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41654811 | Next-generation dynamic and combinatorial nanotherapies for liver cancer: mechanisms, current advances and future perspectives. | Liver Cancer, one of the most lethal cancers in adults, is distinguished by its aggressive invasion, distinctive tumor microenvironment (TME) and resistance to standard treatments, posing challenges. The TME and fibrotic extracellular matrix (ECM) hampers effective drug distribution; hence, new developments in therapeu... |
41654805 | RAP-peptide functionalized biomimetic nanoformulation with pathological ROS/pH-responsive drug release for target immunotherapy in glioma. | Glioblastoma (GBM) is one of the most aggressive malignancies of the central nervous system. Gemcitabine (GEM), a pyrimidine analogue with broad-spectrum anticancer activity, can activate the cGAS-STING pathway and alleviate the immunosuppressive microenvironment of GBM. However, its clinical application is hampered by... |
41654686 | Microneedles self-implanting Astragalus polysaccharides-hybridized composite hydrogel combined with minoxidil to enhance in situ anti-androgenetic alopecia. | In the current study, polysaccharides (APS) extracted from the dried roots of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao were demonstrated to promote hair regeneration. However, with an average molecular weight of 20,000, they exhibit poor transdermal absorption. To enhance local efficacy, we s... |
41654633 | An aptamer-based "Gate-lock-key" strategy for metal-organic framework nanozyme-catalyzed colorimetric detection of multidrug-resistant bacteria. | An aptamer-gated metal-organic framework-based biosensing platform for highly sensitive detection of multidrug-resistant bacteria (MDRB) has been developed. This biosensing platform utilizes aptamers as specific "gated" switches, which are integrated with the UiO-66-NH₂ MOFs to construct a "gated" sensing system loaded... |
41654558 | Assessing conformation validity and rationality of deep learning-generated 3D molecules. | Recent advancements in artificial intelligence (AI) have revolutionized the field of 3D molecule generation. However, the lack of effective evaluation methods for 3D conformations limits further improvements. Current techniques, in order to achieve the necessary speed for evaluating large number of AI-generated molecul... |
41654520 | A combinatorial synthetic strategy for developing genome-editing protein-delivery agents targeting mouse retina. | CRISPR/Cas9-based gene-editing technologies offer promise for treating inherited retinal diseases (IRDs), however safe and efficient ocular delivery of precision editors remains challenging. To address this challenge, we report a class of Coomassie brilliant blue (CBB)-derived lipidoids that bind and deliver proteins. ... |
41654506 | Discovery of antimicrobial peptides targeting Acinetobacter baumannii via a pre-trained and fine-tuned few-shot learning-based pipeline. | Acinetobacter baumannii, a robust Gram-negative bacterium known for causing nosocomial infections, exhibiting multidrug resistance, and lacking antimicrobial peptides that target it, remains hard to treat. Here, we report a few-shot learning pipeline integrating classification, ranking, and regression modules. Each mod... |
41654490 | Cooperative anion activation at a cobalt center through ion pairing and ligand design. | Weakly coordinating anions (WCAs) are commonly used to stabilize high-valent, electrophilic transition-metal complexes, owing to their low nucleophilicity and minimal coordinating ability. Here, we present a cobalt platform supported by a tris(2-pyridyl)(N-picolyl)imidazolidine ligand (Py<sub>4</sub>Im) that generates ... |
41653431 | Optimizing HostGuest Interaction Sites in Metal-Organic Frameworks for Benchmark One-Step Ethylene Purification. | Purifying ethylene from ternary acetylene/ethylene/ethane (C<sub>2</sub>H<sub>2</sub>/C<sub>2</sub>H<sub>4</sub>/C<sub>2</sub>H<sub>6</sub>) mixture in one-step requires preferential adsorption for C<sub>2</sub>H<sub>2</sub> and C<sub>2</sub>H<sub>6</sub>, which is challenging due to the intermediate physicochemical pr... |
41653203 | Metabolism of bile salts in the estrogen degrading bacterium Caenibius tardaugens. | Bile salts are conjugated steroids with digestive functions in vertebrates that reach the ecosystem upon excretion. Their environmental degradation by bacteria resembles the steroid nucleus catabolism that uses the 9,10-seco pathway, although there are two variants depending on whether the hydroxyl group at C-7 is elim... |
41653146 | Adsorption and Energy Storage Properties of a Zeotropic Working Fluid in MOF-5. | An in-depth understanding of the adsorption and energy storage mechanism of a zeotropic working fluid in metal-organic framework materials is significant for the application of nanomaterials in thermodynamic cycles. In this study, the adsorption behavior and energy storage properties of R32, R1234yf, and their mixtures... |
41653122 | Coordination Polymers Assembled from Flexible Tricarboxylate Linkers: Hydrothermal Synthesis, Structural Diversity, and Catalytic Features. | The molecular design of coordination polymers (CPs) and metal-organic frameworks (MOFs) has attracted increasing attention in the areas of inorganic chemistry and functional materials. In this study, a new series of 2D CPs and 3D MOFs was hydrothermally assembled from metal(II) chlorides and 2,2'-((4-carboxy-1,2-phenyl... |
41653112 | DFDD: A Cloud-Ready Tool for Distance-Guided Fully Dynamic Docking in Host-Guest Complexation. | Fully dynamic sampling of host-guest inclusion remains difficult because conventional docking and conventional molecular dynamics simulations can sample inclusion, but crystal-like binding is typically stochastic and difficult to reproduce. Here, we introduce DFDD (Distance-Guided Fully Dynamic Docking), a cloud-ready ... |
41653114 | Synergistic MOF-on-MOF Integration for Enhanced Energy Storage Performance. | Transition-metal-based metal-organic frameworks (MOFs), especially Ni-MOFs, have emerged as attractive candidates for electrochemical energy storage owing to their considerable theoretical specific capacitance. However, their poor electrical conductivity severely limits the overall electrochemical performance in superc... |
41653064 | Research progress of endophytes and their secondary metabolites in <i>Morus</i> plants. | <i>Morus</i> plants are globally recognized as essential economic woody species. Investigating cross-kingdom interaction mechanisms between <i>Morus</i> and endophytes, along with the regulatory networks of secondary metabolism, is crucial for sustainable agricultural development and innovative drug research. However, ... |
41652950 | Monomeric Fluorescence of H-Aggregates in a Series of 2-(Hydroxyphenyl)benzoxazoles Derivatives. | The exploitation of molecular self-assembly, which leads to the formation of aggregates, represents one of the most crucial approaches in the fabrication of advanced functional materials. A fundamental aspect in this area is the development of novel strategies to construct supramolecular architectures with new (unusual... |
41651917 | DFT study of frontier orbitals and NLO properties of a phenanthroline and nitrophenol complex. | The hydrogen-bond charge transfer complex (HB-CTC) formed between the donor, 1,10-phenanthroline (Phen), and the π-acceptor, p-nitrophenol (PNP), has been thoroughly investigated through theoretical studies. The molecular structure and the HOMO-LUMO energy gap (ΔE<sub>H-L</sub>) of this complex have been investigated b... |
41970710 | Transformative biomechanics and mechanobiology breakthroughs shaping the future of health and medicine. | The mechanical environments endured by the human body profoundly influence life activities across different scales, from single molecules to complicated systems. Gaining insight into the mechanical factors and their biological implications is crucial for deciphering physiological and pathological processes and advancin... |
41938358 | Engineering high-efficiency mutants of the transposase ISDra2 TnpB via protein-generative models and energy-optimized design. | Transposon-associated TnpB is a compact and versatile gene editor that holds significant promise in the life sciences. However, current engineering strategies for TnpB are limited, resulting in low cleavage efficiency in mammalian cells that restricts its broader use. In this study, we developed a method termed TnpB-GM... |
41884274 | The Landscape of Ferritin Nanocages for Neurodegenerative Diseases Treatment. | The blood-brain barrier (BBB) is a sophisticated structure composed of brain capillary endothelial cells, basement membrane, and neuroglial membrane, which strictly regulates substance exchange between the blood and brain tissue. While maintaining the homeostasis of the central nervous system, it blocks the entry of ov... |
41884273 | Targeted Nanoboron Delivery Platform for Boron Neutron Capture Therapy in Refractory Solid Tumors. | Boron neutron capture therapy (BNCT) represents a promising binary radiotherapy for refractory solid tumors. However, its clinical translation has been historically constrained by the suboptimal pharmacokinetics of conventional boron agents (eg, BPA and BSH), characterized by low tumor selectivity and rapid clearance. ... |
41853170 | Calixarene-Based Nanostructures for Delivering Coumarin 6 for Tumor-Cell Imaging and Photoinduced Toxicity. | Fluorescence imaging techniques are emerging as safer and more sensitive alternatives to radionuclide-based approaches for cancer diagnosis. Entrapping fluorophores that also act as photosensitizers within nanocarriers is an effective strategy to enhance their stability, performance, and selective delivery to tumor tis... |
41852719 | High-reactivity precursor C<sub>2</sub>N<sub>3</sub>H and its photo-induced stepwise growth toward 2D graphitic carbon nitride clusters. | To investigate the precursors and growth mechanisms of two-dimensional C<sub>x</sub>N<sub>y</sub> materials, we performed laser ablation mass spectrometry and spectroscopy on graphitic carbon nitride. A series of clusters, [(C<sub>2</sub>N<sub>3</sub>)<sub>n</sub>H<sub>n-1</sub>]<sup>-</sup> (n = 1-4), were identified,... |
41831988 | Harnessing cyclodextrins for enhanced CO<sub>2</sub> management: Recent advances and perspectives for sustainable applications. | The critical need to address increasing atmospheric CO<sub>2</sub> levels has motivated efforts to develop sustainable materials for carbon capture, utilization and storage (CCUS). Cyclodextrins (CDs) have emerged as practical and versatile candidates for improving CO<sub>2</sub> handling due to their naturally occurri... |
41777554 | Harnessing oligonucleotide architecture for potent multivalent inhibition of human carbonic anhydrases. | This study presents the design and synthesis of a novel class of carbonic anhydrase inhibitors (CAIs) using oligonucleotides as an original multivalent platform. Single-stranded oligonucleotides bearing one to four terminal alkyne moieties were prepared by solid-phase synthesis using the commercially available 2'-<i>O<... |
41768620 | Theranostic Rare-Earth-Doped Carbon Dots: An Effective Nanocarrier For Methotrexate Delivery in Colon Cancer. | The present work focuses on methotrexate (MTX)-conjugated terbium-doped carbon dots (CDTb) as an innovative drug delivery platform for targeted colon cancer therapy using Caco-2 cell lines. Briefly, carbon dots (CDs) were synthesized via a microwave-assisted method, subsequently doped with terbium using a chemical prec... |
41767281 | Structural Dispersity as a Determinant of Li-Ion Transport in Ethylene-Oxide-Based Graft Polymer Electrolytes. | Graft polymers with oligo-(ethylene glycol) (OEG) side chains and poly-(meth)-acrylate backbones have been commonly studied as polymer electrolytes (PEs) owing to the ability of oligoether segments to coordinate Li<sup>+</sup> ions. However, when poly-[oligo-(ethylene glycol) methyl ether methacrylate]-s (P-(OEG)-MAs) ... |
41756169 | Recent advances in Ti<sub>3</sub>C<sub>2</sub>T <sub><i>x</i></sub> MXene-based composites for electrocatalytic applications. | Electrocatalysis is central to the development of sustainable energy conversion technologies and environmental remediation systems, yet the rational design of high-performance, cost-effective, and durable electrocatalysts remains a fundamental challenge. In recent years, MXenes, a rapidly expanding family of two-dimens... |
41755879 | Highly Potent Th1-Type NKT Cell Agonists as Immunotherapeutic Agents via Conformational Restriction Design. | Th1-selective natural killer T (NKT) cell agonists are promising immunotherapeutic agents due to their ability to promote cellular immunity against tumors and intracellular pathogens. However, the development of potent Th1-biased NKT cell agonists has remained slow despite decades of structural modification of the prot... |
41751284 | The Impact of Genetics on Pediatric Interstitial Lung Diseases: A Narrative Literature Review and Clinical Implications. | <b>Background</b>: Interstitial lung diseases (ILDs) are a heterogeneous group of disorders characterized by variable degrees of inflammation and fibrosis affecting the pulmonary interstitium. Advances in molecular biology and genetics have greatly expanded our understanding of ILD pathogenesis, uncovering novel mechan... |
41745748 | ADP-Ribosylation of Cytidine: A Novel Nucleic Acid Modification Reversed by NADAR Hydrolases. | ADP-ribosylation of nucleic acids is a modification found in both eukaryotes and bacteria, where it contributes to genome maintenance but can also serve as a toxic mechanism used by bacterial toxins to disrupt essential cellular processes. This modification is catalysed by ADP-ribosyltransferases and can be reversed by... |
41744725 | Electrochemical (Bio)Sensors Based on Nanotechnologies for the Detection of Important Biomolecules in Plants and Plant-Related Samples: The Future of Smart and Precision Agriculture. | Considering the present environmental concerns, nanomaterial-based methods should be applied to achieve the bioeconomic sustainability initiatives and climate change mitigation. Plants and plant extracts are one of the most underused biomass and bioactive ingredients resources. Moreover, nowadays crop loss is one of th... |
41729729 | Fabrication of Oriented Mixed-Matrix Metal-Organic Framework Membranes for Molecular Separation. | The quest for energy-efficient separations is of prime importance. Membrane-based separation can alleviate excessive energy penalties associated with separations. Mixed-matrix membranes (MMMs), combining easily processable polymers and highly selective adsorbents, offer great potential to translate remarkable adsorbent... |
41728619 | Molecular pattern of acquiring upper respiratory infection. | Upper respiratory tract infections (URIs) are a significant public health concern. Human behavior plays a crucial role in how often infected individuals come into contact with susceptible individuals. Among the key factors influencing the seasonality of these infections, variations in temperature and absolute humidity ... |
41728199 | Influence of substitution patterns on the antimicrobial properties of pyrrole sulfonamide scaffolds. | Two series of sulfonamide derivatives featuring a pyrrol-2-one core were synthesized and evaluated for their antimicrobial and anti-virulence features using <i>Escherichia coli</i>, <i>Pseudomonas aeruginosa</i>, and <i>Candida albicans</i> strains, in planktonic and biofilm growth state. Fourteen substituents were int... |
41727998 | Effects of flowering period and cultivation practices on volatile organic compounds in Sanqi flowers. | Sanqi flower holds broad application prospects in the food industry due to its rich bioactive components and potential health benefits. However, limited information is available regarding the variation of volatile organic compounds (VOCs) in the Sanqi flowers within Sanqi-<i>Pinus armandii</i> (SPA) and Sanqi-<i>Pinus ... |
41727877 | Bridging light and sound: A spironaphtopyran-rhodamine dyad with high-contrast photoswitching between fluorescence and photoacoustic signal. | Fluorescence and photoacoustic imaging are complementary modalities that provide distinct advantages for biological imaging: fluorescence microscopy offers high sensitivity and resolution, while photoacoustic imaging enables deeper penetration in complex tissue. Leveraging the strengths of both modalities through optic... |
41727487 | Metabolic control of neuroinflammation: focus on itaconate and its derivatives in CNS disorders. | The activation of microglia, which are the resident immune cells of the central nervous system (CNS), underpins the pathogenesis of neuroinflammatory and neurodegenerative diseases. Metabolic reprogramming has recently been recognized as a critical mechanism that regulates microglial activation because distinct activat... |
41727457 | <i>In silico</i> design of a multiepitope subunit vaccine targeting <i>Salmonella enterica</i> serovar Infantis: an immunoinformatics and reverse vaccinology approach. | <i>Salmonella enterica</i> serovar Infantis is an emerging zoonotic pathogen increasingly linked to poultry and multidrug-resistant human infections. Existing vaccines lack serovar-specific efficacy, underscoring the need for targeted immunization strategies. In this study, we employed an immunoinformatics and reverse ... |
41727444 | Glycosaminoglycan binding to soluble CX3CL1 impacts monocyte migration <i>in vitro</i>. | <h4>Introduction</h4>In addition to providing shear-resistant cell-cell adhesion in its natural membrane-bound form, the soluble variant of CX3CL1 (or fractalkine) promotes strong cell migration through signaling via its unique G-protein-coupled receptor CX3CR1 on monocytes, macrophages, T-cells, and NK-cells. To induc... |
41727324 | Bioinspired artificial nanovesicles engineered from 3D spheroid-cultured UC-MSCs enhance angiogenic activity <i>in vitro</i>: functional proof-of-concept for ischemic applications. | Artificial nanovesicles (aNVs) derived from cells may mimic naturally secreted extracellular vesicles (EVs) and are becoming popular in biomedical research. We isolated aNVs from two-dimensional (2D)- and three-dimensional (3D)-cultured umbilical cord-derived mesenchymal stem cells (UC-MSCs) (aNVs<sup>2D</sup> and aNVs... |
41727277 | Oral stem cells in combination with hydrogels as biomimetic bioactive platforms for periodontal tissue engineering. | Oral stem cells possess the capability to repair themselves and multipotent differentiation capacities, indicating that they have significant prospects in regenerative medicine. Nonetheless, due to the circulatory system's rapid clearance capability, they can only work consistently in certain areas for tissue healing. ... |
41727200 | Optimal timing of enteral nutrition initiation in critically ill patients: a network meta-analysis. | <h4>Background</h4>Nutritional support is pivotal in managing critically ill patients. Enteral nutrition, which preserves intestinal mucosal barrier function and modulates immune-metabolic homeostasis, is the preferred nutritional support strategy. However, the optimal timing for initiating EN remains controversial: so... |
41726695 | Significant Activity of Pytren-2Q, a 2‑Quinoline Polyamine Compound, against High-Concern Human Pathogenic Fungi. | In view of the worldwide expansion of life-threatening invasive fungal diseases (IFDs) and fungal drug resistance, new antifungal drugs are urgently needed. To guide research and public health policies, the World Health Organization (WHO) specified 19 priority-concern human mold and yeast pathogens associated with seri... |
41726613 | Copper-Based Metal-Organic Frameworks for Sustainable Catalysis: Mechanistic Insights, Stability, and Emerging Research Directions. | Metal-organic frameworks (MOFs) have emerged as a versatile class of porous crystalline materials due to their tunable structures, large surface areas, and diverse functionalities. Among them, copper-based MOFs (Cu-MOFs) are of particular interest because of the redox activity of copper centers, flexible coordination c... |
41726153 | From basic biology to engineered therapies: the keratinocyte stem cell playbook. | Keratinocyte stem cells (KSCs) are the principal drivers of epidermal renewal, barrier maintenance, and wound repair. Their ability to alternate between self-renewal and differentiation is orchestrated by tightly integrated extrinsic and intrinsic programs that ensure tissue stability while enabling rapid regeneration ... |
41725950 | pH-responsive nanozymes: multifunctional platforms for biomedical catalysis toward clinical translation. | As an emerging class of smart nanomaterials, pH-responsive nanozymes are capable of realizing dynamic regulation of catalytic activity according to microenvironmental acidity and alkalinity. The material system encompasses noble metals, metal oxides, metal sulfides, carbon-based nanozymes, and metal-organic frameworks.... |
41725811 | Genome-wide analysis of extended-spectrum beta-lactamase-producing <i>Escherichia coli</i> from seafood in Bangladesh: population structure, resistome, virulome, and global dissemination patterns. | <h4>Objectives</h4>This study aimed to identify multilocus sequence type (MLST), serotype, average nucleotide identity (ANI), antimicrobial resistance genes (ARGs), virulence genes (VGs), and mobile genetic elements (MGEs) from whole-genome sequences of 10 <i>Escherichia coli</i> isolated from seafood in Bangladesh and... |
41718402 | Transplacental Antibody Transfer: Mechanisms, Pregnancy-Related Disruptions, and Emerging Experimental Models. | The transplacental transfer of maternal immunoglobulin G from the mother to the foetus is central for providing immunity in early life, resulting in full-term newborns having IgG repertoires and levels similar to those of their mothers. The neonatal Fc receptor is recognised as the primary transporter of IgGs across th... |
41716339 | Oral delivery of engineered <i>Lactococcus lactis</i> microcapsules expressing antioxidant enzymes for inflammatory bowel disease: Mechanisms of intestinal barrier repair and microbiota modulation. | Inflammatory bowel disease (IBD) is characterized by elevated levels of reactive oxygen species (ROS) and pro-inflammatory cytokines, alongside disrupted gut microbiota. Therefore, eliminating ROS in the inflammatory site by antioxidant enzymes such as catalase (CAT) and superoxide dismutase (SOD) represents a promisin... |
41710202 | Direct metathesis of carbon-carbon <i>σ</i>-bonds at a versatile macrocycle-supported diiron platform. | The metathesis of C-C <i>σ</i>-bonds holds potential as an atom-economical strategy for molecular engineering. While this reaction has been achieved in industrial and research settings, the former is energy-intensive and the latter has only been reported to operate either indirectly, proceeding through well-known <i>π<... |
41705127 | Introducing CLipPA lipid chemodiversity to enzymatically truncated polymyxin B: a soft drug strategy to combat Gram-negative pathogens. | A chemodiverse library of new semi-synthetic antimicrobial peptides is reported herein. The polymyxin B nonapeptide (PMBN) holds promise as a developmental platform to access potent antimicrobial lipopeptide derivatives that circumvent the serious side effects of natural polymyxins used in clinical settings. By combini... |
41705136 | Gemini surfactant-stabilized cubosomes for enhanced topical delivery of 5-fluorouracil in cutaneous squamous cell carcinoma. | Cutaneous squamous cell carcinoma (cSCC) is a prevalent non-melanoma skin cancer. Topical chemotherapy offers a non-invasive alternative to surgical treatments, yet the therapeutic efficacy of conventional agents like 5-fluorouracil is hindered by poor skin permeability and systemic side effects. In this study, we deve... |
41705031 | Modulating halide leaving-group trends through recognition by bisboranes. | Modulating the intrinsic leaving-group tendency of halides remains a long-standing challenge in synthetic chemistry. Herein, we reported dynamic anion recognition and demonstrated its application in nucleophilic substitution reactions, enabling an apparent reversal of the halide leaving-group tendency sequence. A biden... |
41704233 | Polyplex of peptide-mannan and RNA for intranasal delivery of TGF-β siRNA in treatment of pulmonary fibrosis. | Pulmonary fibrosis is a progressive, severe respiratory disease, often considered terminal, with a typical life expectancy of only a few years. It is marked by excessive deposition of extracellular matrix proteins, driven by a complex interplay of profibrotic signaling pathways, including contributions from monocyte-de... |
41694226 | MXene quantum dots in catalysis and energy conversion: structure-activity insights and emerging prospects. | MXene quantum dots (MQDs) have emerged as a promising nanoscale platform for sustainable energy conversion. Owing to quantum confinement, MQDs exhibit discrete electronic states and a high surface-to-volume ratio, while inheriting the excellent electrical conductivity and chemical tunability of their parent MXenes. The... |
41690234 | Efficient and selective capture of uranium(VI) by MIL-125/MXene nanocomposites: Synergistic enhancement via interfacial engineering. | The rapid development of the nuclear industry has made the efficient treatment of uranium-containing wastewater a significant challenge in environmental radiochemistry. This study aimed to develop a high-performance adsorbent for the removal of UO<sub>2</sub><sup>2+</sup> from water. A series of MIL-125/Ti<sub>3</sub>C... |
41684026 | Host Glycan-Lectin Interplay in SARS-CoV-2 Infection. | Glycan-mediated processes can be critical determinants of viral attachment and entry, yet for enveloped RNA viruses, including SARS-CoV-2, their mechanistic roles remain incompletely defined. This review synthesizes current structural and functional evidence for glycan engagement during SARS-CoV-2 attachment and entry.... |
41684018 | 3,4-Dihydroxybenzaldehyde Exerts Anti-Alzheimer's Effects by Inhibiting Aβ Protofibril Assembly and Activating Antioxidant Defense Mechanisms. | 3,4-Dihydroxybenzaldehyde (DBD) is a polyphenolic active constituent derived from <i>Gastrodia elata</i>. Its characteristic phenolic structure is associated with diverse bioactivities, such as anti-inflammatory, antioxidant, and cardioprotective effects. However, its role and underlying mechanisms in combating Alzheim... |
41684013 | Molecular Mechanisms of <i>Trichosanthes kirilowii</i> in Response to Root-Knot Nematode Infection. | Root-knot nematode (RKN) infection poses a serious threat to the yield and quality of the perennial medicinal plant <i>Trichosanthes kirilowii</i> (<i>T. kirilowii</i>) in cultivation. However, its response mechanisms remain unclear. This study analyzed root growth and transcriptomic data at various root-knot nematode ... |
41683548 | Auranofin Combination Therapy: A New Frontier in Cancer Treatment. | Auranofin, a gold(I)-based compound initially developed for the treatment of rheumatoid arthritis, has emerged as a promising anticancer agent with a multimodal mechanism of action. This review comprehensively examines the therapeutic potential of auranofin in oncology focusing on its ability to synergize with conventi... |
41683554 | Water-Soluble Palladium Complexes with 1,10-Phenanthroline-Synthetic Aspects, Crystal Structure, DNA-Binding and In Vitro Antibacterial Evaluation. | Obtaining water-soluble palladium complexes capable of interacting with DNA is an important synthetic task in medicinal chemistry. The interaction of [Pd(phen)(OAc)<sub>2</sub>] (phen = 1,10-phenanthroline) with pivalic acid (<sup>t</sup>BuCOOH) and trifluoromethanesulfonic acid (HOTf) leads to the formation of the mol... |
41683542 | Small Particles, Big Impact: Inorganic Nanotechnology for Glioblastoma. | <h4>Background</h4>Glioblastoma Multiforme (GBM) is one of the most aggressive primary brain tumors, with a median survival of only 15-17 months. Treatment failure is largely driven by the Blood-Brain Barrier (BBB), which restricts the delivery of most conventional therapeutics and shields invasive tumor regions from s... |
41683183 | Engineering Allosteric Transcription Factor-Based Biosensors: Advances and Prospects for Modern Food Contaminant Monitoring. | Allosteric transcription factor (aTF)-based in vitro biosensors constitute a class of detection tools formed by the functional coupling of the ligand-binding domain of aTFs with a reporter system. Owing to advantages such as high specificity and sensitivity, these biosensors have emerged as a research hotspot in the fi... |
41683180 | Monitoring Antioxidant Preservation in Microwave-Dried Tea Using H<sub>2</sub>O<sub>2</sub>-Responsive Electrochemical Sensor. | Considering the demand for nutritional assessment and product quality control in the tea industry, this work develops an effective electrochemical sensor based on gold nanoparticles electrodeposited onto a zeolitic imidazolate framework (Au/MOF(Zn)) for evaluating the antioxidant activity of tea subjected to microwave-... |
41683177 | Analytical Methodologies for Benzo[a]pyrene in Foods: A Review of Advances in Sample Preparation and Detection Techniques. | Benzo[a]pyrene (BaP), a potent carcinogenic polycyclic aromatic hydrocarbon, is a critical food contaminant originating from environmental deposition and thermal processing, posing a significant threat to public health and driving stringent global regulations. This review critically examines recent advancements in anal... |
41681683 | VviAMT4;1 Is a High-Affinity Ammonium Transporter in Table Grape. | Ammonium transporters (AMTs) are a class of membrane-associated proteins that play crucial roles in the uptake and transport of ammonium (NH<sub>4</sub><sup>+</sup> or NH<sub>3</sub>). In this study, an ammonium transporter-encoding gene <i>VviAMT4;1</i> was isolated and identified from table grape 'Yanpu No.2'. Notabl... |
41677565 | Aluminum-Induced Surface-Enhanced Raman Scattering in Ti-Al-Ti Sandwich Multilayer Thin Films. | A series of Ti-Al-Ti sandwich thin films with different Al layer thicknesses was prepared via magnetron sputtering. The Al layer facilitated Ti-Al metal coupling within the films, which significantly strengthened the localized surface plasmon resonance (LSPR) and obtained more "hot-spots", ultimately leading to a remar... |
41669747 | cShot: spatial dynamic imaging of cell cycle-dependent miRNA heterogeneity using dynamic DNA patterns. | Profiling cell cycle phase progression and determining how cells respond to external stimuli through miRNA quantification will enable substantial improvements in therapeutic assessment. However, miRNA evaluation is challenging due to its transient nature and the complex cellular environment. Here, we report "cShot" (ce... |
41669670 | Detection of Cancer-Associated Mutations Using Primer Exchange Reaction-Based Signal Amplification and Lateral Flow Assays. | The ability to sensitively and specifically detect cancer-associated nucleic acids carrying single-nucleotide mutations is critical for early cancer detection, patient stratification, and personalized treatment, particularly through non-invasive liquid biopsy approaches. Detecting low-abundance nucleic acid fragments-p... |
41660639 | Designing MOF-Cellulose Bio-Aerogels for Electromagnetic Management and Fire-Acoustic Safety. | Lightweight multifunctional aerogels hold great promise in applications, e.g., electromagnetic microwave absorption, thermal insulation, and acoustic damping. However, conventional aerogels often suffer from limited functionalities, complicated manufacturing, and poor sustainability. Metal-organic frameworks (MOFs), wi... |
41660641 | Integrin-Mediated Mechanosensing of Modeled Lymph Node Microenvironment Promotes T Cell Activation via Nuclear Deformation. | Upon tumor metastasis, lymph nodes (LNs) undergo mechanical stiffening, yet how this change influences T cell activation within the microenvironment remains incompletely understood. In particular, the dynamic mechanical forces during activation are transduced by cell-extracellular matrix (ECM) interactions, while cell-... |
41660632 | Dual Sensitization Enables Synergistic Photodynamic Therapy and Radiotherapy for Breast Cancer. | Radiotherapy (RT) and photodynamic therapy (PDT) for breast cancer are limited by tumor hypoxia and suboptimal photosensitizer performance. We developed folate-modified copper-doped carbon dots and loaded them with 5-aminolevulinic acid (ALA) to yield FCA, a nanoplatform that executes cascade nanozyme activities to rem... |
41659351 | Carbon dots and metal-organic frameworks based nanohybrids for improved biosensing and biomedical applications. | Composites of carbon dots (CDs) and metal-organic frameworks (CDs@MOFs) have emerged as a novel class of hybrid nanomaterials that integrate the high porosity and structural versatility of MOFs with the outstanding optical properties and biocompatibility of CDs. Although relatively new, these materials have attracted g... |
41659329 | Nitric oxide-releasing hyaluronic acid as an antibacterial and immunomodulatory acne therapeutic. | Acne vulgaris (acne) is a common skin disorder associated with significant psychosocial impact. Current clinical therapies include topical and systemic antibiotics, benzoyl peroxide, and retinoids. While moderately effective, these clinical therapies fail to target all four major pathogenic causes of acne and are assoc... |
41659315 | Recent advances of azomethine ylides for the synthesis of natural and synthetic bioactive pyrrolidines and spiropyrrolidines. | 1,3-Dipole-based nitrogen containing carbanion, particularly azomethine ylide, is widely used in cycloaddition reactions. It has important and widespread application not only limited in the synthesis of core structural motifs like pyrrolidine and spiropyrrolidines but also in stereocontrolled dipolarophile for building... |
41659321 | Fabrication of a zein-phloretin complex and nanoparticles: interaction mechanism and characterization. | Due to its capacity to form complexes with polyphenols and to self-assemble as nanoparticles, zein could be utilized as an excellent carrier for polyphenols. The objective of this study was to examine the interaction between zein and phloretin (PHL) through multispectral analysis and molecular docking, and to prepare a... |
41659325 | Multifaceted boron nitride nanomaterials: a comprehensive review of synthesis, property engineering and multidisciplinary applications. | Boron nitride (BN) nanomaterials, spanning zero-dimensional (0D) quantum dots, 1D nanotubes, 2D nanosheets, 3D and macroscopic architectures, have garnered emerging attention as functional analogs to carbon-based nanomaterials. Their wide band gap, high thermal conductivity, electrical insulation, and chemical inertnes... |
41659323 | How topology governs cation affinity: protonation and metal coordination in 1- and 9-azahomocubane. | The interaction of cationic species with aza-homocubanes provides a powerful platform for probing the effects of cage topology on electronic structure and noncovalent binding phenomena. Here, density functional theory (DFT) calculations were employed to investigate the complexation of 1-azahomocubane and 9-azahomocuban... |
41658394 | Synthesis and biological evaluation of carabrol derivatives. | Carabrol, isolated from <i>Carpesium macrocephalum</i> Franch. & Sav., showed anti-inflammatory potential in LPS-induced RAW264.7 murine macrophages. We transformed the structure of carabrol and modified the carbon atoms at positions 11 and 13 to obtain a series of carabrol derivatives. The anti-inflammatory activity o... |
41657973 | Innovative Nanomaterial-Based Approaches for the Recognition of Amphetamine in Attention Deficit Hyperactivity Disorder Management. | The rising incidence of amphetamine misuse, particularly in the context of attention deficit hyperactivity disorder treatment, underscores the urgent need for sensitive and effective detection methods. This review examines innovative nanomaterial-based approaches for AMP detection, emphasizing their advantages over con... |
41657654 | Preparation strategies and biomedical applications of DNA hydrogels. | With the progressive development of DNA nanotechnology and synthetic biology, the applications of DNA have expanded from traditional genetics study to materials science. By employing DNA as a structural framework or cross-linking agent, DNA hydrogels retain a hydrophilic three-dimensional (3D) network structure similar... |
41655957 | Serum Response Factor (SRF) promotes actin cytoskeletal organization in adipocytes to support adaptive hypertrophic expansion and tissue remodeling during obesity in mice. | <h4>Background</h4>Adipocyte hypertrophy, the unique capacity of adipocytes to enlarge in response to energy surplus, is a crucial determinant of metabolic health during obesity. Nonetheless, the molecular mechanisms governing this adaptive growth remain incompletely characterized.<h4>Methods</h4>Super-enhancer landsca... |
41655916 | The fabrication of chitosan/MOF smart packaging composite film and its application for simultaneous freshness preservation and monitoring of yak meat. | Sustainable, multifunctional packaging with real-time freshness monitoring and shelf-life extension is crucial for beef quality and safety. This research investigates the incorporation of an ammonia-sensitive cobalt-based metal-organic framework (Co-MOF) into a chitosan (CS) polymer matrix to develop a functional compo... |
41655336 | Curcumin-modified Mn-based metal-organic framework for synergistic sonodynamic and cascade anti-oxidation therapy of bacterial osteomyelitis. | The osteomyelitis induced by methicillin-resistant Staphylococcus aureus (MRSA) remains a formidable clinical challenge due to persistent bacterial infection, chronic inflammation, and impaired bone regeneration. Herein, a multi-functional nanoplatform is prepared by manganese-based porphyrinic metal-organic frameworks... |
41653833 | Balancing Demineralisation and Collagen Integrity: A Nanoscale Analysis of Etching Time in Human Dentin. | <h4>Objectives</h4>To investigate the effect of varying phosphoric acid etching times on dentin demineralisation and collagen fibril morphology and to identify a time-dependent balance between sufficient mineral removal and preservation of collagen nanostructure.<h4>Methods</h4>Dentin specimens from human third molars ... |
41653733 | Thiol-functionalized Cu-MOF@biochar composite for high-efficiency removal of Pb<sup>2+</sup> and Cd<sup>2+</sup> from aqueous solutions: Unraveling competitive adsorption mechanisms. | The escalating prevalence of heavy metal pollution from lead (Pb<sup>2+</sup>) and cadmium (Cd<sup>2+</sup>) threatens ecological security and public health, necessitating advanced multifunctional adsorbents. Herein, a thiol-functionalized Cu-MOF@biochar composite (SH-MOF@BC) was innovatively synthesized via hydrotherm... |
41652613 | Sustainable nanomaterials for precision dental medicine: green synthesis, therapeutic applications, and future directions. | Sustainable nanomaterials are emerging as transformative platforms for precision dental medicine, uniquely combining environmental responsibility with individualized therapeutic performance. Green-synthesized metallic, polymeric, carbon-based, and bioactive nanomaterials exhibit superior biocompatibility, biodegradabil... |
41652605 | Hydrogel-mediated tri-modal nanoplatform for localized colorectal cancer therapy via smart chemo-photothermal-radiotherapy. | Colorectal cancer (CRC) remains difficult to eradicate locally because chemotherapy, photothermal therapy (PTT), and radiotherapy each have distinct limitations when used alone. Here, we engineer an injectable, mucoadhesive hydrogel-mediated tri-modal nanoplatform designed for localized CRC therapy by integrating smart... |
41652453 | Characterization and functional analysis of N-linked glycosylation on the Hendra virus attachment glycoprotein. | <h4>Background</h4>Hendra virus (HeV) is a bat-adapted zoonotic henipavirus belonging to the Paramyxoviridae family. It is classified as a biosafety level 4 (BSL-4) pathogen owing to its broad host range and high fatality rate. Currently, no vaccines or therapeutics are approved for human use. Viral entry is mediated b... |
41651867 | Novel copper-ion coordinated andrographolide-loaded hydrogel activates Rac1/JNK1 axis for enhancing diabetic wound healing. | Chronic diabetic wounds represent a major clinical challenge, compounded by persistent inflammation, microbial invasion, and deficient angiogenesis. To address these intertwined pathophysiological features, we developed a copper-ion coordinated andrographolide-loaded hydrogel (ASFH), significantly enhancing andrographo... |
41651849 | Urea photosynthesis over a MOF-on-MOF S-scheme heterojunction. | Photocatalytic nitrate reduction reaction coupled carbon dioxide reduction reaction holds great promise for sustainable urea synthesis, the design of photocatalysts with efficient C-N coupling and charge separation is crucial yet challenging. Herein, we report the synthesis of a novel MOF-on-MOF S-scheme heterojunction... |
41651851 | Hierarchical picot-fiber hydrogel coating with ultralow friction and high wear resistance. | Hydrogel coatings are a promising strategy to reduce friction and wear in biomedical implants, yet replicating the durability of natural cartilage remains a key challenge due to the inherent trade-off between low friction and high wear resistance. Here, we present a picot-fiber hydrogel coating (PFHC) that mimics the h... |
41651826 | Tough transparent glass ceramics for multi-mode programmable dynamic tunable persistent luminescence via phase engineering. | Realizing multi-mode programmable dynamic tunable persistent luminescence within a single solid is promising for multi-dimensional information storage and encryption applications. However, coupling luminescent centers with differentiated defect states remains a challenge. Here we report transparent glass ceramics that ... |
41650805 | Improving photodynamic therapy efficacy in bladder cancer using polymer micelle-encapsulated pheophorbide a. | <h4>Background</h4>Photodynamic diagnosis (PDD) is widely used in bladder cancer management, enabling fluorescence-guided detection of lesions through intravesical administration of photosensitizers such as hexaminolevulinate (Cysview®/Hexvix®). Building on this clinical framework, we explored photodynamic therapy (PDT... |
41650386 | Ni(II)-Based Porphyrin-Conjugated Microporous Polymers as Promising Anode for Lithium Storage. | Conjugated microporous polymers (CMPs) have emerged as promising electrode materials for secondary lithium-ion batteries (LIBs), owing to their intrinsic insolubility, structural tunability, permanent porosity, and robust reversibility toward lithium intercalation and deintercalation. However, achieving the simultaneou... |
41650370 | Spatial Confinement of Platinum Nanoclusters in a Photoactive Metal-Organic Framework for Radiotherapy Enhancement and Redox-Mediated Immune Activation. | Tumor resistance to radiotherapy (RT) and immune checkpoint blockade (ICB) is frequently driven by an immunosuppressive tumor microenvironment, where hypoxia and elevated redox buffering impair both cytotoxic and immune responses. Here, we report a new type of metal-organic framework (MOF)-based radiosensitizer, Pt/Hf-... |
41650337 | A Roadmap for Reliable Determination of Aptamer-Target Equilibrium Dissociation Constants (<i>K</i><sub>d</sub>). | Many published aptamer sequences selected and characterized by surface-based methods fail to show quantifiable binding in solution, indicating that their true equilibrium dissociation constants (<i>K</i><sub>d</sub>) are far higher than those originally reported. This discrepancy raises fundamental concerns about the r... |
41650320 | Wafer-Scale All-Dielectric Quasi-BIC Metasurfaces: Bridging High-Throughput Deep-UV Lithography with Nanophotonic Applications. | High quality-factor (Q) dielectric metasurfaces operating in the visible to near-infrared range require sub-200 nm features, limiting fabrication to expensive, low-throughput electron beam lithography. Here, we demonstrate wafer-scale metasurfaces fabricated using deep ultraviolet lithography (DUVL), a workhorse techno... |
41650297 | Ultrasensitive Room-Temperature Detection of Nitrogen Oxides Using Bi<sub>2</sub>S<sub>3</sub> Derived from a Bismuth-Based Metal-Organic Framework. | Nitrogen oxides (NO<sub>X</sub>) pose significant risks to human health and the environment even at low concentrations, which makes their detection at trace levels increasingly important. However, the development of high-performance gas sensors operating at room temperature for monitoring nitrogen oxides (NO<sub>X</sub... |
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