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41532493 | Bridging the hydrophobic gap: visible-light-driven photocatalysis of organic reactions in water with soft-matter nanoreactors. | Visible-light-driven photocatalysis of organic reactions in water represents a cornerstone of green chemistry, yet its application is often hampered by the poor solubility and stability of organic substrates and catalysts in aqueous media. In this review article we highlight recent advances in overcoming these challeng... |
41532187 | Dynamic thiol-disulfide exchange regulated protein assembly for adaptive and functional material design. | Achieving controlled, ordered, and dynamic protein assembly <i>in vitro</i> remains a major challenge in supramolecular chemistry. Dynamic thiol-disulfide exchange, a key reaction in biology, has recently emerged as a versatile and programmable tool for constructing adaptive protein-based materials. In living systems, ... |
41959874 | Quantum refinement with electron diffraction and X-ray free-electron laser data: comparative study of ribonucleotide reductase dimetal site. | Quantum refinement (QR) is an approach in which the empirical restraints used in standard structural refinement to ensure that the details of the structure, <i>e.g.</i> bond lengths and angles, make chemical sense are replaced by more accurate quantum mechanical calculations for a small but interesting part of the stru... |
41908308 | CasMiner: a deep-learning tool for high-throughput mining and rational design of efficient Cas9. | Since its inception, the CRISPR-Cas system, particularly Cas9, has demonstrated immense potential for life science applications, but expansion of the Cas9 toolkit is constrained by sequence-alignment-based strategies for mining and optimization. Here, we developed CasMiner-a deep-learning model for discovering and engi... |
41847639 | Novel Macrocyclic Compounds Targeting KRAS Mutations for Cancer Treatment. | This patent provides novel macrocycle compounds that inhibit key mutants (G12D/G13D) of the KRAS oncogene, which is the most frequently mutated in human cancers. These compounds, along with their pharmaceutical compositions and protein complexes, are intended for the treatment of cancers driven by these mutations. |
41799416 | Mechanisms of tumor cell evasion from NK cell-mediated killing and advances in NK cell-based cancer immunotherapy. | Natural killer (NK) cells represent a critical component of the innate immune system, capable of exerting potent cytotoxic activity against infected and transformed cells. However, tumor cells evolve diverse strategies to evade NK cell-mediated surveillance, including modulation of receptor-ligand interactions, secreti... |
41783647 | Synthesis, Properties, and Applications of Morphology-Controlled Perovskite Quantum Dots. | Lead halide perovskite quantum dots (QDs) have become a promising class of nanomaterials due to their simple, scalable synthesis and high luminescence efficiency. However, their high ionicity and low lattice formation energy make controlling the synthesis of perovskite QDs particularly challenging. Although there have ... |
41777634 | Cyclodextrins improve grape must fermentability through their detoxifying effect on medium-chain fatty acids. | Through their inhibitory effects on yeast metabolism, medium-chain fatty acids (MCFAs) are one of the most frequent causes of stuck and sluggish fermentations (especially white grape must fermentation) in winemaking. A common strategy in winemaking to mitigate or correct the inhibitory effects of medium-chain fatty aci... |
41768701 | Robust Hydrogen-in-Oxygen Sensing in Alkaline Water Electrolysis via Hydrophobic MoS<sub>2</sub> Interface Engineering. | Alkaline water electrolysis (ALK) is a promising route for large-scale green hydrogen production, but hydrogen-oxygen mixing during operation poses severe explosion risks, requiring reliable hydrogen-in-oxygen monitoring. Existing sensors suffer from degraded performance under ALK conditions (80-95 °C, 30% KOH) due to ... |
41768646 | Quenching Single-Fluorophore Systems and the Emergence of Nonlinear Stern-Volmer Plots. | Reduction in fluorescence intensity upon addition of quencher molecules is often quantified by the Stern-Volmer equation. Central to the underlying model is the formation of an adduct between quencher and excited state (dynamic quenching), or ground-state (static quenching), fluorophore at steady-state conditions. Assu... |
41768661 | Evaluating Hybridization Chain Reaction to Improve miRNA Measurements at Portable Electroanalytical Strip: miRNA-21 as a Case of Study. | This work reports on the evaluation of the hybridization chain reaction recognition system to be combined with a frugal sensing platform, namely screen-printed electrode, for the measurement and the amplification of circulating nucleic acids, without the use of time-consuming and complex procedures. In fact, if traditi... |
41755864 | Intermolecular Stacking-Instructed Chiral Preference in Covalent 2 + 2 Macrocyclization. | We report the discovery of unexpected chiral preferences in 2 + 2 macrocyclization, where a racemic pair of 2,6-pyridine-(dicarbonylamino-acid)-hydrazides or two equiv of the meso analogue are reacted with two molecules of achiral, structurally symmetric bidentate, 1,4-pheylenediisothiocyanate. Using racemic alanine (A... |
41752380 | β-Glucuronidase at the Microbiota-Host Interface: Dual Regulatory Roles and Precision Modulation by Natural Products. | Gut microbial β-glucuronidase (GUS) plays a pivotal role at the microbiota-host interface by hydrolyzing glucuronide conjugates, thereby influencing xenobiotic metabolism, enterohepatic circulation, and systemic homeostasis. Dysregulated GUS activity has been increasingly linked to adverse health outcomes, including dr... |
41752378 | 2-Hydroxypropyl-β-Cyclodextrin-Based Complexes Improve Polyphenol Solubility and Bioaccessibility: Evaluation by Validated HPLC-DAD Method. | Propolis is a rich natural source of biologically active polyphenols; however, their therapeutic potential is often limited by poor oral bioaccessibility and bioavailability. This study reports the development and validation of a high-performance liquid chromatography-diode array detector (HPLC-DAD) method optimized fo... |
41750819 | Cyclodextrins-Assisted Extraction for the Recovery of Bioactive Compounds from Rosemary Post-Distillation Residues-In Vitro Antioxidant Activity, Comparisons to Conventional Liquid Extracts. | This study investigated the valorization of rosemary (<i>Rosmarinus officinalis</i> L.) post-distillation residues-by-products derived from essential oil production-using cyclodextrins (CDs) as green co-solvents for the efficient extraction of bioactive compounds. This work aimed to explore key extraction parameters, i... |
41750816 | Effects of Grapevine Leafroll-Associated Virus 3 on the Chemical and Sensory Properties of Cabernet Sauvignon Grape and Wine. | Grapevine leafroll-associated virus (GLRaV) is a globally widespread disease that causes substantial economic losses in the wine industry. In severely affected vineyards, GLRaV can reduce grape yield by 20-40%. This study aimed to evaluate the effects of GLRaV infection on polyphenolic and volatile organic compound con... |
41745026 | Cellulose-Rich Polysaccharide Extracts with Gel-Forming Potential and Improved Antioxidant Properties from Stem (<i>Vitis vinifera</i> L.) By-Products: Ultrasound-Assisted Aqueous Extraction and Characterization. | The valorization of wine by-products aligns with circular bioeconomy principles. This study investigates the ultrasound-assisted aqueous extraction (UAE) of bioactive compounds and cell wall polysaccharides from Syrah grape stems (<i>Vitis vinifera</i> L.) to produce polysaccharide extracts with the intrinsic potential... |
41743657 | Emerging inorganic nanomaterial-based electrochemical sensors for heavy metal detection in food: Advances, challenges, and prospects. | The review focuses on the application of inorganic nanomaterial-based electrochemical sensors in heavy metal detection in food, systematically outlining their technical principles, performance challenges, and development prospects. Heavy metals are among the most concerning food contaminants due to their high toxicity ... |
41737829 | Exploring the gut microbiota-microbial metabolites-targets regulatory network in metabolic dysfunction-associated steatotic liver disease. | <h4>Background</h4>Metabolic dysfunction-associated steatotic liver disease (MASLD), which has emerged as a significant global public health concern. The regulatory role of gut microbiota and their metabolites in the pathogenesis of MASLD has attracted significant attention.<h4>Methods</h4>Mendelian randomization (MR) ... |
41737726 | Sex-informed estrogen receptor modulation in schizophrenia: a male-focused ERβ/GPER1 framework for cognitive and negative symptoms. | Treatment-resistant schizophrenia (TRS) remains a major unmet clinical need, particularly in males who exhibit more severe negative and cognitive symptoms and limited responsiveness to dopamine-based therapies. Estrogenic signaling-especially through estrogen receptor beta (ERβ) and the G-protein-coupled estrogen recep... |
41737687 | Establishment of a droplet digital PCR detection method for Vp4 gene of PoRV. | Diarrhea outbreaks in pigs occur most frequently during winter, porcine rotavirus (PoRV) is one of the important diarrheal diseases. Droplet digital polymerase chain reaction (DDPCR), a detection method that can perform absolute quantification of genes. The study aimed to diagnose PoRV infection using a probe-based DDP... |
41737548 | Drug resistance mechanisms in <i>Mycobacterium tuberculosis i</i>nfection and challenges in vaccine development. | Drug-resistant <i>Mycobacterium tuberculosis</i>(Mtb) has become a global public health crisis, and its diverse drug resistance jointly reduces the effectiveness of antibacterial drugs. Mtb resistance is not merely genetic but involves a synergistic interplay of cell wall remodeling, metabolic reprogramming, and epigen... |
41737496 | Unlocking binding properties of single-domain antibodies targeting the polymeric immunoglobulin receptor to enhance mucosal enrichment of IgG against respiratory syncytial virus. | A major driver of mucosal immunity is immunoglobulin A (IgA) that can translocate across mucosal epithelial barriers to protect against various pathogens in luminal spaces of the human body. The transcytosis of IgA is primarily mediated by the polymeric Ig receptor (pIgR), which is highly expressed in mucosal tissues a... |
41737395 | Fecal microbiota transplantation improves functional constipation through the gut microbiome-bile acid-receptor axis. | Functional Constipation (FC) is a prevalent gastrointestinal motility disorder worldwide that markedly impairs patients' quality of life, yet the currently available treatment options often show limited efficacy. In recent years, research has gradually revealed the critical role of the gut microbiota and bile acid meta... |
41737343 | Targeting cancer hallmarks using resveratrol: isolation, formulation, and mechanisms of action. | Natural products, particularly medicinal plants, play a crucial role in combating cancer and developing new treatments due to their unique properties, such as diverse chemical structures, low toxicity, and the ability to target various types of cancer. They offer a promising approach for the treatment and prevention of... |
41737203 | Research advances on NLRP3 inflammasomes in organ transplantation. | Organ transplantation is a life-saving therapy for end-organ failure; however, long-term outcomes are limited by complications such as ischemia-reperfusion injury (IRI), allograft rejection, and infection. The NLRP3 inflammasome, a key innate immune signaling platform, plays a central role in driving inflammation in th... |
41737010 | Characterization and anti-inflammatory studies of supramolecular assemblies of chlorogenic acids with metal ions. | <h4>Introduction</h4>Self-assembled natural small molecules are believed to have numerous potential applications, particularly in the material and pharmaceutical industries, as self-assembly increases the anti-inflammatory, antitumor, antiviral, and other biological activities. In this study, we synthesized more potent... |
41737011 | Progress, critical challenges, and translational prospects of intranasal administration of botanical essential oils for the treatment of depression. | Depression is a highly prevalent and disabling psychiatric disorder worldwide. However, currently available first-line antidepressant therapies are frequently limited by delayed onset of action, a high incidence of adverse effects, and inconsistent therapeutic efficacy, underscoring the urgent need for alternative trea... |
41736794 | An integrative ultrastructural and transcriptomic analysis of host-pathogen interactions with human brain microvascular endothelial cells during cryptococcal infection: a preliminary study. | <h4>Background</h4>In humans, <i>Cryptococcus neoformans</i> and <i>Cryptococcus gattii</i> species complexes are the leading cause of fungal meningitis globally. To establish CNS infection, <i>Cryptococcus</i> must breach the BBB, primarily comprised of specialized brain microvascular endothelial cells (BMECs), which ... |
41736770 | Advances in endothelial cell targeting by AAV vectors. | Adeno-associated virus (AAV) vectors have become a cornerstone of <i>in vivo</i> gene delivery. However, although the endothelium is the first cellular interface encountered after systemic delivery, native AAV serotypes exhibit poor endothelial transduction, favoring hepatocytes, muscle cells and, neurons instead. This... |
41732390 | Data-driven multiscale design of composite biomaterials: Integrating experiments, imaging, and computational modeling for biomedical engineering. | Composite biomaterials are central to biomedical engineering, where implants and scaffolds must simultaneously meet mechanical, biological, and functional demands across length scales. This review outlines a data-driven multiscale design paradigm that unites experiments, three-dimensional imaging, and computational mod... |
41732171 | Sublimation aides and abets co-milling and discoloration involving quinhydrone. | We report an application of co-milling to the binary cocrystal <b>(BZQ)·(HQ)</b> or commonly known as quinhydrone. The co-milling is performed with either <i>trans</i>-bis(4-pyridyl)ethylene <b>(4.4'-BPE)</b> or 4-methoxyaniline <b>(4-MA)</b>. In both cases, the dark green color of <b>(BZQ)·(HQ)</b> in the sample under... |
41717630 | Decoding Tocopherol-Polyphenol interactions in oil-in-water emulsions through combined WIM-CAT and CV assays. | The antioxidant interactions of α- and γ-tocopherol with curcumin and quercetin were assessed in an oil-in-water emulsion using the WIM-CAT assay, a method integrating Weibull interaction modeling with the conjugated autoxidizable triene technique. Synergistic effects were strongest for γ-tocopherol with curcumin and f... |
41717492 | Metabolic and transport engineering enable efficient de novo biosynthesis of patchoulol in <i>Saccharomyces cerevisiae</i>. | Patchoulol is a valuable sesquiterpene for fragrance and cosmetics, but plant extraction is slow and resource-intensive. Here, we combined enzyme, pathway and transporter engineering to build a yeast chassis for high-titer patchoulol production. Semi-rational engineering of patchoulol synthase (PTS) increased catalytic... |
41717083 | β-Hydroxybutyrate attenuates glycation-induced structural destabilization and amyloidogenic aggregation in human serum albumin. | Protein aggregation and amyloid fibril formation are key events in neurodegenerative disorders such as Alzheimer's disease, and are worsened by non-enzymatic glycation, which destabilizes protein structure. Glycation by reducing sugars like glucose produces advanced glycation end products (AGEs), promoting misfolding a... |
41716349 | Fmoc-DDT@Fos hydrogel mitigates temporomandibular joint osteoarthritis through regulating macrophage reprogramming and ferroptosis. | Temporomandibular joint osteoarthritis (TMJ OA) represents a progressive degenerative disorder that seriously threatens patients' quality of life. Current treatment aims to slow cartilage degeneration, relieve pain, promote bone remodeling, and restore joint function. In this study, we develop a novel peptide hydrogel ... |
41710203 | Deciphering the guest-free crystal structures and thermal breathing of the flexible metal-organic frameworks ZIF-7 and ZIF-9. | Owing to their dynamic phase behaviour and unique gas sorption properties, flexible metal-organic frameworks (MOFs) have emerged as a promising class of materials for applications in gas-related technologies and beyond. Resolving the crystal structures of the distinct phases is essential for understanding their transfo... |
41705143 | Advancing nanolithography: a comprehensive review of materials for local anodic oxidation with AFM. | Local anodic oxidation (LAO), also known as local oxidation nanolithography or oxidation scanning probe lithography has emerged as a versatile technique for nanoscale patterning, leveraging the precision of scanning probe microscopy, relying specifically on atomic force microscopy. This review explores the materials ut... |
41704600 | Noncoding RNAs and the phytochemical economy: Molecular regulators of secondary metabolism in medicinal plants. | <h4>Background</h4>Medicinal plants produce specialised (secondary) metabolites including alkaloids, terpenoids, flavonoids and phenolics that underpin pharmaceuticals, nutraceuticals and traditional therapeutics. Although enzyme-encoding genes and transcription factors are established regulators of these pathways, acc... |
41704232 | Artificial intelligence virtual extracellular vesicles (AIVEVs). | Recent progress in artificial intelligence (AI) has given rise to AI virtual cells (AIVCs), which are digital twins of predictable or dynamic biological cells. This model can simulate, predict and replicate the behavior of real cells in digital software. Extracellular vesicles (EVs) are nanoscale phospholipid bilayer s... |
41702220 | Hydroxamic acid chelator profiles and Ga(III) complexes from siderophore synthetase-mediated synthesis using length-modulated substrates. | The recombinant Salinispora tropica CNB-440 siderophore synthetase StDesD catalysed the assembly of pools of hydroxamic acid-containing chelators from a set of linear, non-native substrates containing internal polyethylene glycol (PEG)<sub>n</sub> spacer units. The internal (PEG)<sub>n</sub> units were capped at each e... |
41702021 | Investigation of enantioselective differences of chiral deep eutectic solvents based on natural organic acids with different configurations in capillary electrophoresis. | Due to the unique physicochemical properties, deep eutectic solvents (DESs) have been becoming a promising alternative to conventional organic solvents and ionic liquids. DESs have attracted extensive attention in the field of chiral separation. At present, there are few reports on the enantioselective differences of D... |
41696593 | Ordered perovskite nanocrystals: a transformative platform for optoelectronic applications. | Perovskite nanocrystals (PNCs) have emerged as a versatile platform for next-generation optoelectronics owing to high photoluminescence quantum yields, tunable bandgaps, and superior charge transport. Yet, the intrinsic disorder of colloidal systems and limitations of scalable processing severely restrict their perform... |
41696596 | A chiral co-assembled exciplex host achieved extremely outstanding narrowband circularly polarized electroluminescence. | High-performance circularly polarized organic light-emitting diodes (CP-OLEDs) that can simultaneously achieve narrowband emission and high electroluminescence asymmetry factor (<i>g</i> <sub>EL</sub>) values remain a formidable challenge. In this study, a simple strategy utilizing a co-assembled chiral exciplex as a h... |
41691867 | Investigation of the growth mechanism of Cu(I)-based MOFs on Cu<sub>2</sub>O nanoparticle surfaces and their application in electrocatalytic CO<sub>2</sub> reduction. | Metal-organic frameworks (MOFs) are a class of materials renowned for their unique porous architectures, tailorable ligands, and versatile metal nodes. They have garnered substantial attention owing to their promising applications in gas storage/separation and catalysis. Notably, core-shell composites fabricated using ... |
41690233 | A polyphenol-engineered interfacial framework enables aeration-free electro-Fenton via localized oxygen enrichment. | The practical application of the electro-Fenton (EF) process for antibiotic degradation is severely hampered by the sluggish mass transfer of dissolved oxygen, fundamentally coupling its performance to inefficient bulk aeration. Here, we overcome this limitation by proposing a "Localized Oxygen Enrichment Framework" (L... |
41690119 | Disarming bacterial iron homeostasis and sulfur antioxidant defenses via coordination-driven photosensitizer de-aggregation for enhanced photodynamic infection eradication. | Antibacterial photodynamic therapy (PDT) offers a resistance-proof strategy for bacterial elimination via reactive oxygen species (ROS). However, its efficacy is hindered by intrinsic bacterial oxidative stress tolerance. Furthermore, clinically relevant photosensitizers such as chlorin e6 (Ce6) suffer from aggregation... |
41687295 | From biosensing to herbal discovery: A nanozyme cascade platform for acetylcholinesterase monitoring and inhibitor screening in synthetic and natural sources. | Early diagnosis and therapeutic intervention for Alzheimer's disease (AD) necessitate advanced tools for detecting acetylcholinesterase (AChE) activity and screening AChE inhibitors (AChEIs). This study developed a novel bimetallic MOF nanozyme, Cu-NH<sub>2</sub>-88B(Fe), exhibiting significant peroxidase-like activity... |
41684454 | LINC00973/DTX3L Axis Promotes Non-Small Cell Lung Cancer Progression and Serves as a Therapeutic Target. | Long non-coding RNAs (lncRNAs) constitute a critical class of regulatory molecules involved in cancer biology and play pivotal roles in tumor initiation and progression. Nevertheless, the biological functions of many newly identified lncRNAs in non-small cell lung cancer (NSCLC), as well as their potential therapeutic ... |
41678902 | A core-shell upconversion nanoparticle@copper-porphyrin metal-organic framework for near-infrared light-triggered synergistic antibacterial treatment. | The escalating crisis of antimicrobial resistance demands innovative antibacterial strategies. To address the limitations of conventional photodynamic therapy (PDT), such as poor tissue penetration of light and hypoxic microenvironments, we developed a core-shell nanocomposite (UCNP@MOF) integrating upconversion nanopa... |
41678853 | Preparation of Ag-MOF based high-performance SERS substrate for the rapid detection of paraquat in plasma. | Paraquat (PQ) is the herbicide that has been proven to be harmful to humans and poses significant risks. Rapid and accurate determination of PQ in clinical practice would aid in the correct diagnosis and timely treatment of patients with PQ poisoning. This study aims to utilize surface-enhanced Raman spectroscopy (SERS... |
41675484 | Racial and Ethnic Disparities in the Use of Expensive Medications: A Focus on Sugammadex in the Pediatric Perioperative Setting. | <h4>Introduction</h4>Avoiding residual neuromuscular blockade in the postoperative period sparked interest in the use of sugammadex as a reversal agent. However, because sugammadex was considered more expensive than other commonly used medications for this purpose, it was crucial to investigate potential disparities in... |
41674924 | Causal Association Between Plasma Proteins and Pericarditis: A Mendelian Randomization Study With Therapeutic Target Identification. | <h4>Background</h4>Observational studies demonstrate that pro-inflammatory cytokines play a critical role in pericarditis. However, the causal association between circulating plasma proteins and pericarditis remains unestablished.<h4>Objective</h4>This research aimed to assess the causal association between plasma prot... |
41669561 | Nanoengineered Photoactive Micromotors for Targeted Pollutant Capture, Degradation, and SERS-Based Detection. | Achieving both selective pollutant degradation and real-time detection within a single micromotor system remains challenging for environmental monitoring. To address this limitation, we engineered gold-nanostar-decorated, molecularly imprinted BiVO<sub>4</sub> micromotors that combine simultaneous capture, photocatalyt... |
41668787 | Enhanced NH<sub>3</sub> uptake and selectivity at low pressure in monolithic MOF-808 metal-organic gels incorporating CuCl<sub>2</sub>. | The capture and separation of trace NH<sub>3</sub> from industrial processes or polluted air remains a significant challenge. Herein, we report a monolithic CuCl<sub>2</sub>@G808 metal-organic gel achieving an NH<sub>3</sub> uptake of 2.23 mmol g<sup>-1</sup> at 298 K and 0.002 bar: a 79% enhancement compared to pristi... |
41666924 | Synergistic mechanical and therapeutic modulation of engineered tumor cell-derived microparticles for enhanced cancer treatment. | Cancer stem cells (CSCs) and circulating tumor cells (CTCs) are pivotal contributors to tumor progression, metastasis, and therapeutic resistance. However, their effective eradication remains a significant hurdle in cancer treatments. Here, we report a mechanically optimized drug delivery platform based on ginsenoside ... |
41666720 | Dual-metal/ binary-linker MOF with DABCO pillaring for high-performance visible-light photocatalytic degradation of organic contaminants in model and real industrial wastewater. | Dual-linker cerium-zirconium metal-organic framework (CeZrBD) structures were synthesized using terephthalic acid (BDC) and 1,4-diazabicyclo[2.2.2]octane (DABCO) to be utilized as high-performance photocatalysts for the visible-light degradation of Malachite Green (MG) and Ibuprofen (IBP). Two structural variants, CeZr... |
41666484 | Architectural modulation of polymeric hydrogen sulfide donors: Structure-responsive materials for controlled therapeutics. | Hydrogen sulfide (H<sub>2</sub>S), once regarded merely as a malodorous and toxic gas, has emerged as a vital endogenous signaling molecule with multifaceted physiological roles, encompassing neuromodulation, vasorelaxation, cytoprotection, and the regulation of inflammatory responses. Despite this growing recognition ... |
41664462 | Hemocompatibility of Carbosilane Dendrimers as a Therapeutic siRNA Delivery System across Blood-Brain Barrier. | The development of nanocarriers offers a promising strategy for the delivery of therapeutics to the central nervous system. However, the clinical translation of nanosystems hinges on their interactions with blood components, which not only dictate their biodistribution and therapeutic efficacy but also may pose potenti... |
41664451 | High-Efficient Photocatalytic Synthesis of Tetrahydroquinolines Featuring Cu/Zr Metal-Organic Frameworks. | Tetrahydroquinolines (THQs) are essential scaffolds in natural products and pharmaceutical agents, and feasible synthetic assembly strategies for them remain highly desirable. Photocatalysis presents an ecofriendly and atom-utilizing pathway for obtaining THQs; however, the development of high-performance photocatalyst... |
41664448 | Solubility of Incongruently Melting Active Pharmaceutical Ingredient Cocrystals: The Hydrochlorothiazide-Nicotinamide System. | Pharmaceutical cocrystallization is a promising strategy to enhance the solubility and bioavailability of hydrophobic active pharmaceutical ingredients (APIs). However, when API-coformer cocrystals exhibit incongruent melting, understanding and predicting their solubility in water becomes significantly more complex. In... |
41664419 | Development of Zn/Nb-Bimetallic Organic Framework Film Optical Waveguides for the Study of Improved Optical Gas-Sensing Specificity. | Gas adsorption selectivity improvement of a metal-organic framework (MOF)-based sensor presents a significant challenge. This study addresses the enhancement of gas adsorption selectivity in MOFs by introducing bimetallic centers. The bimetallic zinc/niobium MOF (Zn/Nb-NDI-BMOF) was synthesized through the solvothermal... |
41664303 | Construction of Quinazoline-Bridged Donor-Acceptor Covalent Organic Frameworks for Photocatalytic Sulfoxide Synthesis from Alkenes and Thiols. | As an emerging class of crystalline porous materials, COFs have attracted increasing attention in fields such as photocatalysis. Understanding how the linkage chemistry of COFs influences their construction and photoelectrochemical properties and photocatalytic performance remains a significant challenge. Herein, two q... |
41664293 | Efficient Removal of Short-Chain Perfluoroalkyl Substances by Cavity-Directed Aggregation in a Molecular Cage Host. | The removal of perfluoroalkyl substances (PFAS) from water is critical to protect human health and the environment. However, removing short-chain PFAS remains a significant challenge, and a molecular-level understanding of their binding is lacking. Here, we utilise a metal-organic cage (MOC 1) as a model "pore" to eluc... |
41664265 | Harnessing Controlled Dealloying-Support Coupling for Ultrastable PtNi Catalysts in PEMFC Applications. | Platinum-transition metal (PtM) alloys are among the most promising oxygen reduction reaction (ORR) catalysts, yet their practical deployment in proton-exchange membrane fuel cells (PEMFCs) is hindered by transition-metal dissolution, particle coarsening, and insufficient durability. Moreover, conventional alloying or ... |
41664205 | Single-cell transcriptomic analysis of plant quiescent center by third-generation sequencing reveals developmental trajectories. | <h4>Background</h4>The quiescent center of plant roots plays a critical role in maintaining stemness and proliferative activity of surrounding meristem cells that drive root growth. However, it remains difficult to distinguish and isolate quiescent center cells for transcriptomic analysis.<h4>Results</h4>To overcome th... |
41664098 | A novel Ca(II) coordination polymer with 3-(3-carboxyphenyl)-isonicotinic acid: design, DFT analysis, and catalytic efficiency. | The traditional strategies to improve the catalytic performance of metal complexes mainly focus on the selection of ligands and central metal ions. Herein, a novel calcium(II) coordination polymer, abbreviated as [Ca(L)(H<sub>2</sub>O)<sub>3</sub>]<sub>n</sub>·H<sub>2</sub>O, was synthesized by assembling 3-(3-carboxyp... |
41664059 | Core-shell microneedles with MMP/pH-triggered release for periodontitis bone repair. | Periodontitis is a localized inflammatory condition triggered by periodontal pathogens and marked by uneven loss of alveolar bone. The clash between the persistent inflammatory environment and requirement for bone regeneration complicates the treatment of periodontitis. To address this issue, we developed a core-shell ... |
41663842 | Regulation of DMSP organosulfur cycling in ubiquitous Roseobacter marine bacteria. | Dimethylsulfoniopropionate (DMSP) catabolism by marine Roseobacters is important for global biogeochemical cycling and the climate. Many Roseobacters contain competing DMSP demethylation and cleavage pathways, but only cleavage produces the climate-cooling gas dimethylsulfide. Here, we identify the "switch" regulator i... |
41663520 | Molecular insights into efflux pump genes in ciprofloxacin- and methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis clinical isolates from Iraq. | Efflux pumps play a critical role in developing antimicrobial resistance (AMR) in S.aureus and S.epidermidis. Therefore, this study aimed to investigate the frequency and distribution of efflux pump resistance genes (norA, mepA, and mdeA), and potentially assess their association with antibiotic susceptibility profiles... |
41663485 | Photoinduced proton transfer in differently structured water: an EPR approach to solving a classic problem. | The mechanism of proton transfer (PT), and how it is affected by water structure, is a fundamental issue in numerous chemical and biological processes. Formulated more than 200 years ago, a possible model for PT in aqueous media was proposed by Grotthuss, which continues to be actively studied and debated. In this stud... |
41663448 | Chromosome-level genome assembly of mud snail Bullacta exarata. | The mud snail Bullacta exarata, a marine economic shellfish in China. It is a simultaneous androgynous molluscan species, and characteristic of euryhaline distribution and superior growth performance. To further reveal the genetic mechanisms related to environmental adaptation and reproductive traits of B. exarata, we ... |
41663438 | AntiPan: a genome-informed in silico pipeline for advancing subunit vaccine discovery against Staphylococcus aureus. | Staphylococcus aureus (S. aureus) remains a major global health threat due to its multidrug resistance and immune evasion mechanisms. Despite numerous vaccine trials, no licensed vaccine is currently available for human use. Existing reverse vaccinology pipelines often neglect key host-pathogen immune interactions or r... |
41663397 | MYC modulates TOP2A diffusion to promote substrate detection and activity. | Topoisomerases alleviate DNA supercoiling by cleaving and resealing DNA strands. Previously, we showed that the oncoprotein MYC recruits and stimulates topoisomerases to remove DNA entanglements generated by oncogenic transcription. Understanding this mechanism may suggest methods to inhibit MYC-driven topoisomerase ac... |
41663378 | The crucial but insufficient role of E2s domain's residues 490 and 492 in determining the host tropism of hepatitis E virus. | Hepatitis E virus (HEV) is a significant pathogen causing acute viral hepatitis globally, posing a particular threat to pregnant women. HEV infects a range of host species, with distinct genotypes exhibiting genotype-specific tropism for different host hepatocytes. The P domain of viral capsid protein plays a central r... |
41663157 | Fracture risk tools performance and potential use in systemic lupus erythematosus. | <h4>Objective</h4>Skeletal fragility is a major comorbidity in systemic lupus erythematosus (SLE), yet the accuracy of fracture risk algorithms in this population remains uncertain. We compared the discriminative ability of Fracture Risk Assessment Tool (FRAX) and the Italian FRAX-derived tool (DeFRA) for fractures in ... |
41662722 | Straightforward Dual Oxidative Cyclization Routes Enable Easy Access to Multifunctional Pyrrole-Fused Perylene Diimides. | A dual route involving oxidants under heterogeneous conditions (PbO<sub>2</sub>) or basic biphasic conditions, i.e., K<sub>3</sub>[Fe(CN)<sub>6</sub>]/KOH to C-N bond-forming pyrrole-fused PDIs is developed. These routes avoid the stringent conditions required for coupling reactions or other multistep processes used to... |
41662663 | Spatial Ion Redistribution Enables Stable Ethylene Synthesis in Acidic CO<sub>2</sub> Electrolysis. | Electrocatalytic CO<sub>2</sub> reduction (eCO<sub>2</sub>R) under acidic conditions mitigates carbon crossover and energy losses, yet selective multicarbon synthesis remains challenging due to competing hydrogen evolution. Conventional efforts manipulate the electrochemical double layer to enrich alkali cations but re... |
41662571 | Achieving Efficient Triple-Cation Perovskite Solar Cells with Fill Factor Exceeding 86% via a Uniform Interface Passivation Strategy. | Interfacial defects in triple-cation perovskite films limit device efficiency and stability, and passivation strategies often face a critical trade-off between defect coverage and charge transport. We propose a uniform interfacial passivation approach using 2-(1-cyclohexenyl)ethylammonium iodide (CHEAI) with a mixed so... |
41662528 | Decoding antibody response to MERS-CoV in wild dromedary camels. | Wild dromedary camels in the Arabian Peninsula and Africa have harbored antibodies against Middle East Respiratory Syndrome Coronavirus (MERS-CoV) for decades, predating zoonotic spillover to humans. However, the potency, specificity, and structural characteristics of these antibodies remain poorly understood. Here, we... |
41662525 | Antagonism of RNA silencing in the yellow fever mosquito, <i>Aedes aegypti</i>, by the nsP2 protein of the prototype alphavirus. | Alphaviruses establish persistent infections in mosquito vectors despite robust antiviral RNA interference (RNAi) pathways, suggesting that they employ mechanisms to counteract host immunity. We demonstrate that the nsP2 protein of Sindbis virus (SINV), the prototype alphavirus, functions as a viral suppressor of RNA s... |
41662510 | Surface Tension Isotherms: Reconceptualizing Adsorption, Self-Assembly, and Micelle Formation via the Fluctuation Theory. | Given a surface tension isotherm (i.e., how interfacial free energy changes with the surfactant concentration), can we gain insight into how surfactant molecules interact at the interface and in the bulk solution? Historically, surfactants were modeled to bind onto a uniform interface, before aggregating stoichiometric... |
41662500 | Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium. | The intricacies of neuroimmunity underscore its pivotal role in the onset and progression of neurological diseases, yet its precise modulation remains a formidable challenge. The emergence of nanogenerators offers a promising avenue to overcome these obstacles, introducing a new paradigm for regulating neural immune re... |
41662497 | A LDH-Based Supramolecular Photosensitizer-Functionalized Bioactive Glass Scaffold for Integrated Postoperative Osteosarcoma Recurrence Prevention and Bone Regeneration. | Layered double hydroxide (LDH)-based materials have been explored as efficient photosensitizers for photodynamic therapy (PDT) or functional agents for bone regeneration, holding great promise in the synergistic PDT-mediated osteosarcoma treatment and bone reconstruction. Herein, we report the functionalization of 5-io... |
41662485 | A Spatiotemporally Controlled Nanoplatform for Photothermal BRD4 Degradation Enables Synergistic Cancer Immunotherapy. | Conventional targeted protein degradation (TPD) via PROTACs is limited by E3 ligase reliance and a lack of spatiotemporal control, often causing systemic toxicity. Here, we report a photothermolysis-targeting conjugate (PTTAC) strategy for precise, light-activated degradation. We constructed a multifunctional theranost... |
41662475 | Layered ZIFs Using a Surfactant as a Structure Directing Agent. | Zeolitic imidazolate frameworks (ZIFs) are three-dimensional (3D) porous materials with only a few exceptions - ZIF-L, Zn<sub>2</sub>(benzimidazole)<sub>4</sub>, etc. Herein, we report the synthesis of a new layered ZIF, which we call ZIF-S. We use a surfactant (sodium dodecyl sulfate) as a structure-directing agent, a... |
41662438 | Legionella effector protein SidG disrupts host cytoskeleton via targeting Arp2/3 complex. | Legionella pneumophila is a facultative intracellular bacterial pathogen capable of surviving and replicating within host cells, including macrophages and protozoans. It employs the Dot/Icm type IV secretion system (T4SS) to inject over 330 effector proteins into host cells, manipulating various cellular processes to f... |
41662400 | Accessibility of the unstructured α-tubulin C-terminal tail is controlled by microtubule lattice conformation. | Microtubules are cytoskeletal filaments that self-assemble from the protein tubulin, a heterodimer of α-tubulin and β-tubulin, and are important for cell mechanics, migration, and division. Much work has focused on how the nucleotide state of β-tubulin regulates the structure and dynamics of microtubules. In contrast, ... |
41662298 | Biologically Adaptable Quantum Dots: Intracellular in Situ Synthetic Strategy and Mechanism. | ConspectusQuantum dots (QDs), a remarkable inorganic semiconductor nanocrystal capable of converting light energy into electrical, chemical, thermal, and other forms of energy, can be used to create super living systems through their fusion with cells, which hold tremendous potential for biomedical applications. Althou... |
41662297 | [Cu<sub>12</sub>L<sub>8</sub>] Coordination Cage-Based Metal-Organic Framework for Iodine Capture. | The electron-rich moieties and aromatic conjugated units are beneficial for promoting the adsorption and capture of iodine. Based on this principle, this study uses a triazine derivative poly(carboxylic acid) ligand H<sub>6</sub>TMTTA as an organic ligand and Cu<sup>2+</sup> as a metal node to construct a novel cage-ba... |
41662191 | Structure-Property-Application Correlations of Early Transition Metal Chalcogenides: A Dichalcogenide-Centered Perspective. | Early transition metal (ETM)-based chalcogenides constitute a diverse family of layered materials with tunable structural, electronic, and chemical properties. While this materials class includes dichalcogenides, sesquichalcogenides, and polychalcogenides, research efforts and technological applications have been predo... |
41661723 | On-Surface Synthesis of Isotactic Double-Stranded Corannulene Polymers Steered by Hierarchical Supramolecular Self-Assembly. | On-surface synthesis has revolutionized the construction of functional nanostructures. Thus far, however, the concept of polymer tacticity has remained unexplored in this context. Tacticity impacts polymer properties, which in turn governs polymer applications. An all-syn arrangement of substituents in isotactic polyme... |
41661684 | Modulating Fluorescent and Chiral Properties of Luminescent Self-Assemblies by Supramolecular Interactions. | In recent years, the regulation of chiral fluorescent self-assembly via dynamic and controllable supramolecular interactions has emerged as an effective strategy for the construction of intelligent luminescent materials. Herein, a luminescent chiral self-assembly system with tunable fluorescence and chiral properties w... |
41661675 | Structure and optical properties of a trimetallic cobalt-molybdenum-sodium metal-organic framework. | The crystallization of a trimetallic cobalt-molybdenum-sodium metal-organic <!?tlsb=-0.05pt>framework, poly[μ-benzene-1,3,5-tricarboxylato-tetra-μ-oxido-cobaltmolybdenumtrisodium], UOW-10 or [Na<sub>3</sub>Co(MoO<sub>4</sub>)(BTC)]<sub>n</sub>, is achieved by solvothermal synthesis using benzene-1,3,5-tricarboxylic aci... |
41661498 | Self-Assembled Monolayers in Inverted Perovskite Solar Cells: A Rising Star with Challenges. | Recently, self-assembled monolayers (SAMs) have been confirmed as a promising hole-selective contact and interfacial modifier for inverted perovskite solar cells (IPSCs), contributing to an inspiring record power conversion efficiency close to 27%, along with excellent stability. This review demonstrates the critical r... |
41661468 | Biomimetic Synapses Based on Halide Perovskites for Neuromorphic Vision Computing: Materials, Devices, and Applications. | The demand for accurate perception of the physical world has led to a dramatic increase in visual sensing data, accompanied by challenges in the energy efficiency of data processing. However, conventional vision systems with separated sensor and processing units struggle to handle increasingly intricate and large-scale... |
41661463 | Nanotherapy for acute pancreatitis: a systematic review of experimental strategies and mechanisms of action. | <h4>Background</h4>Acute pancreatitis (AP) is a severe inflammatory disease that has limited pharmacological options. Nanotechnology-based drug delivery systems have shown promise in preclinical models, but a comprehensive synthesis of their mechanisms and therapeutic profiles in AP is lacking.<h4>Objective</h4>To syst... |
41661462 | The role of deubiquitinase USP33 in colorectal cancer tumorigenesis and its potential as a therapeutic target predictor. | Deubiquitination(DUB) is a critical cellular process that regulates protein stability and functionality, playing essential roles in cell proliferation, migration, tumorigenesis, and various molecular signaling pathways. Within the DUB enzyme family, ubiquitin-specific protease 33 (USP33) is found to be aberrantly expre... |
41661421 | Smart nanoparticle delivery systems for curcumin: a targeted strategy to enhance anticancer efficacy and bioavailability. | Curcumin, a natural polyphenol derived from Curcuma longa, exhibits potent multimodal anticancer activity by modulating critical oncogenic pathways (e.g., NF-κB, STAT3, PI3K/Akt/mTOR), inducing apoptosis, suppressing angiogenesis, and reversing multidrug resistance (MDR). However, its clinical translation is severely h... |
41661388 | Fullerene C60 in dental materials: a comprehensive review of carbon nanotechnology applications and future prospects. | Teeth and dental materials are very noteworthy because of their important role in digestion and facial beauty. It is necessary to develop dental materials with suitable physical, chemical and biological properties to improve the quality and beauty of teeth. Fullerene, as a spherical allotrope of carbon, has potent prop... |
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