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41538362 | EGFR activation disrupts immunotherapy response via SHP2-mediated suppression of tumor-intrinsic response to IFN-γ. | Epidermal growth factor receptor-activating (EGFR-activating) mutations are established biomarkers of resistance to immune checkpoint blockade (ICB) in lung cancer, yet the precise molecular mechanism and effective therapeutic strategies remain elusive. In this study, we show that EGFR overexpression and amplification ... |
41538321 | Ion Diffusion and (Photo)redox Conductivity in a Covalent Organic Framework. | Covalent organic frameworks (COFs) have emerged as promising materials for energy-related applications, where precise control over charge and mass transport is critical, such as in electrocatalysis and battery technologies. Despite ongoing debates on the mechanisms of charge transport in COFs─particularly band transpor... |
41537741 | Epithelial-dermal inflammasome crosstalk in cutaneous squamous cell carcinoma. | Epithelia maintain their barrier function through the proliferative and plastic behavior of stem cells that drive continuous tissue regeneration. However, these same properties render epithelia susceptible to tumorigenesis. The skin, the largest epithelial barrier, is the source of the most prevalent human cancers, yet... |
41537637 | A Perspective on Ultrafast Excited-State Dynamics: From Molecular Aggregates to Conjugated Polymer Nanoparticles. | ConspectusAqueous organic assemblies, including molecular aggregates (MAs), conjugated polymer nanoparticles (PNPs), and their hybrids, have emerged as versatile soft materials for solar light harvesting, photocatalysis, and bioimaging. Such assemblies form through spontaneous self-organization processes, including hyd... |
41537590 | A modeling-based framework to evaluate forgiveness of tuberculosis treatment in a BALB/c relapsing mouse model. | Tuberculosis (TB) remains a leading cause of death due to an infectious agent. Adherence to long and complex TB treatments is supported by methods including directly observed therapy. The negative impact of missed drug doses on clinical outcomes is well established, highlighting both the importance of adherence support... |
41537579 | Silver nanoparticle-antimicrobial peptide supramolecular nanocomposite coating improves implant osseointegration under mechanical loading. | <h4>Background</h4>Long-term implant success depends on preventing infection and achieving initial stability, yet many antimicrobial coatings impair osseointegration, and most animal models overlook the impact of mechanical loading. To overcome the limitations of static <i>in vivo</i> models that do not reflect the mec... |
41537559 | Defect-Engineered MOF/COF S-Scheme Heterojunction With Dual-Channel Charge Transport for Ultraefficient Solar-Powered Heavy Metal Remediation. | Rapid recombination of photogenerated carriers severely limits the photocatalytic performance of conventional semiconductor photocatalysts, while conventional heterojunctions generally suffer from inefficient charge separation and sluggish interfacial kinetics due to poor lattice matching and unidirectional recombinati... |
41537527 | Site- and Size-Controlled PEGylation Modulates Biointerfaces and Immunoregulatory Functions of Bifunctional Peptides in an Autoimmune Disease Model. | Autoimmune diseases arise from dysregulated autoreactive T cell activation, and current therapies rely on broad immunosuppression that predisposes patients to infection and malignancy. Antigen-specific strategies such as bifunctional peptide inhibitors (BPIs), which couple an antigenic epitope with an ICAM-1-binding se... |
41537489 | Self-Induced Buckling in Hollow Microgels. | Hollow microgels are elastic polymer shells easily realizable in experiments. Recent works have shown the emergence of buckling events in dilute hollow microgels under the effect of an added osmotic pressure. Here, we perform large-scale simulations to show that these microgels at high enough packing fractions undergo ... |
41537395 | Enhanced Epigenetic Modulation via mRNA-Encapsulated Lipid Nanoparticles Enables Targeted Anti-inflammatory Control. | Temporal transcriptional modulation of immune-related genes offers powerful therapeutic potential for treating inflammatory diseases. Here we introduce an enhanced zinc finger (ZF)-based transcriptional repressor delivered via lipid nanoparticles for controlling immune signaling pathways <i>in vivo</i>. By targeting My... |
41535643 | The mRNA-Based Innovative Strategy: Progress and Challenges. | As the central template for protein expression, messenger ribonucleic acid (mRNA) holds immense potential for novel therapeutic strategies. Over the past few decades, mRNA-based therapeutics have demonstrated remarkable efficacy in a range of applications, including epidemic vaccine, cancer vaccine, protein replacement... |
41535540 | Key Advancements and Emerging Trends of Perovskite Solar Cells in 2024-2025. | The past two years have witnessed remarkable progress in perovskite solar cells (PSCs), marked by breakthroughs in power conversion efficiency and strides in addressing long-term operational stability. At present, the certified power conversion efficiencies of single-junction PSCs and silicon/perovskite tandem cells ha... |
41535523 | Mechano-Electrochemical Synergy in Cellulose@MOF Scaffold-Based Asymmetric Electrolyte for Stable Solid-State Lithium Metal Batteries. | The application of polymer electrolytes is expected to revitalize solid-state lithium metal batteries (SSLMBs) with high energy density and enhanced safety. However, practical deployment faces challenges from inadequate mechanical properties of electrolyte and unstable interfaces in high-voltage SSLMBs. Herein, we desi... |
41536253 | Thianthrene Position Isomerism in Polycyclic Aromatic Hydrocarbons toward Efficient and Long-Lived Room-Temperature Phosphorescence. | Purely organic room-temperature phosphorescence (RTP) materials have garnered significant attention. However, balancing the phosphorescence quantum yield (Φ<sub>P</sub>) and phosphorescence lifetime (τ<sub>P</sub>) remains a fundamental challenge in developing high-performance organic RTP materials. Herein, we utilize ... |
41536235 | Precision-Engineered Silver Single-Atom Carbon Dot Nanozymes for Theranostic Management of Acute Kidney Injury. | Overproduction of reactive oxygen species (ROS) is a key pathogenic feature in acute kidney injury (AKI), leading to rapid decline in renal function with high mortality rates that call for effective antioxidant therapies. Herein, we present triphenylphosphonium-functionalized carbon dots supported by single-atom silver... |
41536226 | Next-generation composite vesicular systems: an in-depth review of proniosomes in advanced drug delivery. | Proniosomes represent an advanced composite vesicular platform that integrates non-ionic surfactants, lipids, and biodegradable carriers to significantly improve drug solubility, stability, and transmembrane delivery. These dry powdery formulations are transformed into multiscale niosomes upon contact with a hydrated m... |
41536197 | Enantioselective Hydrolactonization Catalyzed by Chiral Borophosphates. | The direct asymmetric hydrolactonization of olefinic carboxylic acids without the aid of electrophilic initiators remains a significant challenge in synthetic chemistry. Herein, we report an enantioselective, metal-free hydrolactonization of olefinic carboxylic acids utilizing an <i>in situ</i>-generated chiral boropho... |
41535973 | Deep eutectic solvents for green extraction and separation of bioactive compounds from traditional Chinese medicines. | <h4>Background</h4>Traditional Chinese Medicines (TCM) has long relied on bioactive compounds derived from natural sources, but conventional extraction and separation methods often involve violate/hazardous organic solvents, posing environmental and health risks. Deep Eutectic Solvents (DESs) have emerged as a sustaina... |
41400256 | Metal-metalloporphyrin MOF-derived core-shell Ni<sub>3</sub>Fe@FeNi-NC towards high-performance bifunctional oxygen electrocatalysis. | A core-shell Ni<sub>3</sub>Fe@FeNi-NC composite catalyst, characterized by robust interactions, was prepared by the direct pyrolysis of a 2D metal-metalloporphyrin framework. The graphitized carbon coating enhanced electron transfer and stability, resulting in superior bifunctional catalytic activity in the ORR/OER and... |
41400158 | Advanced functional MOFs for CO<sub>2</sub> capture and separation. | The efficient capture and separation of carbon dioxide (CO<sub>2</sub>) represents a pivotal strategy for mitigating climate change and achieving a sustainable carbon economy. Metal-organic frameworks (MOFs) have emerged as highly promising adsorbents for CO<sub>2</sub> separation processes, owing to their exceptional ... |
41400136 | Luminescent metal-organic framework (MOF) sensors for sensitive determination of nicotine in breast milk. | Breastfeeding is essential for the healthy development and growth of infants, fostering a strong bond between mother and child. Exposure to nicotine through maternal smoking represents a significant risk to the health of both. This study proposes the quantification and monitoring of nicotine by molecular fluorescence i... |
41399896 | One-pot <i>in situ</i> Co-assembly of binary ZIF-8/MoS<sub>2</sub>, ZIF-8/V<sub>2</sub>O<sub>5</sub>, and ternary ZIF-8/MoS<sub>2</sub>/V<sub>2</sub>O<sub>5</sub> composite supercapacitor electrodes. | High-performance electrodes for next-generation supercapacitors require hierarchical porosity and coupled EDLC/pseudocapacitance. In this work, we have synthesized three ZIF-8-based composites: ZIF-8/MoS<sub>2</sub>, ZIF-8/V<sub>2</sub>O<sub>5</sub>, and ZIF-8/MoS<sub>2</sub>/V<sub>2</sub>O<sub>5</sub>, by a scalable o... |
41399872 | Tracking single-molecule ferritin reassembly and disassembly using polymer-coated nanopores. | Ferritin is a multimeric protein that stores and releases iron, emerging as a promising candidate for nanomedicine, particularly in targeted drug delivery. Its ability to disassemble and reassemble under specific environments is crucial for encapsulating and releasing therapeutic payloads. In this work, we monitor ferr... |
41370841 | 3D covalent organic framework with crown ether and POSS motifs for selective recovery of Au(III) and Pd(II) from highly acidic wastewater. | The recovery of Au(III) and Pd(II) from wastewater is crucial for both metal recycling and environmental protection. Three-dimensional covalent organic frameworks (3D COFs) have emerged as promising materials for the selective adsorption and recovery of metal ions from dilute solutions. Herein, we overcame the challeng... |
41370087 | Optical control of carrier-mediated ion transport by photoswitchable lipids. | We report a molecular strategy for precise, reversible, and noninvasive photoregulation of ion-selective membrane transport. Embedding azobenzene-containing photolipids into bilayers enables nanoscale control over the interaction and mobility of small-molecule ion carriers. Photoisomerization alone produces only minor ... |
41370041 | Molecular insight into the efficient & robust design of vesiculated protein nano-cages. | Recently, recapitulation of viromimetic function in non-viral protein nanocages (PNCs) has emerged as a strategy to successfully encapsulate them in membrane vesicles. This method successfully evaded immune system detection. The mechanism responsible for triggering membrane budding and vesiculation remains elusive. Thi... |
41369585 | Fluorinated Zr-MOF-modified separators for Li-S batteries with enhanced electrochemical performance. | Considering the asymmetric development of the demand for new energy, two Zr-based MOF materials were successfully synthesized using a solvothermal method. Using ZrCl<sub>4</sub> as the metal source, UiO-66-4F and UiO-66 were prepared with 2,3,5,6-tetrafluoroterephthalic acid (H<sub>2</sub>BDC-4F) and terephthalic acid ... |
41363174 | Enhancing water release in atmospheric water harvesting systems by mixing oligomeric liquids with metal-organic framework. | Global water access issues and growing energy demands necessitate advanced water-extraction technologies such as atmospheric water harvesting (AWH). However, conventional AWH systems often require intensive energy input for water desorption, which limits their practical application. This study focuses on reducing the d... |
41351575 | Bridged chemistry of macrocyclic arenes: from sp<sup>3</sup>-carbon bridges to π-conjugation and heteroatom bridging. | Macrocyclic arenes are a class of host molecules featuring precisely adjustable cavities and abundant recognition sites, which facilitate rich host-guest interactions. Their bridging structures-such as methylene groups, conjugated units, and heteroatoms (<i>e.g.</i>, O, S, N, and Si)-can be rationally designed to fine-... |
41347532 | Recent advances in developing bioactive porous organic cages for fluorescence bioimaging, drug delivery, and therapies. | Porous organic cages (POCs) are a class of covalently-linked three-dimensional materials with precise molecular structures, well-defined intrinsic cavities, and versatile tunabilities. Many POCs were primarily linked through dynamic reversible imine bonds, which resulted in limited stability under aqueous and harsh con... |
41220305 | Enhanced CO<sub>2</sub> affinity in a metal-organic framework through green incorporation of a dual-functional amino acid. | Post-synthetic incorporation of amino acids into the Zr-based metal-organic framework DUT-67 <i>via</i> relatively green methods yields materials with enhanced CO<sub>2</sub> affinity. Structural and sorption studies reveal high affinity for DUT-67-Trp, exploiting its dual functionality to achieve an adsorption enthalp... |
41973153 | Surface-Modified Superparamagnetic Iron Oxide Nanoparticles (SPIONs) in a New Perspective for Prostate Cancer Therapy. | <h4>Purpose</h4>Prostate cancer circulating tumor cells (PCTCs) are often found in the blood of patients suffering from metastatic prostate cancer and they are responsible for contributing to metastatic progression. Superparamagnetic Iron Oxide Nanoparticles (SPIONs) have been widely studied in the context of biomedica... |
41869409 | Recent Advances in Nanoscale Sprayable Hydrogels for Cancer Management: Nanoparticle-Loaded Formulations for Therapy and Prevention. | Sprayable hydrogels represent an emerging class of nanoscale, localized drug delivery systems in oncology, offering rapid in situ gelation, strong tissue adhesion, and minimally invasive administration. Recent advances have integrated nanotechnology into sprayable hydrogel formulations to enhance therapeutic efficacy a... |
41858588 | Nanomedicines Reshape the Tumor Microenvironment: Multidimensional Strategies from Modulating "Barriers" to Metabolic Intervention. | Nanoparticle-driven remodeling of the Tumor Microenvironment (TME) represents a transformative strategy in cancer therapy, shifting from traditional approaches to multidimensional modulation. This review explores how engineered nanoparticles precisely target and alter key TME components-including immune cells (eg, NK c... |
41858580 | Nanomedicine-Enabled/Augmented Cell Autophagy to Mitigate and Boycott the Development and Progression of Atherosclerotic Plaque. | Atherosclerosis (AS) is a chronic, inflammatory and systemic disease that seriously threatens human health and is the main factor leading to the morbidity and mortality of cardiovascular diseases. Autophagy has been regarded as an effective therapeutic strategy for AS, which can represent an important self-protecting i... |
41853234 | Insights into drug resistance in <i>Leishmania</i>: Mechanisms, therapeutics, and clinical case studies. | <h4>Background and purpose</h4>Leishmaniasis, a neglected tropical disease caused by the protozoan parasite <i>Leishmania</i>, remains a significant public health concern in endemic regions. The disease manifests in various forms, including cutaneous, mucocutaneous, and visceral leishmaniasis, each associated with spec... |
41837226 | Challenges and Opportunities in Core-Shell Zeolite Catalysts. | Zeolites with core-shell morphologies represent a captivating class of materials that exhibit distinctive catalytic properties in comparison with conventional zeolite catalysts. Due to the ordered organization of each zeolite component in a core-shell configuration, the stability, mass transport characteristics, and pr... |
41816303 | Carbonaceous supports for Schiff base metal complexes: Strategies for enhanced catalytic efficiency. | Recent developments in anchoring metal-Schiff base complexes onto carbonaceous polymeric matrices highlight the growing emphasis on using carbonaceous polymers as versatile support materials. The development of supported metal catalysts has gained significant attention due to their potential to combine the advantages o... |
41810471 | Advances in nano-delivery systems for overcoming the challenges of applying siRNA drugs in tumor therapy. | Tumors pose a serious threat to human life and health. In recent years, gene therapy against tumors has garnered considerable attention. Small interfering RNAs (siRNAs), an important class of nucleic acid drugs, can silence the mRNAs of tumor-associated genes with high specificity through RNA interference (RNAi), inhib... |
41777304 | Micellization of Organic Conjugated Polymers toward Functional Nanomaterials for Photocatalytic Applications. | Organic conjugated polymers (CPs) with an extended π-conjugated backbone exhibiting unique photophysical and chemical properties (e.g., good chemical stability, tunable light absorption, superior charge mobility, etc.) have been developed as promising photosensitizers for wide photocatalytic applications. Most of the r... |
41726332 | OBIMAP (One-Bead Interchain Multipeptide Assembly Platform). | A significant advancement in Merrifield's classic solid-phase peptide synthesis (SPPS) that greatly expands the scope of accessible peptide structures is reported here. Building upon the one-bead, one-compound (OBOC) concept, this approach enables the simultaneous synthesis of multiple peptides on a single bead, follow... |
41705032 | Materials design for thermally improved safety in lithium-ion batteries. | With the ever-increasing demand for high-energy-density lithium-ion batteries (LIBs) in multiscale energy storage, safety concerns have emerged as critical obstacles hindering their widespread application. The excess heat generated during the electrochemical process, if not properly managed, can accumulate and accelera... |
41703824 | Hydroxypropyl-β-cyclodextrin as a co-delivery vehicle for synergistically enhancing fucoxanthin oral bioavailability through dual regulation of SR-B1 and ABCB1 transporters. | Hydroxypropyl-β-cyclodextrin (HPβCD) serves as an effective carrier for enhancing the delivery of poorly soluble actives. In this work, an HPβCD-based delivery system encapsulating the marine carotenoid fucoxanthin (FUCO) and the transporter-regulating isoquercitrin (IQ) was prepared via high-pressure homogenization (H... |
41695479 | <i>Panax notoginseng</i>-Derived Carbon Dots Herbzymes Ameliorate Renal Ischemia-Reperfusion Injury via Anti-Inflammation, Antioxidation and Gut-Kidney Axis Regulation. | Renal ischemia-reperfusion injury (RIRI) mainly comes from inflammation and oxidative stress. Treating with inflammation monotherapy or oxidative stress monotherapy can't reduce RIRI. This study involved the synthesis of <i>Panax notoginseng</i>-derived carbon dots (PN-CDs) herbzymes, nanozymes from Chinese herbal medi... |
41695470 | A ribonucleotide carbohydrate system (iRNC) enhances antigen presentation and controls glioblastoma. | <b>Rationale:</b> Messenger RNA (mRNA)-based cancer vaccines hold great potential as immunotherapeutic agents; however, their clinical translation remains hindered by inefficient systemic delivery, suboptimal antigen presentation, and formulation-associated toxicity of lipid nanoparticles (LNPs). To address these issue... |
41693849 | Design and Performance of a Novel Scalable Core-Sheath Inverted Nozzle Soft Material Pressure Spinner. | Core-sheathed inverted nozzle pressurized gyration (CsINPG) is a novel fiber manufacturing process based on gas blowing-assisted rotary coaxial spinning technology, capable of large-scale manufacture of core-sheathed, micropolymeric structures. The CsINPG spinning vessel is constructed from polycarbonate and has a uniq... |
41676226 | Oxygen-Vacancy-Engineered Pd-WO<sub>3-<i>x</i></sub> for Enhanced Plasma-Catalyzed CO<sub>2</sub> Hydrogenation to CO. | Plasma-catalytic CO<sub>2</sub> hydrogenation to CO offers a promising route for carbon-neutral chemical synthesis. However, its advancement is constrained by low energy efficiency and limited mechanistic insight. Here, we developed an oxygen vacancy-engineered Pd-WO<sub>3-<i>x</i></sub> catalyst supported on nickel fo... |
41647170 | Current use of pre-clinical models for evaluation of human adenovirus-based cancer therapeutics. | Human adenoviruses (HAdVs) are enjoying a renaissance in interest for the development of cancer therapies following the approval of Adstiladrin (Ferring Pharmaceuticals) for the treatment of bladder cancer, strong phase 3 data from CG Oncology's cretostimogene grenadenorepvec, and many other products in late-stage clin... |
41641077 | Inhibition of FGFR signaling with infigratinib improves linear bone growth in the female <i>Aga2/+</i> mouse model of osteogenesis imperfecta. | Osteogenesis imperfecta, a genetically heterogeneous disorder, is characterized by brittle bones with recurrent fractures as well as short stature. A recent study investigating cellular signaling in growth plate chondrocytes identified an increased expression of FGF receptors and elevated FGF signaling. We inhibited FG... |
41637787 | Integrative metabolome and transcriptome analyses provide insights into skeletal muscle development of two duck breeds during embryonic stage. | Yulin black duck with an all black body, is a native duck breed from Guangxi Province, China, and people like to use the duck to make soup because its meat is considered as a nutritious food and medicinal herb. At present, the molecular mechanisms related to its meat characteristics are still unclear. Furthermore, the ... |
41629046 | Lipase-based HKUST-1 (Cu) biocomposites as chiral stationary phase for enantiomer separation in capillary electrochromatography. | <h4>Background</h4>Enantiomers may have differences in biological effects, pharmacological activity, and toxicity. Currently, global regulatory authorities are imposing increasingly stringent approval requirements for single-enantiomer drugs. Coupled with the continued growth of the chiral pharmaceutical market, this m... |
41626492 | The Role of Spacer Segments in Increasing the Transfection Efficacy of Au-Core Polymeric-Shell Nanoparticulate Gene Vectors. | The surface chemistry of gold nanoparticles is a key determinant of their final biological properties. In this study, we investigated the influence of the PEG chain length, positioned between the gold core and the cationic polymer, on the transfection efficiency in HeLa and HGF cell lines. Two types of nonviral vectors... |
41626489 | Design of Nanomaterial-Based Sensors for Enhanced Halogen Bonding. | Halogen bonding is a highly directional, noncovalent, intermolecular interaction which has been harnessed for a variety of applications, including sensor design. A halogen bond (XB) is formed between a region of positive electrostatic potential on a halogen atom (X) and electron rich portions of target molecules. The s... |
41626465 | Impact of Single Halogen Atom Substitutions on Antiviral Profile of Inhibitors Targeting SARS-CoV‑2 Main Protease. | The SARS-CoV-2 main protease (M<sup>pro</sup>) remains a prime antiviral target because its inhibition halts viral replication. To probe how subtle atomic changes influence drug performance, we carried out a systematic halogen scan on a potent ketoamide scaffold, replacing a single fluorine with chlorine, bromine, or i... |
41626440 | Sensing of Nitroaromatics Using Substituted Nitrene-Functionalized Boron Carbide Nanosurfaces. | The search for new functional nanomaterials with tunable properties is an ongoing research field. This study presents a density functional theory of the functionalization of boron carbide (BC<sub>3</sub>) nanosurfaces with nitrene intermediates, resulting in new nanosurfaces with 7-membered rings that can be used for t... |
41608643 | Light as a Weapon: Redefining Cancer Care with Photodynamic Therapy. | Photodynamic therapy (PDT) has evolved over the past decade into a versatile cancer treatment modality, fueled by advances in photosensitizer design, nanotechnology, and immunotherapy. Smarter photosensitizers, ranging from activatable and oxygen-independent scaffolds to red/NIR-absorbing chromophores, have expanded tu... |
41608617 | The Interaction of <i>CircESR1</i> and HNRNPAB Regulates Cell Cycle Transition of Breast Cancer Cell. | The mechanisms by which circRNAs regulate estrogen receptor (ER)-positive breast progression and therapeutic resistance remain poorly defined. By screening circRNAs involved in ER signaling, <i>circESR1</i> was identified as a novel circRNA exhibiting high specificity of expression in ER+ breast cancer. <i>CircESR1</i>... |
41608578 | Contemporary opportunities and potential of Auger electron-emitting theranostics. | Recent breakthroughs in radiopharmaceutical (RP) therapy have emerged interest in employing Auger electron (AE)-emitting radionuclides as potential agents for precise theranostics. AE provides energy with exceptional localization due to their short tissue penetration range (TPR, < 10 nm), rendering them particularly ef... |
41608577 | Engineering polysaccharide nanoplatforms for glioblastoma theranostics: Bridging targeted therapy and advanced imaging. | Glioblastoma (GBM) is an aggressive brain tumor characterized by limited therapeutic efficacy and challenges in accurate imaging, largely due to its invasive growth, drug resistance, and the restrictive blood-brain barrier (BBB) hindering the delivery of both therapeutic and diagnostic agents. Current GBM treatments an... |
41614172 | Deep-Sea Genome Mining Reveals Cooperative ATP-Grasp Ligase-Directed Biosynthesis of Pentacyclic Myxomiditides with Potent Protease Inhibition. | Microviridins are ribosomally synthesized and post-translationally modified peptides, typically featuring a conserved tricyclic structure formed by two ATP-grasp ligases. However, the diversity and evolution of these enzymes remain incompletely understood. Here, we identify a distinct ATP-grasp ligase subclade (MyxF) t... |
41614141 | Structural basis for the allosteric regulation and catalytic mechanism of <i>Staphylococcus aureus</i> UMP kinase. | <i>Staphylococcus aureus</i> uridine monophosphate kinase (saUMPK) functions as a hexameric enzyme that catalyzes the reversible reaction: Mg<sup>2+</sup> ⋅ ATP + UMP ↔ Mg<sup>2+</sup> ⋅ ADP + UDP. As a key enzyme in pyrimidine metabolism with no detectable homologs in eukaryotes, saUMPK represents an attractive antiba... |
41614126 | Proteomics and acetyl-proteomics reveal the antibacterial mechanism of berberine sulfate against methicillin-resistant <i>Staphylococcus aureus</i>. | <h4>Introduction</h4>The rising prevalence of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) underscores an urgent need for novel antibacterial strategies. Although the natural antibacterial agent berberine sulfate exhibits inhibitory effects against MRSA, its precise molecular targets and mechanisms of acti... |
41614057 | An integrated subtractive genomics and immunoinformatic approach for designing a multi-epitope peptide vaccine against methicillin-resistant <i>Staphylococcus aureus</i>. | <h4>Introduction</h4>MRSA is a multi-drug-resistant bacteria responsible for severe infections that has become a major health concern. Due to constraints of traditional methods, there is a need for developing a new approach to prevent the MRSA-related infections by targeting key pathogens.<h4>Methods</h4>Initially, the... |
41614068 | Dual inhibition of ERG11 and CDR2 in drug-resistant <i>Candida albicans</i> by Indian phytochemicals: a combined <i>in silico-in vitro</i> approach. | Invasive candidiasis caused by drug-resistant <i>Candida albicans</i> is an escalating global health concern due to the declining efficacy of conventional antifungal therapies. In this study, Indian medicinal phytochemicals were investigated as potential dual inhibitors of the key resistance determinants ERG11 (lanoste... |
41613942 | Exploring the effect of skim milk on the membrane stability of frozen-thawed Inner Mongolia cashmere goat sperm based on proteomics. | <h4>Introduction</h4>The cryopreservation of semen from the Inner Mongolia cashmere goat, a valuable dual-purpose breed in China, results in a sharp decline in sperm motility, hindering genetic improvement and germplasm propagation. This study aimed to investigate the protective effects and underlying mechanisms of ski... |
41613597 | Current status and challenges of therapeutic targets, novel drugs and delivery systems for hepatitis B: how far to our goal? | Hepatitis B (HB) remains a global public health challenge, imposing significant burdens on patients and society. Therapeutic strategies and novel drug development for HB continue to be a major research focus, yet current treatments fail to achieve satisfactory clinical cure rates. To address this critical gap, more eff... |
41613119 | Enhancing anti-tumor immunity through co-blocking PD-L1 and TIGIT by facilitating tumor-directed responses and additional VEGF inhibition. | Combination therapy targeting the PD-1/PD-L1 and TIGIT pathways has been explored to enhance the efficacy of current immunotherapies. In this study, we investigated strategies to further potentiate the co-blockade of PD-L1 and TIGIT for cancer immunotherapy. Firstly, we demonstrated that the bispecific antibody (HB0036... |
41613079 | Predictive multi-omic biomarkers for urban zoonotic spillover detection: an integrative review. | Urban wildlife is an overlooked yet critical component of zoonotic disease surveillance, especially in biodiversity hotspots where human-animal interfaces accelerate spillover risk. This review synthesizes five complementary omics layers: Host microRNAs, host-pathogen genetic markers, bacterial microbiome profiling, vi... |
41611411 | Fe-doped ZnMOF-derived heterocarbon nanotubes for electrochemical sensing of carbendazim residues in food. | <h4>Background</h4>Carbendazim (CBZ), is a benzimidazole fungicide and widely used for controlling fruit and vegetable diseases, which poses significant risks to human health due to its neurotoxicity, endocrine disruption, and reproductive toxicity. Sensitive and rapid monitoring of carbendazim residues in food is esse... |
41599746 | Current Pharmacotherapeutic Strategies in Diffuse Gliomas: Focus on Glioblastoma, IDH-Wildtype, and Emerging Targeted Therapies for IDH-Mutant Tumors. | Glioblastoma, isocitrate dehydrogenase (<i>IDH1/2</i>) wild-type (IDH-wildtype), is one of the most aggressive and malignant tumors of the central nervous system, characterized by rapid growth, pronounced cellular heterogeneity, and an exceptionally poor prognosis. The median survival time for patients with glioblastom... |
41599745 | Terpenoids: Emerging Natural Modulators for Reversing ABC Transporter-Mediated Multidrug Resistance in Cancer Chemotherapy. | Multidrug resistance (MDR) is a central cause of chemotherapy failure and tumor recurrence and metastasis, and its mechanism involves enhanced drug efflux, target mutation, upregulation of DNA repair and remodeling of the tumor microenvironment. ABC transporter protein (P-gp, MRP, and BCRP)-mediated efflux of drugs is ... |
41599738 | Molecular Interaction and Biological Activity of Fatty Acids and Sterols: An <i>In Silico</i> and <i>In Vitro</i> Approach Against <i>Haemonchus contortus</i>. | <b>Background:</b><i>Haemonchus contortus</i> is a gastrointestinal nematode that affects small ruminants and exhibits widespread resistance to commercial anthelmintics. This has driven interest in natural compounds such as fatty acids and sterols; however, their biological relevance against resistant parasite strains ... |
41599517 | Hydrophobic Modification of Alginate Nanofibrous Membrane by Group IV Elements Ion Crosslinking. | Hydrophobic nanofiber membranes derived from the biopolymer alginate were fabricated by electrospinning followed by metal ion crosslinking, and their potential as oil-water separation membranes was primarily investigated. Sodium alginate (SA) was co-electrospun with polyethylene glycol and subsequently crosslinked usin... |
41599518 | Adhesive Gelatin-Based Eutectogels: A Review of Synthesis, Properties, and Applications. | This review presents a focused assessment of the rapidly expanding field of gelatin-based eutectogels and identifies the gaps in current literature that justify this examination. Research on deep eutectic solvents (DESs and NADES) has advanced quickly, yet there is still no integrated view of how these solvent systems ... |
41599514 | Ultrasonic-Formic Acid Pretreatment Coupled with Metal Ion/Deep Eutectic Synergistic Catalysis: Efficient Conversion of Biomass to 5-Hydroxymethylfurfural. | This study developed a two-step conversion strategy for the efficient conversion of bamboo waste into 5-hydroxymethylfurfural (HMF). First, ultrasonic-assisted formic acid pretreatment was used at 80 °C for 3 h, removing approximately 83.7% of hemicellulose and 76.5% of lignin from the biomass, with a cellulose recover... |
41599348 | Design and Application of Hetero-Multicomponent Metal Oxide Photocatalysts for Wastewater Treatment: Ti-Cu-Zn Catalysts and Future Research Directions. | Hetero-multicomponent metal oxide catalysts are attracting increasing attention for wastewater remediation due to their tunable band structures, synergistic redox activity, and enhanced stability. This review thoroughly evaluates recent progress in the synthesis and application of such catalysts, highlighting Ti-Cu-Zn ... |
41599340 | Mutagenic Potentials of DNA Interstrand Cross-Links Induced by 7,8-Dihydro-8-Oxoadenine. | DNA interstrand cross-links (ICLs) are among the most cytotoxic forms of DNA damage, arising when the two strands of the DNA helix are covalently linked by crosslink-inducing agents such as bifunctional alkylating agents and reactive aldehydes. Several studies have demonstrated that ICLs can also be induced by reactive... |
41599215 | From Classics to Nano-Excipients and Biopolymers: Pulmonary Drug Delivery Formulations. | In this article, a systematic review and analysis of the present literature is conducted, regarding the excipients present in dry powder inhaler formulations. Until now, there has been no list of excipients recorded, specifically for DPIs, with the number of approved excipients for pulmonary delivery being restricted, ... |
41598608 | Fracture Occurrence Within FRAX-Defined High-Risk Myasthenia Gravis: An Exploratory Stratification by Age and Activities of Daily Living. | <b>Background/Objectives</b>: Patients with myasthenia gravis (MG) are at increased risk of osteoporotic fractures due to long-term oral corticosteroid use and disease-related muscle weakness. FRAX<sup>®</sup> estimates 10-year fracture probability but does not incorporate falls or MG-specific functional impairment. To... |
41598284 | A Paradigm Shift in Microbial Protein Manufacturing. | Against the backdrop of the global protein crisis and the textural limitations of alternative proteins, microorganisms are increasingly recognized as versatile structural materials to address these challenges. This review systematically analyzes three key microbial strategies: employing mycelial solid-state fermentatio... |
41598040 | The 15th Anniversary of <i>Materials</i>-Recent Advances in Materials Chemistry. | For a period of 15 years from its foundation in 2008, <i>Materials</i> has provided its readership with superior content, the production of which has been undertaken by active researchers in the field of material science [...]. |
41597221 | Peptide Arrays as Tools for Unraveling Tumor Microenvironments and Drug Discovery in Oncology. | Peptide arrays represent a powerful tool for investigating a wide application field for biomedical questions. This review summarizes recent applications of peptide chips in oncology, with a focus on tumor microenvironment, metastasis, and drug mechanism of action for various cancer types. These high-throughput platform... |
41596896 | γ-Cyclodextrin/Genistein Inclusion Complex Catalyzes GPx4-Mediated Reduction of Organic/Inorganic Peroxides: Based on SERS and In Silico Research. | Organic and inorganic peroxides can induce intracellular redox homeostasis. In this study, a γ-cyclodextrin/genistein inclusion complex (γ-CD/GEN) was constructed to systematically elucidate the molecular mechanism by which it catalyzes GPx4-mediated peroxide reduction. The results indicate that the incorporation of γ-... |
41596496 | From Emissions to Assets: Sustainable Technologies for CO<sub>2</sub> Capture, Conversion, and Integrated Strategies. | Addressing the growing threat of climate change requires urgent and sustainable solutions for managing carbon dioxide (CO<sub>2</sub>) emissions. This review investigates the latest advancements in technologies for capturing and converting CO<sub>2</sub>, with a focus on approaches that prioritize energy efficiency, en... |
41596165 | Cold Shock Protein B as an Alternative to DMSO for Oocyte Vitrification. | Dimethyl sulfoxide (DMSO) is widely utilized in the vitrification of oocytes, but DMSO exhibits concentration-dependent toxicity, which can compromise oocyte developmental potential by disrupting key cellular processes. This study reports the first successful use of cold shock protein B (CspB protein) as a substitute f... |
41595712 | Mutational Landscape Analysis of BRCA1/2 and Identification of Extracellular-Vesicle-Related Biomarkers in Triple-Negative Breast Cancer. | <b>Background</b>: Triple-negative breast cancer (TNBC), defined by the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER-2) expression, is associated with increased <i>BRCA1/2</i> mutation rates. Extracellular vesicles (EVs) play a pivotal role in TNBC pro... |
41595715 | Rationally Designed Dual Kinase Inhibitors for Management of Obstructive Sleep Apnea-A Computational Study. | <b>Background/Objectives:</b> Obstructive sleep apnea (OSA) affects approximately 1 billion adults worldwide with extensive comorbidities, including cardiovascular disease, metabolic disorders, and cognitive decline, yet pharmacological therapies remain limited. Conventional bottom-up omics approaches identify numerous... |
41594877 | Molecular Insights into Widespread Pseudouridine RNA Modifications: Implications for Women's Health and Disease. | Pseudouridine (Ψ), the most abundant RNA modification, plays essential roles in shaping RNA structure, stability, and translational output. Beyond cancer, Ψ is dynamically regulated across numerous physiological and pathological contexts-including immune activation, metabolic disorders, stress responses, and pregnancy-... |
41594689 | Antifungal Activity of Natural Thymol: Advances on Molecular Mechanisms and Therapeutic Potential. | Currently, the increased incidence of invasive fungal infections globally is posing a significant challenge to public health. Due to drug resistance issues, the clinical efficacy of existing antifungal drugs is seriously insufficient, while new drug development progresses slowly. Consequently, there is an urgent need t... |
41594686 | Discovery of Novel Minor Steviol Glycoside from the <i>Stevia rebaudiana</i>: Structural Characterization and Proposed Biosynthetic Pathway of Rebaudioside <i>D17</i>. | A novel steviol glycoside, Rebaudioside <i>D17</i>, was identified from the leaf extract of <i>Stevia rebaudiana</i> Bertoni. This compound features a rare β-1→4 glycosidic linkage between two glucose units at the C19 position, distinguishing it from its structural isomer, Rebaudioside <i>D</i>. The aim of this study w... |
41594246 | A Real-Time Dynamic Warning Method for MODS in Trauma Sepsis Patients Based on a Pre-Trained Transfer Learning Algorithm. | <b>Objectives:</b> Multiple organ dysfunction syndrome (MODS) is a serious, prognostically poor complication in trauma sepsis. We developed an interpretable, multicenter-validated prediction model to enable early, individualized risk assessment and guide timely care. <b>Methods:</b> Using MIMIC-IV and eICU data, we bui... |
41591027 | Assessing Hydrolytic Activity of Surfactant-Based Nanozymes: Methodological and Kinetic Considerations. | The review critically discusses the methodological approach used to characterize the mechanism and to assess kinetic parameters in catalytic processes promoted by surfactant-based nanozymes. Using the hydrolysis of carboxylic and phosphoric esters as model reactions, it quantitatively analyzes several examples in which... |
41590313 | A Luminol-Based, Peroxide-Free Fenton Chemiluminescence System Driven by Cu(I)-Polyethylenimine-Lipoic Acid Nanoflowers for Ultrasensitive SARS-CoV-2 Immunoassay. | The reliance on unstable hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) adversely affects the robustness and simplicity of chemiluminescence (CL)-based immunoassays. We report a novel external H<sub>2</sub>O<sub>2</sub>-free Fenton CL system integrated into a highly sensitive non-enzymatic immunoassay for the detection... |
41590314 | Two-Dimensional Carbon-Based Electrochemical Sensors for Pesticide Detection: Recent Advances and Environmental Monitoring Applications. | Pesticides have been widely applied in agricultural practices over the past decades to protect crops from pests and other harmful organisms. However, their extensive use results in the contamination of soil, water, and agricultural products, posing significant risks to human and environmental health. Exposure to pestic... |
41584036 | Dysregulation of SRSF11 in Cancer: Mechanistic Insights and Biomarker Potential for Diagnosis and Therapy. | Serine/arginine-rich splicing factor 11 (SRSF11) is an RNA-binding regulator that modulates alternative splicing and RNA metabolism in a context-dependent manner across selected malignancies. Evidence from colorectal, hepatocellular, gastric, glioma, and a few other cancers indicates that SRSF11 participates in cell-cy... |
41574534 | Cyclodextrin-based Advances in Cancer Drug Delivery: Revolutionizing Oncological Therapeutics. | Cancer remains a formidable global health challenge, necessitating innovative strategies to enhance therapeutic outcomes. Cyclodextrins (CDs), cyclic oligosaccharides with a unique hydrophilic exterior and a hydrophobic cavity, have emerged as versatile tools in drug delivery, offering solutions to challenges such as p... |
41570419 | A molecular dynamics study of PIM<sub>2</sub> lipid bilayer membranes. | Developing simplified yet representative models of the complex Mycobacterium tuberculosis inner membrane is crucial for advancing Molecular Dynamics of this pathogen. Phosphatidyl-myo-inositol dimannosides (PIM<sub>2</sub>), one of the most abundant lipids in this membrane, provides an ideal basis for such a model. In ... |
41568355 | From shield to spear: Charge-reversible nanocarriers in overcoming cancer therapy barriers. | Cancer remains a significant global health burden, responsible for 16.8% of all deaths and 30.3% of premature mortality due to noncommunicable diseases, and continues to be one of the leading causes of death worldwide despite medical progress. Conventional treatment methods such as surgery, chemotherapy, and radiothera... |
41551136 | Towards Safer Water: A Low-Cost Disposable Electrochemical Sensor for Bisphenol A Using La<sub>2</sub>Sn<sub>2</sub>O<sub>7</sub> Nanostructures. | Bisphenol A (BPA), a widely used industrial chemical, persists in aquatic environments and poses serious endocrine-disrupting risks to ecosystems and human health. This study presents a highly sensitive, selective electrochemical sensor using lanthanum stannate (La<sub>2</sub>Sn<sub>2</sub>O<sub>7</sub>), a rare-earth ... |
41544788 | Multi-active-site UiO-66-NO<sub>2</sub>-based carboxymethyl cellulose-sodium alginate composite aerogel: Efficient adsorption of methylene blue and methyl orange. | This study developed a multi-adsorption-site UiO-66-NO<sub>2</sub> gel@CMC/SA (carboxymethyl cellulose and sodium alginate) composite using an in-situ growth approach. The CMC/SA aerogel carrier was combined with a metal-organic gel (MOG) to enable the highly effective removal of methylene blue (MB) and methyl orange (... |
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