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41501914 | The scientific basis of synergy in traditional Chinese medicine: physicochemical, pharmacokinetic, and pharmacodynamic perspectives. | Traditional Chinese medicine, with millennia of history, demonstrates significant therapeutic efficacy against diverse diseases. A key characteristic of traditional Chinese medicine lies in the use of compound formulas-multi-herb concoctions that enhance efficacy and mitigate toxicity. The synergy within these formulas... |
41501624 | Retroelement expansions underlie genome evolution in stingless bees. | Stingless bees serve as crucial pollinators and are increasingly recognized as models for investigating behavioral and genomic evolution in insects. In the genus Melipona, a major difference in heterochromatin organization defines two groups: Group I species (e.g., M. quadrifasciata) with < 50% of pericentromeric heter... |
41501552 | Pathology and viral evolutionary dynamics in a hamster model of persistent SARS-CoV-2 infection. | SARS-CoV-2 infection typically resolves within weeks, but rare cases of prolonged replication-sometimes exceeding a year-have been documented, particularly in immunocompromised individuals. These persistent infections pose health risks and may give rise to highly divergent variants, yet the underlying biology remains p... |
41501073 | Pulsed evolution shaped extant angiosperm pollen disparity. | Pollen grains, the male gametophyte of seed plants, are enclosed within sporopollenin walls that yield remarkable structural diversity and exceptional preservation, making them invaluable proxies for past plant diversity. Despite their importance, the diversification patterns of angiosperm pollen are not well quantifie... |
41501010 | ZIF-8/SnO<sub>2</sub> based high sensitivity ethylene gas sensor with Au-GO doped. | Metal oxide semiconductor gas sensors exhibit significant advantages in gas detection due to their high sensitivity and low cost. However, challenges such as poor selectivity and insufficient stability remain critical scientific issues. In this study, tin dioxide nanomaterials with a unique structure were successfully ... |
41347490 | On the role of cation-DNA interactions in surface-assisted DNA lattice assembly. | Surface-assisted DNA lattice assembly is used in the synthesis of functional surfaces and as a model of supramolecular network formation. Here, competitive DNA binding of different cation species is investigated by molecular dynamics simulations and correlated with experiments of surface-assisted DNA origami lattice as... |
41347356 | Structural isomerism in Ce-MOFs directs Ni/CeO<sub>2</sub> catalyst design for selective fatty acid deoxygenation to linear α-olefins. | We report a structural isomerism engineering of Ce-MOF precursors to design Ni/CeO<sub>2</sub> catalysts featuring abundant oxygen vacancies and highly dispersed Ni<sup>0</sup> sites, enabling complete conversion of stearic acid with 82.4% selectivity toward linear α-olefins. Mechanistic studies reveal a synergistic in... |
41114704 | Chirality driven self-sorting in supramolecular assemblies of π-conjugated systems. | Self-sorting, the process by which molecules selectively recognize and assemble with identical or complementary partners, forms the basis of the formation of complex, functional supramolecular architectures in natural systems. Inspired by nature's precision, π-conjugated systems have been engineered to self-assemble in... |
40744724 | Targeting Aurora kinase B regulates cholesterol metabolism and enhances chemoimmunotherapy in cholangiocarcinoma. | <h4>Background</h4>Cholangiocarcinoma (CCA) is a highly lethal malignant tumour with increasing incidence. Current therapies exhibit limited benefits, which urgently demand the identification of novel therapeutic targets.<h4>Objective</h4>We aimed to identify potential therapeutic targets for CCA and broaden current th... |
41858526 | Emerging Targeted and Multimodal Therapeutic Strategies in Breast Cancer: A Comprehensive Review. | Breast cancer treatment has advanced substantially with the development of targeted and multimodal strategies, yet tumor heterogeneity and therapeutic resistance continue to limit long-term outcomes. This review provides a concise and critical overview of established and emerging targeted therapies, with emphasis on re... |
41835118 | Identification of PANoptosis-Related Biomarkers in Hypertrophic Cardiomyopathy: Insights from Multi-Omics Analysis. | <h4>Background</h4>Hypertrophic cardiomyopathy (HCM) is a common inherited cardiomyopathy characterized by ventricular hypertrophy, fibrosis, and increased risk of sudden cardiac death. However, the underlying molecular pathways contributing to its progression remain incompletely defined. PANoptosis, a newly defined in... |
41767484 | Effect of Monomer Polarity on Polymer Dynamics, Glass Transition, and Ionic Conductivity of Polyether Electrolytes. | Combining X-ray scattering, Fourier transform infrared spectroscopy (FT-IR), broadband dielectric spectroscopy (BDS), rheology, and differential scanning calorimetry (DSC), we investigate the ion solvation structures, the polymer dynamics, glass transition, and ionic conductivity of poly-(butylene oxide) (PBO, static d... |
41696434 | Development of nanoparticle-based Toll-like receptor agonists for respiratory immunotherapy. | Respiratory diseases are global health challenges demanding innovative immunotherapy solutions. Toll-like receptors (TLRs) play a crucial role in immune responses, making them attractive therapeutic targets. This review examines nanoparticle-based Toll-like receptor agonists as a promising approach for respiratory immu... |
41693895 | Speckle tweezers near water-oil and water-air interfaces. | Contemporary approaches for multiple optical micro-manipulation typically involve careful pre-engineering of the laser beam shape. In various biomedical and microfluidic scenarios, especially those necessitating unconventional specimen chambers, there is a demand for controlling the collection of micro-objects near flu... |
41685175 | Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral-Like Immunomodulatory Responses and Potent Adjuvant Activity. | The rise of personalized medicine demands affordable biomaterials with tunable physicochemical properties, biological activities, and immune responses. We introduce a nucleic acid nanoparticle (NANP)-based platform designed to engage with the human immune system in a controllable manner. By varying the chemical composi... |
41660249 | Research progress in triboelectric nanogenerators based on new inorganic materials. | Based on contact electrification and electrostatic induction, triboelectric nanogenerators (TENGs) have emerged as a prominent technology for mechanical energy harvesting and conversion. Recent advances have been driven by new inorganic materials, including perovskites, graphene and its derivatives, transition metal di... |
41624517 | Programmable lipid nanoparticles for RNA therapeutics: Design principles and clinical translation. | RNA therapeutics have come of age as clinically validated modalities including mRNA, siRNA, antisense oligonucleotides (ASOs), and in vivo genome editing, with lipid nanoparticles (LNPs) as the main non-viral delivery system. This review defines programmable LNPs as systems whose composition and interfacial chemistry a... |
41624514 | Injectable anti-inflammatory, antioxidant supramolecular nanofiber hydrogel for peripheral nerve injury repair and neuropathic pain relief. | Patients with peripheral nerve injury (PNI) often experience neuropathic pain (NP), which is difficult to treat effectively due to ongoing inflammation and oxidative stress that impede nerve repair. Traditional anti-inflammatory antioxidants are limited by short half-lives and significant side effects. This study intro... |
41600711 | Uniqueness of Heilongjiang Mandarin Fish (<i>Siniperca chuatsi</i>): Identifying Growth-Related Functional Loci Through Whole-Genome Analysis Across Four Geographic Populations. | To analyze growth trait differences and genetic characteristics of <i>Siniperca chuatsi</i> from distinct geographic populations, whole-genome resequencing was performed on 90 samples from Heilongjiang (HLJ), Hubei (HB), Hunan (HN), and Anhui (AH), and for the first time, population-unique growth-related loci were dete... |
41599806 | Therapeutic Advances of Curcumin and Nanocurcumin in Glioblastoma: Molecular Targets, Bioavailability, and Drug Delivery. | Glioblastoma (GBM), the most common, invasive, and chemoresistant form of adult primary brain cancer, is characterized by rapid cell proliferation, local invasiveness, and resistance to chemotherapy (e.g., temozolomide (TMZ)) and radiation therapy. Curcumin, a bioactive polyphenol derived from <i>Curcuma longa</i>, has... |
41599462 | Molecular Association Between Short Linear Maltodextrin and Ferulic Acid and the Exploration of Its Applicability. | Short linear maltodextrin (SLMD) mixtures, which are modified from starch, comprise approximately 10 linear glucose molecules. In this study, we explored the noncovalent molecular association of SLMD with ferulic acid (FA) in aqueous and solid systems, as well as its applicability to water-in-oil (W/O) emulsion systems... |
41599461 | Effect of Solvent Polarity on the Photo-Induced Polymerization-Induced Self-Assembly of Poly(<i>tert</i>-butyl acrylate)-<i>block</i>-Polystyrene near Room Temperature. | Reversible addition-fragmentation chain transfer mediated polymerization-induced self-assembly (RAFT-PISA) offers an efficient approach for the preparation of polymeric nanomaterials, giving access not only to common structures such as spheres, worm-like micelles and vesicles, but also to much more complex meso-objects... |
41599450 | Sustainable Waterborne Polylactide Coatings Enabled by Hydrophobic Deep Eutectic Solvents Plasticization. | This work presents an approach to water-dispersible polylactide (PLA) particle fabrication and their application in low-temperature film formation using a combination of mechanical dispersion and ultrasonication techniques. Stable PLA dispersions were obtained after removal of surfactant and allowed for thin-film prepa... |
41599182 | Ambivalent Copper: Mechanistically Distinct Immune Effects Driving Innovation in Cancer Nanomedicine. | Copper (Cu) is an essential element required by all living cells, where it supports critical enzymatic and signaling functions. In cancer, this balance is often disrupted, creating vulnerabilities that can be therapeutically exploited. Changes in Cu availability have been shown to influence key immunoregulatory pathway... |
41599185 | New Insights into Drug Development via the Nose-to-Brain Pathway: Exemplification Through Dodecyl Creatine Ester for Neuronal Disorders. | Brain disorders remain a major global health challenge, highlighting the urgent need for innovative therapeutic strategies and efficient drug-delivery approaches. Among alternative routes, intranasal administration has garnered significant interest over recent decades, not only for its systemic delivery but also for it... |
41599041 | Iron Regulatory Mechanism IRE/IRP-like in Two Protozoa of Importance to Human Health, <i>Entamoeba histolytica</i> and <i>Giardia duodenalis</i>. | Protozoa use iron to grow, feed, and cause harm through elaborate mechanisms to obtain it from the host. In addition, expression of virulence genes is affected by iron. In <i>Entamoeba histolytica,</i> the parasite that causes amoebic dysentery and complications in human organs, our group have previously reported the p... |
41597952 | In-Situ Growth of Carbon Nanotubes on MOF-Derived High-Entropy Alloys with Efficient Electromagnetic Wave Absorption. | To obtain an excellent electromagnetic wave (EMW) absorption material, a strategy was proposed in this study with the aid of in-situ growth of carbon nanotubes (CNTs) on the surface of a metal-organic framework (MOF)-derived FeCoNiMnMg high-entropy alloy (HEA). The HEA@CNT composite was successfully prepared via a solv... |
41597649 | Review of Xylanases: Sources, Engineering and Biotechnological Use. | Xylanases (EC 3.2.1.8) are value-added enzymes essential for biomass deconstruction and are widely used in the pulp and paper, food, feed, and biofuel sectors. This review provides a comprehensive analysis of the current state and future prospects of xylanase research and application. It begins by examining the structu... |
41597180 | Decoding the lncRNA World: Comprehensive Approaches to lncRNA Structure and Interactome Studies. | Recent advances in sequencing technologies have highlighted long non-coding RNAs (lncRNAs) as key regulators that perform essential biological functions without encoding proteins. Despite growing interest, the molecular mechanisms of most lncRNAs remain poorly understood, with only a few characterized in detail. A prom... |
41596800 | Development of a pH-Responsive Delivery System Suitable for Naringenin and Other Hydrophobic Flavonoids Using the Interactions Between Basil Seed Gum and Milk Protein Complexes. | Incorporating hydrophobic flavonoids such as naringenin into food systems is challenging due to their poor water solubility and instability. Effective delivery systems are essential to improve solubility, dispersibility, and controlled release during digestion. This study developed a food-grade encapsulation system usi... |
41596273 | Catechin Augments the Antifungal Efficacy of Fluconazole Against <i>Candida parapsilosis</i>. | The rising global incidence of <i>Candida parapsilosis</i> infections is increasingly complicated by antifungal resistance, resulting in frequent therapeutic failure. This study investigated the potential of the natural compound catechin to enhance the efficacy of fluconazole through synergistic interaction. We evaluat... |
41596274 | Hyaluronic Acid-Palmitate Nanoparticle Delivery of Carbonic Anhydrase Inhibitors Impairs Growth and Early Metabolism in <i>Escherichia coli</i> Through β- and γ-Carbonic Anhydrase-Associated Processes. | Bacterial carbonic anhydrases (CAs) are essential for intracellular pH regulation, bicarbonate homeostasis, and energy metabolism, making them attractive antimicrobial targets. Here, building on evidence that acetazolamide (AZA) delivered via hyaluronic acid-palmitate (HA-PA) nanocarriers impairs <i>Escherichia coli</i... |
41596269 | Acute Dehydration Drives Organ-Specific Modulation of Phosphorylated AQP4ex in Brain and Kidney. | Water deprivation triggers coordinated physiological responses to preserve body fluid balance, yet the molecular mechanisms that regulate aquaporin-mediated water transport under dehydration remain incompletely understood. Aquaporin-4 (AQP4), the main water channel in the brain and a basolateral water pathway in the ki... |
41596267 | Camphor-10-Sulfonamide Amino Acid Esters: Synthesis, Antiviral Evaluation, and Molecular Docking Insights. | The ongoing emergence of antiviral drug resistance underscores the critical need for new broad-spectrum antiviral agents. Sulfonamides and their derivatives have emerged as promising candidates for the development of new antiviral therapeutics. In this study, a series of camphor-10-sulfonamide derivatives was synthesiz... |
41596261 | Advancements in Functional Dressings and a Case for Cotton Fiber Technology: Protease Modulation, Hydrogen Peroxide Generation, and ESKAPE Pathogen Antibacterial Activity. | The development of functionality in wound dressings has progressed since the discovery by Winter that moist wounds heal more rapidly. Approaches to incorporate functionality on several fronts of wound healing have been targeted. Here, we consider three functional features that have received increased attention for thei... |
41596264 | Influence of Aza-Substitution on Molecular Structure, Spectral and Electronic Properties of <i>t</i>-Butylphenyl Substituted Vanadyl Complexes. | Vanadyl octa-(4-<i>tert</i>-butylphenyl)phthalocyanine (<b>VOPc(<i>t</i>-BuPh)<sub>8</sub></b>) and vanadyl octa-(4-<i>tert</i>-butylphenyl)tetrapyrazinoporphyrazine (<b>VOTPyzPz(<i>t</i>-BuPh)<sub>8</sub></b>) complexes were synthesized for the first time and confirmed by IR and UV-Vis spectroscopy and MALDI-TOF spect... |
41595656 | MicroRNAs as Key Regulators in the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease: A Bioinformatics Analysis. | <b>Background:</b> Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease, is a highly prevalent hepatic condition closely linked to metabolic syndrome (MetS). Epigenetic regulators such as microRNAs (miRNAs) have emerged as critical modulators of the molec... |
41594642 | N<sup>6</sup>-Methyladenosine (m<sup>6</sup>A)-Mediated Regulation of Lipid Metabolism: Molecular Mechanisms, Pathological Implications, and Therapeutic Perspectives. | Dysregulated lipid metabolism constitutes the fundamental etiology underlying the global burden of obesity and its associated metabolic disorders. N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) is the most abundant reversible chemical modification on messenger RNA and influences virtually every aspect of RNA metabolism... |
41594362 | Protective Effects of Humic Acid on Intestinal Barrier Dysfunction and Inflammatory Activation in Canine Cell-Based Models. | The intestinal barrier is essential for gastrointestinal and systemic homeostasis by enabling nutrient absorption while limiting the translocation of pathogens and toxins. When barrier function is impaired, bacterial components such as lipopolysaccharides (LPSs) may cross the epithelium and promote inflammatory signali... |
41594369 | Integrated Single-Cell and Bulk Transcriptomics Unveils Immune Profiles in Chick Erythroid Cells upon Avian Pathogenic <i>Escherichia coli</i> Infection. | Nucleated erythroid cells (NECs) have emerged as active participants in immune responses in addition to their canonical oxygen transport function. The subpopulations and immune heterogeneity of chick erythroid cells (ch-ECs) upon infection have not been fully characterized. Single-cell RNA sequencing (scRNA-seq) was us... |
41590239 | Comparative Evaluation of the Prognostic Accuracy of IL-6 and Angiopoietin-2 for Early Severity Assessment in Acute Pancreatitis: A Systematic Review. | <h4>Background</h4>Early identification of patients at risk for severe acute pancreatitis (SAP) remains a major clinical challenge. Circulating biomarkers reflecting systemic inflammation (IL-6) and endothelial dysfunction (Ang-2) have emerged as promising tools for improving early prediction of persistent organ failur... |
41590083 | Development of the CO<sub>2</sub>-Resistant Gel by Designing a Novel CO<sub>2</sub>-Responsive Polymer for Channel Control in Low-Permeability Reservoirs. | To address the problem of serious gas channeling during CO<sub>2</sub> flooding in low-permeability reservoirs, which leads to poor oil recovery, this study developed a CO<sub>2</sub>-resistant gel using a novel CO<sub>2</sub>-responsive polymer (ADA) for gas channel control. The ADA polymer was synthesized via free-ra... |
41585741 | Preparation of Rare-Earth-Based Metal-Organic Frameworks and Their PMS Photocatalytic Activation for Rhodamine B Degradation. | Organic dyes are commonly used in the textile and leather industries and are frequently detected in natural water bodies, posing potential hazards to the ecological environment and human health. Sulfate-radical-based advanced oxidation processes (SR-AOPs) possess strong oxidation capabilities and wide pH applicability ... |
41585636 | PFDT Self-Assembled Monolayers for Stable Zinc Anodes in Aqueous Batteries. | Aqueous zinc-ion batteries (AZIBs) have emerged as important candidates for next-generation energy storage systems due to the abundance of zinc resources, high theoretical capacity (820 mAh g<sup>-1</sup>), good safety, and low cost. However, zinc dendrite growth and corrosion issues severely hinder their practical app... |
41585434 | Strategies for overcoming multiple barriers of oral administration of protein and peptide therapeutics. | Oral delivery of protein and peptide therapeutics (PPs) offers a non-invasive, patient-friendly alternative to parenteral administration, yet faces multiple formidable barriers due to the complex gastrointestinal (GI) environment. This review provides an overview of the latest advances of strategies developed to overco... |
41585738 | Silapropofol: Carbon-Silicon Isosterism in a Key Anesthetic Scaffold. | Propofol (2,6-di-<i>iso</i>-propylphenol) (<b>1</b>) is one of the most widely used intravenous anesthetics, yet its high lipophilicity, formulation challenges, and incompletely understood binding mode motivate the exploration of structural analogues. Here, we report the synthesis and comprehensive characterization of ... |
41577419 | Exogenous coreactant-free integrated ECL biosensor based on P5AIn/Fe(II)-MOF for sensitive trimethylamine N-oxide detection. | <h4>Background</h4>Trimethylamine N-oxide (TMAO) has attracted significant attention as a critical marker for seafood freshness. However, the development of integrated methods combining rapid sample pretreatment with highly sensitive detection for TMAO remains a significant gap. A novel exogenous coreactant-free integr... |
41574263 | Effects of <i>Lactobacillus paracasei</i> LK01 on production performance, egg quality, antioxidant capacity, immunity and intestinal health of laying hens. | This study aimed to evaluate the effects of dietary supplementation with <i>Lactobacillus paracasei</i> LK01 on production performance, egg quality, serum biochemical parameters, antioxidant capacity, inflammatory factors, intestinal digestive enzyme activities, and cecal microbiota in laying hens, while determining th... |
41574108 | Advances in protein-protein interaction prediction: a deep learning perspective. | Protein-protein interactions (PPIs) are vital for regulating various cellular functions and understanding how diseases are developed. The traditional ways to identify the PPIs are costly and time-consuming. In recent years, the disruptive advances in deep learning (DL) have transformed computational PPI prediction by e... |
41573741 | Pharmacophore modeling: advances and pitfalls. | Pharmacophore modeling has evolved from a static conceptual framework into a central computational tool in modern drug discovery. Recent advances include multi-pharmacophore strategies that better capture ligand diversity and target flexibility, as well as dynamic pharmacophore models ("dynophores") derived from molecu... |
41573729 | Pharmacological and bioactive properties of <i>Artemisia argyi</i> H. Lév. & Vaniot essential oil: a review. | <i>Artemisia argyi</i> H. Lév. & Vaniot Essential Oil (AAEO) is a volatile oil extracted from the leaves and stems of <i>Artemisia argyi</i>. It contains bioactive plant metabolites such as terpenes, aldehydes, ketones, alcohols, and esters. AAEO has antioxidant properties that help remove harmful free radicals and pro... |
41573726 | Mitochondrial dysfunction and apoptotic signaling induced by the combined action of 2-aminoethyl dihydrogen phosphate and methyl-β-cyclodextrin in melanoma cells. | Melanoma cells exhibit remarkable metabolic adaptability, sustained by lipid enrichment and mitochondrial resilience that enable survival under stress. Disrupting these bioenergetic and structural supports may represent an effective therapeutic avenue. This study investigated the antiproliferative, pro-apoptotic, and m... |
41573685 | Exosomes in early lung cancer diagnostics: the current state of progress made and prospects. | The high mortality rate of lung cancer primarily results from its late-stage diagnosis, at which point metastasis has usually occurred and therapeutic options are limited, leading to an overall 5-year survival rate below 20% in most countries. The current screening method, low-dose computed tomography (LDCT), faces cha... |
41573683 | The role of enamel matrix derivatives in periodontal regeneration following tooth replantation/transplantation: a narrative review of post-reperfusion injury. | <h4>Objective</h4>The autogenous tooth transplantation and tooth replantation disrupt the original dental pulp and periodontal blood supply. Pulp necrosis post-reimplantation triggered inflammatory mediator leakage through the apical foramen, which stimulated periapical osteoclast activity and subsequent resorption of ... |
41573552 | Acetylsalicylic acid disrupts SARS-CoV-2 spike protein glycosylation and selectively impairs binding to ACE2. | Preclinical and clinical evidence suggested the potential benefits of treatment with acetylsalicylic acid (ASA) in mitigating COVID-19 severity. While available studies largely focused on the intracellular pathways through which ASA impairs viral replication or dampens host immunoresponse stimulated by SARS-CoV-2, whet... |
41573311 | Recent advances in local anesthetic drug delivery systems based on natural polymers. | The core objective of pain management is to effectively alleviate pain while ensuring safety, sustainability, and personalization. Local anesthetics demonstrate significant advantages in analgesia, yet their clinical application is constrained by short half-lives and the risk of cardiotoxicity and neurotoxicity when ad... |
41573227 | <i>Taraxacum officinale</i> L. in leukemia and lymphoma: current knowledge and prospects for horticulture. | Dandelion (<i>Taraxacum officinale</i> L.) is a globally distributed medicinal plant rich in phenolic acids, flavonoids, sesquiterpene lactones and pentacyclic triterpenoids. Preclinical studies indicate that dandelion extracts and isolated constituents exert selective cytotoxic and pro-apoptotic effects against variou... |
41572966 | Metabolism, senescence, and natural products: new perspectives on wound healing in diabetes. | Chronic diabetic wounds have become a major clinical challenge because of their difficulty in healing and high recurrence rate. This review proposes for the first time the theoretical framework of the "metabolism-senescence axis," systematically elucidating the central role of cellular senescence in the mechanisms unde... |
41568098 | Machine learning for drug-target interaction prediction: A comprehensive review of models, challenges, and computational strategies. | Drug discovery is a long, resource-intensive process with high failure rates. Traditional experimental identification of drug-target interactions (DTIs) is especially time-consuming and costly. This comprehensive review examines how Artificial Intelligence (AI) and Machine Learning (ML) are transforming DTI prediction,... |
41567927 | Role of elevation of glycolysis in tumor-associated macrophages in glioblastoma immune evasion and therapeutic implications. | Glioblastoma is a highly aggressive brain cancer with significant mortality, primarily due to CD8<sup>+</sup> T cell deficiency, which obstructs effective treatment outcomes. The dysfunction and exhaustion of CD8<sup>+</sup> T cells are strongly linked to tumor-associated macrophages (TAMs), which, when exhibiting heig... |
41561463 | Stereoselective palladium-catalyzed carboetherification of cyclopropenes <i>via</i> a tethering strategy. | Highly functionalized cyclopropanes are often sought after chemical motifs as building blocks in synthetic and medicinal chemistry. However, their stereoselective synthesis using catalytic methods remains a challenge. Herein we report the first carboetherification of cyclopropenes using a palladium-catalyzed tethering ... |
41550568 | Erasable and regenerated multicomponent patterned polymer brushes. | Patterning polymer brushes represents a significantly controllable approach to surface modifications, capable of producing tailored interfacial properties. In particular, multi-component patterned polymer brushes consist of various polymer types, thereby offering enhanced versatility in surface functionalization and in... |
41550244 | Association between elevated PRIM1 expression and poor prognosis in human urothelial carcinoma. | <h4>Objective</h4>Urothelial cancer, the most frequently diagnosed cancer of the urinary tract, is the tenth most common cancer globally. DNA primase subunit 1 (PRIM1) is necessary for cancer onset and progression. PRIM1 also serves as a prognostic indicator in invasive breast carcinoma, gastric cell carcinoma, and liv... |
41539237 | Effects of dietary orange fiber supplementation on growth performance, plasma biochemical parameters, abdominal fat deposition, volatile fatty acid concentration, and cecal microbiota in 817 broilers. | Orange fiber (OGF), a byproduct of citrus juice processing, is characterized by high soluble dietary fiber and various bioactive compounds that may positively affect nutrient metabolism and intestinal health. This study investigated the effects of dietary OGF supplementation on growth performance, plasma biochemical in... |
41538945 | Long-lived photogenerated carriers enabled by S-scheme heterostructured HOF-on-hollow MOF core-shell nanoarchitectures for boosting self-powered photoelectrochemical sensor to detect enrofloxacin. | Enrofloxacin (ENR) residues in foods and the environment accelerate the spread of antimicrobial resistance, yet routine trace-level surveillance remains hindered by matrix complexity and the cost limits of conventional assays. Here, we report a self-powered, dual-photoelectrode photoelectrochemical (PEC) aptasensor tha... |
41531746 | Functional surface engineering for cultural heritage protection: the role of superhydrophobic and superoleophobic coatings - a comprehensive review. | The preservation of cultural heritage sites and objects faces critical challenges due to natural aging, environmental degradation, and human-induced damage such as vandalism and graffiti. This review article explores recent advancements in protective strategies for heritage materials including stone, concrete, ceramic,... |
41527592 | The Potential of α-Mangostin-Loaded Chitosan/Collagen Nanoparticles in Hydrogel Formulation for Enhanced Wound Healing. | <h4>Introduction</h4>Chronic and acute wounds remain difficult to manage due to the inability of conventional dressings to provide sustained delivery of poorly soluble bioactives such as α-mangostin. This study investigates the potential of α-mangostin (AMG)-loaded chitosan/collagen nanoparticles (AMG-Ch/Coll NPs) inco... |
41523267 | Development of potent, selective cPLA<sub>2</sub> inhibitors for targeting neuroinflammation in Alzheimer's disease and other neurodegenerative disorders. | Chronic neuroinflammation plays a key role in the progression of Alzheimer's disease (AD), and the cytosolic calcium-dependent phospholipase A<sub>2</sub> (cPLA<sub>2</sub>) enzyme is a critical mediator of inflammatory lipid signaling pathways. Here we investigate the therapeutic potential of novel cPLA<sub>2</sub> in... |
41522423 | Toward Scalability: Fe-MOF-Based Ultrafiltration Membrane for Effective Microplastics Removal from Drinking Water at Point-of-Use. | The frequent detection of microplastics (MPs) in bottled drinking water underscores the need for effective point-of-use (POU) purification strategies to limit human exposure, particularly given their ability to transport co-contaminants. While metal-organic frameworks (MOFs) have been extensively investigated for MP re... |
41522190 | Targeting CD44-Hyaluronic Acid Signalling in Obesity Treatment: Insights from Small Molecules and Nanobioconjugates. | Obesity is a complex metabolic disorder associated with chronic low-grade inflammation, insulin resistance, and heightened risk of comorbidities such as cardiovascular diseases and type 2 diabetes mellitus (T2DM). The Cluster of Differentiation 44 (CD44), a transmembrane glycoprotein, interacts with hyaluronic acid (HA... |
41513209 | Nucleoside-stabilized stimuli-responsive lipoic acid supramolecular hydrogel: An efficacious antioxidant and antibacterial platform for chronic diabetic wound repair. | Diabetic wound healing remains a critical clinical challenge due to persistent oxidative stress, recurrent infections, and dysregulated inflammation within the wound microenvironment. Consequently, it is desirable to develop advanced dressings capable of microenvironment-adaptive therapy to simultaneously address these... |
41513208 | A multifunctional PD-L1 modulator for metabolic reprogramming to induce pyroptosis and enhance glutamine inhibition-mediated antitumor immunotherapy. | Metabolic interference strategies offer promising interventions in tumor therapy. However, inhibiting glutamine metabolism can upregulate Programmed Cell Death Ligand 1 (PD-L1), resulting in immune evasion and limiting the efficacy of glutamine inhibitors. Here, a nano-modulator with multi-enzyme interactions, DPG@COD/... |
41513198 | Green and reagent-free synthesis of starch nanoparticles using normal corn starch via pyrolytic self-assembly method. | This study developed a pyrolytic self-assembly (PSA) method to synthesize starch nanoparticles (SNPs) from normal corn starch, addressing the scalability limitations of conventional "bottom-up" approaches that rely on chemical reagents or enzymes. The multiscale structural characteristics and self-assembly mechanism of... |
41513115 | Lipid dysregulation in renal cancer: Drivers of tumor growth and determinants of treatment-induced toxicity. | <h4>Background</h4>Clear cell renal cell carcinoma (ccRCC) exhibits a distinctive metabolic signature marked by the excessive buildup of cholesterol and neutral lipids. This phenotype stems largely from the loss of the von Hippel-Lindau (VHL) tumor suppressor and the resulting stabilization of hypoxia-inducible factors... |
41512958 | Fracture risk and treatment thresholds in patients with diabetes. | <h4>Aims</h4>Traditional risk factors underestimate fracture risk in individuals with diabetes. In this population-based case-control study we aimed to determine T-score thresholds for type 1 and 2 diabetes (T1D and T2D) with equivalent risk of fractures as that of individuals without diabetes and a T-score of -2.5.<h4... |
41512622 | Solvent extraction mechanism through ibuprofen inclusion with β-cyclodextrin revealed by dynamic interfacial tension measurement. | Dynamic interfacial tension (DIT) measurements are widely employed to investigate the adsorption kinetics of surfactants due to their high interfacial selectivity. However, their application to other interfacial processes, such as solvent extraction and interfacial chemical reactions, remains limited. In this study, we... |
41510732 | Therapeutic Implications of Nutraceutical Nanotechnology for the Treatment of Chronic Diseases. | Nanotechnology possesses therapeutic value in managing chronic disease, but it has limitations like as solubility, stability, and targeted delivery in clinical applications. The review explores how nanotechnology-based delivery systems improve the efficacy, bioavailability, and targeted actions of nutraceutical compoun... |
41510722 | Possible Thrombus-clearing Mechanism and Modification Suggestion of β-sitosterol. | <h4>Introduction</h4>Thrombin (THR) is a key therapeutic target for anticoagulant therapy, yet the mechanism of β-sitosterol, a natural compound with antithrombotic potential, remains unclear.<h4>Methods</h4>This study integrated AI-driven structural alignment, molecular docking, Molecular Dynamics (MD) simulations, bi... |
41510186 | Breast Cancer: Molecular Pathogenesis, Targeted Therapy, Screening, and Prevention. | Breast cancer is the most common cancer and the leading cause of cancer-related death among women worldwide. Advances in molecular biology, high-throughput sequencing, and integrative-omics have deepened the understanding of its heterogeneity by clarifying mechanisms linked to genetic susceptibility, epigenetic regulat... |
41510012 | Unlocking intrinsically chiral bipyrenyl-based aggregation-induced emission luminogens: circularly polarized luminescence and dynamic chirality amplification. | Understanding chiral dynamic mechanisms (from chirality generation and transfer, and amplification) is crucial for circularly polarized luminescent (CPL) materials. Herein, intrinsically chiral bipyrenyl-based enantiomers, <i>R-</i>5 and <i>S-</i>5, were first synthesized as model compounds to gain a deeper insight int... |
41509639 | Enzyme-cascade-amplified colorimetric biosensing platform for sub-nanomolar methylmercury in environmental waters. | We developed an enzyme-cascade-amplified whole-cell biosensor for sub-nanomolar methylmercury (MeHg) detection in environmental waters. By integrating a MerB-based organomercurial lyase with a water-soluble indigoidine reporter system in a decoupled genetic circuit, we achieved a limit of detection (LOD) of 0.04 nM and... |
41509638 | Tetrahydropyridines: a recent update for their multicomponent synthesis. | Tetrahydropyridines (THPs) are important nitrogen-based ring compounds found in many natural and synthetic molecules with wide biological importance. Their simple structure and chemical flexibility make them valuable in drug design and organic synthesis. Among different synthetic methods, multicomponent reactions (MCRs... |
41509577 | Bidirectional Ventricular Tachycardia Secondary to Dichloromethane Intoxication: A Case Report. | Bidirectional ventricular tachycardia (BVT) is a rare ventricular tachyarrhythmia, and only a limited number of etiologies have been described to date. We report the case of a previously healthy 30-year-old woman who developed BVT followed by cardiac arrest after accidental ingestion of dichloromethane, an organochlori... |
41509527 | Ultra-high surface area silica material and its application for selective <i>N</i>-formylation using a CO<sub>2</sub> surrogate. | A sustainable room temperature synthesis of ultra-high surface area mesoporous silica material (1653 m<sup>2</sup> g<sup>-1</sup>), designated as QSM-2, has been developed using tetraethyl orthosilicate, cetyltrimethylammonium bromide (CTAB), and β-cyclodextrin (β-CD) as the silicon source, structure directing agent, a... |
41502210 | Synthesis of <i>N</i>-Betsylated Amino Acids Using Aqueous Buffered Sodium Hypochlorite Solution. | We report a new method for the synthesis of <i>N</i>-benzo[<i>d</i>]thiazol-2-sulfonyl (Bts, betsyl)-protected amino acids, yielding building blocks amenable to solid-phase peptide synthesis (SPPS) in one step from their corresponding free amino acids. The procedure uses sodium benzo[<i>d</i>]-thiazol-2-sulfinate (sodi... |
41501811 | Cocrystal-inspired glycyrrhizic acid-azole nanoassemblies for synergistic biofilm disruption and immune modulation in fungal infections. | Fungal biofilms represent a major therapeutic hurdle due to their drug resistance and immune evasion. Here, we report a cocrystal-inspired nano-assembly strategy that co-assembles glycyrrhizic acid (GA), a natural triterpenoid saponin, with azole antifungal agents into multifunctional nanoparticles. The GA-azole co-ass... |
41501483 | Genome surveillance of SARS-CoV-2 Omicron XBB subvariants in Wuhan in June 2023. | The COVID-19 pandemic caused by SARS-CoV-2 has had a significant impact on global social and economic activities. The continuous emergence of new SARS-CoV-2 variants has made the global pandemic of COVID-19 difficult to predict. Therefore, it is of great significance to closely monitor the SARS-CoV-2 epidemic and under... |
41501454 | Albumin orchestrates a natural host defence mechanism against mucormycosis. | Mucormycosis is an emerging, life-threatening human infection caused by Mucorales fungi<sup>1-3</sup>. Metabolic disorders uniquely predispose an ever-expanding group of patients to mucormycosis through poorly understood mechanisms<sup>1,2,4,5</sup>, suggesting that uncharacterized host metabolic effectors may confer p... |
41501437 | Precision Nanotechnology: Revolutionizing Therapeutic Strategies Against Drug-Resistant Breast Cancer. | Drug resistance, which arises from a variety of biological mechanisms such as drug efflux by ATP-binding cassette transporters, epithelial-to-mesenchymal transition (EMT), the presence of cancer stem cells (CSCs), immune system evasion, and changes in the tumor microenvironment (TME), poses serious treatment challenges... |
41501359 | Genomic and transcriptomic analyses of melanoma in Japanese patients reveal candidate biomarkers for immune checkpoint inhibitor responders. | <h4>Background</h4>Immune checkpoint inhibitors (ICIs) have greatly improved advanced melanoma prognosis. However, the efficacy of ICIs in Japanese patients has been found to be lower than that in their white counterparts. We aimed to elucidate the genomic and transcriptomic features associated with response to ICIs in... |
41501243 | Molecular characterization of a novel partitivirus from quinoa (Chenopodium quinoa) in China. | A novel partitivirus was detected in quinoa (Chenopodium quinoa) plants growing in China. The complete genome sequence of quinoa cryptic virus (QCV) was determined using a combination of next-generation sequencing, RT-PCR, and RACE. Phylogenetic analysis based on amino acid (aa) sequences of the RdRP revealed that QCV ... |
41501233 | Rational design of cisplatin and carboplatin complexes for enhanced anticancer efficacy based on DFT QTAIM and docking analyses. | Cisplatin (CP) and carboplatin (CBP), two key platinum‑based anticancer drugs, face clinical limitations that prompt the search for new strategies to enhance efficacy and reduce toxicity. This study applies density functional theory (DFT), quantum theory of atoms in molecules (QTAIM), molecular docking, and spectroscop... |
41501162 | Mechanism study of circCCDC134 regulating the biological behaviors of PDGF-BB-induced oral mucosal fibroblast. | The transition of fibroblasts into myofibroblasts is a key factor in oral submucous fibrosis (OSF) pathogenesis. Our previous studies demonstrated that platelet-derived growth factor-BB (PDGF-BB) promotes the proliferation, migration, and transition of human oral mucosal fibroblasts (HOMF) by downregulating microRNA-50... |
41501129 | Targeted drug delivery to AML by OFA/iLRP aptamer guided DNA nanostructure. | Acute myeloid leukemia (AML) has relatively poor clinical outcome. The primary treatment of AML is chemotherapy, which is often associated with severe adverse effects. Targeted drug delivery is a promising strategy to reduce the adverse effects of chemotherapy. Immature laminin receptor protein (OFA/iLRP) is a potentia... |
41501077 | Computational design of dynamic biosensors for emerging synthetic opioids. | Nitazenes are an emergent class of synthetic opioids that often rival or exceed fentanyl in their potency. These compounds have been detected internationally in illicit drugs and are the cause of increasing numbers of hospitalizations and overdoses. New analogs are consistently released, making detection challenging - ... |
41501049 | Multiplexed lipid nanoparticle barcoding reveals tissue-dynamic kinetic insights and enriched cellular tropism in hepatic zones. | Lipid nanoparticles (LNPs) efficiently deliver nucleic acids to cells in vivo and facilitate clinical applications including RNA-based vaccines and therapies. Discovery and optimization of LNPs remain challenging due to the complexity of input variables and low throughput workflows. To accelerate these processes, we re... |
41501040 | Self-assembled lyotropic liquid crystal interlayer regulated interfacial polymerization for modulating structure and performance of nanofiltration membranes. | Nanofiltration (NF) is a key membrane separation technology that is promising in various chemical and environmental applications. The need for high-performance thin-film composite (TFC) NF membranes, particularly those with enhanced salt selectivity and fouling resistance, necessitates effective strategies for optimizi... |
41501039 | O-GlcNAcylation of AMFR stabilizes TSPAN4 to regulate migrasome formation for viral release. | Migrasomes are migration-dependent organelles, serving as delivery packets to mediate release of cytoplasmic contents. Tetraspanin 4 (TSPAN4) acts as a marker for migrasomes and is essential for their formation. However, the regulatory mechanism(s) underlying TSPAN4-mediated migrasome biogenesis and its physiological f... |
41501035 | Protection against lethal canine distemper virus infection by a dual epitope-targeting synthetic antibody. | Despite vaccine availability, the morbilliviruses measles virus and canine distemper virus (CDV) are still causing major health impairments in human and animal populations. Here, we identified two potent, neutralizing single domain antibodies directed against the tetrameric receptor binding (H) protein of CDV. Structur... |
41501031 | Emerging roles of tRNA modification-mediated codon-specific translational reprogramming in cancer biology. | Cancer has become a leading cause of mortality worldwide, with alarming increases in incidence and mortality rates. Emerging evidence suggests that tRNA modification enzymes play a crucial role in cancer development by modulating codon-specific translation. In this review, we focus on 18 tRNA modification enzymes and e... |
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