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41614892 | Marine Bromophenol Derivatives as a Novel Class of Potent Small-Molecule STING Agonists. | Activation of the stimulator of interferon genes (STING) pathway has emerged as a promising strategy for cancer immunotherapy. However, the initial cyclic dinucleotide (CDN) analogs developed as STING agonists have shown limited efficacy in clinical trials, prompting interest in non-CDN small-molecule alternatives. In ... |
41600981 | The Yellow Fever Vaccine Journey: Milestones and Future Directions. | Yellow fever, a mosquito-borne viral hemorrhagic disease, remains a significant public health concern in endemic regions of Africa and South America. The development of the yellow fever vaccine marked a milestone in virology and immunization. In the 1930s, Max Theiler created the 17D live-attenuated vaccine, a breakthr... |
41599179 | Self-Stabilizing Covalent Ligand Targets Bacterial Phosphatidylethanolamine and Enhances Antibiotic Efficacy. | <b>Background/Objectives</b>: Discriminating bacterial from mammalian membranes remains a central challenge in antibiotic design. Bacterial membranes are enriched in phosphatidylethanolamine (PE), a lipid normally absent from the outer leaflet of mammalian cells, providing a signature for selective molecular engagement... |
41595640 | Targeting Yeast Pathogens with Lectins: A Narrative Review from Mechanistic Insights to the Need for Addressing Translational Challenges. | Diseases associated with yeast pathogens have become an increasingly serious global health issue. The range of virulence factors and the development of mechanisms of resistance have posed a significant challenge in the fight against these types of infections. Lectins, proteins capable of reversibly binding to carbohydr... |
41594095 | Fatty Acids as Prebiotics and Their Role in Antibiofilm Activity. | Microbial biofilms pose significant medical and industrial challenges due to their resistance to conventional antimicrobials, accounting for 40-80% of bacteria in various environments. This resistance primarily results from the extracellular polymeric matrix, a protective network of sugars, proteins, and other molecule... |
41590965 | One Sprinter, Two Olympic Preparations: A Single-Athlete Longitudinal Observational Study of Training-Intensity Distribution and Implications for Future 50 m Events. | <b>Purpose:</b> This single-athlete, longitudinal observational study describes training intensity distribution (TID) across two Olympic preparation cycles (Rio 2016 vs. Tokyo 2021) and explores whether differences in high-intensity exposure coincided with performance outcomes. <b>Methods:</b> An elite male 50 m freest... |
41590588 | Polysulfone Membranes: Here, There and Everywhere. | Polysulfone (PSU) membranes are widely recognized for their thermal stability, mechanical strength, and chemical resistance, making them suitable for diverse separation applications. This review highlights recent advances in PSU membrane development, focusing on fabrication techniques, structural modifications, and eme... |
41590529 | Radiolabeled Vitamins and Nanosystems as Potential Agents in Oncology Theranostics: Developed Approaches and Future Perspectives. | Theranostic approaches employing radioactive materials have emerged as innovative strategies that integrate molecular imaging with targeted therapy using nanosystems, thereby advancing the paradigm of precision medicine in oncology. Each year, substantial research efforts are dedicated to developing molecular probes ca... |
41590080 | Towards Enhanced Battery Thermal Safety: A Lightweight and Mechanically Robust Aerogel with Superior Insulation. | With the continuous increase in energy density of lithium-ion batteries, thermal safety has become a critical constraint on their further development. To address the limitations of mechanical brittleness and high-temperature infrared transparency in SiO<sub>2</sub> aerogels for thermal safety applications in lithium-io... |
41589031 | Nano-Winter Is Coming for Sperm Cryopreservation: Advanced Approaches for Life in Ice: A Review. | Cryopreservation (CP) can negatively impact sperm quality, but recent studies have shown promising results using nanoparticles (NPs) as cryoprotectants. This review examines the potential of various NP types, including metallic, magnetic, polymeric, and lipid-based, in improving post-thaw sperm characteristics across d... |
41585727 | Study on the Binding of Five Plant-Derived Secondary Metabolites to G‑Quadruplexes. | Chemical targeting of noncanonical secondary structures of DNA and RNA has emerged as a promising approach for therapeutic development. The most promising targets seem to be four-stranded structures in the G-rich regions of the genome, known as G-quadruplexes (G4s), which are associated with important regulatory region... |
41585743 | Photopharmacology of Quinoline and Benzimidazole Azobenzene-Based Photoswitchable β‑Hematin Inhibitors. | Recent advances in antimicrobial drug design have incorporated photopharmacology to control drug behavior through light activation, alongside traditional phenotypical strategies including molecular hybridization and metal incorporation. The quinoline and benzimidazole scaffolds are important chemical frameworks identif... |
41562074 | The multifaceted role of post-translational modifications in macrophage polarization: from mechanisms to therapeutic targets. | Macrophage polarization is central to immune homeostasis and disease pathogenesis. It is achieved through complex regulatory networks mediated by post-translational modifications (PTMs). This review synthesizes the roles of phosphorylation, ubiquitination, methylation, acetylation, and lactylation in shaping polarizati... |
41562066 | Decoding the immunoregulatory functions of ALKBH5 in the tumor microenvironment. | N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) modification represents the most prevalent internal RNA modification and plays a pivotal role in regulating RNA metabolism and cellular function. As a major m<sup>6</sup>A demethylase, ALKBH5 not only orchestrates tumor cell proliferation, migration, and metabolic reprogra... |
41562049 | The emerging roles of METTL1-mediated tRNA m<sup>7</sup>G methylation in cancer development and immunotherapy. | RNA modifications, particularly N7-methylguanosine (m<sup>7</sup>G), have emerged as critical epigenetic regulators in cancer biology. METTL1, a conserved S-adenosylmethionine-dependent methyltransferase, catalyzes m<sup>7</sup>G modification primarily on tRNA, often in complex with its cofactor WDR4. This modification... |
41561686 | Wetware network-based AI: a chemical approach to embodied cognition for robotics and artificial intelligence. | <i>Wetware Network-Based Artificial Intelligence</i> (WNAI) introduces a new approach to robotic cognition and artificial intelligence: autonomous cognitive agents built from synthetic chemical networks. Rooted in <i>Wetware Neuromorphic Engineering</i>, WNAI shifts the focus of this emerging field from disembodied com... |
41561633 | The varied functions of the giant muscle scaffold protein obscurin. | Obscurin is a giant protein encoded by the <i>OBSCN</i> gene in human myocytes, known for its roles in sarcomere organization, elasticity, stretch response, and myofibrillogenesis. Alternative splicing of <i>OBSCN</i> generates variants with distinct properties and localizations, including small kinase variants in mamm... |
41561628 | Kv2.1 negatively regulates Reissner fiber development. | <h4>Introduction</h4>The potassium voltage-gated channel Kv2.1 plays a crucial role in the development of the brain's ventricular system. Defects in the development of this system affect the formation of the Reissner fiber, a rope-like structure produced by the flexural and subcommissural organs that secrete Scospondin... |
41561594 | Exploring the impact of growth mindset and grit on college students' athletic performance. | Psychological factors (e.g., mindset and grit) are increasingly recognized as pivotal to endurance performance, yet their joint influence on endurance task in physical education remains under-explored, especially among Chinese university students. This study tested whether growth mindset and grit predict 800-meter run ... |
41561459 | Interplay between diradical character, aromaticity and conductance in oligothiophenes. | The fundamental relationships of the diradical character-aromaticity-conductance triangle are elucidated across a diverse set of oligothiophenes capable of adopting both aromatic and quinoidal structures. The electronic ground-state was determined using open-shell/closed-shell and singlet-triplet adiabatic energy gaps,... |
41561347 | Treatment of diabetic wound based on hypoglycemic and antioxidant. | Diabetic ulcers are among the severe complications of diabetes. The accumulation of hyperglycemia and reactive oxygen species (ROS) in these ulcers significantly delays wound healing. Nanomedicine offers promising advantages for targeted drug delivery and enhanced therapeutic efficacy in treating diabetic ulcers associ... |
41561088 | Antimicrobial peptides: natural templates for next-generation therapeutics against antimicrobial resistance. | Antimicrobial resistance is a growing global health crisis, responsible for nearly five million deaths annually and projected to double by 2050 as conventional antibiotics fail against multidrug-resistant pathogens. AMR is aggravated by antibiotic misuse, weak regulations, inadequate prevention, high treatment costs, a... |
41561084 | Enhancing the structural stability of P29-targeted monoclonal antibodies via β-hydroxybutyrylation modification improves their therapeutic performance in alveolar echinococcosis. | <h4>Background</h4>Alveolar echinococcosis (AE), a severe parasitic infection often likened to "parasitic cancer", still lacks effective treatments. Although our earlier ork on the P29 monoclonal antibody (P29 mAb) against the parasite-derived P29 antigen showed potential, its efficacy remained limited, prompting the n... |
41561080 | Diverse, novel mycoviruses coinfecting the phytopathogenic fungus <i>Corynespora cassiicola</i> from <i>Sesamum indicum</i>. | <h4>Introduction</h4>Corynespora leaf spot caused by <i>Corynespora cassiicola</i> is one of the most serious foliar diseases of sesame. Mycoviruses can infect various groups of fungi and have certain potential biocontrol value. However, the number of mycovirus reported in <i>C. cassiicola</i> is relatively scarce.<h4>... |
41561027 | <i>Pseudomonas aeruginosa</i> LasI/RhlI quorum sensing system controls protease-mediated autoaggregation behavior, cell envelope characteristics and extracellular proteome responses. | Quorum sensing (QS) is an intercellular communication mechanism employed by the opportunistic bacteria <i>Pseudomonas aeruginosa</i> to regulate processes beneficial to the longevity of the community and related to its pathogenicity. The LasI/Rhl circuits of the quorum-sensing (QS) network operate through <i>N</i>-acyl... |
41560920 | Plant-derived vesicles: isolation strategies and therapeutic applications. | Plant-derived vesicles (PDVs) are vesicle-like structures secreted by plant cells, containing components such as membrane proteins、nucleic acids and enzymes. These vesicles play significant roles in plant growth, tissue repair and self-defense. Additionally, PDVs are safe and easy to extract, and they demonstrate promi... |
41560902 | Enhanced water treatment via combined oxidation and adsorption: a synergistic approach. | Organic micropollutants are still a major environmental and public health problem because they accumulate in all water source over the world. Because standard treatment is ineffective at the low concentrations at which these contaminants are present to remove, there is an urgent need to find better tertiary treatments ... |
41560903 | Enhanced microwave-assisted methodology for obtaining cutin monomers from tomato peel. | Tomato pomace is an abundant by-product of the agri-food industry with a peel rich in cutin, a plant polyester that can be depolymerized to monomeric building blocks to develop bio-based materials. Because of cutin's crosslinked, three-dimensional structure, alkaline hydrolysis has typically required long reaction time... |
41560861 | Whole-genome characterization and phylogenetic analysis of pigeon circovirus in racing pigeons from Heilongjiang, China. | Pigeon circovirus (PiCV), a globally distributed pathogen, is associated with immunosuppression and high mortality in racing pigeons. Despite its endemicity in Chinese pigeon populations, molecular epidemiological data on PiCV in Northeast China remain scarce. This study reports the first complete genome sequence of Pi... |
41560835 | Aptamer-liposome targeted nanotherapeutics for cancer therapy: Bibliometric analysis, recent developments and future perspectives. | As one of the leading causes of death worldwide, cancer has driven the advancement of targeted therapy toward greater precision and reduced off-target effects. Liposomes, with their biocompatibility, tunable properties, and clinical success, are among the most promising nanocarriers, yet their tumor-targeting specifici... |
41560836 | Intranasal delivery of Odorranalectin-modified lipid nanoparticles for multi-targeted therapy of Alzheimer's disease. | Oxidative stress, neuroinflammation, and β-amyloid (Aβ) deposition act synergistically to drive Alzheimer's disease (AD) progression. Effective treatment, therefore, requires multi-targeted strategies capable of addressing these interconnected pathological mechanisms. Here, an Odorranalectin (OL)-conjugated lipid nanop... |
41560746 | Effectiveness of drug-loaded poly(ethylene glycol) and poly(lactic-co-glycolic-acid) nanoparticles in the <i>in vitro</i> treatment of breast cancer: a systematic review. | <h4>Background</h4>Breast cancer treatment remains a major challenge to modern medicine and has driven the need for nanotechnology-based strategies to improve drug delivery and overcome chemoresistance. Poly(ethylene glycol) and poly (lactic-co-glycolic acid) (PEG-PLGA) nanoparticles (NPs) are a type of FDA-approved bi... |
41555912 | Imidacloprid exposure in rats induces cardiac inflammatory response through activating TLR4/NF-κB/NLRP3 and JAK/STAT signaling pathways: focus on the berberine-loaded nanoliposomes. | The neonicotinoid insecticide, imidacloprid (IMI), is one of the widely used pesticides with well-documented serious health effects that are noticeable with long-term exposure. However, the long-term effects of IMI on cardiac tissues have not been fully elucidated. Herein, we investigated the mechanisms of IMI-induced ... |
41551764 | Construction of biomimetic gradient-structured cartilage organoids and mechanistic study of their application for cartilage rejuvenation. | Articular cartilage damage, an important cause of osteoarthritis (OA), is often caused by a senescent cartilage microenvironment and insufficient repair of chondrocytes. These effects are due to limited availability and a depleted stemness phenotype of chondrocyte stem cells, leading to the failure of cartilage repair ... |
41550559 | Halogen bonding and hydrogen bonding fluorescent anion sensing at the solid-liquid interface. | Halogen bonding (XB) has emerged as a powerful non-covalent interaction in anion supramolecular chemistry and is now well-established for the recognition and sensing of various environmentally and biologically relevant anionic species in solution. To translate the significant potential of XB-mediated anion binding to r... |
41550555 | Selective photocatalytic oxidative cleavage of terminal alkynes to carboxylic acids within a water-soluble Pd<sub>6</sub> nanocage. | The selective oxidative cleavage of terminal alkynes to carboxylic acids under mild, environmentally benign conditions remains a major challenge in catalysis due to the diverse reaction profile of terminal alkynes. Herein, we report a cavity-mediated UV light-driven oxidation of terminal alkynes to the corresponding ca... |
41550549 | Coupled dehydration and hydrogenation catalysis for one-pot conversion of saccharides into high-value furanic compounds. | The sustainable conversion of carbohydrates into furanic compounds (<i>e.g.</i>, 2,5-dimethylfuran, 2-methylfuran and furfuryl alcohol) through coupled dehydration and hydrogenation represents a pivotal route for biomass valorization. This review systematically summarizes recent advances in catalytic systems enabling t... |
41534348 | Multiplexed discrimination and ultrasensitive determination of pesticides using a Cu-O-Mo nanozyme tri-channel array driven by machine learning. | Nanozyme-based multichannel sensors integrated with machine learning (ML) often operate as "black boxes," lacking interpretability between analytical outputs and underlying molecular mechanisms. To address this, we developed a polyoxometalate-functionalized MOF featuring Cu-O-Mo bridging motifs, which integrates strong... |
41522519 | Bacterial diversity in the jelly of shark Ampullae of Lorenzini: a holobiont perspective. | The Ampullae of Lorenzini (AoL) are specialized electrosensory organs found in sharks and other chondrichthyans. They allow the detection of electric fields, temperature changes, and salinity variations. These organs contain a jelly composed of mucopolysaccharides, proteins, and ions, whose microbiota had not been prev... |
41517248 | Influence of Cross-Regional Cultivation on the Flavor Characteristics of <i>Pyropia haitanensis</i>. | Geographical relocation can alter flavor quality in marine crops. Here, the same cultivar of <i>Pyropia haitanensis</i> ("ZHEDONG 1") was cultivated at six sites spanning northern to southern China, and taste- and odor-active compounds were characterized by LC-MS and GC×GC-TOFMS together with environmental measurements... |
41516773 | Real-Time Fluorescence-Based COVID-19 Diagnosis Using a Lightweight Deep Learning System. | The coronavirus is highly contagious, making rapid early diagnosis essential. Although deep learning-based diagnostic methods using CT or X-ray images have advanced significantly, they still face limitations in cost, processing time, and radiation exposure. In addition, for the possibility of real-time COVID-19 diagnos... |
41516426 | Spectroscopic Analysis of the TiO<sub>2</sub> Nanoparticles Influence on the Interaction of 5,10,15,20-(Tetra-4-carboxyphenyl)porphyrin with Human Serum Albumin. | Photodynamic therapy is a cancer treatment that relies on a photosensitizer (PS) to generate reactive oxygen species upon light activation, thereby destroying cancer cells. The photophysical properties of porphyrins make them effective PSs, while nanoparticles (NPs) enhance their delivery and stability. The bioavailabi... |
41515874 | Controlled Synthesis and Formation Mechanism of Uniformly Sized Spherical CeO<sub>2</sub> Nanoparticles. | As the core abrasive in chemical mechanical polishing (CMP) processes, the morphology, size uniformity, and chemical reactivity of CeO<sub>2</sub> nanoparticles (NPs) are crucial factors determining the surface precision and yield of devices. In this work, a KNO<sub>3</sub>-LiNO<sub>3</sub> eutectic molten salt was use... |
41515870 | Synthesis and Characterization of Water-Soluble EDTA-Crosslinked Poly-β-Cyclodextrins Serving as Ion-Complexing Drug Carriers. | Water-soluble poly-β-cyclodextrins (PCDs), crosslinked with ethylenediaminetetraacetic acid dianhydride (EDTADA), were synthesized at varying β-CD:EDTADA molar ratios (1:6, 1:9, 1:12, 1:15) to develop multifunctional nanocarriers with the ability to complex drugs, polymers, and ions. All PCDs exhibited nanometric parti... |
41515869 | A Review of Femtosecond Laser Processing for Sapphire. | Sapphire (α-Al<sub>2</sub>O<sub>3</sub>) has been widely used in high-power lasers, optical windows, semiconductor substrates, radomes, and other applications due to its exceptional optical properties, high hardness, excellent chemical stability, and thermal resistance. However, machining sapphire poses significant cha... |
41515492 | Viniferin-Rich Phytocomplex from <i>Vitis vinifera</i> L. Plant Cell Culture Mitigates Neuroinflammation in BV2 Microglia Cells. | Activation of microglia and resulting neuroinflammation are central processes that significantly contribute to neurodegenerative disease progression. Treatments capable of attenuating neuroinflammation are therefore an urgent medical need. <i>Vitis vinifera</i> L., cultivated since ancient times for its fruits, is know... |
41515487 | Green Extraction at Scale: Hydrodynamic Cavitation for Bioactive Recovery and Protein Functionalization-A Narrative Review. | Hydrodynamic cavitation (HC) is a green and readily scalable platform for the recovery and upgrading of bioactives from agri-food and forestry byproducts. This expert-led narrative review examines HC processing of citrus and pomegranate peels, softwoods, and plant protein systems, emphasizing process performance, ingre... |
41515113 | MeJA-Induced Plant Disease Resistance: A Review. | This review offers a comprehensive analysis of the extensive research on methyl jasmonate (MeJA)-induced plant disease resistance. It aims to elucidate the signal transduction pathways, interactions with other phytohormones, regulation of related gene expression, and the fundamental mechanisms contributing to plant dis... |
41515104 | Comprehensive Investigation of GRF Transcription Factors and Associated Responses to Drought Stress in Oat (<i>Avena sativa</i>). | Growth-regulating factors (GRFs) are plant-specific transcription factors that play important roles in plant growth and development. However, no systematic analysis of <i>GRF</i> genes has been reported in oat (<i>Avena sativa</i>). In this study, we conducted a comprehensive characterization of the <i>GRF</i> gene fam... |
41512646 | Determination of nucleosides in serum by two-dimensional magnetic solid-phase extraction microfluidic chip/liquid chromatography-mass spectrometry. | A two-dimensional magnetic solid-phase extraction microfluidic chip (2D-MSPE-chip) was designed in this paper. A microcolumn array was integrated before two serially connected extraction chambers to filter particles in the sample. The two magnetic nanomaterials with orthogonal separation mechanism of Fe<sub>3</sub>O<su... |
41512524 | Robust self-healing superhydrophobic coating for anti-icing. | Superhydrophobic surfaces are prone to structural damage and degradation of low-surface-energy substances, which significantly affects their long-term stability and performance in anti-/de-icing applications. Inspired by the self-recovery capability of lotus leaves, a migration of low-surface-energy substance-mediated ... |
41511269 | Molecular Dynamics Simulation of Nano-Aluminum: A Review on Oxidation, Structure Regulation, and Energetic Applications. | Nano-aluminum (nAl), characterized by its high combustion enthalpy and enhanced reactivity, serves as a critical component in advanced energetic materials like solid propellants and micro-ignition devices. However, the atomic-scale mechanisms governing its core-shell structure evolution, oxidation dynamics, and interfa... |
41511270 | Sustainable Carbon Nanomaterials from Biomass Precursors: Green Synthesis Strategies and Environmental Applications. | Environmental pollution caused by industrialization and population growth has intensified the demand for sustainable materials capable of mitigating contaminants effectively. In this context, the green synthesis of carbon-based nanomaterials derived from biomass has gained significant attention as an eco-friendly and r... |
41506111 | A nitrogen-rich Eu-MOF for ultrasensitive fluorescence detection of 6-mercaptopurine and 6-thioguanine. | The simultaneous detection of toxic antineoplastic drugs 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG) remains challenging due to their low intrinsic luminescence and low quantum yield. To address this, a novel three-dimensional europium-based metal-organic framework, Eu2-tbia, was rationally constructed using a tri... |
41505978 | Engineering ruthenium(II)-based nanoparticles for synergistic sonodynamic therapy with multi-targeted redox catalysis. | Sonodynamic therapy (SDT) could effectively overcomes the wavelength and energy limitations inherent to photodynamic therapy (PDT). However, current strategies for sonosensitizer optimization predominantly focus on acceptor engineering through extensive π-extension, which inadvertently compromises biocompatibility. Her... |
41503497 | MoS<sub>2</sub>-functionalized sulfonated polystyrene for adsorption of rhodamine B. | A novel MoS<sub>2</sub>-incorporated sulfonated polystyrene composite (MOSP) is developed for the selective removal of rhodamine B (RhB) from aqueous solutions. The materials are characterized using SEM-EDS, XRD, Raman spectroscopy, FTIR, CHNS elemental analysis, BET, and TGA, while UV-visible spectrophotometry and ICP... |
41498113 | A Structural Landscape Depiction of Dynamic Stability Centers of Local Structure in Protein Thermostability Engineering. | Engineering protein thermostability is a key aspect of rational protein design, aiming to broaden the applicability of enzymes and enhance their industrial utility. In this study, we introduce a strategy for identifying and reinforcing dynamic stability centers of local structure (DSCLSs) to improve protein thermostabi... |
41497182 | Room-temperature superprotonic conductivity in COOH-functionalized multicomponent covalent organic frameworks. | In solid materials, the development of hydrogen bonding (H-bonding) networks within pores is crucial for efficient proton conductance. In this study, a chemically stable carboxylic acid-functionalized, quinoline-linked 2D microporous covalent organic framework (COF) (Qy-COOH) was synthesized using the Doebner multicomp... |
41497179 | Wireless nanopore electrodes (WNEs): from a non-contact conductive tip to applications in electroanalysis and electrocatalysis. | Wireless nanopore electrodes (WNEs) exploit bipolar electrochemistry to provide stable and reproducible nanoscale electrochemical interfaces. The conductive material at the nanopore tip serves as a well-defined sensing interface. This feature enables high spatial and temporal resolution while eliminating the need for t... |
41496847 | Dual-ligand europium-based metal-organic frameworks and hydrogels for sensitive ratiometric fluorescent detection of tetracyclines in food. | Tetracycline (TC) residues in animal-derived foods pose potential risks to human health; thus, the establishment of detection methods with high accuracy, strong sensitivity, and easy operation is of considerable importance. Within the present work, a dual-emission fluorescent probe derived from a dual-ligand europium-b... |
41496843 | Tuning mesophase topology in hydrogen-bonded liquid crystals <i>via</i> halogen and alkyl chain engineering. | This study explores the influence of halogen substitution and alkyl chain length on the liquid crystalline properties of hydrogen-bonded supramolecules. Three series of hydrogen-bonded liquid crystals (HBLCs) were synthesized by combining 4-alkoxyphenylazopyridines as proton acceptors with varying alkyl chain lengths a... |
41496836 | Metal-based triazoles as a medical marvel of the modern era: a comprehensive review. | Antimicrobial resistance is raising serious health concerns across the globe, and its adverse effects are elevating day by day. Researchers are making efforts to find new and more efficient pharmaceutical agents to overcome this growing challenge. Metal-based drugs are very useful in this regard, and hence, they are ga... |
41496831 | Unlocking the potential of mandelic acid derivatives: chemical and biological applications - a comprehensive review. | Mandelic acid, an aromatic α-hydroxy acid first identified in 1831, has become a valuable scaffold in synthetic, medicinal, and industrial chemistry. Its aromatic ring, carboxylic acid group, and stereogenic centre provide a rare combination of chemical reactivity and stereochemical control, enabling the creation of st... |
41496824 | Engineering <i>ε</i>-polylysine-based photodynamic therapy agents with oxygen carrying and membrane-targeting capabilities for enhanced therapy under hypoxic conditions. | Photodynamic therapy (PDT) offers exceptional spatial and temporal precision, minimal invasiveness, and negligible side effects. However, the hypoxic microenvironment of tumors greatly limits the effectiveness of conventional photodynamic therapy (PDT) and severely reduces its therapeutic efficiency. Here, a simple and... |
41494391 | Feasibility of atmospheric water harvesting and generation technologies: Bridging innovation and market adoption. | Atmospheric water harvesting and generation (AWH-AWG) technologies constitute an emerging class of decentralized water supply systems, with the potential to complement or substitute conventional surface and groundwater sources. This article presents a critical and integrated assessment of AWH-AWG technologies based on ... |
41494239 | Nanotechnology for atherosclerotic plaque stabilisation: bridging innovation and clinical practice. | Vulnerable plaques, also known as high-risk plaques, are the main cause of acute cardiovascular events. Advances in nanotechnology have made it possible to monitor and stabilise these plaques. This review outlines the pathophysiological basis of vulnerable atherosclerotic plaques and explores the emerging role of nanop... |
41492244 | Multidirectional Charge Separation in Self-Assembled Aggregates of Perylenebisimide-Porphyrin Bola-Supra-Amphiphiles. | We report on the synthesis of a hydrogen-bond mediated bola-type supra-amphiphile and assembly thereof in water. The assembly is based on amphiphilic porphyrins and hydrophobic perylenebisimdes (PBI), which both form the resulting bola-form solely through the H-bonding motif, which is shielded by the assembly of the ch... |
41492203 | Silent Partners in the Mill: Unveiling the Role of Additives in Mechanochemical Synthesis. | Mechanochemistry has attracted significant attention as a sustainable and efficient alternative to solution-based synthesis, offering the advantage of solvent-free conditions or the use of only minor amounts of solvent. Many established mechanochemical transformations rely on the use of additives-a strategy broadly ref... |
41492043 | Bio-Inspired Laccase-Mimicking Cu<sub>3</sub>-MOF Nanozyme as Colorimetric Sensor Array for Rapid Degradation and Visual Sensing of Phenolic Compounds. | Trinuclear copper complexes that emulate the active sites of multicopper oxidases (MCOs) are of broad biological interest. Here, a monoatomic-node strategy combined with solvent reduction was used to construct a rare trinuclear copper MOF featuring a planar, equilateral-triangular Cu<sup>I</sup> <sub>0.6</sub>Cu<sup>II... |
41492020 | Sphingosine kinase 1 is integral for elastin deficiency-induced arterial hypermuscularization. | Deficiency of elastin (ELN), the major component of elastic fibers, leads to excess smooth muscle cells (SMCs), which characterizes arterial diseases (for example, supravalvular aortic stenosis (SVAS)) as well as physiological ductus arteriosus (DA) closure. Here we demonstrate that sphingosine kinase 1 (SPHK1) is a ke... |
41492010 | Network pharmacology and molecular docking reveal mechanisms of amiodarone-induced pulmonary fibrosis. | Pulmonary fibrosis is a common end-stage outcome of various chronic lung diseases, characterized by excessive extracellular matrix deposition, alveolar structural destruction, and progressive loss of pulmonary function. Despite advances in understanding its pathogenesis, effective therapeutic options remain scarce, hig... |
41491970 | Application of nanoparticles in the therapeutic management of endometrial cancer. | The management of endometrial cancer (EC) remains challenging due to metastatic risk, therapeutic resistance, and the modest durability of standard regimens. Nanotechnology offers a promising avenue to overcome these limitations by enhancing tumor-selective drug delivery, enabling controlled release, and facilitating m... |
41491842 | RO4938581, a GABA<sub>A</sub>-α5 negative allosteric modulator rescued behavioral and EEG phenotypes of a mouse model of Dup15q syndrome. | We investigated the correlation between increased gene copy number of gamma aminobutyric acid type A (GABA<sub>A</sub>) receptor α5-containing subunits and electrophysiological and behavioral phenotypes in a mouse model of Dup15q syndrome (15q dup) and tested the hypothesis that selectively inhibiting the activity of G... |
41491828 | Intrinsically disordered regions in the yeast transcriptional regulator Ixr1 support prion-like behavior. | Ixr1 is a yeast transcriptional regulator previously identified as a player in the response to stress conditions, such as oxidative stress, hypoxia, iron limitation or DNA damage. Little is known about the structure of the Ixr1 protein apart from their HMG-boxes, which conform two well-known folded DNA binding domains.... |
41491720 | Emerging nano-immunotherapeutic strategies achieve metastatic colorectal cancer precision therapy. | Metastatic colorectal cancer (mCRC) poses significant therapeutic challenges due to its low immunogenicity, complex metastatic patterns, and highly immunosuppressive tumor microenvironment. Despite the success of immune checkpoint blockade in MSI-H tumors, most mCRC cases remain unresponsive, underscoring the need for ... |
41491701 | Crystallisation of 1,2-dimethylimidazole, and 1-methylimidazole with organic acids. | Crystals of 1-methylimidazole and 1,2-dimethylimidazole with glutaric and succinic acids are described. The crystal structure including 1,2-dimethylimidazole and glutaric acid, has been reported previously, but the molecular salt of 1-methylimidazole with succinic acid were characterized for the first time in this stud... |
41491488 | Targeted Inhibition of P. gingivalis OMV-derived TsRNA by tetrahedral framework nucleic acids promotes periodontal regeneration. | Outer membrane vesicles (OMVs) derived from Porphyromonas gingivalis (P. gingivalis) exhibit substantially greater pathogenic potential than their parent bacteria, thereby contributing significantly to the pathogenesis of periodontitis. Herein, we investigated the influences of transfer RNA-derived small RNAs (tsRNAs) ... |
41491369 | Design and synthesis of graphite/Ni/Cu/triptorelin peptide electrocatalyst for hydrogen production and storage. | Hydrogen is a green energy carrier with high energy density. Its production and storage are facing challenges that have made researchers use different materials for its production and storage. Peptides are known to be very effective as the framework of metal cores for making electrocatalysts. Therefore, in this researc... |
41491277 | Engineering galactoside acetyltransferase for enhanced hesperetin-7-O-glucoside bioavailability. | Flavonoid glycosides exhibit compromised bioavailability due to low membrane permeability. To address this limitation, we acetylated flavonoids through enzymatic reactions to increase bioavailability. This study first reported that Hesperetin-7-O-glucoside (Hes-7-G) was acetylated by galactoside acetyltransferase (GAT)... |
41491200 | Reinvigorating CD8<sup>+</sup> T cells through ADRB1 blockade using copper-propranolol nanoparticles for enhanced immune checkpoint blockade therapy. | Currently, colorectal cancer ranks third in terms of global cancer incidence and second in terms of cancer-related mortality, posing a significant therapeutic challenge. However, the efficacy of immunotherapy is limited by the immunosuppressive tumor microenvironment, which is driven in part by T cell exhaustion. Herei... |
41491052 | Mapping GlycoRNAs on an Exosomal Surface. | This study introduces an innovative periodate oxidation and oxime ligation (OL) method in combination with RNA-binding dyes or molecular beacons (MB) to detect glycoRNAs on endosome-derived exosome surfaces, addressing the challenges posed by exosomes nanoscopic dimensions and the lack of suitable detection techniques.... |
41491013 | Ligand-Engineered Rearrangement of Active Sites in Silver-Based MOFs for Improved CO<sub>2</sub> Capture. | Precise regulation of the coordination environment of active sites to optimize the physicochemical structure, electronic configuration, and orbital hybridization mode of active species is the core strategy for enhancing catalytic performance. In this study, using methylthio group-containing terpyridine ligands as build... |
41490805 | Design, Synthesis, and Biological Evaluation of the First Novel Macrocycle-Based FGFR Inhibitors That Overcome Clinically Acquired Resistance. | Alterations in the FGFR family act as oncogenic drivers for multiple pediatric and adult tumors, leading to the development and approval of several FGFR inhibitors. However, the on-target gatekeeper and "molecular brake" mutations confer clinically acquired resistance to the FDA-approved FGFR inhibitors, which presents... |
41490745 | Scalable Aqueous Synthesis of a Biological Robust Metal-Organic Framework for Ethanol-Water Separation. | Ultradry ethanol is widely and crucially used in industry, primarily owing to its excellent solvent properties, reactivity, relatively low toxicity, and volatility. However, trace amounts of water present within it can significantly diminish its efficacy. Herein, we designed a low-cost and green-synthesized metal-organ... |
41490573 | Asymmetric C-H Functionalization of Bicyclo[2.1.1]hexanes and Their 2-Oxa- and 2-Aza Derivatives via Rhodium Carbene Intermediates. | Bicyclo[2.1.1]hexanes have generated considerable interest in recent years as bioisosteres of benzene. In this article, a C-H functionalization approach is described to derivatize the bicyclo[2.1.1]hexanes. The approach relies on dirhodium-catalyzed C-H insertion by donor/acceptor carbenes, which proceeds in a highly d... |
41490450 | Engineering a Mechanoresponsive DNA Origami Capsule for Drug Delivery to Narrowed Arteries. | Since their inception, DNA origami nanostructures (DONs) have attracted great interest for their programmable geometry, nanoscale precision, and biocompatibility. Here, we present mechanoresponsive DONs designed for targeted drug delivery to narrowed or obstructed arteries. Unlike conventional systems triggered by bioc... |
41490155 | Computational Modeling and Self-Assembly Synthesis of Borazine-Based Free-Standing Molecular-Thin Films. | Boron-nitride-rich organic thin materials based on borazines have gained significant attention for their potential in nano(opto)electronic and energy storage devices. We address synthetic challenges in producing effective borazine-based thin films by proposing a dual theoretical and experimental protocol. This combines... |
41490121 | Precise Analysis of Surface Adsorption Process on TiO<sub>2</sub>/H<sub>3</sub>PW<sub>12</sub>O<sub>40</sub> during Photocatalytic Degradation through UV-Vis/SERS Technique. | While porous catalysts enhance photocatalytic efficiency through improved pollutant adsorption, conventional spectroscopic methods often conflate adsorption equilibria with degradation kinetics. This study pioneers the application of surface-enhanced Raman spectroscopy (SERS) in precisely tracking interfacial molecular... |
41490021 | Hyaluronic Acid-Gentamicin Hydrogel and pH Indicator Mediated by Mesoporous Silica Nanoparticles as Antibacterial and Indicatable Wound Dressings for Real-Time Monitoring of the Healing Process. | Real-time monitoring of the wound healing process is of significant importance for clinical wound care. Herein, indicatable wound dressings are facilely designed by using mesoporous silica nanoparticles (MSN) as the mediator, which acts as a "bridge" between the bromothymol blue (BTB) pH indicator and the hyaluronic ac... |
41489917 | Electrolyte-Dependent, "Microscopically Irreversible" H-Atom Transfer Kinetics of Ce-Based Metal-Organic Framework, Ce-MOF-808. | Redox reactions at the interface of metal oxides and protic electrolytes almost always involve protons and electrons in equal amounts. Given the stoichiometry, these proton-coupled electron transfer (PCET) reactions are thermochemically equivalent to net H-atom transfer (HAT) reactions. The correlation between the chem... |
41489841 | The BrRLP1-BrMDAR1 module regulates the resistance to downy mildew in Brassica rapa. | <h4>Key message</h4>BrRLP1 positively regulates the resistance to downy mildew in Brassica rapa by interacting with the monodehydroascorbate reductase BrMDAR1. Downy mildew is a devastating disease that severely affects the yield and quality in Brassica rapa. Receptor-like protein (RLP) is important for plants disease-... |
41489811 | Design, Fabrication, and Application of Stretchable Electronic Conductors. | Stretchable electronics have been recognized as intriguing next-generation electronics that possess huge market value, and stretchable electronic conductors (SECs) are essential for stretchable electronics, which not only can serve as critical functional components but also are the indispensable electronic connections ... |
41489768 | Harnessing albumin's natural tumor-targeting properties: nanoplatform strategies for triple-negative breast cancer therapy. | Triple-negative breast cancer (TNBC) represents the most aggressive breast cancer subtype and is characterized by the absence of estrogen receptor, progesterone receptor, and HER2 expression; this subtype affects approximately 12-20% of all breast cancer cases, with a disproportionately poor prognosis and limited thera... |
41489677 | Cobalt(II) Coordination Polymers for Highly Sensitive and Selective Turn-On Fluorescence Detection of Sulfamethoxazole. | Two novel Co(II)-based coordination polymers, [Co(HDNA)(bibp)(H₂O)]ₙ (CP1) and {[Co₃(DCPN)₂(4,4'-bibp)₃(H₂O)₄]}ₙ (CP2), were synthesized via hydrothermal reactions using H₃DCPN and different N-donor co-ligands. Structural analysis revealed that CP1 forms a 2D layered network, while CP2 adopts a 1D chain structure exten... |
41489656 | A Cocrystal Strategy for Harnessing UV-Responsive Endogenous Photosensitizer in Visible Light Photodynamic Therapy. | Photosensitizer plays a pivotal role in photodynamic therapy (PDT). Nonetheless, designing a photosensitizer activated by visible light from small molecules remains a significant challenge. Here, a supramolecular self-assembly donor-acceptor cocrystal is proposed as a feasible strategy to enhance the PDT of the photose... |
41489651 | In Situ Transformable Photothermal Targeting Chimeras for Spatiotemporally Controllable Protein Degradation and Combination Immunotherapy for Cancer. | Targeted protein degradation (TPD) technology has been extensively exploited for cancer therapy. However, current TPD approaches suffer from two major limitations that the lack of tissue and subcellular specificity for precise localization, and insufficient postdegradation benefits due to their reliance on single tradi... |
41489534 | Navigating the Endothelial Barrier: A Multiscale Framework for Precision Nanomedicine. | The vascular endothelium is the final and critical barrier that systemically administered nanoparticles (NPs) must navigate to reach their therapeutic targets. While the macroscale biodistribution patterns and general NP design principles have been extensively studied, there is a significant gap in understanding the me... |
41489498 | Inclusion Complexes of Colchicine with Acyclic Cucurbit[<i>n</i>]urils to Improve Its Photostability and Retain Anticancer Activity. | Colchicine is known for its significant anti-inflammatory, antigout, and anticancer activities, and recent research has increasingly focused on its potential cardiovascular protective effects. However, its poor photostability restricts its broader applications. To address this limitation, supramolecular host-guest enca... |
41489488 | Broadband-Responsive UiO-PPy MOF Micromotors for 3D Motion and Selective Dye Separation. | Light-driven micro/nanomotors (MNMs) have emerged as promising candidates for environmental remediation and related applications. However, conventional light-driven systems often suffer from poor light-harvesting efficiency, limited motion modes, and high fabrication costs, which hinder their practical employment. Here... |
41489472 | The Molecular Basis of Growth Control in Guanine Crystals. | Precise control over crystal morphology is a longstanding challenge in materials science, as crystal shape governs optical, mechanical, and electronic properties. In contrast, living organisms achieve remarkable control over crystal morphology, though the underlying mechanisms are not fully understood. Among the most c... |
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