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41858579 | Combinatorial Anti-Mitotic Activity of Loratadine/5-Fluorouracil Loaded Zein Tannic Acid Nanoparticles in Breast Cancer Therapy: In silico, in vitro and Cell Studies. | <h4>Introduction</h4>Chemotherapy, the first approach in breast cancer management, is limited owing to systemic toxicity and drug resistance. For instance, 5-fluorouracil in recommended doses cause severe side effects, highlighting the urgent necessity of finding more effective and safer combinations. Hence, this study... |
41858577 | Novel Dual Strategy Based on EPR/AT for Optimizing Therapeutic Effect by Improving Drug Delivery System Physicochemical Properties and Regulating TME. | The clinical advancement of cancer nanomedicine is significantly hindered by its limited accumulation in tumors, a key factor behind the frequent failure of nanodrugs in clinical trials. The effectiveness of these nanodrugs is closely tied to their route of administration, whether oral, transdermal, intravenous, or int... |
41858572 | Nano-Enabled Therapeutics: Novel Strategies for Preeclampsia Treatment. | Preeclampsia (PE), a pregnancy-specific disorder characterized by hypertension and placental dysfunction, remains a leading cause of maternal and fetal morbidities worldwide. Recent advances in nanomedicine offer promising therapeutic strategies by targeting placental pathologies. Studies have demonstrated that in PE m... |
41858570 | Nanoreagents Against the Blood-Testis Barrier: A Strategy for Diagnosing and Treating Male Reproductive System Diseases. | Male reproductive health represents a critical yet challenging area of medical science, where conventional diagnostics and therapies are often limited by physiological barriers-particularly the blood-testis barrier (BTB)-and the complex etiology of disorders such as infertility, prostate cancer, and erectile dysfunctio... |
41835226 | A general protocol for engineering metal-oxo-chain standing frameworks. | Infinite metal-oxo metal-organic frameworks (MOFs) are recognized as promising platforms for developing all-round high-performance catalysts for both academic and industrial significance. Nevertheless, engineering infinite metal-oxo architectures typically requires harsh synthetic conditions, often yielding microcrysta... |
41732484 | Fenton-like oxidation and KOH activation on the CO<sub>2</sub> adsorption performance of wood-based hierarchical porous carbon. | Biomass-derived porous carbon is a promising low-cost candidate for CO<sub>2</sub> capture, yet its pore structure and adsorption performance require optimization. Herein, poplar wood powder was pretreated via Fenton-like oxidation (Fe<sup>3+</sup>/H<sub>2</sub>O<sub>2</sub>) followed by potassium hydroxide (KOH) activ... |
41717008 | Advancements in biomass-derived single-metal-doped nanostructured carbon electrocatalysts and electrode materials for rechargeable zinc-air batteries. | Rechargeable zinc-air batteries (RZABs) are vital for advancing sustainable energy storage technologies. Renewable single-metal-doped nanostructured carbon from biomass offers promising electrocatalysts and electrodes, enabling efficient oxygen reactions for sustainable battery technologies. This review exemplifies the... |
41696507 | Metal Ion-Specific Modulation of Network Connectivity and Defects in Poly(ethylene glycol)-Peptide Conjugate Assemblies and Hydrogels. | Self-assembling peptide-polymer conjugates offer a versatile platform to engineer nanostructures with tunable morphology and functions. Here we show that alternating phenylalanine-histidine pentapeptide units, conjugated to a short linear poly-(ethylene glycol), show pH-induced assembly into β-sheet nanofibers that act... |
41694582 | The SOX10-ACAT2-Cholesterol Synthesis Axis Is Required for Melanoma Proliferation. | Research on cholesterol and its metabolic pathways has catalyzed the development of anticancer drugs targeting cholesterol synthesis. However, the cholesterol metabolic state in melanoma remains poorly characterized. In this study, we found that total cholesterol levels and the expression of acetyl-CoA acetyltransferas... |
41684669 | Structural Studies of Fourth-Generation EGFR Inhibitors Reveal Insights into Selective T790M and C797S Targeting. | Inhibitors targeting mutant EGFR remain a persistent need in combating drug resistance in non-small cell lung cancer. To better understand the molecular factors involved in targeting T790M and C797S mutations, we determined X-ray cocrystal structures of fourth-generation inhibitors BI-8128 and BI-4732. Analysis from mo... |
41679848 | Orange peel-derived pectin/cellulose nanofibril hydrogel reinforced by Eu-MOF for simultaneous adsorption and detection of levofloxacin. | Orange peel is an abundant polysaccharide-rich agro-industrial residue that is often discarded, causing resource loss and environmental burden. Here, we valorize orange peel-derived pectin into a mechanically robust and photostable fluorescent hydrogel (EuCPH) by embedding uniformly dispersed Europium-based metal-organ... |
41675048 | A review on flexible self-healing thermoelectric devices. | The rapid development of wearable and portable electronics has intensified the demand for flexible thermoelectric devices that can convert human body heat into electricity. In practical use, however, such devices suffer from performance degradation caused by mechanical damage and thermal stress, which severely limit th... |
41658086 | Natural Chlorin e<sub>6</sub> Derivative Containing a Cationic Dimethyl Piperazinyl Moiety for Efficient Photodynamic Therapy of Cancer. | This paper focuses on the behavior of two chlorophyll-type semisynthetic photosensitizers for antitumor photodynamic therapy, which, in our opinion, meet the known criteria associated with efficient photodynamic treatment of superficial malignancies. These natural light-sensitive agents obtained from the <i>Spirulina p... |
41658075 | Cocrystal Formation of Quercetin and Nutraceutical Coformers via a Facile Technique with Improved Solubility and Biological Properties. | Cocrystallization has emerged as an effective strategy to improve the physicochemical and pharmaceutical properties of bioactive compounds. Here, we prepared novel cocrystals of quercetin (Que) and nutraceutical coformers, i.e., vitamin B6, inositol and l-carnitine, by using slurry methods. The cocrystals were characte... |
41638952 | Phenylboronic acid modification and small-molecule assembly to enhance the safety of resiquimod and its synergistic anti-tumor efficacy with paclitaxel. | To overcome the systemic toxicity and poor tumor targeting of the TLR7/8 agonist R848, this study developed a derivative by attaching a phenylboronic acid (PBA) group to R848. The resultant R848-PBA retain the immune activation of R848, easily assembly with indocyanine green (ICG) into nanoparticles (R-P@ICG NPs), whic... |
41626319 | Nanoengineered polyglutamic acid fertilizers via self-assembly for efficient tomato growth. | <h4>Introduction</h4>Polyglutamic acid (γ-PGA) is a promising biostimulant for enhancing crop growth and stress resistance, while its agricultural application is limited by poor leaf retention, low mobility within plants, and susceptibility to rain wash-off.<h4>Methods</h4>This study developed PGA nanofertilizers via a... |
41625748 | Current status and future prospects of nanocarrier-mediated miRNA delivery for osteoarthritis therapy. | Osteoarthritis (OA) is a common degenerative joint disease whose pathogenesis involves multiple pathways, including inflammatory responses, cartilage matrix metabolism, cell proliferation, and apoptosis. Currently, effective clinical treatments are lacking. MicroRNAs (miRNAs) are associated with the pathogenesis of OA ... |
41625339 | Glutathione and neurodegenerative diseases: immunopharmacological implications. | Neurodegenerative diseases are characterized by progressive neuronal dysfunction, often accompanied by chronic inflammatory states and redox imbalance within the central nervous system (CNS). Glutathione (GSH), a key regulator of oxidative stress and cellular immunity, has a critical role in modulating the functional s... |
41624884 | Identification and validation of an endotoxin tolerance-based prognostic model with therapeutic insights in sepsis. | <h4>Background</h4>Sepsis outcomes remain difficult to predict because immune trajectories are heterogeneous and dynamically shift from early activation to immunosuppression. Endotoxin tolerance (ET) in circulating monocytes/macrophages is a key mechanism of sepsis-associated immunosuppression but has not been systemat... |
41624832 | cGAS-STING signaling: a therapeutic target in inflammatory bowel disease and related colorectal cancer. | The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway is a critical mechanism of DNA sensing in innate immunity. Activation of this pathway can induce the production of interferons and proinflammatory cytokines. In the intestine, this pathway exhibits bidirectional regulatory prope... |
41624772 | Regulatory QTLs affecting miRNA-mRNA interactions in cancer: mechanisms, methods, and clinical implications. | MicroRNAs (miRNAs) are post-transcriptional regulators that play essential roles in cancer initiation, progression, and therapy response. Single nucleotide polymorphisms (SNPs) that affect miRNA-mRNA interactions, termed regulatory quantitative trait loci (regQTLs), have emerged as critical modulators of gene expressio... |
41624191 | Non-volatile metabolomics analysis of heating withering method for processing white tea from Longjing 43 tea variety by UHPLC-Q-TOF/MS. | Withering is a crucial step in the production of white tea. However, the non-volatile metabolomic profile of white tea produced from the Longjing 43 cultivar using heated withering methods has not been fully elucidated. This study investigated the effect of a novel heated withering process on the taste quality and non-... |
41613582 | Three-dimensional culture of tumor cells (Review). | While conventional two-dimensional (2D) cell cultures and animal models have been cornerstone technologies in cancer research, they possess limitations in replicating human tumor pathophysiology. Notably, 2D models fail to capture key tissue-level architecture and cell-cell interactions, whereas animal models are often... |
41600394 | Portable Raspberry Pi Platform for Automated Interpretation of Lateral Flow Strip Tests. | Paper-based rapid tests are widely used in point-of-care diagnostics due to their simplicity and low cost. However, their application in quantitative analysis remains limited. In this work, a nucleic acid lateral flow assay (NALFA) was integrated with an automated image acquisition system built on a Raspberry Pi platfo... |
41600069 | Recent Advances in Transcription Factor-Mediated Regulation of Salvianolic Acid Biosynthesis in <i>Salvia miltiorrhiza</i>. | <i>Salvia miltiorrhiza</i> Bunge is a traditional Chinese medicinal plant whose roots are rich in water-soluble phenolic acids. Rosmarinic acid and salvianolic acid B are representative components that confer antibacterial, antioxidant, and cardio-cerebrovascular protective activities. However, these metabolites often ... |
41599519 | Preparation and High-Sensitivity Thermochromic Performance of MXene-Enhanced Cholesteric Liquid Crystal Microcapsule Textiles. | To mitigate the attenuation of color-change sensitivity in cholesteric liquid crystals (CLCs) post-microencapsulation, this study developed MXene-reinforced thermochromic textiles. Monolayer/few-layer MXene nanosheets were fabricated via an etching-intercalation-dispersion approach, while cholesteric liquid crystal mic... |
41599355 | Beyond the Solvent: Engineering Ionic Liquids for Biomedical Applications-Advances, Challenges, and Future Directions. | Ionic liquids (ILs) have emerged as multifunctional compounds with low volatility, high thermal stability, and tunable solvation capabilities, making them highly promising for biomedical applications. First explored in the late 1990s and early 2000s for enhancing the thermal stability of enzymes, antimicrobial agents, ... |
41599218 | Structure-Based Prediction of Molecular Interactions for Stabilizing Volatile Drugs. | <b>Background/Objectives</b>: The high volatility of volatile drugs significantly restricts their clinical applicability. Although excipients capable of strong interactions can reduce volatilization, conventional screening methods rely on empirical trial-and-error, resulting in low efficiency and high resource consumpt... |
41599220 | Harnessing Phytochemicals and Nanotechnology Synergy for Molecular, Epigenetic, and Microbiota-Driven Regulation in Type 2 Diabetes Mellitus. | Type 2 diabetes mellitus (T2DM) is a multifaceted metabolic disorder marked by impaired insulin action, pancreatic β-cell dysfunction, and the involvement of several interconnected mechanisms, including inflammation, oxidative stress, and epigenetic alterations. Despite progress in conventional therapies, achieving dur... |
41599222 | Effective Non-Invasive Delivery of Epigenetic Drugs Using Functionalized Accessory Unit Conjugates. | Epigenetics involves heritable changes in gene expression-such as DNA methylation (5-methylcytosine; 5mC), histone modifications, and regulation by non-coding RNAs at the mRNA translation level-without altering the underlying DNA sequence. As targeting these mechanisms enables intervention at the root cause of disease ... |
41597710 | "Hiding in Plain Sight": A Retrospective Clinical and Microbiological Review of Vancomycin-Dependent Enterococci at a Tertiary Care Centre-A Case Report. | Vancomycin-resistant <i>Enterococci</i> (VRE) are established nosocomial pathogens; however, vancomycin-dependent <i>Enterococci</i> (VDE) represent a rare and underrecognized phenomenon. These organisms paradoxically require vancomycin for growth due to mutations in cell wall precursor synthesis. Limited awareness and... |
41597233 | Chronic In Vivo CRISPR-Cas Genome Editing: Challenges, Long-Term Safety, and Outlook. | CRISPR/Cas systems have transformed molecular medicine, yet the field still lacks principled guidance on when transient editing suffices versus when sustained exposure through in vivo viral delivery is necessary and how to keep prolonged exposure safe. Notably, EDIT-101 was designed for a permanent edit in post-mitotic... |
41596537 | Molecular Aspects of Viral Pathogenesis in Emerging SARS-CoV-2 Variants: Evolving Mechanisms of Infection and Host Response. | Although the SARS-CoV-2 pandemic no longer poses a global emergency, the virus continues to diversify and acquire immunoevasive properties. Understanding the molecular pathways that shape SARS-CoV-2 pathogenesis has become essential. In this paper, we summarize the most recent current evidence on how the spike protein ... |
41596525 | MicroRNAs in Esophageal Cancer: Implications for Diagnosis, Progression, Prognosis and Chemoresistance. | Esophageal cancer (EC), including esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC), remains a highly lethal disease because of its late diagnosis, significant biological heterogeneity, and frequent resistance to therapy. Growing evidence indicates that microRNAs (miRNAs) are key posttranscr... |
41596513 | Molecular and Cellular Mechanisms Underlying Domoic Acid-Induced Neurotoxicity and Therapeutic Drugs: A Comprehensive Review. | Domoic acid (DA) is a neurotoxic terpenoid compound produced by certain marine algae. It accumulates through the food web and poses a significant threat to humans and animals by selectively targeting hippocampal neurons, leading to neuronal degeneration, necrosis, and subsequent memory impairment. The primary mechanism... |
41595191 | Poliovirus Receptor as a Potential Target in Gastric Signet-Ring Cell Carcinoma for Antibody-Drug Conjugate Development. | <h4>Background</h4>Gastric signet-ring cell carcinoma (GSRCC) is a distinct subtype of gastric cancer characterized by unique biological features, leading to low rates of early diagnosis, poor prognosis, and limited response to chemotherapy and immunotherapy. Effective targeted therapies for GSRCC remain scarce. Given ... |
41594888 | Adsorption Characterization and Mechanism of a Red Mud-<i>Lactobacillus plantarum</i> Composite Biochar for Cd<sup>2+</sup> and Pb<sup>2+</sup> Removal. | Pb<sup>2+</sup> and Cd<sup>2+</sup> represent common heavy metal contaminants in aquatic environments, posing significant risks to ecosystem stability and human health. To develop efficient adsorbents for removing Cd<sup>2+</sup> and Pb<sup>2+</sup> while achieving resource utilization of industrial by-products (red mu... |
41594697 | Microglia, Astrocytes, and Oligodendrocytes in Parkinson's Disease: Neuroinflammatory Crosstalk and Emerging Therapeutic Strategies. | Parkinson's disease (PD) is a progressive neurodegenerative disorder marked by the degeneration of dopaminergic neurons in the substantia nigra, resulting in cardinal motor symptoms such as tremor, rigidity, and bradykinesia. Neuroinflammation is increasingly recognized as a central driver of PD onset and progression i... |
41591035 | In Situ Growth of Metal-Organic Frameworks (MOFs) Within Porous Silicon Carbide (p-SiC) for Constructing Hierarchical Porous Composites. | Metal-organic frameworks (MOFs) typically exist in the form of powders or dispersed crystals, which limits their direct application in practical engineering scenarios that require monolithic structures and processability. To address this issue, the present study successfully anchored MOF (zeolitic imidazolate framework... |
41591031 | Study on the Efficiency and Mechanism of a Novel Copper-Based Composite Material Activated by Supramolecular Self-Assembly for Degrading Reactive Red 3BS. | To address the challenge of treating refractory organic dyes in textile wastewater, this study synthesized a novel copper-based composite material (designated MEL-Cu-6HNA) via a supramolecular self-assembly-pyrolysis pathway. Its core component consists of CuO/Cu<sub>2</sub>O(SO<sub>4</sub>), which was applied to effic... |
41590807 | Biomaterials for Improving Skin Penetration in Treatment of Skin Cancer. | Skin cancer is among the most common malignancies worldwide, posing a significant societal burden due to its increasing incidence and its limited responsiveness to conventional topical therapies. Treatment is challenged by the presence of the skin barrier which restricts drug penetration. This review discusses the stru... |
41590812 | Advanced Biomaterials for Craniofacial Tissue Regeneration: From Fundamental Mechanism to Translational Applications-A Scoping Review. | Recent advances in biomaterials, immunomodulation, stem cell therapy, and biofabrication are reshaping maxillofacial surgery, shifting reconstruction paradigms toward biologically integrated and patient-specific tissue regeneration. This review provides a comprehensive synthesis of current and emerging strategies for b... |
41590809 | Electrostatic Patterning of Nanofibrous Microcapsules for Three-Dimensional Cell Culture. | Three-dimensional biomaterial scaffolds with controlled geometry and surface nanoarchitecture are essential for advancing polymer processing strategies in tissue engineering. Conventional electrospinning generates nanofibrous structures but has limited ability to reproduce defined three-dimensional shapes or achieve hi... |
41590808 | Allomelanin: A Promising Alternative to Polydopamine for Bioapplications. | Allomelanin is a natural class of melanin found mainly in fungi and derived from nitrogen-free precursors such as 1,8-dihydroxynaphthalene (1,8-DHN). Despite its biological relevance, allomelanin remains significantly less explored than other synthetic melanin analogs, particularly compared to polydopamine, a synthetic... |
41590741 | Marine Bacteria as a Source of Antibiotics Against <i>Staphylococcus aureus</i>: Natural Compounds, Mechanisms of Action, and Discovery Strategies. | <i>Staphylococcus aureus</i> is a major opportunistic pathogen responsible for a wide spectrum of human infections, including severe and difficult-to-treat cases. The emergence of multidrug-resistant strains limits the efficacy of conventional antibiotic therapies and poses a significant global public health challenge.... |
41590099 | Oil-Water Biphasic Metal-Organic Supramolecular Gel for Lost Circulation Control: Formulation Optimization, Gelation Mechanism, and Plugging Performance. | Lost circulation in oil-based drilling fluids (OBDFs) remains difficult to mitigate because particulate lost circulation materials depend on bridging/packing and gel systems for aqueous media often lack OBDF compatibility and controllable in situ sealing. A dual-precursor oil-water biphasic metal-organic supramolecular... |
41590100 | Impact of Gel-Derived Morphology-Controlled UiO-66/Cellulose Nanofiber Composite Separators on the Performance of Aqueous Zinc-Ion Batteries. | Zinc dendrite growth and side reactions remain critical challenges hindering the advancement of aqueous zinc-ion batteries (AZIBs). This study proposes a gel-based strategy for designing high-performance separators by regulating the crystal morphology of the metal-organic framework UiO-66 within a cellulose nanofiber (... |
41585345 | Exosomal miRNA-218-5p derived from low-passage dermal papilla cells modulates hair follicle growth and development. | Exosomes are nanoscale particles that participate in multiple biological processes and are secreted by various cell types. Exosomes derived from dermal papilla cells (DPC-Exos) regulate hair follicle (HF) growth and development. In this study, HF development-related genes were significantly expressed in low-passage der... |
41573119 | Curvature-emergent supramolecular polymerization of a porphyrin dyad with a scissor-shaped motif. | Curvature has recently emerged as a key structural parameter that dictates the pathway and topology of supramolecular polymerization. We previously showed that scissor-shaped azobenzene dyads, dimerized through a xylylene spacer bearing long alkyl chains, undergo folding-induced self-assembly to yield curvature-derived... |
41567964 | Expanding the chemical space of peptides <i>via</i> biocompatible tryptophan C7-arylation. | Late-stage functionalization of peptides and amino acids is a powerful strategy for modulating biological activity and enabling targeted molecular imaging, offering a promising route for expanding the chemical space of peptides. Here, we report a Rh-catalyzed, P(iii)-directed C7-selective arylation of tryptophan residu... |
41562866 | Female Aging Affects Coilin Pattern in Mouse Cumulus Cells. | Cumulus cells (CCs) are a distinct population of granulosa cells (GCs) that surround the developing and ovulated mammalian oocyte. The features of their structural organization and the expression pattern of key genes significantly affect oocyte viability. Changes in the functional activity of the nucleus are often expr... |
41551989 | Oral microbiome-SASP-aging axis: mechanisms and targeted intervention strategies for age-related diseases. | <h4>Background</h4>Global demographic aging is intensifying the burden of age-related diseases. Cellular senescence and the accompanying senescence-associated secretory phenotype (SASP) act as key drivers of disease progression by mediating chronic inflammation. As the second largest microbial community in the human bo... |
41551913 | Coordination-Driven Nanoarchitectures for Smart Packaging Strategies in Poultry Preservation. | The poultry industry faces major challenges in preserving meat freshness and safety due to high water activity, rapid microbial growth, and oxidative spoilage. Traditional methods such as vacuum sealing and antioxidants are insufficient, as they cannot effectively suppress anaerobic pathogens and lack real-time freshne... |
41551018 | Exploiting intracellular oncogenic proteins to release cytotoxins. | The success of antibody-drug conjugates has demonstrated the value of targeted delivery strategies for cytotoxic molecules. However, many oncogenic drivers remain inaccessible to antibodies due to their intracellular location, and these drivers are currently mainly addressed using small molecule inhibitors. This work e... |
41550830 | Microplasma-assisted green synthesis of glucose-stabilized silver nanoparticles: a dual-functional platform for SERS detection and synergistic reduction of binary dyes. | A rapid and environmentally sustainable approach for synthesizing glucose-stabilized silver nanoparticles (G-AgNPs) was developed using an atmospheric-pressure microplasma process that completely eliminates the need for conventional chemical reductants and surfactants. The synergistic interaction between plasma-generat... |
41550822 | Solvent-mediated extraction of disperse dyes from polyester: correlating Cyrene extraction yields with molecular topological and chemical descriptors. | The desorption of disperse dyes from synthetic textiles remains a critical challenge in sustainable textile processing, particularly when targeting structurally diverse dye classes. This study examines the structure-property relationships governing solvent-mediated dye extraction using Cyrene™, focusing on azo and anth... |
41550834 | Novel self-assembled cobalt sulfide nanorods/reduced graphene oxide as an efficient nano-catalyst for dual sensing of 4-nitrophenol. | A sensitive and sustainable electrochemical sensor based on cobalt sulfide nanorods/reduced graphene oxide (CoS-NR/rGO) was fabricated for the detection of 4-nitrophenol (4-NP). rGO derived from recycled plastic waste, served as a conductive and eco-friendly matrix, while CoS-NR were synthesized <i>via</i> a simple che... |
41550823 | Emerging trends and structure-activity insights of Schiff base-lanthanide complexes as antibacterial agents. | The rapid escalation of microbial resistance has accelerated the search for next-generation antibacterial agents with novel mechanisms of action. Schiff bases and their lanthanide complexes have emerged as promising candidates due to their tunable structures, coordination versatility and enhanced bioactivity upon metal... |
41550817 | Sahara Desert sand "Chitligsan": characterisation and assessment of antibacterial activity and cytotoxicity. | Antimicrobial resistance presents a significant global health concern, rendering antimicrobial therapies less effective and complicating the management of infectious diseases. To address this challenge, the utilisation of natural alternatives, particularly metal oxide-based nanomaterials, has emerged as a promising str... |
41550807 | Efficient synthesis, dual anti-tubercular and antioxidant activity of triazole-acetophenone derivatives: enhanced efficacy <i>via</i> esterification and quantum mechanical validation of CYP121 binding. | A series of twelve novel triazole-based acetophenone derivatives (3a-3f and 4a-4f) was efficiently synthesized <i>via</i> a catalyst-free 1,3-dipolar cycloaddition reaction, integrating a known CYP121 inhibiting scaffold with dual anti-tubercular and antioxidant properties. The anti-tubercular screening demonstrated th... |
41550799 | CHA-driven SERS-nanoenzyme sensor for ultra-sensitive diagnosis of gastric precancerous lesions. | Early identification and timely intervention of precancerous lesions of gastric cancer are the core strategies to block their malignant transformation into gastric cancer (GC). This study developed a dual functional sensor that combined surface-enhanced Raman scattering (SERS) activity and nanoenzyme catalytic properti... |
41550570 | Nanomedical approaches to deplete intracellular glutathione in oncology. | Glutathione (GSH) plays a critical role in maintaining redox homeostasis and conferring chemoresistance to cancer cells, making it an attractive target for therapeutic intervention. Recent advances in nanomedicine have led to the development of diverse nanostructures capable of depleting GSH, either stoichiometrically ... |
41550556 | Interfacial photocycloaddition polymerization: a synthetic approach for structurally functionalized degradable polymer particles from naturally derived monomers. | Industrially relevant polymer capsules-structurally functionalized particulate materials that have shown promise for application in cosmetics, fragrances, and agrochemicals-typically comprise non-degradable synthetic polymers that cause marine microplastic pollution, which is a global environmental issue. This paper de... |
41547525 | A comprehensive discussion on analytical method development and validation of a USP type-IV dissolution method for dexamethasone in a combination ophthalmic suspension with povidone-iodine. | Antimicrobial resistance resulting from the widespread use of topical antibiotics has accelerated the need for non-antibiotic strategies in ocular therapy. Povidone-iodine (PVP-I) offers broad antimicrobial activity without inducing resistance, while dexamethasone provides potent anti-inflammatory effects, making their... |
41547494 | Bioconjugates for improved delivery of oligonucleotide therapeutics to the central nervous system. | Oligonucleotide therapeutics, including antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs), have gained increasing attention as a novel modality for gene-targeted interventions for central nervous system (CNS) disorders, particularly in the context of rare and inherited neurological conditions. By co... |
41544394 | Three-channel microfluidic PEC aptasensor driven by S-scheme heterojunction BiOBr@CdIn<sub>2</sub>S<sub>4</sub> for integrated detection of three mycotoxins. | The co-occurrence of mycotoxins in food represents a significant threat to human health, with aflatoxin B1 (AFB1), fumonisin B1 (FB1), and ochratoxin A (OTA) being among the most hazardous examples. Consequently, the development of reliable, multiplexed, and ultrasensitive methods for their integrated detection is esse... |
41543272 | Non-Viral CRISPR carriers: transient delivery with lasting effects. | CRISPR-Cas9 has revolutionized the field of genome editing. While conventional gene supplementation therapies and the market of related gene therapy products are dominated by viral vectors, non-viral delivery strategies are increasingly being explored for <i>in vivo</i> CRISPR applications. Given the permanent nature o... |
41540790 | Dopant-Mediated Modulation of Charge-Transfer Pathways in Metal-Organic Frameworks: A Quantum Dynamics Perspective. | Metal substitution offers a powerful route to enhance charge separation in metal-organic framework (MOF) photocatalysts, yet the mechanism remains elusive. Using ab initio adiabatic and nonadiabatic molecular dynamics, we show that Ce- and Ti-doped UiO-66-NH<sub>2</sub>(Zr) generate localized electron-polaron states wi... |
41540763 | Activating Lithium Titanate for High-Performance and Stable Electrochemical Direct Lithium Extraction. | Direct lithium extraction (DLE) from brine using electrosorption processes offers an environmentally sustainable alternative to evaporation-based mining, but its advancement has been hindered by the lack of electrode materials that combine high selectivity, fast kinetics, and long-term stability. Lithium titanate (LTO)... |
41540755 | A ZrO<sub>2</sub>-Based Ternary Photocatalyst with Highly Reduced Defects for Visible-Light-Driven Hydrogen Production. | Photocatalytic hydrogen production has emerged as one of the most promising strategies for addressing current energy and ecological environment issues. Optimizing charge transport pathways and reducing internal defects in semiconductor catalysts are crucial to enhancing catalytic performance. Herein, a ZrO<sub>2</sub>-... |
41540742 | In Situ Monitoring of Cathepsin B-Induced Mitochondrial Permeabilization by Raman Spectroscopy. | Cathepsin B is a lysosomal cysteine protease that plays an important role in multiple forms of programmed cell death. The leakage of cathepsin B from the lysosome is believed to be involved in BID truncation, resulting in mitochondrial outer membrane permeabilization (MOMP). Herein, we report that cathepsin B can direc... |
41540725 | Generic Vitrification of Prototype Metal-Organic Frameworks Linked by Rigid Dicarboxylate Linkers. | Vitrifying crystalline metal-organic frameworks (MOFs) is an emerging route to creating processable glassy materials with novel functions. However, a vast portion of MOFs, such as seminal MOF-5, are constructed from rigid aromatic dicarboxylate linkers. While essential for reticular design, these aromatic dicarboxylate... |
41540669 | Effects of Liposome Composition and Size on Protein Corona Formation: Competitive Replacement of Abundant Proteins by High-Affinity Proteins on the Liposome Surface. | Plasma proteins (human serum albumin, immunoglobulin gamma-1, complement C3, and fibrinogen) are simulated with 26 and 36 nm-sized cationic, anionic, and zwitterionic liposomes in water using coarse-grained models. Proteins, initially placed randomly around a liposome, adsorb more significantly onto charged liposomes t... |
41540659 | Nano-Engineered Titanium Implants Loaded With Gingival Fibroblasts-Derived Microvesicles Enhance Early Osseointegration And Soft Tissue Attachment In Vivo. | Titanium dental implants require both reliable osseointegration and peri-implant soft tissue seal formation to ensure long-term success. While osseointegration has been widely studied, strategies to optimize soft tissue healing remain underexplored. In this study, we developed titania nanopore (TNP) implant surfaces fu... |
41540647 | Localized Active H* Enrichment by Cobalt Molecular Catalysts for Enhanced Electrocatalytic Nitrate Reduction. | Electrochemical nitrate reduction (NO<sub>3</sub> <sup>-</sup> RR) offers a sustainable route for ammonia (NH<sub>3</sub>) synthesis, simultaneously enabling pollutant remediation and resource recovery. The efficiency of NO<sub>3</sub> <sup>-</sup> RR relies on regulating the hydrogenation behaviors of active sites to ... |
41540627 | Inter-Doping ZrO<sub>2</sub>-5.5RuO<sub>2</sub> Heterostructures for Enhanced Efficiency and Stability in Acidic Oxygen Evolution. | Acid water electrolysis represents a crucial technology for the sustainable production of hydrogen. However, acidic media and high oxidation potential can lead to oxidative dissolution of catalysts (e.g., RuO<sub>2</sub> → soluble RuO<sub>4</sub>), resulting in a rapid loss of active sites. Here, we present an inter-do... |
41540614 | [N⋯Br⋯N]<sup>+</sup> Type Halogen Bonding: From Structure to Applications. | Noncovalent halogen bonding, particularly the three-center four-electron (3c-4e<sup>-</sup>) [N⋯X⋯N]<sup>+</sup> motif, represents a critical tool in supramolecular chemistry and materials science. While I<sup>+</sup>-based systems are well-studied, this review focuses on the emerging and highly functional [N⋯Br⋯N]<sup... |
41540607 | Photo- and Copper Dual-Catalyzed <i>Z</i>-Selective Chlorosulfonylation of Allenes for Tetrasubstituted Alkenes. | The selectivity control of C═C double bonds, especially in tetrasubstituted olefins, is a fundamental issue due to their importance in organic chemistry, medicinal chemistry, and material chemistry. Herein, we observed that the stereoselectivity of chlorosulfonylation of allenoic acids or allenoates was reversed by app... |
41540604 | Programmable DNA Nanosprings with Tunable Chirality. | Helical chiral structures are prevalent in nature and play vital roles in both biological and engineering systems. However, precise control over these structures at the nanoscale remains a significant challenge. In this study, we propose a general design strategy for helical chiral DNA structures, facilitating the bott... |
41540426 | Pathogen-specific IgE-reactive cytosolic allergenic epitopes of Aspergillus fumigatus for immunodiagnostic/immunotherapeutic applications against allergic aspergillosis. | Aspergillus fumigatus is a significant fungal pathogen responsible for allergic bronchopulmonary aspergillosis (ABPA), a global respiratory disease characterized by high morbidity and mortality. Accurate diagnosis of ABPA remains challenging due to the overlap of clinical and radiological features with other respirator... |
41540378 | Smart patches for healthcare industry: a review of emerging technologies, challenges, and developmental opportunities. | <h4>Background</h4>Smart patch healthcare devices are emerging as a distinct user interface in decoding the bidirectional interaction of the five sense organs. Powered by recent advancements in nano-materials, and artificial intelligence predictions, smart patches could understand the immune response of the body by ana... |
41540297 | Novel Cocrystal of Quercetagetin: In vitro and in vivo Insights into Biopharmaceutical Performance. | <h4>Purpose</h4>Quercetagetin (QTGN) is a naturally occurring flavonol predominantly sourced from marigold flowers and possesses notable therapeutic potential, including antidiabetic, anticancer, antioxidant, anti-inflammatory, and antiviral properties. However, poor aqueous solubility and in turn bioavailability restr... |
41540295 | Forecasting the Biological Effect of PEGylated-rHuEPO Candidates in Chronic Kidney Disease Patients using a Middle-out Translation Approach. | <h4>Background</h4>Anemia is a common and debilitating complication in patients with chronic kidney disease (CKD), often managed with erythropoiesis-stimulating agents. While PEGylation extends drug half-life, it may alter pharmacodynamics, requiring careful dose optimization. This study applies a middle-out translatio... |
41540249 | Controlled spherulitic crystal growth from salt mixtures. | Spherulites are spherical crystals that are polycrystalline assemblies of radially organized crystallites. Despite their wide prevalence and relevance to fields ranging from geology to medicine, the dynamics of spherulitic crystallization and the conditions required for such growth remain ill-understood. Here, we revea... |
41540050 | Early retinal synaptic dysfunction and proteomic remodeling precede neurodegeneration in a Parkinson's disease model. | Parkinson's disease (PD) affects motor and non-motor systems; however, retinal changes and their molecular basis are not well understood. Using a transgenic mouse model overexpressing A53T-mutant human α-synuclein, we examined retinal function, structure, and proteomics at 6- and 16 months. Early retinal dysfunction wa... |
41540042 | Thiazole-conjugated covalent organic framework membranes enable ultraselective molecular desalination under strongly acidic conditions. | Membrane nanofiltration provides a sustainable and energy-efficient platform for precise molecular separation. However, highly permselective and chemically stable membrane materials capable of operating under harsh conditions are currently lacking. Here we report a generalizable monomer-solvent dual engineering strateg... |
41540018 | Near-infrared-driven photocatalytic CO<sub>2</sub> reduction to C<sub>2</sub> hydrocarbons by bis(terpyridine)-metal functionalized lead halide frameworks. | Hybrid lead halides have demonstrated great promise for CO<sub>2</sub> photoreduction due to their excellent photophysical properties. However, developing a single-component hybrid lead halide that combines high intrinsic stability with near-infrared absorption remains a significant challenge. Herein, to address both i... |
41540012 | HEXIM1 inter-monomer autoinhibition governs 7SK RNA binding specificity and P-TEFb inactivation. | Hexim proteins are key RNA-dependent regulators of eukaryotic transcription through 7SK-dependent sequestration and inactivation of the kinase P-TEFb (Cdk9-CyclinT1/2) in the 7SK RNP. P-TEFb activity drives release of RNA polymerase II from promoter-proximal pausing for eukaryotic and HIV-1 transcription. The molecular... |
41540004 | Mixed-model and transcriptome-wide association analyses identify transcription factors and genes associated with colorectal cancer susceptibility. | Susceptibility transcription factors (TF) whose DNA bindings are altered by genetic variants regulating colorectal cancer (CRC) risk genes remain poorly defined. Using generalized linear mixed models, we analyze 218 TF ChIP-Seq datasets alongside GWAS data from 100,204 CRC cases and 154,587 controls of East Asian and E... |
41540001 | A high-throughput, flow cytometry approach to measure phase behavior and exchange in biomolecular condensates. | Biomolecular condensates are essential for cellular organization, yet their formation dynamics and molecular content exchange properties remain poorly understood. Here we show that flow cytometry provides a high-throughput, solution-based platform for analyzing condensate behavior at the single-droplet level. Using sel... |
41539976 | Nanoparticle-Single-Atom Tandem Catalyst within a Metal-Organic Framework for Efficient Ethylene Electrosynthesis. | Copper nanoparticles (Cu NPs) are effective catalysts for the electroreduction of CO<sub>2</sub> (ECO<sub>2</sub>R) to multicarbon products but suffer from insufficient selectivity, aggregation, and deactivation. To address these challenges, we developed an in situ encapsulation strategy that engineers Cu NPs in a meta... |
41540011 | Targeting sorting nexin 3 to treat pulmonary fibrosis by dual modulating Wnt/β-catenin signaling. | Pulmonary fibrosis (PF) is a chronic progressive lung disorder characterized by overactivation of Wnt/β-catenin signaling and limited therapeutic efficacy. This study identifies sorting nexin 3 (SNX3), a retromer-associated protein, as a dual regulator of PF pathogenesis through coordinated molecular mechanisms. SNX3 i... |
41538731 | Molecular Microheterogeneity: Structure Formation in Amine-Water Mixtures. | Aqueous alkylamine mixtures reveal an unexpected form of molecular self-assembly analogous to more complex soft matter systems. Using X-ray scattering, we uncover exceptionally intense structural prepeaks, sometimes surpassing the first sharp diffraction peak, which indicate stable microheterogeneity over nanometer sca... |
41538721 | Miniature Photo-Driven Microbubble Capture Actuator Based on Optical Fiber Microcavity. | Micronano capture systems capable of efficiently trapping target particles have been a focus in biomedical engineering, lab-on-a-chip devices, and targeted drug delivery. Here, we propose a miniature photodriven microbubble capture actuator based on an optical fiber microcavity. The actuator consists of an optical fibe... |
41538719 | Mechanistic Studies of the Calcium-Dependent Antibiotics via Cofactor Engineering. | The defining feature of calcium-dependent antibiotics (CDAs) is that they require the presence of calcium cation (Ca(II)) as a cofactor to exert antibacterial activity. We recently showed that substituting two key aspartic acids (Asp) with serine (Ser) in laspartomycin C (LspC) converts it from a CDA into a boron-depen... |
41538715 | Stabilization of Fully Deprotonated Melaminate Anions (C<sub>3</sub>N<sub>6</sub>)<sup>6-</sup> in M<sub>3</sub>(C<sub>3</sub>N<sub>6</sub>) (M = Cd, Ca). | Hydrogen-free melaminate salts M<sub>3</sub>(C<sub>3</sub>N<sub>6</sub>) (M = Cd, Ca) were synthesized in laser-heated diamond anvil cells at 34-48 GPa and 2000-2500 K. Cd<sub>3</sub>(C<sub>3</sub>N<sub>6</sub>) was synthesized via a direct reaction between the elements, while Ca<sub>3</sub>(C<sub>3</sub>N<sub>6</sub>)... |
41538649 | Meso-Crowned Porphyrin as a Dual Cavity Hybrid Macrocycle for Improving the Efficiency and Stability of Perovskite Solar Cells. | Perovskite solar cells (PSCs) have achieved remarkable power conversion efficiencies (PCEs) and cost-effective fabrication processes. However, defects in the bulk and interfaces of perovskite materials, as well as Li<sup>+</sup> migration (especially in n-i-p regular architecture), which are used to enhance the conduct... |
41538550 | Polyhedral Oligomeric Silsesquioxane-Based Ionic Liquids: Syntheses, Properties, and Applications. | Polyhedral oligomeric silsesquioxanes (POSS) and ionic liquids (ILs) have emerged as highly promising components for the design of advanced hybrid materials. The integration of ILs onto the POSS core has led to the development of a novel class of materials known as POSS-based ILs (POSS-ILs), which synergistically combi... |
41538468 | Near-Infrared Cocrystal Nanofluorophore with Enhanced Two-Photon Absorption Cross Sections. | The growing demand for organic nanoprobes that combine broadband two-photon absorption (TPA) with near-infrared (NIR) optical excitation continues to drive advancements in biological imaging and advanced photonics. However, the design and preparation of such nanoprobe materials remain a significant challenge. Here, we ... |
41538406 | A Golden Fullerene Encapsulating Schmid Gold. | Since its first synthesis in 1981, determining the structure of the "Schmid gold"─initially determined as a Au<sub>55</sub>(PPh<sub>3</sub>)<sub>12</sub>Cl<sub>6</sub> cluster─has remained a big challenge. In this study, fluorine chemistry is exploited to stabilize the largest structurally resolved gold nanocluster sta... |
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