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41594658 | Resveratrol for Cancer Treatment: Effects on Metabolism and Immune Cells. | Resveratrol is a natural polyphenol found in plants that has attracted significant research attention for its antitumor potential. With the continuing research on the tumor microenvironment and metabolic reprogramming, the roles of resveratrol in tumor cell metabolism and immune cell function have gained increasing att... |
41594109 | Ellagic Acid as a Promising Antifungal Agent: A Review of Mechanisms, Synergy, and Formulation Strategies. | Ellagic acid (EA), a naturally occurring phenolic compound, has garnered significant interest as a potential antifungal agent owing to increasing fungal resistance and a scarce therapeutic pipeline. This review consolidates the evidence of the broad-spectrum activity of EA against critical priority pathogens, including... |
41590087 | Preparation Strategy of Hydrogel Loaded with Natural Products and Its Research Progress in Skin Repair. | Hydrogels are three-dimensional hydrophilic network structures with one or more polymers cross-linked, with excellent biocompatibility, drug-carrying function, and biodegradability. Meanwhile, skin wound repair includes hemostasis and coagulation, an inflammation stage, a proliferation stage, and a remodeling stage. Th... |
41586305 | Advances in biosensor technologies for the detection of antimicrobial resistance in <i>Staphylococcus aureus</i>. | The rise of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) underscores the urgent need for rapid, sensitive, and portable diagnostics. In this paper, we have critically reviewed recent advances in biosensor technologies, integrating nanomaterials, aptamers, CRISPR/Cas systems, and microfluidic lab-on-a-chip ... |
41585563 | Synthesis-free and high-efficient molecular complexation based magnetic dispersive liquid-liquid microextraction for the efficient enrichment and determination of phenoxycarboxylic acid herbicide in various samples. | This study developed a molecular complexation-based dispersive liquid-liquid microextraction combined with magnetic particle-assisted extractant retrieval technology (MC-DLLME-MPAR) for the efficient detection of phenoxycarboxylic acid herbicide (PCA) residues in fruits, vegetables, and herbal plants. The proposed meth... |
41584670 | A precise berry counting method for in-cluster grapes to guide berry thinning. | In table grape production, berry thinning is a vital management practice where workers remove berries to achieve a target number per cluster. However, this process fundamentally depends on obtaining an accurate initial berry count, which currently relies on manual methods. These conventional approaches are labor-intens... |
41584669 | Agrochemical innovation for crop health: moving forward through dynamic disorder. | Global climate change has huge negative impacts on crop health. Strategies for increasing crop yield and resistance to biotic and abiotic stress factors (pathogenic microbes, insect pests, drought and heat waves, flooding etc.) are important to achieve sustainable agriculture for food security. Breeding for elite crop ... |
41584599 | Engineering the next generation of CAR T- cells: precision modifications, logic gates and universal strategies to overcome exhaustion and tumor resistance. | Chimeric antigen receptor (CAR) T-cell therapy has transformed the treatment landscape of hematologic malignancies, delivering durable remissions in diseases previously associated with poor outcomes. However, translating this success to solid tumors has proven challenging due to antigen heterogeneity, limited tumor inf... |
41584452 | Isolation, characterization, and biological evaluation of endophytic fungi from <i>Phragmites australis</i>: experimental and computational insights. | Endophytic fungi are an uncharted source of bioactive metabolites with varied therapeutic characteristics. In this research, an endophytic <i>Aspergillus</i> sp. (HAG1) was collected from <i>Phragmites australis</i> and identified using morphological and molecular methods. The large-scale fermentation, chromatographic ... |
41583450 | Prostate-specific membrane antigen targeted organic semiconducting polymer nanoparticles for enhanced photothermal therapy of prostate cancer. | Photothermal therapy (PTT) in the second near-infrared window (NIR-II, 1000-1700 nm) enables deep-tissue penetration and reduced off-target damage, offering a promising approach for localized cancer ablation. A major challenge, however, lies in achieving efficient and tumor-specific accumulation of photothermal agents.... |
41583439 | Engineering neuroimmune regulation: biomaterial and nanotechnology platforms for neuropathology diagnosis and targeted immunomodulation. | The immune system is a potent and interwoven regulator of neuropathology in the central nervous system (CNS). For example, gliomas, neurodegenerative diseases, and autoimmune neuroinflammation all have diverse etiology and pathogenesis. Yet, there are numerous similarities in immunological dysfunction between these neu... |
41582943 | Elastic, load-bearing and autoclavable protein-based graft for coronary revascularization. | Autologous grafts, such as the internal mammary artery and saphenous vein, are considered the gold standard for coronary artery bypass. However, there is a critical need for small diameter vascular grafts to meet the demands of coronary artery disease patients, as limitations become especially pronounced due to the ext... |
41584600 | Frontiers of cytokine engineering in CAR cell therapy for cancer. | Chimeric antigen receptor (CAR)-engineered T (CAR-T) cell therapy has revolutionized the treatment of hematologic malignancies, yet its efficacy in solid tumors remains limited by T cell exhaustion, restricted tumor infiltration, and an immunosuppressive tumor microenvironment (TME). Recent advances in cytokine enginee... |
41583433 | Lactylation in cancer: mechanistic insights, tumor microenvironment, and therapeutic horizons. | The discovery of lactylation, a post-translational modification derived from lactate, has fundamentally altered the perception of cancer metabolism. Once regarded as a metabolic waste product, lactate is now recognized as a central fuel source, a signaling molecule, and an epigenetic substrate capable of reprogramming ... |
41577620 | Spiral-fluorene-integrated sterically shielded multi-resonance TADF emitter: simultaneously achieving narrowband emission and restraining Dexter energy transfer. | The fundamental challenge in achieving high doping concentrations for multiple resonance emitters, while simultaneously suppressing Dexter energy transfer (DET)-induced concentration quenching, stems from their intrinsically long-lived exciton states. Moving beyond conventional steric hindrance strategies for intermole... |
41558941 | Photo-responsive polyprodrug supramolecular assemblies with self-accelerated subcellular delivery for synergistic photochemotherapy. | Targeted drug delivery with spatiotemporal control is critical for potent cancer therapy, yet inadequate subcellular delivery remains a major obstacle for DNA-targeted therapeutics due to multiple intracellular barriers. Herein, we report a photo-responsive polyprodrug supramolecular assembly to yield self-accelerated ... |
41550561 | Ultrabright and narrowband organic afterglow achieved by molecular engineering of coronene. | Achieving simultaneously ultrabright and narrowband organic afterglow emission remains a formidable challenge because enhancing one property often compromises the other. Herein, we report a low-frequency vibronic coupling strategy to design intrinsic narrowband organic afterglow materials that combine high brightness w... |
41548471 | Rapidly self-healing, highly adhesive, ionically conductive adhesives enabled by synergistic hydrogen bonding and coordination interactions. | In recent years, the demand for flexible electronics in areas such as wearable sensing and human-machine interface has surged dramatically. To enhance the stability and comfort of devices while prolonging their service life, self-adhesion and self-repair functionalities have emerged as crucial study areas in this domai... |
41547022 | Aptamer-regulated silver core-cuprous oxide shell nanozyme for surface-enhanced raman scattering and colorimetric dual-mode detection of kanamycin in food. | This work developed a dual-mode sensor based on aptamer regulation of silver core-cuprous oxide shell (Ag@Cu<sub>2</sub>O) nanozyme activity for kanamycin detection. The synthesized Ag@Cu<sub>2</sub>O nanoparticles served as both a surface-enhanced Raman scattering activity (SERS) substrate and a peroxidase-like cataly... |
41538988 | A dual-defective electrocatalyst for methanol oxidation reaction coupled seawater splitting. | Seawater electrolysis is considered a sustainable green hydrogen production route, but it is limited by high energy consumption, corrosion, and the competing chlorine evolution reaction (ClER). This study replaces oxygen evolution reaction (OER) with a low-potential methanol oxidation reaction (MOR) to reduce energy co... |
41538662 | Therapeutic massage with nanostructured lipid carrier gel containing quercetin for muscle injury treatment in rats. | Quercetin has therapeutic potential in the treatment of musculoskeletal lesions, but presents poor oral absorption because of its low water solubility and structural instability. Its penetration through the skin can be enhanced by quercetin-loaded nanostructured lipid carriers (NLC-Q), which is increased when applied w... |
41538584 | Chemical characterization of crude oil from Pennisetum glaucum (L.) R. Br. | Pearl millet oil is extracted from the grains of a cereal grown in arid and semi-arid regions, recognized for its climatic resistance and nutritional value. Pearl millet oil has a fatty acid profile similar to maize oil; however, it exhibits greater antioxidant activity and contains bioactive substances distinct from t... |
41534176 | Gold nanoparticles decorated with fluorinated poly(ethylene oxide): structural and functional insights. | Fluorinated hybrid organic-inorganic nanomaterials have attracted interest for applications ranging from biomedicine to superhydrophobic surfaces. However, few examples of fluorinated hybrid nanoparticles (F-NPs) establish a clear relationship between the structure of the fluorinated component and the properties of the... |
41529416 | Structural-coupling driven cobalt metalloporphyrin⊂MIL-101(Fe) hybrids for efficient photocatalytic CO<sub>2</sub> reduction. | Enhancing the photocatalytic CO<sub>2</sub> conversion efficiency of metal-organic frameworks (MOFs) remain a central challenge in advancing carbon capture and utilization (CCU) technologies. Herein, we report a mixed-ligand strategy to construct a hybrid MOF (denoted as CTN ⊂ NM) by incorporating a Co-metalated tetrak... |
41523283 | Biological Activities, Health Benefits and Synthesis of Equol and Its Derivatives: A Comprehensive Review. | Equol is a metabolite transformed from daidzein by intestinal microorganisms and has received extensive attention due to its various pharmacological activities and therapeutic potential. In recent years, with the in-depth study of the biological activity of equol, the development of its derivatives has gradually become... |
41522870 | Converting natural biopolymers to sustainable bioplastics <i>via</i> structure engineering. | Sustainable bioplastics have attracted considerable attention as alternatives to conventional petroleum-based plastics in response to growing concerns about resource depletion and environmental pollution. Natural biopolymers, such as starch, cellulose, and chitin/chitosan, are emerging as promising candidates for biopl... |
41522607 | Advances in Optical Biosensors for Pesticide Detection. | The growing imperative to ensure food safety, preserve ecological integrity, and mitigate public health risks associated with pesticide residues has driven a critical demand for highly sensitive optical sensors. In this regard, optical biosensors, including fluorescence (FL), colorimetry (CL), surface-enhanced Raman sc... |
41522250 | Green-engineered agricultural-based nano-adsorbent for efficient Cr(vi) removal: batch mechanisms and continuous column performance. | This study presents a green, cost-effective, and sustainable strategy for remediation of Cr(vi) from surface water. The approach employs a bio-based nano-adsorbent derived from watermelon leaves, integrated with green-synthesised TiO<sub>2</sub> nanoparticles using <i>Cajanus cajan</i> leaf extract. The acid-modified n... |
41520974 | In silico prediction of faba bean necrotic yellows virus proteins and their interactions with host protein SnRK1 through expression analysis. | Faba bean necrotic yellows virus (FBNYV) is a multipartite nanovirus (family Nanoviridae) that poses a significant threat to legume crops worldwide. Its genome encodes various viral proteins that promote infection, systemic spread, and vector transmission. This study evaluated the interaction dynamics between the sucro... |
41520954 | Dendrimer-based therapeutics in neurological disorders: Innovations and clinical prospects. | The incidence of brain tumors and other neurodegenerative diseases has been increasing, whereas the treatment opportunities are limited. Brain delivery of the therapeutics has been restricted because of the presence of blood-brain barrier (BBB). Only molecules of molecular weight <400 Da and lipid-soluble are able to c... |
41520756 | Bimetallic atom incorporation in MOFs: Real-time patch to existing synthesis/characterization insights and initial observations on their applications in water purification. | Recently, Metal-organic framework (MOF)-derived diatomic catalysts (DACs) have emerged as novel optimal candidates for advanced oxidation processes (AOPs). Currently, several reviews have summarized MOF-derived DACs and their applications in AOPs. However, novel perspectives yet to be reported and in-depth discussions ... |
41519090 | FeCu bimetallic active sites construction via hexagonal boron nitride electron regulation for high-performance electro-Fenton degradation of Rhodamine B. | The development of efficient, stable, and easily recyclable cathodes is crucial for advancing the wide application of Electro-Fenton (EF) technology. This study introduces a novel design strategy by integrating hexagonal boron nitride (h-BN) into MIL-101(FeCu) via electrospinning-carbonization techniques, yielding a se... |
41518795 | Unveiling potential Helicobacter pylori vaccine candidates: A comprehensive multi-epitope approach. | Helicobacter pylori is a pathogen known to cause persistent inflammation, leading to a wide spectrum of gastrointestinal diseases and gastric lesions. The chronic nature of this infection critically depends on host immune recognition and antigen presentation mechanisms, particularly those mediated by the major histocom... |
41517865 | Reconfigurable Acoustofluidic Microvortices for Selective Microcargo Delivery. | Microscale cargo delivery systems improve precise therapies by enabling delivery of microscale payloads deep into anatomical cavities through complex microvascular networks. Traditional methods face challenges, such as slow infusion, low payload throughput, and poor selectivity at microchannel bifurcations. Inspired by... |
41517858 | Dipiperazine-Phenyl Derivatives Based on Convergent Molecular Platforms Can Reverse Multidrug Resistance in Gram-Negative Bacteria by Inhibiting Efflux and Permeabilizing Cell Membranes. | With the global surge of infections caused by multidrug-resistant (MDR) Gram-negative bacteria, there is an urgent need for breakthrough therapeutic approaches. To overcome the intrinsic resistance mechanisms of bacteria, End-alkyl-modified dipiperazine-phenyl derivatives are designed via convergent molecular platforms... |
41514506 | Ionic Highways under Multivariate-Coupled Strategies: Ultrahigh Power Generation from Industrial Waste Liquors Using Robust COF Membranes. | Efficiently harvesting the intrinsic energy from low-grade heat, acidity, and high salinity of desulfurization waste liquors is crucial for sustainable management, yet remains challenging due to the instability of conventional membranes under such extreme multi-physics conditions. Herein, we report a high-performance o... |
41514330 | The c-di-AMP binding protein NadD from Mesomycoplasma ovipneumoniae functions as a phosphodiesterase that inhibits host inflammatory responses. | Cyclic dimeric adenosine monophosphate (c-di-AMP) is a second messenger commonly found in bacteria, particularly within the Firmicutes and Actinobacteria phyla, as well as in Archaea. Phosphodiesterase (PDE) is an enzyme that plays a crucial role in regulating the homeostasis of bacterial c-di-AMP and is capable of hyd... |
41514309 | Early antioxidant capacity, intestinal barrier integrity and gut microbiota drive DHAV-3 resistance in ducks. | <h4>Background</h4>Selective breeding for disease resistance is an effective strategy to control duck hepatitis A virus type 3 (DHAV-3) in waterfowl. However, the mechanism underlying resistance remains poorly understood, particularly those associated with antioxidant defense, intestinal development and host-microbiota... |
41514155 | Autophagy in Rheumatoid Arthritis: Molecular Mechanisms, Diagnostic Biomarkers, and Emerging Therapeutic Strategies. | Rheumatoid arthritis (RA) is a chronic autoimmune disorder marked by persistent synovial inflammation, joint destruction, and systemic complications. Recent research has revealed the complex involvement of autophagy, a cellular degradation and recycling process, in the pathogenesis and progression of RA. This review pr... |
41514103 | A self-calibrated electrochemical aptasensor based on DNA-mediated Au/PB NFs and Pt/ZnCo MOF for the detection of OTA. | A self-calibrated ratiometric electrochemical aptasensor was developed for the detection of ochratoxin A. This sensor is based on DNA-mediated gold/prussian blue nanoflowers (Au/PB NFs), methylene blue/platinum/zinc-cobalt metal-organic framework (MB/Pt/ZnCo MOF), and an exonuclease III (Exo III)-driven bipedal DNA wal... |
41513808 | K5 polysaccharides inhibit SARS-CoV-2 infection by preventing spike-proteolytic priming. | SARS-CoV-2 spike glycoprotein is a promising drug target due to its crucial role in viral infection. Heparin, a long linear polysaccharide that inhibits SARS-CoV-2 infection by acting on spike, has limited antiviral applications due to its anticoagulant effect. E. coli K5 polysaccharides share the same structure as the... |
41513725 | pH-triggered clustering regulates β-sheet activation in silk assembly. | Silk fibres derive their exceptional properties from hierarchical protein organisation, yet the molecular pathways that guide this structural transformation remain poorly resolved. During regenerated silk fibroin gelation under biomimetic gradual acidification, we identify a stepwise assembly pathway comprising nanosca... |
41513699 | The testobolome in microbial testosterone metabolism and human health. | We propose the term testobolome, analogous to the estrobolome, to describe gut bacteria that metabolize testosterone. Testosterone undergoes microbial transformations similar to estrogens, potentially influencing host hormone homeostasis and health. This review defines the testobolome, identifies its known members, and... |
41513695 | Emerging non-antibiotic strategies for implant-associated biofilm infections by reprogramming the dysregulated immune microenvironment. | Implant-associated infections (IAIs) arise from immune dysregulation and the resilience of bacterial biofilms, which create a permissive niche for persistent infection. Biofilms further suppress host immunity and impair repair. Advances in nanoengineered surfaces and multifunctional antimicrobial coatings, together wit... |
41513681 | Nozzle-less electrospun eugenol-loaded gelatin nanofibers: effect on fish preservation and quality enhancement. | This study evaluates the feasibility of producing nozzle-less eugenol-infused gelatin nanofibers as active coatings to improve fish quality and shelf life during cold storage. Nanofibers were fabricated using nozzle-less electrospinning with gelatin concentrations of 10-20% and gelatin:eugenol ratios of 100:0 to 50:50.... |
41513651 | Unlocking limited electric double-layer capacity via electrochemically-driven continuous partial desolvations in carbon nanopores. | Electrochemical capacitors are primarily limited by the low electric double-layer storage capacity and narrow operating window that avoids the formation of solid electrolyte interface layers. Herein, we demonstrate that electric double-layer adsorption of solvated Na<sup>+</sup> in carbon nanopores is achievable under ... |
41513645 | Controlled magnetic bistability of a helical non-Kekulé hydrocarbon on a Au(111) surface. | Recent advances in the synthesis of graphene fragments that possess unpaired π-electrons and display high-spin ground states have unlocked possibilities to explore exotic physical phenomena related to magnetism. The high degree of spin-delocalisation makes these non-metal-based systems ideal building blocks for the con... |
41513612 | Regulation of apoptosis, ferroptosis, and pyroptosis mediated by acetylation. | Acetylation is an important post-translational modification (PTM) of proteins and plays critical roles in multiple biological processes. The modes of cell death represent different pathways leading to the final outcome of "death" for the cell, with apoptosis, ferroptosis, and pyroptosis being the most common forms of c... |
41513604 | ALDH3A1-dependent Nrf2/HO-1/GPX4 pathway supports AHR as a promising therapeutic target for ferroptosis and promotes imperatorin-mediated lung protection. | The aryl hydrocarbon receptor (AHR) is a transcription factor prominently expressed at barrier sites, while aldehyde dehydrogenase 3 family member A1 (ALDH3A1) is a metabolic enzyme implicated in oxidative stress. However, their roles in ferroptosis remain poorly understood. Imperatorin (IMP) is a bioactive compound de... |
41512333 | Customizable NAND Logic-Gate Biosensing System Enabled by an Engineered Methylation-CRISPR/Cas12a Consensus Sequence for Ultrasensitive DNA Methyltransferase Detection. | DNA methyltransferases (MTases) play crucial roles in epigenetic regulation, and their abnormal activity is closely associated with various human diseases. Here, we report a customizable NAND logic-gate biosensing platform for highly sensitive and intelligent detection of DNA adenine methyltransferase (Dam MTase). An e... |
41512157 | Axially Linked Triphyrin(2.1.1)-Metalloporphyrin Dyads: Interplay between Aromatic-Aromatic and Antiaromatic-Aromatic Systems. | Two aromatic-aromatic axially bonded dyads and two rare antiaromatic-aromatic axially bonded dyads containing the triphyrin(2.1.1)/P(O) complex of triphyrin(2.1.1) and metalloporphyrin (ZnP/Ru(CO)P) were synthesized via M<sup>II</sup>-pyridyl "N" interaction. The dyads are stable and thoroughly characterized by NMR spe... |
41512072 | Efficient lead-free antimony halide light-emitting diodes with 22% external quantum efficiency via a binary host-guest architecture. | Lead halide emitters hold great promise for next-generation light-emitting diodes (LEDs), but their heavy metal toxicity poses major barriers to commercialization. Therefore, developing efficient lead-free metal halide LEDs is highly desirable but remains a big challenge. Here, we report solution-processed lead-free an... |
41512059 | Three-component synthesis of β-thio tertiary alkylamines from simple alkenes via S<sub>H</sub>2 homolytic substitution. | Alkene difunctionalization via electrophilic aminyl radical cations offers a straightforward route to complex tertiary alkylamines widely occurring in biologically active molecules. However, only a limited variety of third reaction components have been hitherto introduced because of the challenges in capturing transien... |
41512058 | Molecular computation at equilibrium via programmable entropy. | Synthetic molecular information processing is typically designed through programming kinetic pathways, so that molecules bind, unbind, or incur conformational changes in some desired order. We demonstrate an alternative paradigm in dynamic DNA nanotechnology that programs the thermodynamic equilibrium state directly, w... |
41512036 | Highly sensitive chemiluminescence imaging of misfolded proteins in neurodegenerative models. | Protein misfolding in the brain is a key pathological hallmark of neurodegenerative diseases. Optical imaging of misfolded proteins in disease models is essential for elucidating etiology and early diagnosis. However, developing specific optical imaging probes for each misfolded protein is time-consuming and challengin... |
41512027 | Distinct PlzC mechanisms integrate chemotaxis and c-di-GMP signaling to regulate <i>Vibrio cholerae</i> motility and biofilm formation. | Bacterial motility and biofilm formation are essential for the adaptation and survival of <i>Vibrio cholerae</i>, the causative agent of cholera. In many bacterial species, the second messenger c-di-GMP regulates these processes through PilZ domain proteins, however the downstream mechanisms have remained poorly define... |
41511998 | Covalency of the Strong Br···N Halogen Bonds in Neutral and Ionic Complexes. | Halogen bonding (HaB) between bromine and nitrogen was investigated in a series of quinuclidine (QN) complexes with various bromo-substituted electrophiles and in bromine(I) species QN-Br-QN<sup>+</sup> and Sac-Br-Sac<sup>-</sup> (Sac = saccharin residue). X-ray crystallography and density functional theory (M0-2X/def2... |
41511973 | Zebrafish genetic model of neuromuscular degeneration associated with Atrogin-1 expression. | The degenerative loss of muscle associated with aging leading to muscular atrophy is called sarcopenia. Currently, practicing regular physical exercise is the only efficient way to delay sarcopenia onset. Identification of therapeutic targets to alleviate the symptoms of aging requires in vivo model organisms of accele... |
41511826 | Biomimetic Metal-Organic Framework Decorated by Artificial Bacterium-Binding Protein and Apamin for Treatment of Acute Enteritis. | Acute enteritis, commonly categorized into infectious and noninfectious types, shares similar pathological and clinical manifestations through activation of intestinal immune responses and disruption of mucosal functions. In this study, we constructed the virus assembly mimicking zeolitic imidazolate framework-8 (ZIF-8... |
41511508 | β-Cyclodextrin-Coated Paclitaxel-Loaded Mesoporous Silica Nanocarriers: Mechanistic Insights Into Sustained Release, Enhanced Cellular Uptake, and Apoptosis in MCF-7 Breast Cancer Cells. | The present study aimed to develop and evaluate β-cyclodextrin (β-CD)-coated mesoporous silica nanoparticles (MSNs) for the controlled delivery of paclitaxel (PTX) to improve its aqueous solubility, stability, and anticancer efficacy. MSNs were synthesized by a sol-gel method using cetyltrimethylammonium bromide as a s... |
41511470 | The interplay between biomolecular assembly and phase separation. | Many biological functions and dysfunctions rely on two fundamental processes, molecular assembly and the formation of condensed phases such as biomolecular condensates. Condensed phases generally form via phase separation, while molecular assemblies are clusters of molecules of various sizes, shapes, and functionality.... |
41511387 | Affinity-guided labeling reveals P2X7 nanoscale membrane redistribution during BV2 microglial activation. | ATP-gated purinergic P2X7 receptors are crucial ion channels involved in inflammation. They sense abnormal ATP release during stress or injury and are considered promising clinical targets for therapeutic intervention. However, despite their predominant expression in immune cells such as microglia, there is limited inf... |
41511108 | Structural and functional insights into the interaction between a PP01 phage gp38 tail fiber tip and an <i>Escherichia coli</i> OmpC receptor. | Bacteriophages exhibit strict host specificity, primarily determined by adsorption to bacterial surface receptors. However, the molecular basis underlying this specificity remains incompletely understood. Here, we investigate the interaction between outer membrane protein C (OmpC) of <i>Escherichia coli</i> O157 and gp... |
41511082 | N-terminal acetylation controls multiple functional aspects of the influenza A virus ribonuclease PA-X. | To counteract host antiviral responses, influenza A virus triggers a global reduction of cellular gene expression, a process termed "host shutoff." A key effector of influenza A virus host shutoff is the viral endoribonuclease PA-X, which degrades host mRNAs. While many of the molecular determinants of PA-X activity re... |
41511055 | Chemical Strategies for Controlling Sulfation in Biomacromolecules. | Sulfation is a fundamental post-translational modification that imparts negative charge and structural complexity to biomolecules, thereby regulating molecular recognition, signaling, and homeostasis across all domains of life. Yet, the ability to interrogate the biological functions of sulfation has long been hindered... |
41511051 | Conformation-Locked Near-Infrared Probes for Real-Time Visualization of G Protein-Coupled Receptor Dimers in Living Systems. | Visualizing G protein-coupled receptor dimerization in living systems remains a significant challenge due to the lack of activatable and biocompatible imaging tools. Here, we report a supramolecular near-infrared fluorophore based on a twisted intramolecular charge transfer (TICT) design whose emission is selectively a... |
41511053 | Harnessing fluorescent probes for molecular diagnosis and theranostics of atherosclerosis. | Cardiovascular disease remains a leading cause of morbidity and mortality worldwide, posing a serious threat to human health. Atherosclerosis (AS), the pathological basis of most cardiovascular diseases, is characterized by arterial wall thickening caused by chronic inflammation. In recent years, molecular probes have ... |
41510883 | Identification and Characterization of an In Silico Designed Membrane-Active Peptide with Antiviral Properties. | Broad-spectrum antivirals are urgently needed to counter emerging viral threats. Targeting the viral envelope, an essential, conserved, and host-derived structure, offers a promising strategy with a low risk of resistance. Here, we report the in silico design and experimental characterization of P1.6, a 24-mer peptide ... |
41510885 | Rupestonic Acid of Artemisia Rupestris L. Extract Treats Pulmonary Fibrosis in COPD by Targeting TGF-β1. | Pulmonary fibrosis (PF) is the final stage of lung damage, such as chronic obstructive pulmonary disease (COPD), with no effective treatment. Transforming growth factor beta 1 (TGF-β1) is a key protein involved in fibrosis and regulating inflammation. Therefore, targeting components of TGF-β1 is an effective strategy f... |
41510776 | Tailoring Lithium-Ion Coordination in Metal-Organic Frameworks via d-Orbital Control for Fast Ion Conduction. | The development of solid-state electrolytes (SSEs) is fundamentally constrained by the intrinsic trade-off between ionic transport efficiency and interfacial stability. While previous design strategies have enhanced lithium-ion conduction kinetics, the rational engineering of high-performance SSEs remains challenged by... |
41510671 | Targeting CXCL8 in post-traumatic stress disorder and Alzheimer's disease: insights from cross-disorder molecular analysis. | <h4>Background</h4>Emerging clinical evidence indicates that post-traumatic stress disorder (PTSD) may accelerate Alzheimer's disease progression, yet the molecular mechanisms linking these disorders remain poorly understood.<h4>Methods</h4>We conducted an integrative bioinformatics analysis combining blood cell profil... |
41510655 | A Flexidentate Bipyridine-Aza-Crown Ether Ligand Enables Cation-Tunable Nickel Redox Properties. | A strategy for modulating the coordination mode and redox properties of nickel complexes is introduced, using a 2,2'-bipyridine derivative featuring a flexidentate and cation-responsive aza-crown ether. The bipyridine-aza-crown ether ligand can reversibly change denticity from κ<sup>4</sup> to κ<sup>6</sup> by the addi... |
41510586 | Start, Stop, Rewind, Repeat-Cyclic Exposure of Adipose Stromal Cells-derived Cartilage Organoids to Chondrogenic and Proliferative Cues to Achieve Scaled-up and Customizable Bone Formation by Endochondral Ossification. | Developmental tissue engineering (TE) strategies recapitulating endochondral ossification (ECO)-the major ossification pathway in bone development and repair- are a promising avenue for the treatment of critical size and congenital bone defects. In this work, we develop a customizable approach using adipose stromal cel... |
41510582 | Multi-Stimulus Triggered Programmable Transformation of Molecular Motor Based Chiral Supramolecular Polymers in Water. | A notable characteristic of living organisms is their capacity to adapt to environmental changes and transform external signals into distinct responsiveness, facilitating the execution of diverse functions with motility as a key parameter. To better mimic such lifelike behavior, researchers have developed various supra... |
41508999 | Benzoyl-Xanthenoxanthenes: Versatile Chromophores for Light-Engaging Applications. | In this work, we present a modular donor-acceptor strategy that produces oxidatively stable, benzoyl-fused peri-xanthenoxanthene (PXX) ribbons with near-infrared (NIR) emission and light-harvesting properties. Benzoyl fusion at the pseudo-peri positions, achieved through intramolecular Friedel-Crafts planarization, cre... |
41508992 | Non-Statistical Assembly of Donor-Acceptor Cages for Light-Induced Charge Separation. | We report light-triggered charge separation in two discrete supramolecular architectures that self-assemble in a single step from donor (D) and acceptor (A) functionalized bridging ligands and Pd(II) cations. The "shape complementary assembly" (SCA) strategy allows for exclusive formation of the cis-[Pd<sub>2</sub>D<su... |
41508984 | Polymer Crystallization Controls Cyano-OPV Assembly for High-Performance Solid-State Fluorescence. | Cyano-substituted oligo(<i>p</i>-phenylenevinylene) derivatives (cyano-OPVs) demonstrate superior photophysical properties in solution with photoluminescence quantum yield (PLQY) of up to 87% yet experience severe aggregation-caused quenching in the solid state (PLQY typically 20%-40%), fundamentally limiting their pra... |
41508976 | Direct Hydrogen Energy Conversion on Industrial-Current-Density. | Realizing efficient hydrogen evolution reaction at an industrial scale and achieving high current density is of great significance for building a sustainable hydrogen energy system and is highly anticipated by both the scientific and industrial communities. The key to achieving this goal lies in developing a transforma... |
41508366 | Dual-function natural biopolymers for aflatoxin M<sub>1</sub>: adsorption and diagnostic applications in milk. | This study investigated the hypothesis that a natural biopolymer system could simultaneously mitigate and detect aflatoxin M<sub>1</sub> (AFM<sub>1</sub>) contamination in milk. AFM₁, the hydroxylated metabolite of aflatoxin B₁, is a potent carcinogen that remains stable during milk processing and continues to pose sig... |
41507667 | A Comprehensive Review of the Functionalized Integrated Application of Gel Polymer Electrolytes in Electrochromic Devices. | With the global push for energy conservation and the rapid development of low-power, flexible and wearable optical displays, the demand for electrochromic technology has surged. Gel polymer electrolytes (GPEs), a crucial component of electrochromic devices (ECDs), show great promise in applications. This is attributed ... |
41480745 | SRSF3-TRIM28-MDC1 prevents DNA damage caused by R-loops in fatty liver disease in mice. | Serine-rich splicing factor 3 (SRSF3) is crucial for the metabolic functions of the liver. The genetic deletion of SRSF3 in mouse hepatocytes impairs hepatic lipid and glucose metabolism and leads to fibrosis and formation of hepatocellular adenoma that progresses to hepatocellular carcinoma. SRSF3 protein is proteosom... |
41909756 | AI-integrated microfluidics for drug screening: From single cell to organ-on-a-chip. | Drug discovery remains a protracted and capital-intensive process, primarily hindered by inefficiencies in drug screening. Microfluidic technology provides a promising approach for <i>in vitro</i> drug screening, enabling physiologically relevant, high-throughput, and cost-effective analysis by mimicking key aspects of... |
41909139 | Challenges and Best Practices in Modeling Anisotropic Stresses in Soft Polymorphic Materials. | Soft polymorphic materials, such as metal-organic frameworks (MOFs) and covalent organic frameworks (COFs), often display distinct anisotropy. Yet, their phase transition behavior has been predominantly characterized under isotropic stimuli, such as temperature or pressure variations, up to now. In this work, we employ... |
41859302 | Research Progress on the Pyroptosis Mechanism and Related Active Ingredients of Natural Drugs in Spinal Cord Injury. | Spinal cord injury (SCI) is a severe neurotraumatic condition for which effective therapeutic options remain limited, and advances in clinical pharmacological research have been slow. The diverse pathophysiological alterations that occur after SCI initiate cellular pyroptosis, which in turn exacerbates tissue damage, i... |
41859060 | Unraveling the Biology of Interferon-Stimulated Genes: Mechanisms, Functions, and Clinical Implications. | Interferon-stimulated genes (ISGs) constitute a central component of host defense, orchestrating antiviral, antibacterial, immunoregulatory, and cell fate-modulating responses. Traditionally recognized for their roles in restricting viral replication through well-characterized effectors such as Mx proteins, OAS, PKR, a... |
41858581 | Mechanism-Inspired Biomaterials and Regenerative Therapies for Radiation-Induced Skin Injury. | Radiation-induced skin injury (RISI) represents the most common complication of cancer radiotherapy, severely impairing patient health and treatment adherence. Conventional therapies show limited benefits due to the complex pathological mechanisms of RISI, creating an urgent demand for more effective approaches. Emergi... |
41836720 | Cu-Cy Nps@ZIF-8@HA-Mediated Photodynamic Therapy for Cutaneous Squamous Cell Carcinoma. | <h4>Purpose</h4>The complex tumor microenvironment poses an important challenge for the effective treatment of tumors, so it is important to develop efficient multimodal nanomaterials for tumor therapy. This study introduces a novel nanomaterial, Cu-Cy Nps@ZIF-8@HA (CNZH), based on zeolitic imidazolate framework-8 (ZIF... |
41704784 | Recent advances in joule heating ultrafast technology for electrocatalysis. | Joule heating technology, as an ultrafast, efficient, and scalable synthesis strategy, provides a novel approach for the preparation of high-performance electrocatalysts toward various energy conversion systems, such as hydrogen production, metal-air battery, fuel cell, and so on. This review summarizes recent progress... |
41653498 | Oligomerization of transmembrane adenylyl cyclase isoforms. | Membrane-bound adenylyl cyclases (ACs) function as vital enzymes that convert external signals into intracellular responses through the second messenger cAMP. Traditionally viewed as monomers, ACs are now recognized to form oligomers, introducing new regulatory mechanisms. This minireview synthesizes emerging structura... |
41626495 | Synthesis and Characterization of Rubisco-Magnesium Complexes for Potential Gas Adsorption Applications. | Enzyme-based complexes represent an emerging class of functional adsorbents combining specificity and environmentally friendly potential. We proposed the development of metal-enzyme-based complexes that leverage the unique properties of magnesium metal to increase enzyme-structure integration for the formation of hybri... |
41626464 | Thermoresponsive Graft Copolymers of <i>N</i>‑Isopropylacrylamide and Hyperbranched Polyglycerol as Thermally Induced Drug Delivery and Release Nanoformulation Systems for Curcumin with High Colloidal Stability and Enhanced Anticancer Effect. | The poor solubility, stability issues, and restricted bioavailability of numerous drugs and potential pharmaceutical compounds highlight the critical need for the development of polymeric nanoparticles as effective drug delivery systems. Ideal polymers for such applications must be biocompatible, provide controlled dru... |
41626460 | Synthesis, Characterization, and Structural Aspects of a Novel Benzo[<i>b</i>]fluoranthene Hapten for PAHs. | Polycyclic aromatic hydrocarbons (PAHs) are of significant concern due to their carcinogenicity, teratogenicity, and mutagenicity. Currently, immunoassay techniques are an efficient tool for the detection of PAHs. Immunoassays are based on a specific reaction between antigen and antibody and rely heavily on antibody pe... |
41626475 | TropMol-Caipora: A Cloud-Based Web Tool to Predict Cruzain Inhibitors by Machine Learning. | Chagas disease (CD) affects approximately 8 million people and is classified as a high-priority neglected tropical disease by the WHO research and development actions. One promising avenue for drug development for CD is the inhibition of cruzain, a crucial cysteine protease of <i>T. cruzi</i> and one of the most extens... |
41626434 | Consequences of mRNA Secondary Structure on Stability against both Hydrolysis and Aggregation: The Role of Electrostatic, π-π Stacking, and Thermal Effects. | The seemingly unrelated massive aggregation of free mRNA under certain solution conditions and the well-known autohydrolysis of mRNA are actually both closely linked through its secondary and possibly tertiary structure (s/t). This hypothesis posits that s/t partially stabilizes mRNA against both autohydrolysis and mas... |
41626432 | Antimalarial Potential of Heme-Targeting Dimeric Compounds: Binding Efficacy vs. Membrane Retention Effects. | Malaria, caused by Plasmodium parasites, remains a major global health burden with high morbidity and mortality rates. Despite the availability of treatments, the therapeutic arsenal is limited, and drug resistance poses a significant challenge. Thus, discovering new antimalarial compounds is critical, and understandin... |
41623523 | Protein structural dynamics in covalent drug design: insights from irreversible and reversible covalent inhibitors. | Proteins form complex networks critical to various biological processes; many become involved in disease-related pathologies - only a subset of these proteins are considered to be druggable by conventional, non-covalent small-molecule therapeutics. Covalent drugs, which encompass irreversible inhibitors and reversible ... |
41608581 | Targeting efferocytosis for tissue regeneration: From microenvironment reprogramming to clinical translation. | Efferocytosis, phagocytic clearance of apoptotic cells (ACs), is an essential biological process that resolves inflammation and regulates tissue regeneration in various organ systems. Through removal of apoptotic cell debris, efferocytosis attenuates secondary necrosis and dampens the release of damage-associated molec... |
41602143 | Self-releasing reactive oxygen species based on the metal-to-MOF charge transfer effect boost electrochemiluminescence. | Traditional luminol-based electrochemiluminescence (ECL) systems rely on hydrogen peroxide as a co-reactant, but its limited solubility restricts luminescence efficiency and detection accuracy. Herein, a core-shell spherical zinc-based metal-organic framework (Zn-MOF) leverages its metal-to-MOF charge transfer (MMCT) p... |
41600987 | Extended Heterosubtypic Neutralization and Preclinical Model In Vivo Protection from Clade 2.3.4.4b H5 Influenza Virus Infection by Broadly Neutralizing Antibodies. | <b>Background/Objective</b>: The influenza virus remains one of the most prevalent respiratory pathogens, posing significant global health and economic challenges. According to the World Health Organization, the seasonal influenza virus infects up to 1 billion people and causes up to 650,000 deaths, annually. Despite i... |
41600209 | PLA/MWNTs Conductive Polymer Composites as Stress Sensors-The Role of Supramolecular Ordering. | The incorporation of carbon nanostructures into polymer composites is of significant importance for the development of novel sensor materials, due to the excellent mechanical strength and variable electrical conductivity that these structures provide. It is evident that the significance of polylactide (PLA) and carbon ... |
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