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41564359 | Everyday Clothing Reimagined as Rapid-Acting Hemostatic and Antimicrobial Dressings for Emergency Trauma Care. | Uncontrolled hemorrhage and wound infection are leading causes of preventable death in prehospital trauma care. Everyday garments, often used as improvised bandages, provide only passive compression without intrinsic bioactivity. Here, we report a low-cost cotton fabric engineered to split into bandages with rapid hemo... |
41564358 | An Organoborate Monoxide Radical. | The boron monoxide radical has emerged as a fascinating molecule and a short-lived intermediate, previously observed only under matrix isolation conditions. In this study, we report the successful synthesis and characterization of a stable organic boron monoxide radical, achieved through the reaction of a diboron (6) d... |
41564278 | Ion-Size Controlled Non-Classical Crystallization of Metal-Oxide Nanoparticles Covered with a Few Highly Charged Ligands. | Densely ligated metal and metal-oxide nanoparticles (NPs) tend to assemble into superlattices (SLs) of different symmetries determined by a delicate balance of dominant interparticle forces. However, the organic protecting ligands typically used to stabilize NPs often block substrate access to their reactive surfaces, ... |
41564190 | Expanding DNA alphabet adds a previously unknown dimension to nanostructures. | DNA nanotechnology has created nanostructures with astonishing complexity. However, with nanostructures becoming increasingly larger and more intricate, they have become more difficult to obtain in high yields and quality. Expanding the alphabet beyond the canonical base pairs can therefore be the key to push the techn... |
41564183 | Two-dimensional lamellar nanosheet membranes with intrinsic size-sieving nanopores for ultrafast hydrogen separation. | Hydrogen separation and purification are essential for the large-scale application of green hydrogen energy. Two-dimensional (2D) material-based membrane technology provides an energy-efficient approach; however, the existing 2D lamellar membranes and nanoporous membranes struggle with low permeability and complex prep... |
41564169 | Phosphatidylcholine-Polycaprolactone Linear-Dendritic Copolymers for Selective Intracellular Drug Delivery and Improved Antitumor Efficacy. | Phosphatidylcholine and its derivatives are highly attractive for their ability to enhance both the circulation stability and the cellular uptake of drug carriers. However, the mechanism underlying the phospholipid surface function and the impact of phospholipid density on micelle performance remain poorly understood. ... |
41564123 | Structural characterization of the HDV virion and its ribonucleoprotein. | Hepatitis D virus (HDV) is a small RNA satellite virus of hepatitis B virus (HBV) which encodes a single protein, HDV delta antigen (HDAg), that is required for replication. Viral replication occurs independently from HBV and relies primarily on host RNA polymerase(s). Bulevirtide, a viral entry inhibitor, is the only ... |
41564102 | Fecal microbiota transplantation ameliorates radiation-induced lung injury by reshaping gut metabolic homeostasis to activate FAM134B-mediated ER-phagy. | Radiation-induced lung injury (RILI) is a serious complication of thoracic radiotherapy, with limited effective treatment options. This study demonstrates that fecal microbiota transplantation (FMT) confers protection against RILI through modulation of the gut-lung axis. In a total lung irradiation (TLI) mouse model, F... |
41563994 | Identification of hypoxia- and mitophagy-related diagnostic biomarkers for ulcerative colitis based on bioinformatic analysis and machine learning. | <h4>Background</h4>Ulcerative colitis (UC) is a chronic nonspecific inflammatory bowel disease of unknown etiology that is associated with a significant risk of progression to colorectal cancer. The aim of this study was to systematically identify hypoxia- and mitophagy-related molecular signatures associated with UC, ... |
41563931 | Elastically Bendable Metal-Organic Framework Crystals for Efficient Flexocatalytic Hydrogen Evolution from Water. | As a new type of porous material, metal-organic frameworks (MOFs) have emerged as promising platforms for mechanocatalytic hydrogen evolution from water splitting via piezocatalysis. However, because MOFs usually possess symmetric structures, only a few can be utilized as piezocatalysts, which generally exhibit a low c... |
41563687 | Entropy-Driven Cellulosic Elastomer Self-Assembly for Mechanical Energy Harvesting and Self-Powered Sensing. | The rapid advancement of flexible electronics technology has placed higher demands on the structural design and performance regulation of elastic materials. Cellulosic elastomers, with their biodegradability, renewability, and tunability, emerge as ideal candidate materials. Entropy-driven self-assembly promotes the sp... |
41563481 | GhTPS11, underlying an early-maturity QTL cluster on Chr. D08, positively regulates flowering through the age pathway in cotton. | <h4>Key message</h4>We identified GhTPS11 as a positive regulator of flowering in cotton through integrating QTL mapping, transcriptomic analysis and functional assays. Early maturity is one of the most essential targets in cotton breeding improvement. Enhancing early maturity can facilitate cotton rotation, thereby in... |
41563468 | Na<sup>+</sup> Uptake Triggered in Adrenal Chromaffin Cells by a 5-ns Electric Pulse is Facilitated by Ca<sup>2+</sup> Influx Via an L-Type-Like Ca<sup>2+</sup> Channel Independent of Changes in Membrane Potential. | Whole-cell voltage patch clamp studies have shown that in bovine adrenal chromaffin cells held at -70 mV, a single 5-ns, 5 MV/m pulse activates a membrane conductance carried partially by Na<sup>+</sup> through TRPC4/5 channels and the sodium leak channel (NALCN). Here we used fluorescence imaging with the Na<sup>+</su... |
41563391 | Floor Temperature-regulated Poly(ether-alt-ester) With Thermal Stability and Chemical Recyclability Enabled by Polycondensation-Depolymerization-Repolymerization Strategy. | Creating innovative poly(ether-alt-ester)s (PEAEs) with alternating ether and ester groups to address the trade-offs between the polymer's depolymerizability and thermostability is essentially important for advanced material applications and sustainable development. Current research efforts focus on modulating the ceil... |
41563327 | Bayesian Optimization for High-Dimensional Coarse-Grained Model Parameterization: A Case Study on Pebax Polymer. | Coarse-grained (CG) force field models are extensively utilized in material simulations because of their scalability. Ordinarily, these models are parametrized using hybrid strategies that sequentially integrate top-down and bottom-up approaches. However, this combination restricts the capacity to jointly optimize all ... |
41563118 | Leveraging Electrochemical Diversity in Engineering Liquid-State Ionic Devices for Neuromorphic Computing. | Implementing the brain's electrochemical principles in liquid-state ionic devices for neuromorphic computing has gained notable momentum. A unique advantage of such devices is the abundance of ions and molecular species available for electrochemical signaling. In this work, we demonstrate that electrochemical diversity... |
41563149 | Dual-Responsive Diatomite Microcarriers for Biocompatible Targeted Delivery of Emamectin Benzoate Against Plutella Xylostella. | Agricultural sustainability is significantly threatened by pesticide residues. Carrier-mediated delivery technology promising as versatile tool enhances pesticide delivery efficiency, reduces pesticide residues and biological toxicity. However, conventional carriers often penetrate crop tissues and are not directly ing... |
41563121 | Single-molecule validation and optimised protocols for the use of secondary nanobodies in multiplexed immunoassays. | Recently developed secondary nanobodies or single-domain antibodies present a powerful tool for immunodetection. Unlike traditional antibodies, their monovalence enables pre-association with primary antibodies prior to sample staining, presenting a straightforward affinity-based antibody labelling solution. This not on... |
41562884 | Suckerin Colloids and Hydrogels With Low Immunogenicity as Resorbable and Hemostatic Tissue Adhesives for Wound Healing. | Squid sucker ring teeth proteins (suckerins) have recently been shown to exhibit higher molecular-level adhesion than mussel adhesive proteins-a well-known class of wet-resistant adhesive proteins-and can also assemble into nanoparticles in aqueous conditions. Herein, we present recombinant suckerin-12 colloids and hyd... |
41562869 | π-π Stacking-Assisted Self-Assembly Fabricates Highly Uniform PANI@RGO Cathodes Toward High-Performance Aqueous Zinc-Ion Batteries. | Polyaniline (PANI) is a promising cathode for aqueous zinc-ion batteries (AZIBs) due to its fast redox kinetics and eco-friendliness. However, the main challenges are still far from expectations owing to their morphological aggregation and low specific surface area. Herein, we report an N-methyl-2-pyrrolidone (NMP)-ena... |
41562626 | Triptolide in renal disorders: dual roles of therapeutic potential and nephrotoxicity: a narrative review. | <h4>Background</h4>Triptolide (TP), derived from <i>Tripterygium wilfordii</i>, exhibits anti-inflammatory, immunosuppressive, and antifibrotic properties with potential for treating renal diseases, but its clinical use is restricted by dose-dependent nephrotoxicity.<h4>Objective</h4>The aim of this review is to compre... |
41562620 | AP2: an indispensable host factor in virus infection. | Adaptor protein complex 2 (AP2), a central regulator of clathrin-mediated endocytosis and intracellular cargo trafficking, is hijacked by numerous viruses to complete their infectious cycles. This review systematically synthesizes the multifaceted roles of AP2 across the entire viral life cycle, from entry and replicat... |
41562622 | Impaired neutralizing antibody responses against the BA1.1, BA.2, and BA.5 Omicron SARS-CoV-2 subvariants in hospitalized adults infected with pre-Omicron variants in Argentina. | Infection with SARS-CoV-2 variants typically confers protective humoral immunity. Yet, the Omicron variant demonstrates a considerable capacity to evade immune responses in individuals previously infected with other SARS-CoV-2 strains. This has prompted investigation into Omicron's potential resistance to neutralizing ... |
41562539 | Making and Breaking: Supramolecular Chirality Modulation via Stepwise Assembly and Disassembly of Nano-Size Trizinc(II)Porphyrin Trimers. | A molecular-level understanding of supramolecular chirality amplification and attenuation is established through the coordination-driven self-assembly of a 'nano-size' achiral Zn(II)porphyrin trimer (host) and a series of chiral diamino esters (substrates). The processes occur through the stepwise formation of polymer ... |
41562402 | Rational Design Strategies for Stimuli-Responsive DNAzymes Using Modified and Artificial Nucleotides. | DNA, traditionally regarded as genetic material, has emerged as a versatile building block in molecular technology. Catalytic DNA oligomers known as DNAzymes, especially those capable of cleaving target RNA at specific sites, have shown great potential in DNA-based diagnostics, therapeutics, and dynamic DNA nanotechnol... |
41562349 | Biosensor-Based Platforms for the Detection and Screening of <i>Mycobacterium leprae</i> Infection. | Leprosy remains an important neglected tropical disease with about 200,000 new cases detected annually worldwide. Although the disease is highly responsive to treatment, a timely and accurate diagnosis continues to be a critical barrier to disease control. Traditional diagnostic methods, including PCR, bacilloscopy, hi... |
41562305 | Engineering Thermoresponsive Dielectric Properties and Phase Transitions via Confinement of Polar Cations in Photoisomerizable Nitroprusside Frameworks. | Crystalline materials capable of responding to both heat and light stimuli offer unique opportunities for tunable dielectric behavior but have remained scarcely explored. Using a hydrogen-bond-guided supramolecular strategy, we synthesized a family of nitroprusside-based hybrids, (A)(NH<sub>4</sub>)[Fe(CN)<sub>5</sub>(... |
41562302 | An LSPR-Based Kinetic Framework for Polyelectrolyte Molecular Weight Determination: A Proof-of-Concept Study. | Determining the molecular weight of polyelectrolytes remains a persistent challenge because conventional techniques such as size-exclusion chromatography (SEC) often require added salt, calibration against neutral polymers, and complex optimization to overcome chain-column interactions. Here we introduce a kinetics-bas... |
41562276 | Study of Calcitriol Interaction with the Vitamin D Receptor Using DFT and TD-DFT Calculations. | Calcitriol, the primary active metabolite of vitamin D, has garnered significant research interest due to its role in several pathologies. However, excessive calcitriol levels or heightened sensitivity of the vitamin D receptor (VDR) can lead to hypercalcemia, motivating the search for analogues that preserve therapeut... |
41562251 | A Modular DNAzyme for Precise Visualization and Intervention of Alternative Splicing Isoforms in Live Cells. | Alternative splicing is a fundamental mechanism that enhances proteomic diversity and modulates gene function, with its dysregulation being a hallmark of numerous diseases. Despite its biological significance, the real-time monitoring of spliced mRNA isoforms in living cells remains challenging due to limited specifici... |
41562239 | Water-Soluble Metal Phthalocyanines Enable Molecularly Dispersed Heterogeneous Electrochemical CO<sub>2</sub> Conversion. | Molecular electrocatalysts offer the prospect of atomically defined active sites and tunable reactivity, yet their integration into heterogeneous systems is frequently hindered by limited site accessibility and reduced catalytic performance. Overcoming molecular aggregation and improving electronic coupling with conduc... |
41560683 | Internal-Friction Network Piezoelectric Hydrogel Microspheres Achieve Physiological Electrical Adaptation to Regulate Mitochondrial Autophagy in Degenerative Tissues. | Mitochondrial autophagy imbalance critically drives apoptosis and tissue degeneration, requiring physiological electrical adaptation to meet cellular thresholds. However, degenerative tissues exhibit deficient endogenous electrical signals, disrupting cellular energy transfer. Using supramolecular engineering and micro... |
41560672 | Structure-Activity Relationships of Anabaenopeptins as Carboxypeptidase and Phosphatase Inhibitors. | Anabaenopeptins are a family of cyanobacterial cyclic peptides that display potent enzyme inhibition, particularly against carboxypeptidases A and B, as well as the serine/threonine phosphatases PP1 and PP2A. Defined by a 19-membered macrocyclic ring and a ureido-linked exocyclic amino acid, these compounds vary consid... |
41560627 | Ultrasound Controlled-Release Hydrogel Promotes Diabetic Wound Healing via Neuroimmune Modulation and Synergistic ROS Scavenging. | Diabetic wound (DW) is a diabetes complication characterized by high morbidity and disability rates. Previous therapeutic systems focused on macrophages while neglecting the upstream regulatory factor of neuropeptide-mediated neuroimmune communication. In addition, precise delivery is directly important for the treatme... |
41560619 | Antibodies to watch in 2026. | The Antibodies to Watch article series provides annual updates on commercial late-stage clinical development, regulatory review, and marketing approvals of antibody therapeutics. Since the first article was published in 2010, the late-stage pipeline has grown from 26 antibody therapeutics to over 200, while during the ... |
41559683 | Injectable multi-component hydrogels for the treatment of ascites caused by hepatocellular carcinoma via anti-tumor and reduction of ascites generation. | Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related death worldwide, and malignant ascites (MA) caused by HCC is almost incurable. However, the efficacy of chemotherapy is limited by poor tumor drug targeting and the presence of an immunosuppressive microenvironment. Therefore, it is urgen... |
41511555 | Unraveling the impact of cyclic peptide primary structure on rotaxane formation through umbrella sampling molecular dynamics simulations. | Peptide-based rotaxanes have attracted interest due to their expected unique physical and functional properties, which are not observed in conventional peptide-based materials. Cyclic peptides, when their primary structure is appropriately designed, are characterized by their ability to form stable host-guest complexes... |
41504867 | Correction: Asymmetric synthesis of isoindolines <i>via</i> a palladium-catalyzed enantioselective intramolecular oxidative aminoacetoxylation reaction. | Correction for 'Asymmetric synthesis of isoindolines <i>via</i> a palladium-catalyzed enantioselective intramolecular oxidative aminoacetoxylation reaction' by Dongyuan Ju <i>et al.</i>, <i>Org. Biomol. Chem.</i>, 2025, https://doi.org/10.1039/d5ob01595b. |
41489407 | Cooperative many-body interactions and spectroscopic signatures in (HCN)<sub><i>n</i></sub> and (HNC)<sub><i>n</i></sub> clusters up to <i>n</i> = 15. | We present a comprehensive computational investigation of hydrogen cyanide (HCN) and its higher-energy isomer, hydrogen isocyanide (HNC) clusters, from dimers to 15-mers. Clusters were generated using the PyAR automated build-up algorithm, which incrementally assembles n-mers from monomers <i>via</i> random orientation... |
41481145 | Concluding remarks: <i>Faraday Discussion</i> on Frontiers in physical chemistry in lignin valorization. | The valorisation of lignin, the only high-volume, naturally occurring aromatic biopolymer, represents an essential frontier for the sustainable production of chemicals and materials. However, despite its tremendous potential, lignin still remains the "dark horse" of biorefining - harbouring great promise yet still insu... |
41439393 | New core-expanded calix[4]pyrroles and N-donor-extended dipyrromethanes: syntheses, anion binding and conformational studies. | A series of dipyrromethane-based N-donor-extended dipodal receptors (2a-c) and <i>meso</i>-(1,3)-modified expanded calix[4]pyrroles (3a-c) were synthesized <i>via</i> Mannich reactions. While the two non-equivalent <i>meso</i>-substituents at the dipyrromethane unit(s) in both the acyclic and macrocyclic Mannich bases ... |
41437871 | Impact of phenothiazine-to-phenoxazine replacement in hexaphyrin frameworks on structural, spectroscopic, and redox properties. | Three phenoxazine-embedded hexaphyrins were synthesized from commercially available phenoxazine in a few simple steps and compared with our previously reported phenothiazine-embedded hexaphyrins. A striking structural distinction was observed between these two series. The phenoxazine-embedded hexaphyrins showed a more ... |
41428361 | Anion recognition in water by a simple bis-squaramide with charge-enhanced acidity. | Synthetic anion receptors that function in water are typically elaborately designed macrocycles and cages, as a high level of pre-organisation is required to overcome the free energy cost from anion desolvation. The low yields and the use of dilute conditions associated with the synthesis of macrocycle/cage-based anion... |
41403340 | Encapsulated enzyme with metal-organic frameworks (enzyme@MOFs): unlocking potential in pharmaceutical and industrial applications. | Currently, enzyme-MOF (enzyme@MOF) systems, where enzymes are immobilized within MOF structures, have become important in pharmaceutical and industrial research due to their enhanced stability, reusability, and catalytic performance. This review explores the pharmaceutical and industrial applications of enzyme@MOFs, hi... |
41370822 | Evaluating and improving biocompatibility of conductive polymers for cardiac tissue engineering. | Conductive polymers (CPs) have gained increasing attention in cardiac tissue engineering (CTE) due to their ability to restore electrical conductivity, enhance cardiomyocyte (CM) function, and support tissue regeneration. Despite significant progress in the field, challenges related to variability in biocompatibility t... |
41044961 | Molecular weight dependent water uptake and dynamics in lignin-based epoxy anticorrosive coatings. | While the challenges of incorporating raw softwood kraft lignin (KL) as particulate pigments in epoxy coatings were addressed using mechanically sieved, size-fractionated lignin, and its corrosion resistance was evaluated, a key question remains: does solvent fractionation, which yields lower molecular weight lignin, o... |
40977561 | Spiers Memorial Lecture: organic, physical & polymer aspects pivotal in lignin valorization. | This article addresses current challenges in lignin chemistry by exploring four thematic areas. We begin by examining the major chemical transformations that occur in lignin and discuss the emerging structural understanding of technical lignins. The discussion then shifts to lignin fractionation strategies, which are e... |
40970360 | Supramolecular interactions in softwood kraft lignin nanoparticles. | The production of functional (nano)materials based on lignin as a renewable starting material depends on the thorough understanding of lignin's physico-chemical properties, among which self-assembly and agglomeration/aggregation are the most important. Nevertheless, the knowledge about the structure-property relations ... |
42006041 | RNA-Micelles as Self-Assembling Structures for Efficient Co-Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis. | SiRNA has been widely studied in cancer gene silencing over the last 25 years. However, few siRNA-based therapeutics have been approved by the FDA. An RNA-micelle platform provides a powerful therapeutic tool through simple one-step, high-yield production that is capable of efficient colorectal cancer lung metastasis t... |
41869400 | Gold Nanoparticles in Bladder Cancer Applications: A Paradigm Shift from Diagnostic Tools to Integrated Theranostic Platforms. | <h4>Background</h4>Bladder cancer, particularly non-muscle-invasive bladder cancer (NMIBC), poses significant clinical challenges due to its high recurrence rate. Traditional diagnostic approaches such as cystoscopy and urine cytology have limitations, including invasiveness and insufficient sensitivity. Gold nanoparti... |
41810468 | <i>In vivo</i> self-assembled siRNAs targeting VEGFR2 and mTOR for renal cell carcinoma treatment. | Renal cell carcinoma (RCC) is a challenging urologic malignancy characterized by its aggressive nature, including invasion, metastasis, and treatment resistance. To explore multi-targeted therapies, we established an advanced clear cell renal cell carcinoma (ccRCC) model via orthotopic tumor transplantation in mice, an... |
41810462 | Carrier-free reduction-responsive self-assembling paclitaxel dimer nanoprodrug synergizing with celastrol for enhanced chemoimmunotherapy. | Chemotherapeutic paclitaxel (PTX) formulations are widely used in clinical cancer treatment; however, they are also associated with concomitant programmed death-ligand (PD-L1) upregulation and an immunosuppressive microenvironment. Herein, we rationally designed carrier-free, reduction-sensitive PTX dimer self-assembli... |
41767128 | The Effectiveness of Digital Therapeutics Intervention in Oral Anticoagulation Management: A Systematic Review and Meta-analysis. | <h4>Objective</h4>To summarize the key intervention characteristics and evaluate the effectiveness and safety of digital therapeutics (DTx) in patients receiving oral anticoagulation, with effectiveness evaluated using time in therapeutic range (TTR), thromboembolic events, and mortality, and safety evaluated based on ... |
41755863 | Diterpene Molecular Glue Stabilizes Protein-Protein Interactions of a Disordered Phosphoprotein that Controls Translational Repression. | Chemical stabilization of protein-protein interactions involving intrinsically disordered phosphoproteins is an emerging yet challenging problem. Synthetic agents capable of achieving this goal are desirable for advancing understanding of the biological roles of these transient interactions and for developing new thera... |
41755833 | Small Molecule Activator of Phosphatase PP2A Remodels Scaffold PR65 Structural Dynamics To Promote Holoenzyme Assembly. | Small molecule activators of protein phosphatase 2A (PP2A), hereafter SMAPs, have attracted substantial interest for their potential to inhibit cancer cell proliferation by targeting PR65, the scaffold subunit of the PP2A heterotrimer. PR65 is a uniquely flexible and stable molecule composed of 15 tandem HEAT (Huntingt... |
41696602 | Recent advances in lead halide perovskite single crystals for optoelectronic devices. | Over the past decade, perovskite materials have driven significant innovations in optoelectronics due to their exceptional photoelectric performance, drawing substantial global research attention. Specifically, the certified power conversion efficiency (PCE) of single-junction perovskite solar cells has reached 27.37%,... |
41684845 | Mollusk shells as marine bioactive materials: Composition, bioactivities, and prospects for food and health applications. | Marine mollusk processing generates large quantities of shells that serve as abundant but underutilized biofunctional materials. Composed mainly of calcium carbonate with a minor organic matrix of proteins, polysaccharides, and chitin, mollusk shells exhibit characteristic activities such as antioxidant, anti-inflammat... |
41675653 | Computational Prediction of the Complete Adsorption-Regeneration Cycle of Functionalized Metal-Organic Frameworks for Atmospheric Water Harvesting. | This work presents a comprehensive multiscale computational investigation of the complete adsorption-regeneration cycle of functionalized adsorbents for atmospheric water harvesting (AWH) under low-humidity conditions. The target system is copper-docked MOF-303, a nanoporous framework with well-defined nanoscale channe... |
41658192 | Hit-Identification to Novel Antileishmanial Agents from a β‑Pinene Scaffold: from Synthesis to <i>In Vitro</i> Evaluation and <i>In Silico</i> SAR/ADMET Profiling. | β-Pinene, a low-cost natural product derived from agricultural waste, has shown <i>in vitro</i> activity against <i>Leishmania amazonensis</i>, but its use is hindered by unfavorable pharmacokinetic properties. Herein, we report a straightforward two-step synthesis of β-pinene-derived hydroxysulfides followed by an <i>... |
41658180 | Dissecting Tin-Based Activation and Anomerization Pathways in Carbohydrate Chemistry. | Tin-based Lewis acids are widely used in glycosylation chemistry, but their precise mechanistic role is still not fully understood. In this study, we combine <sup>119</sup>Sn NMR spectroscopy and density functional theory (DFT) calculations to investigate how Sn-(IV) promoters interact with glycosyl donors and influenc... |
41658089 | A Rare Octahedral Yb(III) Complex Exhibiting Field-Induced Single-Molecule Magnet Behavior. | Ytterbium-(III) complexes have attracted growing interest due to their unique magnetic properties and potential applications in molecular magnetism. From this perspective, the synthesis, structural characterization, and magnetic and theoretical studies of a new mononuclear Yb-(III) complex, [YbI<sub>2</sub>(OPPh<sub>3<... |
41641337 | Type VIII collagen: advances in matrix biology and translational promise. | Type VIII collagen, a member of the short-chain collagen family, plays essential roles in structural support, functional regulation, and mechanobiology across multiple organ systems. Although early studies suggested ubiquitous expression, emerging single-cell transcriptomic and proteomic analyses have refined this view... |
41641265 | A secreted C-type lectin in Periplaneta americana functioning in antibacterial activity, innate immune signaling and leg regeneration. | <h4>Introduction</h4>C-type lectins are important pattern-recognition receptors that play essential roles in innate immune responses by recognizing pathogen-associated molecular patterns. However, their biological functions in <i>Periplaneta americana</i> have not been systematically investigated.<h4>Methods</h4>Two Pa... |
41641269 | Cancer immunotherapy insights: key takeaways from the ADSCC bone marrow and cellular therapy congress 2024. | The rising global cancer burden underscores the urgent need for innovative and effective therapies. Molecular and cellular immunology advances have revolutionized cancer immunotherapy, transforming laboratory discoveries into clinical breakthroughs. The Second Bone Marrow Transplant and Cellular Therapy Congress, held ... |
41641000 | Mechanisms to medicines: navigating drug repurposing strategies in Alzheimer's disease. | Alzheimer's disease (AD) represents a continuously advancing neurodegenerative condition distinguished by the unremitting deterioration of cognitive abilities and memory impairment, which significantly hampers daily functioning of life. In the absence of disease modifying treatments, it continues to pose a significant ... |
41640758 | Genome-wide identification and expression profiling of <i>DnaJ</i> gene family in <i>Gossypium barbadense</i> reveals candidate thermotolerance genes. | <h4>Introduction</h4>Heat stress is one of the primary abiotic stress factors affecting plant growth, seriously compromising crop quality and yield. The <i>DnaJ</i> gene family functions as a crucial component of molecular chaperones, playing a vital role in protein folding, unfolding, translocation, and degradation.<h... |
41640677 | Mechanistic insights into Shenqi Dihuang decoction in the treatment of immunoglobulin a nephropathy. | <h4>Background</h4>Immunoglobulin A nephropathy (IgAN) is among the most prevalent glomerular disorders. Shenqi Dihuang decoction (SQD) has demonstrated therapeutic efficacy in various renal conditions, but its effects on IgAN remain insufficiently explored. The present investigation was designed to explore the potenti... |
41635429 | Plasmonic Properties of Icosahedral-Seeded Gold Nanostars. | Gold nanostars (AuNSs) exhibit rich plasmonic responses that are highly sensitive to the number, orientation, and relative length of their legs. Here, we use the boundary element method to investigate the optical properties of experimentally realistic AuNSs grown from icosahedral seeds. The simulated extinction spectra... |
41604959 | Recent advances in metal-organic framework-based nanozymes for cancer theranostics driven by synthetic innovation and machine learning design. | Nanozymes are engineered nanomaterials designed at the atomic scale to fine-tune their structure, composition, and electronic properties, thereby creating active sites that mimic those of natural enzymes. Among these materials, Metal-organic frameworks (MOFs) are notable for their well-defined, porous frameworks, which... |
41630882 | Soy protein isolate-pectin from <i>Nicandra Physaloides</i> (Linn.) Gaertn seeds nanogels: A hydrocolloid system for blueberry preservation. | Resveratrol (Res) and Phloretin (Pht) are natural compounds with antioxidant and anti-inflammatory activities, yet their practical applications face certain limitations. In this study, nanogels were utilized as carriers to enhance their characteristics and bioactivities. Soy protein isolate (SPI) and pectin (NPGP) deri... |
41630810 | The carbon quantum dots: Preparation, antibacterial mechanisms, and application in food packaging. | In recent years, food spoilage and deterioration caused by microbial contamination have become increasingly serious. Traditional food packaging materials can inhibit the growth and reproduction of microorganisms, thereby extending the shelf life of food. Unfortunately, traditional packaging materials have limitations, ... |
41630781 | Omics-based dissection of alternative splicing and the regulatory architecture in fungal genomes. | Assigning mechanistic and functional associations to most of the widespread splicing diversity in fungi has been one of the continuous and most intriguing challenges in the field of molecular mycology. Ongoing advances in sequencing technologies have driven recent outbreaks in the study of the dynamic splicing landscap... |
41625500 | Integrated fabrication of a shape-adaptable, antioxidative composite stent for effective closure and biological repair of enteroatmospheric fistula. | Enteroatmospheric fistulas (EAFs) pose significant clinical challenges due to persistent leakage, inflammation, and impaired epithelial repair. Transcriptomic analyses of fistula tissues reveal elevated oxidative stress, mitochondrial dysfunction, and barrier disruption. Current provisional closure devices lack adaptab... |
41624511 | Inflammation-targeted single-atom nanozymes drive microglial depolarization and inhibit ferroptosis via Sirt-6-xCT-GPX4 axis to attenuate early brain injury following subarachnoid hemorrhage. | Early brain injury (EBI) has been identified as a key factor leading to the poor prognosis of patients with subarachnoid hemorrhage (SAH). At present, apart from surgical treatment, there is a lack of effective neuroprotective drugs. In this study, a biomimetic nanozyme V-MDL-800 was constructed by coordinating Vanadiu... |
41621332 | Effects of drinking water temperature in summer on growth performance, water consumption, surface temperature, blood parameters, and intestinal development of geese from 14 to 42 days of age. | This study aimed to investigate the effects of drinking water temperature on growth performance, water consumption, surface temperature, blood parameters, and intestinal development in geese, and to determine the optimal drinking water temperature for geese aged 14 to 42 days during summer. A total of 192 14-day-old ma... |
41607705 | Isolation of Antigen-Specific Nanobodies From Synthetic Libraries Using a Protein Selection Strategy That Combines MACS-Based Screening of YSD and FLI-TRAP. | Although protein-protein interactions (PPIs) are central to nearly all biological processes, identifying and engineering high-affinity intracellular binders remains a significant challenge due to the complexity of the cellular environment and the folding constraints of proteins. Here, we present a two-stage complementa... |
41602781 | Structure-dependent thermochromism of PAZO thin films: theory and experiment. | Poly[1-[4-(3-carboxy-4-hydroxyphenylazo)benzenesulfonamido]-1,2-ethanediyl, sodium salt] (PAZO) exhibits a range of unique physical properties that are critical for its diverse applications in photonics, optoelectronics, memory devices, and sensing technologies. In this study, we investigate the thermochromic behavior ... |
41600489 | Gold Nanoparticle-Enhanced Dual-Channel Fiber-Optic Plasmonic Resonance Sensor. | Surface plasmon resonance (SPR) sensors based on photonic crystal fibers (PCFs) hold significant promise for high-precision detection in biochemical and chemical sensing. However, achieving high sensitivity in low-refractive-index (RI) aqueous environments remains a formidable challenge due to weak light-matter interac... |
41600484 | NTFold: Structure-Sensing Nucleotide Attention Learning for RNA Secondary Structure Prediction. | Determining RNA secondary structures is a fundamental challenge in computational biology and molecular sensing. Experimental techniques such as X-ray crystallography, nuclear magnetic resonance, and cryo-electron microscopy can reveal RNA structures with atomic precision, but their high cost and time consuming nature l... |
41600118 | Exogenous Methyl Jasmonate Mediates Secondary Metabolic Reprogramming to Enhance Resistance in Tea Plants. | Tea plants are frequently threatened by insect pests, resulting in substantial yield and quality losses. Methyl jasmonate (MeJA) is a key defense signaling molecule in plants; however, its integrated effects on tea plant growth, resistance, and quality-related traits remain poorly understood. In this study, field exper... |
41599779 | Integrated <i>In Vitro</i> and <i>In Silico</i> Profiling of Piperazinyl Thiosemicarbazone Derivatives Against <i>Trypanosoma cruzi</i>: Stage-Specific Activity and Enzyme Inhibition. | <b>Background:</b><i>Trypanosoma cruzi</i>, the causative agent of Chagas disease, remains a major public health concern, and there is a continued need for new antitrypanosomal agents. Thiosemicarbazone (TSC) derivatives have emerged as a promising class of compounds with potential antiparasitic activity. <b>Objectives... |
41599576 | Pitch-Based Activated Carbon Fibers: Activation Influences and Supercapacitor Applications. | Pitch-based activated carbon fibers, recognized for their excellent electrical conductivity, mechanical strength and durability, offer a compelling electrode alternative in the development of next-generation supercapacitors. In this review, we provide insight into the critical role of porosity in enhancing pitch-based ... |
41599574 | Polyacid Solutions as an Analogue of a Neural Network. | Despite the increased interest in neuromorphic materials-a physical implementation of neural networks that could overcome the so-called von Neumann architecture's limitations-most studies have been performed on the basis of systems specially constructed for this purpose. It has previously been shown that analogues of n... |
41599571 | Self-Healing Polymer Nanocomposites: Mechanisms, Structure-Property Relationships, and Emerging Applications. | Self-healing polymer nanocomposites are increasingly investigated as damage-tolerant materials for structural and functional applications; however, their engineering translation remains limited by the difficulty of achieving high mechanical reinforcement while retaining sufficient polymer mobility for effective repair.... |
41599420 | Interaction of Lysozyme with Sulfated β-Cyclodextrin: Dissecting Salt and Hydration Contributions. | This article investigates the thermodynamic driving force of the interaction between lysozyme (Lys) and sulfated β-cyclodextrin (β-CDS), with a particular emphasis on the elusive role of hydration during polyelectrolyte-protein binding. Using isothermal titration calorimetry (ITC), the binding affinity was quantified a... |
41599414 | Computational Identification of Blood-Brain Barrier-Permeant Microbiome Metabolites with Binding Affinity to Neurotransmitter Receptors in Neurodevelopmental Disorders. | The gut microbiome produces thousands of metabolites with potential to modulate central nervous system function through peripheral or direct neural mechanisms. Tourette syndrome, attention-deficit/hyperactivity disorder, and autism spectrum disorder exhibit shared neurotransmitter dysregulation and microbiome alteratio... |
41599413 | Nutritional and Antioxidant Profile of Brown <i>Eragrostis tef</i> (Zucc.) Trotter Flour in Blends with <i>Glycine max</i> (L.) Merr. Flour. | The still-growing demand for nutritious gluten-free products necessitates the development of a composite flour that addresses the nutritional deficiencies common in conventional gluten-free formulations. This study aimed to comprehensively characterize brown teff (<i>Eragrostis tef</i> (Zucc.) Trotter) and soybean (<i>... |
41599412 | Construction and Advanced Utilization of Self-Assembled and Scale-Down Chitin Nanofibers for Polymer Composite Design. | This review provides a comprehensive overview of recent progress in chitin-based nanomaterials and their composite engineering. Particular focus is placed on techniques for constructing self-assembled chitin nanofibers (ChNFs) with tightly bundled fibrillar structures, as well as strategies for fabricating composites i... |
41599237 | Albumin Nanoparticles as Multifunctional Carriers for Advanced Therapeutics. | Modern medicine requires effective, continuous, and safe therapies, which largely depend on the targeted delivery and activity of the drug. This goal can be achieved by designing drug delivery systems with improved pharmacokinetic properties and enhanced drug transport to the affected tissue. Human serum albumin (HSA) ... |
41599236 | Phthalimide Derivatives as Anti-Inflammatory Agents: In Silico COX-2 Targeting and In Vitro Inhibition of PGE<sub>2</sub> Production. | <b>Background/Objectives</b>: The development of specific inhibitors for cyclooxygenase-2 (COX-2) is a challenge for public health. A series of 17 <i>N</i>-phthalimide hybrids was evaluated using a functional M06 meta-GGA hybrid in combination with a polarized 6-311G (d, p) basis set. The top three candidates (<b>6</b>... |
41599235 | Pharmaceutical Cocrystals in Drug-Delivery Technologies: Advances from Rational Design to Therapeutic Applications. | Pharmaceutical cocrystals are a well-established class of solid-state forms that can modulate the solubility, dissolution, stability, and bioavailability of active pharmaceutical ingredients without altering their molecular identity. Although traditional oral formulations have demonstrated translational potential, rece... |
41596966 | Valorization of Dairy and Plant By-Products as Functional Ingredients in Kurt (Dried Fermented Milk Product): Effects on Nutritional, Physicochemical, and Sensory Properties. | This study developed enriched kurt formulations using buttermilk protein sediment, spray-dried whey, soy protein concentrate, and flaxseed cake, and assessed their effects on composition, physicochemical parameters, microbiological stability, and sensory quality. Protein content increased from 46.2% in the control to 4... |
41596972 | A Two-Step Strategy for Aroma Restoration of Strawberry Concentrate Based on ZIF-67@PDMS Composite Membrane. | An organophilic composite membrane, ZIF-67@PDMS, was fabricated to enhance the isolation of natural aromatic compounds. The as-prepared composite membrane was characterized using SEM, EDS, FTIR, XRD, and contact angle measurement. In comparison to pure PDMS, ZIF-67@PDMS, featuring a loading capacity of 2.5 wt% of PDMS ... |
41596686 | Lipidomics in Melanoma: Insights into Disease Progression and Therapeutical Targets. | Melanoma is the deadliest form of skin cancer, characterized by high metastatic potential and intrinsic heterogeneity. In addition to genetic mutations such as BRAF^V600E^ and NRAS, lipid metabolic reprogramming has emerged as a critical factor in tumor progression and therapy resistance. Lipid metabolism supports mela... |
41596677 | The Renin Angiotensin System: Insights into the Role of ACE2 in Glomerular Injury Including SARS-CoV-2 Infection. | The circulating renin-angiotensin-aldosterone system (RAAS) plays a key role in regulating blood volume and electrolyte levels. While important for the maintenance of intravascular volume systemically, the local activation of tissue RAAS and the generation of angiotensin II contribute to inflammation and fibrosis. In t... |
41596665 | Redefining the Collagen Composition of Human Fasciae: Emerging Collagen Types and Structural Heterogeneity. | Fascia has traditionally been described as a passive connective tissue mainly composed of collagen types I and III. Recent research, however, has revealed its structural and functional complexity, suggesting the possible presence of additional collagen types. This study aimed to quantify the presence and distribution o... |
41596666 | Single-Nucleus Transcriptional Profiling Revealed Cell Diversity and Albino Mutation Mechanism in the Skin of <i>Channa argus</i>. | Body color is the most prominent phenotypic trait in animals. To investigate the molecular regulatory mechanisms underlying skin pigmentation and body color in <i>Channa argus</i>, single-nucleus RNA sequencing technology was employed to analyze cell diversity and functional changes in the skin of normal and albino <i>... |
41596660 | Research Progress on the Regulatory Effect of Curcumin on Mesenchymal Stem Cells. | Curcumin is the main active ingredient in Curcuma longa turmeric, with a wide range of biological effects. It shows significant therapeutic potential in the field of stem cell therapy. This article aims to explore the modulatory effects and underlying mechanisms of curcumin on mesenchymal stem cells (MSCs), providing a... |
41595756 | Restoration of Interaction Between Fatty Acid Oxidation and Electron Transport Chain Proteins In Vitro by Addition of Recombinant VLCAD. | <b>Background/Objectives:</b> We have previously demonstrated that fatty acid oxidation (FAO) enzymes physically and functionally interact with electron transfer chain supercomplexes (ETC-SC) at two contact points. The FAO trifunctional protein (TFP) and electron transfer flavoprotein dehydrogenase (ETFDH) interact wit... |
41595527 | Engineered Mesenchymal Stromal Cells in Oncology: Navigating Between Therapeutic Delivery and Tumor Promotion. | Mesenchymal stromal cells (MSCs) are intensively investigated in oncology owing to their intrinsic tumor-homing ability and capacity to deliver therapeutic agents directly into the tumor microenvironment (TME). Recent advances in genetic engineering have enabled precise modification of MSCs, allowing controlled express... |
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