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41624172 | Fucoidan as a renal protectant: mechanistic insights and therapeutic implications of endothelial glycocalyx targeting. | The progression of chronic kidney disease (CKD) is closely associated with damage to the endothelial glycocalyx (eGC) of the renal microvasculature. The eGC, particularly its heparan sulfate (HS) components, is crucial for maintaining the charge-selective barrier and microenvironmental homeostasis. Modern pharmacologic... |
41623986 | Operational parameters and key characteristics of amino acids and flavor compounds profiles of bovine bone clear and white broths. | Emulsification was found to enhance the nutritional value and flavor of bovine bone broth, although the specific processing conditions and their impact on amino acid profiles and flavor compounds remained unclear. To address this knowledge gap, this study identified critical parameters for producing clear broth (simmer... |
41613967 | Enantioselective C-H functionalization: logic and applications in the total synthesis of natural products. | Natural products, with their profound structural diversity and potent bioactivities, represent an invaluable source of inspiration for drug discovery and biomaterial development. The integration of enantioselective C-H functionalization into synthetic planning has emerged as a transformative strategy, offering streamli... |
41600411 | Nanobiosensors: A Potential Tool to Decipher the Nexus Between SARS-CoV-2 Infection and Gut Dysbiosis. | The emergence of SARS-CoV-2 posed a great global threat and emphasized the urgent need for diagnostic tools that are rapid, reliable, sensitive and capable of real-time monitoring of SARS-CoV-2 infections. Recent investigations have identified a potential connection between SARS-CoV-2 infection and gut dysbiosis, highl... |
41599543 | Methanotrophic Poly(hydroxybutyrate) Through C1 Fermentation and Downstream Process Development: Molar Mass, Thermal and Mechanical Characterization. | Today, PHB and its copolymers-potential plastic substitutes-are produced by fermenting sugar, which is not scalable to the volumes of plastic consumption. PHB from CH<sub>4</sub> can offer a sustainable process route, with CH<sub>4</sub> potentially produced from a variety of waste biomass streams through anaerobic dig... |
41599542 | Correlation of Polymer-drug Composition with Micelle Properties, Performance, and Cytotoxicity for the Oligoelectrolyte-mediated pH-triggered Release of Hydrophobic Drugs. | Polymeric micelles have the potential to improve the efficacy and safety of drug delivery by improving drug solubility, enhancing bioaccumulation and reducing off-target toxicity. Despite excellent safety profiles, a major limitation with polymeric micelles is their inability to rapidly release their payload once they ... |
41599529 | Novel Bioinspired Quercetin-Based Polymers for the Sustained Release of Donepezil in Alzheimer's Disease Therapy. | This work was inspired by quercetin, a natural bioflavonoid with well-known neuroprotective properties. We synthesized a new functional monomer, 3-acryloxy-3',4',5,7-tetramethylquercetin <b>1</b>, and used it to prepare, for the first time, a molecularly imprinted polymer (MIP) selective for donepezil, the main drug us... |
41599362 | Synthesis of <i>N</i>-Difluoromethyl Benzothiazole (or Benzoxazole) Selenones as Novel Inhibitors Against Phytopathogenic Fungi. | Azole selenoureas exhibit diverse biological functions. However, the synthesis and biological activity of benzothiazole and benzoxazole selenones remained unexplored. Herein, we report the base-catalyzed synthesis of <i>N</i>-difluoromethyl benzothiazole (or benzoxazole) selenone derivatives, which demonstrated signifi... |
41599224 | β-Cyclodextrin Inclusion Complexes of <i>Cinnamomum camphora</i> Essential Oil: A Comparative Study on Encapsulation Strategies, Physicochemical Stability, and Cytotoxic Profile. | <b>Background/Objectives</b>: Essential oils (EOs) from plants of the genus <i>Cinnamomum</i> have been widely used based on their antimicrobial, antioxidant, and anti-inflammatory properties. However, their elevated volatility and limited aqueous solubility restrict their use in pharmaceutical and food formulations. C... |
41598077 | Polarity-Driven Selective Adsorption of Quercetin on Kaolinite: An Integrated DFT and Monte Carlo Study. | Quercetin's therapeutic potential is limited by its poor water solubility and rapid degradation. Natural clay minerals such as kaolinite present sustainable platforms for drug delivery, yet the molecular mechanisms of drug encapsulation are not fully understood. Specifically, the role of kaolinite's structural polarity... |
41596936 | Effect of Additive Removal on the Physicochemical Properties of Gluten-Free Bread. | The growing demand for clean-label gluten-free bread is driving a reduction in additives, although their technological roles are not yet fully understood. This study evaluated the effect of progressively removing monocalcium phosphate, sodium bicarbonate, and mono- and diglycerides (MDG) on the quality of gluten-free b... |
41596927 | Effect of Prolonged Frozen Storage on the In Vitro Digestion of Minced Pork: Insights from Protein Structural Changes. | Long-term frozen storage is widely used for pork preservation, yet its impact on protein digestibility remains inadequately explored. This study investigated the effect of frozen storage duration (0, 3, and 12 months) on the changes in digestive properties and protein structure of minced pork during in vitro digestion.... |
41596562 | Enhancing the Water Solubility and Efficacy of Anticancer Drugs Using Hydroxypropyl-β-Cyclodextrin. | Cyclodextrins (CyDs) are cyclic oligosaccharides that form inclusion complexes that allow organic compounds and other substances to be incorporated into their cavities. Hydroxypropyl-β-cyclodextrin (HP-β-CyD) is frequently used to improve the formulation properties of poorly water-soluble drugs because of its aqueous s... |
41596553 | Neuroprotection in Diabetes Retinal Disease: An Unmet Medical Need. | Diabetic retinopathy (DR) has been classically considered a microvascular disease with all diagnostic and therapeutic resources focusing on its vascular components. However, during the past years, the obtained evidence highlighted the critical pathogenic role of early neuronal impairment redefining DR as a neurovascula... |
41596558 | Crocins Ameliorate Experimental Immune Checkpoint Inhibitor-Related Myocarditis by Targeting the Hpx/Nrf2/HO-1 Pathway. | Immune checkpoint inhibitors (ICIs) for cancer therapy may induce immune-related adverse events including myocarditis, which occurs infrequently but carries a high mortality rate. Crocins are the active constituents derived from <i>Crocus sativus</i> L. (saffron), and have demonstrated various bioactivities including a... |
41596041 | bFGF-Loaded PDA Microparticles Enhance Vascularization of Engineered Skin with a Concomitant Increase in Leukocyte Recruitment. | Engineered skin (ES) can serve as an advanced therapy for treatment of large full-thickness wounds, but delayed vascularization can cause ischemia, necrosis, and graft failure. To accelerate ES vascularization, this study assessed incorporation of polydopamine (PDA) microparticles loaded with different concentrations o... |
41594273 | Development of Functional Performance, Bone Mineral Density, and Back Pain Under Specific Pharmacological Osteoporosis Therapy in an Elderly, Multimorbid Cohort. | <b>Background/Objectives:</b> Specific pharmacological osteoporosis therapy (SPOT) is regarded as a key intervention to reduce fracture risk and improve musculoskeletal function. Real-life data, particularly regarding functional muscular outcomes and pain trajectories, remain limited. This study aimed to longitudinally... |
41591192 | Functional Dissection of <i>Leishmania major</i> Membrane Components in Resistance to Cholesterol-Dependent Cytolysins. | Bacteria use cholesterol-dependent cytolysins (CDCs) to damage eukaryotes. While well-studied in mammals, the mechanisms by which CDCs bind to and kill protozoans remain unclear. CDCs bind to the human pathogen <i>Leishmania major</i> but only kill in the absence of sphingolipids. The contribution of other leishmanial ... |
41591037 | Fluorescent Nanoporous Gene Drugs with Fenton-like Catalysis Vector Research. | A multifunctional diagnosis and treatment carrier, ZIF-8@CDs, based on carbon quantum dots (CDs) and the zeolitic imidazolate framework-8 (ZIF-8) metal-organic framework which serves as a core structure for constructing the responsive delivery platform, is developed in this paper. The anticancer drug doxorubicin (DOX) ... |
41590596 | Protocol for Engineered Compositional Asymmetry Within Nanodiscs. | Membrane proteins remain the most challenging targets for structural characterization, yet their elucidation provides valuable insights into protein function, disease mechanisms, and drug specificity. Structural biology platforms have advanced rapidly in recent years, notably through the development and implementation ... |
41590484 | A One Health Perspective on <i>Aspergillus fumigatus</i> in Brazilian Dry Foods: High Genetic Diversity and Azole Susceptibility. | <i>Aspergillus fumigatus</i>, a saprophytic fungus, causes aspergillosis, primarily affecting the immunocompromised. The efficacy of triazole antifungals is compromised by resistance that has developed both clinically and environmentally. Widespread agricultural use of similar triazole fungicides selects for resistant ... |
41590316 | Yeast Biosensors for the Safety of Fermented Beverages. | Yeast biosensors represent a promising biotechnological innovation for ensuring the safety and quality of fermented beverages such as beer, wine, and kombucha. These biosensors employ genetically engineered yeast strains to detect specific contaminants, spoilage organisms, or hazardous compounds during fermentation or ... |
41590104 | Molecularly Engineered Aza-Crown Ether Functionalized Sodium Alginate Aerogels for Highly Selective and Sustainable Cu<sup>2+</sup> Removal. | Developing sustainable and molecularly selective adsorbents for heavy-metal removal remains a critical challenge in water purification. Herein, we report a green molecular-engineering approach for fabricating aza-crown ether functionalized sodium alginate aerogels (ACSA) capable of highly selective Cu<sup>2+</sup> capt... |
41590105 | Emerging Gel Technologies for Atherosclerosis Research and Intervention. | Atherosclerosis remains a leading cause of cardiovascular mortality despite advances in pharmacological and interventional therapies. Current treatment approaches face limitations including systemic side effects, inadequate local drug delivery, and restenosis following vascular interventions. Gel-based technologies off... |
41590102 | Textural Properties of Carbopol<sup>®</sup> Gel with Curcumin and Curcumin-HPβCD Inclusion Complex and Biological Activities. | The aim of this study was to prepare curcumin/2-hydroxypropyl-β-cyclodextrin (HPβCD) inclusion complex, evaluate the antioxidant and antimicrobial activities of curcumin and curcumin in inclusion complex, as well as to examine the effect of curcumin and curcumin inclusion complex on the textural properties of Carbopol<... |
41589993 | Bioinspired Heat Exchangers: A Multi-Scale Review of Thermo-Hydraulic Performance Enhancement. | Heat exchangers are central to energy and process industries, yet performance is bounded by the trade-off between higher heat transfer and greater pressure drop. This review targets indirect-type heat exchangers and organizes bioinspired strategies through a multi-scale lens of surface, texture, and network scales. It ... |
41570716 | Plant volatiles-based supramolecular nanoassembly induced by guanidines for sustainable phytopathogen management. | Plant volatiles (PVs) are recognized as important mediators of plant interactions with the function of protecting against stress and inducing defense, which presents a potential resource to biopesticides for offering a sustainable and biosafe alternative to conventional agrochemicals. However, PVs exhibit limited bioav... |
41564536 | Enterococcus faecalis enhances growth and immunity in geese by modulating the jejunal microbiota and intestinal barrier. | The application of Enterococcus faecalis (E. faecalis) in goose farming has been increasing, and it has demonstrated significant efficacy in reducing the diarrhea rate, inhibiting the number of Escherichia coli, and improving production efficiency and feed utilization. This study aimed to explore the effects and mechan... |
41558091 | Electrochemical purification of a cobalt-catecholate framework to suppress non-radiative recombination boosts photocatalytic CO<sub>2</sub> reduction. | Photocatalytic CO<sub>2</sub> reduction represents a fundamental route for solar-to-fuel conversion, yet its efficiency is often limited by rapid non-radiative recombination of photogenerated charge carriers induced by intrinsic deep-level defects. While extrinsic modifications have been widely explored, the targeted e... |
41554214 | A "turn-off" fluorescent probe based on terbium doped Zn-MOF for sensitive detection of the food additives. | The overconsumption of food additives butylated hydroxyanisole (BHA) and acesulfame K (AK) may cause health hazards. Therefore, it is urgent to develop sensitive detection methods for them in food safety surveillance. This study reports the synthesis of terbium doped metal-organic framework material (Tb<sup>3+</sup>@Zn... |
41554199 | Development of portable and highly sensitive electrochemical sensor for rapid on-site analysis of levofloxacin residue in pork samples. | Levofloxacin is widely utilized as a livestock feed additive, yet its residues in animal-derived foods pose risks to human health. Herein, a portable and highly sensitive electrochemical sensor was developed for on-site levofloxacin detection in food of animal origin. The sensor employs facile electrochemical polymeriz... |
41551223 | Mechanistic Insights Into Protein Aggregation Inhibition by Green-Synthesized Silver Nanoparticles: A Study on Human Lysozyme. | A characteristic of many neurodegenerative disorders, such as Parkinson's and Alzheimer's, is amyloidogenic protein aggregation, for which there are currently no proven cures. Aging, mutation, and physiological stress can cause proteins to deviate from their natural folding patterns, potentially leading to the formatio... |
41550826 | A selective fluorescent probe for an organophosphorous nerve agent mimic <i>via</i> an oxime-to-isoxazole cascade reaction. | A class of chemical warfare agents and their facile use in terrorist attacks underscores the need to develop accurate system to detect these chemicals. For this paper, we synthesized and developed a new highly selective and sensitive fluorescence probe based on fluoresceinyloxime for the detection of a nerve agent mimi... |
41550828 | A high-copper-content metal-organic framework with potential antibacterial activities. | Despite recent significant advancements in antibacterial applications of copper-based metal-organic frameworks (Cu MOFs), the synthesis of a high-copper-content MOF remains elusive. Here we proposed a multi-coordination strategy through a direct solvothermal reaction of Cu ions and formic acid, which yielded a three-di... |
41550820 | Molecular insights into the oil-in-water emulsification and demulsification of guanidino-based CO<sub>2</sub>/N<sub>2</sub> switchable surfactants. | CO<sub>2</sub> switchable surfactants show broad application prospects in the treatment of oil-based drilling cuttings due to their reversible 'active-inactive' state switching characteristics. This study focuses on the typical guanidinium-based CO<sub>2</sub>-responsive surfactant dodecyl tetramethyl guanidine (DTMG) ... |
41550827 | Bioinspired super-tough polyurethane elastomers with block modules using sacrificial bonds. | Stretchable and self-healable elastomers with excellent mechanical properties can find attractive applications in electronic skin, soft robotics, and electrical devices. To date, it remains a huge challenge to synthesize self-healing elastomers that integrate extreme stretchability, relatively high toughness, and high ... |
41548848 | Technology for Nucleic Acid Delivery in the Treatment of Hematological Malignancies. | Blood (hematological) cancers display a wide spectrum of etiologies that can be attributed to specific molecular and chromosomal changes. While the uncontrolled proliferation of blood cells could be controlled to some degree by conventional anti-neoplastic agents, advanced therapies are needed to enhance the chances of... |
41548310 | Synergistic modulation of structural isomerism and intramolecular charge transfer in fluorescent probes for highly efficient and long-term ratiometric monitoring of the nerve agent simulant DCP. | The photoluminescence properties of fluorescent probes directly influence sensing performance, especially regarding distinct signal changes and high-contrast responses. Although the relationship between photoluminescence properties and molecular structure has been extensively explored, the connection among molecular st... |
41547353 | Multimodal supramolecular targeting chimeras enable spatiotemporally resolved protein degradation in vivo. | Targeted protein degradation (TPD) has transformed strategies for modulating protein function in both basic biology and therapeutic development. However, current strategies often lack the spatial and temporal precision required for in vivo applications. Herein, we report supramolecular targeting chimeras (SupTACs), a m... |
41547115 | Generation and characterisation of a humanised GLP-1 receptor mouse model for translational drug development. | <h4>Background</h4>Injectable peptide-based glucagon-like peptide-1 receptor (GLP1R) agonists (GLP1RAs) are effective treatments for obesity and diabetes but are limited by patient compliance and scalability challenges. In contrast, non-peptide small-molecule GLP1RAs offer the advantage of oral delivery but are relativ... |
41546410 | Dynamic H-Bonding Mediates Stimuli-Responsive Chiral Induction in Porous Aromatic Cages with Multicolor Chiral Afterglow. | The origin of biological chirality remains a fundamental scientific mystery. Developing artificial systems with on-off responsive chiral induction and transfer, and elucidating their mechanisms, is of paramount importance. Here, we report the first pair of chiral porous organic cage (R/S-BA-PAC) exhibiting unprecedente... |
41546418 | Facet-Selective Nucleation Control for Constructing Multi-Dimensional MOFs Heterostructures. | Metal-organic framework (MOF) heterostructures featuring tunable morphologies and compositions have shown great promise for applications in high-throughput sensing, anti-counterfeiting, and information encryption. Nevertheless, the precise engineering of heterogeneous architectures with multi-dimensional building units... |
41546416 | DNA Origami-Templated Aptamer Chiral Structures Realize Cellular Enantioselectivity. | Chirality refers to handedness as left- or right-handed form of a molecule or molecular construct by synthesis or self-assembly. In biology, chirality plays critical roles in determining the structures and functions of biomolecules such as proteins. In this study, we demonstrated that structural chirality generated by ... |
41546404 | Acid-Stable Ruthenium-Based Solid Solution for Oxygen Evolution in Proton Exchange Membrane Electrolyzers. | Proton exchange membrane (PEM) water electrolysis offers a promising route for green hydrogen production, yet balancing catalytic activity and durability remains challenging for oxygen evolution reaction (OER) catalysts in acid, particularly for non-Ir-based catalysts. Herein, we develop a template-guided strategy to s... |
41546399 | Stiffness-Gated Cytoplasmic mRNA Delivery Through Engineered Membrane Fusion for Breast Cancer Immunotherapy. | Traditional lipid nanoparticles (LNPs) suffer from low lysosomal escape efficiency (<4%) and off-target toxicity, hindering mRNA therapy translation. While membrane fusion carriers bypass endosomal entrapment, their lack of cell specificity induces non-target cytotoxicity. To overcome these limitations, we developed a ... |
41546161 | Interfacing and Growth Pathways of Metal-Organic Frameworks with Morphological Evolution. | Hybrid metal-organic frameworks (MOFs) that integrate multiple components or structures via MOF-on-MOF growth offer promising avenues for constructing highly valued MOFs. However, understanding and controlling the anisotropic MOF-on-MOF growth that occurs between MOFs with mismatched lattices remain challenging, partic... |
41546160 | Programmable Nanoscale Motion via Molecular Patterning on DNA Origami. | Asymmetry in enzymatically driven nanomotor design, both structural and functional, is widely considered essential for propulsion. However, the interplay between particle geometry, enzyme distribution, and catalytic loading remains poorly defined, largely due to limited control over enzyme positioning that hinders quan... |
41546122 | Ai derivation and exploration of antibiotic class spaces. | <h4>Purpose</h4>The rapid evolution of antibiotic-resistant bacteria poses an urgent global health crisis. A key gap in current antibiotic discovery approaches is the absence of automated chemical synthesis methods designed to systematically generate and evaluate compounds within specific antibiotic classes. We address... |
41546096 | A programmable peptide interface for on-demand neural culturing platforms. | The precise spatial organization of neural cells into two-dimensional networks or three-dimensional spheroids is crucial for advancing neuroscience research and drug discoveries, yet remains challenging with conventional, single-function coatings. Here, we propose a programmable bifunctional peptide that integrates a s... |
41545875 | Antifungal activity of oily core PEGylated PLGA nanocapsules loaded with Penicillium oxalicum fungal extract: in vitro, in vivo, and in silico study. | The rise of difficult-to-treat fungal infections necessitates novel therapeutic strategies. In this study, endophytic fungi were isolated from Acalypha hispida leaves and molecularly identified as Penicillium oxalicum via 18S rRNA sequencing. LC-MS/MS analysis of the fungal extract revealed major bioactive compounds, i... |
41545503 | Breaking the oxo-wall for Co(IV)-oxo species and their nanoconfined catalytic performance within Ce-Co lamellar membrane. | Co(IV) = O-mediated Fenton-like processes show great potential for water remediation but are fundamentally limited by the "oxo-wall" effect, which imposes prohibitive activation energies for Co(IV) = O bond formation and stabilization. Herein, by unifying thermodynamic analysis with the "oxo-wall" constraint mechanism,... |
41545457 | Cascading chirality from molecule to twisted microstructures with amplified circularly polarized luminescence. | Control of chiral assembly across length scales is desirable but challenging. Herein, we demonstrate controllable construction of microscopic chiral twists through hierarchical assembly of enantiomeric styrylpyridinium-derived glutamide amphiphiles (L/D-SPG). By combining variable-temperature spectroscopy with in-situ ... |
41545444 | Structural divergence of lentinula edodes polysaccharides is associated with distinct anti-hyperuricemia pathways. | Lentinula edodes (L. edodes) polysaccharides hold therapeutic potential for hyperuricemia (HUA), but their mechanisms remain unclear. This study investigated the anti-HUA effects and associated regulatory pathways of two structurally distinct polysaccharides (LEP20 and LEP50) from L. edodes. Structural analysis identif... |
41545427 | An artificial cell capable of signal transduction mediated by ADRB2 for the regulation of glycogenolysis. | Bottom-up construction of artificial cells helps elucidate the working mechanism of cells. Signal transduction from extracellular to intracellular artificial cells is essential for autonomous artificial cells. It remains highly challenging to reconstitute G protein-coupled receptor (GPCR) signaling pathways to regulate... |
41545420 | Heterologous immunization modulates B-cell epitope competition between helper peptides and the MPER segment in MPER/liposome vaccines. | Subdominant B-cell immune responses to conserved epitopes are major obstacles in eliciting broadly neutralizing antibodies (bnAbs) against HIV-1 through natural infection or vaccination. Although the sequence conserved membrane proximal external region (MPER) of HIV-1 gp41 is partially occluded on the virion surface, e... |
41545417 | In silico design of a multi-epitope vaccine targeting DENV-1 and DENV-3. | The co-infection of DENV-1 and DENV-3 during endemic outbreaks can be potentially fatal and complicate the diagnostic process. In our study, we have focused on the development of a multiepitope vaccine against DENV-1 and DENV-3 co-infection, utilizing non-structural protein 1 (NS1) and envelope protein (E) as key antig... |
41545407 | Molecular basis of antagonism of the dimeric human arginine vasopressin receptor 1A. | Arginine vasopressin (AVP) and oxytocin (OT) are peptide hormones critical for various physiological processes. Vasopressin receptor 1 A (V1aR), a primary AVP target, is promising for central nervous system (CNS) disorders therapies, yet the mechanisms of antagonism and oligomerization remain poorly understood. Here, w... |
41545397 | Composite P3HT/ZnO thin films via FTM for improved charge transport in OFETs. | Zinc oxide (ZnO) nanorods, measuring 500 nm in diameter and 100 nm in length, were created in this article using an optimised hydrothermal low temperature technique. Using the newly created floating film transfer method, a large-scale oriented composite thin film of ZnO nanorod dispersion and poly (3-hexyl thiophene) i... |
41545371 | Advances, challenges and prospects of origami and kirigami optoelectronics. | Switchable between 2D and 3D forms, origami and kirigami have emerged as a versatile platform for deformable optoelectronic devices. Unlike electronic devices, whose electrical properties remain largely unchanged during transformation, the optoelectronic properties of these systems can vary significantly, offering oppo... |
41545374 | Reticulating node-linker-modulator chemical spaces for modular design of alkoxide-based glasses and liquids. | Glasses linked by molecular building blocks are emerging materials promising for combining the processability of glasses and designability of reticular frameworks. Achieving modular chemical space construction is key to promoting structural diversity for these glasses, which requires systematically understanding their ... |
41545361 | Mechanism of trans-envelope bacterial polysaccharide secretion in Class-3 outer-membrane polysaccharide export (OPX) protein systems. | Bacterial secretion of extracellular polysaccharides is essential for surface colonization, biofilm formation, and pathogenesis. In diderm bacteria, such polymers traverse the periplasm and outer membrane (OM) through outer-membrane polysaccharide export (OPX) proteins that form secretion pores. Among them, Class-3 OPX... |
41545340 | Metabolic dysfunction-associated steatotic liver disease accelerates pancreatic cancer progression and metastasis via the macrophage migration inhibitory factor-CD44 axis. | Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a poor prognosis, particularly in the presence of liver metastases. The mechanisms by which metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD), influences PDAC progres... |
41545330 | Unraveling Topology-Driven Flexibility in Chlorinated Zeolitic Imidazolate Frameworks under CO<sub>2</sub> Pressure Using Experimental and Simulations Study. | Gas-framework interaction-induced flexibility of zeolitic imidazolate frameworks (ZIFs) is of paramount interest as it enhances the gas adsorption capacity and can also be exploited to fine-tune the gas separation selectivity of ZIFs. The gas-framework interaction-induced lattice expansion or linker-twisting leading to... |
41545192 | Deconstruction by <i>C. thermocellum</i>-from microbe mediated to dynamic redistribution of cellulosomes. | <i>Clostridium thermocellum</i> is one of the most efficient microorganisms for the deconstruction of cellulosic biomass. To achieve this high level of cellulolytic activity, <i>C. thermocellum</i> uses large multienzyme complexes known as cellulosomes to break down complex polysaccharides, notably cellulose, found in ... |
41544234 | Material-Independent Film Formation of Zr<sup>4<b>+</b></sup>-Trimesic Acid Metal-Organic Complexes and Their Antifouling Applications. | Interface-active, metal-organic complexes (MOCs) have been extensively exploited for interface engineering due to their material-independent coating properties. However, the MOC-based films often face some challenges, such as dark coloration and synthetic difficulty in organic-ligand derivatives, limiting their functio... |
41544180 | Tuning the Photoelectrochemical Properties of Ti/W-Modified PCN-222 Using Charge-Selective Interfaces. | Metal-organic frameworks (MOFs) have attracted growing interest for photoelectrochemical (PEC) applications, including visible-light photocatalysis, CO<sub>2</sub> reduction, and hydrogen evolution, owing to their structural tunability and hybrid inorganic-organic nature. The Zr-based porphyrinic framework PCN-222 comb... |
41544168 | A causal coding variant regulating alternative splicing of <i>DOC2A</i> at 16p.11.2 GWAS locus influences susceptibility to schizophrenia. | Although genome-wide association studies (GWASs) have identified many schizophrenia-associated variants, their biological mechanisms remain unclear. Using transcriptomic data from human brain tissues, we performed splicing quantitative trait locus (sQTL) analyses of schizophrenia-associated single-nucleotide polymorphi... |
41544165 | Crotonate suppresses breast cancer metastasis and promotes immunotherapy response by inducing ACSS2-mediated EZH2-K348 crotonylation. | Crotonate, a short-chain fatty acid, generates protein crotonylation. However, the role of crotonate in cancer progression is unknown. Here, we present a crotonate-crotonyl-coenzyme A (CoA)-enhancer of zeste homolog 2 (EZH2) crotonylation cascade blocking breast cancer growth and metastasis. We demonstrated that croton... |
41544160 | Cell surface engineering with a pseudofibrotic ECM reprograms the antifibrotic activity of mesenchymal stromal cells. | Fibrotic diseases, which impair tissue function and contribute to organ failure, remain a major clinical challenge with limited treatment options. Mesenchymal stromal cells (MSCs) offer promise for antifibrotic therapy via paracrine signaling, but their clinical efficacy is hindered by poor survival and limited functio... |
41544155 | Perovskite nanocrystals-in-glass hierarchical structures enable stable continuous-wave random lasers. | Encapsulating perovskite nanocrystals (PNCs) in glass enables enhanced stability of PNCs and numerous applications such as random lasers. However, preparing PNCs and tuning their properties in glass is energy consuming because of high processing temperature and long processing time, and continuous-wave (CW) random lase... |
41544128 | Dynamics of Solvating Water As a Probe of Polymers and Supramolecular Structures. | The (bio)chemical reaction dynamics of polymers and supramolecular systems are intimately related to the conformational dynamics of these systems. A relatively new approach to studying the structure and structural dynamics of large (bio)molecular systems in aqueous solution is the measurement of the dynamics of the sol... |
41544099 | Integrative pan-resistome and transcriptomic characterization reveals differential gene expression signatures in carbapenem-resistant Acinetobacter baumannii: Insights into efflux pump regulation and therapeutic targeting strategies. | Acinetobacter baumannii is a significant, multidrug-resistant pathogen that is increasingly recognized as an agent associated with hospital infections. Its increasing resistance to carbapenems and other necessary antibiotics poses a serious threat to public health worldwide. The present study provides an integrative an... |
41544078 | Impact of storage conditions on the stability and biological efficacy of trans-arachidin-1 and trans-arachidin-3. | Prenylated stilbenoids, particularly trans-arachidin-1 (Ara-1) and trans-arachidin-3 (Ara-3), have gained attention for their notable bioactivities and potential health-promoting properties. This study presents the first comprehensive investigation into the stability and biological efficacy of these compounds in both p... |
41543900 | An activator of a two-component system controls cell separation and intrinsic drug resistance in <i><i>Mycobacterium tuberculosis</i></i>. | Unlike commonly studied rod-shaped bacteria, mycobacteria grow from their poles, requiring precise coordination between division and initiation of new pole growth. The mechanisms that mediate this transition are largely unknown, but likely represent a rich source of drug targets for the treatment of mycobacterial infec... |
41543870 | How Crystal Size and Number Steer Asymmetric Crystallization. | Chiral amplification processes during crystallization can hinge on subtle asymmetries in crystal populations, yet the underlying kinetic drivers remain elusive. Here we experimentally investigate how size and mass imbalances between two enantiomeric crystal populations translate to asymmetric growth rates that determin... |
41543774 | Transcriptome and DNA methylation responses in the liver of Megalobrama amblycephala under hypoxia and heat stress. | Global warming and aquaculture expansion are raising water temperatures and decreasing dissolved oxygen (DO) in freshwater environments, threatening fish survival. Revealing the molecular mechanisms of fish response to heat and/or hypoxia is vital for the development of sustainable aquaculture and genetic breeding stra... |
41543484 | Rapid, High-Capacity, and Reusable Bovine Serum Albumin-Based Adsorbents for Perfluoroalkyl and Polyfluoroalkyl Substance Removal. | Albumin, a major carrier of perfluoroalkyl and polyfluoroalkyl substances (PFAS) in humans and animals, has been rarely explored for PFAS removal. In this study, bovine serum albumin (BSA) is transformed into an efficient, low-cost, and reusable adsorbent for PFAS removal. BSA is modified with amine-rich poly(ethylenim... |
41543324 | Crown@ZIF-67/MXene Sensor for Ultrasensitive and Selective On-Site Tl<sup>+</sup> Monitoring. | Thallium (Tl) is a highly toxic priority pollutant, yet reliable monitoring remains challenging because many Tl sensors lack sufficient selectivity, portability, and durability in complex waters. A tightly coupled Crown@ZIF-67/MXene composite was assembled and integrated onto a screen-printed carbon electrode (SPCE) to... |
41543266 | Vitamin B12 promotes cefiderocol resistance and small-colony variants in carbapenem-resistant <i>Acinetobacter baumannii</i>. | Carbapenem-resistant <i>Acinetobacter baumannii</i> (CRAB) is a global health threat with few effective treatment options remaining. Cefiderocol, a last-resort siderophore-cephalosporin antibiotic, exploits bacterial iron transport systems via TonB-dependent receptors (TBDRs) to gain cellular entry. However, treatment ... |
41543260 | Warfare among rice sheath pathogens: <i>Rhizoctonia solani</i> AG 1-IA neutralizes <i>Pseudomonas fuscovaginae</i> cyclic lipopeptides. | In this work, we investigated the chemical process underlying the interplay between two rice sheath pathogens: <i>Pseudomonas fuscovaginae</i>, the causal agent of sheath brown rot, and <i>Rhizoctonia solani</i> AG 1-IA, which causes sheath blight. Specifically, we studied the fate of the bacterial cyclic lipopeptides ... |
41543257 | Construction of Versatile Cascade Detection Platforms for Biomolecules Based on a Fluorescent Yttrium Metal-Organic Framework. | Fluorescent metal-organic frameworks (MOFs) are recognized as powerful materials in chemical sensing due to their tunable structures and outstanding optical properties. However, the simplistic one-step detection mode of conventional fluorescent MOF probes severely restricts the analyte diversity, while their advancemen... |
41543229 | Molecular Gardening for Neuroinflammation via Nose-to-Brain Delivery: A Ca<sup>2+</sup> Responsive DNA Nanocage-Hydrogel System With Neuron Targeting and STING Inhibiting. | Intranasal administration offers a rapid and non-invasive route to deliver therapeutics directly from the nasal cavity into the brain for treating central nervous system (CNS) disorders. However, its efficacy is hampered by limited CNS targeting efficiency and rapid clearance in the nasal microenvironment. Here, a Ca<s... |
41543198 | Synergistic Co-Doping of Barium and Cobalt Enables Stable and Active RuO<sub>2</sub> for Acidic Water Oxidation. | Developing acid-stable and active non-iridium oxygen evolution reaction (OER) electrocatalysts is crucial to facilitating the cost-effective and large-scale applications of proton exchange membrane water electrolysis (PEMWE) for hydrogen production. However, the instability of Ru sites and lattice oxygen loss limit the... |
41543175 | Induced-Fit Recognition by a Calixarene-Pyrene Conjugate for Single- and Dual-Wavelength Fluorescence Sensing in Water. | The discovery of fluorescence receptors that selectively bind small molecules with high affinity in aqueous media is critical for the development of new sensing and bioimaging assays. We herein report a new fluorescence receptor-dye chemosensor based on the monofunctionalization of p-sulfonatocalix[4]arene (SC4) recept... |
41543165 | <p>Immunotherapy after EGFR‑TKI treatment in advanced non‑small cell lung cancer: Current status and future perspectives (Review)</p>. | <p>The tumor microenvironment (TME) of epidermal growth factor receptor (EGFR)‑mutant non‑small cell lung cancer (NSCLC) exhibits notable immunosuppressive properties. EGFR tyrosine kinase inhibitors (EGFR‑TKIs) induce dynamic remodeling of the TME. By boosting the infiltration of immune cells such as T cells and dendr... |
41543074 | Evaluation of bioactive compounds in <i>Lysimachia arvensis</i> extract through in vitro cytotoxicity, density functional theory, non-covalent interaction analyses, and molecular dynamics simulations. | <i>Lysimachia arvensis</i> (L.) U. Manns & Anderb. is a medicinal plant traditionally used for various therapeutic purposes; however, its bioactive properties and potential toxicological effects remain insufficiently characterized. This study aimed to investigate the biological activity, cytotoxic potential, phytochemi... |
41542860 | Biochemical Interface Engineering for Transistor-Based Point-of-Care Diagnostics. | ConspectusPoint-of-care (POC) testing holds great promise for transforming clinical diagnostics by enabling rapid, convenient, and accurate analysis outside of centralized laboratories. Among various emerging technologies, biological field-effect transistors (bio-FETs), which directly convert molecular binding events i... |
41542770 | Targeting the N-acetyltransferase 10/DKK2 axis enhances CD8+ T cell antitumor activity in colorectal cancer models. | Despite overexpression of N-acetyltransferase 10 (NAT10) in colorectal cancer (CRC), its immunomodulatory role in the tumor microenvironment remains elusive. Here, we reveal that NAT10 promotes immune evasion through N4-acetylcytosine-dependent (ac4C-dependent) mRNA stabilization. Using syngeneic mouse models (MC38/CT-... |
41542752 | Targeted computational design of an interleukin-7 superkine with enhanced folding efficiency and immunotherapeutic efficacy. | Interleukin-7 (IL-7) plays a central role in maintaining T cell development and immune homeostasis, and enhancing the cytokine's immune-stimulatory functionality has broad therapeutic implications against various oncological malignancies. Herein, we show a computationally designed IL7 superkine, Neo-7, which exhibits e... |
41540912 | Natural Cell-Inspired Integration of Redox Reactant Molecules in Hierarchical MOFs Harvested for Reaction Pathway-Regulated Glycoprotein Assay. | Natural cell systems with multiple isolated compartments possess controllable signal transduction pathways, which can segregate a series of complex substances and confine them from each other to allow for feedback-driven reactions. By biomimicking the ingenuity of cell systems, we herein designed spatially compact meta... |
41540908 | Amplified Recognition of Basic Anions Induced by Cooperative Interaction of Ureido-Binding Sites Preorganized by Azacalix[4]arene Skeleton. | The reaction of tetranitropolyamino carriers with 4-<i>tert</i>-butylphenyl isocyanate gives rise to ureido-based receptors. These receptors vary in the acidity of their bridging N<i>H</i> groups on supporting skeletons, significantly affecting their complexation ability. While introducing nonbasic anions leads to the ... |
41540713 | Sources and Metabolism of D-Amino Acids and Their Roles as Biomarkers in Kidney Disease: A Review. | The human body acquires D-amino acids from multiple sources, with intestinal microbiota being the most significant contributor, followed by dietary intake and limited synthesis within the nervous system. Microbiota-derived D-amino acids can either be excreted directly in feces or absorbed into the systemic circulation,... |
41540399 | A highly photothermal stability Au@Cu<sub>2 - x</sub>Se nanoprobe for photoacoustic-imaging guided dual enhanced NIR- II photothermal/chemodynamic therapy. | The deep-seated locations and hypoxic microenvironments of tumors critically hinder conventional phototherapies. To overcome these limitations, we engineered a novel Au@Cu<sub>2 - x</sub>Se nanoprobe via precise aspect ratio control of gold nanorods for NIR-II plasmonic resonance and site-specific growth of Cu<sub>2 - ... |
41540302 | Therapeutic potential of diosgenin in hepatocellular carcinoma through molecular mechanisms and nanodelivery strategies. | <h4>Purpose</h4>The review aims to comprehensively examine the anticancer potential of diosgenin, a natural steroidal sapogenin, in the context of hepatocellular carcinoma (HCC). It highlights the underlying mechanisms of action, discusses diosgenin's limitations in bioavailability, and evaluates nanotechnology-based d... |
41540003 | The aryl hydrocarbon receptor: structure, signaling, physiology and pathology. | The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor of the bHLH/PAS protein family. In this review, we explore the multifaceted roles of AHR in both health and disease, tracing its recognition as a xenobiotic sensor and a central regulator of physiological homeostasis. We begin by recounting ... |
41540015 | Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibits progression of oral squamous cell carcinoma through ABCA1-regulated cholesterol efflux. | Splice quantitative trait loci (sQTL) serve as another critical link between genetic variations and human diseases, besides expression quantitative trait loci (eQTL). Their role in oral squamous cell carcinoma (OSCC) development remains unexplored. We collected surgically resected cancer and adjacent normal epithelial ... |
41339092 | PANTHER Score: Protein-Affinity for Nucleic Target-binding, Hybridization, and Energy Regression. | Although protein-RNA interactions are crucial for many biological processes, predicting their binding free energies (Δ<i>G</i>) is a challenging task due to limited available experimental data and the complexity of these interactions. To address this issue, we developed a machine learning-based model designed to predic... |
41285614 | Loop of fate: structural and mechanistic insights into hnRNPA1 binding to the hepatitis C virus RNA. | Hepatitis C virus (HCV) is a major global health burden, associated with chronic liver diseases, including cirrhosis and hepatocellular carcinoma. Viral replication critically depends on conserved <i>cis</i>-acting replication elements (CREs), such as the 5BSL3.2 stem-loop near the 3' end of the open reading frame. Thi... |
41869413 | Lipid-Engineered Small-Sized Metal-Organic Frameworks for Targeted Delivery of Anlotinib in Lung Cancer Treatment. | <h4>Purpose</h4>In this study, we report the design and evaluation of Anlo@MOF-Lipo (AML), a liposome coated, small sized MIL-101(Fe) metal-organic framework (MOF) for targeted delivery of the multi target tyrosine kinase inhibitor anlotinib in lung cancer treatment.<h4>Methods</h4>In detail, the biomimetic liposome sh... |
41869410 | Targeted Delivery of Nucleic Acid Therapeutics: Emerging Carriers and Applications in Common Metabolic and Inflammatory Diseases. | Recent advances in genomics and molecular biology have accelerated the development of nucleic acid-based therapeutics. To optimize their clinical efficacy, various delivery systems-including lipid nanoparticles, polymeric nanomaterials, inorganic nanoparticles (NPs), extracellular vesicles (EVs), viral vectors, protein... |
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