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41527999 | A Confined-Pyrolysis Strategy to Construct Magnetic Co@N-C Nanoreactors with Enhanced Peroxymonosulfate-Activated Metronidazole Degradation. | In this study, a novel Co-MOF (metal-organic framework), CUST-587, was successfully synthesized via a solvothermal method. A composite material of CUST-587 encapsulated by chitosan (CS), namely, CUST-587@CS, was prepared by a one-pot method. Further calcination resulted in the formation of magnetic nanomaterial Co@N-C-... |
41527890 | Extending the Distance Range in Double Electron-Electron Resonance Measurements of Transition Metal Clusters. | We report ligand manipulation of high-nuclearity, paramagnetic transition metal clusters based on heterometallic {Cr<sub>7</sub>Ni} rings to significantly prolong electron spin phase memory time constants. This enables the application of Double Electron-Electron Resonance (DEER) spectroscopy methods to measure cluster·... |
41527500 | CRISPR-on-Chip for Point-of-Care Diagnostics. | CRISPR-based diagnostic platforms have gained significant momentum in recent years, enabling highly sensitive and specific detection of pathogens and diseases. Due to their practical benefits, these platforms have become widely adopted in point-of-care (PoC) applications. CRISPR-on-chip technology integrates CRISPR-Cas... |
41527483 | Odorant and gustatory receptors synergistically modulate feeding behaviors that underlie food preference and consumption in the silkworm. | Feeding behavior determines insect survival and reproductive success. As insects process multimodal olfactory and gustatory cues to guide their feeding decisions, appetitive odors not only attract insects to food sources but also directly increase food ingestion. However, the mechanisms that coordinate chemosensory int... |
41527244 | Self-Powered Anti-Interference Photoelectrochemical Immunosensor Enabled by a Ferroelectric Hybrid Coupled with a Platinum-Doped Peptide Hydrogel. | Accurate and sensitive detection of biomarkers in complex biofluids is critical for early disease diagnosis and clinical monitoring but remains challenging due to nonspecific interference from abundant proteins and reducing agents. Here, we present a novel self-powered, anti-interference photoelectrochemical (PEC) immu... |
41526444 | Immunoinformatics-based design and evaluation of a multi-epitope vaccine against Vibrio fluvialis. | Vibrio fluvialis is an emerging foodborne pathogen causing gastroenteritis and extraintestinal infections, representing a significant public health concern due to rising antimicrobial resistance and the absence of an approved vaccine. This study aimed to design a multi-epitope subunit vaccine against V. fluvialis using... |
41489348 | Nanomedicines: an update of diagnostic and therapeutic applications in multiple cancers. | Cancer remains a major global health challenge, with existing diagnostic and therapeutic strategies often limited by poor selectivity, systemic toxicity and resistance. Nanomedicine - a convergence of nanotechnology and molecular medicine - offers promising solutions to these limitations by enabling more precise cancer... |
41427973 | A water-recyclable, robust, and self-healing sugar-based supramolecular network enabled by Maillard-analogous initialization of polymerization. | Crosslinked functional polymers exhibit exceptional mechanical and chemical properties critical for applications spanning biomedical engineering, advanced adhesives, and self-healing materials. However, challenges in recycling, either due to irreversible crosslinks or, in the case of covalent adaptable networks (CANs),... |
41427530 | Ferroptosis in renal cell carcinoma: integrative multi-omics insights and therapeutic perspectives. | Renal cell carcinoma (RCC) exhibits marked heterogeneity in its molecular landscape and clinical behavior. Ferroptosis, an iron-dependent and lipid peroxidation-driven form of cell death, has emerged as a biologically relevant process in RCC pathogenesis. This review summarizes recent advances in the multi-omics dissec... |
41427507 | Coordination interaction of Gd metal-organic frameworks and bismuth halides for efficient X-ray shielding. | X-ray radiation is widely used in industry, medicine, and space engineering, but its potential hazards necessitate effective shielding materials to protect both humans and the environment. Although lead (Pb) has been the conventional choice due to its high density (∼11.5 g cm<sup>-3</sup>) and atomic number (<i>Z</i> =... |
41417011 | Photopolymerized helical acrylate networks enable stable and full-color circularly polarized luminescence in perovskite nanocrystals. | Photopolymerized chiral polymer frameworks offer an unexplored strategy to couple structural confinement with optical activity in hybrid materials. Here, we introduce a confinement-driven design in which a photopolymerized hydrophobic helical acrylate network (DPAHA) simultaneously stabilizes and imparts chirality to a... |
41405276 | Self-assembly of lanthanide-based single-ion magnets (SIMs) into 1D networks <i>via</i> Re(IV)-based metalloligands. | Within the research field of molecular magnetism, single-ion magnets (SIMs) are of particular interest due to their ability to retain magnetic memory at the molecular level. At the same time, one-dimensional coordination polymers enable controlled spatial arrangement of magnetic centers, making them valuable models for... |
41396699 | Dual-function Ni-based MOF for hydrogen storage and CO<sub>2</sub> to carbonate cyclic catalysis. | International organizations highlight the need for technological progress with minimal environmental impact. In this context, we present Ni-URJC-3, a novel nickel-based metal-organic framework (MOF) with promising performance in H<sub>2</sub> and CO<sub>2</sub> adsorption and as a heterogeneous catalyst for cycloadditi... |
41392862 | Structural diversity in Zn(II)/Cu(II) complexes with salicylic/acetylsalicylic acids and bis(4-pyridylthio)methane: coordination polymers, one organic cocrystal, and one organic salt. | The solid-state chemistry of Zn(II)/Cu(II) salts with salicylic and acetylsalicylic acids and bis(4-pyridylthio)methane (SCS) was explored using various synthetic methods, leading to the isolation of several crystalline materials. These included three polymorphic forms of the one-dimensional coordination polymer 1∞Zn(H... |
41392707 | From discrete to polymeric assemblies: exploring supramolecular structural diversity in transition metal phosphinates with N-donor ligands. | A series of coordination complexes derived from diphenylphosphinic acid (DPP) and transition metal ions (Mn(II), Co(II), Ni(II), Cu(II), and Cd(II)) were developed in the presence of various N-donor ligands, including 4,4'-bipyridine (bpy), 1,2-bis(4-pyridyl)ethane (bpyea), 1,2-bis(4-pyridyl)ethene (bpyee), and 1,10-ph... |
41384614 | A stable amino-functionalized fluorinated metal-organic framework for efficient separation of propyne/propylene. | The separation of propylene (C<sub>3</sub>H<sub>6</sub>) is important in industry. Here, we report a highly stable fluorinated metal-organic framework, TNU-DPA-1. With a suitable pore size and abundant binding sites, it shows excellent C<sub>3</sub>H<sub>4</sub>/C<sub>3</sub>H<sub>6</sub> separation performance. In a d... |
41376471 | Cavity-size-directed supramolecular assembly of AIEgen networks for aqueous white-light emission. | We demonstrate a cucurbit[<i>n</i>]urils (CB[<i>n</i>])-based strategy to direct the emission of AIEgens. While CB[7] enhances fluorescence <i>via</i> molecular motion restriction, the larger CB[8] induces a blue shift and enables co-encapsulation for an efficient FRET system with an anthracene guest, achieving white-l... |
41376388 | Peptide-based drug design using generative AI. | Peptide-based therapeutics have emerged as a significant treatment strategy, offering high specificity and tunable pharmacokinetics. Recent advances in Artificial Intelligence (AI) have shifted the focus towards structure prediction, generative design, and interaction modelling, significantly accelerating drug design a... |
41368799 | Facile fabrication of a covalently-bonded carbon-sulfur composite from lignin for high-capacity potassium storage. | A carbon-sulfur composite with covalently bonded short-chain sulfur (∼27.5 wt%) was facilely synthesized <i>via</i> a one-step low-temperature (450 °C) heat treatment of the biomass lignin and cyclo-S<sub>8</sub>. As a K-ion battery anode, this composite exhibited a high reversible capacity of 596 mAh g<sup>-1</sup> wi... |
41367316 | Aerogel-inspired interfacial engineering of metal-organic framework and black phosphorus heterojunction for enhanced CO<sub>2</sub> photocatalytic reduction. | Photocatalytic reduction of CO<sub>2</sub> to value-added products shows promise for addressing energy and environmental challenges, but is constrained by inefficient charge separation and light utilization. We develop an aerogel-inspired mechanochemical strategy to fabricate NH<sub>2</sub>-UiO-66 and black phosphorus ... |
41363076 | A multiple signal-amplified electrochemiluminescence biosensor for ultrasensitive detection of bladder cancer-associated circRNA in urine. | An ultrasensitive electrochemiluminescence (ECL) biosensor was constructed for circular RNA detection by integrating an Fe-based metal-organic framework functionalized with gold nanoparticles (Fe-MOF@AuNPs) with rolling circle amplification (RCA) and cyclic amplification. The platform demonstrated excellent performance... |
41069300 | Mechanically robust and high latent heat solid-solid phase change materials <i>via</i> a H-bonding collaborative strategy for energy storage and conversion. | Solid-solid phase change materials (SSPCMs) historically struggle to achieve an optimal balance between mechanical robustness and efficient thermal energy storage (TES) capacity. To overcome this limitation, we engineered a hierarchical hydrogen-bond array by integrating quadruple hydrogen-bonded UPy dimers (strong bon... |
41065662 | Moderately polarized carborane-MOF with inverse C<sub>2</sub> selectivity for one-step polymer-grade ethylene purification. | Ethylene purification from ternary C<sub>2</sub> mixtures (C<sub>2</sub>H<sub>2</sub>/C<sub>2</sub>H<sub>4</sub>/C<sub>2</sub>H<sub>6</sub>) typically requires multi-step processes due to competing adsorption mechanisms in conventional adsorbents. Herein, we report a carborane-based metal-organic framework (CB-Zn-DPG) ... |
41044946 | Supramolecular crafting of peptides as novel antimicrobial materials. | Antimicrobial peptides (AMPs) have attracted great attention over the past few years as promising candidates to combat bacterial resistance. However, their small molecule nature poses limitations in stability, toxicity, and pharmacokinetics, restricting their <i>in vivo</i> and clinical uses. Supramolecular assembly of... |
41939214 | Multivalent Atezolizumab-Liposome Conjugates as Active Immunotherapeutic Platforms for Enhanced PD-L1 Blockade in Melanoma. | <h4>Purpose</h4>Anti-programmed death ligand-1 monoclonal antibody (anti-PD-L1 mAb) therapy has demonstrated notable clinical success. However, efficacy is often limited by transient interactions at the tumor-immune interface, limiting sustained immune activation. To address this, we hypothesized that liposomal deliver... |
41909136 | Unraveling Charge-Transfer States and Their Ultrafast Dynamics in Artificial Light-Harvesting Complexes. | Photosynthesis relies on highly organized pigment-protein complexes in order to store sunlight energy as biochemical energy. These complexes capture light with remarkable efficiency and are responsible for ultrafast charge separation within a finely tuned energy landscape provided by the protein environments, producing... |
41858587 | Nanozymes in Therapeutic Prospects and Challenges for Autoimmune Diseases. | Nanozymes are a class of nanomaterial-based catalysts with enzyme-like functionalities. They exhibit excellent physicochemical properties and stable catalytic activity in both in vivo and in vitro environments, demonstrating immense potential for biomedical applications. Autoimmune diseases arise from the immune system... |
41767480 | Machine Learning Framework for Characterizing Processing-Structure Relationship in Block Copolymer Thin Films. | The morphology of block copolymers (BCPs) critically influences material properties and applications. This work introduces a machine learning (ML)-enabled, high-throughput framework for analyzing grazing incidence small-angle X-ray scattering (GISAXS) data and atomic force microscopy (AFM) images to characterize BCP th... |
41765620 | Ultrasensitive molecularly imprinted Bi<sub>2</sub>S<sub>3</sub>/BiOCl heterojunction photoelectrochemical sensor for selective detection of oxytetracycline in food and environmental samples. | An ultrasensitive and selective molecularly imprinted photoelectrochemical (PEC) sensor utilizing a Bi<sub>2</sub>S<sub>3</sub>/BiOCl heterojunction is fabricated for the precise detection of oxytetracycline (OTC). The Bi<sub>2</sub>S<sub>3</sub>/BiOCl heterojunction is synthesized via a single-step hydrothermal proces... |
41704358 | Discovery of Dimer-Dependent Aminoacrylamide Molecular Glues for 14-3-3 Protein-Protein Interactions. | Molecular glues (MGs) offer a promising strategy for stabilizing protein-protein interactions (PPIs), particularly within the 14-3-3 protein family, which regulates diverse cellular processes and is implicated in many disease pathways. This study reports on the discovery of an aminoacrylamide MG (<b>7</b>) for 14-3-3 P... |
41684650 | Beyond wingtips: backbone alkylation affects the orientation of N-heterocyclic carbenes on gold nanoparticles. | The effect of wingtip groups on the orientation of N-heterocyclic carbene (NHC)-based self-assembled monolayers (SAMs) on a variety of metal surfaces has received considerable attention. However, the influence of backbone substituents on orientation has received virtually no attention, despite the fact that backbone in... |
41675737 | Social support and associated factors among diabetic patients in Bahir Dar, Ethiopia: a cross-sectional study. | <h4>Background</h4>Social support refers to the psychosocial resources available through interpersonal contacts and social networks, which help reduce complications and improve quality of life. It also decreases absenteeism from medical appointments, supports lifestyle changes, and plays a key role in self-management. ... |
41666668 | Effects of dietary fermented sweet potato residue on growth performance and cecal microbiota in sichuan white geese during the finisher period (28 to 70 days of age). | This study aimed to evaluate the potential of fermented sweet potato residue (FSPR) as a partial substitute for corn in goose diets, determine its optimal inclusion level, and assess its effects on intestinal morphology, immune status, and cecal microbiota. A 42-day feeding trial was conducted with 144 twenty-eight-day... |
41660257 | Biosynthesis of polyamine-polyphosphate granules for colitis alleviation. | Natural polyamines, such as spermidine and spermine, exert strong anti-inflammatory effects, but their therapeutic benefits are limited by rapid absorption in the small intestine, resulting in low colonic availability. In this study, engineered <i>Citrobacter freundii</i> overexpressing <i>ppk1</i> (CPP) could signific... |
41626472 | A Novel Approach to MOF-Anchoring Using Cross-Linked Polyaniline and Amine-Functionalized MOF to Generate Polymer-MOF Composites and Functionalized Graphite Electrodes. | This investigation explores a novel approach to MOF anchoring using cross-linked polyaniline (PANI-XL) and MIL-125-NH<sub>2</sub> via thermal treatment in THF to engineer an effective material for electrochemical devices. Successful synthesis of these materials was confirmed using FTIR spectroscopy, powder X-ray diffra... |
41626462 | Controlled Cisplatin Delivery Using pH-Sensitive PAA-Grafted Mesoporous Silica Nanoparticles. | More than 70% of patients with ovarian cancer are diagnosed with metastasis, in which tumors spread to the peritoneal cavity. The current standards of care are intravenous (IV) or intraperitoneal (IP) injection of small-molecule anticancer drugs, such as <i>cis</i>-diamminedichloro platinum-(II) (cisplatin). Although I... |
41626437 | New Macrocyclolipopeptides and Steroids from Mariana Trench-Derived Fungus <i>Cladosporium</i> sp. | Two unusual 13-membered macrocyclolipopeptides, cladosporiums A (<b>1</b>) and B (<b>2</b>), and four new steroids, cladosporisteroids D-G (<b>3</b>-<b>6</b>), were isolated from the Mariana Trench-derived fungus <i>Cladosporium</i> sp. RCDB004. Cladosporiums A (<b>1</b>) and B (<b>2</b>) possess an unprecedented macro... |
41624989 | Bisphenol A-responsive microgel comprising hydrophilic poly(acrylamide) network. | Stimuli-responsive microgels that exhibit rapid changes in size in response to external stimuli such as pH and temperature are of great interest for the development of smart sensors, drug delivery carriers, and separation materials. This paper describes the preparation of molecule-responsive microgels with molecular re... |
41623964 | The combined effects of konjac glucomannan and ultrasound treatments on the interaction of gluten and surimi protein. | The novel alternative of nutrition balance with plant and animal proteins is becoming the main component of nutrition in the modern diet. The properties of gluten, surimi and gluten/surimi mixture (GS) were analyzed after treatment with Konjac glucomannan (KGM), ultrasound (U) and Konjac glucomannan ultrasound (UKGM). ... |
41614185 | Gold-Catalyzed Carbonyl Release and its Adaptation for Prodrug Therapy Using Multivalent Lectin-Directed Artificial Metalloenzymes. | In the framework of developing artificial metalloenzyme (ArM) prodrug therapies, two main factors need to be considered; the cancer targeting capabilities of the ArM biocatalyst and the bioorthogonal prodrug activation mechanism. In this study, both these aspects were investigated to develop an example of an anticancer... |
41614164 | Structure-Based Design of Covalent SARS-CoV‑2 Main Protease Inhibitors Targeting the Nirmatrelvir-Resistant E166 Mutants. | The COVID-19 pandemic spurred the rapid development of nirmatrelvir, a main protease (M<sup>pro</sup>) inhibitor now widely prescribed as part of Paxlovid (nirmatrelvir plus ritonavir). However, increasing use has raised concerns about drug resistance. Resistance selection studies have identified multiple M<sup>pro</su... |
41602825 | Progress on the mechanism of Polycystin-1 in bone remodeling. | Polycystin-1 (PC-1), a transmembrane protein expressed on cell membranes, plays a vital role in cell signaling and intercellular adhesion. Existing studies have shown that PC-1 plays a pivotal role in bone remodeling and that PC-1 deficiency results in disrupted bone remodeling, which markedly affects bone mass and ske... |
41602769 | Biofilm-mediated immune dysregulation in chronic pulmonary diseases: mechanisms and clinical implications. | Microbial biofilms are increasingly recognized as critical modulators of chronic airway inflammation and immune dysregulation in pulmonary diseases. This review summarizes current evidence on how biofilm formation and persistence alter host immune responses, contributing to the pathogenesis of chronic lung disorders. W... |
41602762 | Broadly neutralizing monoclonal antibodies against influenza A viruses: current insights and future directions. | Monoclonal antibodies (mAbs) have become attractive tools for both the treatment and prevention of influenza A viruses due to their ability to target several viral components, which confers broad therapeutic potential. Advances in biotechnology, such as hybridoma technology, phage display technology, B cell immortaliza... |
41602760 | <i>In vitro</i> study on anti-<i>Helicobacter pylori</i> effects of DL-3-n-butylphthalide-loaded silk fibroin nanoparticles. | <i>Helicobacter pylori</i> (<i>H. pylori</i>) primarily colonizes the gastric mucosal epithelium in humans and is considered the strongest risk factor for gastric cancer. Current clinical eradication regimens rely on proton pump inhibitor (PPI)-based triple or quadruple antibiotic therapies. However, rising antibiotic ... |
41602537 | Pre-harvest cinnamic acid and potassium cinnamate improve postharvest quality and storability of 'Kyoho' grapes. | Frequent high temperatures render 'Kyoho' grapes prone to postharvest softening, berry drop, and insufficient coloration. To address these challenges, this study investigated the effects of preharvest foliar sprays of cinnamic acid (CA) and potassium cinnamate (PC) on fruit quality and storability. Grapes were treated ... |
41602545 | Bromo- and chloro-substituted flavones induce apoptosis and modulate cell death pathways in canine lymphoma and leukemia cells - a comparative <i>in vitro</i> study. | <h4>Introduction</h4>Although flavonoids are natural compounds with anti-cancer potential, their clinical application is limited due to the low bioavailability. Structural modification, such as halogenation, has been identified as a strategy to enhance drug-like properties. The rationale behind this is that halogen sub... |
41602478 | Carbon nanotubes for wound healing: material design, mechanistic insights. | Chronic wounds such as diabetic ulcers remain significantly higher in global healthcare burden due to impaired angiogenesis, infection, and sustained inflammation. Carbon nanotubes (CNTs) are promising candidates for advanced wound-dressing applications due to their exceptional electrical conductivity, high mechanical ... |
41602456 | Chemical analysis of extracellular vesicles by synchrotron-based X-ray imaging and scattering techniques: a review and perspective. | Extracellular vesicles (EVs) are nanoscale lipid bilayer-enclosed particles released by cells, which have been explored as pivotal mediators for intercellular communication, biomarkers for diseases and nano-carriers for drug delivery. Unraveling their structural and chemical heterogeneity is crucial for understanding t... |
41602274 | Food contaminants: mechanisms of toxicity, computational assessment, and mitigation. | Understanding the toxicological mechanisms of food contaminants is critical for assessing risks to human health. This review comprehensively examines their adverse effects, tracing the pathway from molecular initiation to systemic organ-level damage. A central focus is placed on the growing trust on computational metho... |
41602284 | Surface-enhanced Raman spectroscopy for label-free cancer liquid biopsy: from fundamentals to clinical analysis of biofluid. | Cancer remains one of the major public health problems due to its high morbidity and mortality globally. Because metastasis is the major cause of cancer death, developing new approaches for early diagnosis is of paramount importance in this context. Surface-enhanced Raman scattering (SERS) has emerged as a cutting-edge... |
41602141 | Rotational symmetry dication assembling ferroelectric, thermochromic and circularly polarized luminescent multifunctional manganese(ii) bromide hybrid. | Noncentrosymmetric (NCS) structure crystalline materials exhibit a range of high-tech applications; however, the controllable synthesis of NCS materials using achiral molecular building blocks remains a great challenge. Herein, we present a crystal engineering strategy for constructing NCS multifunctional materials. We... |
41602117 | Fenofibrate suppresses <i>Mycoplasma bovis</i> infection via autophagy-mediated cholesterol regulation in bovine mammary epithelial cells and murine mammary tissue. | <h4>Background</h4><i>Mycoplasma bovis</i> mastitis is an important disease of dairy cows; however, there are no commercial <i>M. bovis</i> vaccines and antimicrobial resistance is increasing. Furthermore, <i>M. bovis</i> lacks a cell wall and relies on host-derived cholesterol for survival and growth.<h4>Methods</h4>W... |
41602110 | Targeting <i>Helicobacter pylori</i> enzymes using <i>Viscum album</i> L. extract: <i>in silico</i> molecular docking and <i>in vitro</i> study. | <i>Viscum album</i> L. (mistletoe) is a hemiparasitic plant known for its wide range of bioactive compounds, including phenolics, flavonoids, and lectins, which contribute to its diverse pharmacological properties. In the present study, we focused on identifying and quantifying the phenolic compounds present in <i>V. a... |
41601986 | Bile acids as therapeutic agents. | Bile acids (BAs) are amphiphilic molecules traditionally recognized for their role in lipid digestion but have gained increased interest for their therapeutic potential. Among them, ursodeoxycholic acid (UDCA) is the most widely prescribed and has been FDA-approved in the treatment of primary biliary cholangitis (PBC),... |
41601981 | Metabolite and gut microbiota co-biomarkers in Danggui Shaoyao San: insights into a shared therapeutic approach. | Danggui Shaoyao San (DSS), a classical multi-herbal formulation of traditional Chinese medicine, demonstrates therapeutic potential for Type 2 Diabetes Mellitus (T2DM), Alzheimer's Disease (AD), and Polycystic Ovary Syndrome (PCOS). This review proposes a unified mechanism whereby DSS exerts its effects by modulating a... |
41601977 | Bromhexine inhibits SARS-CoV-2 Omicron and variant pseudovirus infection via ACE2-targeted mechanisms. | <h4>Background</h4>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a highly infectious disease characterized by fever, acute respiratory illness, and pneumonia, known as coronavirus disease 2019 (COVID-19). SARS-CoV-2 infects host cells through the interaction of its spike glycoprotein (S protein) w... |
41601966 | X-inactive specific transcript (XIST) can determine sex differences in cardiovascular drug responses: focus on RNA therapeutics. | Genetic, hormonal, anatomical, and environmental factors underlie sex differences in the prevalence and progression of cardiovascular disease and responses to therapeutics. The presence of two X chromosomes in the female genome decreases susceptibility to X-linked recessive disorders but imposes the need for random X c... |
41601970 | Computational-experimental integration identifies potent carbohydrate-hydrolyzing enzyme inhibitors from <i>Nardostachys jatamansi</i>: molecular docking, dynamics and pharmacokinetic predictions. | <h4>Background</h4>Current α-glucosidase and α-amylase inhibitors demonstrate limited therapeutic efficacy and significant gastrointestinal side effects, necessitating identification of novel antidiabetic agents. This study employed integrated computational and experimental approaches to evaluate carbohydrate hydrolyzi... |
41601960 | Combining exercise and nanoparticle-based therapies: a review of physiological synergies and pharmacological potential. | The convergence of nanotechnology and exercise science represents a novel pharmacological approach to enhance therapeutic efficacy, physiological resilience, and performance outcomes. Exercise is known to induce systemic adaptations-such as improved mitochondrial biogenesis, enhanced antioxidant defense, and neuroplast... |
41601956 | Aloe-emodin: from pharmacological mechanisms to clinical applications and future perspectives. | Natural products continue to be fundamental to contemporary drug discovery. Aloe-emodin, a natural anthraquinone molecule sourced from plants including aloe and rhubarb, has attracted considerable interest owing to its diverse pharmacological properties. This review analyzes the complex modes of action of AE, emphasizi... |
41601922 | Histone-modifying enzymes as drivers and therapeutic targets in androgen-resistant prostate cancer. | Androgen deprivation therapy (ADT) remains the cornerstone of treatment for advanced, hormone-sensitive prostate cancer (HSPC), but responses are transient, and most patients ultimately develop castration-resistant prostate cancer (CRPC), a largely incurable stage of disease. The mechanisms driving resistance are not y... |
41601899 | Camel hump oil and milk vs. plant-based oils in aging-related oxidative stress and inflammation: a systematic review and meta-analysis. | <h4>Background</h4>Camel hump oil (CHO) is high in unsaturated fatty acids, tocopherols, and bioactive lipids, and it has long been used in Arabian medicine. While camel milk has been extensively studied for its antioxidant and anti-inflammatory properties, direct information on CHO anti-aging is limited. This study ai... |
41601897 | Nanoencapsulation of nutraceuticals: enhancing stability and bioavailability in functional foods. | While nutraceuticals hold great promise for improving health, their efficacy is often limited by the poor stability and low bioavailability of many bioactive compounds. Nanoencapsulation has emerged as a transformative solution to these challenges, involving nanoscale carriers that protect sensitive nutrients from degr... |
41601878 | <i>Platycodon grandiflorum</i>: from phytochemical diversity to polysaccharides' prominent bioactivities and edible-medicinal applications. | <i>Platycodon grandiflorum</i> (<i>P. grandiflorum</i>), a plant traditionally recognized for its dual application in medicine and food, is extensively utilized in East Asian traditional practices and culinary arts. This review consolidates recent findings on the phytochemical composition of <i>P. grandiflorum</i>, wit... |
41601701 | T cell assays for non-clinical immunogenicity risk assessment: best practices recommended by the European Immunogenicity Platform. | <i>In vitro</i> and <i>in silico</i> tools help drug developers reduce unwanted immunogenicity of biologics at the design stage. These include assays that examine different immune system processes leading to anti-drug antibody (ADA) or cytotoxic cellular response development, such as activation and peptide presentation... |
41601690 | Targeting the plasticity of intestinal neutrophils: bidirectional regulation strategies by natural products. | Historically, neutrophils have been regarded primarily as pro-inflammatory cells, yet recent advancements have revealed their phenotypic heterogeneity and functional plasticity with versatile immunophenotypes. Distinct subpopulations of neutrophils exhibit a functional duality, not only initiating and amplifying inflam... |
41601659 | Susceptibility of broad reactivity nanobodies to resistance mutations in the S2 domain of SARS-CoV-2 predicted by yeast display deep mutational scanning. | <h4>Introduction</h4>The rapid evolution of SARS-CoV-2 has led to the erosion of vaccine induced serum neutralization and monoclonal antibody efficacy. As such, interest is inevitably moving towards more conserved regions of the SARS-CoV-2 spike protein like the S2 domain. Resistance mutations continue to be a major ob... |
41601640 | Construction of anti-HER2 affibody-directed CAR-NK and its synergistic effects with doxorubicin-loaded nanodrug against HER2-positive breast cancer. | <h4>Introduction</h4>Chimeric antigen receptor (CAR)-engineered T or natural killer (NK) cells are a promising approach for cancer immunotherapy. The leading region of the CAR structure is generally a single-chain antibody (scFv) fragment specific for a tumor cell surface molecule, and other structures are rarely repor... |
41601631 | Personalized neoantigen DC vaccine combined with camrelizumab following definitive therapy in locally advanced unresectable esophageal squamous cell carcinoma (CHANT-241): protocol for a randomized controlled trial. | <h4>Importance</h4>Locally advanced, unresectable esophageal squamous cell carcinoma (ESCC) has a poor prognosis despite definitive chemoradiotherapy (CRT), and no standard maintenance therapy currently exists. Personalized vaccines targeting tumor neoantigens combined with immune checkpoint inhibitors may enhance anti... |
41601627 | Impact of Epstein-Barr virus infection on clinical outcomes and immune profiles in patients with severe fever with thrombocytopenia syndrome. | <h4>Background</h4>Epstein-Barr virus (EBV) infection is frequently observed in patients with severe fever with thrombocytopenia syndrome (SFTS), yet its clinical significance remains unclear. This study aimed to characterize the impact of EBV infection on clinical outcomes and the associated immunological and inflamma... |
41601534 | Potential molecular pathways and therapeutic implications of rapid-acting antidepressants on myelin biology: a scoping review. | <h4>Background</h4>Emerging evidence indicates that rapid-acting antidepressants (RAADs)-including ketamine and serotonergic psychedelics- may affect myelin homeostasis, aside from producing fast-onset, sustained improvements in several psychiatric disorders.<h4>Methods</h4>A systematic search of PubMed (MEDLINE), Web ... |
41600997 | Plant Viral Vectors for Vaccine Development. | Plant viruses are useful tools for quickly and easily producing recombinant proteins in plants. Compared to systems that use genetically modified plants, viral vectors are easier to work with and can produce recombinant proteins faster and in larger amounts. Recently, there has been growing interest in using plant viru... |
41600863 | Chikungunya in 2025: Comprehensive Insights into Virology, Diagnostics, Vaccines, and Antiviral Therapies. | Chikungunya virus (CHIKV) is a mosquito-borne alphavirus prevalent in more than 110 countries and regions, including Africa, Asia, the Americas, and Europe. It can cause acute fever, rash, and severe joint pain, and some patients may develop chronic arthritis, which significantly impairs quality of life. CHIKV infectio... |
41600295 | Design and Applications of MOF-Based SERS Sensors in Agriculture and Biomedicine. | Metal-organic framework (MOF)-based surface-enhanced Raman scattering (SERS) sensors have emerged as a versatile platform for high-sensitivity and selective detection in agricultural, environmental, and biomedical applications. By integrating plasmonic nanostructures with tunable MOF architectures, these hybrid systems... |
41600287 | Recent Advancements in the SERS-Based Detection of <i>E. coli</i>. | <i>Escherichia coli</i> (<i>E. coli</i>) is a well-established indicator of faecal pollution and a potent pathogen linked to numerous gastrointestinal and systemic illnesses. Ensuring public safety requires rapid and sensitive detection methods capable of real-time, on-site deployment. Many conventional techniques are ... |
41599726 | State of the Art and Development Trends in Obtaining Fast-Dissolving Forms of Creatine Monohydrate. | Creatine monohydrate is known for its moderate solubility (13 g/L at 25 °C), which limits the feasibility of producing its fast-dissolving forms. Overcoming this limitation is possible through the application of technological approaches, the overview of which is presented in this work, including chemical modification, ... |
41599204 | Efficient Oral Insulin Delivery Through Thiolated Trimethyl Chitosan-Grafted β-Cyclodextrin Nanoparticles. | <b>Background</b>: Oral insulin improves compliance and convenience in patients with diabetes who require regular needle injections. However, the clinical application of oral insulin preparations has been limited due to instability and inefficient permeation through the gastrointestinal tract. In this study, a novel ca... |
41599210 | The Activity of FDA-Approved Prodrug Isavuconazonium Sulfate and Its Major Metabolite Isavuconazole Against <i>Naegleria fowleri</i>. | <b>Objectives</b>: Free-living amoeba <i>Naegleria fowleri</i> causes primary amoebic meningoencephalitis (PAM). While infection is rare, PAM's fatality rate exceeds 97%. The recommended treatment includes combination therapy, which does not result in uniform survival. Thus, there is a critical unmet need for finding b... |
41598006 | Electronic Structure of Graphene-Doped PEDOT:PSS and Its Influence on Energy-Level Alignment with p-Type Organic Semiconductor ZnPc. | Poly (3,4-ethylenedioxythiophene polystyrene sulfonate) (PEDOT:PSS) is a solution-processable hole transport layer known for its high work function and excellent hole mobility. The incorporation of graphene serves as an effective strategy to augment the hole-transport properties of PEDOT:PSS. In this study, the electro... |
41597205 | Enhancing the Nucleoside Analog Response with Translational Therapeutic Approaches to Overcome Resistance. | Nucleoside analogs remain central to the treatment of hematologic malignancies and solid tumors, yet resistance frequently occurs, contributing to relapse and disease-related mortality. Rather than arising from a single mechanism, effective nucleoside analog activity requires successful navigation of multiple biologica... |
41596878 | Preparation, Separation, and Identification of Low-Bitter ACE-Inhibitory Peptides from Sesame (<i>Sesamum indicum</i> L.) Protein. | To prepare and characterize low-bitter angiotensin-converting enzyme (ACE)-inhibitory peptides from sesame protein, a triple-enzyme hydrolysis system was optimized using mixture design and response surface methodology. The resulting hydrolysate was separated by ultrafiltration and medium-pressure chromatography, follow... |
41596876 | Novel Applications of Starch and Starch Derivatives in the Food and Alcoholic Beverages Industry: A Review. | Starch and its derivatives have undergone substantial advancement in the food and beverage industry, driven by growing demand for improved functionality and health-promoting attributes. Native starches are widely used as thickeners and stabilizers; however, their applications are limited by deficiencies such as poor fr... |
41596399 | Berberine: A Negentropic Modulator for Multi-System Coordination. | Berberine (BBR), a protoberberine alkaloid with a long history of medicinal use, has consistently demonstrated benefits in glucose-lipid metabolism and inflammatory balance across both preclinical and human studies. These diverse effects are not mediated by a single molecular target but by BBR's capacity to restore net... |
41596018 | Toward Nanodisc Tailoring for SANS Study of Membrane Proteins. | Although membrane proteins are of major importance in both physiology and disease, they remain less studied than soluble proteins due to the complex amphiphilic environments required to preserve their structure and function. As a consequence, membrane proteins are under-represented in structural databases. In this work... |
41596012 | Bioengineered Cellular and Acellular Therapies for Ischemic Heart Disease in Clinically Relevant Models. | Despite significant improvements in revascularization strategies and medical management, ischemic heart disease (IHD) remains the top cause of mortality and disability worldwide. The myocardium lacks regenerative capacity and consequently, recovery depends on re-establishing microvascular integrity and sustaining angio... |
41594667 | Inorganic Polyphosphate in Mammals: Mechanisms, Maladies, and Moving Forward. | Inorganic polyphosphate is highly conserved, critical, yet poorly understood polymer that regulates diverse cellular functions in mammals. Its importance is well established in coagulation, inflammation, mitochondrial function, and stress responses, though the molecular mechanisms for these effects remain only partly u... |
41594669 | Artificial Intelligence for Natural Products Drug Discovery in Neurodegenerative Therapies: A Review. | This review examines the application of Artificial Intelligence (AI) in the discovery and optimisation of neuroprotective natural products (NPs) for neurodegenerative diseases (NDDs), emphasising the transition from general computational drug discovery to AI-specific approaches designed to address the chemical complexi... |
41591020 | Graphene/CNT Nanocomposites: Processing, Properties, and Applications. | Carbon nanotube (CNT) and graphene-reinforced nanocomposites have become exceptional multifunctional materials because of their exceptional mechanical, thermal, and electrical properties. Recent developments in synthesis methods, dispersion strategies, and interfacial engineering have effectively overcome agglomeration... |
41590093 | Preparation of CO<sub>2</sub>-Adsorbing Fire-Extinguishing Gel and Study on Inhibition of Coal Spontaneous Combustion. | Spontaneous coal combustion accounts for more than 90% of mine fires, and at the same time, the 'dual carbon' strategy requires fire prevention and extinguishing materials to have both low-carbon and environmentally friendly functions. To meet on-site application needs, a composite gel with fast injection, flame retard... |
41585557 | Au/Ir@Zn/Cu-MOF-based lateral flow immunoassay employing high-affinity monoclonal antibody for sulfamethoxazole detection. | Sulfamethoxazole (SMX) is a widely used sulfonamide antibiotic, and its residues in animal-derived foods pose significant health risks. In this study, a high-affinity monoclonal antibody (2.65 × 10<sup>10</sup> L/mol) against SMX was developed and used to construct an Au/Ir@Zn/Cu-MOF-based lateral flow immunoassay (LFI... |
41584078 | Monocyte/macrophage-mediated trained immunity in disease prevention and immunotherapy. | Trained immunity refers to a functional reprogramming of the innate immune system that enhances its ability to respond to secondary stimuli. Monocytes and macrophages are central effectors of innate immunity with broad therapeutic relevance. Their capacity to acquire trained immunity enhances host defense and shapes im... |
41573122 | Electrosynthesis of 2,5-furandicarboxylic acid from 5-hydroxymethylfurfural: mechanisms, advanced catalysts, and reaction microenvironments. | As the sole renewable source of organic carbon, biomass is indispensable to the green transition, offering both abundance and carbon neutrality. The biomass-derived platform molecule, 5-hydroxymethylfurfural (HMF), can be valorized into various high-value chemicals <i>via</i> oxidation. Most notably, 2,5-furandicarboxy... |
41548475 | Targeting TatD nuclease and the MAPK Pathway: Luteolin multifaceted approach against Mycoplasma gallisepticum infection. | Nucleases are considered to be a key virulence factor of Mycoplasma gallisepticum (MG) and targeting nucleases is considered a novelly and potential direction for developing anti-MG drugs. The TatD nuclease localizes to the MG cell cytoplasm and can be released via extracellular vesicles (EVs), enabling it to participa... |
41547167 | Pasture grazing reduces the incidence of hepatic osteodystrophy in meat-type geese: Insights from the liver bone axis. | Hepatic osteodystrophy, a metabolic bone disorder associated with chronic liver disease, is characterized by reduced bone mass and structural deterioration. While the liver-bone axis is increasingly recognized as a critical mediator of systemic inflammation and hepatic pathology, the efficacy of nutritional strategies ... |
41544507 | Phytochemicals self-assemblies: Bridging biomedicine and agriculture for next-generation crop protection. | Conventional pesticides face persistent challenges of instability, rapid wash-off, and resistance, while synthetic nanocarriers often suffer from poor degradability, scalability barriers, and regulatory uncertainty. Phytochemical self-assemblies (Phyto-SANs), defined in this review as carrier-free nanoassemblies constr... |
41544342 | Discovery of a novel PI3Kα inhibitor for breast cancer therapy via virtual screening method, molecular dynamics simulation and biological evaluation. | Phosphatidylinositol-4,5-bisphosphate 3-kinase alpha (PI3Kα) is a central signaling enzyme driving cell proliferation and growth in cancers including breast cancer. Selective inhibition of PI3Kα isoform has become a promising therapeutic approach. In this work, 2000 in-house natural compounds were virtually screened ag... |
41544319 | Biomimetic cascade "four-in-one" Nanozyme for remodeling the redox tumor microenvironment and disrupting energy homeostasis to enhance ferroptosis against triple-negative breast cancer. | Ferroptosis, a promising therapeutic strategy for triple-negative breast cancer (TNBC), faces significant challenges due to intrinsic tumor defense mechanisms. To enhance ferroptosis against TNBC, a biomimetic "four-in-one' cascade nanozyme AuPd/Cu<sub>2</sub>O@Cancer cell membrane (APCM) was engineered to remodel tumo... |
41538520 | A comparison of the cost-effectiveness of the current standard of care and of the haematology analyser XN31-microscopy combination for diagnosing malaria in a nonendemic country. | <h4>Background</h4>The biological diagnosis of imported malaria cases is a challenge that requires efficient methods, trained staff and high-quality proficiency. Microscopy, rapid diagnosis tests and molecular tests are widely available and provide excellent results. New methods such using haematology analysers have be... |
41534837 | HMGB1 binds to and disrupts the hairpin structure of RNA15 and inhibits toll-like receptor activation. | Toll-like receptor 13 (TLR13) is a critical innate immune sensor that recognizes a conserved RNA sequence, RNA15 (2054-2068, ACG GAA AGA CCC CGU), within bacterial 23S rRNA, thereby initiating a proinflammatory response. While the alarmin high mobility group box 1 (HMGB1) is known to modulate various TLR pathways, its ... |
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