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41661353 | Magnetic nanoparticles as promising materials for the future of medicine. | Over the past few decades, magnetic nanoparticles (MNPs) have emerged as a focal point of research due to their versatility and diverse applications across biomedical and technological domains. The rapid advancement in nanotechnology has enabled MNPs to be utilized in drug delivery, magnetic resonance imaging (MRI), an... |
41661310 | Terminal-Directed Supramolecular Liquid Crystal Formation by Designed Coiled-Coil Interparticle Stacking. | Elucidation of the sequence-level dynamics that direct the hierarchical assembly of peptides remains a challenge. Herein, a simulation-guided experimental framework demonstrates that computationally designed, single charge-type (SC), coiled-coil peptides exhibit multiple lyotropic liquid-crystalline (LC) phases via pro... |
41661166 | Citalopram exhibits immune-dependent anti-tumor effects by modulating C5aR1<sup>+</sup> TAMs. | Administration of selective serotonin reuptake inhibitors (SSRIs) is associated with a reduced cancer risk and shows significant anti-tumor effects across multiple tumor types, suggesting the potential for repurposing SSRIs in cancer therapy. Nonetheless, the specific molecular target and mechanism of action of SSRIs r... |
41661129 | Identification of novel pyrazolo[4,3-c]pyridine and diazepane derivatives as potent inhibitors of <i>Mycobacterium tuberculosis</i> protein tyrosine phosphatase B. | Tuberculosis (TB), caused by <i>Mycobacterium tuberculosis</i> (<i>M.tb</i>), continues to pose a critical global health threat as a leading infectious cause of mortality. Therapeutic efficacy is increasingly compromised by the emergence of multidrug-resistant strains and the limitations of existing regimens, which nec... |
41661067 | A Lead(II)-Based Coordination Polymer Exhibiting Photocatalytic and Electrochemical CO<sub>2</sub> Reduction Activities. | Mixed-anion compounds incorporating multiple anionic species within a single crystal lattice can exhibit novel structural and functional properties and so have recently attracted much attention. These materials offer unique coordination environments that can lead to emergent behaviors relevant to various applications. ... |
41661070 | Fe<sup>2+</sup>/Fe<sup>3+</sup> Redox Modulation in Iron-Based Metal-Organic Frameworks for Efficient C-N Coupling in Electrocatalytic Urea Synthesis. | Designing efficient catalysts for the electrocatalytic coreduction of CO<sub>2</sub> and N<sub>2</sub> into urea remains challenging due to the sluggish activation of both molecules and the complex C-N coupling process. Herein, we report an iron-based metal-organic framework (Fe-MOF) system in which the ratio of Fe<sup... |
41661071 | Synthesis, Mechanism Analysis, and Degradation Pathways of Fe-Based Metal-Organic Frameworks/BiOBr Heterojunctions for Effective Photocatalytic Organic Pollutant Degradation. | Conventional photocatalysts suffer from rapid electron-hole recombination, severely limiting their practical application in wastewater treatment. Moreover, many organic degradation systems require the addition of hydrogen peroxide or persulfate to enhance photocatalytic activity, but this not only often leads to second... |
41661055 | An Asymmetric Stem-Loop Translator Enhances Specificity of One-Pot Isothermal CRISPR/Cas12a Assay. | Sensitive and specific detection of molecular biomarkers is fundamental to clinical diagnostics and biomedical research, yet existing CRISPR-based assays often suffer from nonspecific activation and cross-reactivity. Here, we introduce an asymmetric stem-loop translator that markedly enhances the specificity of a one-p... |
41660999 | <i>N</i>-Terminal Octylated Peptoid Hydrogels as 3D-Printable Cell Scaffolds and Proteolytically Robust Cargo Depots. | Supramolecular hydrogels that mimic the extracellular matrix (ECM) represent promising materials for tissue engineering and drug delivery. However, conventional hydrogels formed via the self-assembly of natural or synthetic building blocks often face a trade-off between biological functionality and biochemical stabilit... |
41660966 | Phosphate-Mediated Cl<sup>-</sup> Repulsion and B<sub>2</sub>O<sub>3</sub>-Assisted Hydroxylation Synergize Ionic Interface Stability in Seawater Splitting. | Ionically bonded interfaces are crucial for achieving selective and stable direct seawater electrolysis, yet their vulnerability under corrosive and high-current conditions limits long-term performance. Here, we report a two-dimensional Fe-MOF@PW<sub>8</sub>O<sub>26</sub>.B<sub>2</sub>O<sub>3</sub> heterostructured ele... |
41660852 | Chain Versus Ring: Characterization of a Meta-Phenylene Ladder Polymer and Its Octameric Macrocycle. | A methyl-substituted ladder meta-phenylene macrocycle (MeLMMP) and its corresponding ladder polymer (MeLPMP), a meta-analogue of the well-known ladder-type poly(para-phenylene), LPPP, were synthesized and comprehensively investigated. Both compounds exhibit limited conjugation due to the meta-linked phenylene units, re... |
41660838 | Mouse models of tuberculosis uniformly featuring hypoxic necrotic lesions and poor response to chemotherapy. | Mouse models have been key to studies of tuberculosis pathogenesis and drug efficacy, but many, such as those employing BALB/c mice, fail to reproduce the full range of heterogenous microniches observed in well-structured human lesions, which feature hypoxic caseous cores of necrotic debris surrounded by infected foamy... |
41660846 | Biochemical and structural analyses of metallo-β-lactamase VIM-28: impact of substitutions at residues 224 and 228 on substrate profile, stability, and zinc affinity. | Metallo-β-lactamases (MBLs) hydrolyze a broad range of β-lactams, including carbapenems. VIM-28, an MBL identified in <i>Pseudomonas aeruginosa</i>, is an H224L/S228R variant of VIM-1 and H224L variant of VIM-4. Compared with VIM-26 (R228S), VIM-28 displayed decreased <i>K</i><sub>m</sub> (12.5 for VIM-28 vs 513 μM for... |
41660828 | The <i>Helicobacter pylori</i> TlpD cytoplasmic chemoreceptor requires an intact C-terminus for polar localization and function. | Bacteria localize proteins to distinct subcellular locations, including chemoreceptors, which frequently localize to the bacterial pole. Although some polarity-promoting mechanisms have been described, many chemoreceptors lack clear routes to becoming polar. TlpD of the bacterial pathogen <i>Helicobacter pylori</i> is ... |
41660799 | Divergence in Cu(II)- and Zn(II)-Based Coordination Polymers: The Sensing of Melatonin and Tryptophan, and Their Anticancer Activity. | Accurate and selective recognition of ions and molecules is crucial in medical and diagnostic research. Cu(II)- and Zn(II)-based coordination polymers (CPs) have been designed in this work to detect trace levels of melatonin and tryptophan and evaluate their anticancer activity. The [Cu<sub>2</sub>(4-bph)<sub>2</sub>(a... |
41660794 | Coaggregation Strengthened Nanozymes for the Identification of Oral Cariogenic Bacteria. | Dental caries, caused by oral cariogenic bacteria, underscore the critical importance of early diagnosis for effective prevention and treatment. The identification of oral cariogenic bacteria depends on the development of the recognition elements. In this work, coaggregation between bacteria has been subtly mined for e... |
41660789 | pH- and Solvent-Stable Zn<sup>II</sup>/Cd<sup>II</sup> Metal-Organic Frameworks with 2,1,3-Benzothiadiazole Derivative for Turn-On Fluorescence Sensing Dipicolinic Acid and Thiamine in Living Cells. | The rapid detection of specific biological substances and biomarkers has the potential to contribute to the early identification, diagnosis, and prevention of diseases. Two examples of structurally similar luminescent metal-organic frameworks based on the same mixed ligands, namely {[M(BTBD)<sub>2</sub>(bptc)<sub>0.5</... |
41660758 | Uncovering a previously unknown function of polyphosphate in polyadenylated RNA-induced amyloidogenesis of Hfq. | Polyphosphate (polyP), a ubiquitous and highly conserved biopolymer, has emerged as a potential modulator of bacterial amyloidogenesis. In bacteria, polyP contributes to the formation of dense intracellular regions associated with transcriptional silencing. Gene regulation and chromatin organization are primarily contr... |
41657302 | Rapid Magnetic Separation Absorbent Integrating Amidoxime Chelators and Antibiofouling MOF Coatings for Efficient Uranium Extraction. | Developing adsorbents that couple high uranium affinity with durability in complex environments remains a pivotal challenge for efficient uranium harvesting. Here, we report a hierarchically engineered magnetic composite, Fe<sub>3</sub>O<sub>4</sub>@PAO@MPN-Met, that integrates (i) a superparamagnetic Fe<sub>3</sub>O<s... |
41657284 | Conformation-Modulated Lignin for Durable and High-Output Cellulosic Triboelectric Materials Toward Self-Powered Sensing. | Cellulose-based triboelectric sensors offer a sustainable pathway toward self-powered electronics, yet their practical reliability is severely constrained by long-term tribo-induced fiber fibrillation and the resulting interfacial degradation. Herein, we report a conformation-engineered alkali lignin (EAL) that enables... |
41657053 | Sustainable CO<sub>2</sub> Capture Using Porous CuBDC Monoliths via Pickering Foam Templating Reinforced with Bacterial Cellulose. | Metal-organic frameworks (MOFs) offer high porosity and tunable chemistry, while practical applications are often hindered by their poor processability, low packing density, and inadequate mechanical stability when used in powder form. Shaping MOFs into monoliths could dramatically solve these limitations. However, tra... |
41657036 | Host-Guest Doping Room-Temperature Phosphorescence Sensing Strategy for the Detection of Related Substances in Naproxen APls and in the Production of Dosage Forms. | The detection of related substances in both active pharmaceutical ingredients (APIs) and dosage forms, especially via process analytical technology (PAT), is of crucial importance for the assurance of pharmaceutical quality and clinical safety. However, this process remains a formidable challenge because related substa... |
41656251 | Nanotechnology for reproductive healthcare: a comprehensive review. | The advancement of nanotechnology has revolutionized reproductive healthcare worldwide. It has enabled the treatment of various conditions, such as infertility, endometriosis, ectopic pregnancies, erectile dysfunction, sexually transmitted infections (STIs), and reproductive tissue cancers. Nanotechnology offers improv... |
41656236 | Piezoelectric scaffold with enhanced effect drives the healing of osteochondral defects through electromechanical-immune coupling. | Silk fibroin scaffolds (SFCs) that exploit piezoelectricity for osteochondral repair have been hampered by both insufficient electromechanical output and a pro‑inflammatory joint microenvironment that erodes therapeutic efficacy. To overcome these barriers, we developed an intra‑articular implantable scaffold with enha... |
41649349 | LeuO fine-tunes the virulence attributable to <i>Salmonella</i> pathogenicity island-2 via repressing <i>ssrA</i> transcription in <i>Salmonella</i> Typhimurium. | LeuO, initially identified as a leucine regulator in <i>Escherichia coli</i>, has since been identified as a global regulator required for bacterial pathogenicity in a broad range of bacteria, including <i>Salmonella</i>, <i>Shigella</i>, and <i>Vibrio</i>. This study aimed to determine the regulatory role of LeuO in <... |
41496653 | Metal-organic framework-based gas sensors: fabrication, mechanisms, and applications. | Gas-sensing technologies facilitate the early detection and prediction of unforeseen future events by tracking surrounding invisible and instantaneous molecular information, which is critical for applications in agriculture, medicine, chemical process control, and environmental monitoring. Recent advancements in metal-... |
41481151 | Halogen bonding in functional chiral systems. | The halogen bond (XB) is a directional noncovalent interaction formed between a halogen atom acting as an electrophilic site and a Lewis base. In recent years, it has shown great potential in the design of functional chiral systems. Due to its tunable interaction strength and pronounced directionality, the XB is becomi... |
41257418 | Metal-organic frameworks and derivatives as next-generation materials for electrochemical energy storage. | The global pursuit of carbon neutrality demands transformative clean energy solutions, with advanced energy storage materials at the forefront. Metal-organic frameworks (MOFs), owing to their tunable porosity, ultrahigh surface areas, and adaptable physicochemical properties, have rapidly risen as promising building bl... |
41178495 | Site-selective thionation and doping enabled tunable full-color emission in nonconventional luminophores. | Nonconventional luminophores have gained significant attention for their distinctive luminescence behaviors and promising applications. However, achieving precise control over their photoluminescence (PL) remains a substantial challenge. Current strategies for structural modification remain largely semi-empirical, lack... |
41908932 | Chinese Herbal Medicine in Ulcerative Colitis-Associated Carcinogenesis Treatment: Mechanisms, Progress, and Future Directions. | Colitis-associated colorectal cancer (CAC) is a highly prevalent malignancy of the digestive tract. The close association between ulcerative colitis (UC) and CAC makes inhibiting this carcinogenic transformation a critical preventive goal. Based on traditional Chinese medicine (TCM) theories of "dampness-heat stasis" a... |
41768748 | Poly(Ionic Liquid)s Dispersants for Lubricants: A Review on Structure-Property Relationships. | Poly-(ionic liquid)-s (PILs) have emerged as a versatile class of materials whose structural diversity, ranging from backbone chemistry and side-chain functionality to counterion type, governs their aggregation behavior, interfacial adsorption, and nanoscale self-assembly. These attributes make PILs attractive candidat... |
41751791 | Enhancing Cancer Therapy with Hyperthermia: Synergistic Effects with Natural Compounds and Conventional Treatments. | Hyperthermia (HT) is a promising adjunct to conventional cancer therapies such as chemotherapy and radiotherapy (RT). It offers several advantages, including low toxicity to normal tissues, limited tumor resistance, and synergistic therapeutic effects. HT enhances treatment efficacy by inhibiting DNA repair mechanisms,... |
41750804 | Effects of Phenolic Acids with Different Structures and Lauric Acid on the Digestive Properties and Physicochemical Characteristics of Breadfruit Starch. | This study examined how complexes formed between breadfruit starch, lauric acid (LA), and phenolic acids (gallic/GA, 3,4-dihydroxyphenylacetic/DOPAC, caffeic/CA) affect starch digestibility and properties. All complexes increased resistant starch (RS) content from 47.19% (native) to 49.12-70.14%, with the caffeic acid-... |
41750803 | Effects of Different Fixation Methods on Color, Aroma, and Chemical Composition of <i>Lonicerae japonicae</i> Flos Tea. | <i>Lonicerae japonicae</i> flos (LJF) is a natural product with medicinal, edible, and ornamental value which has been developed into LJF tea. At present, LJF tea can be processed using four main fixation methods: fixation by sun drying (SG), hot-air oven drying (HG), stir-frying drying (CZ), and steaming (ZZ). However... |
41745262 | Detection of <i>Metschnikowia bicuspidata</i> in Chinese Mitten Crabs (<i>Eriocheir sinensis</i>) Using Recombinase Polymerase Amplification. | The fungal pathogen <i>Metschnikowia bicuspidata</i> causes "milky disease" in the Chinese mitten crab (<i>Eriocheir sinensis</i>), which poses substantial challenges to sustainable aquaculture development considering the current lack of effective treatment interventions. To address this issue, in laboratory validation... |
41745024 | Toward Skin-like Sensors: Stretchable Conductive Gels for Triboelectric Applications. | With the rapid development of artificial intelligence and wearable electronics, there is an increasing demand for skin-like, flexible, and self-powered sensors capable of continuously perceiving mechanical stimuli and human motions. Triboelectric nanogenerator (TENG)-based sensors incorporating stretchable conductive g... |
41744728 | A Review of Aggregation-Based Colorimetric and SERS Sensing of Metal Ions Utilizing Au/Ag Nanoparticles. | The accurate monitoring and dynamic analysis of metal ions are of considerable practical significance in environmental toxicology and life sciences. Colorimetric analysis and surface-enhanced Raman scattering (SERS) sensing technologies, utilizing the aggregation effect of gold and silver nanoparticles (Au/Ag NPs), hav... |
41732514 | Enhanced curing of low-sodium duck meat: a comparison of sequential <i>versus</i> collaborative ultrasound-assisted brining. | High sodium content in traditionally cured duck meat poses health concerns, yet reducing salt compromises its quality and efficiency. This study compared sequential (SU, ultrasound before brining) and collaborative (CU, ultrasound during brining) ultrasonication (0-500 W) for low-sodium (6% NaCl) duck meat curing, with... |
41717368 | From self-assembly to controlled release: synthesis and properties of dynamic imine-based Gemini surfactants for curcumin delivery. | Surfactants based on dynamic covalent bonds have attracted great interest in the past few decades due to the coexistence of covalent and non-covalent bonds. As a novel structure of surfactants, Gemini surfactants exhibit excellent surface activity and aggregation behavior. This work synthesized dicot quaternary ammoniu... |
41690168 | Ultrasonic driven resveratrol induced egg-derived amyloid-like fibrils hydrocolloids for stabilizing aqueous cyanidin-3-O-glucoside. | This study investigated a low-frequency ultrasound-driven, resveratrol-induced hydrocolloid composed of ovalbumin and lysozyme amyloid-like fibrils for the efficient stabilization of aqueous cyanidin-3-O-glucoside. Results demonstrated that resveratrol, under ultrasonic treatment, acted as a molecular bridge, disruptin... |
41679210 | MOF-based nanozyme incorporated composite film with prominent antibacterial activity and multiple functionalities for fruit preservation. | The food packaging films with tunable multiple functionalities like sustained antibacterial activity, good light blocking and suitable water vapor permeability present significant practical implications for food preservation. Herein, metal-organic framework (MOF) based nanozyme with oxidase-like activity was constructe... |
41679161 | Wood-derived cellulose aerogel decorated with high Zr-MOF loading for simple and efficient extraction of etomidate analogs from urine and e-cigarette samples. | Etomidate and its analogs can produce euphoria and addiction, and their recent abuse has led to an increasing number of poisoning and fatal cases. Thus, they are classified as controlled psychotropic drugs. This work proposed small-sized wood aerogel-supported zirconium metal-organic framework (UiO-66) particles for th... |
41666583 | Reliable ratiometric electrochemical sensor for methyl parathion detection in vegetables based on nile blue A-functionalized Ce-MOF/carbon nanohorns composite. | An efficient ratiometric electrochemical sensor on basis of nile blue A-functionalized cerium-based metal-organic framework/carbon nanohorns composite (Ce-MOF/CNHs@NBA) was developed for reliable determination of residual methyl parathion (MP). Ce-MOF/CNHs@NBA composite was synthesized via a green and mild room-tempera... |
41664707 | Oligodendrocyte: Development, Plasticity, Biological Functions, Diseases, and Therapeutic Targets. | In the past few years, the incidence rate of central nervous system (CNS) diseases is still growing. Meanwhile, the molecular mechanism on the pathogenesis of neurological diseases remains elusive. Oligodendrocyte progenitor cells (OPCs) are distributed in the whole CNS and represent a population of migrating and proli... |
41664706 | Accelerate the Highly Efficient Development of mRNA Vaccines Through Advanced Computational Methods. | mRNA medicine is an emerging therapeutic approach that utilizes messenger RNA to synthesize functional proteins directly within target cells. This technology offers notable advantages including rapid development cycles, diverse therapeutic applications, and adaptable platform design for various diseases. However, mRNA ... |
41664705 | State-of-the-Art Strategies for Circular RNA in Cancers: Opportunity and Challenge. | Circular RNAs (circRNAs) are characterized by their covalently closed structure, remarkable stability, and precise spatiotemporal regulation, evolving from once-overlooked transcriptional byproducts to pivotal molecular regulators. In addition to their well-established function as microRNA sponges, circRNAs serve as pr... |
41656977 | Comparative Study on the Effect of La<sub>2</sub>O<sub>3</sub>, CeO<sub>2</sub>, Nd<sub>2</sub>O<sub>3</sub>, and Sm<sub>2</sub>O<sub>3</sub> on Ni-SiO<sub>2</sub> for Dry Reforming of Methane. | Four lanthanide-oxide-modified Ni-SiO<sub>2</sub> catalysts were prepared via the β-cyclodextrin-assisted impregnation method and were comparatively evaluated for dry reforming of methane (DRM) under the severe conditions of 750 °C, CH<sub>4</sub>/CO<sub>2</sub> molar ratio of 1, and GHSV of 84 000 mL g<sup>-1</sup> h<... |
41656954 | Effect of Shape on Cellular Uptake of Visible-Light- and Redox-Responsive Biodegradable Linear-Dendritic Block Copolymer Micelles. | Linear-dendritic block copolymers comprising poly(ε-caprolactone) attached to hydrophilic 2,2-bis(hydroxymethyl)propionic acid (bis-MPA) ester dendron via a disulfide and containing a defined number of pendent visible-light-responsive donor-acceptor Stenhouse adduct (DASA) groups are synthesized using click chemistry a... |
41656928 | Supramolecular Nanoconfinement-Accelerated Synthesis of Two-Dimensional Styrenic Polymers Boosting Proton Conductivity in Nafion-doped Membranes. | Two-dimensional (2D) covalent polymers offer environmental stability, surface area, and mechanical resilience, but preparation of functional, freestanding 2D polymers remains challenging. Inspired by phospholipid bilayers, we developed a bilayer self-assembly strategy for 2D covalent polymer synthesis with tailored fun... |
41656910 | Fluorinated Glycan Frameshifts: Automated Synthesis Expedites the Study of Glycan-Protein Interactions by <sup>19</sup>F-BioNMR. | Given the prominence of <sup>19</sup>F-bioNMR in structural research, fluorinated glycan frameshifts hold enormous potential in studying carbohydrate-protein interactions. To contribute to this field, the synthesis of selectively C-2 fluorinated glycans related to the O3b antigen of Klebsiella pneumoniae is disclosed, ... |
41656860 | Bio-Inspired Smart Elastin-Like Polypeptides (ELPs) for Precision Drug Delivery: Molecular Strategies, Thermal Responsiveness, and Translational Advances. | Elastin-like polypeptides (ELPs), inspired by the natural elasticity of human elastin, are rapidly evolving as next-generation platforms for precision drug delivery. Their unique thermoresponsive behavior, genetic tunability, and biocompatibility position them at the intersection of molecular engineering and translatio... |
41656884 | Distance-Dependent Energy Transfer Between Organic Fluorophores and Single-Walled Carbon Nanotubes. | Single-walled carbon nanotubes (SWCNTs) are promising optical biosensing platforms due to their intrinsic near-infrared fluorescence and environmental sensitivity. While DNA-SWCNT hybrids have been widely studied, the structural arrangement of double-stranded DNA (dsDNA) on SWCNTs and its impact on exciton-fluorophore ... |
41656795 | Hydrogen-Bond Network-Directed Controllable Assembly of Stable Cyanine J-Aggregates for Long-Term and High-Contrast In Vivo Imaging. | Optical probes based on near-infrared region (NIR) small-molecule dyes have emerged as an indispensable tool for contemporary in vivo biomedical research. Nevertheless, the majority of the reported NIR small-molecule probes are plagued by issues such as poor stability, short excitation wavelength, and inadequate lesion... |
41656760 | Near-Infrared Photothermal Polymerization of Thioctic Acid Triggered by Polyoxometalate Crosslinker. | The monomer conversion rate of thioctic acid (TA) and the cross-linking degree of polymer chains significantly influence the performance of materials, making them important research topics. Herein, by selecting a reduced polyoxometalate complex modified with 1-allylpyridinium cations, which exhibits strong near-infrare... |
41656767 | Mechanistic insights into Orai dynamics during pore opening. | Orai channels form highly Ca<sup>2+</sup>-selective pores in the plasma membrane (PM) and represent one of the two essential components of the Ca<sup>2+</sup> release-activated Ca<sup>2+</sup> (CRAC) channel. The second component is the Stromal Interaction Molecule (STIM) proteins, which is located in the endoplasmic r... |
41656751 | Hydrogels with Dynamically Tunable Friction Engineered through Regrafting Polymer Brushes. | The control of friction in soft materials is critically important for applications such as soft robotics. This work presents a supramolecular hydrogel designed with reforming polymer brushes to achieve dynamically tunable friction. The hydrogel network, based on PAM-<i>co</i>-PAA and integrated with β-cyclodextrin, all... |
41656729 | Unraveling the Mechanism of a Co(-I)-Ga Photoreductant in the Catalytic Hydrodefluorination of Electron-Rich Fluoroarenes. | Strong photoreductants based on first-row transition metals are rare. We report an anionic heterobimetallic Co(-I)-Ga complex, [(H<sub>2</sub>)CoGa(N(<i>o</i>-(NCH<sub>2</sub>P<sup><i>i</i></sup>Pr<sub>2</sub>)C<sub>6</sub>H<sub>4</sub>)<sub>3</sub>)]<sup>-</sup> (<b>[2-H</b><sub><b>2</b></sub><b>]</b><sup><b>-</b></su... |
41656667 | Making Metal-Organic Cages Respond to Light for Efficient Adsorptive Separation. | Adsorptive separation, widely used in chemical and other industries, demands the regulation of adsorption capacity via temperature or pressure swings. However, energy consumption in temperature and pressure swings is high, and it is extremely desirable to develop approaches that go beyond traditional methods of modulat... |
41656669 | Rational Design of NIR-Responsive, Disulfide-Modified Bio-MOF with Antibacterial and Osteogenic Activity. | Postoperative infection remains a significant challenge in surgery, often hindering healing. This study aims to design a near-infrared (NIR)-responsive, disulfide-functionalized bioactive metal-organic framework (Bio-Zn@S-MOF) made of zinc cations, adenine, and 3,3'-dithiodipropionic acid (DTPA) ligands. The incorporat... |
41656616 | Mechanism of Engineered Rhizobia Overexpressing Cytokinin Improve Heat Stress Response in Alfalfa. | Heat stress is a major abiotic stress that limits alfalfa (Medicago sativa L.) productivity. To test whether cytokinin-overexpressing engineered rhizobia could enhance heat tolerance, we inoculated alfalfa with modified rhizobia and evaluated their physiological and molecular responses. We found that inoculation with e... |
41656586 | Integrated Chiral Recognition and Enantiomeric Separation of Histidine by Metal-Organic Frameworks Engineered with Chiral Linkers. | Despite its critical importance in disease diagnosis and drug safety, the development of methods for highly sensitive and enantioselective recognition of histidine enantiomers in complex biological media remains a formidable challenge. Here, the Chiral Metal-Organic Frameworks (CMOFs) called MOF-TH-Fe have been develop... |
41656309 | Graphene oxide/metal-organic framework composite as an effective catalyst for esterification reactions. | Herein, we report the synthesis and characterization of graphene oxide (GO) impregnated into a Zr-based metal-organic framework (MOF-801), denoted as MOF-801@GO, as a catalyst for esterification reactions. The synthesized catalyst was thoroughly characterized using various techniques, including Fourier-transform infrar... |
41656235 | A novel nanotherapeutic strategy: rescuing nucleus pulposus cells from fatty acid metabolic disorder and pyroptosis through ACOT13 by Chinese herbal formula nanoparticles. | Low back pain (LBP) is a widespread global health concern that profoundly impairs patients' quality of life and productivity. Intervertebral disc degeneration (IVDD) is considered a major pathological factor in low back pain, yet the underlying mechanisms of IVDD remain incompletely understood. Current treatment strate... |
41656243 | Zinc peroxide-copper bimetallic nanozyme with self-activated ROS and cuproptosis for superficial antifungal therapy. | Fungal infections, particularly intractable cases such as fungal keratitis (FK) and skin wound infections, remain a pressing global health challenge, further exacerbated by rising antifungal resistance and treatment-associated cytotoxicity. Herein, we report a highly effective, non-antibiotic therapeutic strategy integ... |
41656196 | Protein corona proteomics characterizes low-abundance plasma protein signatures and highlights ferroptosis-associated signals in uremic hemodialysis patients. | Patients with uremia undergoing long-term hemodialysis are prone to multi-organ complications, but the underlying molecular mechanisms remain unclear. Ferroptosis, an iron-dependent form of cell death, has been linked to inflammation and organ damage. Its role in hemodialysis-related pathology, however, has not been we... |
41655257 | Metal-Supramolecular Drug Delivery System Empowered Meningeal Lymphatic Vessels-Bridged Intracranial-Peripheral Dual Immune Modulation for Reversing Glioblastoma Immune Suppression. | Glioblastoma (GBM) presents significant challenges in treatment due to the presence of the blood-brain barrier (BBB) and immunosuppressive tumor microenvironment (TME). Here, we developed a novel metal-supramolecular delivery system (FLM@VC) that empowers meningeal lymphatic vessels (MLVs)-bridged intracranial-peripher... |
41655246 | Gate Enhancing Charge-Spin Conversion in Organic Chiral Field Effect Transistors. | Organic ferroelectric field-effect transistors (OFeFETs) are promising candidates for next-generation wearable electronics and non-volatile memory technologies owing to their bistable switching, low power consumption, and mechanical flexibility. Here, room-temperature organic chiral multiferroic FETs are demonstrated, ... |
41655249 | EDTA-Functionalized Nanoscale Metal-Organic Framework for Onco-Cardiology via Radiochemotherapy Synergy and Spatiotemporally Matched Iron Chelation. | Doxorubicin (DOX)-induced cardiotoxicity (DIC) has become a major obstacle for clinical application. While ferroptosis represents a critical therapeutic target for DIC, current intervention strategies are limited by spatiotemporal mismatches between DOX accumulation and iron chelation. Here, we engineered an EDTA-funct... |
41655260 | Non-Noble-Metal POM@MOF for Enhancing the Visible Photoinduced Baeyer-Villiger Oxidation Reactions. | Developing highly efficient, environmentally friendly, inexpensive, and readily available photocatalysts for Baeyer-Villiger (B-V) oxidation reactions is of significant importance. This study involved encapsulating Keggin-type H<sub>3</sub>PMo<sub>12</sub>O<sub>40</sub> and H<sub>4</sub>SiW<sub>12</sub>O<sub>40</sub> w... |
41655244 | Trace Alloying Unleashed: AuPt Nanoalloys Strategy Preserves Plasmonic Properties on Au Nanobipyramids While Boosting Electron Transfer for Visible Light Ammonia Synthesis. | Photocatalysis, leveraging the redox capabilities of photocatalysts under light irradiation, emerges as a promising approach for clean energy conversion and pollution control. In this study, we engineered Au nanobipyramids (Au NBPs) with trace amounts of AuPt alloy to enhance their photocatalytic efficiency for selecti... |
41655222 | OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17-Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC. | While cisplatin is a widely used and effective chemotherapeutic agent in the treatment of head and neck squamous cell carcinoma (HNSCC), the molecular mechanisms underlying its resistance remain poorly understood. In this study, we identify OCIA domain containing 2 (OCIAD2) as a central mediator of chemoresistance and ... |
41654863 | Ubiquitin-centered post-translational modification crosstalk orchestrates tumor immunity and immunotherapy response. | Remarkable progress has been made in cancer immunotherapy in recent years; however, it still faces challenges such as limited response rates, resistance, and immune-related adverse events. Ubiquitination, a key post-translational modification (PTM) of proteins, is indispensable for regulating various tumor immunity-rel... |
41566700 | Molecular engineering of lysosome-based degraders unveils a rapidly expanding therapeutic strategy. | The targeted degradation of oncogenic or misfolded proteins has emerged as a promising therapeutic strategy. While proteolysis-targeting chimeras (PROTACs) and related technologies have successfully hijacked the ubiquitin-proteasome system to eliminate disease-driving proteins, recent advances highlight the lysosome as... |
41908944 | Sugammadex and Postoperative Respiratory Failure in Head and Neck Surgery: A Cohort Study. | <h4>Purpose</h4>This study investigated whether sugammadex use reduces postoperative acute respiratory failure compared with neostigmine use in patients undergoing head and neck free flap reconstruction, a population at high risk for pulmonary complications.<h4>Patients and methods</h4>We conducted a retrospective coho... |
41907370 | Therapeutic Nanozymes in Rheumatoid Arthritis Treatment Through Disease Stage-Oriented Strategies. | Rheumatoid arthritis (RA) progresses through distinct pathophysiological states, transitioning from acute inflammatory phases with largely reversible tissue damage to chronic destructive stages characterized by irreversible structural alterations. Current therapeutic approaches largely employ uniform interventions with... |
41907367 | Nanotherapeutic Interventions for Parkinson's Disease: Modulating Pathogenic Mechanisms and Overcoming Therapeutic Obstacles. | Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder globally. Despite significant research, effective clinical treatments for PD remain limited due to its complex pathogenesis and the selective nature of PD-related lesions. Advances in nanotechnology, however, have opened new avenues for PD... |
41890653 | Recent Advances in Nanodelivery Systems Based on Extracellular and Intracellular Reprogramming Strategies for Enhanced Therapy of Atherosclerosis. | Atherosclerosis (AS) represents a chronic immunoinflammatory disorder characterized by lipid metabolism dysregulation, predominantly affecting medium and large arteries. During the initial phase of the disease, endothelial cells (ECs) undergo mesenchymal transformation, subsequently releasing various adhesion molecules... |
41794493 | Green solvents as sustainable tools for the integral valorization of peach palm (Bactris gasipaes): Bioactive composition, antioxidant potential, simulation of in vitro gastrointestinal digestion, and microbiological inhibition. | The peach palm (Bactris gasipaes) is an Amazonian species with high nutritional and functional potential, whose fractions (peel, pulp, and seeds) remain underexplored in terms of full utilization. This study investigated the bioactive composition of these fractions and assessed the application of emerging green solvent... |
41783789 | Rabies lyssavirus phosphoprotein possesses RNA duplex-unwinding activities. | Rabies lyssavirus (RABV) is a prototypical neurotropic virus that belongs to the Rhabdoviridae family and causes one of the most lethal zoonotic diseases. For RNA viruses, RNA-unwinding proteins such as helicases and RNA chaperones are crucial for the replication and/or correct folding of viral RNAs. Although numerous ... |
41768703 | Selective Reversal of Cu-Amyloid Aggregation Monitored in Real Time by Fluorescence Anisotropy: Ni-Bme-Dach vs EDTA Benchmarks. | Metal dyshomeostasis, particularly involving Cu<sup>2+</sup>, is increasingly recognized as a key contributor to amyloid-β (Aβ) aggregation and neurotoxicity in Alzheimer's disease, motivating the development of chelators capable of selectively disrupting pathogenic metal-Aβ interactions without perturbing essential bi... |
41756735 | Effects of microbial organic fertilizer on nitrogen cycling-related microbial communities and nitrogen-fixing system stability in saline soil. | Microbial organic fertilizers (MOFs) have shown to improve nitrogen fixation efficiency, particularly under saline or nutrient-stressed conditions. However, the mechanisms by which MOF influence nitrogen-cycling microorganisms and ammonia (NH<sub>3</sub>) volatilization in saline-alkali soils are still unclear. This 2-... |
41752360 | Efficient Production of γ-CD from Starch by γ-CGTase Heterologously Produced in <i>Pichia pastoris</i>, Assisted by β-CGTase Liquefaction and Pullulanase Debranching. | Cyclodextrins (CDs) are cyclic oligosaccharides composed of α(1 → 4) linked glucose units, which are widely used as solubilizers and stabilizers in the food, pharmaceutical and cosmetic industries. Among the CDs, γ-CD has attracted much attention due to its larger hydrophobic cavity and higher solubility. However, the ... |
41752359 | Microextraction Technologies as Exposomic Sensors for On-Site Environmental Air Monitoring of Volatile Organic Compounds: A Review of Commercially Available Technologies. | Microextraction Technologies (METs) have emerged as pivotal exposomic sensors for the on-site monitoring of Volatile Organic Compounds (VOCs) in ambient air. By integrating sampling and sample preparation into a single step, METs provide solvent-free, miniaturized, and field-deployable solutions that align with the pri... |
41752361 | A 5-Br-1-Propylisatin Derivative as a Promising BRD9 Ligand: Insights from Computational and STD NMR Investigation. | Bromodomain-containing protein 9 (BRD9) belongs to the non-canonical BAF chromatin remodeling complex and represents a relevant therapeutic target in pathologies featuring dysregulated epigenetic control. The absence of clinically validated inhibitors and the need for diversified chemical entities highlight the interes... |
41750800 | Tailored UV-A Irradiation and Callus Selection Enable Distinct Flavonoid Profile Production in Grape Cell Cultures. | Plant cell culture represents a sustainable platform for the production of high-value natural products. Although ultraviolet A (UV-A) radiation is established as an inducer of phenylpropanoid metabolism, its precise regulatory role in downstream flavonoid biosynthesis within grape cells remains unclear. Using red and w... |
41744727 | Development of Advanced Nanobiosensors and a Portable Monitoring System for Pesticide Detection at the Point of Need. | This work presents the development of an automated and portable monitoring system for the point-of-need detection of tebuconazole and lambda-cyhalothrin. The system features nanoparticle/aptamer-modified electrochemical sensors that are integrated into a microfluidic chip based on polydimethylsiloxane (PDMS). More spec... |
41732381 | Boosting cancer therapy with self-assembled inorganic nanocarriers via host-guest chemistry. | Inorganic nanocarriers (INCs) have been widely used in drug delivery systems due to their excellent biocompatibility, ease of synthesis and functionalization, cost-effectiveness, and robust physicochemical stability. However, small-sized INCs are prone to rapid in vivo clearance, resulting in low accumulation and limit... |
41730599 | Dendritic mixed-mode stationary phases prepared by thiol-epoxy click reaction for the determination of bisphenols in a variety of complex samples. | <h4>Background</h4>Bisphenols are widely used in thermal paper, inks, coatings, and other fields. Among them, abnormal concentrations of bisphenol A (BPA) can disrupt the human endocrine system, making it essential to closely monitor BPA levels in environmental and daily life samples. Owing to its strong separation and... |
41717365 | Construction and characterization of food-grade pickering high internal phase emulsions co-stabilized by β-cyclodextrin and konjac gum. | This study developed novel Pickering high internal phase emulsions (HIPEs) using a β-cyclodextrin (β-CD) and konjac gum (KGM) complex as an emulsifier. The effects of oil phase volume fraction (<i>ϕ</i>), complex concentration (<i>c</i>), and β-CD/KGM mass ratio (<i>k</i>) on the HIPEs' properties were investigated. Re... |
41717367 | Artificial intelligence in functional food innovation: Bioactive enhancement and formulation optimization: A quasi-systematic review. | Artificial intelligence (AI) is increasingly integrated into functional food research. This quasi-systematic review analyzes 53 peer-reviewed studies (2015-2025) to outline current applications and emerging directions, including the underexplored domain of antioxidant food development. The review attempts to provide an... |
41696592 | Few-shot molecular property optimization <i>via</i> a domain-specialized large language model. | Large language models (LLMs) have revolutionized machine learning with their few-shot learning and reasoning capabilities, demonstrating impressive results in fields like natural language processing and computer vision. However, when applied to the domains of biology and chemistry, current LLMs face substantial limitat... |
41691918 | Bottom-up synthesis of bridged Bis(β-cyclodextrin)-functionalized chiral COFs@SiO<sub>2</sub> for enantioseparation in liquid chromatography. | Chiral covalent organic frameworks (CCOFs) have attracted considerable attention as promising materials for enantioseparation. In this work, a series of β-cyclodextrin-bridged chiral COFs with precisely tunable chiral-site densities were synthesized via a bottom-up strategy using the 1,3,5-tris(4-aminophenyl)benzene (T... |
41679212 | Visible light - driven antibacterial packaging based on whey protein isolate amyloid fibrils for food preservation. | Imbalances in moisture and oxygen in food packaging's microenvironment easily cause pathogenic bacteria proliferation, accelerating spoilage. Utilizing visible light from the storage environments as an excitation source to achieve environmentally adaptive antibacterial action represents an effective strategy. In this s... |
41671828 | Engineering synergistic intermediate interaction in metal-organic framework-derived Ru/metal oxide catalysts to boost hydrogen oxidation reaction. | The kinetics of hydrogen oxidation reaction (HOR) in alkaline media is sluggish, exhibiting a decline by several orders of magnitude in comparison to that in acidic media. While Ru presents a cost-effective alternative to benchmark Pt with comparable hydrogen binding energy and enhanced oxophilicity, its performance is... |
41671770 | Molecular dynamics and energy analysis of ultrasonic cavitation effects on aged asphalt. | The physicochemical degradation of asphalt during long-term service leads to pronounced aging, characterized by increased molecular aggregation, elevated viscosity, and degraded mechanical performance. Ultrasonic treatment has shown potential for reducing the viscosity of heavy oils and asphaltic materials; however, th... |
41666575 | Thermal activation in oxidative model drives catechin assembly into theaflavins with enhanced antioxidant capacity. | Theaflavins are important bioactive pigments in tea, but their non-enzymatic formation pathways under heating remain incompletely understood. This study investigated the temperature-dependent formation of four theaflavins using aqueous catechin model systems. Potassium ferricyanide was used as a controlled oxidant to i... |
41662884 | A versatile self-adjuvanting macro-microporous ZIF-8@Mn MOF platform for efficient antigen capture and presentation to boost antitumor immunity. | Personalized in situ tumor vaccines (ISTVs) have emerged as a promising approach to activating potent T cell-mediated anticancer immunity through the induction of immunogenic cell death (ICD) and the subsequent release of tumor-associated antigens (TAAs). However, their efficacy is limited by non-specific ICD, inadequa... |
41655723 | The double-edged sword of Dioscorea bulbifera L.: Recent advances in its pharmacological benefits and hepatotoxicity, and the quest for detoxification strategies. | <h4>Ethnopharmacological relevance</h4>Dioscorea bulbifera L., the dried tuber of which is known as "Huangyaozi ()" in Traditional Chinese medicine (TCM), has a history of medicinal use spanning centuries within TCM and other traditional medical systems. It is traditionally utilized to dispel nodules and reduce goiter,... |
41654930 | Computational design of a novel multi-epitope vaccine candidate against group A rotavirus. | Rotaviruses A (RVA) are the most common cause of diarrhea-related death in children under the age of five. Because RV vaccines are live attenuated, their use is limited. This work aimed to develop a multi-epitope vaccination against RVA using reverse vaccinology approaches. The viral protein 6 (VP6) was targeted for pr... |
41654868 | FSHR-targeting tetrahedral DNA frameworks ameliorate ovarian aging through oxidative stress elimination. | Ovarian aging, characterized by declining ovarian reserve, is a pacemaker of aging in the female body. Oxidative stress leads to apoptosis, mitochondrial dysfunction, inflammation, and telomere shortening, accelerating ovarian aging. Scavenging reactive oxygen species (ROS) has been shown to delay ovarian aging; howeve... |
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