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41500992 | Rapid photocontrollable dopamine polymerization for instant adaptive wet adhesion. | Dopamine-based adhesives offer strong, versatile adhesion through diverse interactions but are limited by slow, poorly controlled oxidative polymerization and dopamine's inhibition of radical polymerization. We present an efficient photochemical strategy for in-situ fabrication of high-performance polydopamine-containi... |
41500933 | Highly Efficient and Selective Biosensing of Malathion Utilizing Bioengineered Nanoplatform Based on Fe<sub>3</sub>O<sub>4</sub>. | Nanobioengineered platforms have emerged as promising candidates for biosensing due to their exceptional surface properties accompanied by enhanced functionalization potential. In this research, biogenically synthesized Fe<sub>3</sub>O<sub>4</sub> nanoparticles (NPs) have been utilized to fabricate efficient biosensors... |
41500542 | Molecularly Imprinted Polymer-Based Electrogenerated Chemiluminescence Sensor for Sensitive and Selective Fentanyl Detection. | The escalating prevalence of fentanyl, a highly potent synthetic opioid responsible for rising overdose fatalities and public health crises, underscores the critical need for sensitive and selective detection methodologies. Herein, we report a molecularly imprinted polymer (MIP)-based electrogenerated chemiluminescence... |
41499715 | Monoclonal neutralizing antibodies elicited by infection with Kaposi sarcoma-associated herpesvirus reveal critical sites of vulnerability on gH/gL. | Kaposi sarcoma-associated herpesvirus (KSHV) is an oncogenic virus that causes Kaposi sarcoma, primary effusion lymphoma and multicentric Castleman disease. A vaccine that prevents KSHV infection or serves in the treatment of KSHV-related diseases represents a critical unmet need, however, the types of immune responses... |
41499685 | Bioorthogonal Molecular Turn-On Optical Imaging and Therapy. | Bioorthogonal chemistry was introduced in the context of the molecular turn-on optical imaging and therapy over 20 years. A pivotal innovation in this field is the development of bioorthogonal turn-on optical probes (BioTOPs), which integrate bioorthogonal handles with imaging agents to leverage selective bioorthogonal... |
41499632 | EnP1 exploits H2Aub-dependent epigenetic reprogramming to promote microsporidia proliferation in host cells. | Microsporidia, as opportunistic parasitic pathogens, constitute a formidable threat to human health. Although the regulatory circuitry of the nucleus-targeted effector EnP1 remains highly intricate and only partially characterized, our study identifies histone H2A as a novel binding partner of EnP1. Furthermore, we dem... |
41499627 | Structural basis for human DPP4 receptor recognition by MERS-like coronaviruses 2014-422 and GX2012. | Since its emergence in 2012, Middle East respiratory syndrome coronavirus (MERS-CoV) has posed a significant threat to human health. Recently, novel MERS-like coronaviruses with the potential for cross-species transmission have been identified. In this study, we focused on two newly isolated bat strains with putative h... |
41499542 | Dual-Functional Magnesium-Doped Zeolitic Imidazolate Framework-8 Nanoparticles for Rice Blast Control and Restoration of Magnesium-Deficient Photosynthesis. | Conventional chemical control of rice blast often leads to increased pathogen resistance and environmental challenges. Therefore, developing efficient and eco-friendly alternatives has become a key focus in rice blast management. In this study, magnesium-doped zeolitic imidazolate framework-8 nanoparticles (Mg-ZIF-8 NP... |
41499512 | The Yeh pilus adhesin is equipped with an α-helical flap motif, which contributes to pectin adherence. | The Yeh chaperone-usher pathway (CUP) pilus adhesin is encoded in one-half of all <i>Escherichia coli</i>. Yet little is known about its structure and function in <i>E. coli</i> persistence and pathogenesis. Structural investigations reveal that the adhesin receptor binding domains (RBDs) of YehD and its relative YhlD ... |
41499508 | Allospecific splenic Tr1 cells drive effector T cell exhaustion through up-regulated Areg-EGFR signaling to promote transplant tolerance. | Inducing stable tolerance to transplants remains a challenge in immunology. Previously, we induced tolerance to allogeneic islets in nonhuman primates by preemptive alloantigen delivery to antigen-presenting cells in situ. Here, mass cytometry phenotyping with incorporated donor-derived MHC-I peptide-loaded MHC-II tetr... |
41499494 | STING stimulation via supramolecular prodrug hydrogel boosts innate-adaptive immune cross-talk to prevent glioblastoma recurrence. | Glioblastoma multiforme (GBM), the most aggressive primary brain tumor, demonstrates persistent resistance to immunotherapy due to its profoundly immunosuppressive microenvironment and markedly limited T cell infiltration. In this context, we engineered a STING agonist-incorporated prodrug hydrogel that orchestrates du... |
41499463 | Asymmetric Desymmetrizing Sulfonylation of Diarylmethanes via Peptidyl-Cu(I)-Catalysis with Remote Stereocontrol. | An asymmetric catalytic desymmetrizing cross-coupling of diarylmethanes with organosulfinates has been developed. Permutations of proteinogenic and noncanonical amino acids allow access to guanidinylated peptide-based ligands that may be tuned for distal stereocontrol under copper catalysis. Noncovalent attractive inte... |
41499415 | Mechanochemical interactions in cancer cells: The role of substrate stiffness in cell behavior and drug response. | Cancer cells adhere to the extracellular matrix, where they sense and respond to variations in substrate stiffness, influencing their proliferation and invasive potential. Numerous studies have examined the biological activities of cells in relation to mechanical forces; however, research addressing the combined effect... |
41499406 | Optimizing mRNA delivery with targeted elastin-like polypeptide-based LENN formulations: Insights into the endocytosis mechanism. | Gene delivery has emerged as a groundbreaking technique for altering gene expression, offering new possibilities in treating a vast array of diseases. We report a layer-by-layer elastin-like polypeptide nucleic acid nanoparticle (LENN) system for mRNA delivery as an attractive alternative to viral vectors and lipid nan... |
41499399 | Cholesterol-containing lipid crystals can directly stiffen the rat steatotic liver before fibrosis. | Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by liver steatosis with cardiometabolic risk factors like dyslipidemia. Patients may progress from steatosis alone to complications such as fibrosis, end-stage liver disease, and hepatocellular carcinoma. The cause of progression is uncle... |
41499377 | Catalytic Enantioselective Synthesis of 1,1-Disubstituted Isochromans. | In the presence of a newly developed conjugate-base-stabilized carboxylic acid (CBSCA) catalyst, β-aryl ethanols containing a hydrogen bond donor site undergo enantioselective oxa-Pictet-Spengler reactions with ketals to provide 1-aryl,1-alkyl-isochromans in good to excellent yields and enantioselectivities. The minimi... |
41499360 | Tuning the Viscoelasticity of Supramolecular Alginate Hydrogels via Homoternary FGG-Peptide-Cucurbit[8]uril Complexes. | Cell-ECM communication plays a critical role in the correct tissue development, disease progression, and therapeutic outcomes. The interest in controlling the mechanical properties of the ECM-mimetic systems has changed from the classical concept of elastic networks to mimic the viscoelastic behavior of the native tiss... |
41499305 | Discovery of IID432 for Chagas Disease: A Cyanotriazole Inhibitor of <i>Trypanosoma cruzi</i> Topoisomerase II Achieves Sterile Cure After Short-Term Treatment in a Chronic Infection Model. | Chagas Disease is a neglected tropical disease caused by the parasite <i>Trypanosoma cruzi</i>, affecting millions worldwide. Current treatments suffer from variable efficacy, long duration, and safety concerns, highlighting the need for better therapies. A phenotypic screening of the Novartis compound library against ... |
41499078 | Advances in genetic and molecular mechanisms of crop resistance to stalk rot. | As the global warming intensifies, along with increased planting density and straw retention practices, stalk rot (SR) has become one of major diseases that negatively impacts crop yield and quality. The distribution of SR pathogens, encompassing both fungal and bacterial agents, is significantly influenced by climate ... |
41499019 | Strong and Tough MXene-Induced Bacterial Cellulose Macrofibers for AIoT Textile Electronics. | Textile electronics with extraordinary sensing capabilities holds significant potential in the Artificial Intelligence of Things (AIoT). However, little effort is paid to their mutual advantages of robust interfacial interactions, ultra-strong mechanical performance, and stability. Herein, we fabricate homogeneous and ... |
41498993 | High-Entropy Layered Hydroxides: Pioneering Synthesis, Mechanistic Insights, and Multifunctional Applications in Sustainable Energy and Biomedicine. | High-entropy layered hydroxides (HELHs), an emerging frontier in entropy-stabilized materials derived from layered double hydroxides (LDHs), have captivated attention with their unparalleled tunability, thermodynamic stability, and electrochemical performance. The integration of the high-entropy concept into LDHs empow... |
41498981 | Thermo-alkaline-activated ZrFe-MOF interface for ultrasensitive electrochemical MiRNA biosensing. | We developed a highly sensitive electrochemical sensor based on zirconium-iron metal-organic frameworks (ZrFe-MOF) for the precise detection of ultra-low abundance miRNA-21. The construction of this sensor, through an innovative thermal alkaline activation strategy, exposed abundant binding sites on the surface of ZrFe... |
41498877 | Preparation of silibinin- dendrimer-stabilized Au nanoparticles for decreasing vancomycin resistance in S. aureus clinical isolates. | <h4>Introduction</h4>Silibinin (SB), a bioactive flavonolignan derived from milk thistle seeds (Silybum marianum L.), exhibits well-documented antioxidant, antibacterial, antifungal, antiviral, and hepatoprotective activities. This study aimed to conjugate SB with fourth-generation poly(amidoamine) dendrimer-stabilized... |
41498850 | Electrochemical Detection of Organophosphates Using Dual-Modal Enzyme-Based Biosensors. | Exposure to organophosphates poses a threat to aquatic ecosystems and the public due to their acute toxicity. The dangers caused by organophosphates motivate the development of technologies for prompt detection. Therefore, engineering a portable and compact device that can monitor organophosphate vapors is vital. Elect... |
41498855 | BindFlow: A Free, User-Friendly Pipeline for Absolute Binding Free Energy Calculations Using Free Energy Perturbation or MM(PB/GB)SA. | We present BindFlow, a Python-based software for automated absolute binding free energy (ABFE) calculations at the free energy perturbation (FEP) or at the molecular mechanics Poisson-Boltzmann/generalized Born surface area [MM(PB/GB)SA] level of theory. BindFlow is free, open-source, user-friendly, and easily customiz... |
41498822 | Machine Learning Prediction of Analyte-Induced Fluorescence Perturbations in DNA-Functionalized Carbon Nanotubes. | Single-walled carbon nanotubes (SWCNTs) functionalized with single-stranded DNAs can function as near-infrared nanosensors for molecular analytes. However, predicting which analytes elicit strong optical responses for specific nanosensors remains challenging. We developed machine learning (ML) models to predict analyte... |
41498805 | Dynamic Control of DNA Origami Self-Assembly by Transcriptional Modules. | Biological cells achieve adaptive and responsive behaviors by dynamically regulating self-assembly through sensing, processing, and transmitting environmental information. Emulating this is key to engineering dynamic synthetic materials with life-like functions. In most existing dynamic self-assembly systems, the respo... |
41498795 | Ultrasensitive electrochemical sensor for HBV DNA detection based on exo III + HCR cascade amplification and label-assisted signal enhancement. | Hepatitis B virus (HBV) infection is a leading cause of cirrhosis and hepatocellular carcinoma worldwide, and HBV DNA serves as a key molecular biomarker for diagnosis and therapeutic monitoring. Accurate and ultrasensitive quantification of HBV DNA is therefore crucial for early detection and clinical management. Here... |
41498762 | Hydrogels Formed by the Self-Assembly of Collagen-Mimetic Peptides With a Constrained Backbone Structure. | Self-assembling peptides have attracted increasing attention as building blocks for developing functional materials. Among them, collagen-mimetic peptides (CMPs) represent a class of self-assembling systems. However, although short-chain CMPs spontaneously fold into thermodynamically stable triple-helical trimers, they... |
41498743 | Dual Aptamers-Based SETDB1 PROTACs as Effective Anti-Tumor Strategies for Breast Cancer. | PROteolysis TArgeting Chimeras (PROTACs) have emerged as a promising strategy for drug development targeting oncogenic proteins. Here, we report the development and characterization of dual aptamer-based PROTACs targeting SET domain bifurcated histone lysine methyltransferase 1 (SETDB1), a key epigenetic regulator impl... |
41498702 | Programmable Intermolecular Charge-Transfer Complexes for Photothermal Cancer Therapy. | Photothermal therapy (PTT) is a promising tumor treatment strategy. However, developing organic photothermal agents (PTAs) with both high photothermal conversion efficiency (PCE) and simple synthesis remains a major challenge. Herein, we developed the charge-transfer complex nanoparticles (termed PER-TCQ), via supramol... |
41498698 | Electrochemical Carbon Dioxide Reduction to Methanol on Copper-Based Catalysts: Mechanistic Insights and Industrial Prospects. | Electrochemical CO<sub>2</sub> reduction (ECO<sub>2</sub>R) offers a promising route to convert CO<sub>2</sub> into high-value-added chemicals using renewable energy. Among the diverse ECO<sub>2</sub>R products, the selective conversion of CO<sub>2</sub> to methanol (CH<sub>3</sub>OH) holds significant industrial impor... |
41498690 | Unsupervised Hierarchical Symbolic Regression for Interpretable Property Modeling in Complex Multi-Variable Systems. | Recent advances in artificial intelligence have produced powerful predictive models for chemical analysis, but model interpretability remains a challenge. Here, we introduce Unsupervised Hierarchical Symbolic Regression (UHSR), providing an explainable solution while maintaining competitive predictive performance. With... |
41498699 | Ultrasensitive Electrochemical Biosensor for DNA Methylation Detection Based on Fe-MOF/PANI and Catalytic Hairpin Assembly Cascade Reaction. | DNA methylation, as an important epigenetic modification, is closely related to gene expression regulation and cancer development. This study developed a new electrochemical biosensor for ultrasensitive detection of DNA methylation based on the combination of Fe/metal-organic framework (MOF)/polymer polyaniline (PANI) ... |
41498686 | Fully Automated Inverse Co-Optimization of Templates and Block Copolymer Blending Recipes for Directed Self-Assembly Lithography. | The directed self-assembly (DSA) of block copolymers (BCPs) offers a highly promising approach for the fabrication of contact holes or vertical interconnect access at sub-10 nm technology nodes. To fabricate circular nanoholes with precisely controlled size and positions, the self-assembly of block copolymers requires ... |
41498662 | A quiet but growing threat: Global perspectives on antifungal resistance and future therapeutic approaches. | <h4>Abstract</h4>Antifungal drug resistance is an escalating global health concern that threatens the effective treatment of fungal infections in both clinical and environmental settings. This review synthesizes developments, focusing on molecular and physiological mechanisms of resistance, key contributing factors, an... |
41498664 | Outer membrane protein LipL21 as a potential candidate against Leptospira interrogans: An in silico prediction. | <h4>Abstract</h4>Leptospirosis is one of the most widespread zoonotic diseases caused by Leptospira interrogans, characterized by mild febrile illness to severe multiorgan failure. The conventional vaccines against Leptospira have several drawbacks, including short-term immunity and serovar-based protection. The curren... |
41498647 | Stimuli-Responsive Supramolecular Biomaterials for Cancer Theranostics. | The ultimate goal of cancer theranostics is to deliver imaging agents and therapeutic cargo to tumor sites when and where they are required. "Smart" systems─including targeted and tailored releases with excellent spatial, temporal, and dosage control─should be developed. Supramolecular interactions with dynamic, revers... |
41498572 | Dynamic Order-Disorder Conversions of Specific Facets in a Metal-Organic Framework: Chemically Reversible Iodine-Immobilization for Sodium-Iodine Batteries. | Sodium-iodine batteries offer high voltage and theoretical capacity but suffer from iodine dissolution, shuttle effect, and sluggish kinetics. This work develops a porous Cu/Ni-Mo metal-organic framework (MOF) formulated as Cu<sup>II</sup>Ni<sup>II</sup>(4,4'-bpy) (Mo<sup>VI</sup>O<sub>4</sub>)<sub>2</sub> (4,4'-bpy = ... |
41498448 | Theory-Guided Discovery of Ion-Exchanged Poly(heptazine imide) Photocatalysts Using First-Principles Many-Body Perturbation Theory. | Poly(heptazine imides) (PHI) show strong promise in photocatalysis, but limited control over electronic properties continues to constrain their full potential. We modulated PHI's photocatalytic activity to overcome this limitation by incorporating mono-, di-, and trivalent metal cations into its framework. We employed ... |
41498425 | Discovery of a Piperazine-Based Quaternary Ammonium Macrocycle as a Universal Reversal Agent for Heparin Anticoagulants. | The development of a biocompatible antidote that can efficiently neutralize the anticoagulation activity of both unfractionated heparin (UFH) and low-molecular-weight heparins (LMWHs) represents an unmet medical need. Here, we report that a piperazine-derived tetracationic macrocycle can efficiently neutralize both UFH... |
41498366 | Surface-Attached Model Lipid Membranes Derived from Human Red Blood Cells. | Red blood cells (RBCs) are the most abundant human cell type, and interactions with the RBC membrane are at the heart of many processes relevant for human health, such as immune system modulation, as well as binding by foreign pathogens and pharmacological drugs. To better study such membrane interface interactions, it... |
41498316 | SSZ-13 Zeolite with Isolated Co<sup>2+</sup> Sites as an Efficient and Durable Catalyst System for Non-Oxidative Ethane Dehydrogenation. | Non-oxidative dehydrogenation of ethane (EDH) is an attractive method for on-purpose ethene production, but achieving high activity and, especially, durability with catalysts based on earth-abundant metals remains challenging. Herein, we introduce the Co/SSZ-13 system with exclusively divalent cobalt (Co<sup>2+</sup>) ... |
41498248 | Click-Enabled Grafting for Adaptive Chiral Recognition in Porous Crystals. | Reticular frameworks are promising candidates for chiral environments, yet most rely on static stereogenic units, overlooking adaptive host-guest interactions in enantioselective recognition. We report a modular postsynthetic click strategy to install amino acid-derived peptidic moieties into UiO-68 frameworks without ... |
41498194 | Materials and System Design for Self-Decision Bioelectronic Systems. | Self-decision bioelectronic systems mark a transformative leap from conventional 'sense-then-treat' paradigms toward autonomous, closed-loop therapeutics, with material innovation serving as the pivotal enabler. This review posits that material innovation is the pivotal enabler of this transition, seamlessly integratin... |
41498191 | Cation-Dependent Multilayered Host-Guest Assemblies Formed by a Xanthene-Based Dinuclear Nickel(II) Macrocycle. | A planar bis(saloph) nickel(II) macrocyclic host, L<sup>2b</sup>Ni<sub>2</sub>, incorporating xanthene motifs and hexyl side chains, was synthesized to provide structural rigidity and solubility. Its ion recognition behavior toward alkali metal ions was investigated by <sup>1</sup>H NMR titration, mass spectrometry, an... |
41498197 | Conductive Hydrogels: Progress and Prospects in Biomedical Engineering. | Conductive hydrogels (CHs), which integrate the biomimetic properties of hydrogels with the functionality of conductive components, have demonstrated distinctive advantages in biomedical engineering. By modulating cell-cell interactions, CHs provide an optimal microenvironment to facilitate cellular growth, proliferati... |
41498178 | Sculpting the Future of Bone: The Evolution of Absorbable Materials in Orthopedics. | The repair of bone defects remains a major clinical challenge, as autologous grafts are constrained by donor limitations and bioinert implants often necessitate secondary surgeries. Absorbable materials, including polymers, ceramics, and metals, are rapidly transforming orthopedic care by offering temporary support and... |
41495845 | IL-27 signaling mediates skin inflammation in experimental psoriasis and atopic dermatitis. | <h4>Background</h4>Psoriasis and atopic dermatitis (AD) are two prevalent inflammatory skin disorders, each characterized by distinct adaptive immune responses. However, recent evidence suggests that these diseases may share overlapping immune mechanisms, especially concerning keratinocyte function. The specific cytoki... |
41495822 | Microbial modulators of the epigenome: probiotic regulation of MiRNAs and LncRNAs in health and disease and preventive medicine. | Current improvements in microbiome research have illuminated the serious function of probiotics in modulating host gene expression through epigenetic mechanisms, particularly via the regulation of non-coding RNAs (ncRNAs) such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs). These regulatory RNAs are essential... |
41495814 | Danggui-Shaoyao-San modulates sphingolipid metabolism to promote oligodendrocyte differentiation and maturation in vascular dementia rats. | <h4>Objective</h4>Vascular dementia (VaD) is a neurodegenerative disease primarily characterized by white matter injury and myelin degeneration, and currently, there is a lack of effective treatment options. This study aims to investigate the effects of the traditional Chinese medicine formula Danggui Shaoyao San (DSS)... |
41495819 | Zhimu-Huangbai codecoction for the treatment of type II diabetes mellitus through its self-assembling nanoparticles. | Traditional Chinese medicine (TCM) decoctions represent a complex system comprising multiple phases, and their therapeutic effects cannot be fully elucidated solely at the molecular level. The nanophase within TCM decoctions plays a significant role in mediating their pharmacological activities. Zhimu and Huangbai herb... |
41495462 | RRx-001 ameliorates astrocyte pyroptosis by regulating LCN2-NLRP3 inflammasome activation in an MPTP-induced parkinson's disease mouse model. | Parkinson's disease (PD) is characterized by progressive neurodegeneration closely linked to neuroinflammation and oxidative stress-induced damage and is characterized by the loss of dopaminergic (DAergic) neurons and the inflammatory response associated with glial cells. RRx-001 (RRx, 2-bromo-1-(3,3-dinitroazetidin-1-... |
41495421 | Roles of cytoskeleton in metastasis: from its mechanism to therapeutic strategies. | The cytoskeleton is a dynamic intracellular protein network composed of actin filaments, microtubules and intermediate filaments that provides structural support in cells and plays a crucial role in tumor metastasis. Tumor cells encounter various dynamic mechanical environments during metastasis, and they adapt to thes... |
41495363 | Advances in natural product discovery: strategies, technologies, and insights. | Natural products (NPs) and their analogues have long underpinned therapies in humans, animals, and plants health, yet, discovering truly novel scaffolds remains a formidable challenge, even with the enormous diversity offered. Over the last two decades, breakthroughs in bioinformatics, cheminformatics, advanced analyti... |
41495339 | Visible-light Cr(VI) reduction on a CdS@MOF@C<sub>3</sub>N<sub>4</sub> heterostructure via cascade S-scheme mechanism: a comprehensive study. | A ternary CdS@MOF@C<sub>3</sub>N<sub>4</sub> nanocomposite was synthesized and evaluated as a visible-light-driven photocatalyst for the reduction of hexavalent chromium (Cr(VI)). Structural and spectroscopic analyses (XRD, FTIR, TEM, FESEM-EDS, TGA, BET, PL, UV-Vis DRS) confirmed the successful integration of CdS and ... |
41495258 | Advances and strategies in biosensor-based diagnostics for parasitic infections: a comprehensive scoping review. | Parasitic diseases are among the most widespread infections worldwide, causing millions of deaths and illnesses each year. So rapid and accurate diagnosis is essential, requiring highly sensitive and specific tests. Biosensors can provide significant advantages over traditional diagnostic methods because of their speci... |
41495069 | Refrigeration down to 0.16 K using a frustrated magnet Gd<sub>2</sub>B<sub>2</sub>MoO<sub>9</sub>. | Magnetic refrigeration, utilizing the magnetocaloric effect in solid-state magnets, has emerged as a promising cooling technology. The development of practical ultra-low-temperature magnetic refrigeration applications has been limited by the absence of high-performance magnetic refrigerants. Herein, we provide a frustr... |
41495048 | Breaking barriers in prostate cancer: the mRNA vaccine breakthrough and what comes next. | Prostate cancer (PC) treatment is evolving beyond conventional therapies. This review explores mRNA-based vaccines as a promising immunotherapy. We discuss their mechanism of action, advantages in production and safety, and results from early clinical trials (e.g., CV9103/4). Key challenges like antigen selection and t... |
41457671 | Construction of albumin-based nanoparticles utilizing paclitaxel-fatty acid prodrug that mimicking the natural fatty-acid binding process <i>in vivo</i> to synergistically elevate ROS with β-lapachone for cooperative cancer therapy. | <h4>Objective</h4>The aim of this study was to develop a chemotherapy drug paclitaxel (PTX) and a tumor-specific ROS generation agent β-lapachone(LAP) co-loaded human serum albumin (HSA)-based nanoparticles (ANPs) for synergistic anticancer therapy.<h4>Significance</h4>Albumin-based nanoparticles (ANPs) offer unique ad... |
41363952 | Buchwald-Hartwig aminated pyrene-heterocycles with host-guest-enhanced NIR phosphorescence: DFT-guided design toward breast cancer imaging probes. | Organic near-infrared room-temperature phosphorescent (NIR-RTP) materials face fundamental challenges from the energy gap law, limiting emission efficiency of wavelengths >600 nm and long-lived triplet states. We report the rational design of Buchwald-Hartwig aminated pyrene-heterocycles embedded in benzophenone host m... |
41362217 | Mechanisms and regio- and stereoselectivities in NHC-catalyzed [3+3] annulations for the synthesis of axially and centrally chiral dihydropyridinones. | Organocatalytic annulation strategies serve as an ideal approach for constructing molecules integrating both axial and central chirality, yet theoretical studies on the origin of stereoselectivity remain insufficient. In this study, the NHC-catalyzed [3+3] annulation between cinnamaldehyde and 2-aminomaleate was system... |
41355721 | Dissecting the single-electron C-C bond: NBO and AIM perspectives. | In this work, we present a comprehensive electronic structure analysis of the highly praised oxidation product of tricyclic compound spiro-dibenzocycloheptatriene (1p), with emphasis on characterizing the nature of the non-covalent interaction between <i>ipso</i> carbon atoms (C1 and C2), which has been characterized a... |
41347562 | Dynamic self-shrinking peptide hydrogels with shape memory and self-healing properties. | Three peptide amphiphiles based on aromatic amino acids have been successfully synthesized, purified, and thoroughly characterized. These peptides were found to form hydrogels at physiological pH 7.46, exhibiting a unique time-dependent self-shrinking behaviour. Notably, the extent and nature of this self-shrinking var... |
41347484 | Tuning enantioselective drug adsorption in isoreticular homochiral metal-peptide frameworks through proximity pore interactions. | Pharmaceutical research emphasizes stereochemistry and the enantioseparation of racemic drugs because different enantiomers can exhibit varying pharmacological and toxicological properties when interacting with the body's metabolic pathways. Metal-organic frameworks (MOFs) are porous adsorbents that can be designed to ... |
41347482 | Multicolor cyanine dendritic dots for real-time, high-resolution tracking of nanoparticle biodistribution. | Fluorescence imaging has become a powerful tool for visualizing nanoparticles in drug delivery systems, and multicolor fluorescence imaging offers an intuitive approach to exploring complex biological systems. Here, we present multicolor cyanine-based polylysine (PLL) dendritic dots (Cy3/Cy5/Cy7-PLL; up to eight genera... |
41347431 | Transition metal-free organocatalyzed direct <i>N</i>-benzylation of amides <i>via</i> a hydrogen borrowing strategy. | The development of a versatile methodology for the <i>N</i>-benzylation of amides is challenging due to the relatively poor nucleophilicity of the amide nitrogen. Herein, we report the first transition metal-free, broad catalytic methodology for the <i>N</i>-benzylation of amides using alcohols <i>via</i> a hydrogen bo... |
41311051 | Insights on the binding and selectivity of surfen towards different DNA topologies. | Surfen is widely recognized for its anticoagulant properties in clinical applications. Recent interest, however, has shifted toward exploring its potential interactions with DNA, which may pave the way for novel therapeutic strategies, particularly in areas where regulation of DNA structure and function is critical. In... |
41647252 | Toward the Chemoenzymatic Synthesis of DNA-Encoded Libraries. | DNA-encoded libraries (DELs) have become a powerful platform in drug discovery, practiced both by the pharmaceutical industry and academia. Each small molecule contained in a DEL is covalently linked to a DNA tag which serves as an amplifiable barcode facilitating binder identification. However, the chemical diversity ... |
41624508 | Nanomaterial-enabled rheumatoid arthritis treatment: An advanced investigation into photonic - acoustic - gaseous multimodal therapy. | Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease. Current treatments mainly involve drugs and surgery, but face limitations like adverse effects, invasive complications, and poor outcomes. Emerging nanomaterial-mediated modalities, particularly photothermal therapy (PTT), photodynamic therapy (PDT), p... |
41623476 | Pharmacological perturbation of splicing elicits SMG1 reduction: Implications for cancer therapy. | Nonsense-mediated mRNA decay (NMD) is an RNA quality control pathway that degrades transcripts containing premature termination codons (PTCs). While the role of NMD in modulating tumor antigenicity and immune evasion is increasingly appreciated, its interaction with splicing remains poorly understood. We uncover a mech... |
41601090 | Metal-organic framework-hybridized immobilized laccase for the efficient degradation of industrial wastewater pollutants. | Natural laccases from Lentinula edodes exhibit remarkable catalytic versatility in degrading various organic pollutants in industrial wastewater. However, their practical applications are limited by their inherent structural instability and poor reusability. To address these limitations, we designed a robust hybrid bio... |
41599447 | Asymmetric Isoporous Membranes of 2-Vinylpyridine-Styrene Linear Diblock Copolymers: Fabrication and Evaluation in Water Treatment. | Herein, we report the synthesis via controlled reversible addition-fragmentation chain transfer (RAFT) polymerization of amphiphilic 2-vinylpyridine-<i>b</i>-styrene (2VPy-<i>b</i>-Sty) diblock copolymers of high molar masses (range: 52,100-304,000 g mol<sup>-1</sup>) and various compositions (range: 2VP content 11.6-5... |
41599448 | Engineered GO-Based Hydrogels for Controlled Hyaluronic Acid Release in Knee Osteoarthritis Treatment. | Osteoarthritis (OA) is a prevalent chronic pain syndrome and a leading cause of disability worldwide, characterized by progressive deterioration of articular cartilage. This degradation leads to pain, swelling, inflammation, and eventual stiffness as the cartilage wears down, causing bone-on-bone friction. Current medi... |
41599251 | Mechanistic Pathways and Product Selectivity in Pyrolysis of PE, PP and PVC: A Foundation for Applied Chemistry in Europe. | Plastic streams dominated by polyethylene (PE) including PE HD/MD (High Density/Medium Density) and PE LD/LLD (Low Density/Linear Low Density), polypropylene (PP), and polyvinyl chloride (PVC) across Europe demand a design framework that links synthesis with end of life reactivity, supporting circular economic goals an... |
41599180 | Recent Developments in Protein-Based Hydrogels for Advanced Drug Delivery Applications. | Protein-based hydrogels are increasingly recognized as promising biomaterials for advanced drug delivery, owing to their biocompatibility, biodegradability, and ability to recreate extracellular matrix-like environments. By tailoring the protein source, crosslinking strategy, molecular architecture, and functionalizati... |
41598369 | T-LysYal for Managing Dry Eye Disease, the Advent of Supramolecular Aggregates in Ophthalmology: A Narrative Review. | Dry Eye Disease (DED) is a highly characterised multifactorial disease resulting in the loss of tear film homeostasis and associated with a major impact on patient quality of life. DED affects up to half of the global population, with modern lifestyle factors playing a critical role in disease development, particularly... |
41597171 | Mitochondria and Epigenetic Regulation: Bidirectional Crosstalk and Emerging Mitochondria-Targeted Degron Tools. | Mitochondria not only generate ATP and metabolites essential for nuclear and cytoplasmic processes but also actively shape nuclear epigenetic regulation. Conversely, the nucleus encodes most of the proteins required for mitochondrial functions, and intriguingly, certain nuclear-encoded epigenetic factors-such as DNA an... |
41596243 | Research Advances in Bionic Cell Membrane-Mediated Nanodrug Delivery Systems for the Treatment of Periodontitis with Osteoporosis. | With the intensification of global population aging, the co-morbidity rate of periodontitis and osteoporosis has significantly increased. The two are pathologically intertwined, forming a vicious cycle characterized by bone immunoregulatory dysfunction in the periodontal microenvironment, abnormal accumulation of react... |
41596236 | CPP-PNA Conjugate-Mediated Inhibition of <i>pdxA</i> Gene Impairs Vitamin B6 Biosynthesis and Growth in <i>Acinetobacter baumannii</i>. | <i>Acinetobacter baumannii</i> represents a critical-priority organism due to its multidrug resistance. The emergence of carbapenem-resistant strains poses a major clinical challenge, underscoring the urgent need for novel antibacterial agents with alternative mechanisms. As peptide nucleic acids (PNAs) have recently g... |
41596233 | A Comprehensive Physicochemical Analysis Focusing on the Characterization and Stability of Valsartan Silver Nano-Conjugates. | Valsartan (Val)-a lipophilic non-peptide angiotensin II type 1 receptor antagonist-is highly effective against hypertension and displaying limited solubility in water (3.08 μg/mL), thereby resulting in low oral bioavailability (23%). The limited water solubility of antihypertensive drugs can pose a challenge, particula... |
41596214 | Photocontrol of Non-Adherent Cell Adhesion via Azobenzene-PEG-Lipid/Cyclodextrin Host-Guest Interactions. | Controlling cell attachment to substrates with spatiotemporal precision is a key technological foundation in fields such as tissue engineering, cell sorting, and cell-cell interaction analysis. Among existing approaches, azobenzene-based photocontrollable systems offer a promising strategy for the reversible regulation... |
41596131 | Oxidative Stress and Lysosomal Dysfunction in Neurodegenerative Diseases: Underlying Mechanisms and Nanotherapeutic Targeting Strategies. | Neurodegenerative diseases (NDDs), defined by the progressive loss of neurons, present a major challenge to global health. Oxidative stress and lysosomal dysfunction are both key pathogenic factors in NDDs, and they do not operate in isolation; instead, the vicious cycle they form, often mediated through organellar cro... |
41595654 | Analysis of Pharmacokinetic and Pharmacodynamic Interactions Between Chlorpromazine and Risperidone via Simultaneous Measurement of Multiple Receptor Occupancy in the Rat Brain. | <b>Background/Objectives:</b> Combination therapy for schizophrenia may exacerbate side effects mediated by multiple brain receptors. This study aimed to elucidate the pharmacodynamic and pharmacokinetic interactions between chlorpromazine and risperidone. We investigated dopamine 2 (D<sub>2</sub>), serotonin 2A (5-HT<... |
41595108 | Implementation of Natural Products and Derivatives in Acute Myeloid Leukemia Management: Current Treatments, Clinical Trials and Future Directions. | Bioactive natural products (NPs) may play a critical role in cancer progression by targeting nucleic acids and a wide array of proteins, including enzymes. Furthermore, a large number of derivatives (NPDs), including semi-synthetic products and pharmacophores from NPs, have been developed to enhance the solubility and ... |
41594157 | The Relationship Between Bone Health Status of Post-Menopausal Women with Non-Functional Adrenal Tumours/Mild Autonomous Cortisol Secretion and Their Baseline Morning Adrenocorticotropic Level. | <b>Background</b>. Glucocorticoid-induced osteoporosis represents a well-known type of secondary osteoporosis (SOp). While the most prevalent sub-category includes corticotherapy, another important contributor is represented by Cushing's syndrome. In this traditional landscape, adrenal incidentalomas do not involve a s... |
41591173 | Environmental and Regulatory Control of RTX Toxins in Gram-Negative Pathogens. | Repeat-in-toxin (RTX) toxins are calcium-dependent exoproteins secreted by diverse Gram-negative bacteria and play central roles in cytotoxicity, immune modulation, and tissue colonization. While their structure and secretion mechanisms are well-characterized, the regulation of RTX toxin expression remains complex and ... |
41585716 | Bilayer-Coated Magnetite Nanoparticles as Magnetic Adsorbents for Efficient Paraquat Removal. | The environmental persistence and acute toxicity of paraquat (PQ<sup>2+</sup>) highlight the urgent need for efficient and reusable adsorbents for water remediation. In this study, linoleic acid (LA)- and palmitic acid (PA)-coated magnetite nanoparticles (Fe<sub>3</sub>O<sub>4</sub>@LA and Fe<sub>3</sub>O<sub>4</sub>@P... |
41585664 | Optimizing Molecular Descriptors for Reliable Adsorption Energy Prediction on Transition Metal Nanoclusters. | Efficient catalytic processes are crucial for converting pollutant molecules into valuable products. Transition-metal nanoclusters show promise as a result of their tunable properties, but identifying active catalysts requires costly studies of the adsorption energetics. Machine learning offers a faster alternative, pr... |
41585652 | Light-Induced Manipulation of Circularly Polarized Luminescence Color and Intensity via the Photonic Bandgap Effect. | The development of smart circularly polarized luminescence (CPL) systems with dynamically tunable emission properties presents both a significant challenge and a compelling opportunity in advanced photonics. Herein, we report a light-responsive CPL system fabricated by dispersing achiral Coumarin 6 and a photochromic s... |
41585649 | Engineering Superparamagnetic Fe<sub>3</sub>O<sub>4</sub>@Mg-MOF-74 for Advanced CO<sub>2</sub> Capture Application. | This research discusses a novel approach to reduce the demanding regeneration phase in the carbon dioxide adsorption process. Through the employment of the magnetic induction swing adsorption technology, in situ heating adsorbents were developed, which were responsive to the induced magnetic field. The novel material, ... |
41585635 | Paramagnetic Properties of Rare Earth Hydroxides, Oxalates, and Dibutyl Phosphates. | Magnetic separations present a promising approach for the recovery of rare earth (RE) elements from mixtures, particularly when coupled with precipitation techniques that enhance process efficiency and selectivity. However, the magnetic properties of RE materials typically encountered in the separations industry are no... |
41585567 | Interaction mechanisms in cassava starch-hemicellulose-sinapic acid ternary complex. | This research explores the mechanisms underlying the interactions within the cassava starch (CS)-hemicellulose (HE)-sinapic acid (EA) ternary complex. The results demonstrate that CS, HE, and EA predominantly form a ternary complex through hydrogen bonding and hydrophobic interactions. Specifically, HE intertwines with... |
41585566 | Hydrogel-based systems with nanoparticle and microencapsulation for food preservation: Preparation, characterization, and application. | Global food spoilage, driven by microbial growth and oxidative deterioration, necessitates advanced preservation strategies. This study systematically reviews the preparation methods, structural and functional characterization, and applications of these hybrid systems across dairy, fruit, and meat products. The incorpo... |
41585443 | Antithrombotic and antibacterial surface coating based on spiky silver nanoparticles: A counterattack against clotting and biofilm. | Blood-contacting medical devices such as vascular grafts, stents, and catheters are indispensable in life-saving interventions but remain prone to thrombosis and bacterial infection. These complications are often synergistic, with clot formation facilitating bacterial colonisation and biofilm growth, yet most surface c... |
41585651 | Transforming Coagulation Testing: The Role of Biosensors in Prothrombin Time (PT) Measurement. | A key component of blood coagulation evaluation, prothrombin time (PT) measurement is used to diagnose clotting abnormalities, track anticoagulant treatments, and evaluate liver function. Despite their clinical significance, traditional PT testing techniques frequently depend on centralized laboratory setups, which can... |
41568225 | Innovations in collagen-network remodeling and extracellular matrix mechanics: toward a new era in articular cartilage repair. | Articular cartilage is a highly specialized connective tissue with a hierarchically organized extracellular matrix (ECM) that provides the mechanical resilience necessary for joint function. Central to this functionality is the depth-dependent architecture of collagen-primarily type II-interwoven with proteoglycans, en... |
41568040 | Magnesium modulates the stress responses of oral streptococci to environmental and antibiotic challenges by altering cell envelope and nutrient transport pathways. | <h4>Background</h4>Magnesium (Mg<sup>2+</sup>) is one of the most abundant metals in human teeth, second only to calcium. Demineralization of the tooth, caused by sugar intake or acid reflux, releases Mg<sup>2+</sup> into the saliva. Mg<sup>2+</sup> is also recommended as a dietary supplement for the prevention and tre... |
41567982 | Neoantigens in cancer immunoediting: from mechanisms to personalized vaccines in breast cancer. | Tumor neoantigens, a class of entirely novel antigens generated by somatic mutations, can be specifically recognized by T cells and serve as a central bridge connecting tumor genomic variation with anti-tumor immune responses. This review systematically elaborates on the dual role of neoantigens in the dynamic process ... |
41567977 | Construction and application of pancreatic exocrine organoid and spheroid for drug screening and precision medicine. | The incidence of pancreatic exocrine disorders, particularly pancreatic cancer, has been steadily rising. However, treatment options remain limited, with substantial interindividual variability in therapeutic efficacy. This clinical challenge has accelerated the development of advanced three-dimensional (3D) modeling s... |
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