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41680591 | Autonomous In Situ Biointerfacing Platform for Real-Time Electrophysiological Monitoring and Advanced Wound Management. | Flexible bioelectronic interfaces hold great promise for advancing modern healthcare and human-machine interactions. However, current bioelectronic interface technologies remain constrained by the intricate surface conditions of injured tissues. Even with intimate tissue-electrode adhesion, achieving simultaneous sensi... |
41680460 | Naturally occurring dinactin targets cpsA protein and kills Mycobacterium tuberculosis by disrupting the proton motive force. | Tuberculosis, especially drug-resistant tuberculosis remains a global threat, and new drugs are desperately needed to combat the spread of multidrug-resistant Mycobacterium tuberculosis. Here we describe a natural macrotetrolide dinactin with anti-tuberculosis activity against susceptive and non-replicating Mycobacteri... |
41680204 | Visible-light-triggered exclusive bistable E/Z photoswitching based on sterically frustrated dicyanostilbene derivatives. | Developing photoswitches with precise control over reaction pathways, visible-light responsiveness, and robust thermal stability remains a significant challenge in photoresponsive materials. Here we report a class of sterically frustrated dicyanostilbene-based molecular photoswitches that achieve exclusive, efficient, ... |
41680202 | Targeted elimination of Staphylococcus aureus mastitis infections with synthetic phage-based CRISPR-Cas delivery systems. | Treatment options for Staphylococcus aureus infections are increasingly limited, particularly in livestock, where S. aureus causes mastitis requiring prolonged antibiotic therapy. This study engineered Phage Inducible Chromosomal Islands (ePICIs) to deliver CRISPR-Cas9 modules targeting small RNA genes. ePICIs exhibit ... |
41680194 | Non-macrocyclic molecular design enables cavity-adaptive cocrystals with high elasticity and low-threshold lasing. | The construction of cavity-adaptive cocrystals (CACs) based on linear non-macrocyclic π-conjugated hosts remains challenging due to their inherently weak and less predictable binding capabilities compared to conventional macrocyclic hosts. Here we overcome this limitation through the rational design and synthesis of CA... |
41680158 | Colloidal synthesis of large near-bulk InAs quantum dots through seeded and seedless growth using cluster precursors. | Quantum dots are high-potential materials for a wide range of applications, particularly in the infrared spectral range, including telecommunications, security, sensing, photovoltaics, and bioimaging. The size and chemical composition of semiconductor quantum dots determine their optoelectronic properties. While II-VI ... |
41680101 | Peptide-Directed Chiral Gold Nanozymes for Asymmetric Polymerization and Chirality-Selective Cytotoxicity. | Precise control over macromolecular chirality is critical for molecular recognition and targeted biological interventions. Herein, we report a pair of chiral gold nanozymes (l-/d-AuNEs) that mimic horseradish peroxidase (HRP)-like activity to catalyze the oxidative coupling of chiral phenolic monomers in a cellular env... |
41679968 | Design Rules for Sb and Bi Porphyrin Capsules: Para-Substitution Effects and Pnictogen Bond Conformational Control. | Herein, we investigate the interplay between the heavy pnictogen bridgehead atom (E) in the tris(3-pyridyl) linkers E(3-py)<sub>3</sub> (E = Sb (<b>1</b>), Bi (<b>2</b>)), and meso-aryl substituents on the metalloporphyrin scaffolds MTPPX (M = Zn, Mg; TPPX = substituted tetraphenylporphyrin) with respect to capsule for... |
41678770 | Intracellular Fate of a Dual-Fluorescent Hydrophobic Ion Pair: Comparison of Lipid-Based Nanocarriers. | Effective intracellular trafficking and delivery of hydrophilic drugs remain challenging due to poor membrane permeability and limited encapsulation in lipid-based nanocarriers. To address this, we developed a dual-fluorescent hydrophobic ion pair (HIP) by pairing a model fluorescent hydrophilic drug, Cascade Blue hydr... |
41678610 | Structural ontogeny of protein-protein interactions. | Understanding how protein binding sites evolve interactions with other proteins could hold clues to targeting "undruggable" surfaces. We used synthetic coevolution to engineer new interactions between naïve surfaces, simulating the de novo formation of protein complexes. We isolated seven distinct structural families o... |
41678606 | Detecting supramolecular organic nanoparticles during heat wave. | New particle formation (NPF) represents a major source of tropospheric fine aerosols. A common viewpoint is that NPF hinges thermodynamically on the volatility of condensing species and is unfavorable at high temperatures. From an intensive field campaign, we observed frequent NPF events during a heat wave. Size-resolv... |
41678538 | Histidine as a Bridge: Fabricating pH-Sensitive and Target-Specific Hyaluronic Acid Nanoparticles via ZIF-8 for Drug Delivery. | The self-assembly of hyaluronic acid (HA) into stable nanoassemblies remains a significant challenge. To address this, we report a novel strategy utilizing l-histidine (His) as a molecular bridge to integrate HA with a zeolitic imidazolate framework-8 (ZIF-8). The key to this approach is the covalent conjugation of His... |
41678523 | Serine/threonine protein kinase phosphorylation of DosR alters target gene transcription mechanics and regulates Mycobacterium tuberculosis response to nitric oxide stress. | Successful host colonization by bacterial pathogens requires appropriate response and adaptation to environmental signals encountered during infection, with two-component systems (TCSs) and serine/threonine protein kinases (STPKs) being two important signal transduction mechanisms. Mycobacterium tuberculosis (Mtb) poss... |
41678495 | Remdesivir may exacerbate ischemic acute kidney injury through molecular alterations in PGC-1α and apoptosis pathways: An in vivo study. | Acute kidney injury (AKI) represents a significant complication in patients with COVID-19. Although Remdesivir (RDV) has been shown to reduce viral loads and improve clinical outcomes, concerns persist regarding its safety in individuals with pre-existing kidney impairment. This study investigated the effects of RDV on... |
41678373 | Controlled Polymerization Catalysis for the Synthesis of Degradable Amphiphilic Polycarbonates from CO<sub>2</sub>. | Synthetic water-soluble polymers are ubiquitous in solution-based applications, but their petroleum origin and nondegradable bonds create environmental concerns. Here, CO<sub>2</sub>- and glycerol-derived polycarbonates incorporating hydrophilic diglycerol motifs are prepared as a general-purpose water-soluble degradab... |
41678311 | High-speed atomic force microscopy reveals a surface-catalyzed elongation mechanism of the fungal functional amyloid hydrophobin RolA. | Hydrophobins are functional amyloids conserved in filamentous fungi. They act as a protective coat in the fibrous form, called rodlet. Rodlets further assemble to form dense films where they are bundled and densely aligned, contributing to the hydrophobicity of the mycelium surface. The mechanism of this dense film for... |
41678300 | In vitro sex-specific function-structure relationship in neonatal rat cardiac monolayers. | Even though in vivo rodent studies have been instrumental in investigating sex-specific differences in cardiac health, function, and pathology, they fall short in providing a fast and flexible platform for investigating sex differences of cardiac anisotropic monolayer in isolation. In vitro platforms offer an accessibl... |
41678088 | Advances in nanomaterials for the diagnosis and treatment of ischemic heart disease. | Ischemic heart disease (IHD) remains a leading cause of mortality worldwide. Despite timely reperfusion therapy, myocardial ischemia can still lead to ventricular remodeling, arrhythmia, and heart failure, contributing to the high prevalence of cardiovascular disease. Nanomaterials provides innovative technical methods... |
41677811 | SOPE-MsL: Synergy-Optimized Protein Language Model Embeddings with Multiscale Learning for Interpretable Protein-Small-Molecule Binding-Site Prediction. | Protein-small-molecule interactions are fundamental to cellular regulation and represent critical targets for therapeutic intervention. Accurate identification of binding residues is essential for elucidating molecular recognition mechanisms and guiding the rational drug design. Experimental approaches, however, are of... |
41677413 | Parasitic Plant-Host Interactions: Molecular Mechanisms and Agricultural Resistance Strategies. | Obligate parasitic plants, particularly members of the Orobanchaceae family, including Striga and Orobanche, greatly devastate crop production. Here, we synthesize recent advances in understanding the molecular and ecological dynamics underlying parasitic plant-host interactions, focusing on critical stages of parasiti... |
41677384 | Extracellular Vesicles in Autoimmune Diseases: From Diagnostic Biomarkers to Engineered Therapeutics. | Autoimmune diseases (ADs) are chronic disorders caused by a breakdown in immune self-tolerance, triggering aberrant immune attacks against one's own tissues. These responses cause persistent inflammation and multiorgan damage. As the global prevalence of ADs continues to increase, they impose a growing public health bu... |
41677310 | The Role of Stereoregularity in Polypropylene Melts: Insights from Coarse-Grained Simulations. | The tacticity of vinyl polymers is a crucial factor governing their physical properties, such as chain conformation and stiffness. In this work, we apply the tacticity-preserving coarse-graining methodology established by Milano and Müller-Plathe to investigate isotactic, atactic, and syndiotactic polypropylene (PP) me... |
41677118 | Reduced-Resistances Model for Enhanced Drug Permeation via a Solubilizing Receiver Medium: A Mechanistic Study with Hollow Fiber Membranes. | A solubilizing receiver medium has been documented to increase drug flux in vitro, but the mechanisms underlying this effect remain poorly understood. This study investigated these mechanisms and established a mathematical model to describe the increase in apparent permeability. Flow rate experiments were performed to ... |
41677111 | Antagonistically Functionalized Cobalt-Organic Framework Enabling Bifunctional Water Splitting and One-Pot Synthesis of Bioactive 4H-Pyrans via Synergistic Catalysis. | The rational construction of multifunctional metal-organic frameworks (MOFs) integrating redox and acid-base cooperativity offers a transformative platform for sustainable energy and green chemical synthesis. We report here a structurally undulated robust Co(II)-framework that encompasses open metal sites (OMS) and car... |
41677017 | High Resolution Imaging of Nonequilibrium Colloidal Self-Assembly via Photofixation. | The self-organization of colloidal nanoparticles into complex structures, both in equilibrium and out-of-equilibrium, is a growing area in colloidal science with potential for creating functional materials. While equilibrium assemblies form stable and periodic structures, out-of-equilibrium (or active) assemblies exhib... |
41674469 | Facilitating astaxanthin precursor accumulation in Limnospira platensis through nitrogen-doped carbon dots synthesized from bovine serum albumin. | <h4>Background</h4>Astaxanthin is widely recognized as one of the most potent natural antioxidants. However, the large-scale production of astaxanthin remains a significant challenge due to the limitations of current chemical and biosynthetic methods. To address these challenges, this study explores the use of nitrogen... |
41674408 | A Reproducible Workflow for Macrophage Membrane Isolation and Nanocore Selection Toward Bioinspired Nanoparticles Targeting Immunologically Cold Tumors. | Macrophage membrane-coated nanoparticles (M<sub>2</sub>M-NPs) offer a promising strategy for targeting immunologically "cold" tumors resistant to conventional therapies. However, workflows for membrane isolation and NP coating remain limited and often lack reproducibility. Herein, a multi-step process was established f... |
41674389 | Homochiral Indium-Oxo Clusters With Multichromatic Circularly Polarized Luminescence. | The development of chiral main-group metal-oxo clusters (MOCs) exhibiting high-performance circularly polarized luminescence (CPL) remains a significant challenge. This study presents a generalizable strategy to successfully synthesize a series of chiral indium-oxo clusters (cInOCs). These cInOCs can further self-assem... |
41674387 | Multivariate Hierarchies in Metal-Organic Frameworks. | Hierarchy is one of the fundamental laws that governs nature, where ordered structures-from plant roots to human skin-optimize mass and energy flow through precisely hierarchical pores and chemical compositions. Mimicking this intricate design in artificial materials has remained elusive, as achieving simultaneous, pre... |
41674335 | Glycine Composition and Ion Valency Tune Phase Behavior and Drug Encapsulation in Designer Peptide Condensates. | Nano- and microencapsulation that combines high loading capacity with stimulus-responsive release remains a challenge for therapeutic delivery. Designed peptide condensates formed by liquid-liquid phase separation offer a versatile and biocompatible platform to address this need. Here, we systematically link backbone f... |
41674334 | Applying dendrimer nanoprobes to the diagnosis and evaluation of kidney fibrosis. | Renal fibrosis is the central pathological process driving the progression of chronic kidney disease (CKD), representing a major global health burden. Current diagnostics, like biopsy, are invasive and lack the sensitivity for early, repeated monitoring. This creates an urgent need for noninvasive, molecularly specific... |
41674273 | Systematically Engineering for Efficient Production of 3-Methyl-1-Butanol in Escherichia coli. | 3-Methyl-1-butanol (3-MB), a promising next-generation biofuel, has garnered significant interest owing to its superior combustion characteristics and fuel compatibility. However, current 3-MB biosynthesis faces major challenges, including low production efficiency and severe toxicity-induced growth inhibition, which s... |
41673769 | Implications of virus-induced stress granules in tauopathies. | Tauopathies are characterized by aberrant tau structure and function, which is associated with neurodegenerative dementias, such as Alzheimer's disease, Pick's disease, and frontotemporal dementia, as well as the motor neuron disease amyotrophic lateral sclerosis. Consistent association of these neurodegenerative condi... |
41672966 | Lithium effects in the frontolimbic circuitry: a systematic review of neuroimaging findings in bipolar disorder. | <h4>Introduction</h4>Lithium is a cornerstone treatment for bipolar disorder, but the biological mechanisms underlying its therapeutic effects remain incompletely defined. We adopt a network-level, cross-modal perspective focused on frontolimbic circuitry and explicitly examine links between neuroimaging findings and c... |
41627161 | Strategic immobilization of α-amylase on a ZIF-8 nanoplatform for targeted bioactivity screening of <i>Gynura medica</i> extracts. | This study presents an enzyme immobilization strategy utilizing zeolitic imidazolate framework-8 (ZIF-8), a metal-organic framework (MOF) material synthesized in-house, for α-amylase immobilization, establishing a novel solid-phase extraction platform for targeted isolation of enzymatic inhibitors from <i>Gynura medica... |
41623270 | A novel molecularly imprinted quartz crystal microbalance sensor for fenamiphos determination based on boron-sulphur co-doped ultra-thin graphitic carbon nitride-incorporated Cu-MOFs. | Fenamiphos (FEN), an organophosphorus insecticide, has been frequently used in recent years to control many nematode pests. Nonetheless, its serious adverse effects have currently raised concerns about human health and the ecological environmental safety. In the present study, a novel flow injection-type portable quart... |
41601392 | Direct CO<sub>2</sub>-to-CO conversion with H<sub>2</sub>O on an In<sub>2</sub>O<sub>3</sub> photocatalyst enabled by atomically precise Pd sites. | <i>Via</i> a MOF-templated strategy, we fabricated Pd single-atom-anchored In<sub>2</sub>O<sub>3</sub> nanotubes with lattice-confined Pd-O-In coordination. This structure narrows the bandgap and boosts charge separation. <i>In situ</i> XPS and DFT calculations confirm Pd as CO<sub>2</sub> reduction sites and In as wat... |
41591789 | A sensitive electrochemical platform for paracetamol monitoring in real matrices <i>via</i> a supramolecular calix[6]arene-CuO hybrid nanocomposite. | Paracetamol is a widely used analgesic and antipyretic, and it is commonly employed to alleviate the symptoms of cold and flu. It is effective in reducing pain and fever and is readily available as an over-the-counter medication. This study aims to develop a highly sensitive electrochemical sensor for the detection of ... |
41590493 | Oxime-modified pillar[5]arene-based hybrid supramolecular polymers: construction and antibacterial performance. | An oxime-functionalized pillar[5]arene-based supramolecular polymer was constructed <i>via</i> orthogonal host-guest interactions and metal coordination. Antimicrobial activity assays demonstrated that the resulting Ag NP-doped polymer exhibits significant antibacterial efficacy against both <i>Staphylococcus aureus</i... |
41590405 | A novel electrochemical aptasensor based on β-cyclodextrinylated graphene and double-stranded DNA for ultrasensitive detection of ochratoxin A. | Given that ochratoxin A (OTA) exhibits immunotoxic, teratogenic, and carcinogenic properties, it is essential to monitor its presence in food samples. In the present work, a novel electrochemical aptasensor for OTA detection uses β-cyclodextrin-functionalized graphene (CG) to enhance electron transfer and provide abund... |
41589757 | Unveiling a novel GC-globulin host for supramolecular recognition. | GC-globulin is introduced as a powerful new supramolecular host for the first time, offering a unique architecture for cutting-edge molecular recognition. |
41560707 | Chitosan conjugated cyclodextrin nanocomposite loaded with antibiotic-adjuvant combinations remediates multi-drug resistant <i>Staphylococcus aureus</i> infection in CD-1 mice model of bovine mastitis. | Bovine mastitis (BM), resulting from intramammary infection, is one of the costliest diseases in animal agriculture. Occasional treatment failure and bacterial persistence in the mammary gland demand alternate therapeutic approaches. Nanotechnology-enabled Antibacterial Combination Therapy (NeACT), which utilizes nanom... |
41556089 | Dual pH-responsive pseudopeptide: hydrogelation and self-assembly into single- and multi-walled nanotubes. | This work reports the heterochiral tripeptide L-Phe-D-Phe-L-Phe, N-capped with vermellogen, as an ionizable pseudopeptide hydrogelator, and how the pH-responsiveness is transferred from the molecular to the nanoscale, and all the way up to the macroscale through self-assembly. In particular, the protonation of the verm... |
41971577 | Integrated network pharmacology, transcriptomics and experimental validation to explore mechanisms of Wenyang Jiedu Granule on IAV-induced pneumonia. | <h4>Objective</h4>Wenyang Jiedu Granule (WYJD) is an effective traditional Chinese medicine (TCM) preparation that has been generally applied for treating respiratory infectious diseases. Clinical observations involving thousands of cases have demonstrated that WYJD could alleviate disease progression and improve sympt... |
41962342 | Employment of mixed aptamers and gold nanobipyramids toward a paper-based aptasensor for simultaneously visual screening and accurate detection of eight sulfonamides. | A variety of sulfonamides (SAs) are extensively utilized in animal husbandry and aquaculture, necessitating the development of high-throughput methods for the rapid screening and accurate determination of multiple, ideally all commonly-applied SAs, in animal-derived foodstuffs. We herein developed a paper-based colorim... |
41868306 | Copper-ion releasing LDH nanosheets-hydrogel synergistically enhance subchondral bone repair. | Bone defects represent a significant clinical challenge, frequently resulting in nonunion and impaired function. Although autologous bone grafts are considered the gold standard owing to their excellent biocompatibility, their application is constrained by limited donor availability, thereby driving the need for altern... |
41835452 | Illuminating microtubule functions with small molecules: past, present and future of fluorescent tubulin-binding probes. | Developing tools for the real-time visualization of tubulin, microtubules, and their dynamics is essential for studying key cellular processes such as cell division, migration, and differentiation. In this context, fluorescent small-molecule probes that bind to distinct and specific sites on microtubules have significa... |
41822015 | Delivery systems in the diagnosis and treatment of chronic atrophic gastritis: A Three-Level health strategy guided by 3PM. | <h4>Introduction</h4>Chronic atrophic gastritis with accelerated progression represents a major risk factor for gastric cancer development, primarily driven by pathological processes including microbial imbalance, oxidative stress, chronic inflammation, immune dysregulation, mucin dynamics, and glycobiological disorder... |
41810078 | Phase-Change Assembling Nanostructures Synergistically Potentiate Tumor Radiosensitivity by Reducing the Stemness of Cancer Stem-Like Cells. | Cancer stem-like cells (CSCs) within deep tumors are a fundamental contributor to radiotherapy (RT) resistance due to their pronounced stemness resulting in unique unlimited self-renewal and differentiation capabilities. Alleviating hypoxic microenvironment of deep tumors to attenuate the stemness of CSCs remains a sig... |
41810065 | Unlocking the Potential of Carbon Nitride (C <i><sub>x</sub></i> N <i><sub>y</sub></i> ) Electrocatalysts in Hydrogen Evolution, Oxygen Evolution and Overall Water Splitting. | Electrocatalytic water splitting with carbon nitride (C <i><sub>x</sub></i> N <i><sub>y</sub></i> ) materials has gained significant interest, driven by extensive research validating their synthesis, structure, and applications. Among various C <i><sub>x</sub></i> N <i><sub>y</sub></i> stoichiometric ratios, graphitic ... |
41809797 | Systematic analysis of <i>UBE2D3</i> and its association with prognosis, tumor microenvironment, and drug sensitivity in renal clear cell carcinoma. | <h4>Background</h4>Dysregulated copper metabolism contributes to kidney renal clear cell carcinoma (KIRC) progression. This study systematically investigated the prognostic and therapeutic implications of copper metabolism-related gene <i>UBE2D3</i> in KIRC.<h4>Methods</h4>Utilizing The Cancer Genome Atlas (TCGA)-KIRC ... |
41799213 | Panoramic description of ROS-based nanotechnology for osteomyelitis therapy: Challenges, opportunities, and prospects. | Osteomyelitis, an inflammatory disease of bone and bone marrow caused by infectious microorganisms, has long been a major clinical challenge due to the lack of consistently effective treatment strategies. Conventional therapeutic approaches, such as antibiotic therapy and surgical debridement, are frequently associated... |
41799206 | Nanobiomaterial-enabled boron delivery systems and innovative strategies for revolutionizing BNCT. | Boron neutron capture therapy (BNCT) is a novel and emerging form of radiotherapy that combines the advantages of "heavy ion radiotherapy" and "biological targeting". The therapeutic potential of BNCT is ultimately constrained by precise and efficient delivery of boron drugs. In this review, we systematically trace fro... |
41799194 | Open Porous Microenvironment-regulatory Microspheres Loaded with Curcumin@BSA NPs/BMSCs for Diabetic Wound Treatment. | <h4>Background</h4>The process of healing wounds in diabetic patients is intricate and is notably obstructed by a disordered wound microenvironment, characterized by chronic inflammation and elevated blood glucose. The combination of stem cell therapy and drug treatment is seen as a promising application in future. How... |
41797891 | Recent advances in aptamer-integrated covalent organic frameworks for electrochemiluminescence detection of emerging pollutants. | With the rapid advancement of industrialization and urbanization, emerging pollutants (EPs) have become a significant environmental and public health concern. Characterized by persistence, bioaccumulation, and potential toxicity, their detection is crucial. Electrochemiluminescence (ECL) technology offers a promising a... |
41782642 | Emerging strategies for Alzheimer's disease: leveraging flavonoid derivatives for early diagnosis and neuroprotection. | Alzheimer's disease (AD) is a prevalent chronic and progressive neurodegenerative disorder predominantly affecting the elderly population. The etiology of AD is multifaceted, and despite extensive research, effective therapeutic options remain limited. Flavonoids, a diverse class of naturally occurring small molecules,... |
41771214 | Green supramolecular solvent-based microextraction approach using naturally-occurring components for chromatographic determination of fungicides in vegetables. | In this study, a green supramolecular solvent-based microextraction approach using naturally-occurring components (decyl glucoside and linalool) for preconcentration of agricultural benzimidazole fungicides (thiabendazole and carbendazim) from vegetables was developed. Supramolecular solvent formation in aqueous soluti... |
41768763 | Enzyme-Activated Self-Assembling Peptides Mimicking Adiponectin Multimers for Nonalcoholic Fatty Liver Disease Therapy. | Adiponectin is a multifunctional adipokine that regulates metabolic homeostasis, particularly lipid metabolism, through activation of adiponectin receptors (AdipoRs). Its high molecular weight (HMW) form exhibits the greatest biological activity, yet therapeutic peptides derived from adiponectin typically exist as mono... |
41768757 | AuNPs@Al-TDC Metal-Organic Framework: A Hybrid Nanostructure for 3D-Printed Electrochemical Sensors Targeting Diuron. | The integration of sustainability principles, green chemistry, and circular economy concepts enables the recycling of polymers such as acrylonitrile-butadiene-styrene (ABS) into innovative and functional devices. In this context, advances in composite materials and conductive filaments are essential for the development... |
41768741 | Peptide-Carbon Nanotube Hybrids under Confinement: Structure and Stability from Atomistic Simulations. | The interaction between peptides and carbon nanotubes (CNTs) represents a promising route for developing biofunctional nanomaterials that couple structural flexibility to superior electronic performance. In this work, we investigate the structural and energetic behavior of A<sub>6</sub>D peptides confined inside a sing... |
41768684 | Tumor Microenvironment-Responsive Nanoplatform of Cu-Doped ZIF‑8 Dual-Loaded with ICG and DOX for Photothermal-Enhanced Chemodynamic Therapy/Chemotherapy. | Targeting tumor-specific characteristics of acidic microenvironment, elevated H<sub>2</sub>O<sub>2</sub> levels, and thermosensitivity, this study proposed and developed a copper-doped ZIF-8 nanoplatform coloaded with indocyanine green (ICG) and doxorubicin hydrochloride (DOX), designated as Cu-ZIF-8@ICG&DOX (CZID), to... |
41768660 | Exploration of Novel Chemical Spaces to Discover JAK1 Inhibitors: An Ensemble Docking-Guided Deep Learning Approach. | Janus kinase 1 (JAK1) is a key regulator of cytokine signaling and a validated therapeutic target in autoimmune, inflammatory, and oncological disorders. However, existing JAK inhibitors such as Tofacitinib and Ruxolitinib are limited by their narrow pyrrolo-[2,3-<i>d</i>]-pyrimidine scaffold, leading to poor isoform s... |
41768678 | Spontaneous Emulsification as a Low-Energy Strategy for Designing and Optimizing Resveratrol-Loaded Nanostructured Lipid Carriers. | Nanostructured lipid carriers (NLCs) have proven to be effective for the delivery of lipophilic drugs by combining high encapsulation capacity with controlled release properties. In this study, NLCs were developed using spontaneous emulsification, a low-energy, simple method that is free of organic solvents. Cetearyl a... |
41768644 | Cooperative Stabilization of Pickering Emulsions by Starch and Chitin Nanoparticles: Roles of Ball-Milling, Gelatinization, Adsorption, and Viscosity Behavior. | We demonstrate enhanced Pickering emulsion stabilization by modified starch nanoparticles (SNP) through their combination with chitin nanocrystals (ChNC). The effect of the biopolymer's ratio on the emulsion stabilization mechanisms was elucidated based on their role at the interface and bulk phases. The stabilization ... |
41768632 | Quantum Biochemistry Insights into Ligand Recognition at the a<sub>1A</sub>-Adrenoceptor. | Understanding the molecular basis of ligand recognition at α<sub>1A</sub>-adrenoceptor (α<sub>1A</sub>-AR) is essential for developing highly selective therapeutic agents. In this study, we applied a quantum biochemistry approach combining density functional theory (DFT) with the molecular fractionation with conjugate ... |
41768629 | MolQuery: Prediction of Lipid Synthesizability Using Active Learning. | In the field of molecular design, Generative Artificial Intelligence (GenAI) has the potential to create extensive synthetic data sets encompassing a wide range of chemical properties. However, the practical application of these data sets is often constrained by the synthesizability of the molecules within. To address ... |
41767962 | Tetranuclear Ag(i) and Au(i) nano-sized [L<sub>2</sub>(R)<sub>8</sub> → M<sub>4</sub>]<sup>4+</sup> (M = Ag(i) and Au(i); R = C<sub>2</sub>H<sub>5</sub>, CH<sub>3</sub>, H, F, Cl, Br, Ph and SiH<sub>3</sub>) complexes: natur... | NHC ligands are able to stabilize different metals in different oxidation states and coordination geometries, making them interesting candidates for the synthesis of potent metal-based anti-cancer agents. This study explores the bonding characteristics and nature of cooperativity in tetranuclear cationic complexes of A... |
41765621 | A ratiometric fluorescent probe consisting of Zn-MOF and calcium ion for sensitive and visual detection of doxycycline. | <h4>Background</h4>The global consumption of antibiotics is steadily rising, with doxycycline being extensively utilized in both animal husbandry and the treatment of COVID-19. Overuse of this antibiotic may result in residual accumulation and pose potential health risks. Conventional detection methods are often comple... |
41757349 | Liquid-liquid phase separation couples MKRN2-mediated ubiquitination of CSDE1 with neurodevelopmental disorders. | <h4>Background</h4>Makorin-2 (MKRN2) is an E3 ubiquitin ligase involved in multiple biological processes, yet its role in neurological disorders remains poorly understood. This study aims to elucidate how MKRN2 regulates the RNA-binding protein CSDE1-a molecule linked to autism-related genes-and to explore the function... |
41756657 | Genome-wide analysis and functional characterization of the <i>SUT</i> gene family associated with stress tolerance in <i>Glycine max</i>. | <h4>Background</h4>Soybean (<i>Glycine max</i>), is a globally important oilseed crop whose yield and quality are severely constrained by environmental stress. The Sucrose Transporter (<i>SUT</i>) gene family plays a crucial role in sucrose transport, plant growth, and stress adaptation. However, comprehensive identifi... |
41756586 | Temperature-responsive hydrogel of oclacitinib maleate administered via the rectum in rabbit. | <h4>Background</h4>The extensive and intense itching caused by skin diseases can significantly diminish the quality of life for companion animals. Oral administration of oclacitinib maleate is recognized as an important treatment for alleviating itching. Oral medications are affected by the animal's temperament and swa... |
41756530 | Advanced multifunctional thermo- and electro-stimulative hydrogels for bone regeneration. | Bone defects caused by trauma, infection, tumors, osteoporosis, and diabetes disrupt skeletal integrity and impair regeneration. The healing process involves inflammatory hematoma formation, callus development, and remodeling, coordinated by diverse cells and signaling pathways. Conventional grafts and inorganic implan... |
41756325 | Honey and cancer: from traditional medicine to modern adjuvant therapy. | Cancer remains one of the principal causes of death worldwide, with conventional treatments like chemotherapy and radiotherapy often exhibiting high toxicity, resistance, and relapse rates. These constraints have sparked new investigation of bioactive phytochemicals as complements to standard therapies, in an attempt t... |
41756300 | Reprogramming tumor immunity through APOBEC3s-mediated mutagenesis: from genome instability to immune checkpoint interactions. | The apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) family was first defined as an innate antiviral defense system, but the APOBEC3 subfamily (APOBEC3s) is now recognized as a major endogenous source of somatic mutagenesis in cancer. APOBEC3s enzymes, particularly APOBEC3A and APOBEC3B, generate chara... |
41756291 | A fully human IgG1 antibody targeting MICA α1 domain inhibits interaction with NKG2D and activates immune effector functions against MICA-expressing cells. | <h4>Background</h4>MICA is a stress-induced ligand for the activating receptor NKG2D and plays a central role in immune recognition and elimination of tumor cells. Tumor-derived soluble MICA (sMICA) and its allelic diversity impair immune responses by disrupting NKG2D function and promoting immune evasion, highlighting... |
41756252 | Double-layer microencapsulation of <i>Lacticaseibacillus rhamnosus</i> using sodium alginate and nano-mucilages of Qodume Shirazi and Camelina sativa for probiotic goat milk dessert. | This study is the first to utilize nano-scale Qodume Shirazi seed mucilage (QSSM) and <i>Camelina sativa</i> seed mucilage (CSSM), individually and in combination, as natural wall materials for microencapsulation of <i>Lacticaseibacillus rhamnosus</i> (LR). SEM analysis indicated smooth bead surfaces and successful ent... |
41756130 | Antimicrobial, anticancer activities and molecular docking of eco-friendly chitosan nanocapsule loaded with biosynthesized titanium nanoparticles by <i>Aspergillus flavus</i>. | <h4>Introduction</h4>Chitosan have been leveraged to create chitosan nanocapsules within a bio-based nanocarrier system, enhancing efficacy and overcoming widespread microbial resistance. To generate chitosan nanocapsules (CNCs) that act as inhibitory agents against pathogenic microbes, this study combined titanium nan... |
41755128 | Optical Waveguide Lightmode Spectroscopy: A Versatile Technique for Real-Time, Label-Free Biosensing. | Optical waveguide lightmode spectroscopy (OWLS) is an integrated-optical technique for probing structures at the solid/gas and solid/liquid interface. Spatial resolution perpendicular to the interface is sub-ångström. Thanks to good time resolution, processes involving structural change can also be investigated. This r... |
41755119 | A Molecularly Imprinted Polymer Electrochemiluminescence Sensor Based on AuNPs@Ru-ZIF-8 for the Rapid Detection of Cyhalothrin Residues in <i>Lycium barbarum</i> L. | <i>Lycium barbarum</i> L. is a widely used medicinal and edible Chinese medicinal material. However, with consumers' heightened concern for health and food safety, pesticide residues have become one of the major challenges affecting its quality and safety. Cyhalothrin is a pyrethroid insecticide and a typical type of p... |
41754969 | Nanoencapsulation of Tomentosin-Rich <i>Pulicaria crispa</i> Fraction in MIL-53(Fe) Improves the Release Profile and <i>In Vitro</i> Anti-Colorectal Cancer Activity. | <b>Background/Objectives:</b> Plant-derived bioactives offer pharmacological potential but are often limited by poor delivery and selectivity. The <i>Pulicaria crispa</i> dichloromethane fraction (DCMF) shows potent but non-selective antiproliferative activity. This study aimed to engineer a functional nanoformulation ... |
41754841 | Rethinking Nature's Pharmacy: AI Era and Natural Product Drug Discovery. | Natural products (NPs) have long been a cornerstone of pharmaceutical innovation, contributing to approximately 50% of FDA-approved drugs over the past four decades. However, traditional NP drug discovery faces significant hurdles, including laborious isolation processes, biodiversity constraints, and low hit rates in ... |
41752595 | Status of Beekeeping Industry in Tanzania: Resources, Practices, and Conservation. | Beekeeping is a widespread economic activity in rural Tanzania, supporting over 2 million livelihoods. The country's forests and woodlands, covering approximately 55% of its land area, provide habitat for an estimated 9.2 million honeybee colonies. This positions Tanzania as the second-largest honey producer in Africa ... |
41751875 | Zinc Coordination by Thymosin β4: Structural Determinants and Functional Implications. | Thymosin β4 (Tβ4) is a highly acidic, intrinsically disordered 43-amino-acid peptide with diverse biological functions, yet its interactions with metal ions remain poorly understood. In this study, we provide the first experimental demonstration that Tβ4 forms discrete Zn<sup>2+</sup>-bound adducts and undergoes Zn<sup... |
41743503 | Screening for novel chemical scaffolds targeting PCNA identifies the Hsp90alpha inhibitor SNX-2112. | Proliferating cell nuclear antigen (PCNA) protein is an emerging therapeutic target for several diseases including cancers, and certain viral infections. It was previously regarded as being undruggable, due to its functions as a molecular hub that regulates a multitude of essential cellular pathways. However, we recent... |
41745974 | Bovine Viral Diarrhea Virus and Vaccine Protection Strategies. | Bovine viral diarrhea virus (BVDV) is a critical pathogen affecting the global cattle industry, causing severe economic losses primarily through persistent infection, immunosuppression, and reproductive failure. The virus exhibits substantial genetic diversity, with marked geographic variation in circulating subtypes, ... |
41744625 | Tetradecylamine: A Newly Identified Biogenic Amine Compound from the Venom of <i>Vespa affinis</i>. | The venom of the Asian hornet (<i>Vespa affinis</i>) comprises a complex mixture of biologically active substances, including various enzymes such as phospholipase A and hyaluronidase; amines such as histamine, serotonin, and catecholamines; peptides such as mastoparan and vespakinin; and other components including ace... |
41726765 | Liposomal J-Aggregates of Indocyanine Green as a Multifunctional Contrast Agent for Photoacoustic Imaging and Photothermal Therapy. | One of the major barriers to further clinical adoption of photoacoustic imaging (PAI) and photothermal therapy (PTT) is a lack of versatile and multi-faceted contrast agents. While indocyanine green (IcG) has gained considerable attention as a promising contrast agent, it is severely limited by rapid clearance time, lo... |
41716672 | Enzyme responsive antimicrobial hyaluronan-nanocellulose hybrid wound dressings for the treatment of infected wounds. | Wound infections pose a substantial clinical challenge and an escalating healthcare burden, further complicated by the rapid increase in multidrug-resistant bacteria. Antimicrobial peptides (AMPs) offer an alternative to conventional antibiotics, but their rapid degradation, hemolytic activity, and potential cytotoxici... |
41716674 | Dynamic hydrogels orchestrate the differentiation fate of mesenchymal stem cells through epigenetic regulation of SETD7 to accelerate bone defect repair. | Dynamic mechanical signaling of the extracellular matrix is a key determinant of mesenchymal stem cell (MSC) fate, closely regulating their proliferation, differentiation and migration. Previously, we developed a highly cell-adaptive dynamic hydrogel (HA-ADA) that modulates MSC fate through unknown mechanisms. Here, us... |
41710583 | Bixin Beyond Colour: Expanding Therapeutic Horizons Through the Integration of Pharmacological Potential with Modern Drug Design and Delivery Strategies. | Bixin, a vibrant apocarotenoid derived from the seeds of <i>Bixa orellana</i> Linn. (commonly known as annatto), has been traditionally used as a natural colorant. However, recent advances have unveiled its diverse pharmacological and therapeutic potential, positioning it as a promising candidate in modern drug discove... |
41710483 | Integrative Computational and Transcriptional Analysis of NF-κB and HIF-1α Modulation Following Doxorubicin Treatment in Triple-Negative Breast Cancer Cells. | <h4>Purpose</h4>Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited targeted treatment options. Doxorubicin remains a cornerstone of TNBC treatment; however, its molecular effects beyond canonical cytotoxic mechanisms are not fully characterized. This study aimed to explore NF-κB- a... |
41710363 | Next Generation Calcium Nanomaterials: Disrupting Tumor Ca<sup>2</sup>⁺ Homeostasis for Enhanced Cancer Therapy. | Calcium-based nanotechnology is a rapidly growing field that leverages the unique properties of calcium compounds at the nanoscale to develop innovative materials and applications. This field centers around the manipulation and utilization of calcium compounds, such as calcium carbonate, calcium phosphate, and calcium ... |
41710365 | Nanocarriers for Psoriasis Treatment: Insights from a Clinical Trial Registered on the Global Clinical Trials Registry Platform. | Psoriasis is a chronic, relapsing inflammatory skin disease. Topical treatments are the primary choice for up to 80% of psoriasis patients; however, their effectiveness is often limited by poor penetration into the skin. Nanocarriers represent a promising advancement in drug delivery systems by enhancing bioavailabilit... |
41710199 | Unlocking spontaneous chiral resolution in silver clusters through steric and anionic control. | The spontaneous emergence of chirality from racemic or achiral small molecules and nanoclusters remains a fascinating yet poorly predictable phenomenon. Herein, we report a rational design strategy for achieving spontaneous chiral resolution, as demonstrated through the controlled synthesis of a series of trinuclear si... |
41702228 | Mitochondrial fusion targeted supramolecular peptide hydrogel for gut neuroprotection. | Oxidative stress-induced enteric neuropathy is a key driver of slow-transit constipation (STC), primarily through disrupted mitochondrial dynamics and neuronal degeneration. To address this, we developed a bioengineered oral delivery system that supports neuronal recovery and actively enhances mitochondrial membrane fu... |
41695101 | Chemical Fingerprinting of <i>Spiranthes spiralis</i> L. Methanol Seed Extract: Spectroscopic, Chromatographic, and Computational Approaches. | In this study, the morphological properties, antioxidant activities, and phytochemical content of <i>Spiranthes spiralis</i> L. seed methanol extracts were characterized and analyzed in silico. Microscopic analysis revealed a fusiform seed shape characterized by prominent basal cells with thick, slanted ridges and poly... |
41694095 | Biphasic dissolving microneedles with cyclodextrin inclusion complexes for enhanced delivery of poorly soluble drugs. | Dissolving microneedles (DMNs) have been widely investigated for transdermal drug delivery, yet their clinical translation and commercialization remain limited, primarily due to insufficient drug-loading capacity. To address this challenge, we developed a high capacity platform by integrating hydroxypropyl-β-cyclodextr... |
41694097 | 6,6'-Biazulenic core as a platform for unlocking Hammett constants <i>via</i> electrochemical free-energy relationships. | Quantitative appreciation of electronic substituent effects is beneficial across the chemical sciences, from reaction kinetics and catalysis to functional materials design and enzymatic processes. While Hammett parameters (<i>σ</i> constants) constitute the most widely invoked paradigm, their determination for structur... |
41694093 | CS-[BiC-PiC]-NiCl<sub>4</sub>: a green and effective heterogeneous catalyst for one-pot synthesis of 2,3-dihydroquinazolin-4(1<i>H</i>)-one derivatives. | In this study, a novel nickel ion-containing dicationic ionic liquid immobilized on chitosan (CS-[BiC-PiC]-NiCl<sub>4</sub>) was designed, synthesized, and fully characterized by using various techniques such as Fourier transform infrared spectroscopy (FT-IR), <sup>1</sup>H NMR and <sup>13</sup>CNMR spectra, X-ray diff... |
41687991 | Electrospun membrane based on chitosan/ polyvinyl alcohol/sulfur-functionalized metal organic framework for efficient removal of Hg(II) ions. | Traditional mesoporous materials and metal-organic framework (MOF) materials encounter bottlenecks such as small particle size, difficulty in recovery, and low mechanical strength in practical applications, which significantly limit their engineering applications in complex water containing-Hg(II) environments. In this... |
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