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41658166 | Casein/Albumin Silver/Zinc Oxide Nanoparticles for Efficient Dispersive Solid-Phase Microextraction of Phenolic Compounds from Aqueous Solutions Followed by UV-Visible Spectrometry. | The increasing presence of phenolic compounds in water sources from industrial and agricultural operations demands the development of effective, environmentally sustainable extraction and detection techniques. Casein/albumin-silver/zinc oxide nanoparticles (CAS/ALB-Ag/Zn NPs) have been produced and effectively characte... |
41658153 | Fabrication and Adsorptive Performance of Carbon Nanotube/Polypyrrole@poly(acrylonitrile-<i>co</i>-styrene) Nanofibers for Sustainable Removal of Methyl Orange Dye from Aqueous Media. | This work reports the fabrication and application of electrospun carbon nanotube/polypyrrole@poly-(acrylonitrile-<i>co</i>-styrene) (CNT/Ppy@PAN-ST) nanofibers as efficient adsorbents for the removal of methyl orange (MO), a carcinogenic azo dye, from water. SEM analysis confirmed uniform nanofibers with diameters of 1... |
41658140 | Charge-Transfer Complexes and Fluorescence Modulation in Amide- and Carboxy-Substituted 2‑Phenyl-1,3,2-benzodiazaboroles. | A library of amide- and carboxy- functionalized 2-phenyl-1,3,2-benzodiazaborole derivatives was synthesized via microwave-assisted cyclic condensation to explore the effects of pseudoaromaticity on charge-transfer complex (CTC) formation and photophysical behavior. All compounds were characterized by NMR, IR, UV-vis, a... |
41658107 | Antidepressant-Like Activity of Naringenin, an Important Agro-Industrial Resource, Complexed with β‑Cyclodextrin. | The objective of this work was to investigate the effect on the central nervous system (CNS) of naringenin (NR) and of the inclusion complex obtained with its incorporation into β-cyclodextrin (NR-βCD) in mice, using experimental models. The possible participation of the monoaminergic system in the antidepressant activ... |
41635857 | Ginkgo biloba extract suppresses hepatocellular carcinoma progression by inhibiting the recruitment of myeloid-derived suppressor cells through reduced CXCL1 secretion via SRC downregulation. | <h4>Background</h4>Hepatocellular carcinoma (HCC) remains one of the leading causes of cancer-related mortality worldwide, characterized by poor prognosis and limited therapeutic efficacy. Ginkgo biloba extract (GBE) has demonstrated antitumor potential, yet its precise molecular mechanisms in HCC are not fully underst... |
41635851 | Macrophage-derived chemokines in T cell regulation: implications for cancer immunotherapy. | Macrophages are pivotal regulators of immunity, with intercellular communication being a central mechanism of their function. Among these communications, chemokines act as critical messengers in macrophage-T cell crosstalk. This review systematically elucidates the notable roles of macrophage-derived chemokines in modu... |
41625497 | Synergistic targeting of senolytic and senomorphic action with dual-engineered biomimetic macrophage nanovesicles for mitigating osteoarthritis. | Osteoarthritis (OA), a leading cause of chronic disability worldwide, is increasingly recognized to be driven by the accumulation of senescent chondrocytes (sCDs) and their deleterious pro-inflammatory senescence-associated secretory phenotype (SASP). Existing therapies, including senolytics and senomorphics, lack cell... |
41624530 | Copper-enriched zinc peroxides induced cuproptosis through concurrent metabolic and oxidative dysregulation for boosting immunotherapy in colorectal cancer. | Despite the immunotherapy has achieved the progress for advanced colorectal cancer, the unsatisfactory treatment effect remains a challenge due to the deficient immune response. In this work, we constructed a tumor microenvironments (TME)-responsive biodegradable cuproptosis inducer (ZnO<sub>2</sub>-Cu@HA, ZCH) through... |
41624531 | Fiber-integrated hydrogels: a versatile platform to improve structural and biological performance in 3D biofabrication. | Hydrogels emerged as versatile biomaterials for tissue engineering due to their extra cellular matrix similarity and mechanical and biochemical properties. Still, hydrogels expose limited stiffness, anisotropy and nutrient diffusion. By reinforcing hydrogels with synthetic and natural fibers, these drawbacks can be eff... |
41624518 | Colloid-patterned surfaces distinguish malignant mechanophenotypes. | Accurate and rapid identification of aggressive cancer cells remains a major clinical challenge. Here, we present a simple, label-free mechanophenotyping platform that integrates controlled colloidal topographies with particle-uptake measurements to reveal biophysical traits associated with metastatic progression. Non-... |
41619583 | Charting the evolving landscape of kinase hinge-binding chemotypes beyond flatland: a systematic analysis and opportunities for sp<sup>3</sup>-rich binders. | ATP-competitive kinase inhibitors represent one of the most successful modalities in targeted therapy, yet their discovery has historically relied on a narrow repertoire of hinge-binding motifs. Here, we report a large-scale structural analysis of 4370 kinase-ligand complexes spanning 289 human protein kinases, providi... |
41613799 | Detection of Prostate Carcinoma in an Asymptomatic Individual Initiated by an Immunological Biopsy-A Case Report. | <h4>Background</h4>With a total of 1.46 million new cases and 396,792 deaths in 2022, prostate cancer is a major medical challenge around the world. Detecting and treating cancer at earlier, preferably localized stages can significantly increase survival rates. Here, a novel blood-based cancer screening as a pre-test i... |
41613807 | Evolution or Revolution in Colorectal Cancer Treatment: Present and Future of New Therapeutic Options. A Narrative Review. | Colorectal cancer (CRC) is the third most common malignancy worldwide and the second leading cause of cancer-related deaths, accounting for approximately 10% of all cancer cases. By 2050, CRC incidence is expected to rise substantially, driven by population aging and greater exposure to risk factors in developing count... |
41613789 | A Holistic Review of Oncological Drug Targets and Trajectories of Resistance in Cancer Therapy. | The prolonged and intricate history of oncological treatments has transitioned significantly since the introduction of chemotherapy. Substantial therapeutic benefits in cancer therapy have been achieved by the integration of conventional treatments with molecular biosciences and omics technologies. Human epidermal grow... |
41602134 | Subporphyrazine scaffolds as emerging electron acceptors for long-lived charge separation. | Using subporphyrazines (SubPzs) as electron acceptors in the modular design, <i>via</i> metal-ligand axial coordination with ruthenium(ii) phthalocyanine (Ru(CO)Pc), was key to dictating the different photophysical evolution in four electron donor-acceptor Ru(CO)Pc-SubPz conjugates (1-4). Complementary absorptions of S... |
41601009 | A Pool of Ferritin Nanoparticles Delivering Six Proteins of African Swine Fever Virus Induces Robust Humoral and Cellular Immune Responses in Pigs. | <b>Background/Objectives</b>: Inadequate characterization of protective antigens poses a significant challenge to the development of vaccines for African swine fever (ASF), particularly for antigen-dependent formulations such as subunit, mRNA, and recombinant viral vector vaccines. To address this, we aimed to screen A... |
41599929 | Dietary (-)-Epigallocatechin Gallate (EGCG): State-of-the-Art Advances in Bioactivities, Bioavailability Enhancement Strategies, and Applications in Nutrition and Health. | (-)-Epigallocatechin gallate (EGCG), a major polyphenolic compound in tea leaves, exhibits potent antioxidant, anti-inflammatory, and anticancer properties. Despite its therapeutic potential, poor bioavailability limits clinical efficacy. This review comprehensively examines the sources, and multifunctional bioactiviti... |
41599925 | The Multidirectional Biological Activity of Resveratrol: Molecular Mechanisms, Systemic Effects and Therapeutic Potential-A Review. | <b>Background/Objectives:</b> Resveratrol is a multi-target polyphenolic stilbene widely studied for its antioxidant, anti-inflammatory, cardioprotective, hepatoprotective, neuroprotective, immunomodulatory and anticancer properties. This review summarizes current evidence on its molecular mechanisms, therapeutic poten... |
41599561 | New Features on Mechanical Behavior of Polymeric Materials. | This Special Issue, devoted to new features on "Mechanical Behavior of Polymeric Materials", includes many exciting works related to this frontrunner polymer Research and Development area [...]. |
41599402 | Manganese-Iron-Supported Biomass-Derived Carbon Catalyst for Efficient Hydrazine Oxidation. | This study presents a straightforward strategy for producing novel, effective and inexpensive functional non-noble metal-supported carbon materials made from abundant natural biomass. These materials offer a cost-effective alternative to noble metals for the oxidation of hydrazine (HzOR) and demonstrate the potential f... |
41599398 | A Review of Gas-Sensitive Materials for Lithium-Ion Battery Thermal Runaway Monitoring. | Lithium-ion batteries (LIBs) face the safety hazard of thermal runaway (TR). Gas-sensing-based monitoring is one of the viable warning approaches for batteries during operation, and TR warning using semiconductor gas sensors has garnered widespread attention. This review presents a comprehensive analysis of the latest ... |
41599389 | Advances in Targeting BCR-ABL<sup>T315I</sup> Mutation with Imatinib Derivatives and Hybrid Anti-Leukemic Molecules. | Resistance to imatinib remains a therapeutic challenge, largely driven by point mutations within the kinase domain of the <i>BCR-ABL</i>, among which the <i>T315I</i> substitution constitutes the most clinically significant barrier. Ponatinib effectively inhibits this mutant form but is limited by dose-dependent cardio... |
41599387 | Data Hidden in Sewage: Advanced Methods for Identification and Quantification of Synthetic Cannabinoids in Urban Wastewater. | Synthetic cannabinoids (SCs) represent one of the rapidly growing groups of new psychoactive substances (NPS) on the illicit drug market. SCs mimic the effects of Δ<sup>9</sup>-tetrahydrocannabinol, but they have a greater affinity to the receptors, resulting in more potent psychoactive effects than traditional substan... |
41599378 | Halogen as Template to Modulate the Structures of the Nanocage-Based Silver(I)-Thiolate Coordination Polymers. | By the reaction of AgNO<sub>3</sub>, 2-methyl-2-propanethiol (HS<i>t</i>Bu), with various-sized halogen ions as templates, three multi-nuclear silver-thiolate cluster-based chain-like coordination polymers, [Ag<sub>6</sub>(<i>μ</i>-SBu)<sub>6</sub>]<sub>n</sub> (<b>USC-CP-2</b>), [Ag<sub>6</sub>(<i>μ</i>-S<i>t</i>Bu)<s... |
41599095 | Natural Protective Mechanisms of <i>Cucumis callosus</i> Leaves in <i>Escherichia Species</i>-Induced Urinary Tract Infection: An Integrated In Silico and In Vivo Study. | Leaves of <i>Cucumis callosus</i>, traditionally employed in Ayurvedic medicine for the treatment of urinary disorders, were investigated in depth for their therapeutic potential against bacterially induced urinary tract infection (UTI) for the first time. The present work is the first to explore the antibacterial acti... |
41599087 | Antiviral Role of Surface Layer Protein A (SlpA) of <i>Lactobacillus acidophilus</i>. | Norovirus is associated with vomiting and diarrhea and, in severe cases, can result in death. Currently, there is no effective treatment or vaccine for this virus. Bilateral interactions have been reported between gut microbiota and viral infection. Our laboratory has been studying the Surface layer protein A (SlpA) of... |
41598113 | Circular Dichroism via Extrinsic Chirality in Achiral Plasmonic Nanohole Arrays. | The detection of chiral properties is crucial for pharmacology and biochemistry, yet standard circular dichroism spectroscopy suffers from low sensitivity when probing minute sample volumes. While complex asymmetric chiral nanostructures can enhance these Circular Dichroic (CD) signals, their fabrication is intricate a... |
41596639 | Uncovering Major Structural and Functional Features of Methyl-Coenzyme M Reductase (MCR) from <i>Methanobrevibacter ruminantium</i> in Complex with Two Substrates. | Structural insights into methyl-coenzyme M reductase from <i>Methanobrevibacter ruminantium</i> (<i>M. ruminantium</i>) has implications for methane mitigation strategies. Methanogenesis in ruminants is a major contributor to global greenhouse gas emissions, primarily driven by the rumen archaeon <i>M. ruminantium</i>.... |
41596621 | Graphene-Based Nanosystem for Targeted Delivery of Anti-Sense miRNA-21 on Hepatocellular Carcinoma Cells. | The application of nanotechnology in medicine has garnered significant interest, particularly in the development of advanced drug delivery systems. Graphene oxide (GO) shows promise as a carrier for delivering microRNA (miRNA) mimics or antisense constructs. miRNAs play a crucial role in regulating gene expression, and... |
41596183 | Transcriptome and Gene Family Analyses Reveal the Physiological and Immune Regulatory Mechanisms of <i>Channa maculata</i> Larvae in Response to Nanoplastic-Induced Oxidative Stress. | The increasing accumulation of plastic debris in aquatic environments has raised concerns about the ecotoxicological effects of polystyrene nanoplastics (PSNPs). This study examined PSNPs toxicity during a critical developmental stage by exposing 15 days post-fertilization (dpf) larvae of blotched snakehead (<i>Channa ... |
41595746 | Recent Update Targeting Autophagy-Apoptosis Crosstalk Using Bioactive Natural Products for Ovarian Cancer Treatment. | Ovarian cancer remains a top mortality contributor within gynecological cancers because patients receive diagnoses late in the disease course and conventional treatment resistance along with high recurrence rates cause poor outcomes. Aberrant regulation of autophagy and apoptosis has a critical role in the development,... |
41594702 | In Silico Ligand-Based Screening of PDB Database for Searching Unique Motifs Against SARS-CoV-2. | SARS-CoV-2, the virus responsible for coronavirus disease COVID-19, is a highly transmissible pathogen that has caused substantial global morbidity and mortality. The ongoing COVID-19 pandemic caused by this virus has had a significant impact on public health and the global economy. One approach to combating COVID-19 i... |
41594138 | Lipopeptide Engineering: From Natural Origins to Rational Design Against Antimicrobial Resistance. | Lipopeptides (LPs) have evolved from naturally occurring compounds to key therapeutic agents against multidrug-resistant (MDR) bacterial infections. However, their expanding clinical use has triggered emerging resistance mechanisms, posing serious challenges to anti-infective therapy. This systematic review outlines th... |
41592434 | Zn evaporation-coupled heterostructure and doping in MOF-derived V<sub>2</sub>O<sub>3</sub>@C nanorods: Boosting high-rate aqueous Zn-ion batteries. | Aqueous zinc-ion batteries (ZIBs) are bottlenecked by vanadium-based cathodes with inferior conductivity, sluggish Zn<sup>2+</sup> transport, and structural instability. Herein, we design Zn-doped V<sub>2</sub>O<sub>3</sub>@C (Zn-V<sub>2</sub>O<sub>3</sub>@C) nanorods via MOF-derived annealing, integrating Zn evaporati... |
41591049 | BINOL-Based Zirconium Metal-Organic Cages: Self-Assembly, Guest Complexation, Aggregation-Induced Emission, and Circularly Polarized Luminescence. | The development of nanoscale chiral materials with enhanced optical properties holds significant promise for advancing technologies in light-emitting devices and enantioselective sensing. Here, we report the self-assembly of chiral metal-organic cages from an axially chiral, AIE-active binaphthyl dicarboxylate ligand. ... |
41590114 | pH-Sensitive Dextrin-Based Nanosponges Crosslinked with Pyromellitic Dianhydride and Citric Acid: Swelling, Rheological Behavior, Mucoadhesion, and In Vitro Drug Release. | Dextrin-based nanosponges (D-NS) are promising candidates for oral drug delivery due to their biocompatibility, mucoadhesive properties, and tunable swelling behavior. In this study, pH-sensitive nanosponges were synthesized using β-cyclodextrin (β-CD), GluciDex<sup>®</sup>2 (GLU2), and KLEPTOSE<sup>®</sup> Linecaps (L... |
41573115 | Infrared nanoscopy for subcellular chemical imaging. | Infrared (IR) nanoscopy represents a collection of imaging and spectroscopy techniques capable of resolving IR absorption on the nanometer scale. Chemical specificity is leveraged from vibrational spectroscopy, while light-matter interactions are detected by observing perturbations in the optical near field with an ato... |
41570415 | A Mn-incorporated porphyrinic metal-organic framework with near-infrared light responsive photothermal effect and intrinsic ROS scavenging ability for promoted healing of bacteria-infected wounds. | Photothermal nanomaterials constitute a promising platform for a broad spectrum of antimicrobial applications. However, the efficacy of photothermal therapy alone is often compromised by associated thermal stress, which elevates mitochondrial reactive oxygen species (ROS) production. The bacterial lysis can also releas... |
41565176 | Microbial fuel cell powered Fenton degradation of ciprofloxacin from wastewater employing MIL-88B(Fe)-MOF-laser-induced graphene cathode. | Traditional electro-Fenton (EF) is efficacious for antibiotics removal but faces challenges like high energy demand, operational cost and the use of homogeneous catalysts that lead to secondary pollution and sludge generation by iron leaching. Microbial fuel cell (MFC)-power-driven Fenton offers a sustainable and green... |
41561457 | Axially chiral thiophene scaffolds: configurational stability and circularly polarized luminescence. | A new type of axially chiral compound, 3,3'-bidithieno[2,3-<i>b</i>:3',2'-<i>d</i>]thiophene (BDTT), bearing aryl groups (BDTT-Ars) was synthesized and enantiomerically resolved. The racemization of enantiomers showed that their inversion barriers (Δ<i>G</i>) are in the range of 17.32-29.73 kcal mol<sup>-1</sup>. Among... |
41561146 | Correlated structural, vibrational and dielectric properties of the [(C<sub>4</sub>H<sub>9</sub>)<sub>4</sub>N]<sub>2</sub>CoBr<sub>4</sub> compound: origin of low-frequency polarization. | Organic-inorganic hybrid materials based on divalent metal halides constitute versatile platforms for tuning their physicochemical properties, with potential applications in optoelectronics, energy storage, and dielectric devices. Here, we present the first synthesis and complete characterization of [(C<sub>4</sub>H<su... |
41561013 | Electrochemically grown Cu,Ni-BTC film for the electrochemical detection of caffeic acid in fruits. | Caffeic acid (CA) is an important antioxidant often found in many kinds of fruits. In this study, we developed an electrochemical sensor based on an electrochemically grown bimetallic metal-organic framework film (Cu,Ni-BTC) for the <i>in situ</i> determination of CA in fruits. The Cu,Ni-BTC film was grown directly ont... |
41561007 | Effects of graphene oxide incorporation <i>via</i> non-covalent interfacial interactions on the properties of small intestinal submucosa. | To investigate the modifying effect of graphene oxide (GO) on small intestinal submucosa (SIS), GO-SIS biocomposite films were fabricated <i>via</i> a non-covalent coating strategy. Structural analyses confirmed the non-covalent interactions between GO and SIS collagen fibers and the preservation of SIS's native fibrou... |
41561008 | Polyoxometalate-ionic liquid functionalized magnetic nanocomposites for solid phase extraction and HPLC determination of sulfonamides in food samples. | Veterinary drug residues in animal-derived food products raise critical public health concerns, necessitating efficient extraction and detection methods to ensure food safety. In this study, novel Dawson-type polyoxometalate-ionic liquid (POM-IL) functionalized magnetic nanocomposites were synthesized for magnetic soli... |
41561006 | Microbial and molecular approaches for PFAS transformation in soils: prospects and limitations. | Microbial and enzymatic strategies for per- and polyfluoroalkyl substance (PFAS) transformation are receiving increasing attention, but remain at an early stage of scientific development. This review evaluates the limited but emerging evidence for microbially mediated PFAS transformation, the putative enzymes implicate... |
41561012 | Valorization of cash crop waste into a decomposable nanocellulose adsorbent matrix through bacterial cell factories for the management of agricultural runoff contaminants. | Agricultural runoff remains a pressing environmental concern, driven by the widespread use of herbicides and antibiotics in farming systems. In response, this study introduces a dual-purpose strategy that not only mitigates farming pollutants but also valorizes agro-industrial waste. Waste sugarcane molasses (WSM), an ... |
41561010 | Synthesis and binding studies of two new coumarin-squaramide-based receptors for NSAIDs. | Two new squaramide-based receptors containing coumarin units have been synthesized and characterized in both solution and solid states. L1 (3-(benzylamino)-4-((2-oxo-4-(trifluoromethyl)-2<i>H</i>-chromen-7-yl)amino)cyclobut-3-ene-1,2-dione) is a linear molecule, while L2 (4,4'-((1,3-phenylenebis(methylene))bis(azanediy... |
41561011 | Thermo-responsive polysulfobetaine beads crosslinked with biodegradable alginates for controlled release of agricultural pesticide. | The rise in global food demand and the loss in crop production by pests highlight the need for efficient pesticide delivery systems. Stimuli-responsive degradation with thermoresponsive polymers is a promising platform that offers the controlled release of pesticides. Here, we report the development of millimeter-sized... |
41561002 | An overview on emerging green organic corrosion inhibitors: sustainable solution for oil and gas industrial applications. | Corrosion remains a significant challenge across various industrial sectors, resulting in substantial economic losses, environmental hazards, and safety risks. Traditional corrosion inhibitors, though effective, often pose toxicity and environmental concerns, prompting the need for sustainable alternatives. The demand ... |
41560992 | Exploring the interplay of electron density distribution and electrostatic potential in the interaction of nilutamide and flutamide with androgen receptors using quantum crystallography. | Prostate cancer is a malignant disease commonly found in men. Androgens support the growth and survival of prostate cancer cells. To control this growth and the spread of cancer cells, anti-androgen drugs are necessary to block androgen activity. Effective blocking of androgens depends mainly on the structure, intermol... |
41558479 | Bacterial metabolites induce cell wall remodeling, antifungal resistance, and immune recognition of commensal fungi. | The fungus Candida albicans commensally colonizes mucosal surfaces in healthy individuals but can cause both superficial mucosal and life-threatening disseminated infections. The balance between commensalism and pathogenicity is complex and depends on factors including host and fungal genetic background, the host envir... |
41558439 | In situ growth of 2D nanosheets of terbium-based metal organic frameworks as super-hydrophilic and super-oleophobic (underwater) selective layer on a ceramic support for efficient separation of stabilized oil-in-water emulsion. | The current study aimed to develop an active layer composed solely of 2-dimensional nanosheets of terbium-based metal organic frameworks (Tb-IPA-NH<sub>2</sub> MOFs) on a ceramic support via an in situ growth approach. The ultimate aim of the current study was to develop a stable, defect-free active layer composed of 2... |
41555778 | Advancements in development of novel class of HIV protease inhibitors. | <h4>Background</h4>Protease (PR) inhibitors (PIs) are widely regarded as the most significant agents in the treatment of human immunodeficiency virus (HIV) and have been instrumental in the success of highly active antiretroviral therapy (HAART). The PR enzyme is essential for the viral life cycle, as it cleaves variou... |
41555740 | An Orthogonal Electronic State View on Charge Delocalization and Transfer. | We present a configuration interaction (CI) framework in which the electronic Hamiltonian is expressed in a basis of charge-localized determinants. This is used to independently generate adiabatic CI states and charge-localized CI states, both of which are unambiguously defined through a diagonalization procedure. The ... |
41555733 | Dynamic Slide-Ring Hydrogels with Dityrosine-Driven pH-Responsive Fluorescence: Enabling 3D Printing, Enhanced Drug Delivery and Regenerative Therapy. | The development of intelligent hydrogels with multifunctional capabilities holds great promise for advancing medical applications. In this work, we developed a dynamic slide-ring supramolecular hydrogel with dual molecular innovations: a dityrosine (DY)-driven pH-responsive fluorescence core in four-arm PEG (4A-PD) and... |
41555630 | Dynamic Microinterfacial Polymerization Enables Scalable Synthesis of Two-Dimensional Polymer Sheets for Quasi-Solid-State Electrolytes in Sodium-Metal Batteries. | Organic two-dimensional (2D) materials hold great potential in a broad range of applications. However, their practical utility is constrained by limited structural diversity and a lack of synthetic strategies. Herein, we report that simply stirring immiscible solutions of poly(propylene glycol)bis(2-aminopropyl ether) ... |
41555594 | Insights into the Controlled Formation of Zr-Based Metal-Organic Gels: Linking Macroscopic Properties with Molecular Information from Solution State NMR. | Understanding and controlling the formation mechanisms of metal-organic gels is crucial for their rational design with well-defined properties for diverse applications. However, rapid methodologies enabling atomic-resolution structural characterization of gel formation are still largely lacking. Here, we report for the... |
41555551 | Modulation of Carbon Nitride Using Supramolecular Self-Assembly for Facilitating Photocatalytic Seawater Hydrogen Production. | Solar-driven photocatalytic seawater splitting for hydrogen production represents a crucial green technology pathway for achieving a sustainable energy supply. In this study, a series of tremella-like porous graphitic carbon nitride photocatalysts (CNC-<i>x</i>) were constructed via a supramolecular self-assembly strat... |
41555543 | Investigation of exercise-mimetic bioactive molecules as modulators of MMP activity and expression in cancer cells. | Matrix metalloproteinases (MMPs), particularly MMP-2 and MMP-9, are directly involved in the degradation of the extracellular matrix preceding uncontrolled cancer growth and metastasis. For these reasons, MMPs are considered key therapeutic targets in the development of cancer treatments. Acknowledged for its prophylac... |
41555435 | Interleukin-16 upregulates tissue inhibitor of metalloproteinase 3 to promote atherosclerotic plaque stability. | <h4>Background</h4>High levels of circulating interleukin (IL)-16 are associated with a reduced incidence of cardiovascular events. The disruption of atherosclerotic plaques commonly causes myocardial infarction and stroke. In this study, we investigated the effects of IL-16 on phenotypic modification of plaques.<h4>Me... |
41555413 | Cerium-doped prussian blue nanozymes for bone regeneration and osteoprotection by Lhx2 in sutural distraction osteogenesis through multi-omics analysis. | Sutural distraction osteogenesis (SDO) involves the induction of new bone formation in the suture region through external distraction, widely employed for treating craniomaxillofacial deformities such as craniosynostosis and maxillary transverse hypoplasia. Nonetheless, there remains a deficiency in effective and minim... |
41555370 | Zn<sup>2+</sup>-mediated siRNA-doxorubicin self-assembled nanoparticles amplify Immunogenic cell death via aggravating redox dyshomeostasis for cancer therapy. | Immunogenic cell death (ICD), instigated by reactive oxygen species (ROS), has emerged as an efficacious strategy for augmenting the immunogenicity of tumor cells. However, the effects of ICD are severely diminished by elevated levels of glutathione (GSH) within tumor cells to maintaining intracellular redox homeostasi... |
41555323 | The impact of the pilot reform of home and community-based elderly care services on the health of the elderly. | <h4>Background</h4>The Home and Community-based Elderly Care Services (HCBS) pilot aims to improve access to preventive, rehabilitative, and long-term care for a rapidly ageing population. This study estimates the effect of HCBS on elderly mental and functional health and examines mechanisms and distributional heteroge... |
41554751 | G9a-mediated H3K9me2 orchestrates intestinal epithelial regeneration through epigenetic silencing of cell cycle-related genes. | Histone modifications play an important role in intestinal homeostasis and regeneration. Here, we identify histone H3 lysine 9 di-methylation (H3K9me2) as an epigenetic regulator of intestinal epithelial repair through mass spectrometry-based screening of histone modifications. We then find that H3K9me2 and its methylt... |
41554743 | Disruption of iron homeostasis sensitizes pancreatic cancer to irreversible electroporation. | Irreversible electroporation (IRE) is an ablative treatment for pancreatic cancer. It utilizes high-intensity pulsed electric field (PEF) to eliminate cancer cells by irreversibly disrupting cell membranes. However, PEF intensity is distributed unevenly; and cancer cells may survive in regions where it falls below the ... |
41554727 | Interfacial evaporation-induced localized multi-field coupling enables efficient co-recovery of freshwater and nitrates. | Recovering nitrate from surface water can help address interconnected environmental, resource, and energy challenges. In response, we have developed a bioinspired photothermal evaporation platform (BPEP) for the efficient co-recovery of low-concentration nitrate and freshwater. Through the evaporation-induced localized... |
41554006 | Curcumin/β-cyclodextrin complex-loaded porous microneedles with enhanced mechanical properties for infected wound healing. | Porous microneedles (PMNs) can efficiently load drugs via capillary action within their porous structure and enable controlled drug release in deep wound layers, thereby significantly promoting wound healing. However, increasing the porosity of PMNs typically compromises mechanical strength, leading to needle tip defor... |
41553850 | Proteomics Study of Breast Cancer-Derived Small Extracellular Vesicles: Unveiling Potential Cancer Biomarkers. | Small extracellular vesicles (sEVs) are lipid-bilayer-enclosed vesicles secreted by cells into the extracellular environment, carrying a variety of biomolecules, including proteins that reflect the molecular profile of their cell of origin. In particular, cancer-derived sEVs hold significant potential for cancer diagno... |
41553836 | Tunable Nanoscale Structure via Divalent Ion Identity in Charged-Neutral Polymer Blends. | Charged-neutral polymer blends, wherein an ion-containing polymer is blended with a neutral polymer, are potential candidates for battery electrolytes due to their improved ion transport properties and electrochemical stability. Though electrostatic interactions in charged polymer blends can theoretically stabilize ord... |
41553835 | Multiple-Site Engineered Metal-Organic Frameworks for Efficient One-Step Separation of Methanol-to-Olefin Products and Natural Gas. | Efficient one-step adsorption separation of light hydrocarbons (LHs) from methanol-to-olefin products and natural gas is highly desirable in the petrochemical industry. However, designing adsorbents that simultaneously achieve high selectivity and capacity remains a critical challenge. Here, we report a microporous Zn-... |
41553664 | Novel Thermostable α-Amylase from Bacillus subtilis: Molecular Characterization, Optimization, and Docking-Based Substrate Profiling. | Bacterial alpha-amylases have diverse industrial applications in food, fermentation, and pharmaceuticals. This study focuses on the isolation and characterization of a novel alpha-amylase-producing bacterium through molecular and in silico analyses, including molecular docking to determine enzyme-substrate specificity ... |
41553617 | Diosgenin-mediated NF-κB and MAPK pathway modulation for osteoarthritis treatment: molecular mechanisms, bioavailability enhancement, and therapeutic applications. | The review has comprehensively examined the therapeutic potential of phytoconstituents in the treatment of arthritis with specific emphasis being given to diosgenin as a promising natural molecule. Arthritis is a significant health concern in the world, with its two most common types; Osteoarthritis and rheumatoid arth... |
41553488 | IbMYB1-4 positively regulates purple stem and influences leaf color via dosage effect of gene expression in sweetpotato (Ipomoea batatas (L.) Lam.). | In sweetpotato, the quantitative variation of anthocyanin accumulation produces a continuous color spectrum that underpins both ornamental appeal and nutritional quality across cultivar species. Although previous studies have established that the expression of IbMYB1 is essential for purple pigmentation in germplasm, t... |
41553297 | A Chemoenzymatic Method To Systematically Quantify Core Fucosylation Stoichiometry of Glycoproteins and Reveal Its Roles in EMT and Embryonic Development. | Core fucosylation of N-glycoproteins plays pivotal roles in regulating many cellular events such as receptor-ligand binding and cell adhesion. Here, we developed a chemoenzymatic method combining selective enrichment, enzymatic reactions, and multiplexed proteomics to systematically quantify the core fucosylation stoic... |
41553255 | Designing for Dispersibility: How Crystallinity and Solubilizing Groups Affect Quantum Dot Dispersion in Diphenylhexatriene Matrices. | Nanocomposite films combining organic semiconductors (OSCs) and colloidal quantum dots (QDs) are promising systems for next-generation optoelectronic technologies such as singlet-fission photon multiplication (SF-PM). Here, we show that tuning the solubilizing substituents on the high-triplet-energy SF-OSC (1<i>E</i>,3... |
41553245 | Delocalization versus Coherence under Vibrational and Environmental Disorder in Photoexcited Supramolecular Aggregates. | Exciton and charge dynamics in photoexcited molecular materials depend critically on how delocalization competes with structural, vibrational, and environmental disorder. Yet, the origin and extent of coherent versus incoherent distribution of excitons and charges in such "noisy" supramolecular systems remain poorly un... |
41553133 | From Cloudy to Clear: A Strategy to Resolve the Complex Structural Elucidation of Bicycle Drug Conjugate Zelenectide Pevedotin by NMR. | Zelenectide pevedotin is a Nectin-4 targeting Bicycle drug conjugate® (BDC®) that has fast track designation for the treatment of bladder, breast, and lung cancers. Its structure is highly complex and comprises a Bicycle connected to microtubule inhibitor monomethyl aurostatin-E (MMAE) via a molecular spacer and a clea... |
41553112 | Atomically Precise Iron Catalysis for Efficient Electrochemical Cycloaddition of CO<sub>2</sub> With Low-Cost Feedstocks to Styrene Carbonate. | Electrocatalytic CO<sub>2</sub> cycloaddition provides a green route for the synthesis of cyclic carbonates under mild conditions. However, activating sterically hindered styrene oxide (SO) remains challenging due to its weak electron-withdrawing phenyl group. Herein, we report an atomically dispersed Fe/N-C single-ato... |
41553111 | Eco-Friendly Synthesis and Mechanistic Exploration of Multifunctional Cu/Cr Self-Assemblies for Durable and High-Performance Fuel Cell Composite Membranes. | Designing durable and high-performance proton exchange membranes (PEMs) remains a critical challenge for advancing polymer electrolyte membrane fuel cells (PEMFCs). In this study, we exploit the distinct coordination chemistries of Cu(II) and Cr(III) to construct multifunctional macromolecular self-assemblies of aspart... |
41553115 | Supramolecular Interlocking Produces Mechanically Anisotropic, Robust, and Tough Biomimetic Ionogels. | Ionogels have garnered significant attention in various cutting-edge fields due to their tunable mechanical properties and remarkable multifunctionality. However, current ionogels still struggle to achieve a combination of mechanical robustness and tissue-like anisotropy, hindering their application in next-generation ... |
41553099 | Polydopamine-Mediated Grafting of Cationic Polymer Brushes for Adsorption of Fluorinated Compounds. | Understanding the adsorption behavior of charged molecular species at functionalized polymer interfaces is critical for advancing surface science and material design. Building upon recent advances in polydopamine (PDA)-mediated polymer grafting, we investigated electrostatic adsorption at cationic polymer brush surface... |
41553088 | Defect-Passivating and Dense Indolocarbazole-Based Self-Assembled Monolayers for Efficient Inverted Perovskite Solar Cells With over 26.1% Efficiency. | Self-assembled monolayers (SAMs) are widely used in NiO<sub>x</sub>-based inverted perovskite solar cells (PSCs). However, the poor wettability, low surface coverage, inhomogeneous distribution, and inadequate defect passivation capability of SAMs limit further improvements in the efficiency and stability of IPSCs. Her... |
41553069 | New Hybrid Nanocomposite Films for Optical Diagnostics and Optical Temperature Sensing: Synergy Among α-Synuclein, Gold and Upconverting Nanoparticles. | The propensity of the unstructured protein α-synuclein to undergo a conformational transition to fibrillar aggregates was harnessed to prepare an upconverting organic-inorganic hybrid film composed of Au nanoparticles (NPs) and Yb<sup>3+</sup>, Er<sup>3+</sup>-activated CaF<sub>2</sub> NPs, with α-synuclein serving as ... |
41553049 | Synthesis and Self-Assembly of Perylene Imide-Containing Hydrophilic Polymers in Water. | New advances in synthetic strategies have greatly expanded the structural diversity of perylene imides (PIs), increasing the tunability of their molecular properties and assemblies in organic solvents. More recent studies also show molecular assemblies in aqueous media when the hydrophobic perylene core is functionaliz... |
41553029 | Comparative Analysis of Oral Hypofunction in Community-Dwelling Adults in Japan and Clinic-Recruited Community-Dwelling Adults in Switzerland: A Cross-Sectional Study. | <h4>Background</h4>Oral hypofunction (OHF) is a multidimensional condition representing a subclinical decline in oral function. Cross-national comparisons using standardised criteria remain limited.<h4>Objectives</h4>This study aimed to compare the prevalence and characteristics of OHF among community-dwelling adults i... |
41552982 | Highly Connected Stable Metal-Organic Frameworks With Polyhedral Cage-Like Cavities for Natural Gas Upgrading. | The development of efficient methane (CH<sub>4</sub>) separation and purification technologies is essential for optimizing the efficiency of natural gas. Compared to conventional cryogenic distillation, adsorptive separation using porous materials offers significant advantages in terms of energy efficiency and operatio... |
41552975 | Advanced Molecular Tweezers Effectively Target Membranes Lacking Choline Headgroups for Broad-Spectrum Antiviral Efficacy. | Broad-spectrum antivirals are urgently required to counter present and emerging viral threats. It has previously been shown that the parental molecular tweezers CLR01 and CLR05 disrupt viral envelopes by complexing choline headgroups and that ester-functionalized "advanced" tweezers display markedly enhanced antiviral ... |
41552960 | High-Selective and Ultrafast Furfural Removal From Simulated Biomass Hydrolysates via a Sustainable MOF-Based Strategy. | The microbial fermentation efficiency of biomass-derived sugars into biofuels and bioplastics is severely hindered by inhibitory compounds such as furfural and 5-hydroxymethylfurfural generated during biomass hydrolysis, highlighting the urgent need for their selective and efficient removal. Herein, we report the desig... |
41552941 | Halochromic Benzazolo-oxazolidine/Polyoxometalate Supramolecular Materials with Reversible High-Contrast Color-Switching. | The first halochromic supramolecular ionic assemblies of a stimulus-responsive benzazolo-oxazolidine (BOX) derivative with polyoxometalates (POMs) have been elaborated. First, the conversion of the 7,9,9-trimethyl-10-(4-dimethylamino)styryl-indolino[2,1-<i>b</i>]oxazolidine (<b>3</b>) neutral ring-closed form to its mo... |
41552871 | Population-scale landscape of TE insertion polymorphisms reveal their roles in gene expression regulation, adaptation, and agronomic traits in Brassica napus. | Transposable elements (TEs) are abundant and evolutionarily important components of plant genomes, yet the population-scale landscape of TE insertion polymorphisms (TIPs) and their regulatory roles in gene expression and trait variation remain insufficiently understood. In this study, genomic resequencing, RNA-seq, and... |
41550029 | Early detection of banana fusarium wilt caused by Fusarium oxysporum f. sp. cubense using hyperspectral with a metric learning strategy. | <h4>Background</h4>Fusarium wilt of banana, caused by Fusarium oxysporum f. sp. cubense Tropical Race 4 (Foc TR4), poses a severe threat to global banana production. Early detection of this disease remains a major challenge, as infection is often widespread before visible symptoms appear. The identification of plants i... |
41549882 | Bioinspired Engineering of Living Materials to Reconstruct Stromal-Parenchymal Interactions for Post-Stroke Neural Regeneration. | Stroke remains a leading cause of neurological disability worldwide. A major obstacle to brain tissue regeneration after stroke is the persistent local inflammation and the absence of extracellular matrix (ECM) support within the infarct cavity, which severely impedes the brain's endogenous repair. Inspired by the natu... |
41549858 | Redefining Therapies for Drug-Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design. | Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a major global health concern, particularly due to the emergence of multidrug-resistant and extensively drug-resistant strains. The persistence and propagation of TB are favored by the pathogen's sophisticated virulence mechanisms, its ability to ev... |
41549710 | Self-Assembled (Aza)BODIPY Dyes for Biomedical in Vivo Imaging. | 4,4-difluoro-4-bora-3a,4a-diaza-s-indacenes (BODIPYs) and their N-containing analogs (aza-BODIPYs) are highly versatile organic dyes that combine excellent photophysical, electronic, and supramolecular properties with high chemical stability. These features have enabled their use in diverse applications such as bioimag... |
41549087 | Controlled hierarchical self-assembly of hyperbolic paraboloid molecules into two-dimensional superstructures with second-harmonic generation characteristic. | Hyperbolic paraboloid molecules, as systems with remarkable negative Gaussian curvature, have garnered considerable attention in chemistry and materials science due to their unique physicochemical properties. However, controlled organization of these curvature building blocks into well-defined superstructures remains c... |
41548947 | Substituted 2-Phenyl Imidazolidines: Synthetic Strategies, Biological Activities, Mechanistic Insights, and Nanocarrier-Based Advancements. | Substituted 2-phenyl imidazolidines present a structurally diversified family of heterocycles with several medicinal potentials. Their significance is due mostly to the presence of the phenyl group at the C-2 position, which enhances lipophilicity, rigidity, electronic distribution, and molecular recognition. This revi... |
41384868 | Surface charge engineering enhances symmetry and reliability of nanopores formed <i>via</i> dielectric breakdown. | Achieving high geometric symmetry in solid-state nanopores is crucial for consistent signal response and molecular recognition. However, dielectric breakdown-based nanopore fabrication often yields asymmetric pore structures, particularly in thin membranes where local electric field fluctuations are pronounced. In this... |
41358958 | Precise <i>Klebsiella pneumoniae</i> carbapenem resistance prediction by Zn-Cu/MOF-embedded hybrid nanosheet-assisted carbapenemase activity analysis. | The global rise of carbapenemase-producing <i>Klebsiella pneumoniae</i> (CPKP) poses a major threat to public health due to its high morbidity and mortality rates, driven largely by the production of carbapenemase enzymes. Rapid and accurate detection of carbapenemase activity is crucial for guiding appropriate antimic... |
41332277 | The RNA-binding protein RNP1A is essential and interacts with contractility kit proteins to facilitate cell mechanics. | Cell shape regulation is important for many biological processes. Some cell shape-regulating proteins harbor mechanoresponsive properties that enable them to sense and respond to mechanical cues. In Dictyostelium discoideum, mechanoresponsive network proteins formed by proteins such as myosin II, cortexillin I and IQGA... |
41307230 | HA Protein acetylation modulates replication, pathogenicity, and immunogenicity of influenza virus and facilitates live-attenuated vaccine design. | Lysine acetylation, a form of protein post-translational modification (PTM), is known to play crucial roles in regulating cellular and physiological processes. In this study, for the first time, lysine acetylation sites were identified on the hemagglutinin (HA) protein of H1N1 subtype influenza virus using mass spectro... |
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