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41730592 | Preparation of ZIF-8 grafted magnetic solid-phase extraction sorbent for sensitive determination of four cannabinoids in urine and oral fluid. | <h4>Background</h4>The global increase in cannabis use has created a strong demand for reliable and efficient detection methods. Traditional urine-based assays are widely used and standardized, but suffer from complex hydrolysis requirements, long detection windows, and an inability to monitor recent use. In contrast, ... |
41727718 | Structural insights into copper and zinc binding to tau protein and the impact of metal binding on amyloid aggregation. | Tau protein is a microtubule-associated protein central to the pathogenesis of Alzheimer's disease (AD) and other tauopathies. While metal ion homeostasis is disrupted in AD, the presence of copper and zinc in neurofibrillary tangles suggests a pathological role for metal-tau interactions. In this study, the metal bind... |
41716251 | Sugammadex, neostigmine, and postoperative pulmonary complications: protocol of the SNaPP multicentre randomised controlled trial. | <h4>Background</h4>Sugammadex, a novel cyclodextrin reversal agent, reduces the incidence of residual neuromuscular block compared with neostigmine and was associated with fewer postoperative pulmonary complications in a systematic review of small randomised trials. However, evidence from a large RCT is required.<h4>Me... |
41710369 | Oxygenation: Nanotechnological Strategies for Conquering Tumor Hypoxia in Photodynamic Therapy. | Photodynamic therapy (PDT) is a clinically established treatment with high selectivity and minimal invasiveness. However, its efficacy against solid tumors is severely compromised by hypoxia, a hallmark of the tumor microenvironment (TME). Although conventional approaches, such as oxygen delivery and in situ oxygen gen... |
41710281 | Enhancing NK Cell Activity in Colorectal Cancer with an Fc-Optimized Antibody Targeting CD276 (B7-H3). | <h4>Background & aims</h4>Colorectal cancer (CRC) represents a major global health burden due to its high incidence and mortality, particularly in the advanced stages, with limited treatment options. While therapies that block the PD-1/PD-L1 pathway have demonstrated clinical benefit, their success in CRC is largely co... |
41702016 | MnZn bimetallic cold-adapted nanozymes prepared by DBD plasma for in situ monitoring of volatile sulfur compounds and meat freshness inspection. | In this work, low-temperature plasma (LTP) technology was employed to fabricate a novel, cold-adaptive bimetallic MnZn-MOF nanozyme with triple enzyme-like activities. The MnZn-MOF nanozyme could maintain high catalytic activity at nearly 0 °C. The MnZn-MOF nanozyme could be further integrated into agarose hydrogel to ... |
41696597 | A new class of customisable stable boronic ester assemblies. | An efficient, customisable approach for the assembly of covalent macrocycles and cages has been developed using the reaction of fused polynorbornane based bis-diols and commercially available boronic acids. The ability to customise the requisite bis-diol to various lengths and dihedral angles (here both 90° and 180°) a... |
41691763 | A biointerface-engineered gold nanocluster platform for icariin delivery: Dual-pathway modulation of osteoblast and osteoclast dynamics in osteoporosis therapy. | Osteoporosis is a prevalent metabolic bone disorder characterized by an imbalance between bone resorption and formation. Current therapeutic options are constrained by side effects and low bioavailability. Icariin (ICA), a naturally derived osteotropic flavonoid, exhibits osteogenic and anti-osteoclastogenic properties... |
41690229 | Molecular-level design of S-scheme COF/Ce-MOF heterojunctions for efficient photocatalytic H<sub>2</sub>O<sub>2</sub> generation. | In situ synthesis of S-scheme COF/Ce-MOF heterojunctions significantly enhances photocatalytic H<sub>2</sub>O<sub>2</sub> production under ambient conditions. The directional charge separation, precise band alignment, and synergistic dual active sites of the heterojunction enable efficient, stable, and selective H<sub>... |
41690014 | Dual-functional molecularly imprinted polymers for the selective removal and Ultrasensitive FAPA-MS detection of picloram and diclofenac in environmental waters. | This study introduces molecularly imprinted polymers (MIPs) based on a polyethyleneimine (PEI) backbone for their selective removal and detection. To enhance molecular recognition, the PEI was pre-functionalized with 3,4-dichlorophenyl isocyanate (3,4-DCPI) at varying degrees (0-30%) before cross-linking. This signific... |
41689985 | A tetraphenylethylene-based AIE-active supramolecular chemosensor for ultrasensitive detection of Fe<sup>3+</sup>, Cu<sup>2+</sup> and CN<sup/>. | Molecules exhibiting aggregation-induced emission (AIE) characteristics have gained prominence fluorescence in aggregated state, offering distinct advantages compared to traditional fluorogenic probes. This study proposes a hydrazine modified tetrastyrene derivative (Q) with AIE enhancement effect, which is used for hi... |
41687452 | In silico investigation of complexes formed between chemical UV filters and cyclodextrins in water. | UV filter - cyclodextrin complexes are investigated in silico in an aqueous environment using all-atom molecular dynamics simulations in the isothermal-isobaric statistical ensemble. The UV filters considered herein are octocrylene and avobenzone, which are used in commercial sunscreen products and together provide bro... |
41684863 | <i>Brucella</i>'s Emerging Threat: A Global Systematic Review and Meta-Analysis Revealing Temporal, Geographic and Species-Specific Patterns of Antimicrobial Resistance. | Antimicrobial resistance (AMR) can lead to treatment failure in human bacterial infections, resulting in increased morbidity and mortality. Brucellosis is a globally significant zoonotic infection caused by <i>Brucella</i> spp. bacteria, yet the frequency and extent of AMR in <i>Brucella</i> populations from humans are... |
41679640 | Development and validation of a cyclodextrin-based supramolecular HPLC-fluorescence detection method for determining thiabendazole in camel milk from the United Arab Emirates: A comparative study of extraction techniques. | The camel milk industry, increasing over the past decade, has relied on the use of veterinary drugs to maintain safety from parasites. There have been concerns about the levels of thiabendazole, a drug commonly used in camel milk farms, which has been reviewed by the European Commission to set a safe maximum residue li... |
41679545 | Desmoglein 2 (DSG2)-knockout human respiratory epithelial cell model to study species B adenovirus receptor usage. | With an increasing number of human adenoviruses identified, the selection of potential therapeutic vectors broadens. For safety reasons, achieving cell-specific gene delivery is crucial to minimize off-target effects. Therefore, it is essential to gain a systematic understanding of adenovirus receptor-usage. Our aim is... |
41679503 | Ablation of ACSS2 drives alteration to cardiac and hepatic proteomic landscapes in a tissue- and sex-specific manner. | ACSS2 catalyzes the conversion of acetate into acetyl-CoA, linking nutrient availability to cellular processes such as lipid biosynthesis, energy production, and epigenetic regulation. Although ACSS2 has been studied under metabolically stressful conditions, its basal sex- and tissue-specific functions remain poorly de... |
41679482 | Polygonatum sibiricum polysaccharide-based novel triptolide delivery derived from classic compatibility principles in traditional Chinese medicine: Simultaneous renal protection and toxicity attenuation in diabetic nephropathy. | Triptolide (TP) is a bioactive compound with anti-inflammatory, antitumor, and immunomodulatory effects. Its application, however, is limited due to poor aqueous solubility, low bioavailability, and organ toxicity. Based on the classical compatibility theory of Tripterygium and Polygonatum for toxicity reduction in tra... |
41675184 | Preparation of a new BTEAB/DMSO deep eutectic solvent for highly efficient starch dissolution and succinylation. | In this work, a novel deep eutectic solvents (DES) based on benzyltriethylammonium bromide/dimethyl sulfoxide (BTEAB/DMSO) is prepared and described. Comprehensive physicochemical analyses revealed a eutectic point at 0 °C, demonstrating the formation of a highly stable liquid phase characterized by strong intermolecul... |
41675182 | Metal-organic frameworks as effective catalysts for glycerol acetalization: morphology and functionality. | Glycerol is a major by-product generated in large quantities by the biodiesel industry, and its valorisation is essential to promote the usage of this relatively green energy resource. Conversion into fuel additives as solketal <i>via</i> a solvent-free acetalization reaction is one of the most sustainable possible way... |
41671872 | Rapid and recyclable removal of Congo Red dye using mesoporous Zinc-based metal organic framework. | Metal-organic frameworks (MOFs) have emerged as advanced adsorbent materials in wastewater purification because of their high porosity, tunable structure, and exceptional surface area. In the present work, a zinc-based MOF (ZMOF) was prepared via a solvothermal method using zinc nitrate and terephthalic acid. The struc... |
41671657 | An Oxygen-Releasing Mouthwash Reduces Porphyromonas gingivalis Biofilm and Suppresses fimA and hagA Expression. | <h4>Introduction and aims</h4>Porphyromonas gingivalis is a key periodontal pathogen whose biofilm and virulence limit the effectiveness of mouthwashes such as chlorhexidine (CHX). This study evaluated the antibacterial, antibiofilm and virulence effects of an oxygen-releasing mouthwash against P. gingivalis, complemen... |
41668545 | Mitochondrial dysfunction and applications of mitochondrial-targeted delivery systems in atherosclerosis. | Atherosclerosis, a chronic inflammatory disease, is pathologically associated with mitochondrial dysfunction. Mitochondria contribute to oxidative stress, vascular endothelial dysfunction, and chronic inflammatory cascades through pathways such as dynamic imbalance, abnormal epigenetic regulation, disruption of multi-o... |
41668541 | Self-Healing and pH-Robust Hydrogels Enabled by Synergistic Supramolecular Interactions for Injectable Gastrointestinal Wound Repair. | Injectable self-healing hydrogels are promising biomaterials for minimally invasive internal wound repair. However, most hydrogels fail in the gastrointestinal tract, where extreme pH fluctuations, from strong acidity to mild alkalinity, disrupt conventional cross-linking interactions and lead to network dissociation. ... |
41668533 | Design and Characterization of DX-Tile DNA Nanostar-Based Hydrogels. | Pure deoxyribonucleic acid (DNA) hydrogels synthesized via the hybridization of multi-arm DNA tiles (DNA nanostars) are uniquely programmable and functionalizable biomaterials, suitable for applications ranging from biosensing to cell-free protein production and soft tissue engineering. However, the full potential offe... |
41668528 | Synergistic Mn-MOF Activation of Pistol Ribozymes for Cancer Immunotherapy. | Checkpoint blockade therapies targeting PD-L1 have revolutionized cancer immunotherapy, yet their efficacy is constrained by systemic immune toxicity and inadequate immune infiltration in certain tumor types. Here, we introduce a synergistic gene-silencing nanosystem based on a target-selective Pistol ribozyme (PS473) ... |
41668472 | Enhanced Fluorescence in a Metal-Organic Framework via Second-Linker-Induced Suppression of π-π Stacking. | Metal-organic frameworks (MOFs) demonstrate exceptional optical properties, making them promising candidates for applications such as lasers, displays, and organic light-emitting diodes (OLEDs). However, their practical utility is often compromised by π-π stacking interactions and intramolecular motions, which facilita... |
41668435 | Single-Electrode High-Throughput 12-Well Array Electrochemiluminescence Imaging Sensor for Portable Parallel Dual-Color Analysis of Dual Breast Cancer Susceptibility Genes. | Rapid, high-throughput analysis of breast cancer susceptibility genes is essential in a clinical diagnosis. Herein, we designed a 12-well single-electrode electrochemiluminescence (ECL) imaging array biosensor for parallel high-throughput dual-color analysis of dual cancer genes (BRCA1 and BRCA2). Two newly explored lu... |
41668390 | Establishment of an RT-LAMP-CRISPR/Cas12a detection system for grapevine fabavirus and improvement of grapevine leaf crude extract with alkaline resin for on-site naked-eye detection. | <h4>Background</h4>Grapevine fabavirus (GFabV) induces severe chlorosis and malformation in grapevine leaves, and its infection can substantially compromise both fruit yield and quality. Despite its growing impact on viticulture, no rapid and accurate on-site molecular diagnostic tool is currently available for the det... |
41668352 | On the Utility of Infrared Photoactivation for Native Top-Down and Complex-Down Orbitrap Mass Spectrometry of Soluble Proteoform Complexes. | Cellular functions arise from the coordinated action of proteoforms, which typically form multiproteoform complexes (MPCs), rather than functioning as isolated molecular entities. Deciphering the architecture and composition of MPCs is essential for linking proteoform diversity to biological function. Native top-down (... |
41668310 | Fibrous Metal-Organic Framework Membranes with Hierarchical Porous Channels for Efficient Carbon Dioxide Capture. | The structural diversity and facile functionalization of metal-organic frameworks (MOFs) render them promising candidates for carbon dioxide (CO<sub>2</sub>) adsorption and separation. However, the powdery characteristics cause poor mechanical stability and insufficient gas mass transfer, restricting their further appl... |
41668176 | Nanozymes for ATP/cAMP balance restoration and ROS scavenging in inflammatory dermatosis treatment and recurrence prevention. | Inflammatory dermatoses like psoriasis and atopic dermatitis are prevalent autoimmune disorders whose management is challenged not only by inflammatory lesions but, more significantly, by persistent pruritus and frequent relapse following treatment discontinuation. The pathogenic progression of these dermatoses is crit... |
41668148 | Microbial pigments as potential anti-rift valley fever virus drugs. | Rift valley fever virus (RVFV) is among the WHO list of priority diseases, yet no effective vaccine or treatment is currently available. Microbial pigments (MPs) represent a promising small-molecules library which can be exploited for the drug discovery of anti-RVFV compound. In this study, thirteen MPs were in silico ... |
41668145 | Cysteine-Mediated Root Sequestration and Metabolic Reprogramming Alleviate Cadmium Toxicity in Chinese Cabbage. | Cadmium (Cd) contamination poses a serious threat to crop productivity and food safety. Although cysteine (Cys) has been implicated in Cd detoxification, its regulatory role in Chinese cabbage remains poorly understood. Here, we demonstrate that exogenous Cys alleviates Cd toxicity by enhancing root Cd retention and co... |
41668124 | Microbial membrane transporters reveal trace metal niche adaptation in distinct water masses of the Southern Ocean. | <h4>Background</h4>Trace metals are co-factors for enzymes that are essential for microbial metabolism and the cycling of major elements. Membrane transporters allow microbes to sense and react to trace elements in the environment and to balance their uptake and export for the regulation of intracellular metal homeosta... |
41668037 | Biometallic peptide-drug conjugates in photo-crosslinkable hydrogels enable combined photothermal-chemotherapy against breast cancer. | Peptide-drug conjugates (PDCs) offer a powerful therapeutic modality by integrating the targeting specificity of peptides with the cytotoxic efficacy of chemotherapeutics, thereby improving antitumor performance while reducing off-target toxicity. In this study, we engineered biometallic PDCs composed of peptide nanofi... |
41667852 | Recent advances in coacervate protocells from passive catalysts to chemically programmable systems. | This review highlights a clear change in focus in the study of coacervate droplets as protocell models, moving from their role as passive microreactors that concentrate reactants to their function as chemically programmable matter capable of information processing and lifelike behaviors. We use "Input → Written State →... |
41667644 | Structural basis for bat receptor recognition by SARS-CoV-2 and bat SARS2-like coronaviruses. | Coronaviruses evolve to optimize receptor recognition in their natural hosts. A key mystery of COVID-19 is why the SARS-CoV-2 receptor-binding domain (RBD) binds human ACE2 with such high affinity despite limited time for adaptation, while some bat-derived RBDs paradoxically bind human ACE2 more strongly than bat ACE2.... |
41667621 | 2'-O-Methyl-guanosine RNA fragments antagonize TLR7 and TLR8 to limit autoimmunity. | Recognition of RNA fragments by Toll-like receptor 7 (TLR7) and TLR8 helps to initiate the innate immune response against pathogens. An outstanding question is why RNA fragments generated during clearance of apoptotic cells fail to activate TLR7 and TLR8 signaling. Here we show that select 2'-O-methyl (2'-OMe) guanosin... |
41667553 | meso-2,3-dibromosuccinic acid as a temperature-dependent catalyst for the selective synthesis of syn and anti-highly functionalized tetrahydropyridines: experimental and theoretical study. | This study reports the flexible synthesis of syn-anti isomers of highly functionalized tetrahydropyridines under controlled temperature conditions. The present catalytic system employs cost-effective meso-2,3-dibromosuccinic acid in a one-pot, multicomponent process involving both aromatic aldehydes, anilines, and 1,3-... |
41667541 | Antibacterial potential of endophytic Streptomyces spp. isolated from peanut (Arachis hypogaea) roots: bioactiveprofiling and molecular docking studies. | The worldwide escalation of antimicrobial resistance (AMR) necessitates the search for new bioactive agents from natural sources. Consequently, this study investigates the antimicrobial activity of endophytic Streptomyces spp. Eighteen Streptomyces isolates were recovered from sixteen peanut root samples using nitrate ... |
41667537 | Field-tunable charge confinement in III-V layered nanowire-array superlattices. | We present a theoretical framework for electric-field control of charge confinement and interwire tunneling in GaAs/AlGaAs layered nanowire-array superlattices. Using a two-electron effective mass model that incorporates screened Coulomb interaction and experimentally realistic confinement geometries, we investigate ho... |
41667523 | Development of robust dual functioning PPy-based photothermal membranes for simultaneous freshwater and salt harvesting. | Photothermal membranes driven by solar energy represent a promising approach for sustainable and cost-effective desalination and wastewater treatment. Solar energy's renewability and low environmental impact drive its adoption in desalination technologies. In this work, chemical vapor deposition polymerization (CVDP) i... |
41667497 | Dynamic photochromism in cocrystals and tri-state fluorescence switching in films for multilevel optical encryption. | Organic crystalline systems combining dynamic photosalient effect with static photochromism represent a promising class of intelligent responsive materials. In this work, we construct a 3Abf-Ofn cocrystal (3Abf = 3-aminodibenzofuran, Ofn=Octafluoronaphthalene) through molecular co-assembly strategy. Upon UV irradiation... |
41667496 | An integrative structural biology approach reveals the dynamic organization of the R2SP quaternary chaperone complex. | R2SP belongs to the R2TP-like quaternary chaperone family and consists of RUVBL1/RUVBL2 AAA+ ATPases, which powers the machinery, and SPAG1 and PIH1D2 adapter proteins that engage specific clients to promote their quaternary assembly. However, little is known about the structure of R2SP and the precise mode of action o... |
41667483 | An allosteric inhibitor of the Zika virus NS2B-NS3 protease with oral efficacy in mouse models. | The mosquito-transmitted Zika virus (ZIKV) poses a global health threat, with no approved antiviral drugs or vaccines currently available. Here, we report the discovery of a series of ZIKV NS3 protease inhibitors identified through phenotypic high-throughput screening (HTS) using a ZIKV replicon-based cellular assay, a... |
41667482 | Granulomas microenvironment-guided sono-immunotherapy to treat and prevent recurrence of tuberculosis. | Curing tuberculosis (TB) remains challenging due to treatment complexity and high recurrence rates. Through bioinformatic analyses of the immune microenvironment within clinical non-tuberculous granulomas (NTBG)/tuberculous granulomas (TBG) samples, and peripheral blood from drug-resistant/sensitive, recurrent/non-recu... |
41667479 | Enabling water-based high-density nanoparticles assembly by using silk fibroin as an adsorbate. | Water-based fabrication holds promise for innovations in life sciences, electronics, and materials science at the biotic-abiotic interface by integrating living systems with high technologies. However, using water to create bio-nano interfaces is challenging, as it often requires surface pre-treatment and thermal proce... |
41667472 | Rational design and in vivo validation of capsid inhibitors for enterovirus D68. | Enterovirus D68 (EV-D68) is a respiratory virus that causes neurological complications such as acute flaccid myelitis (AFM) and death in children. No vaccine or antiviral is available for EV-D68. We report the structure-based design of the EV-D68 VP1 capsid inhibitors with in vivo antiviral efficacy in a neonatal mouse... |
41667469 | Oxygen depletion in biomolecular condensates is dominated by macromolecular density. | Biomolecular condensates are dynamic cellular compartments formed by the self-assembly of proteins and nucleic acids. Many metabolites partition into condensates based on their interactions with the macromolecular constituents; yet, whether gases behave similarly remains unknown. Here, we show that oxygen partitions in... |
41667464 | Phosphine-mediated hydrogen bond and phosphorescence energy transfer for tunable chiroptical afterglow in stacked polymers. | Polymer-doped chiral organic afterglow (COA) materials represent an emerging frontier in photonics, yet their development is constrained by weak hydrogen bond interactions and limited spectral diversity. Herein, a supramolecular engineering strategy utilizing phosphonic acid-derived directional hydrogen bond networks i... |
41667458 | Degraders of the dengue virus capsid protein exhibit differentiated pharmacology relative to capsid inhibitors. | Due to the limited size of viral genomes, most viral proteins are multifunctional; yet most direct-acting antivirals are designed as single-function inhibitors. The dengue virus (DENV) capsid protein serves as a building block for new virions while also interacting with multiple host factors to remodel the cellular env... |
41667452 | Ultrafast scintillating metal-organic framework films. | Compositionally engineered metal-organic frameworks are designed and used to fabricate ultrafast scintillating films. The inclusion of hafnium ions in the nodes of the metal-organic framework enhances the interaction with ionizing radiation, partially compensating for the low density of the porous material and increasi... |
41667449 | Interpretable and generative deep learning models explicate phase separating intrinsically disordered motifs. | Intrinsically disordered regions (IDRs) in proteins drive phase separation (PS) to form biomolecular condensates, which organize cellular matter. While IDRs are recognized as critical drivers of PS, the systematic identification of sequence motifs governing this phenomenon and their compositional determinants remain a ... |
41667439 | Reactive oxygen species-activated bioorthogonal chemistry in living systems enabled by boronate-caged dihydrotetrazines. | Bioorthogonal chemistry has become a robust toolbox with growing applications in biology and medicine. To meet diverse needs in research, new types of on-demand bioorthogonal reactions capable of responding to biological triggers or exogenous stimuli are highly valuable, to achieve spatial and temporal control over rea... |
41667090 | Orientationally Resolved Electron-Spin Relaxation and Coherence in Fullerene-Encapsulated Rare-Earth Dimers with a Single-Electron Metal-Metal Bond. | Rare-earth dimers with single-electron metal-metal bonds feature strong hyperfine and exchange interactions between metal atoms and an unpaired valence electron. Their stabilization inside carbon cages opens the possibility for applications in quantum information processing and sensing but requires investigation of the... |
41666475 | Micro-gas optical-fiber detection based on metal-organic framework films by photocurable deposition. | Effective detection of dissolved acetylene is critical for diagnosing early faults in oil-immersed power transformers; however, achieving a synergy between high sensitivity and mechanical robustness presents a significant challenge in sensor design. We developed a photocurable composite film comprising copper-based ben... |
41666462 | Lithium-Ion-Induced Structural Constriction of Diatomic Metal-Organic Frameworks Promoting Photo(electro)chemical C-C Coupling. | Electron crowding within the skeletons of metal-organic frameworks (MOFs) has traditionally been overlooked, yet it represents a critical bottleneck in catalytic efficiency. Herein, we present a novel Li<sup>+</sup>-positioning diatomic MOF as a cathodic catalyst to mitigate current crowding during photoelectrochemical... |
41666387 | ChemRefine: An Open-Source Automated and Interoperable Platform for Machine Learning and Quantum Chemistry Simulations. | The role of machine learning in computational chemistry is growing rapidly, promising expedited tasks while improving prediction accuracy. However, the interface of newly developed machine-learned interatomic potentials (MLIPs) with existing computational chemistry workflows based on quantum mechanics (QM) remains a ch... |
41666382 | Amylopectin Copolymers Grafted with RAFT-Obtained Synthetic Polymers: Synthesis and Aqueous Solution Behavior. | According to the requirements of modern society for durable biomaterials with multiple functionalities, the principal target of this study was to apply the "grafting to" scheme on the synthesis of several hybrid copolymers based on amylopectin (AMP) and poly(<i>N</i>-isopropylacrylamide) (PNIPAM), poly(oligo(ethylene g... |
41666376 | Impact of Perfluorinated Organic Acids on Bacterial Ice Nucleators. | Perfluorinated acids such as perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) constitute major environmental pollutants with largely unknown effects on biological ice nucleators (INs), which are crucial for freezing-associated processes in nature. One of the most efficient and abundant INs are bact... |
41666328 | Dithiane-Alkyne Metathesis Enables Trp(C2)-Alkene-Cross-Linked Cyclic Peptides. | Cyclic peptides represent a privileged class of scaffolds in drug discovery owing to their unique balance between structural rigidity and functional diversity. Herein, we disclose an indium(III)-catalyzed intramolecular dithiane-alkyne metathesis (DAM) that facilitates the efficient construction of Trp(C2)-alkene-cross... |
41666315 | One MOF with a New Type of Layer-Pillar Structure and Candy-like Cages for One-Step Purification of C<sub>2</sub>H<sub>4</sub> from C<sub>2</sub> Hydrocarbons. | The separation of C<sub>2</sub> hydrocarbons is crucial yet energy-intensive in the petrochemical industry. This work reports a novel metal-organic framework (MOF), [Zn<sub>2</sub>(BDPO)<sub>0.5</sub>(5-atz)<sub>3</sub>]·2.5DMA·2H<sub>2</sub>O (<b>1</b>) (H<sub>4</sub>BDPO = <i>N</i>,<i>N</i>'-bis(3,5-dicarboxyphenyl)o... |
41666277 | Development of a Paper-Based SERS Platform for On-Site Separation and Detection of Mercury Species in Aqueous Environments. | Accurate identification of mercury species in aqueous environments is essential for assessing ecological and human health risks, given the distinct toxicity and bioaccumulation potential of different mercury forms. Herein, we present a paper-based analytical device that uses electrophoresis and surface-enhanced Raman s... |
41666273 | Zooming into Disease at the Nanoscale: High-Speed Atomic Force Microscopy in Biomedical Discovery. | The dynamic properties of biomolecules are important to the biogenesis of essential building blocks, the maintenance of biological homeostasis, and the cellular responses to external stimuli critical for survival. Structural studies define biomolecular functions, and their dynamic behavior provides mechanistic insights... |
41666266 | PEGylated Heterofunctional Dendrimers Enable Multivalent Diclofenac Delivery for ROS-Driven Anticancer Activity. | Cancer drug development faces escalating costs and limited success, driving interest toward drug repurposing strategies. Diclofenac, a widely used nonsteroidal anti-inflammatory drug (NSAID) with emerging anticancer potential, exhibits poor aqueous solubility and rapid systemic clearance, limiting its chemotherapeutic ... |
41666258 | Self-Healing and Reversible Supramolecular Adhesive Gel with Low-Temperature Resistance. | Adhesive, self-healing, stretchable materials are appealing in emerging scientific and industrial applications. Herein, poly(vinyl alcohol) (PVA)/chitosan (CS)/prenucleation metal-organic framework clusters (preMOFs) hydrogels with boric acid (BA) as cross-linkers, denoted as PSBM gels (PSBM refers to PSB-preMOF-74-Ni,... |
41666256 | High-Throughput Screening Assisted Discovery of Robust Metal-Organic Frameworks for Efficient Ambient NO<sub>2</sub> Removal. | Nitrogen dioxide (NO<sub>2</sub>) is a hazardous air pollutant that poses severe threats to sustainable air pollution control, yet its efficient ambient capture remains a major challenge. Here, we integrate a NO<sub>2</sub>-specific high-throughput computational screening (HTCS) of over 15,000 metal-organic frameworks ... |
41666244 | Mesoscopic Inhomogeneities in Ethanol-Water Mixtures: Are They Nanobubbles, Impurity Aggregates, or Nanoscale Gas-Water Composite Structures? | The study of bulk nanobubbles is a rapidly expanding field, and mixing water with alcohol has been proposed as a simple method for generating such structures. However, previous light-scattering investigations of alcohol-water mixtures have produced inconsistent and often contradictory results. In this work, we employed... |
41666207 | Computational elucidation of stomidazolone mediated inhibition of stomatal differentiation and its implication in plant developmental regulation. | Stomata play a critical role in plant physiology by balancing gas exchange and water conservation. Their development is driven by a precisely orchestrated sequence of cell divisions and differentiation events, regulated by basic helix-loop-helix (bHLH) transcription factors such as MUTE. Previous research reports stomi... |
41666142 | Beyond Cartilage-Inspired Supramolecular Polyurethane for Adaptive Impact-Resistant Protection with Robustness, Self-Healing, and Recyclability. | Conventional ceramic and metallic impact-protective materials are strong yet brittle and heavy, whereas soft materials such as Sylgard 184 and Styrofoam provide limited energy absorption and structural resilience. Achieving high impact resistance together with intrinsic self-healing and recyclability remains a long-sta... |
41665998 | A photosynthetic-respiratory electron transport chain chimera based on photosystem I and cytochrome <i>c</i> oxidase on graphene oxide. | The self-assembly of enzyme proteins on 2D nanomaterials has enabled the construction and functional control of viable biochemical pathways. However, enzymatic cascades, which combine essential components of the photosynthetic and respiratory electron transport chains in tandem, have thus-far remained elusive. Herein, ... |
41665994 | Dual quantum locking: Dynamic coupling of H<sub>2</sub> and H<sub>2</sub>O sublattices in hydrogen-filled ice. | Hydrogen hydrates (HH) are a unique class of materials composed of hydrogen molecules confined within crystalline water frameworks. Among their multiple phases, the filled ice structures, particularly the cubic C2 phase, exhibit exceptionally strong host-guest interactions due to ultra-short H<sub>2</sub>-H<sub>2</sub>... |
41665993 | A systems approach identifies MERTK as a therapeutic vulnerability in ZFTA-RELA-driven ependymomas. | Ependymomas (EPN) are rare central nervous system tumors that account for approximately 10% of intracranial tumors in children and 4% in adults. Despite their clinical and molecular heterogeneity, spanning supratentorial, posterior fossa, and spinal subtypes, treatment remains limited to surgery and radiotherapy, with ... |
41665987 | Learning nature's assembly language with polymers. | The self-assembly of matter into ordered structures is ubiquitous throughout nature and engineered systems. Programming a material's macroscopic properties via molecular-level structural control is a grand scientific challenge, requiring methods for inverse design that can design a targeted molecule to achieve a given ... |
41665956 | A Stable Eu<sup>III</sup> Metal-Organic Framework Sensor for the Fluorescence Detection of Tryptophan and Cancer Biomarker in Living Cells. | Amino acids and cancer biomarkers are crucial for human health and tumor monitoring. The establishment of rapid, accurate, sensitive, and simple detection methods is of great significance for disease prevention, early diagnosis, and therapeutic effect monitoring. Herein, a new three-dimensional metal-organic framework ... |
41665928 | Markov State Models Reveal How hLL-37<sub>17-29</sub> Tetramers Relax from a Disordered State to a Cross-α Amyloid Geometry. | Cross-α amyloids are an emerging class of functional peptide assemblies that underlie biofilm formation and antibiotic resistance in bacteria. Beyond their biological significance, synthetic cross-α architectures exhibit remarkable rigidity and piezoelectric response, positioning them as promising templates for biomate... |
41665626 | Potent neutralization of Rift Valley fever virus mediated by monoclonal antibodies via concurrent inhibition of attachment and fusion. | Rift Valley fever virus (RVFV) is one of the most important mosquito-borne pathogens that causes substantial morbidity and mortality in livestock and humans. Despite its public health and economic impact, no licenced vaccines or therapeutics are currently available for human use. Here, we report the isolation of a pane... |
41665527 | In Situ Heterochiral Helix Coupling Triggered Supramolecular Evolution. | In situ precise matching of chiral structures (e.g., stereocomplementary pairs between secondary structures of proteins) is essential for directing the evolution of biostructures. To date, static construction of diverse stereoselective pairs (parallel homochiral or heterochiral helical array, homochiral double/triple h... |
41665519 | All-Solution-Processed Sky-Blue Perovskite Electroluminescence Device via Integrated Supramolecular Host-Guest Post-Treatment. | All-solution-processed perovskite optoelectronic devices are promising for scalable, sustainable manufacturing, yet their performance remains inferior to vacuum-deposited counterparts because solvents used for subsequent charge transport layers often damage the underlying emissive layer. Herein, we find that when fabri... |
41665471 | Programmable Biohybrid Probiotics with Long-Term Storage Stability for Enhanced Intestinal Microbiota Regulation and Ulcerative Colitis Treatment. | Ulcerative colitis (UC) is a chronic inflammatory bowel disease with limited therapeutic options and high relapse rates. Live bacterial therapeutics (LBTs) offer a promising alternative by restoring mucosal integrity, modulating immunity, and rebalancing gut microbiota; however, their clinical translation is constraine... |
41665431 | Rational Design of Bimetallic Cobalt-Copper Sulfides with Enhanced Reaction Kinetics and Suppressed Shuttle for High-Performance Sodium-Ion Batteries. | Development of advanced anodes for sodium-ion batteries (SIBs) remains challenging due to the sluggish kinetics and severe volume expansion. Here, we report the rational design of bimetallic Co/Cu sulfides embedded in N/S-doped carbon matrices, via chemical vapor sulfurization of MOF precursor. The optimized CuCo<sub>2... |
41665146 | Biomimetic Selenium-Encrusted Prussian Blue Nanozyme for Myocardial Infarction by Coordinated Enhancement of Mitophagy and Reactive Oxygen Species Scavenging. | The vicious cycle between reactive oxygen species (ROS) burst and impaired mitochondria represents a core pathological driver in myocardial infarction (MI). Synergistically promoting ROS scavenging and enhancing mitophagy to achieve dual restoration of redox homeostasis and energy metabolism are crucial for the effecti... |
41665118 | Toward Reconciling the Standard Binding Free Energy of Lenacapavir to HIV-1 Capsid with Experiment: Thermodynamic Effects of Solvent Buffer and Ligand Reorganization. | We report a large thermodynamic effect of solvent buffer on the standard binding free energy for a large hydrophobic ligand and show that a realistic comparison with the experimental binding affinity requires correctly accounting for the solvent reference state and ligand reorganization. We focus on lenacapavir (LEN; M... |
41665088 | Anomeric Amides: Valuable Reagents in Synthetic Organic Chemistry. | The quest for synthetic tools to achieve molecular complexity is of paramount importance. In recent years, strategies have been developed for the late-stage functionalization of molecules. Anomeric amides have emerged as valuable reagents in this active research area due to their broad range of synthetic applications, ... |
41664936 | A Hyperthermostable Archaeal GH78 Rhamnosidase Efficiently Hydrolyzes Flavonoid Glycosides for Juice Debittering. | α-L-Rhamnosidases are a class of glycosyl hydrolases (GHs) that catalyze the hydrolysis of terminal α-L-rhamnose residues from diverse glycoconjugates. While extensively characterized in bacterial and fungal sources, no archaeal α-L-rhamnosidases have been characterized to date. Herein, we report the identification and... |
41664914 | The pyrogenic mediator prostaglandin E<sub>2</sub> elicits warmth seeking via EP3 receptor-expressing parabrachial neurons: a potential mechanism of chills. | Seeking warmth during infection is a sickness behaviour that contributes to the development of fever and is often accompanied by chills. However, the central mechanism underlying this behaviour remains unknown. We recently reported two ascending thermosensory neuronal pathways from the lateral parabrachial nucleus (LPB... |
41664861 | A Trimetallic NiZrCu-Metal-Organic Framework Nanosheet for Superior Peroxymonosulfate Activation. | Incorporation of redox-active metal ions with positive synergism in Two-dimensional (2D) metal-organic frameworks (MOFs) is a promising strategy for the creation of highly electroactive catalytic sites with high accessibility. This study reports the ultrasonic-assisted synthesis of novel 2D trimetallic NiZrCu-MOF nanos... |
41664853 | Uncovering Design and Assembly Rules for mRNA-DNA Origami. | mRNA-DNA hybrid origami enables integration of the RNA functionality into programmable DNA nanostructures, yet robust design and assembly rules remain lacking. Here, we systematically define parameters governing the high-yield formation of compact mRNA-DNA hybrid origami. Using mature mRNAs encoding firefly luciferase,... |
41664834 | Unravelling Non-Peptidic Analogues as Phe-Phe Mimetics: Insights into Synthesis, Self-Assembly, Structural Analysis, and Optical Properties. | The diphenylalanine (FF) and its derivatives are widely studied for their self-assembly, mechanical strength, and diverse applications in materials and the biomedicine field. To develop a stable, and synthetically accessible nonpeptidic FF mimic, 14 aromatic derivatives of l-phenylalanine (A1 to A7) and l-phenylglycine... |
41664582 | Construction and Microenvironment Regulation of Short Charge Transfer Tunnel at MOF/COF Heterointerfaces for Visible-Light-Driven Hydrogen Evolution. | Raising electron transfer efficiency is a crucial issue in improving photocatalytic productivity. Herein, we propose a strategy for anchoring single atoms and the establishment of a short-distance electron transport pathway. By incorporating nitrogen-containing monodentate ligands into UIO-66-NH<sub>2</sub>, Pt single ... |
41663482 | Facile fabrication of porous Bi<sub>x</sub>S<sub>y</sub>/Si photodetectors by one step laser ablation in liquid. | In this study, facile bismuth sulfide (Bi<sub>x</sub>S<sub>y</sub>) porous nanostructures (NSs) were synthesized by the liquid-based pulsed laser ablation (PLAL) method. The Bi<sub>x</sub>S<sub>y</sub> nanostructures were formed by laser ablation of the bismuth (Bi) target within 1 M of thiourea [SC (NH<sub>2</sub>)<su... |
41663402 | Cryogenic transmission electron microscopy reveals assembly and nanostructure of PEDOT:PSS. | Soft and conducting organic materials are ideal candidates for stretchable bioelectronics and wearable devices. Despite recent advances, our understanding of conducting polymer nanostructures and how they arise remains incomplete, given the limited high-resolution studies and molecular-level descriptions of these syste... |
41663366 | Extraocular delivery of bioswitchable tri-miR-22-loaded tetrahedral DNA nanostructures for intraocular neovascular and neurodegenerative repair. | Ocular neovascular and neurodegenerative diseases, such as diabetic retinopathy and age-related macular degeneration, are characterized by abnormal angiogenesis, vascular leakage, and progressive retinal neurodegeneration, ultimately leading to irreversible vision loss. Here, we present a tetrahedral framework DNA-base... |
41589573 | A stable yttrium-based metal-organic framework built on ladder building units for size-exclusion separation of hexane isomers. | The separation of hexane isomers represents a critical industrial process, which remains challenging due to their similar physicochemical properties. In this study, we report a three-dimensional (3D) Y-based metal-organic framework (MOF), [Y<sub>2</sub>(μ<sub>3</sub>-F)<sub>2</sub>(TBTC)(2-FBA)·1.5DMF]{denoted as HIAM-... |
41574920 | Optimal Mn doping for enhanced photothermal conversion performance in Prussian blue@layered double hydroxides. | Near-infrared (NIR)-responsive photothermal materials are critical for solar energy conversion, yet conventional materials face limitations in efficiency, stability, and spectral tunability. Herein, we report Mn-doped Prussian blue intercalated MgAl-layered double hydroxides (Mn-PB@LDHs), synthesized <i>via</i> a separ... |
41567003 | Tuning photocatalytic CO<sub>2</sub> reduction reaction performance <i>via</i> nodes and dimensionality in metal-organic frameworks. | This work details the synthesis of a 3D MOF, Co3-MOF-3, from two precursors: a 1D chain (Co1-MOF-1) and a 2D layer (Co8-MOF-2), linked <i>via</i> single-crystal-to-single-crystal transformation. Notably, the 2D precursor, Co8-MOF-2, demonstrated exceptional activity for photocatalytic CO<sub>2</sub> reduction, with a r... |
41566948 | Temperature-controlled synthesis of MOF-derived Ni<sub>3</sub>S<sub>2</sub>/C nanocomposites for high-performance supercapacitors. | Supercapacitors have emerged as a crucial class of energy storage devices due to their high power density and long cycle life. However, the development of electrode materials that combine high specific capacitance and robust stability remains a challenge. In this work, two-dimensional (2D) Ni-based metal-organic framew... |
41562229 | A polyoxovanadate-based metal-organic framework unlocks the potential for advanced calcium-ion storage. | To mitigate kinetic barriers induced by the high charge density of Ca<sup>2+</sup>, we engineered a Co,V-POMOFs/GO hybrid. Synergizing multi-electron redox POMs and stable MOFs with volume-buffering GO, this cathode delivers 320.45 mAh g<sup>-1</sup> at 50 mA g<sup>-1</sup> with extended cycling stability, establishing... |
41562224 | Cyclotriveratrylene-engineered 2D conductive metal-organic framework for sensitive electrochemical detection of hydrogen peroxide. | Exploiting the excellent solubility of bowl-shaped hexahydroxycyclotribenzylene (HCB) enabled rapid assembly of a layered HCB-Cu framework. This system synergistically utilizes its electron-rich cavity for host-guest recognition and its conjugated network for efficient electron transfer, enabling sensitive H<sub>2</sub... |
41556327 | Chiral organization of tetraphenylethylenes mediated by multivalent hydrogen bonding. | Tetraphenylethylene (TPE)-based chiral supramolecular assemblies with chiroptical activity were constructed <i>via</i> the cooperative polymerization of multivalent hydrogen-bonding monomers. By employing these fluorescent supramolecular assemblies as energy donors and introducing Nile red (NiR) as the acceptor, an aqu... |
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