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41810472 | The evolution of lipid nanoparticles: Paving the way for next-generation nucleic acid medicines. | Nucleic acid-based therapies have emerged as promising strategies for the regulation of gene expression and the production of therapeutic antigens or proteins for a series of diseases, including cancers, rare diseases, and infectious diseases. However, their clinical application faces challenges. These include high mol... |
41768460 | Rational Design of New Biocompatible Near-Infrared Conjugated Polymer Nanoparticles for Biomedical Applications. | Conjugated polymer nanoparticles (CPNs) have gained significant attention as promising nanomaterials for cancer theranostics, particularly in fluorescence imaging and therapy, where early detection and image-guided surgery are crucial for effective treatment. Despite growing interest, there remains a notable gap in the... |
41768456 | Time-Dependent Structure Assessment of Conjugated Polymer Aggregates in Solution by Single-Molecule Fluorescence Spectroscopy. | Monitoring and understanding the aggregation kinetics of n-type polymers provide strategies to favorably control aggregation and thereby optimize conjugated polymers ink shelf life, printability, and thin-film properties. Here, the in situ characterization of n-type copolymer aggregates employing ensemble absorbance an... |
41765587 | Regulation of phospholipid scramblases by cholesterol. | The activity of membrane proteins is often regulated by their lipid environment, either via physical properties of the membrane or by direct interaction with specific lipids. Testing these effects with purified proteins reconstituted into lipid vesicles is challenging because of the compositional heterogeneity of the v... |
41716732 | Epilepsy Phenotypic Spectrum of NUS1-Related Disorder: A Case Series. | <h4>Background</h4>Epilepsy with myoclonic and atonic seizures (EMAtS), also known as Doose syndrome, accounts for 1%-2% of childhood epilepsies, and various genes have been implicated in causing this epilepsy syndrome. <i>NUS1</i> encodes for Nogo-B receptor (NgBR), which stabilizes the dehydrodolichyl-diphosphate syn... |
41695493 | Engineering a modular FAP-targeting ferritin-based drug nanocarrier for enhanced glioblastoma theranostics. | <b>Rationale:</b> Glioblastoma multiforme (GBM) is an aggressive brain tumor marked by diffuse infiltration, a complex microenvironment, and poor drug delivery due to the blood-brain barrier. Fibroblast activation protein (FAP), widely expressed by cancer-associated fibroblasts (CAFs), emerges as a promising yet undere... |
41695491 | From 2D cultures to 3D systems: evolving cancer models at the interface of functional precision medicine and theranostics. | Advances in patient-derived cancer models are pushing precision oncology by linking functional testing directly to therapeutic decision-making. Traditional two-dimensional (2D) cancer cell culture systems have long served as accessible tools for studying cancer biology and drug responses, but their inability to replica... |
41695485 | Red blood cell-conjugated biomimetic nanomedicine for enhanced therapy of non-small cell lung cancer. | <b>Rationale:</b> Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are a standard therapy for non-small cell lung cancer (NSCLC). Despite their clinical efficacy, dose-limiting systemic toxicity and the eventual development of acquired resistance limit their long-term benefit. Therefore, innovati... |
41691788 | Differential predictive value of FRAX Hip and major osteoporotic fracture probabilities for denosumab response. | <h4>Introduction</h4>The Fracture Risk Assessment Tool (FRAX) estimates 10-year probabilities of major osteoporotic fracture (MOF) and hip fracture. Whether these two components differentially predict response to denosumab remains unclear.<h4>Objectives</h4>To determine whether baseline FRAX-MOF and FRAX-hip probabilit... |
41675675 | A purpurin-based metalloimmunostimulant amplifies ROS and modulates STING/TNF-α axis to potentiate melanoma immunotherapy. | The low infiltration of pro-inflammatory immune cells and the sustained activation of multiple immunosuppressive signaling pathways in melanoma significantly limit the efficacy of clinical immunotherapy. Therefore, developing an effective immunostimulant with reversing the immunosuppressive tumor microenvironment (TME)... |
41660130 | Engineered targeted Ce-based MOF nanozymes for ROS scavenging and inflammatory Reprogramming in chronic pancreatitis. | Chronic pancreatitis (CP) is a lifelong progressive fibrotic inflammatory disorder for which no effective cure is currently available. Persistent and recurrent inflammatory stimulation induced by reactive oxygen species (ROS) is a key driver of pancreatic fibrogenesis, making oxidative stress a promising therapeutic ta... |
41660126 | Advancing precision tumor therapy: Progress in targeted delivery of peptide-based nanomaterials from microenvironment to organelles. | Precisely targeted delivery of antitumor agents is a key strategy for enhancing cancer treatment efficacy. By leveraging specific tumor characteristics, functional modifications can construct highly selective delivery systems to optimize nanomedicine distribution at tumor sites. Owing to their editable sequences, pepti... |
41660114 | A multiscale quantum dots-based material platform for high-performance immunosensing of rhinitis biomarkers. | Rhinitis is a common chronic respiratory disease that severely affects patients' quality of life and may lead to serious complications, underscoring the need for rapid and portable diagnostic tools to support routine monitoring and clinical management. Here, we introduce a multiscale material platform based on colloida... |
41658216 | Integrative Structural Characterization of <i>Candida glabrata</i> Phosphoglycerate Kinase by Small-Angle X‑ray Scattering and AlphaFold: Implications for Therapeutic Targeting in Candidiasis. | <i>Candida glabrata</i> is the second leading cause of mortality in immunocompromised patients hospitalized for invasive candidiasis (IC). Several drugs have been available to treat this disease for decades, such as polyenes, azoles, echinocandins, flucytosine, and, in critical cases, amphotericin B. However, these ant... |
41658177 | Development of Highly Stable Vitamin C Gummies Using Innovative In Situ Soft Sphere Integrated (ISSI) Liposomal Technology: Characterization and In Vitro Release Studies. | Vitamin-enriched gummies are gaining popularity due to their convenience and consumer appeal; however, incorporating water-soluble and unstable vitamins such as vitamin C remains challenging because of its poor stability and rapid degradation during processing. This study aimed to develop a heat-stable liposomal vitami... |
41658127 | Yttrium-Modified B<sub>12</sub>N<sub>12</sub> Nanocages for High-Performance H<sub>2</sub> Sensing: Insights from DFT Calculations on Sensitivity, Selectivity, and Recovery. | Boron nitride (B<sub>12</sub>N<sub>12</sub>) nanocages have attracted considerable attention due to their exceptional structural stability and tunable electronic properties, making them promising candidates for gas-sensing applications. In this study, DFT-D3 calculations at the B3LYP/def2-TZVP level, including relativi... |
41658077 | Smart Bioaerosol Monitoring: Advanced Sampling and Sensing across Environmental, Clinical, and Industrial Domains. | Bioaerosols are microorganisms in the air, such as bacteria, viruses, fungi, or allergens. Their concentration and health risks are increasing due to the current pandemic and rising pollution in cities. They are hard to control and eliminate because of their diversity, fluctuating concentrations, and changing environme... |
41658070 | Poly(styrene-<i>alt</i>-maleic acid)-assisted Membrane Solubilization for Improved Immobilization and Catalytic Performance of Soybean Lipolytic Enzymes in Electrospun Poly(vinyl alcohol) Fibers. | Efficient extraction and stabilization of plant-derived enzymes remain challenging due to their susceptibility to denaturation during processing. Soybean lipases, while exhibiting intrinsically high activity, lose functionality rapidly in the presence of salts, organic solvents, or elevated temperatures, thereby limiti... |
41657718 | Colloidal and membrane stabilization of nanoproliposomes coated with chitosan-alginate polymers: Thermal properties, gastrointestinal release and reconstitutability. | Instability, leakage and unwanted release of bioactive compounds loaded into nanoliposomes (NLs) are among the key challenges during storage, formulation, or various tensions (mechanical, thermal, shear, etc.). In this study, lipid membrane stabilization of phycocyanin (PC)-containing NLs was performed through chitosan... |
41648010 | motA-mediated flagellar motility modulates biofilm formation and competitive nodulation in <i>Mesorhizobium ciceri</i> USDA 3378. | The introduced rhizobial inoculum <i>M. ciceri</i> USDA 3378 demonstrates a significant competitive advantage over the indigenous <i>M. muleiense</i> CCBAU 83963 for nodulating chickpea in newly established planting areas in China. Previous genomic analyses revealed that USDA 3378 possesses a greater number of genes re... |
41647741 | Designing a broad-spectrum multi-epitope vaccine against influenza A and <i>Mycoplasma pneumoniae</i>: an immunoinformatics approach. | <h4>Introduction</h4>Influenza A and <i>Mycoplasma pneumoniae</i> (<i>M. pneumoniae</i>) are common respiratory pathogens, causing severe co-infections in clinical diseases. Current vaccines have failed to provide comprehensive protection against both of the pathogens, highlighting the requirement of integrated solutio... |
41647688 | Snake envenomation in veterinary medicine: comparative insights and emerging therapies. | Snakebite envenomation poses a significant threat to both public health and animal welfare, resulting in substantial human suffering and economic burden worldwide. Recognized by the World Health Organization as a neglected tropical disease, snakebites disproportionately affect impoverished rural regions across Africa, ... |
41647646 | Characterization of two reductases <i>MaLAR</i> and <i>MaANR</i> revealed their roles in proanthocyanidin biosynthesis in mulberry. | Proanthocyanidins (PAs), polymers of flavan-3-ols, are crucial for the sensory quality and stress defense of mulberry (<i>Morus</i> spp.). The biosynthesis of their monomers, catechin and epicatechin, are catalyzed by leucoanthocyanidin reductase (<i>LAR</i>) and anthocyanidin reductase (<i>ANR</i>), respectively, repr... |
41647607 | Fluorescence molecular imaging technology: a promising new strategy for the diagnosis and treatment of gynecologic tumors. | Gynecologic malignancies such as ovarian, endometrial, and cervical cancers are characterized by challenges in early diagnosis and high therapeutic complexity, creating an urgent need for more precise imaging techniques. Fluorescence molecular imaging, a modality with high sensitivity and high spatial resolution, has d... |
41647359 | Regulatory framework for polymer-based nanotherapeutics in clinical translation. | Polymer-based nanotherapeutics (PNs) have emerged as versatile drug delivery platforms offering controlled release, targeted delivery, and improved pharmacokinetics across therapeutic areas. However, their structural complexity and nanoscale behavior pose significant regulatory challenges. Current frameworks still eval... |
41647278 | Inter-individual differences in weekly training load in international-level handball: the effect of congested match schedules. | <h4>Background</h4>Effective training load (TL) management is crucial for optimizing performance, especially in elite team sports, where congested schedules (≥ two matches a week) are common and can lead to fatigue accumulation. Understanding inter-individual variations in workload is a key to tailor training strategie... |
41646970 | Cross-tissue transcriptome-wide association identify novel T1D susceptibility genes and drug candidates. | <h4>Background</h4>The genetic mechanisms underlying type 1 diabetes (T1D) remain incompletely understood, limiting the development of targeted therapies.<h4>Methods</h4>We performed an integrative genetic analysis to identify T1D susceptibility genes and therapeutic targets. This included a cross-tissue transcriptome-... |
41646882 | Overview of polymeric polyplexes for dsRNA delivery in insects: complexation, stability, and design considerations. | Polymer-based delivery systems for double-stranded RNA (dsRNA) have gained attention as a promising strategy for RNA interference (RNAi)-mediated insect pest control. Despite encouraging <i>in vitro</i> results, their practical application remains limited by methodological inconsistencies and species-specific challenge... |
41646863 | The regulatory principles, physiological functions, and phase transition of biomolecular condensates. | Liquid-liquid phase separation (LLPS) is a crucial process that influences the spatial organization of cells. Dysregulation of this process can contribute to serious adverse outcomes, including neurodegenerative diseases, developmental disorders, and impaired immune responses. While various studies have explored how fa... |
41646842 | Nanoparticles in influenza research: a bibliometric analysis of global trends (2005 - 2025). | <h4>Background</h4>Influenza viruses cause approximately 3 to 5 million severe cases and tens of thousands of deaths globally each year, posing a continuous threat to public health. Nanoparticles with superior biocompatibility, combined with traditional Chinese herbal medicine could offer promising avenues to enhance t... |
41640574 | Exploring the anti-quorum sensing potential of synthetic lipstick dyes against <i>Pseudomonas</i> <i>aeruginosa</i>. | Lip care products such as balms, glosses, and lipsticks are widely used to enhance lip health, appearance, and protection. Lipsticks provide aesthetic appeal, social and psychological benefits, that act as a protective barrier against environmental stressors. However, growing concerns have emerged regarding chronic lip... |
41638079 | Calcium overloaded multifunctional composite nanomaterials synergistically treat cancer by ferroptosis pathway. | The treatment of pancreatic cancer has long been a global challenge. Strategies based on mitochondrial Ca<sup>2+</sup> overload-related ferroptosis have garnered significant attention. However, the various limitations of current Ca<sup>2+</sup> generators make it difficult to maintain an effective concentration of Ca<s... |
41638068 | Preparation of two new anionic β-cyclodextrin-based hybrid monolithic chiral stationary phases for CEC enantioseparations of drugs and molecular modeling of enantiomer-chiral selector interactions. | Two anionic β-cyclodextrin-based nanohybrid monolithic columns were synthesized and applied in CEC enantioseparation with UV detection. The first monolithic column was fabricated via a "one-pot" approach using glycidyl methacrylate-functionalized sulfated β-cyclodextrin (GMA-S-β-CD), sodium 3-mercaptopropanesulfonate, ... |
41624515 | Intravesical folate-conjugated hydroxyethyl starch micelles for pH-triggered co-delivery of epirubicin and TLR7 agonist toward synergistic chemoimmunotherapy of bladder cancer. | The immunosuppressive tumor microenvironment and poor drug targeting remain major obstacles in bladder cancer (BC) therapy. To address this, a combination strategy integrating chemotherapy and immunotherapy was employed by co-delivering epirubicin (EPI) and the immune modulator imiquimod (IMQ) using a folate-modified n... |
41610523 | Constructing atomically dispersed Fe-anchored Nanoislands on nitrogen-doped carbon catalysts for synergistic enhancing Fenton-like reaction dominated by singlet oxygen and high-valent metal‑oxygen species. | Single-atom catalysts (SACs) activating peroxymonosulfate (PMS) to metal-organic framework selective produce non-radical species has shown significant advantages in the field of pollutant degradation. However, in the PMS system, SACs face the dilemma of balancing activity and stability. This study proposes a Metal-Orga... |
41602148 | Functionalized two-dimensional nanochannel membranes to distinguish methylated/unmethylated peptides for sensing cellular G9a protein. | Histone methyltransferase G9a-catalyzed histone modifications serve as critical epigenetic marks that regulate diverse cellular functions. Aberrant enzymatic activities of G9a are closely associated with various human pathologies, making them promising biomarkers for disease diagnosis and therapeutic targeting. However... |
41600899 | Genetic Diversity of SARS-CoV-2 in Kazakhstan from 2020 to 2022. | Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has had major social and economic consequences worldwide. Whole genome sequencing (WGS) is essential for genomic monitoring, enabling tracking of viral evolution, detection of emerging variants, and identification of introductions and transmission chains to inf... |
41600761 | Multi-Omics Analysis Provides Insights into the Key Regulatory Pathways of Energy Metabolism in GIFT Under Salinity Stress. | Salinity stress represents a critical environmental constraint that significantly limits the development of tilapia aquaculture in brackish water environments. Its substantial impacts on fundamental physiological processes in fish, particularly osmotic balance, energy metabolism, and antioxidant defense mechanisms, hav... |
41600498 | Spiral-Grating Tapered Gold Tip Used for Micro-Nanoscale Multi-Functional Sensing. | Optical fiber surface plasmon resonance (SPR) sensing, as a label-free, highly sensitive, rapid-response and in situ detection technology, has demonstrated significant utility in various physical, chemical and biological detection applications. This paper focuses on a fiber-integrated microscale spiral-grating tapered ... |
41600133 | A Comprehensive Review on Steviol Glycosides: Sources, Properties, Bioactivities, Sensory-Functional Enhancement and Bioproduction Strategies. | Steviol glycosides (SGs) are high-intensity, zero-calorie natural sweeteners with demonstrated safety and potential health benefits, positioning them as ideal sucrose substitutes for metabolic disorder management. However, their broad application is limited by inherent drawbacks such as bitterness, low solubility, and ... |
41600122 | Essential Oil of <i>Prangos ferulacea</i> (L.) Lindl.: Chemistry and Bioactivities. | <i>Prangos ferulacea</i> (L.) Lindl. (Apiaceae) is an orophilous species with notable traditional uses, particularly across the broader Middle East region. Over the past 50 years, research on its essential oil has revealed the existence of several chemotypes. In addition to its chemical composition, there is also data ... |
41599949 | Overview of the Zinc Functional Interactome Through Health Hallmarks and Medical Conditions. | Zinc is an essential micronutrient involved in structural, catalytic, and regulatory functions across all levels of biological organization. Despite substantial advances over the past two decades, the zinc literature remains highly fragmented, with mechanistic, nutritional, and clinical findings often reported in isola... |
41599782 | Econazole Exhibits In Vitro and In Vivo Efficacy Against <i>Leishmania amazonensis</i>. | <b>Background/Objectives:</b> Cutaneous leishmaniasis (CL) remains a major neglected tropical disease, and current chemotherapeutic options are limited by toxicity and emerging resistance. Repurposing azole antifungals is a promising approach, as they target ergosterol biosynthesis, a pathway also essential in <i>Leish... |
41599431 | Effects of pH and Temperature on the Structure and Function of Pea Albumin. | Pea albumin is a high-quality plant-based protein with growing relevance in food applications, yet the effects of pH and thermal treatment on its structural and functional properties remain insufficiently understood. This study investigated the effects of environmental factors, namely pH (3, 5, 7, 9) and temperature (4... |
41599426 | Progress on Suzuki-Miyaura Cross-Coupling Reactions Promoted by Palladium-Lanthanide Coordination Polymers as Catalytic Systems. | Lanthanide coordination polymers have been developed at a fast rate during the past two decades due to their appealing applications in the modern field of materials science and emerging technologies like luminescence, magnetism, sensing, gas adsorption, and catalysis. The role of lanthanides in imparting specific prope... |
41597769 | Resolving the "Thick-Wall Challenge" in <i>Haematococcus pluvialis</i>: From Metabolic Reprogramming to Clinical Translation. | Astaxanthin, derived from <i>Haematococcus pluvialis</i>, is a potent antioxidant with significant therapeutic potential. However, its large-scale commercialization is hindered by the "thick-wall challenge", a phenomenon where the stress conditions required for astaxanthin accumulation also trigger the formation of res... |
41597768 | A Probiotic <i>Bacillus velezensis</i> Consortium Exhibits Superior Efficacy over Two Alternative Probiotics in Suppressing Swine Pathogens and Modulating Intestinal Barrier Function and Immune Responses In Vitro. | Despite increasing interest in probiotics as antibiotic alternatives in swine production, few studies have directly compared the functional efficacy of different commercial probiotic formulations under controlled conditions. We conducted an in vitro study using porcine intestinal epithelial (IPEC-J2) and macrophage-lik... |
41596712 | Gut Microbiota and Type 2 Diabetes: Genetic Associations, Biological Mechanisms, Drug Repurposing, and Diagnostic Modeling. | Gut microbiota is a potential therapeutic target for type 2 diabetes (T2D), but its role remains unclear. Investigating causal associations between them could further our understanding of their biological and clinical significance. A two-sample Mendelian randomization (MR) analysis was conducted to assess the causal re... |
41596715 | Molecular Identification and RNA-Based Management of Fungal Plant Pathogens: From PCR to CRISPR/Cas9. | Fungal diseases continue to limit global crop production and drive major economic losses. Conventional diagnostic and control approaches depend on time-consuming culture-based methods and broad-spectrum chemicals, which offer limited precision. Advances in molecular identification have changed this landscape. PCR, qPCR... |
41596718 | Metalloprotein-Based Nanomedicines: Design Strategies, Functional Mechanisms, and Biomedical Applications. | Metalloprotein-based nanomedicines integrate the multifunctionality of metal centers with the engineerability of proteins to construct advanced nanoplatforms for targeted delivery, diagnostic imaging, and multimodal therapy. In these nanomedicines, metal ions or clusters act as functional cores, enabling imaging contra... |
41596723 | Opportunities and Challenges of mRNA and VLP Technologies for Pan-Flavivirus Vaccine Development: Focus on Conserved Quaternary Epitope Conformations. | Mosquito-borne flaviviruses, including Dengue virus (DENV), Japanese encephalitis virus (JEV), West Nile virus (WNV), Yellow fever virus (YFV), and Zika virus (ZIKV), continue to present a significant threat to public health worldwide. In 2024, these viruses accounted for 11,717 reported cases in the United States and ... |
41596719 | Pathogen Evasion of Humoral Innate Immunity: Coping with C-Reactive Protein and Serum Amyloid A. | C-reactive protein (CRP) and serum amyloid A (SAA) are classical acute-phase proteins that exemplify humoral innate immunity, the soluble arm of the host's first-line defense. Beyond their traditional use as biomarkers of inflammation, both proteins function as active effectors against pathogens by binding microbial co... |
41596696 | In Silico Design and Characterization of a Rationally Engineered Cas12j2 Gene Editing System for the Treatment of HPV-Associated Cancers. | CRISPR-Cas9 systems have enabled unprecedented advances in genome engineering, particularly in developing treatments for human diseases, like cancer. Despite potential applications, limitations of Cas9 include its relatively large size and strict targeting requirements. Cas12j2, a variant ofCasΦ-2, shows promise for ov... |
41596194 | Shaping Lycopene Nanoparticles Performance: How Surfactants Influence Stability, Antioxidant Activity, and Uptake in Human Skin Spheroids. | There is a growing demand for plant-derived antioxidants to replace synthetic ones in skincare applications. Phytochemicals are characterized by certain limitations, including poor bioavailability and chemical instability, which affect their industrial exploitation. Tomato peel extract has been used as a source of lyco... |
41595781 | Extracellular Matrix in Human Disease and Therapy: From Pathogenic Remodeling to Biomaterial Platforms and Precision Diagnostics. | The extracellular matrix (ECM) is a dynamic, tissue-specific network that integrates biochemical and mechanical cues to regulate cell behavior and organ homeostasis. Increasing evidence indicates that dysregulated ECM remodeling is an upstream driver of chronic human diseases rather than a passive consequence of injury... |
41595762 | The Mechanism and Regulation of Disulfidptosis and Its Role in Disease. | Disulfidptosis is a recently identified form of regulatory cell death (RCD), Which has emerged as a research hotspot due to its distinctive feature of accumulating protein disulfide bonds, setting it apart from other RCD mechanisms. This discovery may offer new therapeutic strategies for cancer and various chronic dise... |
41594933 | Biotechnological Potential of Algerian Saffron Floral Residues: Recycling Phytochemicals with Antimicrobial Activity. | This study investigates the phytochemical profile, antioxidant capacity, and antimicrobial potential of <i>Crocus sativus</i> L. (saffron) tepal extracts obtained via different solvent systems. Here, a biochemical screening was performed using spectrophotometry and HPLC-DAD, while molecular docking simulations were car... |
41592858 | Substrate Specificity and Immunological Implications of <i>Cutibacterium acnes</i> Phage Endolysins. | <i>Cutibacterium acnes</i> resistance to antibiotics poses a significant challenge in treating acne vulgaris. Bacteriophages offer a promising alternative to overcome this challenge given their specificity. In the current study, 15 bacteriophages were isolated from acne affected volunteers and subjected to whole genome... |
41590318 | Smart Biosensing Nanomaterials for Alzheimer's Disease: Advances in Design and Drug Delivery Strategies to Overcome the Blood-Brain Barrier. | Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by persistent memory impairment and complex molecular and cellular pathological changes in the brain. Current treatments, including acetylcholinesterase inhibitors and memantine, only help with symptoms for a short time and do not stop the dise... |
41588907 | Nanobots in Assisted Reproduction: Enhancing Sperm Functionality for Male Infertility Treatment. | The potential of micro- and nanorobots in biomedical applications has drawn significant interest. These devices are modeled after natural organisms such as bacteria and sperm cells. By utilizing the propulsion mechanisms of motile sperm and other microorganisms, these biohybrid systems offer innovative approaches for d... |
41588899 | Novel Approaches in Targeted Drug Delivery for Treatment of Neuropathy. | Neuropathy, a devastating disorder of the peripheral nervous system, results in pain, numbness, and weakness, profoundly impacting quality of life. Conventional therapies provide insufficient alleviation, requiring targeted drug delivery systems (TDDS) to improve effectiveness and reduce adverse effects. This review ex... |
41588888 | Advances in Nose-to-Brain Delivery Systems for Effective Alzheimer's Disease Management. | Neurodegenerative diseases comprise a heterogeneous group of disorders characterized by the progressive structural and functional deterioration of neurons in the central nervous system. Among them, Alzheimer's disease is the most prevalent worldwide. Despite their distinct clinical manifestations, many neurodegenerativ... |
41584319 | Form follows function: morphology as a map of mechanisms in neurodegenerative disease pathology. | Across neurodegenerative diseases, the shape and spatial organization of pathology carry rich mechanistic information. Vacuoles, spongiosis, oligodendroglial coiled bodies, dendritic dystrophic neurites, amyloid plaque compactness, and phase-separated droplets each reflect distinct cellular identities, subcellular comp... |
41584827 | Advances in novel biomaterials for cardiovascular tissue engineering and regenerative medicine. | Cardiovascular diseases remain a leading cause of mortality worldwide, with conventional treatments such as pharmacotherapy and surgery presenting significant limitations. In recent years, novel biomaterials have emerged as a promising avenue in cardiovascular tissue engineering and regenerative medicine, offering inno... |
41579573 | Promoting photon-generated carrier separation via a type-II Cu<sub>2</sub>O@MOF heterojunction cathode for photo-rechargeable zinc-ion batteries. | Photo-rechargeable zinc-ion batteries (PR-ZIBs) represent an emerging renewable energy technology that offers a compact and efficient paradigm for direct solar energy conversion and storage. However, the development of high-performance photocathodes is hindered by challenges such as severe charge recombination and low ... |
41579537 | Smart evaluation of tea quality: machine learning-assisted SERS for white tea vintage authentication and grade classification. | Traditional sensory evaluation methods for tea-relying on empirical experience, visual colorimetry, and subjective taste perception-suffer from irreproducible inter-rater variability and inability to quantify bioactive markers, thus failing to establish scientifically verifiable quality standards. To address this, we d... |
41577116 | Microglial P2RY12 mediates migration to and protection of cerebral microvasculature after ischemia-reperfusion via Caveolin-1. | Disruption of blood-brain barrier (BBB) integrity after cerebral ischemia-reperfusion (I/R) injury contributes to neuroinflammation and neuronal damage. Microglia plays a significant role in the repair processes of the BBB, and the G protein-coupled receptor P2RY12 is involved in microglial chemotactic migration. Howev... |
41575850 | HP1γ self-assembles and cooperates with KAP1 in repression of long noncoding RNA AI662270 in ESCs. | HP1s are involved in the assembly of heterochromatin and transcriptional regulation. Here, we report the molecular mechanisms underlying binding of the chromoshadow domain of HP1γ (HP1γ<sub>CSD</sub>) to the transcriptional co-repressor KAP1 and HP1γ self-assembly. Using crystallography, NMR, and mass photometry, we sh... |
41574205 | High-sensitivity ethanol vapor detection using In<sub>2</sub>O<sub>3</sub>@ZnO core-shell nanomeshes fabricated <i>via</i> block copolymer templating. | Metal-oxide semiconductor nanowires are promising building blocks for high-performance gas sensors due to their high specific surface area and tunable electronic properties. In this work, we adapted a single-step synthesis based on block copolymer templates to fabricate indium oxide (In<sub>2</sub>O<sub>3</sub>) nanowi... |
41573144 | Dissolution of cellulose derivatives in NaOH/urea aqueous solvent and optimisation of a cationic cellulose/carboxymethyl cellulose hydrogel using response surface methodology. | This study presents the synthesis and optimisation of a cellulose-based hydrogel derived from oil palm empty fruit bunch (OPEFB) waste <i>via</i> a sustainable green chemistry approach. Cationic cellulose (CC) was prepared through a cationisation using diallyl dimethyl ammonium chloride (DADMAC), followed by dissolutio... |
41573141 | Influence of dextrose monohydrate on the optical properties and adsorption activity of Ni<sub>0.6</sub>Zn<sub>0.2</sub>Sb<sub>0.2</sub>Fe<sub>2</sub>O<sub>4</sub> nanoferrites: towards multifunctional applications. | Dyes are noxious substances that are frequently found in industrial effluent. Metal ferrites are magnetic nano-adsorbents and may be affordable and effective in removing pollutants. Capping these nanoparticles increases their stability and prevents them from aggregating. In this investigation, Ni<sub>0.6</sub>Zn<sub>0.... |
41573129 | Bimetallic Copper-Manganese Zeolitic Imidazolate Framework Nanozyme Scavenges Reactive Oxygen Species to Alleviate Osteoarthritis via Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Axis and Autophagic Flux Restoration. | Osteoarthritis (OA) is the fastest-growing cause of physical disability worldwide, yet no therapy currently halts its age-dependent progression. Increasing evidence suggests that reactive oxygen species (ROS) are central drivers of cartilage degradation and OA progression. Therefore, the clearance of ROS is critical fo... |
41566961 | Resonant Enhancement of Photolysis through Plasmon-Vibrational Coupling. | The coupling of photonic modes and molecular vibrations is an emerging method for modifying the chemical reactivity of target molecules. However, since the photonic mode typically arises from a Fabry-Pérot cavity, it presents challenges for the systematic investigation of chemical reaction rates that require external s... |
41566854 | Solution Structures and Dynamics of Diamagnetic Lu- and Y-DOTAM/Fluoride Ternary Complexes: The Role of <sup>19</sup>F-CEST in the Detection of the Complex Fluoride Speciation. | This study deals with the synthesis and <sup>1</sup>H, <sup>13</sup>C, and <sup>19</sup>F-NMR characterization of ternary complexes formed upon the addition of fluoride ions to Lu- and Y-DOTAM. The application of the <sup>19</sup>F-CEST protocols allowed to get more insight into the complex speciation of the products o... |
41566851 | Autonomous Hydrogel Actuators Programmed by Endogenous Biochemical Logic for Dual-Stage Morphing and Drug Release. | Designing soft materials that autonomously respond to complex physiological environments remains a fundamental challenge in biomedical systems engineering. Here, we report on a 3D-printed hybrid protein-polymer hydrogel actuator that operates via endogenous biochemical logic, enabling fully autonomous dual-stage shape ... |
41566824 | A Single-Phase Mixed Ion-Electron Conducting Metal-Organic Framework. | Mixed ionic-electronic conductors (MIECs) are highly sought after for electrochemical systems because they support concurrent charge and mass transport. Yet, structurally well-defined single-phase MIECs remain scarce, as most systems rely on physical mixtures of ionic and electronic conductors. Here, we introduce a cat... |
41566795 | Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models. | Nanotechnology holds substantial promise across medicine, industry, and environmental science, yet its rapid advancement raises important concerns about potential impacts on both human health and ecosystems. This review explores evidence on alternative bridging models that connect cellular responses to organism-level o... |
41566757 | Dynamic Decoration of DNA Scaffolds for High-Resolution Cancer Cell Subtyping. | Precise imaging of cancer cells serves as the foundation for subtype analysis, significantly advancing the development of precision medicine. The unavoidable cellular internalization of fluorescent labels constrains the resolution and timeliness, presenting a significant obstacle. This study introduces a dynamic decora... |
41566747 | Machine Learning-Enhanced Analysis of Exosomal Surface Sialic Acid Using Surface-Enhanced Raman Spectroscopy for Ovarian Cancer Diagnosis and Therapeutic Monitoring. | Currently, the absence of ovarian cancer (OC)-specific biomarkers impedes the development of precise noninvasive diagnostic and monitoring strategies. Exosomal surface sialic acid (SA), a key mediator of intercellular communication and disease progression, emerges as a promising biomarker, though its role in OC remains... |
41566667 | Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome. | A balanced SUMOylation equilibrium safeguards the functional anti-tumor immune response. Oncogene activation drives SUMOylation, rendering aberrant SUMOylation a hallmark of cancer. To delineate the impact of activated SUMOylation on the tumor-immune synapse, we applied HLA class-I-targeted ligandomics and identified a... |
41566610 | Microenvironment-Guided Evolution of ssDNA-SWCNT Probes for Selective Recognition of Aggressive Prostate Cancer Phenotypes. | Despite advances in prostate cancer detection, distinguishing indolent from aggressive phenotypes remains challenging. We report a microenvironment-guided strategy for evolving phenotype-specific molecular probes using single-stranded DNA-functionalized single-walled carbon nanotubes (ssDNA-SWCNTs). Our approach employ... |
41566389 | Lactylation in cancer: molecular mechanisms and advances in clinical study. | Lysine lactylation (Kla), first described in 2019, is an emerging post-translational modification that converts lactate availability into changes in chromatin state and protein function. In cancer, where glycolysis and microenvironmental hypoxia often elevate lactate, lactylation has been linked to transcriptional repr... |
41566366 | Dual-responsive zwitterionic hydrogel microneedle patch for the on-site detection of two alzheimer's disease - related miRNAs. | Nowadays, specific biomarkers and detection methods for the early, rapid and non-invasive diagnosis of Alzheimer's disease (AD) are scarce. MiR-34a and miR-206 are both upregulated in the cerebrospinal fluid and peripheral fluids of AD patients. In view of the similar biochemical information between interstitial fluid ... |
41566353 | Continuous and noninvasive respiratory effort monitoring: a narrative review of emerging techniques. | Ventilator-induced lung injury and diaphragm dysfunction are well-recognized complications of mechanical ventilation and commonly attributed to inadequate ventilator settings. Excessive or insufficient assistance and the patient's own respiratory effort are increasingly acknowledged as important factors in the pathogen... |
41566213 | Optomechanical Probes with Tailored Material and Shape Asymmetry Assembled Using DNA Origami. | Optically trapped microscopic probes with precisely defined size, shape, and composition can be used for quantitative environmental sensing and for parametric investigation of fundamental physical phenomena at the classical-quantum boundary. The preparation of uniform ensembles of such probes is challenging, particular... |
41565909 | Characterization of Eudragit Nanoparticle-Tailored β-Cyclodextrin/Thiolated Sodium Alginate/Polyethyleneglycol Polymer Hybrid as a Potential Bone Tissue Engineering Scaffold. | The current study aims to develop a polymer hybrid scaffold functionalized with Eudragit nanoparticles, having an inherent effect on bone tissue regeneration. Thiolated sodium alginate (TSA) was combined with β-cyclodextrin (β-CD) and polyethylene glycol (PEG) as the interlinking polymer to design the hydrogel scaffold... |
41565815 | Fibroblastic reticular cells direct the initiation of T cell responses via CD44. | The movement of dendritic cells and T cells within secondary lymphoid organs is critical for the development of adaptive immune responses<sup>1,2</sup>. Central to this process is the fibroblastic reticular cell (FRC) network, which forms a highly organized conduit system that facilitates the movement of and interactio... |
41565709 | A gradient-structured all-cellulose biofoam enabled by solvent-induced molecular assembly for sustainable insulation modules. | Plastic foams play a crucial role across various industries and building constructions, due to their lightweight structure, thermal insulation properties, and energy absorption capabilities. However, the escalating global demand for petrochemical-based foams is raising significant environmental concerns. Here, we repor... |
41565700 | In situ self-assembled cell reservoir hydrogel for maneuvering multistage radioimmunotherapy. | Radiotherapy (RT) is a clinical mainstay of cancer treatment that triggers tumor-specific immune responses. However, the effectiveness is usually hampered due to the hypoxic tumor microenvironment (TME) and the ambivalent impact of RT on the immune landscape of tumors. Herein, we develop an injectable hydrogel encapsul... |
41565665 | Iterative discovery of potent polymeric antibiotics via multi-stage and multi-task learning against antimicrobial resistance. | Drug-resistant bacterial infections pose a serious threat to global health, driving the development of antibacterial strategies beyond classic antibiotics. Host defense peptide mimetic polymeric antibiotics have emerged as promising candidates to combat drug resistance, however, navigating the vast chemical space of po... |
41565654 | Phospholipid composition strongly affects the assembly of β barrel proteins into purified bacterial outer membranes. | Virtually all integral outer membrane proteins (OMPs) produced by Gram-negative bacteria contain a unique 'β barrel' structure that serves as a membrane spanning domain. The universal barrel assembly machine (BAM) catalyzes OMP assembly (folding and membrane insertion) in vivo, and purified Escherichia coli BAM that is... |
41565645 | WDR5 remodels NANOG condensates to drive transcriptional programs and sustain stem cell identity. | Stem cell pluripotency relies on a finely tuned interplay between transcription factors and epigenetic regulators. Here, we identify a direct interaction between NANOG, a master pluripotency transcription factor, and WDR5, a core chromatin regulator essential for maintaining stem cell identity. Mechanistically, WDR5 re... |
41565639 | From TDP-43/RNA complex formation to disease-linked TDP-43 aggregation through a structural and cellular approach. | Many RNA-binding proteins (RBP) have been associated to several neurodegenerative diseases for which RBP-rich cytoplasmic inclusions represent a major histological hallmark. However, among RBPs, the occurrence with which TDP-43, a nuclear mRNA-binding protein, is detected in cytoplasmic inclusions is exceptionally high... |
41565634 | Flexible light-emitting diodes with EQE approaching 26.4% from horizontal dipole-oriented metal nanoclusters. | Metal nanoclusters, as unique metallic molecules comprising a few to hundreds of metal atoms and stabilized by organic monolayer ligands, have recently emerged as a novel class of chromophores and hold great promise for flexible light-emitting diodes. However, the fabrication of flexible metal nanoclusters-based light-... |
41565615 | SNORA49 negatively regulates self-renewal of liver cancer stem cells and hepatocarcinogenesis via suppressing SOX9 transcription. | Cancer stem cells (CSCs) play a critical role in tumor initiation, progression, and recurrence. How liver CSCs initiate their self-renewal remains elusive. Here we identify a conserved small nucleolar RNA (snoRNA), SNORA49, which is lowly expressed in liver CSCs, as a negative regulator of CSC self-renewal. SNORA49 kno... |
41565596 | Biomimetic Approach to the Formation of Protein Materials via Complex Coacervation of Engineered Polypeptides. | Protein liquid-liquid phase separation underlies the formation of membraneless organelles in cells and plays a key role in the assembly process of natural materials such as the assembly of tropoelastin into elastic fibers. Here, we engineered a series of charged elastin-like polypeptides (ELPs) that form complex coacer... |
41565251 | CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-2. | The third <i>Critical Assessment of Computational Hit-finding Experiments</i> (CACHE) challenged computational teams to identify chemically novel ligands targeting the macrodomain 1 of SARS-CoV-2 Nsp3, a promising coronavirus drug target. Twenty-three groups deployed diverse design strategies to collectively select 173... |
41564426 | Discovery of Crystallized and Weakly Coupled Aggregates of Pseudocyanine Iodide. | We present a new class of pseudocyanine iodide (PIC-I) aggregates formed by freeze-induced self-assembly into layered ribbon structures. Unlike conventional PIC J-aggregates with head-to-tail dipole alignment, these ribbons adopt a complex and mixed HJ-aggregate arrangement. Unexpectedly, the aggregate ribbons exhibit ... |
41564420 | Visualization of EGFR Assembly and Activation Induced by a Protein Nanocage Using Cryo-Electron Tomography. | The epidermal growth factor receptor (EGFR) mediates signal transduction by triggering downstream phosphorylation to regulate cell proliferation. However, the complexity of the cellular environment has limited in situ structural investigations of membrane proteins within their native context. Here, we present a proof-o... |
41564383 | Mechanistic insights into psoriasis and type 2 diabetes mellitus comorbidity - Implications for treatment: A review. | Psoriasis is a chronic systemic inflammatory disease primarily affecting the skin, yet it is increasingly recognized for its systemic implications, particularly its strong association with type 2 diabetes mellitus (T2DM). This review synthesizes recent mechanistic and clinical evidence to elucidate the shared pathways ... |
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