokinetic chromatography method for the rapid enantiomeric determination of 5-hydroxytryptophan. Application to the analysis of dietary supplements. | 5-Hydroxytryptophan is a chiral non-proteinogenic amino acid that plays a key role in the metabolic and neurological balance of an organism, as it is the precursor of serotonin. Dietary 5-hydroxytryptophan supplementation based on <i>Griffonia simplicifolia</i> seed extracts is widely used to enhance positive emotion r... |
41868937 | Phytochemical small molecules from <i>Stauntonia chinensis</i> DC as multi-target modulators: molecular mechanisms and therapeutic potential. | <i>Stauntonia chinensis</i> is a medicinal vine used in East Asian traditional medicine and is rich in saponins and triterpenoids with putative multi-target activities. Pre-clinical studies have reported that these compounds exert anti-inflammatory, antioxidant, neuroprotective, and anticancer effects. Evidence support... |
41868688 | Theranostic applications of CXCR4-targeted imaging ligands in lymphoma: integrating diagnosis and precision therapy. | C-X-C chemokine receptor 4 (CXCR4) is a G protein-coupled receptor implicated in immune regulation, tumor progression, and therapy resistance. In lymphoma, CXCR4 overexpression promotes malignant cell survival via microenvironmental retention and activation of pro-survival pathways, correlating with poor prognosis. Its... |
41835088 | Photothermal and cascade ROS generative multilayer as intraocular lens surface coating for effective posterior capsular opacification inhibition. | Cataract is the leading cause for blindness. While the intraocular lens (IOL) implantation is the only effective treatment in cataract surgery. Posterior capsule opacification (PCO) is the most frequent complication after cataract surgery, mainly resulting from the proliferation and migration of residual human lens epi... |
41775161 | Generation of chimeric chickens resistant to infection by avian leukemia virus subgroups A, B, D, E, and K through primordial germ cells. | Avian leukosis virus (ALVs), an oncogenic retrovirus, induces immunosuppression and various tumors in chickens, posing a severe global threat to poultry health and causing substantial economic losses. Natural resistance alleles, notably tva<sup>r2</sup> and tvb<sup>r3</sup>, confer genetic resistance to specific ALV su... |
41768654 | Controlling the Optoelectronics of Poly(3-hexylthiophene-2,5-diyl) Dendritic Star Copolymers on a Polypropylenimine Core as Donor Materials for Organic Solar Cells. | The development of novel copolymers as donor materials for organic solar cells and optimization of their properties are particularly interesting, but remain challenging. This research report presents the first study on the effect of copolymerization time on the synthesis of the copolymer poly-(propyleneimine) tetra-(<i... |
41752447 | A Double-Edged Sword: Extracellular Serine Proteases as Facilitators of Infection and Mediators of Immunity. | Serine proteases are a class of enzymes that orchestrate an immune response. These proteases can be hijacked by viruses to facilitate entry and spread, while simultaneously supporting the innate immune system in neutralizing pathogens. This review highlights the dual roles of exogenous serine proteases, emphasizing neu... |
41752007 | Lysophosphatidylethanolamine Degradation Associated with Upregulation of Pnpla6/7 in a Murine Model of Metabolic Dysfunction-Associated Steatohepatitis. | Metabolic dysfunction-associated steatohepatitis (MASH) is a form of fatty liver disease characterized by fat accumulation, hepatic inflammation, and fibrosis. Lysophosphatidylethanolamine (LPE), a partially deacylated product of phosphatidylethanolamine, plays significant roles in anti-inflammatory responses and mitoc... |
41752003 | Functional Coupling Between Voltage-Dependent Sodium Channels and Activation of the Ca<sup>2+</sup> Signaling That Mediates Endothelial Cell Migration. | Angiogenesis depends on Ca<sup>2+</sup>-mediated endothelial cell migration. The increase in intracellular Ca<sup>2+</sup> concentration ([Ca<sup>2+</sup>]<sub>i</sub>) is coordinated by caveolae and the Cx43 hemichannel opening. However, the functional coupling of voltage-dependent Na<sup>+</sup> channels (Na<sub>v</s... |
41750915 | Revealing the Impact of Starch-Pectin Interactions on the Textural Properties of Different Potato Varieties During Boiling. | This study aimed to investigate the changes in textural properties of two potato varieties (JZ-226 and XS-6) during boiling and to elucidate the interaction mechanisms within their starch-pectin composite systems, and their impacts on textural characteristics. The results showed that during the boiling process, both po... |
41745174 | Advances in Porous Silicon Materials for Sensing, Energy Storage, and Microelectronics. | Porous silicon (PSi), characterized by its high specific surface area and highly tunable morphology, presents significant potential across optoelectronics, energy storage, and biomedical applications. This review provides a systematic analysis of the synthesis methodologies, interfacial chemical engineering, and divers... |
41745171 | Morphological Design and Synthesis of Nanoparticles (Second Edition). | Nanoparticles exhibit size- and shape-dependent properties that differ from those of bulk materials, which make them suitable for a variety of applications in catalysis, biomedicine, energy storage, sensing, and environmental remediation [...]. |
41744796 | The Evolution, Oligomerization, Function, and Action Mechanism of α2-Macroglobulin. | α2-Macroglobulin (A2M), a large tetrameric glycoprotein with a molecular weight of approximately 720 kDa, is a key member of the α-macroglobulin superfamily. Its origin dates back 600-700 million years, positioning A2M as an evolutionary link within the α-macroglobulin family and complement components C3, C4, and C5. S... |
41707500 | Dual storage mechanism via hydrogen bonding and redox in 1D MOF-pillared vanadium oxide for high-performance aqueous ammonium-ion batteries. | Aqueous ammonium-ion batteries (AAIBs) have emerged as promising energy storage systems because of their inherent safety, low cost, and environmental friendliness, where developing high-performance electrode materials remains a critical challenge. Herein, a composite cathode material (Cu-BTA/VO) is designed and synthes... |
41704707 | Potential of Graphene Nanoparticles for Reducing Cadmium Toxicity and Environmental Contamination. | This narrative review synthesizes peer-reviewed studies retrieved from major scientific databases addressing the environmental and biological applications of graphene-based nanomaterials for cadmium mitigation. Cadmium (Cd) is a nonessential and highly toxic heavy metal with a prolonged biological half-life and extensi... |
41702533 | Hyaluronic-acid-modified trimetallic MOF nanoplatform integrates multiple therapeutic strategies to synergistically enhance the antitumor effect. | The unique tumor microenvironment provides unique opportunities for the chemodynamic therapy (CDT), but the efficacy of CDT is often limited by insufficient catalytic efficiency and low endogenous hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) concentrations. To address these challenges, we developed a series of glutat... |
41702512 | A multidomain peptide hydrogel-liposome composite for controlled release of a cyclic dinucleotide in oral cancer. | While immunotherapy is a promising treatment strategy for cancer, the majority of head and neck squamous cell carcinoma (HNSCC) patients treated with single-agent immunotherapy do not respond. Therefore, researchers are investigating combination treatments with immunostimulatory molecules that can maximize anti-tumor r... |
41702509 | Hybrid hydrogels for biomedical applications: Addressing challenges in drug delivery through advanced crosslinking and nanocarrier integration. | Recent years have witnessed significant advancements in the engineering potential and biomedical applications of hydrogels, driven by improvements in drug discovery, chemical engineering, and biological sciences. These developments have broadened one's knowledge in the selection of polymeric materials from the plethora... |
41702478 | Antibody-nanoparticle conjugates for precision targeting of immunosuppressive tumor microenvironment. | Cancer continues to be a significant global health and socioeconomic issue, with an unequal mortality rate in low- and middle-income nations. The progression of tumors is influenced by both intrinsic changes within cancer cells and the tumor microenvironment (TME), which is a dynamic collection of stromal cells, immune... |
41693170 | Belt-Shaped <b>[20]Collarene</b> with a Rigid Yet Adaptable Cavity for Multimodal Fullerene Complexation. | Collarenes, in which alternating benzenoid and 1,4-cyclohexadiene rings are fused to form belt-shaped hydrocarbons, show exceptional promise as molecular containers in supramolecular chemistry. However, the experimental investigation of their host-guest chemistry remains largely untapped. Herein, we report multimodal c... |
41693125 | Research Progress in Machine Learning Techniques for Metal-Organic Framework Screening. | Metal-organic frameworks (MOFs) are prime candidate materials for gas adsorption and separation owing to their exceptional porosity and structural tunability. However, the nearly infinite chemical space and exponentially growing number of candidate structures pose insurmountable challenges to traditional experimental m... |
41693099 | Remotely Tuning the Electronic Structures of Cu Site Over N-Heterocyclic Carbene-Protected Cu<sub>7</sub> Nanocluster for Steering CO<sub>2</sub> Electroreduction to Hydrocarbons. | In this study, a remote-control strategy for tuning the electronic structures of atomically precise Cu nanoclusters (Cu NCs) was developed, aiming to enhance the selectivity of the CO<sub>2</sub>RR toward high-value hydrocarbons. Two Cu<sub>7</sub> NCs protected by tridentate N-heterocyclic carbene (NHC) ligands with d... |
41693070 | Metal-Organic Frameworks for Alleviating Environmental Stress in Crops. | Global climate change and urbanization have intensified environmental stresses on agricultural systems, resulting in reduced crop yields, compromised product quality, and ecological balance. Traditional agricultural management strategies rely heavily on chemical inputs, resulting in resource waste and environmental pol... |
41693029 | 3D Metal-Organic Framework-Based Photocatalysts for Environmental Remediation: Structural Features, Mechanistic Insights, and Emerging Strategies. | The intensifying challenges of global environmental pollution and energy scarcity have underscored the urgent demand for efficient, sustainable, and environmentally friendlyremediation technologies. Among the available approaches, photocatalysis, a solar-driven process, has emerged as a particularly promising strategy ... |
41693005 | DNA as Drug Carrier: A Hydrophobic β-Cyclodextrin Channel in a Supramolecular Structure. | The adsorption of drugs and their carriers onto double-stranded DNA is potentially significant for their transport and release within cells, and β-cyclodextrins (βCDs) complexed with therapeutic compounds represent promising drug delivery systems. However, the molecular mechanisms governing the formation and behavior o... |
41692988 | Breaking the Bonds of Aging: The Underappreciated Roles of Aberrant Cysteine Crosslinks and Protective Thiol Interventions. | Aging is a complex process characterized by the accumulation of molecular damage that leads to cellular dysfunction and tissue deterioration. Among the various types of contributing molecular damage, aberrant protein crosslinks are recognized as a key contributor to age-related pathologies. Crosslinks occurring at lysi... |
41692929 | The application of metal nanomaterials in cancer diagnosis and treatment. | Cancer remains one of the most serious life-threatening diseases and a major threat to public health systems worldwide. Current diagnostic and therapeutic approaches face persistent hurdles, including toxicity resulting from the distribution of non-specific systemic anti-tumor agents, inadequate drug concentrations at ... |
41692829 | Biomimetic metal-drug coordination nanoplatform to counteract drug resistance in Pseudomonas aeruginosa via energy disruption. | The rapid emergence of antimicrobial resistance is a critical global health challenge that renders conventional antibiotics ineffective. Developing innovative strategies to resensitize drug-resistant pathogens to existing antibiotics represents a promising therapeutic approach. Here, we present a biomimetic nanoplatfor... |
41692759 | A SERS-based biosensor for optical monitoring of PARP1 trapping dynamics and high-throughput screening of modulators. | All clinically approved PARP1 inhibitors (PARPi) share NAD<sup>+</sup>-mimetic scaffolds, limiting structural diversity and hindering the discovery of next-generation agents. Their therapeutic potency depends on PARP1 trapping, a dynamic process that remains difficult to quantify, preventing the establishment of high-t... |
41692715 | Diselenide-bridged dual-action nanoscavengers drive fasting-boosted BBB penetration and ROS-responsive resveratrol delivery for synergistic ischemic stroke therapy. | The pathogenesis of ischemic stroke (IS) is critically driven by oxidative stress and the ensuing cytokine storm. While the potent reactive oxygen species (ROS) scavenger resveratrol offers neuroprotection, its targeted delivery across the blood-brain barrier (BBB) remains a substantial challenge. To address this, we d... |
41692713 | Colon-targeted microbiota-modulating nanoparticles amplify azathioprine efficacy via gut microbiota axis remodeling in inflammatory bowel disease. | <h4>Background</h4>Inflammatory bowel disease (IBD) is characterized by destruction of the intestinal barrier, dysregulation of mucosal immunity, and imbalance of the gut microbiota homeostasis. Conventional immunosuppressants such as azathioprine (AZA), commonly used in the treatment of IBD, can partially alleviate sy... |
41691635 | Self-Templated Hierarchically Porous Graphitic Aerogels for Emi Shielding. | As electronic systems become increasingly integrated into daily life, the demand for lightweight, effective, and environmentally sustainable materials for electromagnetic interference (EMI) shielding continues to grow. In this study, we investigate the EMI shielding performance of hierarchically porous graphitic aeroge... |
41691631 | Microfluidic Printing-Induced Dynamic Splitting of Conductive MOF to Expose High-Density Active Sites for Boosted CO<sub>2</sub> Electroreduction. | Electrocatalytic CO<sub>2</sub> reduction (CO<sub>2</sub>RR) is vital for carbon recycling, yet scalable production of well-defined catalysts remains challenging. Herein, we develop a rapid and scalable microfluidic printing strategy that enables dynamic splitting and directional construction of conductive metal-organi... |
41691550 | Temporally Programmed Hydrogelation of a Short Peptide Charge Transfer Complex. | Creating artificial systems that emulate the dynamic behavior of living assemblies remains a central goal in supramolecular chemistry. Here, a charge transfer-driven pH clock-regulated hydrogelation process is presented, arising from the interaction between a pyrene-lysine cysteine tripeptide (PyKC) and a phenylalanine... |
41691511 | Cation-Anion Synergy Enables Uniform and Stable SAMs for High-Efficiency Perovskite/TOPCon Tandem Solar Cells. | Hole-selective self-assembled monolayers (SAMs) have recently boosted the efficiency of perovskite/silicon tandem solar cells (TSCs), but constructing dense, uniform, and particularly stable SAMs on textured surfaces remains challenging. Here, a cation-anion synergistic strategy is employed to suppress SAMs clustering ... |
41691507 | Liposomal Nanoconfinement Enables Type I Photodynamic Conversion for Synergistic Cancer Photothermal-Immunotherapy. | Type-I photodynamic therapy (PDT) agents offer a promising approach for treating hypoxic tumors. However, previous reports mainly focused on thermodynamic modulation through molecular engineering to block the Type-II energy transfer pathway. Herein, we present a facile strategy to realize the conversion of Type II to T... |
41691494 | Bioinspired Cold-Laminated Ultrathin Hydrogels as a Broadly Adaptive Platform for Physiological Monitoring. | Soft bioelectronics provide a powerful platform for physiological monitoring, yet conventional hydrogel-based devices are constrained by inherent trade-offs between thickness, robustness, and multifunctionality, restricting their adaptability across diverse epidermal and implantable applications. Here, a novel cold-lam... |
41691487 | Stimulus-Induced Self-Reinforcement in Supramolecular Bamboo Plastics toward Mechanical Robustness and Programmable Shapeability. | The widespread use of petrochemical plastics has made environmental problems and health risks increasingly prominent. While bioplastics hold promise as alternatives, their limited heat resistance and shaping capabilities hinder widespread adoption in high-performance engineering. Here, we present an innovative supramol... |
41691485 | Lewis Pair-Engineered CuMnO<sub>x</sub> as Cold-Adapted Multinanozyme for Cooperative Hydrolytic and Oxidative Degradation of Raw Corn Stalk. | The full-component utilization of lignocellulosic biomass under mild conditions remains a formidable challenge for both biocatalytic systems and industrial processes. Herein, we report a Lewis pair engineering strategy to construct a defective Cu-doped Mn oxide nanozyme (D-CuMnO<sub>x</sub>) featuring the simultaneous ... |
41691473 | Pan-3D Genome Analysis Reveals the Roles of Structural Variation in Chicken Chromatin Architectures, Domestication and Production Traits. | As the first sequenced non-mammalian amniote, the chicken (Gallus gallus) has served as a major source of cost-effective and protein-enriched foods since domestication. However, how structural variations (SVs) affect 3D genome reorganization to influence domestication and production traits remains unclear in chickens. ... |
41691426 | Dual-Polarized Donor-Acceptor Polymer Unlocks Long-Lived Triplet Excitons for High-Efficiency H<sub>2</sub>O<sub>2</sub> Photosynthesis. | Long-lived triplet excitons in polymers are crucial for driving oxygen reduction reaction (ORR) in photocatalytic H<sub>2</sub>O<sub>2</sub> production, but their formation is typically limited by weak spin-orbit coupling (SOC) and a large singlet-triplet splitting energy (ΔE<sub>ST</sub>). Here we present a "dual-pola... |
41691422 | l-Leucine-Based Layered Coordination Polymer Supports for Immobilizing Basic Salts to Yield Solid CO<sub>2</sub> Adsorbents Resistant to Moisture and Oxidation. | We demonstrate that amino acid-based coordination polymers can serve as supports for a variety of basic salts. A layered framework, bis(l-leucinato)zinc(II), Zn(Leu)<sub>2</sub>, prepared by an aqueous, base-mediated procedure, provides crystallographically defined, carboxylato-bridged two-dimensional layered structure... |
41691417 | Engineering Chiroptical Interactions through Integrating Plasmonic Arrays with Cholesteric Nanocellulose. | Achieving scalable fabrication with precise control of chiroptical properties in chiral plasmonic materials remains challenging. We present a new family of engineered chiroptical composites comprising linearly assembled gold nanoparticle arrays integrated with cholesteric self-assembled cellulose nanocrystals (CNCs). A... |
41691416 | Stereoisomerism and Conformations of Pillar[n]arenes and Related [1<sub>n</sub>]Paracyclophanes. | Macrocyclic hosts are at the core of artificial molecular recognition and supramolecular assemblies. The key to successful hosts is easy synthesis/functionalization, 3D structures with suitable cavities, and characteristic surfaces inside/outside the macrocycles. While big successes have been limited to a few host fami... |
41691403 | Modular Supramolecular Polycations Enable Efficient Delivery of Diverse RNA Therapeutics and Vaccines. | We describe a modular, diverse, and customizable supramolecular-materials platform that can deliver nucleic acids in vitro and in vivo. The chemistries deployed enable the generation of multiple supramolecular polycations, which can associate with RNA to form polyelectrolyte complexes, but which have the unique feature... |
41691400 | Anion-Immobilized Polar Nanochannels in Metal-Organic Frameworks Enable Ion-Decoupled Transport for High-Performance Solid-State Sodium Batteries. | The development of all-solid-state polymer sodium metal batteries (ASSP-SMBs) is hindered by insufficient salt dissociation and imbalanced ion migration in polymer electrolytes. Herein, we propose an atomic level precise pore engineering strategy that integrates pore confinement with surface polarization in a metal-org... |
41691395 | Thermally Robust Hexagonally Perforated Lamellae Enabled by Asymmetric Bottlebrush Copolymers. | Hexagonally perforated lamellae (HPL) via self-assembly of block copolymers (BCPs) represent one of the most sought-after nanostructures for advanced applications, yet their practical implementation has remained elusive due to their inherent metastability in conventional linear BCPs. Here, we demonstrate a paradigm shi... |
41691383 | Material Preparation Information File (MPIF): A Community-Driven Standard for Reporting MOF Syntheses. | The rapid growth of research on metal-organic frameworks (MOFs) and related porous materials has highlighted a critical need for standardized reporting of synthetic procedures and material properties. Synthesis consistency is often compromised by incomplete protocols and inconsistent nomenclature, with even well-establ... |
41959646 | A novel biomacromolecule-predominated hybrid unit: from design, characterization to application. | Current biomaterial designs struggle with complex clinical and life science demands as single-function approaches are increasingly inadequate, necessitating the systematic integration of four core elements: biosafety, physiological compatibility, biomechanical matching, and biocatalytic function across hierarchical lev... |
41889449 | Advances in fluorescence-based point-of-care diagnostics: probes, nanostructures and integrated systems. | Fluorescence-based point-of-care (POC) technologies are rapidly evolving through advances in materials chemistry. This review provides a comprehensive overview of fluorescent molecular probes, proteins, hybrid nanostructures, metal-organic frameworks, silica platforms, carbon dots, and upconverting nanoparticles engine... |
41846073 | Oligomeric ultranano hydrogen water improves flock uniformity, antioxidant capacity and intestinal health in growth phase layer-type chickens. | This study evaluated the effects of oligomeric ultranano hydrogen water (OUHW) supplementation on growth performance, immune function, intestinal development, gut microbiota, and metabolic profiles in growing layer-type chickens. A total of 96 healthy chicks were randomly assigned to two treatments (six replicates per ... |
41783487 | Multifunctional Halloysite-Glutathione Nanocomposite for Solar CO2 Conversion and Pollutant Sensing. | This study presents a highly sustainable nanocomposite platform for dual applications in both photocatalysis and sensing. The nanomaterial is synthesized via a green process using natural, readily available components, including halloysite nanotubes (HNTs), glutathione (GSH), and xanthopterin, utilizing copper ions (Cu... |
41783488 | Cytosolic Delivery of a Bithiophene Derivative via Polymersomes Kills <i>Trypanosoma cruzi</i> Amastigotes and Modulates the Inflammatory Response. | Chagas disease, caused by the protozoan <i>Trypanosoma cruzi</i>, is an infectious illness that progresses through acute, indeterminate, and chronic phases. The acute phase often presents mild symptoms, followed by an asymptomatic indeterminate phase. In some cases, the disease advances to chronic Chagas cardiomyopathy... |
41756531 | Renal-targeted tFNA-TPP nanoagonist treats acute kidney injury by amplifying mitophagy. | Acute kidney injury (AKI) is a critical clinical syndrome closely associated with mitochondrial dysfunction. Its etiology encompasses both intrinsic renal factors and extrarenal factors, such as cardiac complications following heart surgery. AKI remains a formidable therapeutic challenge due to the absence of strategie... |
41754983 | Pulmonary Drug Delivery for Infectious Diseases: Cutting-Edge Formulations and Manufacturing Technologies. | Pulmonary drug delivery has emerged as a powerful strategy for the treatment of respiratory infectious diseases, including bacterial, fungal, and viral infections such as influenza and COVID-19, by enabling high local drug concentrations while minimizing systemic exposure. However, the clinical success of inhaled anti-... |
41754315 | Influence of the Hybrid Compound La(NO<sub>3</sub>)<sub>3</sub>@Zn-MOF on the In Vitro Growth of Sugarcane (<i>Saccharum</i> spp. L.). | In agriculture, the use of Porous Coordination Polymers (PCPs), also known as Metal-Organic Frameworks (MOFs), has emerged as a promising area of research for biological applications, particularly as long-lasting delivery systems for biostimulant chemical compounds. The objective of this study was to evaluate the effec... |
41752606 | Dopamine Enhances Healthspan and Locomotor Performance via Antioxidant Defense in Silkworms, <i>Bombyx mori</i>. | The impact of dopamine on aging is complex and context-dependent. This study systematically investigated the effects of dopamine levels on the lifespan and behavior of the silkworm moth by employing genetic mutants of the dopamine synthesis/metabolic pathway combined with pharmacological interventions. The results demo... |
41752445 | Intelligent Food Packaging Films Based on pH-Responsive Eugenol@ZIF-8/PVA-HACC with Enhanced Antimicrobial Activity. | Natural antibacterial food packaging materials endowed with environmental responsiveness are garnering substantial research interest in sustainable food preservation. This study reports the development of a pH-responsive antimicrobial composite film through encapsulation of eugenol-a natural phenolic compound-within ze... |
41751475 | Phytochemical Quorum-Sensing Inhibitors Against Bacterial Pathogens: Mechanisms of Action and Translational Challenges. | Antimicrobial resistance is a critical global health challenge, driven by the rapid emergence of multidrug-resistant bacterial pathogens and exacerbated by extensive antibiotic use, which imposes intense selective pressure and disrupts host-associated microbial communities. In this context, quorum sensing (QS), a conse... |
41751473 | Self-Assembled Hydrogels: A Novel Drug Delivery System for Osteoarthritis. | Osteoarthritis (OA) is a prevalent degenerative disease of the musculoskeletal system worldwide. Self-assembled hydrogels, as a novel drug delivery system, have demonstrated significant advantages in the treatment of OA. Through non-covalent interactions such as hydrogen bonding, hydrophobic interactions, electrostatic... |
41745284 | Stress-Activated Protein Kinase Pathways as Potential Targets for the Development of New Antifungals. | The World Health Organization WHO considers fungal infections as a significant global risk that necessitates the development of new therapies. The arsenal of antifungals is limited, and the eukaryotic organization of fungi makes it difficult to find selective antifungal targets. In the search for potential targets for ... |
41745170 | High-Throughput Surface Modification of Ordered Mesoporous Alumina Enables Structural Stabilization and Selective Chemical Control. | Porous ceramic oxides have gained significant interest as components in a wide variety of energy storage devices. Their use, however, is limited by long and high-temperature processing methods. We recently demonstrated Porogen-integrated Rapid Oxidation (PiRO) as a new method to manufacture porous aluminum oxide in sig... |
41745042 | Emerging Platforms for High-Efficiency Solar-Driven Interfacial Evaporation Desalination: MXene-Based Hydrogels/Aerogels. | The sustainable supply of freshwater resources is facing serious challenges due to the rapid industrial development, massive expansion of urbanization, and increasing environmental pollution. Solar-driven interfacial evaporation desalination (SIED) is considered one of the most promising candidates to tackle water scar... |
41745040 | Research on Polysaccharide-Protein Composite Hydrogels for Gastrointestinal Targeted Delivery: A Review. | Polysaccharide-protein composite hydrogels have demonstrated remarkable potential in targeted gastrointestinal delivery owing to their excellent biocompatibility, adjustable physicochemical characteristics, and intelligent responsiveness. This review provides a comprehensive overview of the underlying mechanisms and di... |
41745037 | A Natural Antioxidant-Rich Hydrogel Formulation with <i>Laurus nobilis</i> Hydrosol: Physicochemical and Cosmeceutical Evaluation. | <i>Laurus nobilis</i> hydrosol (HyLN), a water-soluble byproduct of essential oil extraction, containing beneficial antioxidants and antimicrobial compounds, was used as a sustainable ingredient in the development of a natural antioxidant-rich hydrogel formulation. Hydrogels were formulated using sodium hyaluronate and... |
41744740 | Hybrid Oxygen-Sensing Bio-Scaffolds for 3D Micro-Tissue Models. | Culturing cells and micro-tissue samples in 3D bio-scaffolding structures is gaining popularity; however, precise control of tissue micro-environment in such systems remains challenging. We describe a family of new hybrid bio-scaffolds with 3D O<sub>2</sub>-sensing ability, produced by simple means from readily availab... |
41737691 | Foldamer-based K<sup>+</sup> channels with ion selectivity surpassing the KcsA channel. | This study presents biomimetic supramolecular K<sup>+</sup> channels based on pore-containing foldamers with pyridine and oxadiazole backbones, aimed at high ion selectivity and transport efficiency. Modification of helical peripheral chains controlled their distribution in aqueous and lipid phases. LUV experiments dem... |
41732416 | Structural and functional characterization of sHsp from the marine cyanobacterium <i>Picosynechococcus</i> sp. NKBG15041c. | Small heat-shock proteins (sHsps) are ATP-independent chaperones whose oligomerization and client capture are regulated by a conserved C-terminal IXI/V motif. Here, we identify and characterize an sHsp from the marine cyanobacterium <i>Picosynechococcus</i> sp. NKBG15041c (NKBG-sHsp), which has an acidic C-terminal ext... |
41727528 | A medicinal chemistry perspective on SIRT3 modulators in disease treatment. | As the primary mitochondrial deacetylase, SIRT3 plays a central role in key biological processes such as cellular energy metabolism, oxidative stress response, and apoptosis regulation. It is also closely associated with the development and progression of neurodegenerative diseases, cardiovascular disorders, and variou... |
41713243 | Tuning carboxylate coordination as a molecular gearshift to optimize interfacial electron transfer for ultrafast Photochromism and highly sensitive amine detection. | The rational design of smart materials requires precise control over interfacial electron transfer, which remains a fundamental challenge. Herein, we demonstrate that a subtle shift in carboxylate coordination mode acts as a molecular gearshift, triggering optimized supramolecular π-stacking, hydrogen bonding, and lone... |
41710866 | Roadmap for light interaction with biophotonic surfaces and their diverse applications. | <h4>Significance</h4>Biophotonics has advanced through many discoveries, yet challenges remain, including label-free biomolecular specificity, quantitative imaging, and single-molecule detection. Progress is further constrained by the need for cheaper, lighter, miniaturized materials that still meet strict optical, ele... |
41707502 | Study of the interaction between graphene oxide and cholesterol using different artificial membrane models. | Graphene Oxide (GO), the hydrophilic derivative of graphene, has attracted growing attention in nanomedicine due to its ability to interact with lipid membranes and modulate their physico-chemical properties. Its amphiphilic character and high density of oxygen-containing functional groups enable strong interactions wi... |
41707424 | Dual-readout aptasensor based on CRISPR/Cas12a and nanozyme for accurate detection of KIM-1 and its application in kidney transplant prognosis. | Kidney injury molecule-1 (KIM-1) has emerged as a pivotal prognostic biomarker for renal allograft function. However, its detection remains challenging due to sensitivity and accuracy limitations. An innovative biosensing platform synergizing aptamer recognition, CRISPR trans-cleavage and nanozyme amplification for dua... |
41707266 | Performance of dual modification order using plasma-activated water and ultrasound on the multiscale and techno-functional properties of mango starch. | Exploring alternative green methods to modify unconventional starches is advancing sustainability and food security. This study examined how the order of dual modification using plasma-activated water (PAW) and ultrasound (U) affects the multi-scale structure and techno-functional properties of mango starch. The sequen... |
41691334 | Assessment of molecular interactions of L-ascorbic acid in presence of caffeine in aqueous medium using volumetric and FTIR methods. | Understanding the interactive behaviour of essential nutrients with ubiquitous stimulants is pivotal for predicting their fate and functionality in biological systems, pharmaceutical formulations and aqueous chemical environments. In this context, the study examines the molecular interactions landscape of L-ascorbic ac... |
41691251 | FBXW7 mutations reprogram glucose metabolism by activating the ETV6-GLUT1 axis. | The progression of endometrial cancer (EC) involves substantial metabolic reprogramming, frequently driven by mutations in tumor suppressors and oncogenes. In this study, we identify a previously unrecognized pathway through which FBXW7 mutations rewire glucose metabolism in EC cells. Specifically, we demonstrate that ... |
41691249 | A novel green synthesized ZnO-based antimicrobial nanocomposite: synergistic action, in vitro cytotoxicity, and molecular docking studies of ceftazidime, metformin, and chitosan against multidrug-resistant Salmonella enterica. | <h4>Background</h4>The alarming rise of multidrug-resistant (MDR) bacteria, particularly Salmonella spp., has prompted an urgent search for alternative and synergistic antimicrobial strategies. In this study, a novel, green, and multicomponent nanocomposite was synthesized by integrating zinc oxide nanoparticles (ZnO N... |
41691225 | Endogenous and exogenous stimuli-driven intelligent nanocarriers: emerging strategies for the treatment of myocardial infarction. | Myocardial infarction (MI) is one of the leading causes of death worldwide, characterized by irreversible loss of cardiomyocytes caused by ischemic injury. Despite the development of various therapeutic approaches in recent years, persistently high mortality underscores the urgent need for more advanced treatment strat... |
41691046 | Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 suppress polystyrene nanoplastic transcellular permeability and internalization by intestinal epithelial cells. | The plastic is broken into nanoscale particles (nanoplastics) that are harmful to the human body. Nanoplastics orally ingested are internalized into various cells, causing adverse effects such as oxidative stress and apoptosis; however, methods for preventing nanoplastic internalization are lacking. By elucidating this... |
41691002 | 2-Ethylhexanol inhibit Botrytis cinerea by interfering in sugar and amino acid metabolism. | The aim of this study was to evaluate the efficacy and underlying mechanism of 2-ethylhexanol (2-EH), a volatile compound, against the postharvest pathogen Botrytis cinerea on cherry tomato fruit. 2-EH demonstrated potent fungicidal activity in vitro, effectively inhibiting mycelial growth (100% inhibition at 0.08 mL L... |
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