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41544744 | MOF-derived AgCl/ZnO heterojunction photocatalysts: Enhanced degradation of tetracycline via promoted charge carrier separation. | With the widespread application of tetracycline (TC) in pharmaceuticals and aquaculture, the ecological and health risks caused by its residues have become increasingly prominent. The construction of heterojunction systems exhibiting high-efficiency carrier separation has emerged as a highly promising approach for the ... |
41544587 | Highly efficient heavy metal remediation from multiple scenarios actual industrial wastewaters by ultralong sub-5 nm polyoxometalate ionic liquid fibrilization strategy. | Reducing heavy metals to trace levels in actual complex industrial wastewater remains a major challenge due to high salinity, organic interferences, and multi-metal competition. Ionic liquids (ILs) are promising for metal remediation but suffer from limited active site accessibility and slow diffusion in conventional i... |
41542345 | Hyaluronan like polysaccharide based nanodrugs with enhanced CD44 avidity for image-guided drug delivery to breast cancer. | Targeted drug delivery is an exciting strategy to treat cancer and reduce the harmful side effects of chemotherapy to normal tissues. CD44 has been an attractive target for drug delivery due to its expression on many types of tumor cells including breast cancer. To better target the CD44-expressing breast cancer cells,... |
41542340 | Biocatalyzed aza-michael addition <i>via</i> continuous flow technology: a game-changer for the facile synthesis of <i>N-</i>alkylated pyrazole derivatives. | <i>N</i>-Alkylated pyrazole derivatives are widely used in the treatment of prostate cancer, depression, epilepsy and sickle cell disease due to their remarkable anti-tumor, anti-depressant and anti-bacterial activity. In this work, a convenient synthesis of <i>N-</i>alkylated pyrazole derivatives from pyrazoles and α,... |
41541217 | Novel amide-based macrocyclic Co(ii) complexes: correlating structural, computational, and biological properties through DFT and docking. | A series of Co(ii) complexes incorporating functionalized macrocyclic scaffolds, designated as [Co(N<sub>4</sub>O<sub>4</sub>MacL<sub>1</sub>)Cl<sub>2</sub>]-[Co(N<sub>4</sub>O<sub>4</sub>MacL<sub>3</sub>)Cl<sub>2</sub>], were synthesized using three structurally related macrocyclic ligands (N<sub>4</sub>O<sub>4</sub>M... |
41541208 | Functionalized graphene quantum dots based non-enzymatic sensor for selective tyrosine detection. | Tyrosinemia is an inherited metabolic disorder that occurs due to the disruption in the breakdown of the amino acid 'tyrosine'. Elevated levels of tyrosine cause liver failure, and neurological damage in newborns. Hence, rapid and accurate detection of tyrosine is essential for the timely management and diagnosis of th... |
41541207 | Design, synthesis, and biological evaluation of novel chalcone derivatives: integrating molecular docking with <i>in vivo</i> anti-inflammatory and antinociceptive studies. | Chronic inflammatory disorders are often accompanied by persistent pain, yet current therapies remain limited by modest efficacy and adverse effects. To address this challenge, a series of eleven chalcone-based derivatives was synthesized <i>via</i> Claisen-Schmidt condensation and structurally characterized by FTIR, <... |
41541201 | Zr-gallic acid based metal organic compound as adsorbent for extraction of uranium(vi) from nitrate solution: adsorption behaviors and mechanisms. | In this study, a zirconium-gallic acid metal-organic compound (Zr-GA) was synthesized <i>via</i> a hydrothermal method and evaluated as a high-performance adsorbent for uranium(vi) removal from aqueous solutions. Comprehensive physicochemical characterization confirmed the formation of a mesoporous sorbent with a highl... |
41535729 | Tuning the Liquid-Liquid Phase Separation of FUS by Phosphorylation: A Role of Domain-Specific Compensation. | Biomolecular condensates, a type of subcellular or membraneless organelle, form through liquid-liquid phase separation (LLPS) driven by multivalent interactions. As an RNA-binding protein, FUS participates in biological processes by forming dynamic liquid condensates via LLPS, with its abnormal fibrous aggregation asso... |
41535595 | Molecular driving force of a small molecule-induced protein disorder-order transition. | The selectivity and affinity of numerous protein-protein interactions depends upon the folding of intrinsically disordered regions (IDRs) that accompanies complexation. Here we investigate how folding-on-binding of a protein IDR by small molecules is facilitated by synergestic exploitation of interactions with a folded... |
41535510 | Targeted immunotherapies and nanomedicines for ovarian cancer: the way forward. | Ovarian cancer (OC) is the leading cause of death among gynecological cancers, with high mortality due to late diagnosis. Immunotherapy and nanomedicine show potential in targeting cancer cells and inducing immunogenic cell death. However, challenges like poor biodegradability and untargeted immune activation persist. ... |
41535415 | Revealing and characterizing bacterial communities of in vitro Musa species through 16S rDNA metabarcoding and culture dependent approaches. | Bananas and plantains, part of the Musa genus, are key global food crops that are threatened by various factors, including hurricanes and microbial infections. The production of phytopathogen-free plants in Temporary Immersion Bioreactors (TIB) has gained attention due to improved yield and health. However, the impact ... |
41535385 | The gene-modulating power of Tannins isolated from Jatropha integerrima flowers on the transcriptomic profile of multidrug-resistant Klebsiella pneumoniae. | The continuous increase in antibiotic resistance necessitates a global need to search for new sustainable antimicrobial agents, such as plant-delivered antimicrobial components. This study investigates the antimicrobial and antibiofilm properties of two tannins isolated from the flowers of Jatropha integerrima against ... |
41535298 | Antigravity confined interfacial self-assembly approach for the synthesis and characterization of nanofilms. | Gravitationally induced stratification during self-assembly often leads to density-driven vertical segregation, resulting in an inherent density gradient that severely limits the synthesis of metastable nanofilms requiring inverted architectures. Here we show an antigravity confined interfacial self-assembly approach b... |
41534901 | Trispecific targeting of T cells engineered with TCR mimic antibodies to limit antigen escape. | <h4>Background</h4>Antigen loss and tumor heterogeneity present significant challenges for successful immunotherapies. T-cell receptor (TCR)-based therapies rely on the recognition of epitopes derived from intracellular tumor proteins presented by major histocompatibility complex class I molecules on cell surface. Soli... |
41534876 | Rehmannins A-D, Anti-inflammatory Carotenoid Pigments from the Fresh Root of <i>Rehmannia glutinosa</i>. | Four novel carotenoid derivatives, rehmannins A-D (<b>1</b>-<b>4</b>), were isolated from the fresh roots of the traditional Chinese medicinal plant <i>Rehmannia glutinosa</i>. The structures of these new compounds were determined by extensive spectroscopic methods (high-resolution mass spectrometry, NMR, and electroni... |
41534079 | Biocatalytic Nanoregulators Restore Joint Redox-Immune Homeostasis in Rheumatoid Arthritis. | Rheumatoid arthritis (RA), a debilitating autoimmune disorder marked by progressive synovitis and osteochondral erosion, presents critical therapeutic challenges due to the limitations of existing regimens, including non-specific biodistribution and compromised risk-benefit profiles. In this study, a novel therapeutic ... |
41534040 | Copper and Silver Cuboctahedron Cavities in Halide Encapsulation: Evaluation of Interaction Energy and Optical Properties Given by the Inclusion of Halides as Non-Innocent Templates. | The formation of anion-templated molecular clusters offers the encapsulation of different anions, enabling further understanding of the interaction between the inner anion and the resulting metal cavity. Here, we evaluated two prototypical isostructural copper and silver clusters with a halide anion embedded into a cub... |
41533965 | Pore Environment Engineering in Al-MOFs Enables Thermodynamic-Kinetic Synergy for High-Resolution Chromatographic Separation. | Aluminum-based metal-organic frameworks (Al-MOFs) are recognized as promising materials for chromatographic separation, but achieving an optimal thermodynamic-kinetic balance for the separation of aromatic isomers remains challenging. Herein, we demonstrated a ligand functionalization strategy to tune the pore environm... |
41533891 | Prediction of Protein-Ligand Binding Affinities Using Atomic Surface Site Interaction Points. | Atom surface site Interaction Points (AIP) which were previously used to predict association constants for synthetic host-guest systems has been extended to protein-ligand complexes. AIP descriptions of protein binding sites were obtained by combining a library of precomputed AIP descriptors for all protein functional ... |
41533889 | Confining Macrocyclic Molecules into a Porous Metal-Organic Framework for Enhanced Proton Conduction. | Given the critical need for high-performance proton-exchange materials in clean energy devices, design and synthesis of composite materials based on metal-organic frameworks (MOFs) has emerged as a highly promising strategy due to their unique porosities, tunable functionalities, and high surface areas. Herein, functio... |
41533798 | Lipid self-assembly dependence on hyaluronic acid size reveals biolubrication and osteoarthritic degeneration mechanisms. | Hyaluronic acid (HA) and phospholipids (PLs) are key components of joint lubrication. In osteoarthritis (OA), the molecular weight (MW) of HA is reduced, which has been proposed to weaken the anchoring capacity of PL and impair lubrication. This study reveals a different mechanism by directly linking the MW to the stru... |
41533796 | Revitalizing poly(urea)s via disulfide reconfiguration. | Weak bonds are well-known to construct soft materials. Elaborating molecule-level self-assembly via supramolecular engineering could generate performance materials that exhibit high strength at mild temperatures. However, the entropy penalty of assembled materials, meanwhile, compromises robustness at elevated temperat... |
41533788 | Inflammation-triggered self-immolative conjugates enable oral peptide delivery by overcoming gastrointestinal barriers. | Oral delivery of peptide therapeutics remains challenging due to gastrointestinal (GI) degradation and poor intestinal absorption. Here, we propose a self-immolative peptide prodrug conjugate (SIPPC) platform for inflammation-targeted oral delivery, integrating a hydrophilic polyethylene glycol segment, a reactive oxyg... |
41533740 | Transcriptomic and ultrastructural responses to Amiodarone-Itraconazole in naturally benznidazole-resistant and -susceptible Trypanosoma cruzi strains. | Chagas disease (CD), caused by Trypanosoma cruzi, remains a major therapeutic challenge, primarily due to the limited efficacy of benznidazole and the emergence of naturally resistant strains. In this context, drug repurposing offers a promising strategy to identify compounds with trypanocidal activity. In this study, ... |
41533527 | Catechol-Type Porphyrin-Based Bimetallic MOF for High-Capacity Lithium-Ion Storage. | Metal-organic frameworks (MOFs) have attracted considerable attention in the field of energy storage due to their ordered porosity, robust frameworks, and rapid ion diffusion channels. However, most of the original MOFs exhibit poor reaction kinetics and chemical stability when used as anode materials in lithium-ion ba... |
41533499 | Supramolecular Metallacycle Enables Esterase-Responsive and Endoplasmic Reticulum-Associated Pathway Activation for Synergistic Photothermal Immunotherapy. | Supramolecular metallacycles present a unique platform for integrating therapeutic modalities; yet, their application for activating the cGAS-STING pathway remains to be explored. Herein, we report an endoplasmic reticulum (ER)-accumulated supramolecular Pt(II) metallacycle (<b>M2</b>) that enables esterase-responsive ... |
41533493 | Solid-State Synthesis, X-ray Structure, and Guest Inclusion in Octahedral <b>M<sub>6</sub>L<sub>4</sub></b> Cages Self-Assembled by Tris-pyridyl-benzene (<b>TPB</b>). | The challenges found to self-assemble crystalline octahedral <b>M</b><sub><b>6</b></sub><b>L</b><sub><b>4</b></sub> metal-organic cages (<b>MOCs</b>) with the tridentate 2,4,6-tris(4-pyridyl)benzene (<b>TPB</b>) ligand and Pd<sup>2+</sup> are due to the dihedral angle θ ∼ 36° between the pyridines and the central benze... |
41536150 | Utilizing Flux to Inform Formulation Strategy Decisions in Preclinical Studies. | In preclinical settings, flux experiments can serve multiple purposes, such as (1) to select a formulation that provides higher flux, (2) to establish use-times for supersaturating formulations such as spray dried dispersion suspensions, and (3) to explain variation in exposures in in vivo experiments. In the current m... |
41535879 | Investigating the impact of gut microbiota-derived metabolites on benign prostatic hyperplasia using network pharmacology approaches. | <h4>Background</h4>The gut microecosystem represents the most abundant and complex microbial ecosystem in the human body. Maintaining homeostasis of gut microbiota and their metabolites is essential for human health. As a chronic metabolic disorder, the association between benign prostatic hyperplasia (BPH) and gut mic... |
41533298 | β-Cyclodextrin-Functionalized Sodium Alginate Nanocarrier Co-Loaded with Naringenin Attenuates Pregnancy-Induced Hypertension Via JAK/STAT3 Pathway Inhibition. | Pregnancy-induced hypertension (PIH) is a condition marked by elevated blood pressure during pregnancy, posing serious risks to both maternal and perinatal health, including increased mortality. Due to the safety concerns and side effects of current treatments for PIH, the search for new therapeutic agents is urgently ... |
41532964 | Photocatalytic Biohybrid Vesicles. | Semiartificial photosynthesis presents an attractive route to overcome limitations of natural photosynthesis for sustainable chemicals production. Synthetic materials are combined with biological molecules, forming biohybrid systems, that provide unique opportunities to innovate new solar-to-chemical pathways. There ar... |
41532874 | One-Shot SERRS Detection of Iron and Acidity in Aqueous Systems. | Optical strategies for ion sensing hold promise for portable and in situ analysis, yet their reliability is frequently limited by pH-dependent interferences that alter metal-ligand interactions. Herein, we present a multiprobe surface-enhanced resonance Raman scattering (SERRS) platform that enables simultaneous quanti... |
41532802 | Background-Free Nanopore Decoding of microRNA Expression Patterns Using Circular Diagnostic DNA. | This paper describes a background-free nanopore decoding method to identify microRNA (miRNA) expression patterns that are both upregulated and downregulated. This method uses a circular DNA construct on MinION, a commercially available nanopore device. This system uses a pair of complementary diagnostic DNAs (dgDNAs) t... |
41532794 | Modulating Supramolecular Topology via Hydrogen Bonding in a Eumelanin Monomer. | Eumelanin is a bio-pigment with remarkable photoprotective properties, whose function is tied to its complex supramolecular organization. Although hydrogen bonding and π-π interactions are recognized as key forces in shaping its architecture, their individual contributions remain poorly defined. Among its molecular pre... |
41532771 | Protective mechanism of action of the antifungal drug naftifine against <i>Mycobacterium abscessus</i> infection. | <i>Mycobacterium abscessus,</i> a rapidly growing nontuberculous mycobacterium, causes chronic pulmonary infections that are difficult to treat due to extensive intrinsic drug resistance. Through high-content screening of 786 FDA-approved drugs against intracellular <i>M. abscessus</i> in human THP-1 macrophages, we id... |
41532763 | Coordination Complexes and Polymers of Novel Hybrid Tetrazole-Triazole-Pyrazole Ligands: Synthesis, Structural Characterization, and Biological Evaluation. | New series of triazole/pyrazole and tetrazole/triazole/pyrazole ligands were synthesized and coordinated with various transition metals to yield a diverse library of 14 complexes. All compounds were fully characterized by elemental analysis, mass spectrometry, powder X-ray diffractometry, and a range of spectroscopic t... |
41532769 | Characterization of a novel monoclonal antibody candidate that targets bacterial GAPDH and protects neonatal mice from infections caused by <i>Streptococcus pneumoniae</i> or <i>Streptococcus agalactiae</i>. | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a highly conserved bacterial enzyme essential for glycolysis, yet it also plays important non-metabolic, "moonlighting" roles, including host immunomodulation. Here, we describe the generation and characterization of a monoclonal antibody (mAb01) that targets extracel... |
41532757 | Key residues in SARS-CoV-2 NSP3 hypervariable region are necessary to modulate early stress granule activity. | Antagonism of the host responses that limits viral replication is critical to the success of infection. Recently, we identified that the hypervariable region (HVR) of SARS-CoV-2 NSP3 binds to FXR1 and disrupts stress granule formation during the early stages of infection. Despite variation across the rest of the HVR, a... |
41532728 | Single-atom Electronic Bridge Facilitates Cascade Electron Transfer From Encapsulated Polyoxometalate to Metal-Organic Framework for Efficient Photocatalytic CO<sub>2</sub> Conversion. | The POM@MOF system, integrating the exceptional properties of polyoxometalates (POM) and metal-organic frameworks (MOF), exhibits considerable catalytic potential. However, the absence of stable and well-defined electron-transfer pathways between the two components hampers charge separation and transport, thereby limit... |
41532685 | Beyond Traditional RAFT Polymerization: Emerging Strategies and Future Perspectives; A Third Update. | Reversible addition-fragmentation chain transfer (RAFT) polymerization has undergone transformative growth since its inception in 1998, emerging as a powerful and versatile tool for precision polymer synthesis. This review highlights the latest developments in non-traditional RAFT polymerization from 2020 to 2025, capt... |
41532694 | Selenium-Based Molecular Cage Crystal β-P<sub>4</sub>Se<sub>3</sub>Br<sub>2</sub>: A Promising Candidate for Infrared Nonlinear Optical Applications. | Nonlinear optical (NLO) crystals play a vital role in a wide range of applications including all-solid-state lasers and infrared (IR) NLO devices. However, existing commercially available IR NLO crystals, such as AgGaS<sub>2</sub> (AGS), AgGaSe<sub>2</sub> (AGSe), and ZnGeP<sub>2</sub> (ZGP), face limitations due to lo... |
41532680 | Poly(ethylene glycol) Crystallization in Multifunctional Polypeptide-Polymer Hybrids Based on Human Serum Albumin Scaffolds. | We employ cationized human serum albumin as a scaffold for attaching poly(ethylene glycol) (PEG) chains at precise locations along the protein backbone. Subsequent denaturation unfolds the protein backbone, resulting in brush polymers with a well-defined, monodisperse, polypeptide backbone with PEG side chains. The def... |
41532668 | Halogen-Bond Coupled Halogenated-π-Conjugation Enables Giant Birefringence in Hydrogen-Bonded Organic Frameworks. | Birefringent crystals are essential optical materials for modulating and detecting the polarization state of light. However, achieving large optical anisotropy remains a significant challenge, mainly because it is difficult to rationally align anisotropic fundamental building blocks (FBBs) to maximize their collective ... |
41532664 | Host-Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules. | The increasing prevalence of emerging infectious diseases highlights the urgent need for broad-spectrum antiviral therapeutics. Here, the discovery of SB2960, a small molecule, is reported that promotes stress granule (SG) formation and exhibits potent antiviral activity across diverse viral species. SB2960 suppresses ... |
41532653 | Reaction Mechanism, Challenges, and Strategies of High-Energy-Density Sodium-Ion Batteries. | Sodium-ion batteries (SIBs) have attracted considerable research interest for large-scale energy storage due to the natural abundance and wide geographic distribution of sodium. Among various cathode materials, conversion-type cathodes have garnered particular attention due to their element richness, high specific capa... |
41532591 | A Dual-Receptor System Mediates <i>p</i>-Coumaric Acid Sensing/Degradation for Enhanced Bacterial Virulence. | Plants deploy diverse secondary metabolites for chemical defense against pathogens, and in response, phytopathogens have evolved elaborate counterstrategies to subvert host immunity. In this study, we demonstrate that <i>Pseudomonas syringae</i> pv <i>actinidiae</i> strain M228 (<i>Psa</i>_M228)─the causal agent of kiw... |
41532502 | A Mini-Spidroin Forms High-Performance Artificial Spider Silk via Edge-Cysteine-Locked β-Sheet Assembly. | Spider silk's remarkable mechanical properties arise from its hierarchical organization, where β-sheet nanocrystals confer strength and amorphous chains impart extensibility. However, replicating this performance in synthetic fibers has been hindered by the challenges of expressing high-molecular-weight spidroins and p... |
41532497 | Microenvironment Self-Adaptive Nanoarmor to Address Adhesion- and Colonization-Related Obstacles in Impaired Intestine Promote Bacteriotherapy Against Parkinson's Disease. | Intestinal localized inflammations are recognized as key contributors to the incidence and progression of diverse extraintestinal disorders. Probiotic colonization has been increasingly highlighted for its potential to modulate susceptibility and progression of such diseases. Considering the adhesion- and colonization-... |
41532471 | In vitro affinity maturation of a single-chain antibody against thyroxine based on computer-aided design. | Thyroxine (T4) plays a crucial role in regulating various physiological functions in the human body. As a key biomolecule for molecular recognition, single-chain variable fragments (scFvs) offer advantages, such as small molecular size, high specificity, and strong affinity, making them ideal alternatives to traditiona... |
41532357 | Regulating the Transfer of Photogenerated Carriers on CdS Nanorods by Conductive Bimetallic CuNi-MOF for Highly Selective Photocatalytic Benzylamine Oxidation Integrated with H<sub>2</sub> Production. | The simultaneous utilization of photoelectrons and holes to achieve the coupling of photocatalytic hydrogen evolution with the selective oxidation of organic substances holds significant importance. Yet, this strategy is often constrained by the inadequate charge separation efficiency of photocatalysts and the scarcity... |
41532352 | High-Strength and Reprocessable Supramolecular Polydiketoenamine Network Materials for Sustainable Adhesives. | Achieving both high strength and reprocessability in a single plastics material remains a fundamental challenge. Herein, we report the design and synthesis of novel supramolecular polydiketoenamine (PDK) network materials that were synergistically dual crosslinked by both the dynamic diketoenamine bonds and supramolecu... |
41532306 | Carbon Dot-Based Mechanofluorescent Hydrogel with Tunable Fluorescence for Bioengineering Applications. | Fluorescent hydrogels are emerging as versatile platforms for tissue engineering and soft robotics due to their ability to transduce mechanical stimuli into optical signals. However, existing systems respond only to large stresses, suffer from fluorescence quenching, and lack bioactive functionalities, limiting their a... |
41532312 | Cooperative Rotation of Multiple F<sub>o</sub>F<sub>1</sub>-ATPase Motors in a Janus Photophosphorylation Nanobot. | Inspired by the precise collective action of biological motors, we here develop asymmetric photophosphorylation nanobots through the hierarchical co-assembly of thylakoid vesicles and lecithin liposomes. This approach yields anisotropic vesicles that preserve robust photophosphorylation capacity activity while integrat... |
41532286 | Synthesis of Highly Luminescent Chiral Macrocyclic Molecular Carbon Imides. | We report the synthesis of racemic macrocyclic molecular carbon imides, <b>(±)-C[2]BNDI</b> and <b>(±)-C[3]BNDI</b>, using 1,1'-bi(naphthyl-4,5-dicarboximides) (<b>BNDI</b>) as a building block. Single-crystal analysis revealed a twisted saddle-shaped π-framework for <b>(±)-C[2]BNDI</b>. Both macrocycles exhibit strong... |
41532248 | Tailoring Nano-Metal-Organic Frameworks and Their Derivatives: From Morphology Engineering to Structural and Functional Optimization. | Rational synthesis of nano-metal-organic frameworks (nano-MOFs) and their derivatives is crucial for tailoring structural and functional properties toward meet the demands of advanced energy applications. This review systematically categorizes synthesis strategies into precursor structure engineering and conversion eng... |
41532164 | Multifunctional Copper Ion-Mediated Carrier-Free Scutellarin Hydrogel for Diabetic Wound Healing. | Chronic diabetic wounds suffer from persistent inflammation, oxidative stress, and impaired angiogenesis. This study develops a carrier-free Cu-SCU hydrogel via self-assembly of scutellarin (SCU) and copper ions (Cu<sup>2</sup>⁺), without polymers or excipients. Spectroscopic analyses and molecular dynamics simulation ... |
41531232 | Improved Messenger RNA Stability and Biocompatibility Through Self-Gelatinizable Nucleic Acids. | Recent advances in the chemical synthesis and modification of messenger RNA (mRNA) have generated growing interest in mRNA-based therapeutics. However, the inherent instability of mRNA in vivo and during storage remains a major challenge, requiring the development of safe and effective delivery systems. Lipid nanoparti... |
41531233 | An AlFu MOF nanoadjuvant functionalized with mannose for potential dendritic-cell targeting and dual TLR9-STING activation. | <h4>Background</h4>Aluminum adjuvants remain the most widely used adjuvants in licensed vaccines. Their broader application, however, is restricted by local and systemic adverse effects and limited antigen compatibility, slowing vaccine development.<h4>Methods</h4>A nanoscale aluminum - fumarate metal - organic framewo... |
41530843 | Discovery and design of novel glucoamylases suitable for raw starch hydrolysis at moderate temperatures via an integrated bioinformatics-assisted strategy. | Glucoamylases capable of hydrolyzing raw starch at moderate temperatures exhibit significant potential for the direct and efficient hydrolysis of raw starch. Using bioinformatics-assisted mining strategies, four candidate glucoamylases were initially identified from the GenBank database. Among these candidates, SeGA de... |
41530118 | Acute pancreatitis: mechanisms and therapeutic approaches. | Acute pancreatitis is a complex inflammatory condition characterized by sudden onset and rapid progression, with severe cases often associated with high mortality. In recent years, the global incidence of acute pancreatitis has been increasing, with marked regional differences. This increasing trend not only places a c... |
41530122 | Data-driven visualization of silica-based nanobiomaterial dynamics for tissue regeneration. | Over the past two decades, silica-based nanobiomaterials (SNs) have emerged as a promising frontier in regenerative medicine, garnering substantial interest for their potential applications. Despite this growing interest, a notable lack of comprehensive and dynamic analyses remains, examining the evolution, development... |
41439433 | Evaluating the strength of molecular interactions in a deep eutectic solvent (DES) by means of ionization mechanisms involved in cold-spray ionization mass spectrometry and by DFT calculations. | This paper regroups the results of mass spectrometry analysis of two categories of deep eutectic solvents (DESs) using electrospray (ESI) and cold-spray (CSI) ionizations. Mass spectrometry of octanoic based DES's is first presented by proposing an interpretation of the ESI and CSI mass spectra based on the knowledge o... |
41410320 | Supramolecular self-assemblies of Ru(II) phototherapeutics: biological activity of micro- and nano-particles acting as reservoirs. | Ruthenium(II) coordination complexes have many appealing properties as prodrugs, but can suffer from poor aqueous solubility and short circulation times, drastically decreasing efficiency <i>in vivo</i>. Nanoformulations using a variety of carriers, such as inclusion in polymers/lipids or adsorption on inorganic nanopa... |
41404694 | Hydrogenation of ethylene over molybdenum-sulfur complexes supported on UiO-66. | Development of supported single-site catalysts using small metal sulfide complexes could significantly help in the development of cost-effective catalytic materials to drive selective hydrogenation and hydrogenolysis. The goal of this study is to contribute to the development of metal sulfide catalysts by calculating t... |
41400011 | Ultra-high multiplex PCR uniformity is enhanced by carbon nanotube-dendrimer-encapsulated gold nanoparticles. | Polymerase chain reaction (PCR) remains the gold standard in molecular diagnostics. However, under highly multiplexed conditions, PCR often suffers from poor amplification uniformity, which limits its high-throughput potential and clinical applicability. To address this limitation, we developed a novel nanocomposite-ca... |
41395779 | Macromolecular dimensions of a synthetic polyelectrolyte as a factor in its interactions with protein and cells: desirability for longer chains. | Understanding the mechanism of interactions between synthetic polyelectrolytes and ionic matter, which are ubiquitous in living systems, such as proteins and cells, is a fundamental challenge and an important requirement for their clinical development as biomaterials and drug delivery systems. In contrast to small mole... |
41384948 | A gallium-integrated nanoplatform for synergistic therapy of <i>Pseudomonas aeruginosa</i> wound infections. | With the growing threat of antimicrobial resistance, novel antibacterial strategies are required for the treatment of bacterial infections. Herein, we constructed a gallium-integrated metal-organic framework nanoplatform (denoted as GaLPCN) to achieve synergistic photodynamic and iron-interference therapy of <i>P. aeru... |
41384341 | Rhodium(II)-incorporated metal-organic framework catalyst combined with flow chemistry for efficient carbene-mediated three-component reactions. | We integrate a recyclable Rh-MOF heterogeneous catalyst into carbene-mediated three-component reactions of diazo compounds, alcohols and electrophiles. This system exhibits broad functional group tolerance, excellent diastereoselectivity, and high turnover number (TON = 856), while enabling continuous-flow gram-scale s... |
41383172 | Green synthesis of α-aminophosphonates: from hydrogen-bonded Janus dimers to pharmaceutical potential. | A family of α-aminophosphonates, dimethyl (A), dipropyl (B), and diisopropyl (C), was synthesized through a green, catalyst-free Kabachnik-Fields reaction and characterized using FT-IR, NMR, and UV-Vis spectroscopy, single-crystal X-ray diffraction, DFT calculations, and multiscale physicochemical analyses. All compoun... |
41369930 | Designed coiled-coil peptide nanoparticles with tunable self-assembly: distinct ordered nanostructures <i>via</i> nonnatural side chain modification and electrostatic screening. | Peptide 'bundlemers' are homotetrameric coiled-coils that form discrete cylindrical nanoparticles in aqueous solution. The stability of the coiled-coil design enables selective modification of exterior residues to program interparticle interactions. We designed a single charge-type (SC) bundlemer, containing only posit... |
41363043 | Sulfonated, sulfated thioglycosides and multivalence in heparanase inhibition. | Heparan sulfate (HS) analogs are synthetic oligo- and polysaccharides designed to mimic or enhance several biological properties of native HS. Organic synthesized compounds are very useful tools for understanding the structure-activity relationships of many biological events. Unlike heterogeneous mixtures of tissue-iso... |
41363025 | Effective diabetic wound prohealing by supramolecular ROS-responsive hyaluronic acid hydrogels <i>via in situ</i> production of nitric oxide and oxygen. | The wound dressings currently in use have difficulties in addressing chronic inflammation and hypoxia for refractory diabetic wound prohealing. Aiming to regulate the inflammatory and hypoxic microenvironment in diabetic wounds, supramolecular reactive oxygen species (ROS)-responsive hyaluronic acid (HA) hydrogels were... |
41362994 | X-shaped π-conjugated fluorophores enable cooperative ion-pair recognition with multicolour emission. | An X-shaped π-conjugated molecule (X1) incorporating orthogonal cation- and anion-recognition sites, azacrown ethers and dimesitylborane units, respectively, was synthesised and compared with two linear analogues (L1 and L2). UV/Vis absorption and fluorescence titration experiments revealed that X1 undergoes stepwise b... |
41362919 | Integrated design and application of metal-organic frameworks in ferroptosis-mediated cancer therapy. | Cancer is the most malignant disease in the world, and there is an urgent need to explore new and efficient therapeutic approaches. Ferroptosis, a new form of cell death, is characterized by the accumulation of reactive oxygen species and lipid peroxide, which has broad application scenarios in antagonizing the resista... |
41940236 | Metallic nanoparticles: from biosynthesis to biomedical applications, current scenarios and prospects. | Metallic nanoparticles (MNPs) have attracted significant interest among researchers since the previous century owing to their vast potential applications in emerging fields such as nanotechnology, nano-optics, nanoengineering, nanoenergy, and biomedicine. The rapidly increasing demand for various MNPs has driven resear... |
41858586 | A Comprehensive Review of Vitamin C for Cancer Therapy: Anti-Tumor Mechanisms and Nano-Formulation Strategies. | The rapid advancements in nanotechnology have provided unprecedented opportunities for the clinical translation of vitamin C (VC) in cancer therapy. Although pharmacological doses of VC exhibit potent anti-tumor activities via multiple mechanisms-including selective pro-oxidative stress induction, metabolic inhibition,... |
41837221 | From Binary to Ternary Hydrogen-Bonded Solids with Anisotropic Thermal Expansion. | Thermal expansion (TE) describes the behavior of a solid material as it responds to a change in temperature. The behavior is affected by the components of the material, and the strength of the bonds used to construct it. For materials that are held together by strong covalent bonds, TE is often reduced as the dimension... |
41783505 | Framing Function: Metallophthalocyanine-Based Metal-Organic Frameworks as Multifunctional Materials for Electrified Devices. | Metallophthalocyanine-based metal-organic frameworks (MPc-based MOFs) have recently emerged as a class of two-dimensional (2D) materials with unique tunability for control over both structural properties and growing applications. MPc-based MOFs possess a unique set of structural characteristics due to the combination o... |
41755817 | Non-Conjugated Linear Polysiloxane with Cluster-Triggered Circularly Polarized Luminescence. | In this study, we introduce a system that is both nonconjugated and nonaromatic, specifically engineered to generate luminescence via cluster-triggered emission in its aggregated state. By integrating a chiral moiety, <i>N</i>-(<i>tert</i>-butoxycarbonyl)-cysteine methyl ester (cys) as a side group into a linear poly-(... |
41704782 | Proteomic profiling identifies prognostic signature for Krukenberg tumor of gastrointestinal origin. | Krukenberg tumor (KT) primarily originates from the stomach and colorectum, but reliable biomarkers for distinguishing KT from other tumors at the same sites and predicting ovarian metastasis remain lacking. Using pressure cycling technology (PCT) and data-independent acquisition (DIA) mass spectrometry, we analyzed 26... |
41694964 | Patterns, Clinical Management, and Short-Term Outcomes of Acute Limb Ischemia (ALI) Seen In In-Hospital and Out-of-Hospital Onset. | Background Acute limb ischemia (ALI) is a vascular emergency associated with high morbidity and mortality. While most studies focus on community-onset ALI, some patients develop ALI during hospitalization for other medical conditions, where outcomes and decision-making may differ. Data on the in-hospital onset ALI rema... |
41659835 | Synthon Substitution via C-I···π and C-I···N Halogen Bonds in Cocrystals of Anthracene-Based Organic Semiconductor Isosteres. | Cocrystallization is a versatile supramolecular synthetic strategy for tuning the properties of organic semiconductors (OSCs) and related polycyclic aromatic hydrocarbons (PAHs) by controlling their packing and architectures with suitable coformers. In this study, we demonstrate a supramolecular synthon substitution ap... |
41641348 | Critical Assessment of Intrinsic Antibacterial Properties and Photothermal Therapy Potential of MXene Nanosheets. | MXenes are well-known as highly biocompatible two-dimensional nanomaterials with a wide range of biomedical applications, including antibacterial strategies. However, the coexistence of high biocompatibility and reported strong antibacterial effects presents a fundamental contradiction that requires critical evaluation... |
41635917 | Navigating the next frontier in biomedicine: breakthroughs and insights in nucleic acid therapeutics. | Nucleic acid therapeutics are rapidly emerging as a transformative drug paradigm, offering precise and programmable regulation of gene expression across a broad spectrum of diseases. This review summarizes recent advances in key platforms-including antisense oligonucleotides, siRNA, miRNA, mRNA, and aptamers-emphasizin... |
41635431 | Examination of Replicate Syntheses of Metal Organic Frameworks as a Window into Reproducibility in Materials Chemistry. | Replicate experiments are a useful tool in understanding the repeatability of scientific measurements. In 2019, a systematic search for replicate syntheses of a collection of 130 metal-organic frameworks (MOFs) found that 89% of these materials had no reported replicate syntheses apart from the original publications id... |
41626509 | Protocell Computing on Aragonite Substrates. | Aragonite-proteinoid microstructures are an emerging type of biocomputing material. They mix inorganic calcium carbonate with self-assembled organic proteinoid networks. Scanning electron microscopy shows a range of structures. These include isolated microspheres and complex networks over 50 μm. They have dendritic sha... |
41626433 | Hydrophobicity Study of Melamine, 1,3,5-Benzenetricarbonitrile, and 1,3,5-Triaminobenzene. | The molecular hydrophobicity of melamine (MA), 1,3,5-triaminobenzene (TAB), and 1,3,5-benzenetricarbonitrile (BTCN) was investigated using various methods. Hydrophobicity is influenced by charge distribution, polar functional groups, and solvent interactions. Our findings indicate that at ultralow concentrations, these... |
41626195 | The interlocking process in molecular machines explained by a combined approach: the nudged elastic band method and machine learning potential. | Engineering molecular machines requires a precise knowledge of the mechanisms involved in programmed motions. Among artificial molecular machines, rotaxanes have emerged as a prominent model due to their ability to perform diverse and controlled motions, such as threading, shuttling, and pirouetting. In this work, we p... |
41624574 | Processing technology as aroma architect: OAV fingerprints decode differentiation and compatibility of key odorants in Fuding Dabai tea via GC×GC-TOF-MS and sensomics. | This study systematically investigates the regulatory role of processing technology in the aroma differentiation of Fuding Dabai tea (<i>Camellia sinensis</i>). Using an integrated sensomics approach combining quantitative descriptive analysis and GC × GC-TOF-MS, we deciphered aroma formation in green (GT), white (WT),... |
41624536 | pH-responsive ZIF-8@quercetin nanoparticles induce pyroptosis for targeted gastric cancer therapy. | Gastric cancer (GC) remains a major global health burden, with limited effective therapies and poor prognosis. Quercetin (Que), a natural flavonoid, exhibits anticancer activity but suffers from poor water solubility, limited oral bioavailability, and rapid metabolic clearance, which severely restrict its clinical tran... |
41623983 | Molecular mechanisms and functional implications of cyanidin-3-<i>O</i>-glucoside interactions with rice starch-protein binary matrix. | Rice starch-protein interactions significantly influence techno-functional properties and phenolic binding. This study elucidated the molecular mechanisms governing cyanidin-3-<i>O</i>-glucoside (C3G) interactions with rice starch-protein matrices containing varying protein levels (0-15% <i>w</i>/w). Protein contents o... |
41608680 | Enhancing gougerotin production by screening endogenous promoters for the transporter gene <i>gouM</i> in <i>Streptomyces albulus</i> CK-15. | <h4>Introduction</h4>Gougerotin is a nucleoside antibiotic that exhibits strong inhibitory effects against bacteria, as well as activities against plant viruses and pathogenic fungi, making it highly valuable for development and application. However, its widespread use is limited by low production yield and long fermen... |
41608435 | Necrotic pancreatitis: modern approaches to the prevention of infected necrosis. | The investigation of etiological factors in acute pancreatitis is a critical task, as their elucidation contributes to advancing both the diagnosis and prevention of the disease. Necrotizing pancreatitis (NP) is a severe complication of acute pancreatitis associated with high morbidity and mortality due to enzymatic ti... |
41608020 | PTX-loaded, polysorbate 80-functionalized brain-targeting pullulan nanoparticles for drug delivery. | Brain-targeted drug delivery remains a major challenge in pharmaceutical research. In this study, four types of polysorbate 80 and cholesterol-modified pullulan polymers (CHPP) were synthesized and self-assembled into nanoparticles (CHPP NPs) for brain drug delivery. The properties of these NPs, including brain targeti... |
41608026 | Antiviral activity of <i>Hellenia speciosa</i> (J. Koenig) S.R. Dutta rhizome metabolites against human adenovirus: insights from molecular docking and <i>in vitro</i> studies. | <h4>Background</h4>Human adenoviruses (HAdVs) cause a wide range of clinical diseases, yet effective antiviral therapies remain limited. Natural products, particularly medicinal plants, offer potential sources of antiviral agents.<h4>Purpose</h4>This study aimed to evaluate the antiviral potential of <i>Hellenia specio... |
41607902 | Genetic characterization of the respiratory tract viruses in Jilin, Northeast China, 2023. | <h4>Objective</h4>Respiratory viral infections impose a significant global health burden, necessitating continuous regional surveillance to understand pathogen circulation. This study aimed to characterize the spectrum of respiratory pathogens and identify potential causative agents in Jilin Province, northeast China, ... |
41607848 | Myostatin inhibition with orally administered <i>Lactobacillus casei</i> expressing a modified human myostatin protein: functional benefits and translational potential in advanced Duchenne muscular dystrophy. | <h4>Background</h4>Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disorder that requires novel therapeutic approaches beyond dystrophin restoration. Myostatin, a negative regulator of muscle growth, has emerged as a promising target to enhance muscle mass and function.<h4>Methods</h4>We evaluated the ... |
41607787 | Iron-fueled ferroptosis: a new axis for immunomodulation to overcome cancer drug resistance-from immune microenvironment crosstalk to therapeutic translation. | Resistance to chemotherapy and targeted therapy in cancer is largely due to evasion of apoptosis, but ferroptosis-an iron-dependent form of regulated cell death driven by lipid peroxidation-offers a promising alternative, particularly in aggressive and therapy-resistant subtypes. The tumor immune microenvironment plays... |
41607785 | From cercariae to chronic inflammation: understanding schistosome infection and host immune responses. | Schistosomiasis is a parasitic disease caused by trematodes of the genus Schistosoma, typically found in tropical and subtropical freshwater environments. Recognized by the World Health Organization as a major emerging disease, schistosomiasis is characterized by the parasite's ability to modulate and evade the host im... |
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