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41595528 | Joint Acidosis and GPR68 Signaling in Osteoarthritis: Implications for Cartilage Gene Regulation. | Joint acidosis is increasingly recognized as an important determinant of cellular behavior in osteoarthritis (OA). Declines in extracellular pH (pHe) occur across cartilage, meniscus, synovium, and subchondral bone, where they influence inflammation, matrix turnover, and pain. Among proton-sensing G protein-coupled rec... |
41591057 | Carbon Dots and Biomimetic Membrane Systems: Mechanistic Interactions and Hybrid Nano-Lipid Platforms. | Carbon dots (CDs) have emerged as a distinct class of fluorescent nanomaterials distinguished by their tunable physicochemical properties, ultrasmall size, exceptional photoluminescence, versatile surface chemistry, high biocompatibility, and chemical stability, positioning them as promising candidates for biomedical a... |
41590745 | Design and Synthesis of Marine Sarocladione Derivatives with Potential Anticancer Activity. | The discovery of structurally novel anti-tumor agents remains a crucial objective in cancer drug research. In this study, we systematically explored the bioactivity potential of sarocladione (<b>5</b>), a structurally unique marine-derived 14-membered ring diketone steroid. Guided by a function-oriented strategy, seven... |
41579646 | Innovative dual-oxidase nanozyme sensor array for rapid detection of tetracyclines in animal-derived foods. | Tetracycline antibiotics (TCs), a class of broad-spectrum antibacterial agents, are frequently detected as residues in animal-derived foods, posing a significant food safety risk. Long-term intake of TC residues can induce antimicrobial resistance, trigger allergic reactions, and cause direct toxicity, compromising hum... |
41576433 | The intelligent nanoreactor ignites mitochondrial homeostasis disruption via calcium overload and ROS storm for the treatment and visual diagnosis of lung adenocarcinoma. | Disrupting mitochondrial homeostasis offers a promising strategy for treating lung adenocarcinoma (LUAD). However, its efficacy is limited by insufficient reactive oxygen species (ROS) generation and calcium ion accumulation. To amplify mitochondrial homeostasis disruption, the thermo/acid-responsive CaAuMn-capsaicin@P... |
41574218 | Mesoporous silica nanoparticles in glioblastoma: smart nano-platforms for targeted therapy and precision diagnosis. | Glioblastoma multiforme (GBM) is a highly aggressive type of brain cancer known for its rapid progression and treatment resistance, presenting significant challenges for effective management. This article examines the promising potential of mesoporous silica nanoparticles (MSNs) as a groundbreaking platform for both th... |
41571224 | The implementation of small molecule agonists and antagonists to elucidate gonadotropin receptor structure, function and physiology. | Pursuant to patient desires of alternatives to injectable gonadotropins, a plethora of attempts have identified, characterized, and demonstrated efficacy of small molecules that activate (agonists) gonadotropin receptors. Discoveries have also been made of small molecule gonadotropin receptor inhibitors (antagonists), ... |
41571140 | Minimizing systemic toxicity of doxorubicin via targeted delivery of hypoxia-sensitive polymersomes. | Hypoxia is a hallmark of solid tumors that reduces chemotherapy efficacy and enhances systemic toxicity. This study evaluated hypoxia-sensitive polymersomes as a delivery system for doxorubicin (DOX) to improve antitumor efficacy and reduce side effects. Methods: Polymersomes were synthesized, loaded with DOX, and test... |
41571121 | Inhibition of Phytophthora infestans chitin synthase via cyclic peptide targeting for sustainable disease control. | Phytophthora spp. are devastating plant pathogens causing significant economic losses in agriculture, but unlike true fungi, oomycetes have cell walls composed predominantly of cellulose and glucans, with little to no detectable chitin. Despite this, one to two putative chitin synthase (Chs) genes are present in Phytop... |
41571112 | Transforming bioresources for high-efficiency energy storage: Utilizing porous carbon derived from reed in supercapacitor applications. | By employing a sol-gel assisted self-assembly strategy to deconstruct the wood fiber structure in reed and subsequently combining it with zeolitic imidazolate framework (ZIF) topology, the in situ composite (N-R<sub>Gel</sub>-ZT) was achieved at the molecular level, thereby producing a N/O co-doped porous carbon via tw... |
41571109 | Lignin nanoparticle-reinforced starch aerogel: eco-designed adsorbent for water remediation. | This study presents an eco-designed strategy for lignin valorization. The approach reinforces starch-based aerogels (SA) with lignin nanoparticles (NLP) produced via disc ultra-refining. NLP enhances interfacial interactions by forming strong hydrogen bonds with the starch matrix. Characterization shows that nanostruct... |
41570980 | Modelling G protein-biased agonism using GLP-1 receptor C-terminal mutations. | <h4>Background and aim</h4>The glucagon-like peptide-1 receptor (GLP-1R) is a major therapeutic target for type 2 diabetes and obesity. Agonists showing bias in favour of G protein signalling over β-arrestin recruitment and GLP-1R internalisation, e.g. tirzepatide and orforglipron, have favourable clinical efficacy pro... |
41570979 | Boosting luteolin bioavailability via P-glycoprotein efflux inhibition: a self-microemulsifying drug delivery systems. | <h4>Introduction</h4>The poor bioavailability of luteolin, a potent flavonoid with antioxidant and anti-inflammatory properties, hinders its therapeutic potential. The primary barriers to its absorption are its low solubility and active efflux by P-glycoprotein (P-gp) in the gastrointestinal tract.<h4>Objectives</h4>To... |
41570921 | Paradoxical G-quadruplex distribution in coronavirus genomes reveals functional constraints and antiviral therapeutic opportunities. | We computationally characterized G-quadruplex (G4) distributions across 31 coronavirus genomes to identify conserved structural features as potential antiviral therapeutic targets. Through an integrated approach combining consensus G4 detection, dinucleotide-preserving null models, and pooled Poisson rate ratios, we id... |
41568220 | Comprehensive characterization and RSM-based optimization of crystal violet adsorption using SnCl<sub>2</sub>-FeCl<sub>3</sub> and SnCl<sub>2</sub>-ZnCl<sub>2</sub> activated pomegranate peel biosorbents. | This study investigates the potential of modified pomegranate peel biosorbents, specifically those activated with SnCl<sub>2</sub>-FeCl<sub>3</sub> and SnCl<sub>2</sub>-ZnCl<sub>2</sub>, for the efficient removal of crystal violet (CV) dye from synthetic wastewater. The physicochemical properties of the prepared materi... |
41568217 | Systematic evaluation of a novel mesoporous silica nanoparticles (MSNs)-<i>Spirulina platensis</i> nanohybrid for breast cancer treatment: mechanistic investigation <i>via</i> pharmacological network analysis. | Breast cancer continues to be one of the world's most deadly diseases among women, with a high incidence rate. Thus, searching for safe and effective treatment is urgently needed. <i>Spirulina platensis</i>, which is packed with an astonishing variety of bioactive compounds, may present a decent option against this cri... |
41568208 | One-pot green synthesis of rGO/SnO<sub>2</sub> nanocomposites from cellulose and SnCl<sub>2</sub> as Lewis acid catalyst. | The development of sustainable, single-step protocols for fabricating metal oxide-graphene heterostructures remains a critical challenge to overcome the toxicity and complexity of conventional synthesis methods. In this regard, this paper reports a one-pot, cellulose-based hydrothermal route for obtaining reduced graph... |
41564744 | A critical and updated review on advanced oxidation processes for micropollutants in aquatic systems: Insights into metal-organic frameworks, mixed metal oxides, effluent toxicity, and cost. | Micropollutants (MPs), such as pharmaceuticals, pesticides, endocrine disruptors, dyes, and industrial chemicals, persist through conventional wastewater treatment, necessitating advanced oxidation processes (AOPs) that can generate high-valence radicals (OH, SO<sub>4</sub><sup>-</sup>, Cl). This review provides an upd... |
41560333 | Regulating Electronic Structure and Confinement-Induced Site Densification in Defective MOF for Boosted Polysulfide Catalysis in Lithium-Sulfur Batteries. | Lithium-sulfur batteries are poised as next-generation energy storage systems but remain constrained by sluggish redox kinetics and severe polysulfide shuttling. The liquid-solid Li<sub>2</sub>S<sub>4</sub>-to-Li<sub>2</sub>S conversion governs the reaction rate, underscoring the importance of electrocatalysts in accel... |
41560311 | Cell-Free DNA-Based Theranostics for Inflammatory Disorders. | Inflammatory disorders are characterized by immune-mediated inflammatory cascades that can affect multiple organs. Cell-free DNA (cfDNA) is not only a biomarker for various inflammatory diseases, but also a driver in innate immune responses, offering emerging diagnostic and therapeutic possibilities for inflammatory di... |
41560329 | Substituent-Based Modulation of Self-Assembly and Immunogenicity of Amphipathic Peptides. | Self-assembled peptide-based biomaterials provide versatile platforms for biomedical uses, featuring customizable physicochemical properties, biocompatibility, and dynamic capabilities. This self-assembly process is primarily dictated by primary sequence features, such as hydrophobicity, length, and charge, leading to ... |
41560305 | A Programmable Nanoreactor Orchestrates Cascade of DNA Sensing to Amplify cGAS-STING Activation for Cancer Immunotherapy. | The cGAS-STING pathway, a critical cytosolic DNA-sensing mechanism in innate immunity, holds significant promise for cancer immunotherapy. However, conventional DNA-damaging therapies lack tumor specificity and cause damage to normal tissue. Furthermore, dendritic cells (DCs), central to the STING-mediated immune respo... |
41559935 | 2D MOF with Intrinsic Porosity for Colorimetric Volatile Organic Compounds (VOCs) Detection. | In this work, we report an uncommon 2D metal-organic framework (MOF) with intrinsic in-plane porosity that undergoes a distinct and reversible colour change upon exposure to various volatile organic compounds (VOCs). The presence of channels oriented parallel to the layers ensures permanent porosity that is preserved e... |
41559892 | Synthesis of the Proposed Structure of Celacarfurine and Analogues Using Sequential Cascade Ring Expansion Reactions. | The first synthesis of the proposed structure of spermidine derived macrocyclic alkaloid celacarfurine is described. A versatile synthetic strategy has been developed based on sequential cascade ring expansion reactions, with high dilution conditions not needed for any of the steps. The same general strategy was also u... |
41559718 | Adamantane-thiazole hybrids and related derivatives: synthesis, crystal structures, in vitro antibacterial, antifungal, and anti-proliferative activities. | Series of 2-(adamantan-2-ylidene)-N-substituted hydrazine-1-carbothioamide derivatives 5a-d and (E)-2-[(adamantan-2-ylidene)hydrazono]-3,4-diaryl-2,3-dihydrothiazole derivatives 7a-l were prepared and their structures were confirmed. In vitro antimicrobial evaluation of compounds 5a-d and 7a-l against different pathoge... |
41559536 | Mapping Optical Chirality with Single Fluorescent Molecules. | Single fluorescent molecules, acting as ideal point dipoles, offer a unique means to probe light-matter interactions at the nanoscale. Here, we exploit this property to map the chiral and vectorial structure of tightly focused optical fields using individual, immobilized terrylene diimide molecules. By scanning the exc... |
41559483 | Template-assisted synthesis of pH-responsive hollow mesoporous silica nanocarriers: the role of engineered pores and surface characteristics. | Hollow silica nanoparticles (HSNPs), characterized by a hollow interior enclosed within a solid mesoporous silica shell, offer several advantages, including low density, high surface area, excellent adsorption capacity, and biocompatibility, making them highly attractive for diverse applications in fields such as food,... |
41559419 | Organic crystalline nanoparticles with a long-lived charge-separated state for efficient photocatalytic hydrogen production. | Photocatalysis offers a promising approach for renewable energy conversion and storage, but short lifetimes of charge-separated states in photocatalysts due to charge recombination limit its utility. Here we report an organic molecule with an acceptor-donor-acceptor configuration that can self assemble into highly crys... |
41559367 | Exercise training mitigates age-related cognitive decline by attenuating TMAO-induced inflammation. | The metabolites produced by the gut microbiota play a role in age-related cognitive decline through the gut-brain axis. Within this axis, trimethylamine N-oxide (TMAO) permeates the intestinal epithelial barrier and enters systemic circulation, triggering inflammation in the central nervous system and ultimately leadin... |
41559265 | Glycophagy is an ancient bilaterian pathway supporting metabolic adaptation through STBD1 structural evolution. | Glycophagy, a selective form of autophagy critical for glycogen homeostasis, relies on the glycogen cargo receptor called starch-binding domain-containing protein 1 (STBD1), yet its evolutionary origins remain elusive. Here, we provide evidence that the Pacific oyster Crassostrea gigas utilizes glycophagy to manage gly... |
41559260 | In silico design and immunoinformatics assessment of a multiepitope vaccine targeting borealpox virus. | Borealpox virus is an emerging zoonotic pathogen with rising global prevalence and no approved vaccines or targeted treatments. This study aimed to design a multi-epitope subunit vaccine against Borealpox virus. The viral cell-surface binding protein was selected as the primary antigenic target due to its role in host-... |
41559129 | Synthesis, characterisation and evaluation of polyethylene glycol-β-cyclodextrin-curcumin-zinc oxide nanoparticles for mosquitocidal, antibacterial and anticancer applications. | To synthesise and characterise polyethylene glycol-β-cyclodextrin-curcumin-zinc oxide nanoparticles (PEG-Beta-Cur-ZnO NPs) and evaluate their stability, anti-mosquitocidal, antibacterial, and anticancer activities for potential biomedical and vector-control applications. Characterisation was performed using UV-Vis spec... |
41559114 | Removal of fluoride from groundwater using a zeolite A supported magnetite biochar composite. | Prolonged consumption of excess fluoride concentration (> 1.5 mg/L) from groundwater notably poses serious health effects, including dental and skeletal fluorosis in the Rift Valley area of Ethiopia. In this study, a zeolite A supported magnetite biochar composite (Z-A/M-BC) was synthesized through a pyrolysis method f... |
41559096 | Glycine photosynthesis via C-N coupling of waste plastic and nitrate over diatomic Pd-B catalyst. | Photocatalytic C-N coupling offers a promising approach for the sustainable production of amino acids, but the uncontrolled coupling pathway of reaction intermediates limits yield and selectivity. This paper describes a Pd-B diatomic catalyst that can selectively catalyze the photosynthesis of glycine via C-N coupling ... |
41559095 | Natural deep eutectic solvents as a sustainable alternative for multi-class pesticide extraction in food safety analysis. | Pesticide residue analysis in food is frequently carried out worldwide, often requiring a large volume of organic solvents. To improve sustainability, new generation solvents such as natural deep eutectic solvents (NADES) have recently emerged as a promising alternative to conventional solvents. This study demonstrates... |
41559049 | Near-100% site utilization of single atoms for efficient electrocatalysis. | Despite that enhancing site utilization (U<sub>site</sub>) of single atoms (SAs) is crucial in electrocatalysis beyond increasing intrinsic activity and site density, numerous SAs are inaccessible during reaction due to the dense micropores and disordered stacking of carbon particles. Here, the enhancement for U<sub>si... |
41559043 | Intermittent fasting inhibits Tp53-driven glioma through gut microbiota-mediated methionine-m<sup>6</sup>A regulation. | Intermittent fasting (IF) has emerged as a potential cancer treatment modality, although its tumor-suppressive effects are limited. Glioblastoma (GBM) can be classified into CDKN2A subtype and TP53 subtype. Here, we discover that the efficacy of IF is correlated with tumor subtypes of GBM. IF significantly inhibite GBM... |
41559027 | Non-traditional fluorescence in quadruple hydrogen bonded supramolecular polymers. | Non-traditional luminescent polymers exhibit significant advantages in bio-diagnostics and intelligent materials but suffer from low luminescence efficiency and limited functionality. Inspired by the excited-state proton transfer mechanism mediated by dense hydrogen bonds in jellyfish fluorescent proteins, we propose a... |
41559040 | High-spin state dynamics and quintet-mediated emission in intramolecular singlet fission. | High-spin states in molecular systems hold significant interest for applications ranging from optoelectronics to quantum technologies. Spin states generated in intramolecular singlet fission are of particular relevance, yet the mechanisms controlling triplet-pair formation are not fully understood - especially the invo... |
41558996 | Allosteric Regulation of RNA Affinity by Motif V-VI Coupling in West Nile Virus NS3 Helicase. | The rise of flaviviral diseases, including West Nile virus (WNV), presents a growing threat to global public health and underscores the urgent need for new therapeutic strategies. The non-structural protein 3 helicase (NS3h) of the Orthoflavivirus genus, including WNV, is essential for viral replication and a promising... |
41558979 | Highly Conductive Flexible Electrode Based on Liquid Metal@MOF Coated Hydrogel for Muscle and Multi-Scenario Heart Signal Monitoring. | The mechanical stability of flexible electronic materials and their adaptability to diverse application scenarios constitute key bottlenecks limiting their practical deployment. To overcome these challenges, this study presents an innovative strategy for fabricating liquid metal composites by enabling efficient integra... |
41558674 | AFM-Based Single-Molecule Force Spectroscopy of PEG-Anti-PEG Antibody Interactions. | Poly(ethylene glycol) (PEG) is widely used as a stealth polymer to enhance drug stability and circulation by reducing immune recognition. However, anti-PEG antibodies are increasingly reported in humans, leading to accelerated drug clearance and adverse immune responses. While ensemble assays have clarified the scheme ... |
41557966 | Substituent Size and Interaction Type Shape Sulfonylurea-β-Cyclodextrin Binding Modes. | Sulfonylureas are hypoglycemic agents used in type 2 diabetes mellitus, although their low water solubility implies high therapeutic doses. Inclusion complexes with β-cyclodextrin (β-CD), a cyclic oligosaccharide featuring a hydrophobic interior and hydrophilic exterior, offer a supramolecular polymer capable of encaps... |
41557945 | Preclinical Safety Evaluation of BB106, a Novel Ketamine-Sulfobutylether-Beta-Cyclodextrin Salt, Following Subcutaneous Administration in Rats and Göttingen Minipigs. | BackgroundConventional ketamine hydrochloride solutions are acidic and hyperosmotic, limiting their tolerability for subcutaneous (SC) delivery. BB106 is a novel ketamine formulation using the multitude of sulfobutylether-beta-cyclodextrin (SBECD) anionic substitutions as ionic counterions to achieve a new ketamine-SBE... |
41557944 | Electron-Deficient Confined Space: Synthesis and Recognition Properties of a Covalent Molecular Cage Built upon Naphthalene Diimides and Benzene Triimides. | The synthesis of neutral-electron-deficient molecular containers is highly challenging. Nonetheless, the presence of π-acidic units within the confined space of a molecular cage should enable strong anion binding through synergistic anion-π interactions. Here, we report the synthesis of a neutral molecular cage contain... |
41557883 | Near-Infrared Light-Inducible CRISPR-Cas12a/Tetrahedral DNA Nanosystem for Spatiotemporal Control of mtDNA Mutation Imaging and Gene Therapy. | Mitochondrial DNA (mtDNA) mutations are associated with tumor progression and metabolic dysregulation, yet their spatiotemporal visualization and selective therapeutic modulation remain challenging owing to their low abundance and mitochondrial double-membrane barrier. We report a near-infrared (NIR) light-inducible CR... |
41557877 | RNA Resolution in an Electric Double Layer Generated by Metal-Organic Frameworks. | The interaction between metal-organic frameworks (MOFs) and nucleic acids offers significant potential for smart biosensing platforms. However, the underlying mechanisms remain elusive, limiting their practical implementation. Herein, we unveil the critical role of the electric double layer (EDL) at the MOF-solution in... |
41557833 | Luminescent Lanthanide Metal-Organic Frameworks for Temperature Sensing in Two Distinct Temperature Regions. | Luminescent ratiometric temperature sensors based on lanthanide(III) (Ln<sup>3+</sup>) metal-organic frameworks (LnMOFs) have emerged as promising materials in nanothermometry due to their hybrid nature and unique photophysical and structural properties. These include high chromophore density and well-defined, robust c... |
41557795 | Sleep loss induces cholesterol-associated myelin dysfunction. | The increasing prevalence of sleep deprivation poses a public health challenge in modern society. Manifestations of reduced alertness, such as slowed reaction times and increased errors, are well-documented behavioral indicators of sleep loss (SL). Yet, the biological consequences of sleep deprivation and their role in... |
41557749 | The receptor binding properties of H5Ny influenza A viruses have evolved to bind to avian-type mucin-like O-glycans. | Highly pathogenic H5Ny influenza A viruses are causing unprecedented, season-independent outbreaks across avian and mammalian species, including dairy cattle, a novel reservoir. The sialoside-binding properties of influenza A hemagglutinin (HA) are strongly related to its ability to infect and transmit between hosts. M... |
41557731 | The Oxylipin Dependent Quorum Sensing System enhances Pseudomonas aeruginosa dissemination during burn-associated infection. | Pseudomonas aeruginosa is a leading cause of life-threatening infections in burn patients, yet the molecular cues driving its hypervirulence remain poorly understood. Here, we identify the Oxylipin Dependent Quorum Sensing (ODS) system as a key regulator of P. aeruginosa pathogenicity in the burn wound environment. Usi... |
41557688 | Cell death-related gene signatures as dual-function biomarkers: Early diagnosis and therapeutic targeting in Staphylococcus aureus pneumonia. | <h4>Background</h4>Staphylococcus aureus (S. aureus) pneumonia constitutes a lethal respiratory infection with persistently high clinical mortality. Although programmed cell death (PCD) pathways are implicated in diverse disease processes, their mechanistic roles in S. aureus pneumonia pathogenesis, particularly as dua... |
41557635 | Zwitterionic molecularly imprinted polymers for selective capillary microextraction of N1,N12-Diacetylspermine (DiAcSpm) from breast cancer. | N1,N12-diacetylspermine (DiAcSpm), a promising biomarker for cancer diagnosis, presents significant quantification challenges due to the structural homology within the polyamine family. To address this issue, we engineered a molecularly imprinted monolithic (MIM) column functionalized with biomimetic phosphorylcholine ... |
41557627 | Elucidate senescence-related gene signature and immune infiltration landscape in abdominal aortic aneurysm. | <h4>Background</h4>Abdominal aortic aneurysm (AAA) refers to a lasting enlargement of the abdominal aorta. Senescence, a major risk factor of AAA, demonstrate positive connection with both the formation and rupture of aneurysms. Therefore, investigating the underlying pathogenic mechanisms of senescence in AAA and expl... |
41557537 | Mesoporous Materials for Electrochemical Biosensors: From Broad Structure to Silica Film. | Mesoporous materials, characterized by tunable pore structures, large surface areas, and versatile surface properties, have become essential for advancing electrochemical biosensors. Their unique structural features enable efficient immobilization of biomolecules, enhancing electron transfer and amplifying signal trans... |
41557508 | Structural Dynamics of Peptiplexes Formed between Cationic Cell-Penetrating Peptides and DNA: A Comparative Study on TAT-HIV and NLS-SV40T. | Biomembranes evolved to protect cells and regulate exchange, forming a powerful barrier to large, charged macromolecules such as nucleic acids. In recent years, this paradigm has been competently overturned by soft biomaterials based on cell-penetrating peptides (CPPs). Herein, we investigate and compare the structural... |
41557480 | Diastereomeric Branched-Ester dBET1 Analogs Exhibit Conformation-Dependent Differences in Passive Membrane Permeability. | Proteolysis-targeting chimeras (PROTACs) represent a promising therapeutic modality, but their clinical translation is often hindered by poor pharmacokinetic properties associated with their location in the "beyond Rule of 5" chemical space. Using the BRD4 degrader dBET1 as a model, this study explored a dual approach ... |
41556844 | Coelectrolysis of PET and CO<sub>2</sub> Using an Electrochemically Restructured Co-MOF-74 Anode and a Polymeric Co-Phthalocyanine Cathode. | Mitigating carbon emissions and plastic waste is a pressing societal challenge due to the disruptive environmental impact of incremental accumulation. A promising strategy to address both issues is coelectrolysis of CO<sub>2</sub> and PET-plastic waste to high-value commodity chemicals. Here, we report electrocatalytic... |
41556775 | Selective Catalytic Styrene Dimerization through the Combined Action of a Strong Sn(IV)-Porphyrin Lewis Acid and a Weak Brønsted Base. | Complexes of the form Sn(TPP)X<sub>2</sub> (where TPP<sup>2-</sup> = tetraphenylporphyrinate and X<sup>-</sup> = Cl<sup>-</sup>, OTf<sup>-</sup>, ClO<sub>4</sub><sup>-</sup>, and NTf<sub>2</sub><sup>-</sup>) were investigated as catalysts for the activation of the nonpolar C═C bond of styrene. Sn(TPP)(OTf)<sub>2</sub> ... |
41556568 | Mini-Hairpin DNA: Extraordinarily Stable Structure and Its Applications. | Nucleic acids exhibit diverse biological functions through hierarchical structural organization, and higher-order architectures enable recognition beyond Watson-Crick base pairing. Here, we describe the discovery and characterization of an unusual, extraordinarily stable motif-mini-hairpin DNA-a compact hairpin structu... |
41556548 | Rigid-Flexible Layered Immobilization Enables Precise Confinement and Dynamic Activation of Small Enzymes. | Small enzymes (10-50 kDa) encounter challenges of unstable enzyme-carrier interactions and low activity retention during immobilization, with existing strategies lacking specificity. Unlike previous industrial enzyme-focused studies, a rigid-flexible layered immobilization strategy integrating networked metal-organic f... |
41556485 | Self-Driven Interfacial Assembly of MIL-68 MOFs on Group-III Nitride Nanorod Arrays for Constructing Efficient Photoanodes. | The development of highly efficient and stable photoelectrochemical (PEC) systems remains a critical challenge for solar-driven water splitting and pollutant degradation. Herein, a novel strategy is reported for the self-driven interfacial assembly of MIL-68-type metal-organic frameworks (MOFs) on group III-nitride nan... |
41556460 | Redox and Spin States Series of an Organometallic Heme Analogue Based on a Non-Innocent NHC/N-Donor Hybrid Macrocycle. | Iron complexes of tetradentate macrocyclic ligands containing <i>N</i>-heterocyclic carbene (NHC) donors have been referred to as organometallic heme analogues, but they usually lack the redox noninnocence under oxidizing conditions that is characteristic of porphyrins. Here we report a novel NHC/N-donor hybrid macrocy... |
41556451 | Upconverted Hot Electrons and Solvated Electrons from Mn-Doped Semiconductor Nanocrystals for Photochemistry: Perspective. | Hot electrons photogenerated in semiconductor nanocrystals enable powerful redox reactivity due to their large excess energy and their capability for long-range transfer over high energy barriers. Among various strategies for hot electron generation, Mn-mediated Auger upconversion in Mn-doped semiconductor nanocrystals... |
41556425 | Urea-Formaldehyde Resin Confined Silicon Nanodots Composites: High-Performance and Ultralong Persistent Luminescence for Dynamic AI Information Encryption. | Persistent luminescence materials typically encounter an intrinsic trade-off between high phosphorescence quantum yield (PhQY) and ultralong phosphorescence lifetime. To overcome this limitation, we propose a strategy that immobilizes silicon nanodots (SiNDs) within a dual-functional composite matrix. The SiNDs efficie... |
41556412 | Intrinsically Chiral Excimers: Water-Compatible Trityl-Based Nanoparticles as Tailored Dual Emitters of Circularly Polarized Luminescence in the Vis or NIR Regions. | Circularly polarized light is characterized by the rotation of theelectric field vector in a clockwise or counterclockwise direction as it propagates, enabling the transmission of information through two independent channels. This property facilitates advances in communication technologies, sensing, bioimaging, and med... |
41556410 | Structural and Mechanical Dynamics of Polymer Membranes Across Multilength Scales. | Understanding the mechanical and structural evolution of polymer membranes under heat and strain is important for many applications. Conventional techniques, such as dynamic mechanical analysis provide bulk mechanical information but lack the spatial resolution to capture localized variations. Similarly, X-ray diffract... |
41556409 | Adjunctive Therapies in Periodontitis: Current Concepts and the Future. | Periodontitis is a chronic, host-mediated inflammatory disease in which microbial dysbiosis and dysregulated immune responses drive the destruction of tooth-supporting tissues. Although conventional therapy remains centered on mechanical biofilm control, persistent inflammation and alveolar bone loss in susceptible ind... |
41556405 | Biomimetic Iridium-Based Photothermal Nanozyme to Trigger Ferroptosis and Pyroptosis and Activate the cGAS-STING Pathway for Improved Tumor Immunotherapy. | Although nanozymes are potential tumor therapeutics due to their ability to disrupt intracellular redox homeostasis, developing nanozymes with higher therapeutic efficacy and clarifying their antitumor mechanism are challenging. Here, an iridium (Ir)-based nanozyme (IIN) was constructed through coordination-driven co-a... |
41556383 | Boosting the Nucleophilicity of the Diphenylphosphide Anion with Crown Ether Supported Heavy Alkali Metals to Facilitate Highly Efficient Catalytic Alkene Isomerisation. | Caesium and rubidium have long experienced an interest drought in organoelement chemistry in comparison to the vast ocean of applications accomplished mainly by lithium and to a lesser extent, by sodium and potassium in this field. Here, we report a breakthrough study in catalytic alkene isomerisation using crown ether... |
41556379 | Photothermal-Immunomodulatory Hydrogel Reinforced by Ti<sub>3</sub>C<sub>2</sub>/ZnAl-LDH Nanoplatform for Eradicating MRSA and Promoting Diabetic Wound Healing. | MRSA infections give rise to chronic cutaneous and advance into profound tissue invasions, including osteomyelitis and sepsis-conditions for which existing clinical interventions offer only limited efficacy. The utility of broad-spectrum antibiotics has become increasingly compromised by escalating drug resistance, ina... |
41556366 | Crystal Engineering on Cu-Triazolate MOFs via Mixed-Linker Modulation for Selective Azeotropic Ethanol Dehydration. | A mixed-linker synthetic strategy was employed to engineer the morphology of copper-triazolate metal-organic frameworks (Cu-Tz MOFs) through controlled crystal growth. By incorporating amino- and thioether-functionalized triazole alongside the parent triazole linkers, the framework's hydrophilicity, pore cavity, and su... |
41556264 | Synergistic Tuning of Conformational Dynamics, Electron Tunneling, and Substrate Positioning Enhances Electron Transfer in a P450 Chimera for Calcifediol Biosynthesis. | Electron transfer (ET) efficiency dictates catalytic performance in multi-domain self-sufficient cytochrome P450s. Conventional engineering, however, predominantly focuses on localized optimization of either the active-site pocket or linker regions, overlooking inter-domain conformational transitions and ET chain integ... |
41556250 | Engineered CAR-NKT Extracellular Vesicles Suppress Tumor Progression and Enhance Antitumor Immunity. | Chimeric antigen receptor-engineered natural killer T (CAR-NKT) cell therapy represents a promising and innovative strategy in cancer immunotherapy, but is limited by acute toxicity and adverse effects, restricting broader clinical application despite durable responses. In this study, a novel nanobody targeting TM4SF1 ... |
41556233 | Structural and Biophysical Characterization of the Yersinia Type Three Secretion System ATPase YscN. | Yersinia pestis was responsible for the Black Plague, one of the worst epidemiological disasters in recorded history. Today, Y. pestis, Y. enterocolitica, and Y. pseudotuberculosis remain clinically relevant human pathogens. Each of these pathogenic Yersinia species relies on a Type Three Secretion System (T3SS) for vi... |
41556173 | Ultrasound-mediated targeted micro/nanobubbles: breaking new boundaries in precision tumor therapy. | Malignant tumors pose a public health challenge due to escalating incidence and mortality. Traditional treatments suffer from poor target specificity between healthy and tumor tissues, resulting in severe side effects. Immunotherapy is a pivotal advancement, but it faces poor tumor penetration, low targeting efficiency... |
41556090 | Alkaline Phosphatase-Activated NIR-II AIEgens Nanosystem for Surgical and Postoperative Closed-Loop Therapy of Advanced Osteosarcoma. | In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's immunosuppressive nature, making residual lesions a key source of recurrence. To address this, we developed an ALP-responsive theranostic nanoplatform (SGPF) integrating an AIEgens (STEA) and HSP90 in... |
41555463 | Advancing cellulose degradation through synthetic biology: engineered pathways and microbial systems for sustainable biomass conversion. | Fiber, the most abundant organic polymer in nature, is widely recognized as a foundational sustainable material with diverse applications across industrial, medical, and consumer domains. Owing to its renewability and widespread availability, it also serves as a critical alternative energy source in agriculture, enabli... |
41554724 | Operando nuclear magnetic resonance decodes alkali-tuned proton-electron relay boosting CO<sub>2</sub>-to-formate conversion. | The proton-coupled electron transfer (PCET) kinetics plays a critical role in governing the CO<sub>2</sub>-to-formate conversion efficiency during CO<sub>2</sub> eletroreduction reaction. While alkali metal cations are known to influence the reaction pathway, elucidating how trace doping modifies the catalytic sites re... |
41554708 | A versatile coherent Ising computing platform. | Coherent Ising machines (CIMs) have emerged as a hybrid form of quantum computing devices designed to solve NP-complete problems, offering an exciting opportunity for discovering optimal solutions. Despite challenges such as susceptibility to noise-induced local minima, we achieved notable advantages in improving the c... |
41524675 | Ostwald ripening-induced hollow photoactive Zn-MOF-confined electron-deficient Cu NPs for enhanced photocatalytic oxidative dehydrogenation to quinoline. | A well-defined hollow Cu/Zn-TPBD composite was constructed for the first time <i>via</i> a modified Ostwald ripening method in this study. The unique donor-acceptor architecture in Cu/Zn-TPBD induced enhanced charge separation efficiency compared to parent Zn-TPBD, enabling superior optoelectronic properties and reacti... |
41504324 | Efficient separation of CH<sub>4</sub>/C<sub>2</sub>H<sub>6</sub>/C<sub>3</sub>H<sub>8</sub> enabled by an indium-tetracarboxylate MOF with cross-channel and amino sites. | The highly efficient purification of CH<sub>4</sub> from natural gas is critical for energy applications but remains a major separation challenge. Porous frameworks featuring high adsorption performance for C<sub>3</sub>H<sub>8</sub> and C<sub>2</sub>H<sub>6</sub> over CH<sub>4</sub> offer a promising approach. Herein,... |
41437922 | Discrete and polymeric supramolecular complexes assembled from Cu<sup>2+</sup> and isomeric xylylenebis(pyridyltriazoles). | The coordination chemistry of Cu<sup>2+</sup> with three isomeric xylylene-bridged bis-chelating pyridyltriazole ligands (<i>o</i>-xpt, <i>m</i>-xpt, and <i>p</i>-xpt) is systematically explored. These ligands were chosen for their ability to form <i>trans</i>-planar chelating coordination modes, in contrast to the com... |
41384767 | Therapeutic extracellular vesicle preparation <i>via</i> sequential electrophoretic enrichment and counterflow microdialysis. | A microfluidic platform designed to enhance the development of extracellular vesicle (EV)-based therapeutics is presented. The two-chip system combines rapid electrokinetic concentration and purification of EVs together with counterflow buffer exchange to prepare the purified vesicles for pH gradient-driven drug loadin... |
41288431 | Strategies for improving oxygen evolution performance of MOF nanoarrays. | The design of efficient electrocatalysts for the oxygen evolution reaction (OER) is crucial for addressing global energy challenges, yet remains a significant scientific hurdle. Metal-organic frameworks (MOFs) have emerged as particularly promising OER catalysts due to their unique structural advantages, including well... |
41283742 | A journey through metallophilic interactions: computational approaches and insights. | Metallophilic interactions, defined as counterintuitive weak attraction between closed-shell metal cations, are essential for stabilizing molecular and solid-state structures, driving supramolecular assemblies or designing functional materials. Despite over half a century of intensive study, the physical origin of meta... |
41909611 | AGGRESCAN and its evolution: A two-decade perspective on protein aggregation prediction. | Protein aggregation is a widespread phenomenon with profound biological, biomedical, and biotechnological implications. In human disease, aberrant protein self-assembly is a hallmark of numerous neurodegenerative disorders, whereas in the biopharmaceutical industry, aggregation complicates the production, stability, an... |
41907097 | Development of a 3D In Vitro Model of Dupuytren's Disease as a Platform for Drug Screening. | <h4>Background</h4>Dupuytren's disease (DD) is a common fibrotic disorder of the hand, characterized by progressive thickening and contracture of the palmar and digital fascia. Surgical excision remains the primary treatment; however, there are currently no therapies to prevent disease progression or recurrence. This s... |
41884058 | Multifunctional nanofibrous membranes enhance diabetic wound healing by inhibiting endothelial pyroptosis and regulating macrophage polarization. | <h4>Background</h4>Persistent oxidative stress and aberrant inflammatory responses are major contributors to delayed wound healing in diabetic patients. Endothelial cell pyroptosis, a form of inflammatory programmed cell death, plays a critical role in vascular dysfunction and impaired tissue regeneration in diabetic w... |
41810102 | Tumor Vaccines in Hepatocellular Carcinoma: Advances, Challenges, and the Path Toward Precision Immunotherapy. | Primary hepatocellular carcinoma (HCC) remains one of the leading causes of cancer-related mortality worldwide, with curative options still limited for patients with advanced disease. As an emerging modality of cancer immunotherapy, tumor vaccines represent a promising approach that activates the host immune system to ... |
41800217 | A guide to selecting high-performing antibodies for Alpha-1-antitrypsin (UniProt ID: P01009) for use in western blot, immunoprecipitation and flow cytometry. | Alpha-1-antitrypsin (A1AT), encoded by the <i>SERPINA1</i> gene, is a circulating serine protease inhibitor that protects the lung from neutrophil elastase-mediated tissue damage. Mutations in <i>SERPINA1</i> cause alpha-1-antitrypsin deficiency, one of the most common hereditary causes of respiratory disease, leading ... |
41788474 | Emerging role of nucleic acid aptamers in sepsis-induced coagulopathy: Future perspectives in diagnostics and therapeutics. | Sepsis-induced coagulopathy is a severe complication of sepsis and septic shock, contributing significantly to organ dysfunction and increased mortality. Currently, there is no effective treatment for coagulopathy, highlighting a critical need for new therapeutic options to improve patient outcomes. This review explore... |
41768291 | A guide to selecting high-performing antibodies for MMP7 (UniProt ID: P09237) for use in western blot and immunoprecipitation. | Matrix metallopeptidase 7 (MMP7, also known as matrilysin) is a secreted zinc-dependent endopeptidase implicated in extracellular matrix remodelling and fibrotic processes. Elevated MMP7 expression is a hallmark of idiopathic pulmonary fibrosis and other interstitial lung diseases, where it has emerged as a candidate b... |
41755854 | Access to Polyethylene-Polyester Block Copolymers in Continuous Flow through Single-Step Chain-End-Functionalized Polyethylene. | Polar polyolefin block copolymer synthesis in continuous flow faces significant challenges due to the nature of the monomers, which require selective polymerization methods for the polymer segments. In this study, we developed a continuous flow strategy by utilizing 2-hydroxyethyl acrylate (HEA) chelated diimine Pd<sup... |
41755841 | Pyracylenes: Facile Synthetic Access and Continuous Face-To-Face Antiaromatic π‑Stacking. | Pyracylene is a nonalternant hydrocarbon which has long fascinated chemists, but whose structure is exceedingly rare in experimental reports. Pyracylene's surprising absence arises from synthetic inaccessibility attributable to its antiaromatic character. Meanwhile, sterically unimpeded polycyclic antiaromatic hydrocar... |
41755823 | Emergence of Radiochromic Metal-Organic Frameworks for Information Encryption via Dual-Stimuli Responses. | Secure information encryption is paramount in modern society for data protection, anticounterfeiting, and confidential communication. Here, we report the first demonstration of radiochromic metal-organic frameworks (MOFs) for high-security information encryption, leveraging their unique X-ray-induced chromic responses.... |
41696028 | Cultivation and genomic characterization of novel methanogens from arid desert biocrust. | Methanogens are strictly anaerobic archaea capable of energy conservation by methane production, yet their presence in oxic and arid environments challenges existing paradigms. In this study, we enriched and genomically characterized seven methanogenic cultures from desert biocrusts, affiliated with the genera <i>Metha... |
41679865 | Synergistic design of ionic liquid monomers and MOF-cellulose scaffolds for selective protein recognition in molecularly imprinted materials. | To address the low binding-site density and mass-transfer limitations of conventional protein-molecularly imprinted polymers (P-MIPs), this study proposes a synergistic strategy combining a custom-synthesized imidazolium ionic liquid monomer, 1-vinyl-3-diacetamidoimidazolium chloride ([VDAIM]Cl), with a bacterial-cellu... |
41675049 | Perspectives on the application of layered MPX<sub>3</sub> materials (M: Transition metal, X: Chalcogen) in confined catalysis and energy applications. | The concept of confined catalysis, where reactions occur within nanoscale environments that modulate reaction energetics, has emerged as a powerful paradigm for designing advanced catalytic systems. Inspired by the efficiency of enzyme active pockets through metal-enzyme cascade reactions, confined architectures provid... |
41660115 | Immediate tumor killing and long-term anti-tumor immunoreaction induced by Bufalin-loaded phototherapeutic Janus membrane in CRC postoperative therapy. | Colorectal cancer (CRC) management is significantly hindered by the challenges of early detection and the high rates of recurrence and metastasis following surgery. Systemic postoperative therapies are frequently compromised by adverse effects and drug resistance. To address this, we engineered a localized and combinat... |
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