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41534553 | Bio-inspired supramolecular hydrogel inhibits ferroptosis to accelerate diabetic wound healing. | <h4>Introduction</h4>Ferroptosis significantly compromises diabetic wound healing and represents a promising therapeutic target for clinical intervention. Baicalein (Bai), a natural flavonoid, has been considered to own ferroptosis-regulating properties, while the underlying mechanisms remain understood.<h4>Objectives<... |
41534501 | Amino acid-based modulation of enzyme-metal organic frameworks (MOFs) composites: A conceptual perspective. | An amino acid-assisted fabrication of enzyme-MOF composites represents a novel approach for enhancing biocatalyst performance through molecular-level interactions. The flexible roles of amino acids as modulators, linkers, defect inducers, and microenvironmental regulators inside MOF systems for enzyme immobilization ar... |
41531938 | Theranostic advances in Alzheimer's disease: structure-guided design of near-infrared fluorescent probes targeting amyloid-β and cholinergic dysfunction. | Alzheimer's disease (AD) is a complex neurodegenerative disorder, with unmet clinical challenges due to the lack of early diagnosis and an efficient treatment. Theranostics, an integrated approach that combines diagnosis and therapy, has emerged as a viable option, particularly with the use of near-infrared fluorescenc... |
41531770 | π-hole forces enabled programmable supramolecular chirality based on a chiral benzimidazole pincer. | Employing noncovalent forces to fabricate self-assembled nanoarchitectures composed of multiple constituents regulates the expression of chirality across hierarchical levels. Here we report a programmed hierarchical chiral assembly through π-hole interactions synchronized with hydrogen bonding. A chiral molecular pince... |
41531773 | Designing single-atom catalysts: bridging metal-support interaction and adsorption energy optimization. | Single-atom catalysts (SACs) offer exceptional potential for the oxygen evolution reaction (OER), yet their practical application is hindered by an incomplete understanding of structure-activity relationships at the atomic scale. Traditional descriptors fail to fully explain the adsorption behavior of key oxygen interm... |
41531755 | Complete stereochemical control to unlock monosign circularly polarised luminescence with superior circularly polarised brightness for chameleon security inks. | A novel arylalkynylpyridine-sensitised nine coordinate quasi-<i>C</i> <sub>3</sub> symmetric all carboxylate donor europium(iii) complex (EuL) possessing exceptionally high circularly polarised brightness in both Δ<i>J</i> = 1 and Δ<i>J</i> = 2 transitions was prepared and tested in spin-coated solid-state PMMA thin fi... |
41531528 | Synergizing advanced materials and artificial intelligence for next-generation carbon capture, utilization, and storage (CCUS): a review. | The increasing rate of global carbon dioxide (CO<sub>2</sub>) emissions, mainly resulted from the industrial and energy sectors is a serious global challenge for climate stability. Carbon Capture, Utilization, and Storage (CCUS) technologies are being considered as important route to achieve the decarbonization objecti... |
41531517 | Hydrolysis mechanisms for A-series (Novichok) nerve agents at different pH V and computational simulant screening. | A-series nerve agents (Novichok agents) are ultratoxic organophosphorus agents that were listed in Schedule 1 of the Chemical Weapons Convention in 2019. Their extreme acute toxicity precludes direct experimental manipulation, and theoretical investigations into their aqueous degradation mechanisms and safe simulant de... |
41531515 | Advancing total synthesis through the Stille cross-coupling: recent innovations and case studies. | The Stille reaction, a pivotal palladium-catalyzed cross-coupling, continues to drive advancements in the total synthesis of highly complex natural products, pharmaceuticals, and functional materials. Originating from <i>John K. Stille</i>'s foundational work, this method has evolved through innovations in catalysis, l... |
41531514 | Covalent organic imine polymer containing benzothiadiazole as a bifunctional material for specific fluorescence detection and removal of Hg<sup>2</sup>. | As one of the most toxic heavy metals to humans and the environment, achieving simultaneous fluorescence detection and effective removal of Hg<sup>2+</sup> presents a significant challenge. In this study, we combined the excellent photoelectric properties of benzothiadiazole groups with the porous structure of covalent... |
41531513 | Scalable synthesis of N,S co-doped honeycomb-like porous carbon with micropore-dominance for ultrahigh volumetric-performance supercapacitors. | The conversion of low-cost, sustainable biomass into high-value porous carbon as an electrode material for supercapacitors has attracted considerable recent attention. Almost all efforts are focused on developing advanced carbon electrode materials without conducting large-scale experiments. Utilizing cotton pulp board... |
41530974 | Seed-microbiome interactions: Mechanistic insights and utilization toward seed performance for sustainable agriculture. | Global climate change poses increasing threats to seed production and, consequently, global food security. The seed microbiome plays an essential role in regulating the entire seed life cycle. Specific seed endophytes and spermosphere microorganisms orchestrate the maintenance and release of dormancy, thereby synchroni... |
41529491 | Molybdenum oxide based electrode materials for electrochemical sensing applications: Recent progress in electrode modifiers. | Recent years have observed the rapid growth in the fabrication of electrochemical sensors using metal oxides and their hybrid composites for environmental monitoring applications. It was also found that electrochemical sensors or biosensors may also use in clinical diagnostic for the determination of small biomolecules... |
41528848 | Biophysical modeling identifies an optimal hybrid amoeboid-mesenchymal mechanism for maximal T cell migration speeds. | Despite recent advances in cell migration mechanics, the principles governing rapid T cell movement remain unclear. Efficient migration is critical for antitumoral T cells to locate and eliminate cancer cells. To investigate the upper limits of cell speed, we develop a hybrid stochastic-mean field model of bleb-based c... |
41527445 | Zinc Phthalocyanine Nanoassemblies Regulated by Polyethylene Glycol Chains for Synergistic Phototherapy. | Modulating the structure of nanoassemblies to achieve the desired properties remains a challenge. In this study, we present a strategy for regulating nanoassembly by introducing different numbers of polyethylene glycol (PEG) chains to control the self-assembly behavior of zinc phthalocyanine. The morphology, water solu... |
41527438 | Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment. | Biomimetics is an interdisciplinary field that involves studying the structures, functions, principles, and behaviors of biological systems to draw inspiration and apply this knowledge to technological innovation and engineering design, thereby addressing complex challenges. Biomimetic nanomedicine represents a spe... |
41527410 | Non-Equilibrium Synthesis Methods to Create Metastable and High-Entropy Nanomaterials. | Stabilizing multiple elements within a single phase enables the creation of advanced materials with exceptional properties arising from their complex composition. However, under equilibrium conditions, the Hume-Rothery rules impose strict limitations on solid-state miscibility, restricting combinations of elements with... |
41527268 | Human Brain Vasculature-on-a-Chip Model Constructed With Microvessels Isolated From Cryopreserved Postmortem Human Brain Tissue. | Brain vasculature is a complex and heterogeneous structure that serves specialized roles in maintaining brain health and homeostasis. There is substantial interest in developing representative human models of the brain vasculature for drug screening and disease modeling applications. Many contemporary strategies have f... |
41527263 | Amplified Circularly Polarized Luminescence of Chiral AIE-active Tetraphenylbutadiene Derivatives in Nematic Liquid Crystal. | Circularly polarized luminescent (CPL) materials featuring high luminescence dissymmetry factors (g<sub>lum</sub>), high photoluminescence quantum yields (Φ<sub>PL</sub>), and tunable emission properties are essential for practical applications. Herein, three chiral aggregation-induced emission (AIE) tetraphenylbutadie... |
41527231 | Atomically Precise Metal Nanoclusters for Near-Infrared-II Photonics. | ConspectusLight in the near-infrared-II (NIR-II, 1000-2500 nm) region has enabled groundbreaking advances in photonic technologies, including long-distance optical communication, deep-tissue optical imaging, noninvasive neuromodulation, and high-efficiency solar energy conversion. Traditional NIR-II-responsive material... |
41527192 | Nanodiamond Regulated Electrolyte Enhances Thermal, Chemical and Structural Properties for Highly Reversible Zn Metal Anodes. | Aqueous zinc-ion batteries (AZIBs) suffer from inevitable internal resistance-induced heat generation and competing hydrogen evolution, leading to high external cooling energy consumption and potential safety hazards. In this report, an electrolyte engineering strategy is proposed, involving nanodiamond (ND) additives ... |
41527178 | Rotating Magnetic Field-Enabled Metasurface-Regulated Luminescence Strategy for Extracellular Vesicle Detection. | Metasurface was a 2D array of subwavelength artificial structures capable of regulating nanoscale optical fields. Although the metal-based metasurface exhibited notable localized field enhancement effects, its static optical responses and ohmic losses limited further development. Magnetic field tuning offered a noninva... |
41527151 | Increased caecal Intestinimonas abundance inhibits E. tenella gametogenesis via EtGFAT regulation and alleviates infection through immunity. | <h4>Background</h4>Chicken coccidiosis caused by Eimeria tenella (E. tenella) poses a major threat to global poultry production, with its tropism for the caecal microenvironment and dynamic interactions with the resident microbiota remaining incompletely understood. The caecal microbiota plays a critical role in host‒p... |
41526720 | Trade-offs in insect eye nanocoatings: implications for vision, ecology, and climate sensitivity. | Functional traits shape ecological niches, yet the interplay between nanoscale structural modifications, sexual dimorphism, and habitat range remains poorly understood. In fireflies, cuticular nanostructures that enhance bioluminescent signaling efficiency also impose ecological constraints. Anti-reflective nanocoating... |
41526646 | Development of a global screening system for detecting protein-protein interactions by luminescence complementation in fission yeast. | Deciphering protein-protein interactions (PPIs) is crucial for a comprehensive understanding of biological processes, yet current methodologies often provide incomplete interactome maps. Here, we present a sensitive bimolecular NanoBiT-based protein complementation assay platform for robust PPI detection in the fission... |
41526410 | Edible mayonnaise-like emulsion stabilized by rice bran protein fibril aggregation: effect of fibril aggregate structure. | This study investigated the impact of rice bran protein (RBP) fibril polymers (PFs) on the properties of mayonnaise-like emulsions. Using RBP with different structures during PFs formation, plant-based emulsions were prepared and evaluated for interfacial protein adsorption (AP%), water-holding capacity (WHC), rheologi... |
41526406 | Potent LeuBAT inhibitors designed in silico as next-generation duloxetine analogs for enhanced major depressive disorder treatment. | Major Depressive Disorder (MDD), a leading global health challenge, urgently requires advanced therapeutics to mitigate its widespread impact. In this study, a series of duloxetine (DLX) analogs were designed and evaluated using a comprehensive in silico workflow incorporating quantum chemical calculations, ADMET profi... |
41526377 | Sequence-encoded layered heteroleptic metalla-[2]catenanes for programmable supramolecular function. | Molecular information encoded within supramolecular frameworks offers a powerful paradigm for directing emergent function beyond the genetic code, but systematic investigations into alternative spatial configurations and their consequences remain scarce. Here we use metalla-[2]catenanes to probe sequence-function relat... |
41526354 | Propellane-free access to bicyclo[1.1.1]pentanes. | Bicyclo[1.1.1]pentane (BCP) has emerged over the past decade as a valuable three-dimensional bioisostere for benzene, attracting considerable interest in pharmaceutical research for its ability to improve drug-like properties. Although [1.1.1]propellane has traditionally served as the key precursor to mono- and 1,3- di... |
41526308 | Facile Label-Free Cytomembrane Reverse Coating Strategy via Membrane Carbohydrate-Lectin Self-Assembly for the Targeted Discovery of Natural Drug Candidates. | The ordered cytomembrane coating nanotechnologies have aroused increasing attention in various medical aspects, including drug screening. However, this ordered coating necessitates prior chemical or biological labeling of the cytomembrane, which threatens the preservation of the membrane protein bioactivity on nanopart... |
41526169 | Fluorescence Transduction of Liquid Crystal Ordering Transitions for Biosensing. | Liquid crystal (LC) ordering transitions are exquisitely sensitive to molecular interactions at aqueous interfaces and have long served as the basis for optical biosensors. However, the readout of these transitions has almost exclusively relied on polarized-light optical microscopy, which limits quantification and hind... |
41526008 | Potassium channels in vascular smooth muscle cells. | Vascular smooth muscle cells express several types of potassium (K<sup>+</sup>) channels that control physiological functions including contractility, migration, proliferation, and differentiation. Five primary classes of K<sup>+</sup> channel are present in vascular smooth muscle cells: large-conductance Ca<sup>2+</su... |
41525698 | Bridging the Hydration Barrier: Hydrogel Adhesives for Oral Hard-Soft Tissue Integration. | Oral hard-soft tissue repair present significant clinical challenges due to the highly dynamic, moist, microbially colonized, and inflammatory nature of the oral environment. Oral wounds from trauma, surgery, or disease cause discomfort and infection risk, demanding effective protection. The development of wet adhesive... |
41525414 | Lumpy skin disease virus protein LSDV122 impairs IFN-I receptor complex formation to evade host innate immunity. | Lumpy skin disease virus (LSDV) is a pathogenic poxvirus that causes systemic disease in cattle. Although LSDV encodes multiple proteins that are predicted to regulate host defense, the underlying mechanisms of its immune evasion strategies remain largely elusive. Here we identify the LSDV-encoded protein LSDV122 as an... |
41525309 | Targeted Supramolecular Senolytics by Enzyme-Responsive Disassembly and Intracellular Polymerization. | Recent evidence indicates that elimination of senescent cells from tissue can be a therapeutic approach to treat age-related disease, but selective targeting of senescent cells remains a challenge. Here, we report a dual-responsive self-assembly system selectively targeting senescent cells by responding to two hallmark... |
41525306 | Characterization of the heterogeneity in SARS-CoV-2 fitness dynamics via graph representation learning. | Understanding the heterogeneity of population-level viral fitness dynamics, which reflect the interplay between intrinsic viral properties and population immunity, is critical for pandemic preparedness. However, how these dynamics vary across diverse immune backgrounds and mutational landscapes remain poorly characteri... |
41525032 | Organic Phototransistor Photonic Synapses for Artificial Vision. | The von Neumann architecture faces significant limitations, including low transmission efficiency and high energy consumption, when handling large-scale data and unstructured problems. Benefiting from the inherent merits of optical signals including high bandwidth, near-zero Joule heating, fast transmission speed, and ... |
41524766 | Contact Electrification-Based Enantioselective Recognition of Chiral Amino Acids through Stereospecific Interfacial Electron Transfer. | Chirality lies at the heart of chemistry, governing the structure-function relationships of biomolecules, pharmaceuticals, and catalysts. However, rapid and label-free enantioselective analysis remains an enduring challenge due to the intrinsic similarity of enantiomers' physicochemical properties. Here, we report a co... |
41524628 | The C-terminus of infectious bursal disease virus VP3 encodes a predicted intrinsically disordered region, which promotes the formation of cytoplasmic puncta and modulates their physical properties. | The virus factories (VFs) of infectious bursal disease virus (IBDV) are biomolecular condensates formed through liquid-liquid phase separation (LLPS). A major component of the IBDV VF is the nonstructural protein VP3, but the molecular basis underlying VF formation remains poorly understood. Here, we demonstrate that V... |
41524565 | Selective Membrane Protein Enrichment Enables Defined Biomimetic Nanoparticles for Endothelial Targeting. | Nanoparticles offer a promising strategy for targeted drug delivery while reducing off-target toxicity. Biomimetic nanoparticles, which integrate native cell components, enhance biological compatibility but often suffer from poorly defined protein compositions that hinder reproducibility and clinical translation. Here,... |
41524478 | FAST-CRISPR: Fusogenic Association and Secured Transfection of CRISPR/Cas9 Ribonucleoproteins Using Lipid-Silica Hybrid Nanoparticles for Therapeutic Genome Editing. | Clinical translation of CRISPR/Cas9 therapeutics is challenged by inefficient cytosolic delivery and toxicity issues associated with viral vectors and nanoparticle-based carriers. To overcome these concerns, herein we report a lipid-silica hybrid nanoparticle platform for fusogenic association and secured transfection ... |
41524414 | Discovery, Isolation, and Bactericidal Activity of a Cyclotide from <i>Spigelia anthelmia</i> L. (Loganiaceae). | Cyclotides are plant-derived macrocyclic peptides stabilized by a cystine-knot motif, found in a limited number of angiosperm plants. This study reports the discovery of the cyclotide, Spat1, from <i>Spigelia anthelmia</i> (Loganiaceae), expanding the phylogenetic range of known cyclotide-producing plants. Spat1, a 30-... |
41524401 | A VLP-based mRNA vaccine elicits potent humoral and cellular immunity against Oropouche virus. | Oropouche virus (OROV) is reemerging in the Americas, along with a growing threat to global public health. Recent outbreaks have witnessed the first reported fatalities, vertical transmissions, and intercontinental importations of OROV, underscoring its expanding risk. Despite this, no vaccines or specific therapeutics... |
41524409 | Engineering a mouse-adapted SADS-CoV and establishing a neonatal mouse model to study its infection. | Swine acute diarrhea syndrome coronavirus (SADS-CoV) is an emerging bat-origin alphacoronavirus causing severe disease in neonatal piglets, with significant economic losses to the swine industry. The virus exhibits a broad species tropism, infecting cells derived from pigs, humans, and mice, highlighting its potential ... |
41524410 | Biology of novel LpxC inhibitors for <i>Neisseria gonorrhoeae</i> informs strategy for therapeutic innovation. | Historically, LpxC inhibitors, which target the UDP-3-<i>O-(R-</i>3-hydroxymyristoyl)-<i>N-</i>acetylglucosamine deacetylase catalyzing the rate-limiting step in lipid A biosynthesis, have a hydroxamate zinc-chelating head group that targets the active site and can participate in non-specific metal chelation. We synthe... |
41524404 | Development and evaluation of novel zein-based artemisinin sustained-release formulation for treating drug-resistant malaria. | Artemisinin antimalarial drugs initially exhibited remarkable efficacy against <i>Plasmodium falciparum</i>. However, their poor solubility and low bioavailability necessitate high doses and lead to an extremely short <i>in vivo</i> half-life. These limitations not only drive the emergence of drug-resistant <i>Plasmodi... |
41524325 | Machine Learning-Assisted DNA Origami Shape Sorting Using Fingerprinting Nanosensors and Feature Engineering. | Reconfigurable DNA nanostructures have emerged as a promising research area with applications in drug delivery, molecular computing, biosensing, and stimuli-responsive soft nanomaterials. While significant progress has been made in creating novel DNA nanostructures and exploring their applications, comparatively little... |
41524271 | WRKY Transcription Factors: Integral Regulators of Defence Responses to Biotic Stress in Crops. | Crops are continually challenged by biotic stresses, including fungal, bacterial and viral pathogens and insect pests, which cause substantial yield and quality losses worldwide. WRKY transcription factors constitute a plant-specific and functionally diverse family that is central to immune regulation. Recent advances ... |
41524227 | Antibody-Empowered Nanomedicine for Precise Biomedical Applications. | The advancement of nanotechnology has positioned nanomedicine as powerful tools for disease diagnosis and treatment. However, the clinical efficacy of conventional nanomedicine is often limited by its passive targeting strategies and limited range of therapeutic mechanisms, leading to suboptimal accumulation at disease... |
41524209 | Circularly Polarized Long-Persistent and Photostimulated Luminescence Enabled through Förster Resonance Energy Transfer and Upconversion Strategies. | Circularly polarized luminescence (CPL) has attracted significant attention for applications in displays, data encryption, anti-counterfeiting, and bioimaging. However, extending the emission lifetime beyond the second timescale remains a challenge. Here, we report circularly polarized long-persistent luminescence (CP-... |
41524177 | Wide Band Gap Boron Nitride Nanodots-Incorporated Polyetherimide Dielectrics for High-Temperature Dielectric Energy Storage. | With the ongoing trend toward miniaturization in electronic devices and the concomitant increase in power density, the operational requirements for dielectric polymer films have extended beyond conventional room-temperature conditions. In this study, low mass fraction boron nitride nanodots (BNNDs) were incorporated in... |
41524128 | 830 nm-Excitable Triplet-Triplet Annihilation Upconversion Achieved by a Selenium-Integrated Heptamethine Cyanine Sensitizer. | We demonstrated that the selenium-integrated heptamethine cyanine acts as a near-infrared photosensitizer when combined with rubrene (annihilator), achieving triplet-triplet annihilation upconversion (TTA-UC) with 830 nm excitation and 557 nm emission and an upconversion quantum yield of up to 1.0% (out of 50%). Compar... |
41521919 | Metal-Coordinated Assembly of Collagen-like Proteins into Microflorettes. | Collagen is the most abundant protein in the extracellular matrix. Owing to its exceptional biocompatibility, collagen-based materials are widely utilized in biomedicine. Genetic engineering enables the production of collagen derivatives tailored to biomaterial applications. Herein, we engineered a stimulus-responsive ... |
41521376 | Photo-Assisted Flexible Energy Storage Devices: Progress, Challenges, and Future Prospects. | Photo-assisted flexible energy storage devices, combining photoelectric conversion and electrochemical energy storage, emerge as an innovative solution for sustainable energy systems. This review comprehensively summarizes recent advances in photo-assisted flexible energy storage technology, covering material design, w... |
41521377 | Dynamic Radiative Cooling: Mechanisms, Strategies, and Applications for Smart Thermal Management. | As an emerging thermal management strategy, dynamic radiative cooling (DRC) technology enables dynamic modulation of spectral radiation properties under varying environmental conditions through the directional design of material spectral characteristics. However, a comprehensive review of the basic physical mechanisms ... |
41521364 | Bright Sparks of Single-Atom and Nano-Islands in Catalysis: Breaking Activity-Stability Trade-Off. | Single-atom catalysts (SACs) are among the most cutting-edge catalysts in the multiphase catalysis track due to their unique geometrical and electronic properties, the highest atom utilization efficiency, and uniform active sites. SACs have been facing an unresolved problem in practical applications: the opposing contr... |
41521254 | Rational Design and Functionalization of Melt Electrowritten 4D Scaffolds for Biomedical Applications. | Melt electrowriting (MEW) enables the precise deposition of polymeric fibers at micro-/nanoscale, allowing for the fabrication of 3D biomimetic scaffolds. By incorporating stimuli-responsive polymers and/or functional fillers, MEW-based 4D printing creates scaffolds capable of undergoing controlled, reversible shape tr... |
41521175 | Electric field stimulation-responsive hydrogels for bone regeneration: from mechanisms to applications. | The continuous extension of human life expectancy and the global trend of population aging have contributed to a marked increase in the incidence of musculoskeletal diseases, with fractures and osteoporosis being prominent examples. Consequently, promoting bone regeneration is a crucial medical challenge that demands i... |
41504338 | Virulence and transmission characteristic of H3N8 avian influenza virus circulating in chickens in China. | Influenza H3N8 viruses have been frequently isolated from chicken farms. However, comprehensive characterization of their virological properties, molecular evolution, virulence, and risk of spillover into mammals remains limited. In particular, little attention has been given to the transmission efficiency of H3N8 avia... |
41427789 | The deletion of the EP402R and MGF505/360 genes attenuates a genotype I/II recombinant ASFV but fails to confer complete protection against homologous or genotype II challenge in pigs. | African swine fever (ASF), a pig disease caused by ASFV, is highly contagious and often lethal. The recent emergence of novel ASFV with I/II genomic recombination has posed significant challenges to global ASF prevention and control. In this study, we used the Chinese I/II genomic recombinant virulent strain ASFV-HN100... |
41311111 | Supramolecular dyes: advancing precision medicine through molecular engineering. | Precision medicine is aimed at achieving a more personalized approach tailored to individual characteristics and urgently requires the development of precise diagnostic and therapeutic methods. Small-molecule dyes play indispensable roles in medical imaging and surgery procedures, attracting significant attention regar... |
41810463 | Porous Baicalin-Fe(III) ICP@Propofol nanocomposites for enhanced anesthetic efficacy and reduced toxicity via neuroprotection and ultrasound assistance. | To enhance the anesthetic efficacy of propofol while mitigating its systemic toxicity and irreversible developmental neurotoxicity, we developed a strategy leveraging the neuroprotective effects of baicalin in combination with propofol anesthesia via baicalin-based nanocomposites. High propofol-loaded porous Baicalin-F... |
41626488 | Molecular Dynamics and Experimental Validation of Natural Products from Chuanxiong Rhizoma as VEGFR2 Inhibitors for nAMD Therapy. | Age-related macular degeneration (AMD) is a leading cause of blindness among the elderly worldwide. Neovascular AMD (nAMD) is a significant subtype of AMD, responsible for the blindness of over 90% of patients with AMD. The hallmark of nAMD is choroidal angiogenesis dysregulation, a condition that can result in severe ... |
41599724 | Evaluation of Daughter Radionuclide Release from the <sup>103</sup>Pd/<sup>103m</sup>Rh In Vivo Generator for Targeted Auger Therapy. | <b>Background/Objectives</b>: The <sup>103</sup>Pd/<sup>103m</sup>Rh in vivo generator represents a promising Auger electron-emitting system, in which both parent and daughter radionuclides emit predominantly Auger electrons with minimal accompanying radiation. This study investigates the release dynamics of daughter r... |
41599294 | Functional Food-Derived Urolithins: Molecular Mechanisms, Health Effects, and Interactomics with Proteins and Extracellular Vesicles. | Over the past decade, research on urolithins has expanded significantly due to their role as mediators between polyphenol-rich diets and human health. Understanding the relationships between ellagitannin intake, gut microbiota composition, and urolithin production is essential for evaluating their biological effects an... |
41599293 | Multifaceted Attack Networks of Artemisinin in Reversing Chemoresistance in Colorectal Cancer. | Chemotherapy resistance in colorectal cancer (CRC) represents a critical clinical challenge leading to treatment failure and poor patient prognosis. Artemisinin is a natural product isolated from Artemisia annua, and its clinically relevant derivatives include dihydroartemisinin (DHA) and artesunate. Beyond their estab... |
41599202 | CRISPR-Cas-Mediated Reprogramming Strategies to Overcome Antimicrobial Resistance. | Antimicrobial resistance (AMR) is escalating worldwide, posing a serious threat to global public health by driving infections that are no longer treatable with conventional antibiotics. CRISPR-Cas technology offers a programmable and highly specific therapeutic alternative by directly targeting the genetic determinants... |
41596865 | Construction of N/S CQDs@Fe-TCPP Nanocatalyst-Induced Electrochemical Sensors for Rapid and Sensitive Detection of Enrofloxacin Residues in Milk. | Given the potential hazards of enrofloxacin (ENR) residues to human health, establishing an accurate, rapid, and stable detection method is of importance. To enable the direct detection of ENR, an electrochemical sensor was constructed in this study. N- and S-doped carbon quantum dots (CQDs) with peroxidase-like activi... |
41596859 | Print, Eat, Heal: Unravelling the Potential of Bioactives in 3D Food Technology. | 3D-printed food (3DPF) is on the rise, enabling the development of new food products. Current applications in this domain led to the replication of meat analogs, protein-enriched products, and dietary solutions tailored to address nuanced health necessities. Central to the functional versatility of 3DPF is its capacity... |
41596391 | Synthesis, Antimicrobial Evaluation, and Molecular Docking Analysis of Novel Schiff Bases Derived from Isatoic Anhydride and Salicylaldehyde. | Schiff bases are bioactive compounds that have been synthesized by many researchers in recent years. They may also exhibit strong antimicrobial activities against various pathogenic microorganisms in both medicine and veterinary applications. The synthesis of new Schiff base-derived compounds remains of interest due to... |
41596387 | From Microbes to Medicine: Targeting Metalloprotein Pathways for Innovative Antibacterial Strategies. | Antibiotic resistance is an escalating global health problem that calls for new types of treatments beyond standard antibiotics. This review examines how targeting bacterial metalloproteins, especially those involved in siderophore-driven iron uptake and manganese-based oxidative defense, could lead to more selective a... |
41590464 | Antifungal Potential of <i>Diaporthe</i> sp. Endophytes from Antillean Avocado Against <i>Fusarium</i> spp.: From Organic Extracts to In Silico Chitin Synthase Inhibition. | Fungal endophytes have emerged as a promising source of bioactive compounds with potent antifungal properties for plant disease management. This study aimed to isolate and characterize fungal endophytes from Antillean avocado (<i>Persea americana</i> var. <i>americana</i>) trees in the Colombian Caribbean, capable of p... |
41558077 | Positive effects of bile acids alleviating heat stress in laying hens by enhancing immunity via metabolome and transcriptome integration. | This experiment was aimed to investigate the effects of dietary supplementation with porcine-derived bile acids (BAs) on production performance, immune function, serum metabolome, and liver transcriptome in heat-stressed laying hens. A total of 400 55-week-old Jingfen No.3 laying hens with similar body weight and layin... |
41534175 | Real-time fluorescence diagnosis guided glucose-triggered chemodynamic therapy for diabetic wounds using covalent organic framework@metal-organic framework cascade nanoreactor. | Diabetic wound management remains a major clinical challenge due to the difficulty in achieving precise therapeutic modulation and the lack of reliable approaches for real-time identification of wound pathological stages. To address this, we report the development of a novel covalent organic frameworks@metal-organic fr... |
41532007 | Decoy Receptors in Autoimmunity: Molecular Guardians and Pathogenic Players in Immune Dysregulation. | Autoimmune disorders encompass a varied range of diseases in which the immune system mistakenly targets and attacks the body's own tissues. The causes of the conditions are unknown. It is presumed that various genetic, environmental, and immune factors all play a part. Nowadays, therapies concentrate mainly on anti-inf... |
41531488 | Evolution of H5N1 Cross-Species Transmission: Adaptive Mutations Driving Avian-to-Human Infection. | First detected in poultry in China in 1996, the H5N1 avian influenza virus has evolved into a significant global public health hazard, primarily owing to its high pathogenicity and potential for interspecies transmission. While primarily affecting avian species, H5N1 has repeatedly breached species barriers, infecting ... |
41529799 | Lignin based regenerated cellulose guided supramolecular reassembly from waste MDF into nitrogen-doped hierarchical carbons for sustainable energy storage. | The efficient and sustainable conversion of lignocellulosic biomass into carbon materials remains a significant challenge due to weak interfacial interactions and poor pore structure control. Herein, a supramolecular deconstruction-reconstruction strategy coupled with defect engineering is reported for the upcycling of... |
41529752 | Unprecedentedly tough, strong, water-resistant, and multifunctional lignin-based resin adhesives inspired by loose connective tissue, plant cell walls, and mussel foot proteins. | Utilizing lignin as a complete substitute for petroleum-derived phenol to synthesize non-toxic lignin-based resin adhesives with bio-based aldehydes holds substantial significance for advancing sustainable development in the wood-based panel industry. Nevertheless, the poor bonding strength, toughness, and water resist... |
41529750 | Marine-derived polysaccharides enhance the drug delivery mechanism in the management of ocular diseases: A review. | Ocular drug delivery remains significantly challenging due to complex anatomical and physiological barriers, poor bioavailability, and inefficient drug absorption. These limitations highlight the requirement for advanced delivery systems to overcome the ocular barrier and enable efficacious therapeutic outcomes. This r... |
41529728 | Amelogenin proteolysis orchestrates functional amyloid pathways in enamel development. | Amelogenin, the most abundant protein in developing enamel, self-assembles into supramolecular structures that serve as templates for apatite growth. Recent studies revealed that amelogenin nanoribbons exhibit hallmark features of functional amyloids, yet the molecular mechanisms governing their formation remain incomp... |
41521695 | Interfacial Electron Modulation in a Mixed-Valence Cu(II)/Cu(III) Energetic MOF for Dual-Functional Catalysis: Enhanced Ammonium Perchlorate Thermolysis and Efficient CO<sub>2</sub> Electroreduction. | The development of multifunctional catalytic platforms that reconcile high energy density with environmental sustainability presents a significant challenge in materials science. Herein, we report a rare mixed-valence Cu(II)/Cu(III) energetic metal-organic framework (EMOF), {[Cu(II)Cu(III)<sub>2</sub>(HBTT)(BTT)Cl<sub>... |
41521586 | Nickel(II) Complexes Derived from Schiff Base Ligands Designed as Electrode Materials in Asymmetric Supercapacitor Coin Cells for Enhanced Energy Storage Performance. | In this study, three nickel(II)-based Schiff base complexes, derived from the condensation of 2-hydroxybenzaldehyde with 2-bromo-4-chloroaniline (C1), 2-bromo-4-methylaniline (C2), and 2-iodo-4-nitroaniline (C3), were synthesized using a one-pot in situ reaction strategy without isolating the corresponding ligands. The... |
41521555 | Discovery of Fragment-Based Inhibitors of SARS-CoV-2 PL<sup>Pro</sup>. | SARS-CoV-2 papain-like protease (PL<sup>Pro</sup>) plays a key role in viral replication and the host immune response and is a promising target for developing new antiviral treatments. We previously reported a fragment-based screen to identify hits that bind to SARS-CoV-2 PL<sup>Pro</sup>. Here, we describe the discove... |
41521483 | Achieving Photo-Activated Circularly Polarized Room Temperature Phosphorescence from Natural Biopolymers. | Developing sustainable photo-activated circularly polarized room temperature phosphorescent (CPRTP) materials is attractive for optoelectronic applications while are difficult to achieve. Here, we report the first example of bio-based photo-activated CPRTP material by anchoring arylboronic acids into hydroxypropyl cell... |
41521467 | Vapor-Assisted Catalysis Enables Precise Construction of MOF-Derived Hierarchical Carbon Nanoarrays for High-Performance Supercapacitors. | The synthesis of MOF-derived carbons with high surface area and conductivity is challenged by a fundamental trade-off between architectural preservation and catalytic graphitization. Here, we introduce a spatially decoupled, vapor-assisted pyrolysis strategy where a Co-MOF precursor array is physically separated from a... |
41521476 | Self-Powered Organic Photoelectrochemical Transistor Detection. | Organic photoelectrochemical transistor (OPECT) holds significant promise for bioanalysis, but its application is constrained by dual-voltage requirements. Here, we constructed a Bi-MOF@CdS@Au/DNA-gated self-powered OPECT for enrofloxacin (ENR) detection by integrating a solar cell between the source and drain electrod... |
41521460 | GbWAKL20 Phosphorylates GbNFYB8 to Modulate Verticillium Wilt Resistance in Cotton. | Verticillium wilt (VW), caused by Verticillium dahliae (Vd), is a major threat to cotton production worldwide. Wall-associated receptor-like kinases (WAKLs) are critical for plant-environment communication and fungal pathogen resistance, yet their regulatory mechanisms in cotton remain unclear. Through genomic and tran... |
41521330 | Crosstalk between ferroptosis and extracellular vesicles in cancer: from interaction to clinical application. | Cancer continues to pose a significant issue to public health. Despite the considerable advancements in popular therapies such as surgery, radiation, chemotherapy, targeted therapy, and immunotherapy, a substantial number of patients continue to suffer from cancer due to severe treatment resistance. As a result, it is ... |
41521170 | Affinity of drug candidates binding to SARS-CoV-2 PLpro assessed using a generalized-ensemble method. | To establish a procedure for screening compounds that inhibit ligand-receptor binding, we employed a multidimensional virtual-system coupled molecular dynamics (mD-VcMD), a generalized ensemble method recently developed by our group. In this approach, each compound is initially placed far from the receptor. Both recept... |
41521070 | Vascularised Brain Organoids: Engineering Strategies and Neurobiological Applications. | Brain organoids have become an essential platform for studying human neural development and neurological disorders. Yet, one major limitation of conventional brain organoids is their lack of vascular structures. This deficiency restricts organoid size, contributes to necrotic core formation, and hampers their functiona... |
41520320 | Fluorine-18-labeled PET radiotracers for imaging the macrophage colony-stimulating factor 1 receptor (CSF1R). | <h4>Background</h4>Positron emission tomography is a useful tool for quantitative imaging of neuroinflammation in human subjects; however, more suitable radiotracers are sought. One of the promising targets for imaging neuroinflammation is macrophage colony-stimulating factor 1 receptor (CSF1R) because of its expressio... |
41520285 | A Novel Biosensor for Ferrous Iron Developed via CoBiSe: A Computational Method for Rapid Biosensor Design. | Genetically encoded biosensors enable the monitoring of metabolite dynamics in living organisms. We present CoBiSe, a <u>co</u>mputational <u>bi</u>o<u>se</u>nsor design approach using Constraint Network Analysis to identify optimal insertion sites for reporter modules in molecular recognition elements (MREs). Applied ... |
41519916 | Nimbolide ameliorates ARDS and ulcerative colitis by disrupting NLRP3 inflammasome activation. | Excessive activation of the NLRP3 inflammasome drives the pathogenesis of diverse inflammatory diseases. However, the clinical application of NLRP3 inflammasome inhibitors remains a significant challenge. Here, we screen a natural product library of 126 compounds and identify Nimbolide (NIM), a triterpenoid from Azadir... |
41660273 | Self-assembly of plant-derived bioactive nanostructures in traditional Chinese medicine. | Traditional Chinese medicine (TCM) relies on plant-derived compounds to achieve therapeutic effects through multi-component and multi-level regulation. Increasing evidence indicates that many bioactive constituents in TCM can spontaneously self-assemble into nanoscale aggregates under aqueous or physiological condition... |
41626447 | Optical Detection of Water Adulteration in Ethanol Using PCPDTBT-Conjugated Polymer Nanoparticles. | The detection of water adulteration in ethanol biofuels is a persistent challenge due to ethanol's high affinity for water and the limitations of conventional analytical methods. In this study, we present an innovative optical sensing strategy using conjugated polymer nanoparticles (CPNs) composed of poly-[2,6-(4,4-bis... |
41600993 | Donor Plasmid Optimization Enhances Expression of Feline Parvovirus VP2 Protein in the Baculovirus Expression Vector System. | <h4>Background</h4>Feline panleukopenia virus (FPV) causes acute and frequently fatal disease in cats, underscoring the urgent need for safe, rapidly effective, and scalable vaccines. While virus-like particle (VLP) vaccines are inherently safe and immunogenic, their development is constrained by low yields of recombin... |
41599722 | The Allosteric Regulation of the DNA-Binding Domain of p53 by the Intrinsically Disordered C-Terminal Domain. | <b>Background</b>: Intrinsically disordered regions (IDRs) within proteins often act as pivotal linkage units for the interaction of functional domains. The p53 tumor suppressor protein contains intrinsically disordered N-terminal and C-terminal domains (NTD and CTD), playing crucial regulatory roles in cellular proces... |
41599492 | Biopolymer-Based Active and Intelligent Food Packaging: Recent Advances in Materials, Technologies, and Applications. | The food packaging industry is undergoing a paradigm shift from conventional petroleum-based materials toward sustainable biopolymer-based alternatives that offer enhanced functionality beyond mere containment and protection. This comprehensive review examines recent advances in the development of active and intelligen... |
41599489 | Polymer Composites in Additive Manufacturing: Current Technologies, Applications, and Emerging Trends. | Polymer composites have opened a novel innovation phase in additive manufacturing (AM), and now lightweight, high-strength, and geometrical advanced components with tailored functionalities can be produced. The present study introduces advances in polymer composite materials and their integration into AM processes, par... |
41599288 | Synthesis of Hydroxyaromatic Carboxylic Acids via Homogeneous Kolbe-Schmitt Carboxylation of Phenoxides. | Homogeneous Kolbe-Schmitt carboxylation of phenoxides offers a mild and effective alternative to the classical high-temperature solid-phase Kolbe-Schmitt reaction. To develop this into a practical synthetic approach, we investigated several fundamental dependencies, particularly the impact of cations (Na, K, Li, Cs, an... |
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