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41600000 | Stress-Induced Plant Specialized Metabolism: Signaling, Multi-Omics Integration, and Plant-Derived Antimicrobial Metabolites to Combat Antimicrobial Resistance. | Antimicrobial resistance (AMR) is one of the major health threats of the 21st century and demands innovative sources of bioactive compounds. In 2019, infections caused by resistant bacteria directly accounted for 1.27 million deaths and contributed to an additional 4.95 million associated deaths, underscoring the urgen... |
41599712 | Blocking ASIP to Protect MC1R Signaling and Mitigate Melanoma Risk: An In Silico Study. | <b>Background:</b> Melanin protects skin and hair from the effects of ultraviolet (UV) radiation damage, which contributes to all forms of skin cancer, including melanoma. Human melanocytes produce two main types of melanin: eumelanin provides effective photoprotection, and pheomelanin offers less protection against UV... |
41599713 | Chrysin and Luteolin from Moroccan Propolis to Prevent Aggressive Periodontitis Caused by <i>Aggregatibacter actinomycetemcomitans</i> Leukotoxin: A Computer-Aided Drug Design Approach. | <b>Background</b>: <i>Aggregatibacter actinomycetemcomitans</i> is a Gram-negative, facultative anaerobic, immobile oral bacterium responsible for the secretion of virulence factors, namely leukotoxin (LtxA), a large exotoxin of the RTX family that enables the bacterium to evade the immune system by destroying leukocyt... |
41599467 | Bio-Based Pectin-Calcium Film and Foam Adsorbents with Immobilized Fe-BTC MOF for Water Contaminant Removal. | Metal-organic frameworks (MOFs) offer high porosity for water remediation but face challenges in handling as powders. We address these limitations by physically immobilizing Fe-BTC MOF within calcium-crosslinked low-methoxyl pectin matrices (PE-Ca-MOF). Solvent-cast films and freeze-dried foams were fabricated using wa... |
41599466 | Pentamidine-Functionalized Polycaprolactone Nanofibers Produced by Solution Blow Spinning for Controlled Release in Cutaneous Leishmaniasis Treatment. | Leishmaniasis, a widespread, neglected infectious disease with limited effective treatments and increasing drug resistance, demands innovative therapeutic approaches. In this study, we report the fabrication of pentamidine (PTM)-loaded polycaprolactone (PCL) nanofibers using solution blow spinning (SBS) as a potential ... |
41599273 | Procyanidins: Structural Properties, Production Methods, and Modern Applications. | Procyanidins, a class of substances widely distributed in nature, have attracted the attention of the scientific community due to their bioactive properties, especially with regard to human health. This review is based on an extensive examination of peer-reviewed literature, patents, and clinical trial reports publishe... |
41599264 | Synthesis and Photocatalytic Evaluation of CoPc/g-C<sub>3</sub>N<sub>4</sub> and CuPc/g-C<sub>3</sub>N<sub>4</sub> Catalysts for Efficient Degradation of Chlorinated Phenols. | The oxidation of chlorophenolic compounds is essential for converting these persistent and toxic pollutants into less harmful products, thereby reducing their environmental and health impacts. In this study, a p-coumaric acid ester derivative was employed as the starting material to synthesize the corresponding phthalo... |
41597965 | Study on the Immobilization of Horseradish Peroxidase on a Multi-Level Composite Carrier SiO<sub>2</sub>@MnO<sub>2</sub>@MAF-7. | This study addresses the issues of poor stability and difficulty in recovery of free horseradish peroxidase (HRP) by developing a multi-level composite immobilized carrier that combines high loading capacity with long-term stability. The SiO<sub>2</sub>@MnO<sub>2</sub>@MAF-7 core-shell structured carrier was prepared v... |
41597661 | Oral Dysbiosis and Neuroinflammation: Implications for Alzheimer's, Parkinson's and Mood Disorders. | <h4>Background</h4>Growing evidence indicates that oral microbiome dysbiosis contributes to systemic inflammation, immune activation, and neural dysfunction. These processes may influence the onset and progression of major neuropsychiatric and neurodegenerative disorders. This review integrates clinical, epidemiologica... |
41596825 | Nanoparticles for Synergistic Delivery of Curcumin and Quercetin Based on Zein and Sodium Caseinate: Preparation, Characterization, and Intestinal Absorption. | The purpose of the study was to characterize the basic structure of nanoparticles (Zein-CS-Cur-Que) embedded in curcumin and quercetin, realize the synergistic antioxidant of dietary polyphenols, and improve the transmembrane transport rate and bioavailability of curcumin. The oral delivery system Zein-CS-Cur-Que devel... |
41596816 | Metabolomics and Transcriptomics Analyses Explore the Genes Related to the Biosynthesis of Antioxidant Active Ingredient Isoquercetin. | <i>Astragalus membranaceus</i> is a model of traditional 'homologous nature of medicine and food'. Its stems and leaves have been proven to have a variety of biological activities. In this study, high-throughput sequencing technology was used to sequence transcriptomics and metabolomics <i>A. membranaceus</i> stems and... |
41596304 | One Health Insights into <i>Enterococcus</i>: Antimicrobial Resistance and Virulence in Companion Animals and Their Tutors. | <i>Enterococcus</i> spp. are opportunistic pathogens and commensals in humans and animals and are widely used as indicators of bacterial exchange, providing insights into antimicrobial resistance (AMR) and virulence dissemination within the One Health continuum. <i>Enterococcus</i> from healthy companion animals and th... |
41596305 | Biological Roles of Melanin and Natural Product-Derived Approaches for Its Modulation. | Melanin produced in melanocytes contributes to photoprotection, oxidative stress reduction, immune regulation, and epidermal homeostasis, while its dysregulation underlies diverse pigmentary disorders. Natural products modulate melanogenesis by regulating tyrosinase activity, intracellular signaling pathways such as ex... |
41596276 | Literature Review on Adsorption Efficiency of Paracetamol on Different Adsorbent Materials. | Paracetamol (acetaminophen) is one of the most widely used analgesics and antipyretics. Due to its widespread use, it is also one of the chief contaminants in surface water and wastewater, raising a significant environmental concern. Traditional wastewater treatment systems are ineffective at removing pharmaceutical re... |
41594651 | The Enigmatic Conserved Q134-F135-N137 Triad in SARS-CoV-2 Spike Protein: A Conformational Transducer? | Lipid raft-associated gangliosides facilitate the early stages of SARS-CoV-2 entry by triggering the exposure of the receptor-binding domain (RBD) within the trimeric spike protein, which is initially sequestered. A broad range of in silico, cryoelectron microscopy and physicochemical approaches indicate that the RBD b... |
41594104 | Natural and Synthetic Peptides as Alternatives to Antibiotics in Intestinal Infections-A Review. | <h4>Background/objectives</h4>Antimicrobial peptides (AMPs), evolutionarily conserved components of innate immunity characterized by their broad-spectrum efficacy and minimal resistance development, are increasingly recognized as promising therapeutic candidates. This review aims to integrate current knowledge concerni... |
41590725 | Optimized Conditions for Extracting Native Type-I Collagen from Discarded Fish Skin Using Hydrochloric Acid to Overcome the Drawbacks of Acetic Acid. | Fish skin, a by-product of commercial fish processing, represents a viable source of type I collagen. Acetic acid has been widely used for the extraction of collagen from fish skin because it can preserve the native structure. However, it requires an extraction time of more than 72 h and complex and time-consuming dial... |
41590084 | Supramolecular Organogels Based on Cinnarizine as a Potential Gastroretentive System: In Vitro and In Silico Simulations. | (1) Background: Gastroretentive systems are an interesting option for enhancing the bioavailability of weak bases and poorly soluble drugs. The aim of this study was to formulate supramolecular organogels based on cinnarizine (CIN) as a potential gastroretentive system. (2) Methods: The organogels were prepared with di... |
41586246 | Impact of selenium and selenoproteins on idiopathic male infertility: a comprehensive review. | This comprehensive review systematizes the recent literature on the role of selenium (Se) and selenoproteins in male fertility and the mechanisms involved, by integrating data from animal, human, and <i>in vitro</i> studies. Additionally, it gives an overview of human studies published on the Se levels in seminal plasm... |
41586245 | Targeting aging hallmarks in brain health within the framework of preventive medicine: mechanistic insights into naringenin's role in longevity, synaptic function, and cellular homeostasis. | Aging is the primary driver of neurodegenerative vulnerability and functional decline in the brain. This narrative review synthesizes preclinical <i>in vitro</i> and <i>in vivo</i> evidence on naringenin, a citrus-derived flavonoid with pleiotropic effects on aging-related pathways. Naringenin modulates oxidative stres... |
41585562 | Adipic acid: A green and sustainable crosslinker for innovative food packaging applications. | Biopolymer-based food packaging films are a promising eco-friendly alternative to conventional petroleum-based plastics. Adipic acid (AdA) has gained attention as a green and effective crosslinker for improving the performance and characteristics of biopolymer films. AdA (a dicarboxylic acid) is abundantly found in sou... |
41585444 | Mechanochemical regulation of organoid morphogenesis: Integrated signaling circuits in engineered microenvironments. | Organoid morphogenesis is orchestrated by complex mechanical interactions between cells and their microenvironment. Recent evidence highlights the critical role of mechanical stimuli-including fluid shear stress, axial tensile and compressive forces, extracellular matrix (ECM) stiffness, and viscoelasticity-in integrat... |
41585269 | Application and development of stimulus-responsive hydrogel biomaterials for diabetic wound healing: a literature review. | Diabetic wounds (DWs) are a severe complication of diabetes, defined as the presence of ulcers or deep tissue damage below the ankle in diabetic patients. DWs entail enormous psychological and economic burdens on diabetic patients. The microenvironment of diabetic wound healing is highly complex, characterized by hyper... |
41583445 | Covalent organic frameworks for cancer immunotherapy: mechanisms, applications, and prospects. | Covalent organic frameworks (COFs) have emerged as promising candidates in cancer immunotherapy, owing to their tunable pore structures, versatile functionality, and favorable biocompatibility. This review systematically highlights recent advances in COF-based materials that enhance immunotherapeutic efficacy through m... |
41585867 | Natural products targeting the immune-metabolic regulatory network in pulmonary hypertension: mechanisms, classification, and therapeutic prospects. | Pulmonary hypertension (PH) is a clinical syndrome characterized by progressive elevation of pulmonary vascular resistance, whose pathological process is closely related to the crosstalk between immune dysregulation and metabolic remodeling, forming a complex immune-metabolic regulatory network. The abnormal activation... |
41585717 | Transforming Cellulose for Sustainability: Comprehensive Insights into Modification Approaches and Their Applications. | Cellulose, the most abundant natural biopolymer, has attracted significant attention due to its renewability, biodegradability, low toxicity, and specific tensile strength, enabling diverse applications across multiple sectors. Cellulose-based modified products have diverse applications in numerous fields, including pu... |
41585085 | Lactylation in post-stroke fatigue: linking metabolic dysregulation to neuroinflammation. | Lactylation, a recently identified post-translational modification derived from lactate, has emerged as a key immunometabolic regulator in neurological disorders. In the context of ischemic stroke, abnormal lactate accumulation not only reflects energy metabolism dysfunction but also drives protein lactylation, which d... |
41583059 | HPMA polymers as functional excipients in dermal nanoformulations of imiquimod. | A key challenge in topical drug delivery is the inherently low bioavailability of many active compounds within skin tissue. Here, we present the first comprehensive study investigating the impact of biocompatible hydrophilic polymers based on <i>N</i>-(2-hydroxypropyl)methacrylamide (p(HPMA)) on skin barrier properties... |
41581454 | Supramolecular microgels for Pickering emulsion stabilization in the limited coalescence regime: The key role of microgel structure. | Oil-in-water Pickering emulsions can be stabilized by poly-N-Isopropylacrylamide microgels that adsorb, spread and entangle at the droplets surface. Several studies have tuned the microgels size and deformability to understand the relation between microgel structural parameters, their packing and conformation at the dr... |
41567554 | Molecular mechanism of synergistic tyrosinase inhibition by blueberry and black chokeberry anthocyanidins: Optimal synergistic formulation for multi-berry beverage development. | Tyrosinase is the rate-limiting enzyme in melanogenesis and food browning, making its inhibitors crucial for health and food preservation. However, the specific mechanisms by which multi-berry formulations synergistically inhibit tyrosinase remain uncharacterized, particularly within the context of overcoming bioactivi... |
41561465 | Which halogen to choose? Comparing the effects of chlorine and fluorine as bioisosteric substituents in drug design. | The effects of fluorine and chlorine on pharmaceutical systems are compared using a molecular matched pair analysis. Effects on binding constants, physicochemical properties such as lipophilicity and solubility, as well as on metabolic properties will show the differences and similarities between the elements in a medi... |
41561456 | Sulfone-functionalized stereoisomeric [3]radialene displays guest induced modulation of porous frameworks and critical crystallization-induced near-infrared emission. | Luminescence-responsive porous organic materials have garnered significant interest due to their chemical versatility, adaptability and potential applications in smart sensors and optoelectronic devices. In this study, we introduce a novel class of sulfone-functionalized stereoisomeric [3]radialenes TTRO with quasi-<i>... |
41541574 | Hidden in plain sight: commonly used copper N-heterocyclic carbene catalysts gain stabilization from anagostic Cu⋯H-C interactions. | The ubiquity in organic chemistry of copper catalysts supported by N-heterocyclic carbene (NHC) ligands is often attributed to the ability of sterically bulky and electronically donating NHCs to stabilize low-coordinate intermediates. Here, we show using meta-analysis of 893 solid-state Cu-NHC structures that nearly al... |
41539194 | Cucurbit[8]uril-mediated fluorescent indicator displacement: a novel "turn-on" fluorescent probe for gentamicin detection in water and food samples. | Gentamicin (GEN), an aminoglycoside antibiotic, is widely used in treating infections within the livestock industry but readily causes food residues and environmental pollution. This study developed a novel water-soluble supramolecular fluorescent probe DBTPy<sup>2+</sup>@Q[8], through host-guest interactions between t... |
41529497 | Protective role of Zinc glycine in LPS-induced acute kidney injury in geese: Inhibition of oxidative stress and ferroptosis through Nrf2/GPX4 signaling. | Acute kidney injury (AKI) induced by lipopolysaccharide (LPS) is a critical pathological condition associated with inflammation, oxidative stress, and ferroptosis. Zinc glycine (Zn_Gly), a novel organic zinc complex, has demonstrated anti-inflammatory, antioxidant, and anticancer properties. To investigate the protecti... |
41527555 | Advancements in Polymer-Based Nanocarriers for Controlled Release of Nitric Oxide: Clinical Applications and Future Prospects. | The clinical management of bone defects presents a significant challenge in regenerative medicine due to the limited self-repair capacity of bone tissue and inadequate vascularization. Nitric oxide, a gaseous signaling molecule, has garnered attention as a potent modulator of bone remodeling, exhibiting pro-osteogenic,... |
41523743 | Spectrochemical, medicinal, and toxicological studies of moxifloxacin and its novel analogs: a quantum chemistry and drug discovery approach. | Moxifloxacin (MOX) is regarded as a fourth-generation fluoroquinolone, demonstrating effectiveness against multidrug-resistant tuberculosis (TB) by inhibiting bacterial DNA gyrase. The therapeutic effectiveness of MOX is negatively influenced by side effects that are dependent on dosage, including heart rate-corrected ... |
41523322 | Elastophagocytosis in borderline tuberculoid leprosy: A rare case with diagnostic challenge and histopathological enigma: A case report. | Leprosy, or Hansen's disease, is a chronic granulomatous infection caused by <i>Mycobacterium leprae</i>, with a broad spectrum of clinical and histopathological manifestations. Histological examination plays a pivotal role in accurately diagnosing its various subtypes. Elastophagocytosis (phagocytosis of elastic fiber... |
41522859 | The Polytope Formalism: application to molecular constitution and the prospect of a complete description of Chemical Space. | The principles of the Polytope Formalism - first developed for stereoisomerism - are here extended to molecular constitution (including constitutional isomerism), highlighting a deep connection between these two aspects of structure and opening the way toward a unified description of all isomerism. A key feature of thi... |
41522425 | Stabilizing Cu-Based Photocathodes: From Interfacial Engineering to Advanced Architectures. | Copper-based oxides, including Cu<sub>2</sub>O, CuO, CuBi<sub>2</sub>O<sub>4</sub>, CuFeO<sub>2</sub> and CuFe<sub>2</sub>O<sub>4</sub> have emerged as promising photocathode materials for solar-driven photoelectrochemical (PEC) reduction reactions such as hydrogen evolution (HER), carbon dioxide reduction (CO<sub>2</s... |
41522242 | A systematic comparison of density functional methods for determining spin-state energy gaps and spin transition temperature of spin crossover complexes. | In this paper, the spin-crossover (SCO) behavior of 26 transition metal complexes has been investigated by Density Functional Theory (DFT) using nine density functionals such as TPSS, BLYP, TPSSh, B3LYP, B3LYP*, OPBE, O3LYP, B3P86, and X3LYP, providing a comprehensive analysis of their effect towards computing spin-sta... |
41520562 | Zinc overload disrupts SoxR [2Fe-2S] clusters to drive redox-metallic crosstalk via SoxS-ZnuACB in Escherichia coli. | Here, we demonstrate that excess zinc disrupts bacterial redox sensing by specifically disassembling the [2Fe-2S] cluster of SoxR - a master oxidative stress sensor in Escherichia coli. This impairment couples zinc overload to dysregulated oxidative defense, revealing a previously unrecognized metal-redox crosstalk mec... |
41519336 | TiO<sub>2</sub>-chitosan-cyclodextrin polymers based on subject-object recognition for adsorption-assisted photocatalytic degradation of Congo red. | Water pollution caused by anionic dyes, particularly exemplified by Congo Red (CR), poses a serious threat to ecosystems. To address this, a TiO<sub>2</sub>-chitosan-cyclodextrin polymer (CS-β-CDP/TiO<sub>2</sub>) was prepared via a host-guest recognition strategy. Its unique structure not only prevented the aggregatio... |
41512796 | Targeted alleviation of local inflammation by a hydroxypropyl-cyclodextrin-encapsulated prodrug of methyl salicylate and menthol though Nrf2/NF-κB pathway. | Antibiotics remain the conventional mainstay for acute local inflammation, such as pharyngitis, but concerns over bacterial resistance, superinfections, and hepatorenal toxicity have driven research toward natural alternatives. Methyl salicylate (SAM) and L-menthol (MENT), derived from medicinal plants, exhibit anti-in... |
41508405 | Bioinspired Spatiotemporal-Responsive Nanoparticles Synergistically Regulate Mitochondrial Repair and Inhibit Fibrosis in Acute Myocardial Infarction Treatment. | Cardiovascular diseases, particularly acute myocardial infarction (AMI), have posed a significant global health burden due to the high morbidity and mortality rates. Current treatment methods are compromised by a narrow therapeutic window, risk of ischemia-reperfusion injury, rapid systemic drug clearance, and inadequa... |
41508343 | Spacer-Length-Dependent Nuclearity and Cuprophilic Modulation in Copper(I) Complexes with Multidentate β-Thioketiminate Ligands. | This study explores the impact of alkyl spacer length in multidentate β-thioketiminate ligands (H<sub>2</sub><sup>2</sup><b>L</b>-H<sub>2</sub><sup>4</sup><b>L</b>, H<sub>2</sub><sup>6</sup><b>L</b>, and H<sub>2</sub><sup>8</sup><b>L</b>) on the nuclearity and structural properties of copper(I) complexes. Ligands, synt... |
41508297 | Heterojunction-Engineered MgO@rGO/PVDF-HFP Flexible Films for Highly Efficient Piezocatalytic Degradation and Antibacterial Applications. | In this work, PVDF-HFP-based piezoelectric composite films incorporating MgO and rGO nanofillers were fabricated via a facile phase-separation method. The influences of filler composition and loading amount on their piezocatalytic and antibacterial performances were systematically investigated. MgO@rGO/PVDF-HFP film (4... |
41508109 | Bilateral rhabdomyolysis after radical hysterectomy in the prolonged lithotomy position: a case report. | <h4>Background</h4>Rhabdomyolysis is a rare but severe complication of surgery. It usually presents as localized pain, swelling, numbness, and muscle weakness in the damaged counterpart and may be accompanied by myoglobinuria and varying degrees of elevated creatinine phosphokinase.<h4>Case presentation</h4>In this cas... |
41508098 | Interpretable machine-learning prediction of PSEN1 missense variant pathogenicity based on multi-omics enrichment in six core Alzheimer's disease genes. | <h4>Background and objective</h4>The clinical interpretation of Alzheimer's disease (AD) is frequently complicated by the prevalence of missense variants designated as being of uncertain significance within associated genes. Conventional computational prediction tools often overlook disease-specific pathophysiological ... |
41508018 | Microglia-derived iron-overloaded exosomes induce neuronal ferroptosis and aggravate neurological impairment after subarachnoid hemorrhage. | Subarachnoid hemorrhage (SAH) is a devastating stroke subtype often leading to poor neurological outcomes. Iron homeostasis imbalance is a key contributor to cognitive dysfunction in neurological diseases. Extracellular vesicles, including exosomes (EXs), are crucial mediators of intercellular communication. This study... |
41507932 | Nano-PROTACs for precision medicine: engineering strategies for enhanced targeting and potency. | Proteolysis-targeting chimeras (PROTACs) represent a transformative therapeutic modality that leverages the endogenous ubiquitin-proteasome system (UPS) to achieve targeted protein degradation. These heterobifunctional molecules facilitate the recruitment of E3 ubiquitin ligases to a protein of interest (POI), promotin... |
41507804 | Genome-wide analysis of WRKY gene family in Cucurbita moschata and involvement of CmWRKY22/63/84 in powdery mildew resistance. | <h4>Background</h4>Powdery mildew (PM), mainly caused by Podosphaera xanthii, is a severe biotrophic pathogen disease of global Cucurbitaceae vegetables. However, Cucurbita moschata (pumpkin) strongly resists PM and shows wide adaptability. WRKY transcription factors participate in plant response to pathogen stresses, ... |
41507424 | Genome anchoring, retention, and release by neck proteins of Staphylococcus phage 812. | The virion of Staphylococcus phage 812 is formed by a capsid and a contractile tail joined together by neck proteins. The neck proteins are crucial for virion assembly, DNA packaging, and the regulation of genome release, but their functions are not completely understood. Here, we show that the neck of phage 812 consis... |
41507418 | Pharmacological tools to modulate ordered membrane domains and order-dependent protein function. | Ordered membrane nanodomains colloquially known as "lipid rafts" have many proposed cellular functions. However, pharmacological tools to modulate protein affinity for rafts and to manipulate raft formation are currently lacking. We screened 24,000 small molecules for compounds that impact the raft affinity of a known ... |
41507410 | Simple and efficient co-synthesis of gold nanoparticles and nanoclusters for HPV-16 detection. | The detection of HPV-16 is essential for cervical cancer molecular diagnostics at the point of care and in the early stages. Current diagnostic methods, however, find it difficult to balance cost-effectiveness with good analytical performance. We have created a unique nanobiosensor that uses colorimetric and fluorometr... |
41507383 | Advanced breath analysis through hierarchical deep convolutional neural network for multi-cancer screening. | Breath analysis offers a promising noninvasive strategy for early cancer detection by capturing disease-specific volatile organic compound (VOC) signatures in exhaled breath. In this study, we developed a hierarchical deep convolutional neural network (HD-CNN)-based platform for dual-cancer classification using a multi... |
41507346 | Role of dislocations in self-assembled 2D layered raspberry surface to 3D flower-like microstructural evolution in hybrid halide perovskite. | Molecular self-assembly is a unique process in nature leading to interesting growth of crystals and layered structures. However, understanding the nucleation pathways leading to the formation and evolution of self-assembled molecular structures is often more complex to decipher from experimental and theoretical investi... |
41507294 | Coarse-grained molecular dynamics simulation of gallic acid delivery using span60-based niosomes. | We have previously parameterized a coarse-grained representation of span60 for use with the Martini 3 force field and employed it to simulate niosome bilayers. In this study, we extend this simulation framework to investigate the formation and dynamics of three-dimensional niosomes under varying cholesterol concentrati... |
41507237 | Synthesis, spectroscopy, density functional theory study and biological activity of [Cu(phen)(L-arg)Cl]Cl·2.5H<sub>2</sub>O. | Copper complexes are known for a range of biological properties that include anticancer, antimicrobial, and superoxide dismutase-like activities. In this work, we describe the synthesis of [Cu(phen)(L-arg)Cl]Cl·2.5H<sub>2</sub>O crystal, formed by the complexation of the metallic ion copper(II) with organic ligands - 1... |
41507206 | Increasing quality stability of jasmine tea beverage by encapsulation from protein-polysaccharide nanocomplexes. | As widely consumed beverage, the stability is crucial to the quality and shelf life of tea beverage. In this study, whey protein isolate (WPI)-beta-cyclodextrin (β-CD) was added to investigate its effect on the stability of jasmine tea beverage by pH, thermal and storage stability. The results showed tea beverages unde... |
41507164 | Butyrophilin 2A2 promotes T cell immunoregulation via CD45 phosphatase activation and protects against murine autoimmune glomerulonephritis and pregnancy loss. | B7 costimulatory family member Butyrophilin 2A2 (BTN2A2) is predominantly expressed by antigen presenting cells and regulates T cell immunity, but molecular mechanisms are unclear. Using immunoblots analyzing TCR-initiated signaling intermediaries, co-immunoprecipitation studies, confocal microscopy, structural modelin... |
41507033 | Metal-Organic Framework@Gold Nanoparticles Enables Point-of-Care Diagnostics To Have Comparable Analytical Performance to Chemiluminescent Immunoassays. | Lateral flow immunoassay (LFIA) is a vital point-of-care testing (POCT) technique that is widely used for on-site detection and in vitro diagnosis. Many diseases, particularly cardiovascular diseases (CVDs), require the quantitative detection of multiple biomarkers across a broad dynamic range. Recurrent viral infectio... |
41506958 | Toward development of a dynamic supramolecular peptide therapy for acute ischemic stroke. | Acute ischemic stroke (AIS) treatment relies on early restoration of blood flow; however, ischemia/reperfusion (I/R) may lead to secondary brain injury. Supramolecular peptide assemblies in which many molecules move collectively by design can activate key cellular pathways by displaying bioactive molecules on their sur... |
41506862 | Topological Supramolecular Network-Enabled PEDOT:PSS Hydrogel Sensor for High-Sensitivity Strain Monitoring and EMG/ECG Bioelectronic Sensing. | Stretchable conductive hydrogels have emerged as ideal interfaces for seamless and biocompatible integration with human skin, showing significant potential in medical electronic applications. However, achieving a balance between high mechanical robustness and excellent electrical conductivity remains challenging, parti... |
41505733 | Extension of Solvent-Assisted Linker Exchange to Supported Metal-Organic Framework Thin Films. | Solvent-assisted linker exchange (SALE) is a common postsynthetic approach used to accommodate metal-organic frameworks (MOFs) for targeted applications. As this technique is relatively untested in immobilized MOF structures, we repeated the generalized SALE approach with ZIF-8 deposited directly onto solid substrates ... |
41505603 | Assembling Lipid Membrane Scaffolds on Microgel-Based Artificial Cells through Vesicle Fusion onto the Hydrogel Network. | Artificial cells assembled from materials such as hydrogels have emerged as platforms to replicate and understand biological functionalities, processes, and behaviors. However, hydrogels lack a lipid membrane, a vital property of cellular systems. Here we develop a process for the assembly of a fluid and stable lipid m... |
41505524 | SARS-CoV-2 peptide fragments selectively dysregulate specific immune cell populations via Gaussian curvature targeting. | Immune cell populations are dysregulated in COVID-19 for currently unknown reasons: Plasmacytoid dendritic cell (pDC) populations are reduced, thus hampering antiviral responses. CD8<sup>+</sup> T cell populations are reduced, the level of which has emerged as an index of disease severity. Recent work has shown that th... |
41505492 | Peroxo-Thorium(IV)-Containing Heteropolytungstates and Their Oxo-Analogues: Synthesis, Structure and Solution Studies. | We report the synthesis of peroxo-thorium(IV)-containing silico- and germanotungstates, [Th<sub>3</sub>(μ<sub>3</sub>-O<sub>2</sub>)(OH)<sub>2</sub>(H<sub>2</sub>O)<sub>3</sub>(<i>A-</i>α-XW<sub>9</sub>O<sub>34</sub>)<sub>2</sub>]<sup>12-</sup> (X = Si, <b>Th</b><sub><b>3</b></sub><b>O</b><sub><b>2</b></sub><b>Si</b>; ... |
41505468 | CRISPR/Cas12a-RCA enables ultrasensitive detection of circulating free DNA for noninvasive diagnosis of echinococcosis. | <h4>Objective</h4>To develop a novel non-invasive CRISPR/Cas12a-RCA assay for the primary screening of human echinococcosis via detection of circulating Echinococcus cell-free DNA (cfDNA) in peripheral blood.<h4>Methods</h4>Plasma cfDNA from 20 AE patients was analyzed via high-throughput sequencing to identify conserv... |
41505409 | Zn-Quer Nanozymes Reprogram the Malignant Phenotypic Transformation of Gastric Cancer Cells via Cascade Reactive Oxygen Species Coordination. | Gastric cancer (GC) remains one of the leading causes of cancer-related mortality worldwide, presenting significant therapeutic challenges due to its late-stage diagnosis and high metastatic potential. Imbalance in reactive oxygen species (ROS) homeostasis is crucial for the onset, development, and malignant transforma... |
41505077 | The MOF-Microbiome Axis: a New Paradigm for Precision Nanomedicine. | The gut microbiome is crucial for human health, and its imbalance, known as dysbiosis, is associated with diseases such as inflammatory bowel disease, metabolic disorders, and neurological disorders. Traditional treatments, such as probiotics and fecal microbiota transplants, often lack precision, making the emerging f... |
41504814 | Nanoparticles in HIV treatment for improved drug delivery, clinical translation, and future direction. | HIV remains a major global health challenge with antiretroviral therapy (ART) effectively suppressing viral replication. However traditional ART does not eliminate viral reservoirs and is limited by systemic toxicity, long-term adherence burdens, and incomplete tissue penetration. These limitations highlight an importa... |
41504719 | Photo/Biohybrid Catalytic System for Application in Semiartificial Photosynthesis of CO<sub>2</sub> to Chemicals. | Carbon dioxide capture, utilization, and storage (CCUS) technology is expected to be one of the key technologies for achieving a carbon-neutral society in the near future. One promising area of CCUS technology is research into artificial photosynthesis mimicking natural photosynthesis. Since natural photosynthesis uses... |
41504616 | Sulfondiimidoyl-Containing Hypervalent Iodine(III) Compounds: Synthesis and Reactivity. | <i>N</i>-Monosubstituted sulfondiimines react with methoxy(tosyloxy)iodobenzene (MTIB) to give unprecedented <i>N</i>-connected hypervalent iodine(III) compounds in high to excellent yields. The pure products are obtained by simple filtration of the reaction suspension after reaction times of 3-30 min. Broad variations... |
41504549 | Water-Processable Covalent-and-Supramolecular Polymeric Binders for Silicon/Carbon Anodes with High Interfacial Stability in Lithium-Ion Batteries. | Silicon/carbon (Si/C) composite anodes are among the most promising candidates for high-energy-density lithium-ion batteries but suffer from severe volume fluctuation and interfacial degradation during cycling. Herein, we report a water-processable covalent-and-supramolecular polymeric binders (CSPBs) that synergistica... |
41504491 | Spatio-Temporal Proteomic Landscape Reveals Early Warning Signals of Esophageal Squamous Cell Carcinoma Progression. | Esophageal squamous cell carcinoma (ESCC) remains a lethal malignancy lacking reliable biomarkers for precancerous lesion monitoring and intervention. In this study, formalin-fixed, paraffin-embedded archived tissue biopsies from 134 individuals across two cohorts are collected, spanning five stages of ESCC progression... |
41504482 | Organic Afterglow Vesicles. | Organic afterglow materials hold great promise for applications in bioimaging, sensing, and information encryption, yet the construction of advanced nanostructures like vesicles with long-lived luminescence remains a formidable challenge. We pioneer the construction of organic afterglow vesicles via polymerization-indu... |
41504468 | Binary Biobased Supramolecular Colloidal Suspensions: A Model for Sustainable Antibacterial Coatings and Soft Carrier Systems. | Applying antibacterial coatings onto food processing surfaces is essential for mitigating bacterial contamination, ensuring food safety, and maintaining hygienic standards in food production environments. This study explores environmentally friendly and food-safe antibacterial colloidal suspensions consisting of aggreg... |
41504445 | Salvianolic acid A exerts antiviral effects by targeting the S protein, a virulence factor of porcine epidemic diarrhea virus. | Porcine epidemic diarrhea virus (PEDV), a member of the Coronaviridae family, infects the small intestinal epithelial cells of pigs, causing porcine epidemic diarrhea (PED), which is particularly severe in young piglets. Owing to its strong immunogenicity, the S1 subunit of the PEDV spike (S) protein mediates viral inv... |
41504442 | Coronavirus genome packaging and nucleocapsid assembly. | Coronaviruses are a family of positive-strand RNA viruses that exhibit highly selective packaging of their genomic RNA (gRNA) into assembled virions, despite the presence of a large excess of subgenomic viral RNA species and host RNA in infected cells. While this high selectivity is critical to evading host innate immu... |
41504417 | Scalable Multiparametric Characterization of Aptamer-Target Interactions. | Structure-switching aptamers transduce target-induced conformational changes into detectable signals, enabling the specific detection of small molecules with limited surface area and charge. Understanding these structural transitions is critical for the rational design of aptamers in downstream biosensing. However, cur... |
41504351 | Pressure-Induced Self-Assembly in 3-Phenylpropanal: Distinct Clustering via π-Stacking and Distorted Hydrogen Bonds. | This paper investigates the effect of high pressure on the dynamics, intermolecular interactions, and association mechanisms of 3-phenylpropanal (3P1 Pal). Dielectric investigations have revealed an unusual behavior of the Debye process at high compression, indicating a distinct clustering mechanism. Complementary Four... |
41504301 | A Universal Metal-Flavonoid Coating Strategy: Engineering Biomaterials for Diabetic Bone Regeneration. | Under metabolic disorders such as diabetes, the regenerative capacity of bone tissue is compromised, characterized by hyperglycemia-induced oxidative stress, impaired osteogenesis, and dysregulated angiogenesis. These complications undermine the efficacy of conventional bone repair materials, limiting their capacity to... |
41504259 | CD20<sup>+</sup>FCRL4<sup>+</sup> B Cells Activate CD8<sup>+</sup> T Cells via MHC-I Restriction in Nasopharyngeal Carcinoma Anti-Tumor Immunity. | Nasopharyngeal carcinoma (NPC) is a malignant tumor characterized by extensive immune cell infiltration. However, the function and significance of B cells in NPC have been overlooked. Exploring B cells and their interactions with other immune cells will provide deeper insights into the immune microenvironment of NPC an... |
41504180 | Nanomaterial-Based Inkjet Printing for Electrochemical Sensing. | Inkjet printing (IJP) has emerged as a transformative technology for printed and flexible electronics, redefining electrode engineering for (bio)chemical sensing. It enables maskless, picoliter-scale, additive deposition with high spatial precision, uniformity, and material efficiency. We provide a comprehensive overvi... |
41504153 | Directing Intermediates in Photocatalytic H<sub>2</sub>O<sub>2</sub> Production to Boost Uranium Extraction from Seawater. | Extracting uranium from seawater is crucial for ensuring the supply of uranium resources and the sustainable development of nuclear energy. Photocatalysis-assisted extraction strategy, where photo-catalytically generated H<sub>2</sub>O<sub>2</sub> reacts with uranyl ions to form metastudtite, could effectively enhance ... |
41504149 | A Blood-Brain Barrier-Penetrant Ag(III) Corrole Compound Rescues Alzheimer's Disease Pathology by Targeting Aβ42-Induced Oxidative Stress. | Alzheimer's disease (AD) lacks disease-modifying therapies, partly due to the blood-brain barrier (BBB) limiting drug delivery and the multifaceted toxicity of amyloid-β (Aβ42) oligomers. Here, this work reports the design, synthesis, and comprehensive characterization of a rationally designed silver(III) corrole compl... |
41504145 | Ambient Stabilization of Metastable Face-Centered Cubic Lanthanide Trihydrides. | Achieving ambient stability of hydrogen-rich materials synthesized under extreme conditions remains a major barrier to unlocking their functional potential. Here, we report a general high-pressure-high-temperature (HPHT) strategy using large volume press (LVP) to stabilize metastable face-centered cubic (fcc) phases of... |
41504068 | Mechanism-Dependent Oxygen Tolerance of Mn(bpy)CO<sub>3</sub>Br in Electrochemical CO<sub>2</sub> Reduction. | CO<sub>2</sub> capture and utilization require the development of highly selective catalysts that convert low-concentration CO<sub>2</sub> into valuable chemicals. Direct air capture (DAC) CO<sub>2</sub> contains up to 10% of oxygen as an impurity, which is a sincere competitor to the electrochemical CO<sub>2</sub> red... |
41504033 | From Transient to Stable: Incorporating Electrophiles in Genetically-Encoded and DNA-Encoded Libraries of Peptide-Derived Macrocycles. | Peptide-derived macrocycles are an emerging class of therapeutics capable of modulating protein-protein interactions that remain inaccessible to small molecules. Genetically encoded library (GEL) platforms such as phage and mRNA display have accelerated macrocyclic ligand discovery by linking peptide sequence to genoty... |
41504025 | Rapid Self-Healing and Self-Adhesive Supramolecular-Polymer Double-Network Eutectogels for Wearable Flexible Sensors in Human-Machine Interaction. | The development of gel-based soft materials has greatly promoted the advancement of flexible electronic devices. However, fabricating gels with excellent overall properties for dynamic, complex environments remains challenging. Herein, we report a supramolecular-polymer double-network (SP-DN) eutectogel constructed in ... |
41504009 | MOF in Polymer Electrolytes Raising Ion Transport for Breakthrough Lithium Metal Batteries. | SPEs have gained significant attention in lithium metal batteries for enhanced safety. However, low ionic conductivity and dendrite formation limit the performance. To address these limitations, a novel composite-type SPE was developed by incorporating phytic acid(PA)-functionalized ZIF-67 (ZIFP) into （N-Methyl-2-Pyrro... |
41503974 | Sulfur-Anion-Modulated Electron Configuration of Manganese Selenide for High Performance Sodium Ion Storage. | Manganese selenide (MnSe), as a typical electrode material, has garnered significant attention due to its high theoretical specific capacity and cost-effectiveness. However, persistent challenges, including sluggish reaction kinetics and inadequate cycling stability, remain to be addressed. Anion-doping-induced defect ... |
41503970 | Oxygen-Rich Zn-Vitamin C Framework Enabling Specific Host-Guest Recognition for Selective Hydrocarbon Separation and Dual-Mode Fruit Preservation. | Tailored host-guest interactions are essential for developing multifunctional adsorbents, yet integrating distinct adsorption roles into a single robust framework remains rare. Herein, we represent a green, biocompatible Zn-based metal-organic framework (ZnVc) constructed from edible-grade vitamin C ligands. The result... |
41503921 | Heteroatoms-doped Transition Metal Dichalcogenides Confined in Mesoporous Nitrogen-doped Carbon Microspheres With Radial Pores for NO<sub>2</sub> Sensing. | Transition metal dichalcogenides (TMDs) have attracted significant attention in electronic devices, energy storage, and catalysis owing to their distinctive electronic properties and abundant active sites. Introducing mesoporosity into TMDs is extremely favorable to enhance the host-guest interactions and improve their... |
41503892 | Step-Ladder Bioprinting to Align Collagen Fibers for Anisotropic Tissue Fabrication. | Aligned collagen microstructure is essential for the mechanical and biological function of anisotropic tissues. However, conventional engineering methods often fail to achieve consistent and tunable fiber alignment within complex geometries. In this study, we developed a step-ladder printing (SLP) approach by incorpora... |
41503886 | Terrylene: Synthesis, Modifications, and Multifaceted Applications. | As a higher homologue of rylene with six fused benzene rings, terrylene exhibits distinct optoelectronic properties compared to its lower analogues, naphthalene, and perylene. In 1948, E. Clar reported the synthesis of terrylene for the first time, marking the beginning of higher rylene chemistry. Numerous synthetic ro... |
41502406 | Dual anti-pseudomonal and resistance-modulatory actions of <i>Sida acuta</i> (Malvaceae) via BamB-OprM targeting: insights from integrated metabolomics, computational, and <i>in vitro</i> analyses. | <h4>Context</h4>The growing multidrug resistance (MDR) of <i>Pseudomonas aeruginosa</i> presents a pressing global health challenge and demands novel solutions. Medicinal plants offer a largely untapped reservoir of structurally diverse compounds with promising antibacterial and adjuvant potential.<h4>Objective</h4>Thi... |
41502393 | Orthogonal Investigation at Single-Particle and Ensemble Levels Uncovers Lipoprotein-Extracellular Vesicle Binding. | Mesoscale interactions critically shape the biological identity of extracellular nanoparticles, including extracellular vesicles. These interactions encompass biomolecular coronas, transient aggregation, and fusion events. Among them, the interaction between extracellular vesicles and lipoproteins has recently garnered... |
41502367 | Redox-Switchable Halogen Bonding in Haloanthracene Mediators Enables Efficient Electrocatalytic C-N Coupling. | We report the development of redox mediators based on 9-halo-10-arylanthracenes that engage in halogen bonding only upon one-electron oxidation. This redox-switchable interaction enables an effective substrate preorganization and promotes intramolecular C-N bond formation via electrocatalysis. Systematic evaluation of ... |
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