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41599290 | Peptide-Functionalized Iron Oxide Nanoparticles for Cancer Therapy: Targeting Strategies, Mechanisms, and Translational Opportunities. | Therapeutic peptides have emerged as promising tools in oncology due to their high specificity, favorable safety profile, and capacity to target molecular hallmarks of cancer. Their clinical translation, however, remains limited by poor stability, rapid proteolytic degradation, and inefficient biodistribution. Iron oxi... |
41599200 | Protection Against <i>Toxoplasma gondii</i> Lethal ME49 Challenge Induced by Influenza Virus-like Particles Containing Dense Granule Protein 14. | <b>Background/Objectives</b>: <i>Toxoplasma gondii</i> (<i>T. gondii</i>) dense granule antigen 14 (GRA14) is a parasitophorous vacuole membrane protein that plays a critical role in the development of chronic-stage cysts. However, its potential as a vaccine antigen and long-term immunity have not been evaluated using ... |
41599197 | Potentiation of the Pharmacological Effects of an <i>Aristolochia clematitis</i> L. Extract by Loading into Liposomes Facilitating Release to HaCaT Cells. | <b>Background:</b><i>Aristolochia clematitis</i> L. (AC), a plant with diverse traditional uses, has gained increasing scientific interest due to its rich content of bioactive compounds such as flavonoids and polyphenols. However, its systemic use is limited by the presence of aristolochic acids, which are known for th... |
41598502 | Are the Results of Late Heart Re-Transplantation Influenced by the Time Interval from Primary Transplantation? | <b>Background</b>: Heart re-transplantation represents an effective option in selected patients with graft failure. Although the results of heart re-transplantation have improved in recent years, little is known about the outcomes in patients requiring late (>1 year) re-transplantation or about the effects of prolonged... |
41598002 | Polymer Prolate Spheroids, Ellipsoids, and Their Assemblies at Interfaces-Current Status and Perspectives. | Most nanoparticles and microparticles used as carriers of bioactive compounds are spherical in shape. Such particles are the easiest to obtain, as many processes spontaneously minimize the surface energy of the objects produced. However, in recent years, scientists have turned their attention to non-spherical particles... |
41597678 | Selective Budding of SARS-CoV-Like Particles from Glycolipid-Enriched Membrane Lipid Rafts and Host Gene Modulation. | Severe acute respiratory syndrome coronavirus (SARS-CoV) assembles and buds from the Golgi apparatus or the ER membrane, but the specific membrane microdomains utilized during this process remain underexplored. Here, we show that co-expression of the SARS-CoV structural proteins S, M, and N in HEK-293T cells is suffici... |
41596856 | Influence of pH and Heat Treatment on the Physicochemical, Interfacial, and Emulsifying Properties of Hemp Seed Protein Dispersions. | This study reports the effect of pH (2, 7, 10) and heat treatment (80 °C for 30 min) on the oil-water (o/w) interfacial behavior of hemp seed protein isolate (HPI) aqueous dispersions. The physicochemical, interfacial adsorption, rheology, and emulsifying properties of protein dispersions were evaluated. HPI dispersion... |
41596370 | Application of Orthoflavivirus Pseudovirus Technology in Antiviral Research. | Arthropod-borne orthoflaviviruses, including dengue, Zika, Japanese encephalitis, yellow fever and West Nile viruses, pose a significant global public health threat, causing hundreds of millions of infections annually with severe clinical symptoms. However, the lack of effective vaccines and antiviral drugs, coupled wi... |
41591181 | Advances in Clostridial Neurotoxins: Passage of the Intestinal Barrier and Targeting of Specific Neuronal Cells. | Clostridial neurotoxins, botulinum neurotoxins (BoNTs), and tetanus neurotoxin (TeNT) are potent toxins responsible for severe diseases, botulism and tetanus, respectively. BoNTs associate with non-toxic proteins (non-toxic non-hemagglutinin, hemagglutinins, and OrfXs), which protect BoNTs against acidic pH and proteas... |
41590305 | Functionalized Metal-Organic Frameworks Integrated with Plasmonic Nanoparticles: From Synthesis to Applications. | Plasmonic nanoparticles (NPs) exhibit exceptional optical and electromagnetic (EM) properties that are, however, confined to their near-field region, limiting effective interactions with non-adsorbed species. Metal-organic frameworks (MOFs), renowned for their high surface area and tunable pores, provide an ideal compl... |
41590306 | Metallic Flexible NiTi Wire Microcrack Transducer for Label-Free Impedimetric Sensing of <i>Escherichia coli</i>. | Flexible biosensors offer rapid and low-cost diagnostics but are often limited by the mechanical and electrochemical instability of polymer-based designs in biological media. Here, we introduce a metallic flexible microcrack transducer that exploits the intrinsic deformability of superelastic nickel-titanium (NiTi) for... |
41585437 | Infection protection, immune regulation and epithelial regeneration trifunctional hydrogel for treatment of burn wounds. | Severe burn wounds are characterized by epithelial disruption and persistent inflammation, which impede re-epithelialization and heighten susceptibility to bacterial colonization and invasion, thereby posing serious clinical risks. To address these challenges, we developed an innovative smart hydrogel (Ag-IMP-U@Cur), i... |
41584077 | Multimodal profiling of CAR T cells against glioblastoma using a microengineered 3D tumor-on-a-chip model. | Immunotherapies such as chimeric antigen receptor (CAR) T cells have shown promising outcomes in hematological cancer but face challenges in targeting solid tumors like glioblastoma (GBM). Advancing this therapy for GBM has been hindered by the lack of preclinical tools that accurately model the complex interplay betwe... |
41585441 | Targeting IBD treatment: smart drug delivery systems for oral administration. | Inflammatory bowel disease is a global widespread condition that significantly reduces patients' quality of life. Conventional oral therapies suffer from poor site-specific targeting, systemic absorption, and limited drug stability, leading to reduced efficacy and adverse effects. Smart drug delivery systems have emerg... |
41584086 | Human 3D liver spheroids support productive infection of a novel tick-borne phenuivirus. | The identification of novel tick-borne viruses, such as Mukawa virus (MKWV), underscores a growing need to assess their potential public health risks. In this study, we isolated the MKWV strain HLJ1 from <i>Ixodes persulcatus</i> ticks. While this initial isolate demonstrated limited replication in mammalian cell lines... |
41567986 | Prototissues: Assembly strategies, collective behaviors, and emerging applications. | Recent advances in bottom-up synthetic biology have significantly expanded the ability to construct artificial life systems. While most efforts focus on building protocells, many biomimetic functions arise only when multiple units operate collectively. Prototissues, formed from interconnected protocell assemblies, prov... |
41534177 | Bonding-site-locked interfacial engineering in NH<sub>2</sub>-MIL-125(Ti)/copper chlorophyllin S-scheme enabling spatially matched charge transfer for CO<sub>2</sub> reduction. | Interfacial electronic coupling critically determines the performance of S-scheme photocatalysts, yet spatial mismatching between anchoring sites and charge-accumulation regions often limits charge transfer efficiency. Herein, a bonding-site-locked interfacial engineering strategy is proposed to construct an S-scheme h... |
41529627 | Single-atom Cu nanozyme anchored on carbon nitride with enhanced peroxidase-like activity for colorimetric detection of foodborne pathogens. | Nanozyme-based colorimetric biosensors for foodborne pathogens are promising, but their sensitivity is often limited by the insufficient catalytic performance of nanozyme probes. Herein, a copper single-atom nanozyme anchored on carbon nitride (Cu-SA-CN), with a Cu loading of 24.1 wt%, was fabricated via a novel supram... |
41525982 | Enhanced biodegradation of sticky deposits through cutinase-lipase synergy in designer cellulosomes. | Sticky deposits hinder the recycling of waste paper by causing equipment clogging and poor paper quality. Enzymatic degradation is constrained by poor enzyme stability and limited degradation capacity. Herein, Humicola insolens cutinase and Archeoglobus fulgidus carboxylesterase, were selected to construct a cellulosom... |
41525845 | Effect of pH on small-molecule inhibitor binding to influenza virus hemagglutinin. | Influenza A viruses (IAVs) impose a tremendous socioeconomic burden, and the mainstay preventative strategy of using vaccines faces challenges related to annual reformulation and variable efficacy (30-70%). The occurrence of antiviral resistance to the current Food and Drug Administration-approved anti-influenza drugs ... |
41525829 | Temperature-tuned Co-ZIF-67@Fe-MIL(101) derived catalysts for advanced peroxymonosulfate activation in enrofloxacin removal from water. | Binary MOF@MOF structure offers enhanced porosity, active site density, and structural stability in term of using mono MOFs. In this study, a novel bimetallic composite based on binary MOFs structure, Co-ZIF-67@Fe-MIL(101), was synthesized and subsequently subjected to thermal treatment at 500 °C, resulting in a carbon... |
41525804 | The clinical potential and limitations of metal-organic frameworks (MOFs) in dentistry. | Nanoparticles (NPs) are intentionally incorporated into dental products to enhance material quality. Recently, metal-organic framework (MOF) NPs have attracted significant attention owing to their unique characteristics absent in their larger-scale counterparts. These properties make MOFs suitable for various functiona... |
41522489 | Recent Advances in Lateral Flow Immunoassay for Rapid Diagnosis of Viral Diseases. | Viral diseases are a major threat to human and animal health, as illustrated by recent pandemics like COVID-19 and African swine fever (ASF). Timely, accurate detection of viral infections is critical for effective disease control. Among diverse diagnostic techniques, lateral flow immunoassay (LFIA) has become a widely... |
41520536 | Delineating degradation of polyethylene microplastics by mangrove-derived microbes: Enzymatic pathways and intermediate identification. | The accumulation of polyethylene microplastics (PE-MPs) in marine and coastal environments, particularly mangrove ecosystems, poses significant environmental challenges. To address this, we investigated the bioremediation potential of two bacterial strains, Lysobacter sp. (MAS-1) and Nitratireductor kimnyeongensis (MAS... |
41520441 | Molecular simulations of the tunable pore structure models elucidate the adsorption of sulfamethoxazole on biochar. | Biochar is an environmentally friendly adsorption material that can effectively adsorb sulfamethoxazole (SMX) in water. However, the relationship between the pore structure characteristics of biochar and the SMX adsorption process remains unclear. In this study, molecular dynamics (MD) simulations combined with complem... |
41520085 | Enzymatic galactosylation of phenolic compounds by permeabilized cells of Pantoea anthophila. | The permeabilized cells of two Pantoea anthophila strains (BI 55.2 and BI 69.1) were evaluated for galactosylation of phenolic compounds with different molecular structure (gallic acid, caffeic acid, catechin, phlorizin, puerarin and mangiferin), the highest conversion was observed on puerarin (36.5 ± 8.4 and 53.3 ± 7.... |
41519933 | The dental implant surface: a review of the past, present and future. | <h4>Purpose</h4>The review provides an in-depth analysis of various factors that affect the long-term success of implants and scrutinizes all available techniques for dental implant modifications, along with their advantages and limitations. Along with established and proposed strategies, newer trends such as responsiv... |
41519891 | A self-assembled molecule directs ordered α-FAPbI<sub>3</sub> for n-i-p perovskite solar cells. | Formamidinium lead iodide (FAPbI<sub>3</sub>) perovskite is a leading candidate for high-efficiency solar cells, but its application is hindered by the kinetic instability of its α-phase crystallization. Here, a highly effective strategy for directing the ordered crystallization of α-FAPbI<sub>3</sub> in the n-i-p arch... |
41519889 | Structure of SHOC2-KRAS-PP1C complex reveals RAS isoform-specific determinants and insights into targeting complex assembly by RAS inhibitors. | RAF activation is essential for MAPK signaling and is mediated by RAS binding and the dephosphorylation of a conserved phosphoserine by the SHOC2-RAS-PP1C complex. MRAS forms a high-affinity SHOC2-MRAS-PP1C (SMP) complex, while canonical RAS isoforms (KRAS, HRAS, NRAS) form analogous but lower-affinity assemblies. Yet,... |
41519830 | Mixing protocols determine liquid-liquid phase separation dynamics in polyelectrolyte complex coacervation. | Polyelectrolyte complex coacervation underpins many critical biological processes, yet how different initial mixing protocols determine its liquid-liquid phase separation (LLPS) dynamics remains unclear. Using molecular dynamics simulations, we show that when polycations and polyanions are initially randomly mixed, coa... |
41519798 | Preparation and in vitro sustained release performance of thermosensitive gel microsphere composite loaded with Anti-Tuberculosis drug PaMZ/BMP-2. | <h4>Background</h4>To meet the needs of local treatment for spinal tuberculosis, this study developed a thermosensitive gel microsphere composite with both anti-tuberculosis and osteogenesis-promoting functions for efficient drug sustained release. The composite consists of anti-tuberculosis drugs (Pretomanid, Pa-824; ... |
41519693 | PfTALE5 Acts as a hub for multi-stress resilience: a genome-wide study of the TALE family in Paulownia fortunei. | <h4>Background</h4>The Three-Amino-Acid-Loop-Extension (TALE) transcription factors are key regulators of plant development and stress responses. However, a systematic study of the TALE gene family in Paulownia fortunei has not been reported to date.<h4>Results</h4>Here, we conducted the first genome-wide analysis and ... |
41518665 | Torsional Flexibility Tuning of Hexa-Carboxylate Ligands to Unlock Distinct Topological Access to Zirconium Metal-Organic Frameworks. | Zirconium-based metal-organic frameworks (Zr-MOFs) exhibit remarkable structural diversity and functionality. However, uncovering new topological types within this family remains a considerable challenge today. Herein, we report two new hexa-topic ligands designed through the introduction of torsional flexibility, whic... |
41518645 | A cucurbitane-type triterpene from <i>Sorbaria kirilowii</i> (Regel) Maxim. and its PDE1 inhibitory activity. | Sorbariakirine A (<b>1</b>), a cucurbitane-type triterpene, along with nine known compounds (<b>2</b>-<b>10</b>), were isolated from the aerial parts (stems and leaves) of <i>Sorbaria kirilowii</i> (Regel) Maxim. The structure of compound <b>1</b> was determined through comprehensive spectroscopic analysis (IR, MS, 1D/... |
41518525 | The emerging role of cholesterol metabolism in gynecologic cancer development and therapy. | The significance of cholesterol metabolism in cancer is a topic of renewed interest. Cholesterol is an essential factor for mammal cells, for it is not only involved in constituting the cell membrane, but also serves as a precursor to steroid hormones and bile acids. Numerous studies have provided increasing evidence o... |
41518487 | The ethyl acetate extract from Trichoderma viride fermentation acts by downregulating the leukocyte transendothelial migration signaling pathway to induce ferroptosis in triple-negative breast cancer cells. | <h4>Purpose</h4>Triple-negative breast cancer (TNBC), characterized by the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression, remains clinically challenging due to the lack of effective targeted therapies. This investigation revealed the anti-T... |
41518473 | Transepithelial corneal cross-linking: a review. | <h4>Purpose</h4>This review aims to summarize the current understanding of transepithelial corneal cross-linking (TE-CXL) for treating keratoconus (KC). It focuses on how TE-CXL compares with the standard epithelium-off cross-linking (S-CXL) and discusses recent improvements intended to make it more effective.<h4>Metho... |
41518459 | Mevalonic acid exerts procoagulant effect by potentiating factor Xa. | Thrombosis pathogenesis is closely linked to dysregulated lipid metabolism and inflammatory processes. However, the direct regulatory role of mevalonate pathway within the coagulation cascade is still not well understood. This study aimed to elucidate the regulatory effects of mevalonic acid (MVA) on the coagulation sy... |
41518403 | Recent advances in multimodal imaging of infections: research highlights using Nuclear-Optical imaging. | Multimodal imaging using hybrid imaging agents is a promising strategy for diagnosing and evaluating pathologies after image-guided surgical interventions. Combining optical and radioactive imaging techniques provides a comprehensive approach to monitoring and diagnosing infections, which would be more effective than r... |
41518295 | Reversibly Redox-Active Iron Oxide Structures in FeNC Catalysts Identified by Microscopy and Spectroelectrochemical EPR and Mössbauer Methods. | Identifying active sites in FeNC catalysts for oxygen reduction reactions (ORR) and active site changes during preparation, storage, and electrochemical cycling are key challenges in the quest for improved catalysts. In this work, high-resolution transmission electron microscopy (TEM) is combined with <sup>57</sup>Fe M... |
41518294 | Heptazine-Assisted Multi-Resonance TADF Emitters With Fast Reverse Intersystem Crossing for Efficient Solution-Processed OLEDs. | The development of solution-processed organic light-emitting diodes (SP-OLEDs) with narrowband emission, high brightness, and minimal efficiency roll-off remains a significant challenge. Herein, we report a series of heptazine-assisted multi-resonance thermally activated delayed fluorescence (MR-TADF) emitters for high... |
41518289 | Anthracene Bisurea as a Supramolecular Chloride Receptor for Additive-Free, Broad-Scope Gold(I) Catalysis. | Gold catalysis provides access to a remarkable array of complex carbon scaffolds, but the use of silver salts to activate gold(I) chloride precatalysts can be problematic due to Ag(I) light sensitivity, hygroscopicity, redox activity, and interference with the desired catalysis. Although H-bond donors are a promising a... |
41518286 | Carbonized Polymer Dots as Versatile Nanocarrier for Bioincompatible Fluorophore Imaging. | Fluorophores with excellent emission often come at the cost of cell permeability, and this long-standing dilemma has limited their effective applications in fluorescence bioimaging to some degree. We report a paradigm-shifting discovery that carbonized polymer dots (CPDs) can function as a versatile, noncovalent transl... |
41518283 | Peptide-Induced Ferroelectricity in Charge-Transfer Supramolecular Materials. | Organic ferroelectrics are of great interest in sustainable energy conversion, information storage, flexible electronics, and potential biomedical applications as soft implants, among many other applications. Despite their broad potential, the development of organic ferroelectrics has remained limited, with only a few ... |
41518281 | Biomimetic NaK Channel Membrane Enabled by a Crown Ether-Coordinated Metal-Organic Framework. | Biological NaK channels integrate exquisite ion selectivity with dynamic gating to regulate life processes, yet achieving such multifunctionality in synthetic channels has remained a formidable challenge. Here, we present a metal-organic framework (MOF) channel membrane that combines two complementary ion-conduction mo... |
41518280 | One-Pot Transition-Metal-Free Methods for the Synthesis of All Three Bonds of the Alkyne's Triple Bond. | Alkynes are among the most useful functional groups in synthetic chemistry, as they are excellent starting materials for various reactions and serve as valuable precursors during total synthesis. Despite the high number of transformations that utilize alkynes as substrates, few methods actually exist to synthesize them... |
41518275 | Thiourea-Functionalized Ionizable Lipids Enable Systemic mRNA Delivery to Secondary Lymphoid Organs and Dual-Modal Lymphatic Metastasis Imaging. | Systemic delivery of messenger RNA (mRNA) to non-hepatocytes using lipid nanoparticles (LNPs) remains challenging. Inspired by anion coordination chemistry, here we report the rational chemical design of thiourea-functionalized ionizable lipids (TUILs) for delivering mRNA potently and specifically to the secondary lymp... |
41518270 | Synthetic Studies Towards Darobactin A. | We describe our efforts toward the total synthesis of darobactin A, an antibiotic that selectively targets Gram-negative bacteria. The first route comprised the preparation of two separate advanced fragments. The unusual ether-linked tryptophan moiety was constructed utilizing a nucleophilic aromatic substitution-Barto... |
41518257 | Dual-Induced Confined Synthesis of Metastable γ-MnO<sub>2</sub> Nanoclusters in Metal-Organic Frameworks for Highly Efficient Ozone Decomposition. | Ultrafine metal oxide nanoclusters (UMONs) exhibit remarkable catalytic potential due to their high specific surface area; however, achieving precise control over both the size and crystal phase of UMONs remains a significant challenge. Herein, we developed a dual-induced confined synthesis strategy that couples hydrop... |
41518253 | A Michaelis-Arbuzov-Type Pathway to a Protected 2'-Deoxy-2'-Selenomethyl-Adenosine-3',5'-Phosphoroselenolate Guanosine Dinucleotide for Use in Modified m7G Cap Synthesis. | In this paper, a solution-phase total synthesis is described of the 5'-O-phosphorylated 2'-deoxy-2'-selenomethyl-adenosine 3',5'-phosphoroselenolate guanosine dinucleotide (4) using a rt, 2,6-lutidine-mediated, nucleoside 3'-H-phosphonate/5'-selenocyanate Michaelis-Arbuzov ligative coupling, whose potential mechanism i... |
41518252 | Design of Adsorption‒Diffusion Dual-Driven MOF Membranes for Efficient CO<sub>2</sub> Separation. | Metal-organic frameworks (MOFs) offer exceptional tunability in pore structure and functionality, holding considerable potential for advanced gas separation membranes. However, their advancement is restricted by the permeability-selectivity trade-off and inefficient empirical screening. Herein, we propose an adsorption... |
41518247 | High-Throughput Screening of Experimental Metal-organic Frameworks for High Water Content Syngas Hydrogen Purification under Pressure Swing Adsorption Conditions. | Metal-organic frameworks (MOFs) are promising sorbents for adsorption-based hydrogen (H<sub>2</sub>) purification in blue hydrogen process, but existing large-scale computational screenings rarely examine adsorption performances of MOFs under elevated pressure, temperature and high water content, which is typical of in... |
41518245 | Programmable DNA Nanostructures for hTERT Compartmentalization and Translocation in Living Cells. | Protein translocation is essential for cellular function, and compartmentalizing proteins can regulate their activity. However, constructing artificial intracellular compartments to control this process remains a significant challenge. Herein, we report the artificial dynamic assembly of DNA condensates in the cytoplas... |
41518244 | Programmable Aptamer-Controlled Fibrinogenesis Using Dynamic DNA Networks and Synthetic Transcription Machineries. | ConspectusFibrinogenesis─the transformation of fibrinogen to fibrin─is one of the most significant physiological pathways regulating hemostasis by promoting clot formation at vascular injury sites. Thrombin is the key catalyst driving fibrinogenesis, and thus the control of its activity is of utmost medical significanc... |
41518242 | Geometry Controls Confined Water Dynamics in Lipidic Mesophases. | Water under nanoscale confinement is central to biological function, catalysis, and soft materials, yet how geometry dictates its structure and dynamics remains unresolved. Here, we establish a direct link between interfacial curvature and confined water behavior using an archaeal-inspired phytantriol-water lipidic mes... |
41518241 | Regulation of the D-Band Center Through Ligand Engineering in Silver Cluster-Based MOFs Enhances Acidic CO<sub>2</sub> Electroreduction. | Acidic electrochemical CO<sub>2</sub> reduction reaction (eCO<sub>2</sub>RR) offers a promising way for achieving high CO<sub>2</sub> utilization efficiency and circumventing carbonate deposition issues. However, it is plagued by a compromised catalytic performance due to the severe hydrogen evolution reaction (HER). H... |
41518240 | Selective Singlet Oxygen Generation over a Silver-Porphyrin Single-Atom-Site Catalyst for Ultrafast Sulfide Photooxidation. | The selective oxidation of sulfides to sulfoxides represents a fundamental transformation in synthetic and pharmaceutical chemistry, yet most catalytic systems require harsh conditions or long reaction times. Herein, we report a silver-porphyrin single-atom-site catalyst (Ag-TMPP; TMPPH<sub>2</sub> = tetrakis(4-methylp... |
41518234 | Twists and Turns of Liquid Crystals Unravelled by Small-Angle Scattering. | X-ray scattering is a highly versatile characterization method and has seen widespread use across all fields of science. Previous review articles pertaining to small- and wide-angle X-ray scattering (SWAXS) have either been highly specific or narrow in scope. Generally, other SWAXS reviews have been mainly tailored tow... |
41518082 | Nanoemulsions for Skin Delivery of Essential Oils: A Systematic Review. | Essential oils (EOs) are recognized for their multiple health benefits. However, their high volatility, low stability, and limited water solubility limit their effective application. This systematic review aims to assess the use of nanoemulsions as delivery systems for the topical administration of EOs, highlighting th... |
41514360 | Tumor-homing cerium nanozyme platform enables coordinated drug release and STING activation for bladder cancer treatment. | Non-muscle-invasive bladder cancer (NMIBC) carries 70% incidence yet remains plagued by high recurrence because single-modality chemotherapy or immunotherapy is crippled by rapid urinary clearance, poor tumor specificity, and narrow therapeutic windows. To overcome these challenges, we develop a homologous-targeted cer... |
41513886 | Artificial Intelligence Empowered New Materials: Discovery, Synthesis, Prediction to Validation. | Recent years have witnessed the significant breakthrough in the field of new materials discovery brought about by the artificial intelligence (AI). AI has successfully been applied for predicting the formability, revealing the properties, and guiding the experimental synthesis of materials. Rapid progress has been made... |
41513859 | Theoretical insights into the optoelectronic and charge-transfer characteristics of 5-(1H-1,2,4-triazol-1-yl)-2-thiophenecarboxylic acid. | This study elucidates the electronic and structural interplay of 5-(1 H-1,2,4-triazol-1-yl)-2-thiophenecarboxylic acid (TTCA) to assess its potential as a multifunctional heteroaromatic scaffold. Using DFT and TD-DFT calculations at the B3LYP/6-311 + + G(d, p) level, we demonstrate that intramolecular hydrogen bonding ... |
41513834 | Functionalized Wood: A Green Nanoengineering Platform for Sustainable Technologies. | Wood, once regarded primarily as a structural material, possesses rich physicochemical complexity that has long been underexplored. In the context of industrialization and carbon imbalance, it is now emerging as a renewable and multifunctional platform for green nanotechnologies. Recent advances in wood nanotechnology ... |
41513660 | Alleviating non-radiative losses in organic solar cells through side-chain regulation of low-bandgap non-fullerene acceptors. | Non-radiative losses present a significant hurdle limiting the performance of organic solar cells (OSCs). Selenium substitution in non-fullerene acceptors (NFAs) is an effective approach for tuning intermolecular stacking and energy levels in state-of-the-art near-infrared absorbing OSCs. However, the inter-system cros... |
41503690 | The essential role of heparan sulfate in the entry of PDCoV and other porcine coronaviruses. | Porcine enteric coronaviruses, including porcine deltacoronavirus (PDCoV), porcine epidemic diarrhea virus (PEDV), swine acute diarrhea syndrome coronavirus (SADS-CoV), and transmissible gastroenteritis coronavirus (TGEV), can cause acute diarrhea, vomiting, dehydration, and high mortality in suckling piglets. Recent s... |
41923969 | Cosmeceuticals in acne vulgaris: from mechanism of action to clinical application. | The use of cosmeceuticals in acne vulgaris is becoming increasingly prevalent with many over-the-counter formulations becoming part of patients' routine skincare. Cosmeceuticals are often used successfully as an adjunctive therapy to reduce the side effects of traditional prescriptions and improve compliance. This is a... |
41858585 | Nanomaterial-Induced Bacterial Ferroptosis-Like Death: A Novel Strategy to Counteract Antimicrobial Resistance. | The escalating crisis of antimicrobial resistance (AMR) poses a profound threat to global public health, necessitating the development of alternative antibacterial strategies. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has recently emerged as a promising strategy for comba... |
41810466 | From bench to bedside: Unveiling the background and benefits of nanovaccines tested in clinics. | Despite the growing body of literature on nanovaccines, focused analyses of platforms tested in and undergoing clinical investigation remain limited. This review addresses this gap by critically examining recent advancements and highlighting nanovaccine technologies that have undergone human clinical trials. Using an e... |
41660122 | Engineered microalgal extracellular vesicles for efficient doxorubicin delivery and improved therapeutic efficacy in breast cancer. | Extracellular vesicles (EVs) have emerged as versatile and biocompatible nanocarriers for drug delivery, offering significant advantages over synthetic nanoparticles, which often suffer from rapid clearance, immunogenicity, and limited clinical translation. In this study, we introduce nanoalgosomes, a new class of EVs ... |
41638110 | Tyrosine kinase inhibitors for wet age-related macular degeneration: The current developmental landscape. | Age-related macular degeneration (AMD) is a leading cause of permanent vision loss in older patients worldwide. The neovascular (wet) AMD is characterized by abnormal choroidal neovascularization driven by vascular endothelial growth factor (VEGF), platelet-derived growth factor, and Tie2 signaling pathways, leading to... |
41604751 | Evaluating the drug delivery potential of functionalized calix [4] arene for carboplatin-drug: A computational study analyzing static electric field and solvent effects through DFT, TD-DFT, and NLO techniques. | Targeted and precise drug delivery using nanomaterials remains a major goal in cancer therapy. In this study, the interaction of carboplatin, a key anticancer drug, with pristine and functionalized calix[4]arene (CHO, COOH, NH<sub>2</sub>, NO<sub>2</sub>) was investigated under varying solvent environments (water, etha... |
41626505 | Pilot-Scale Continuous Flow Synthesis of Capsaicinoids and Their Formulation with Cyclodextrins. | Capsaicinoids are the principal compounds responsible for the pungency of chili peppers and are widely used as food additives as well as in pharmaceutical and cosmetic formulations or potential agrochemicals. However, capsaicin and its derivatives have poor aqueous solubility, which limits their broader application. In... |
41626431 | Fenton-like Catalysts Based on Supported Cu for Dyes' and Pharmaceuticals' Removal Using Only H<sub>2</sub>O<sub>2</sub> and/or O<sub>2</sub> as Oxidants: A Review Focused on the Last 10 years. | Homogeneous Fenton and Fenton-like systems have been studied for more than 100 years. Applications in environmental remediation require the immobilization of metals with this kind of activity onto suitable supports. These metals need to be in adequate oxidation states. With the growing interest in sustainability and th... |
41614200 | Synthesis of Highly Borylated 2‑Boraindanes through Multiple Borylation of Diynes. | Boraindanes, composed of aromatic two-dimensional (2D) benzene and saturated three-dimensional (3D) boracycle moieties, are considered promising candidates for bioactive compounds/probes, agents for boron neutron capture therapy, and functional materials, as they combine the photophysical properties of the 2D aromatic ... |
41613106 | Fc-enhanced anti-CCR6 antibody elicits robust therapeutic effects across multiple autoimmune diseases. | Activation of the chemokine receptor CCR6 orchestrates the trafficking of IL-17-producing pathogenic immune cells to the sites of inflammation, thus contributing to the development of numerous inflammatory and autoimmune diseases. As such, CCR6 has emerged as a promising therapeutic target for treating Th17-mediated in... |
41602142 | Natural monosaccharide-based piezoelectric supramolecular materials for energy harvesting and information transmission. | Biomolecular assemblies with non-centrosymmetric structures exhibit a piezoelectric response that can be applied to bionanotechnology. However, the piezoelectricity of monosaccharide self-assembled materials has not been previously reported. Herein, for the first time, we systematically investigated the piezoelectric p... |
41600860 | Dynamics of Tilapia Lake Virus in Recirculating Aquaculture Systems and the Impact of Vaccination on Outbreak Control. | Tilapia lake virus (TiLV) is a highly virulent pathogen that has caused substantial mortality in tilapia farms, particularly those with open-water systems. However, TiLV can also emerge and persist in closed environments, such as recirculating aquaculture systems (RAS), where environmental accumulation and repeated exp... |
41600723 | Avian Influenza Viruses: Global Panzootic, Host Range Expansion and Emerging One-Health Threats. | The review deals with the current knowledge on the global panzootic spread of highly pathogenic avian influenza viruses (HPAIVs), with an emphasis on the H5N1 clade 2.3.4.4b virus. It describes the viral structure, replication, pathotypes and molecular determinants of host range, including sialic-acid receptor usage an... |
41600236 | Electrochemical Biosensors for Exosome Detection: Current Advances, Challenges, and Prospects for Glaucoma Diagnosis. | Glaucoma is a leading cause of irreversible blindness worldwide, with its asymptomatic progression highlighting the urgent need for early, minimally invasive biomarkers. Exosomes derived from the aqueous humor (AH) have emerged as promising candidates, as they carry proteins, nucleic acids, and lipids that reflect the ... |
41599719 | Exploring the Anti-Inflammatory Effects of <i>Aloe vera</i> Flower (AVF) and Its Active Ingredients in a Skin Inflammation Model Induced by Glyoxal-Derived Advanced Glycation End Products (GO-AGEs). | <b>Objective</b>: Advanced glycation end-products (AGEs) contribute to oxidative stress and inflammation, leading to various disorders, including skin inflammation. Here, we investigated the anti-inflammatory effects of <i>Aloe vera</i> flower (AVF) extract and its active constituents, vitexin (V) and isovitexin (IV), ... |
41599480 | Antibacterial and Hydrophobic PLA Biocomposites Enabled by Geraniol-Modified Flax Fibres. | In the medical industry, strong disinfectants are used to limit bacterial proliferation on the surface of polymer-based materials; however, they may leave hazardous residues. To prevent potential harm to human health, safer disinfection substitutes are continuously searched. This study evaluates the effect of a natural... |
41599486 | Light-Induced Structural Evolutions in Electrostatic Nanoassemblies. | Studying nanoscale self-assembly in real time using external stimuli unlocks new opportunities for dynamic and adaptive materials. While electrostatic self-assembly is well-established, real-time monitoring of its structural evolution under light irradiation remains largely unexploited. In this study, we employ light-r... |
41599276 | Advanced Technologies in Extracellular Vesicle Biosensing: Platforms, Standardization, and Clinical Translation. | Recently, extracellular vesicles (EVs) have emerged as pivotal mediators of intercellular communication that reflect physiological homeostasis and pathological alterations. By encapsulating diverse biomolecules, including proteins, nucleic acids, and lipids, EVs mirror the molecular signatures of their parent cells, th... |
41599191 | Rewriting Tumor Entry Rules: Microfluidic Polyplexes and Tumor-Penetrating Strategies-A Literature Review. | Cancer immunotherapy increasingly relies on nucleic acid-based vaccines, yet achieving efficient and safe delivery remains a critical limitation. Polyplexes-electrostatic complexes of cationic polymers and nucleic acids-have emerged as versatile carriers offering greater chemical tunability and multivalent targeting ca... |
41599056 | Mumps Virus: Replication, Immune Response, and the Changing Landscape of Vaccine Effectiveness. | Mumps virus (MuV) is a single-stranded, negative-sense RNA virus of the Family <i>Paramyxoviridae</i>. MuV is a highly contagious human pathogen that causes primarily mild symptoms, including hallmark swelling of the parotid glands. Severe cases can occur, leading to neurological complications, including deafness, meni... |
41597992 | Nanostructured Silicon Anodes for Lithium-Ion Batteries: Advances, Challenges, and Future Prospects. | Silicon is considered one of the most promising next-generation anode materials for lithium-ion batteries (LIBs) because of its very high theoretical specific capacity (≈3579 mAh·g<sup>-1</sup>). However, its practical application is limited by severe volume expansion (>300%), an unstable solid electrolyte interphase (... |
41597990 | Aggregation-Tuned Charge Transport and Threshold Voltage Modulation in Poly(3-hexylthiophene) Field-Effect Transistors. | In this report, a thickness-driven, aggregation-structure-transport optimum in sonicated poly(3-hexylthiophene) (P3HT) FETs was investigated. Mobility peaks at ~10-20 nm, coincident with a minimum in the photoluminescence (PL) vibronic ratio I0-0/I0-1 (strong <i>H</i>-aggregate interchain coupling) and X-ray diffractio... |
41596848 | Polysaccharides Extraction from <i>Opuntia milpa alta</i> and Their Protective Effect on Alcohol-Induced Neuro 2a Cell Damage via Ferroptosis. | Alcohol enters the brain through the blood-brain barrier and causes neuronal damage in various ways, additionally long-term and heavy drinking also leads to both structural and functional changes in the central nervous system. Currently, there is a lack of specific therapeutic approaches for alcohol-induced nerve injur... |
41596847 | Clean-Label Starch Modifications: Dry Heat Treatment in Combination with Ion Exchange. | Potato starch offers the unique potential of mineral enrichment through the presence of phosphorylated amylopectin chains. This property was utilised in a straightforward dual modification of native potato starch by combining mineral enrichment with dry heat treatments (DHT). DHT itself (110-130 °C, 3-6% moisture, 2 h)... |
41596845 | Encoded Microspheres in Multiplex Detection of Mycotoxins and Other Analytes. | This paper provides a systematic review of the progress in encoded microsphere suspension array technology and its application in the multiplex detection of mycotoxins. Mycotoxins are diverse and frequently coexist in food matrices, leading to synergistic toxic effects. This poses significant challenges to existing ris... |
41596355 | Modern Quantum Chemistry Methodology for Predicting <sup>31</sup>P Nuclear Magnetic Resonance Chemical Shifts. | Phosphorus-31 nuclear magnetic resonance (<sup>31</sup>P NMR) spectroscopy is a powerful analytical physical chemistry experimental technique that is widely used to study the structure and dynamics of phosphorus-containing compounds today. Accurate calculation of <sup>31</sup>P NMR chemical shifts lies in the basis of ... |
41596323 | Dissecting the Interaction Domains of SARS-CoV-2 Nucleocapsid Protein and Human RNA Helicase DDX3X and Search for Potential Inhibitors. | The SARS-CoV-2 nucleocapsid protein (Np) plays multifunctional roles in the viral life cycle. By interacting with host cellular proteins, Np regulates viral RNA transcription, replication, and immune evasion. It controls genome packaging and counteracts host RNA interference mediated antiviral responses through its RNA... |
41596344 | Exercise-Based Mechanotherapy: From Biomechanical Principles and Mechanotransduction to Precision Regenerative Rehabilitation. | Mechanical loading generated during physical activity and exercise is a fundamental determinant of musculoskeletal development, adaptation, and regeneration. Exercise-based mechanotherapy, encompassing structured movement, resistance training, stretching, and device-assisted loading, has evolved from empirical rehabili... |
41596342 | Understanding the Secular Decline in Testosterone: Mechanisms, Consequences, and Clinical Perspectives. | Testosterone is a key regulator of male and female physiology, influencing reproductive function, muscle and bone anabolism, metabolic homeostasis, and psychological well-being. Growing evidence indicates a secular, age-independent decline in testosterone levels across populations, a trend associated with reduced ferti... |
41596348 | Phosphatidylserine Externalization in Cancer: Biology, Immune Suppression, and Emerging Theragnostic Strategies. | Phosphatidylserine (PS) externalization is a conserved membrane stress signal that becomes chronically dysregulated in cancer cells and tumor-associated endothelium. In vivo, PS does not exist as a free lipid signal but is presented in specific membrane-associated forms, including apoptotic or stressed cell surfaces, P... |
41596341 | Membrane Stress and Ferroptosis: Lipid Dynamics in Cancer. | Membrane rupture, induced by lipid peroxidation, is a severe threat to osmotic balance, as membrane pores contribute to ferroptosis, an iron-dependent cell death. To alleviate osmotic stress, membrane constituents dynamically reconstruct the membrane and interact with intracellular molecules. Tumor-derived acidosis shi... |
41596336 | Peptide-Based Approaches for Pain Relief and Healing in Wounds. | A wound has been defined as a disruption of tissue integrity. Pain, bleeding, and the risk of infection are inherent features of wounds, while chronic wounds are often accompanied by serous exudate. Pain associated with chronic wounds is usually underestimated and inadequately addressed in routine clinical care, despit... |
41596328 | Anticancer Activity of Schiff Base Metal Complexes Against MCF-7 Breast Cancer Cell Line. | According to the World Health Organization, breast cancer is the cancer that affects the largest number of people each year, especially women. Millions of women are diagnosed with it each year, and hundreds of thousands die from it. Research into new types of drugs, including metal complexes, including those containing... |
41596145 | Polyphenols from Byproducts: Their Applications and Health Effects. | Plant byproducts represent a valuable and underutilized source of bioactive compounds. Among these, phenolic compounds have attracted growing interest from the agricultural, cosmetic, and food industries due to their diverse biological activities. These naturally occurring compounds are derived from various plant speci... |
41595672 | Comparison of the Clinical Course, Management and Outcomes of Acute Pancreatitis in Aged and Young Patients. | Acute pancreatitis (AP) is an inflammatory condition with varying severity, ranging from mild self-limiting episodes to life-threatening complications. The incidence, clinical presentation, and outcomes of AP differ significantly across age groups, with elderly patients demonstrating distinct challenges. Biliary pancre... |
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