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41489447 | Supramolecular Nanoassemblies Harness Radical Excited-State Cascade Electron Transfer for Selective CO<sub>2</sub> Photoreduction. | Mimicking the efficiency of natural photosynthesis for multielectron CO<sub>2</sub> photoreduction remains a central challenge in solar fuel research. Toward this goal, we developed herein a noble metal free supramolecular ion-pair assembly comprising rhodamine B (RB), an underexplored organic photosensitizer, and a co... |
41489449 | Modular Synthesis of Chiral Multi-Substituted Cyclohexanes via Cobalt-Catalyzed Enantioselective Desymmetrizing Hydroalkylation. | Chiral, multi-substituted six-membered carbocycles with high sp<sup>3</sup> character are privileged frameworks in pharmaceuticals, agrochemicals, and natural products, owing to their enhanced binding affinity, metabolic stability, and three-dimensional molecular recognition. However, the enantioselective construction ... |
41489369 | Adaptation differences and mechanisms of influenza viruses to ANP32 proteins across species. | Avian influenza virus cross-species infection in humans poses a major threat to global public health. Species-specific differences between avian ANP32A and mammalian ANP32 proteins create a natural barrier against viral cross-species infection by directly impairing the functional interaction between the avian-origin vi... |
41489368 | Pre-assembled complexes and allosteric effects: parallels between eukaryotic phosphorylation cascades and membrane fusion during herpesviral entry. | Unlike most enveloped viruses, <i>Herpesviridae</i> distribute cell entry functions across several viral envelope proteins. The prevailing model posits that, upon interaction with the target cell, the activating signal is transmitted from the receptor-binding to the fusion-mediating component in a signaling cascade tha... |
41489351 | A Cascade ROS Nanoamplifier for Enhanced Sono-Chemodynamic Therapy of Osteosarcoma. | The cascade amplification of reactive oxygen species (ROS) production plays a vital role in enhancing the effectiveness of sonodynamic/chemodynamic therapy (SDT/CDT) for osteosarcoma. Nevertheless, the currently developed sonosensitizers and nanozymes face challenges such as low ROS production efficiency, poor stabilit... |
41489345 | Integrated Lead/Iodine Management for Sustainable Perovskite Solar Modules. | The environmental hazards posed by the release of toxic lead ions (Pb<sup>2+</sup>) and volatile iodine species remain a major obstacle to the large-scale commercialization of perovskite solar modules. Here, we propose a dual-function adsorbent-porphyrin-modified whitlockite nanocomposites (WH&Por), which simultaneousl... |
41489341 | Phenylpyridine-Based Borenium Salts as Lewis Acid Catalysts for Homocoupling of Diaryldiazomethanes. | Cationic borenium salts have emerged as powerful Lewis acids, but their potential in carbon-carbon bond formation remains largely unexplored. Here, we report the synthesis of a family of sterically and electronically differentiated arylpyridine-based borenium species prepared by controlled hydride elimination and subse... |
41489296 | A Dual Luminescent and Chromogenic Pt-NCN Complex for the Detection of GTP and CTP in Aqueous Media. | Selective recognition of nucleotides by synthetic receptors in aqueous media is an important area in supramolecular analytical chemistry due to their key biochemical functions. However, selective receptors for GTP and CTP remain an ongoing challenge. Herein, a water-soluble [Pt(NCN)Cl] complex (NCN = 1,3-bis(benzimidaz... |
41489304 | Molecular Decoupling and Surface Coverage Synergistically Contribute to the Volcano-Shaped Probability of Single-Molecule-Level Chemical Reactions at the Surface. | Deciphering single-molecule-level chemical reactions at surfaces requires elucidating the synergistic effect of molecular decoupling and spatial distribution. However, this can only be achieved using a limited number of experimental techniques. Here, we demonstrate for the first time that nanocavity-enhanced sum-freque... |
41489257 | Total Synthesis and Structural Revision of Keenamide A. | Stereochemical assignments of thiazoline-containing cyanobactins, a family of ribosomally synthesized and post-translationally modified peptides, are often complicated due to the propensity of the exomethine and C-4 chiral centers of thiazolines to epimerize under basic and acidic conditions. In this work, we re-evalua... |
41489039 | Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration. | Providing biomaterials with cell-instructive cues represents a major goal in tissue engineering to tailor cell-material interactions and guide tissue regeneration. For bone tissue regeneration, this has been classically addressed by integrating integrin-binding proteins and peptides on different substrates, aiming at m... |
41487065 | Self-Assembled Myricetin-Arginine Conjugate Nanozymes for Targeted Suppression of Joint Inflammation and Osteoclastogenesis in Rheumatoid Arthritis. | Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by synovial inflammation and progressive joint destruction driven by macrophage polarization and osteoclast activation. Current therapies lack lesion-specificity and cause systemic side effects, highlighting the need for targeted treatment strateg... |
41487051 | From Solution to Surface: How the Catalytic Environment Modulates Peptide Bond Cleavage by Metal-Oxo Cluster Nanozymes. | Nanozymes that selectively cleave proteins offer a promising alternative to natural proteases due to their superior stability, tunability, and scalability. However, they are either water-soluble, preventing efficient recovery and limiting their practical application, or structurally ill-defined and insoluble, hindering... |
41486407 | Sandwich-Architected Hybrid Organic Crystals with Humidity-Temperature Sensing and Cryogenic Photothermal Actuation. | The growing demand for personalized health care, smart wearables, and advanced environmental monitoring has spurred the development of multifunctional materials that combine flexibility, environmental adaptability, and diverse functionalities. However, conventional materials often failed to integrate these attributes s... |
41486400 | Pro-resolving lipid mediators in diseases: exploring the molecular basis and clinical implication. | Inflammation resolution is now understood as an active and highly coordinated biological process rather than a passive decline in inflammatory signals. When this program fails, inflammation may become persistent and gradually shift to a chronic pathological state. Such unresolved inflammation is increasingly recognized... |
41486406 | Innovative Strategies to Overcome Stability Challenges of Single-Atom Nanozymes. | Single-atom nanozymes (SAzymes) exhibit exceptional catalytic efficiency due to their maximized atom utilization and precisely modulated metal-carrier interactions, which have attracted significant attention in the biomedical field. However, stability issues may impede the clinical translation of SAzymes. This review p... |
41486350 | Scalable Manufacturing and Precise Patterning of Perovskites for Light-Emitting Diodes. | Owing to the exceptional optoelectronic properties, metal halide perovskites have emerged as leading semiconductor materials for next-generation display technologies, providing perovskite light-emitting diodes (PeLEDs) great potential for high-quality color displays with a wide color gamut and pure color emission. Alth... |
41486342 | Mitochondria as a therapeutic target in neurodegeneration caused by hypoxia and ischemia during the perinatal period. | Perinatal hypoxia, also known as neonatal hypoxia-ischemia (HI), can pose a significant threat to the life and health of newborns, leading to hypoxic-ischemic encephalopathy (HIE) and numerous organ dysfunctions, including the nervous system. Mitochondria, which are key organelles in maintaining cellular homeostasis, a... |
41486344 | Confining Li⁺ Solvation in Core-Shell Metal-Organic Frameworks for Stable Lithium Metal Batteries at 100 °C. | The practical deployment of lithium metal batteries remains severely constrained, especially under elevated temperatures. Although metal-organic frameworks (MOFs) improve the thermal stability of liquid electrolytes by capturing them in well-ordered sub-nanopores, interparticle voids between MOF particles readily absor... |
41486346 | Hydrogel Electrolytes for Zinc-Ion Batteries: Materials Design, Functional Strategies, and Future Perspectives. | With the escalating demand for safe, sustainable, and high-performance energy storage systems, hydrogel electrolytes have emerged as promising alternatives to conventional liquid electrolytes in zinc-ion batteries. By integrating the high ionic conductivity of liquid electrolytes with the mechanical robustness of solid... |
41486343 | Halide Perovskite Heterostructures for High-Performance Light-Emitting Diodes. | Metal halide perovskites have emerged as highly promising candidates for the emissive layer in next-generation light-emitting diodes (LEDs) due to their narrow emission linewidths, high photoluminescence quantum yields, and tunable emission wavelengths. Achieving high-performance perovskite LEDs (PeLEDs) requires the e... |
41486294 | Mitophagy in the pathogenesis and management of disease. | Mitophagy, an evolutionarily conserved quality-control process, selectively removes damaged mitochondria to maintain cellular homeostasis. Recent advances in our understanding of the molecular machinery underlying mitophagy - from receptors and stress-responsive triggers to lysosomal degradation - illustrate its key ro... |
41486244 | Self-Assembly Control of Y-Series Non-fullerene Acceptors for Sustainable and Scalable Organic Photovoltaics. | Sustainability and scalability remain critical hurdles for the commercialization of organic solar cells (OSCs). However, addressing both poses challenge. Herein, we introduce a simple yet effective strategy utilizing 3,5-dichloropyridine (PDCC) as a solid additive to fine-tune the self-assembly behavior of Y-series non... |
41486237 | Harnessing the Power from Ambient Moisture with Hygroscopic Materials. | Moisture electricity generation (MEG) has emerged as a sustainable and versatile energy-harvesting technology capable of converting ubiquitous environmental moisture into electrical energy, which holds great promise for renewable energy and constructing self-powered electronics. In this review, we begin by outlining th... |
41486210 | Interface Engineering Strategies for Shuttle Mitigation in Alkali Metal-Sulfur Batteries: A Comparative Review from Li-S to Na-S and K-S Systems. | Rechargeable alkali metal-sulfur (M-S) batteries, including Li/Na/K-S chemistries, have the potential to utilize abundant and low-cost sulfur cathodes yet offer high theoretical energy densities. However, their practical electrochemical performance is fundamentally limited by the polysulfide shuttle effect. This challe... |
41486213 | Multifunctional Dipoles Enabling Enhanced Ionic and Electronic Transport for High-Energy Batteries. | Achieving high-energy density remains a key objective for advanced energy storage systems. However, challenges, such as poor cathode conductivity, anode dendrite formation, polysulfide shuttling, and electrolyte degradation, continue to limit performance and stability. Molecular and ionic dipole interactions have emerg... |
41486123 | Transcriptomics identified crucial candidate genes and pathways regulating early testicular development of drakes in the hypothalamic-pituitary-gonadal/thyroid axes. | <h4>Background</h4>The crosstalk between the hypothalamic-pituitary-gonadal (HPG) and hypothalamic-pituitary-thyroid (HPT) axes plays an important role in gonadal development. However, the mechanism by which these 2 axes regulate early testicular development in drakes remains largely unknown. Therefore, the aim of the ... |
41201058 | <i>Nanoscale Horizons</i> Emerging Investigator Series: Dr Fangfang Cao, Beihang University, China. | Our Emerging Investigator Series features exceptional work by early-career nanoscience and nanotechnology researchers. Read Fangfang Cao's Emerging Investigator Series article 'MOF-derived nanozymes loaded with botanicals as multifunctional nanoantibiotics for synergistic treatment of intracellular antibiotic-resistant... |
41200810 | Spermine-responsive supramolecular DNA nanogels loaded with dual drugs for potential combined cancer therapy. | The construction of nano-drug carriers based on deoxyribonucleic acid (DNA) has demonstrated significant therapeutic potential. Similarly, supramolecular therapeutic systems utilizing host-guest interactions have emerged as promising in nanomedicine. Building upon these approaches, we designed a size-controllable, mult... |
41189547 | Efficient methane to ethane conversion <i>via</i> C-H bond activation catalyzed by a MOF-derived porous PdO/TiO<sub>2</sub> nanocomposite. | The photocatalytic conversion of methane (CH<sub>4</sub>) into high-value multicarbon (C<sub>2+</sub>) products under ambient conditions provides a highly promising approach for the transformation of the energy structure and environmental protection. However, the high C-H bond dissociation energy of CH<sub>4</sub> and ... |
41148632 | Gene silencing regulated by aggregates of Corn aptamer at 3' UTR of mRNA. | Gene therapy, as a cutting-edge approach for disease intervention, relies heavily on advancements in gene silencing techniques. For instance, CRISPR-Cas9 has emerged as a leading gene-editing tool due to its ability to introduce precise cuts at specific genomic loci, enabling targeted gene insertion, deletion, or modif... |
41143624 | Supramolecular DNA/amino acid-based oxidase-mimetic nanocatalysts exhibiting drug degradation capability. | Developing efficient and environmentally benign approaches for the remediation of antibiotic pollutants has become a paramount research imperative, since the extensive use of antibiotics has raised serious concerns due to their potential to induce antibiotic resistance and disrupt the ecological balance. In this work, ... |
41024635 | Surface nanostructures regulated by chalcogen bonding interactions. | In recent years, chalcogen bonding (ChB) has emerged as a versatile tool for the bottom-up construction of functional nanostructures on surfaces. This minireview systematically explores the fundamental principles and recent advancements in ChB-directed on-surface synthesis. We highlight how ChB, characterized by its st... |
41768294 | Heat Flow in Solvent-Free, Dense Amorphous and Semi-Crystalline Cellulose Derivatives. | Polymers are essential in our everyday life due to their versatility and tunable properties, but common synthetic polymers pose significant environmental challenges. This has led to growing interest in natural, biodegradable alternatives such as cellulose. For cellulose to serve as a viable alternative, it must match o... |
41617290 | A dual-functional konjac glucomannan-based packaging system constructed from supramolecular co-assembly emulsion crosslinked natural pigment for monitoring and preservation. | In this study, gelatin-caffeic acid (Gel-CA) conjugates were synthesized via covalent crosslinking and subsequently used to formulate thyme essential oil (TEO)-loaded Pickering emulsions (GCTP). These GCTP emulsions, together with purple potato anthocyanin (Ant), were incorporated into a structured konjac glucomannan (... |
41600837 | Enterovirus D68 Sequence Variations and Pathogenicity: A Review. | Enterovirus D68 (EV-D68), a neurotropic respiratory pathogen, poses a considerable clinical threat through its link to pediatric acute flaccid myelitis (AFM) and severe respiratory illness. The possibility of recurrent epidemics, evidenced since the 2014 outbreak, remains a major concern. Genomic determinants of virule... |
41599696 | Jaceosidin Attenuates Sepsis-Induced Myocardial Dysfunction by Promoting SIRT2-Mediated Inhibition of Histone H3K18 Lactylation. | <b>Background:</b> Sepsis-induced myocardial dysfunction (SIMD) is a life-threatening complication with limited therapeutic options. Jaceosidin (JAC), a natural flavonoid from Folium Artemisiae Argyi, shows potential in cardiovascular diseases, but its role and mechanism in SIMD remain unclear. This study aims to inves... |
41599694 | Nanomedicine-Driven Therapeutic Strategies for Rheumatoid Arthritis-Associated Depression: Mechanisms and Pharmacological Progress. | Rheumatoid arthritis (RA) is frequently accompanied by depression, a comorbidity arising from the interplay of chronic systemic inflammation, neuroimmune activation, oxidative stress, and dysregulation of the gut-brain axis. Increasing evidence suggests that nanomedicine offers unique opportunities for the integrated m... |
41599172 | In Silico Studies and Biological Evaluation of Thiosemicarbazones as Cruzain-Targeting Trypanocidal Agents for Chagas Disease. | <b>Background/Objectives:</b> Chagas disease remains a major unmet medical need due to the limited efficacy and safety of current therapies. Here, we investigated sixteen thiosemicarbazone (TSC) derivatives as cruzain inhibitors using an integrated in silico/in vitro workflow. Methods: Docking against cruzain (PDB 3KKU... |
41599175 | PEGylated Zein Micelles for Prostate Cancer Therapy: Influence of PEG Chain Length and Transferrin Targeting on Docetaxel Delivery. | <b>Background/Objectives:</b> Docetaxel is a widely used chemotherapeutic agent for several malignancies and is an established treatment for castration-resistant prostate cancer. However, its poor aqueous solubility, systemic toxicity, and the emergence of drug resistance limit its clinical benefit. Zein, a prolamin, f... |
41599173 | Pharmacokinetics and Drug Interactions. | Adverse drug reactions-including those caused by drug-drug interactions (DDIs)-are a major cause of emergency department visits and subsequent hospitalizations in the United States, with studies estimating that 10-30% of these visits are drug-related [...]. |
41596125 | Targeting Oxidative Stress in Carcinogenesis: Oleanolic Acid and Its Molecular Pathways. | This narrative review aims to systematize the current knowledge on the dual role of reactive oxygen species and reactive nitrogen species in cancer processes, from their physiological function in redox signaling to their pathological impact in oxidative distress. The mechanisms of biomolecule damage, particularly DNA, ... |
41594624 | Phosphomimetic Thrombospondin-1 Modulates Integrin β1-FAK Signaling and Vascular Cell Functions. | Thrombospondin-1 (TSP1) is a multifunctional glycoprotein that plays a crucial role in angiogenesis and vascular remodeling. Ser93 of TSP1 has recently been identified as a novel phosphorylation site, influencing angiogenic properties; however, the underlying signaling mechanism remains unclear. Here, we investigated t... |
41594093 | Nitric Oxide-Releasing Gels in the Context of Antimicrobial Stewardship, Biofilm Management, and Wound-Repair Biology. | Topical antibiotics have long been used for the prevention and treatment of superficial skin and soft tissue infections; however, increasing evidence indicates that their clinical value is undermined by rising antimicrobial resistance, high rates of allergic sensitization, inadequate activity against biofilms, and a la... |
41590653 | A Comprehensive Review on Medium- and Long-Chain Fatty Acid-Derived Metabolites: From Energy Sources to Metabolic Signals. | Medium- and long-chain fatty acids (MLFAs) are increasingly recognized not only as metabolic substrates but also as precursors of diverse bioactive metabolites generated through host and microbial transformations. Recent advances in analytical chemistry and microbiome research have revealed that gut microorganisms cata... |
41590296 | Electrochemical Detection of Cancer Biomarkers: From Molecular Sensing to Clinical Translation. | Early cancer detection is crucial for improving survival rates and treatment outcomes. Electrochemical biosensors have emerged as powerful tools for early cancer detection due to their high sensitivity, specificity, and rapid detection capabilities. This review explores recent advancements (2015-2025) in electrochemica... |
41550567 | Cross-scale design of abiotic-biotic interfaces for semi-artificial photosynthesis. | By coupling semiconductor nanomaterials with living microbes, nanomaterial-microorganism hybrid systems (NMHSs) create powerful biohybrids that unlock new routes for efficient and sustainable solar-to-chemical conversion. Central to the performance of this system is the biotic-abiotic interface, where photoelectrons mu... |
41518919 | A density functional theory-driven multifunctional design of metal-organic framework decorated glass fiber filters for efficient air purification. | Advanced air filtration systems have attracted significant attention due to their high efficiency, broad application scope and long-term reliability in removing air pollutants. Density functional theory (DFT) has played a crucial role in exploring the removal mechanisms for air pollutants at the atomic level, thereby e... |
41516924 | Organocatalyzed Atom Transfer Radical (Co)Polymerization of Fluorinated and POSS-Containing Methacrylates: Synthesis and Properties of Linear and Star-Shaped (Co)Polymers. | Hybrid fluorinated copolymers containing POSS moieties along with fluorinated homopolymers were synthesized via organocatalyzed atom transfer radical (co)polymerization (O-ATRP) of fluoroalkyl methacrylate (<b>FMA</b>) and a POSS-based monomer (<b>IBSS</b>) using perylene as a photocatalyst. Linear and four- and eight-... |
41516770 | A 3D Microfluidic Paper-Based Analytical Device with Smartphone-Based Colorimetric Readout for Phosphate Sensing. | In this work, a 3D microfluidic paper-based analytical device (3D-µPAD) was developed for the smartphone-based colorimetric determination of phosphate in environmental samples. The assay relied on the formation of a blue-colored product (molybdenum blue) in the detection area of the 3D-µPAD upon reduction of the hetero... |
41516401 | Specific Recognition of Glycoproteins: Design Strategies and Application Prospects of Molecularly Imprinted Polymers. | Glycoproteins pose significant challenges for specific recognition due to their structural complexity and microheterogeneity. Molecularly imprinted polymers (MIPs) have emerged as promising synthetic receptors, offering high stability and tailorable recognition sites. This review specifically highlights and systematica... |
41516389 | Water-Dispersible Supramolecular Nanoparticles Formed by Dicarboxyl-bis-pillar[5]arene/CTAB Host-Guest Interaction as an Efficient Delivery System of Quercetin. | Supramolecular nanoparticles offer an efficient strategy to enhance the solubility, stability, and bioavailability of poorly water-soluble therapeutic molecules. In this study, water-dispersible SNPs were successfully prepared from dicarboxyl-bis-pillar[5]arene (<b>H</b>) and cetyltrimethylammonium bromide (CTAB) using... |
41516385 | Molecular Modeling and Gene Ontology Implicate SLC35F4 and SLC35F5 as Golgi-Associated Importers of Flavin-Adenine-Dinucleotide. | Solute carriers (SLCs) mediate cell- and organelle-specific import and export of nutrients and metabolites required for every biochemical process that occurs in a cell. Functional studies have ascribed activities to many human genes annotated as SLCs, but more than 100 SLCs remain orphans. Here, we applied a set of com... |
41515097 | Influence of β-Cyclodextrin on the Overall Antioxidant Activity and DPPH· Reaction Kinetics of Fresh Raspberry (<i>Rubus idaeus</i> L.) and Dehydrated Strawberry (<i>Fragaria</i> × <i>ananassa</i> Duch.) Extracts. | The influence of natural β-cyclodextrin (β-CD) on the overall antioxidant activity of berry extracts is presented in this study. Raw raspberry (<i>Rubus idaeus</i> L.) and β-CD-assisted dehydrated strawberry (<i>Fragaria</i> × <i>ananassa</i> Duch.) ethanolic extracts (RB and SB, respectively) were spectrophotometrical... |
41512810 | Recent progress in typical foodborne spore-forming bacteria detection. | Spore-forming bacteria are common foodborne pathogens known for their heat resistance and ability to form spores, making them difficult to eliminate. Their persistence poses risks to food safety and shelf life. Traditional detection methods are often time-consuming, labor-intensive, and have insufficient sensitivity. T... |
41512470 | An injectable dual-drug-loaded hydrogel for the treatment of bacterial endophthalmitis. | Bacterial endophthalmitis is a severe ocular infection that frequently leads to severe visual impairment or blindness. Current clinical treatments primarily rely on intravitreal antibiotics to eliminate pathogens; however, these often fail to control the excessive inflammatory response that contributes to irreversible ... |
41511268 | Structurally Dependent Self-Propulsion Behaviors of Pt-SiO<sub>2</sub> Micromotors. | The structural dependence of self-propelled motion in micro/nanomotors is essential for effectively predicting and controlling their dynamic behaviors. In this study, platinum-silica (Pt-SiO<sub>2</sub>) micromotors, with structures ranging from spherical Janus to dimer configurations, are fabricated through convention... |
41494604 | CD44-targeted lipid nanoparticles for enhanced CRISPR/Cas9 delivery in cancer gene editing. | Skin cancer is the third most common malignancy, with melanoma being the most challenging due to its resistance to current therapies. Gene editing technologies like CRISPR/Cas9 offer a promising strategy for targeting cancer-specific genes, but the efficient delivery of these tools to tumor sites remains a significant ... |
41486853 | NIR Light-Driven Photocatalytic Antibacterial Hydrogels for Synergistic MRSA Biofilm Eradication and Wound Regeneration. | The treatment of drug-resistant bacterial biofilm infections remains a significant challenge in clinical practice. To address this challenge, 3D oxygen vacancy (OV)-rich iron-doped Bi<sub>2</sub>O<sub>2</sub>S (Fe-Bi<sub>2</sub>O<sub>2-X</sub>S, Fe-BOS) nanoflowers (NFs) are synthesized for the first time via an ion-ex... |
41486849 | Bioinspired Microgel Assembly of Liver-Derived Decellularized Extracellular Matrix Enhances Dentin-Pulp Regeneration via Stemness Awakening. | Gradual loss of cellular potency during in vitro expansion is a primary challenge in the clinical translation of stem cell therapies. This decline in regenerative potential significantly compromises regenerative endodontic therapy (RET)-an emerging strategy for reconstructing dentin-pulp complex. Hence, we develop an i... |
41486840 | Organic Electrochemical Transistors for Neuromorphic Devices and Applications. | Neuromorphic engineering, an interdisciplinary field bridging bioelectronics and neuroscience, endeavors to address the bottleneck of the von Neumann architecture by constructing hardware-level artificial neural networks (ANNs) and replicate the complicated architecture and functionality of the human brain, heralding a... |
41486845 | A Dual-Piezoelectric Metal-Organic Cage/COF Z-Scheme Heterojunction for Solar-Mechanical Water Splitting. | Developing efficient solar-mechanical energy conversion systems is crucial for sustainable H<sub>2</sub>/H<sub>2</sub>O<sub>2</sub> production. We report an unprecedented piezoelectric metal-organic cage (MOC-FA3), integrated with piezoelectric β-ketoenamine COF (S-COF) into a Z-scheme heterojunction via supramolecular... |
41486814 | Intramolecular Synergy of CO<sub>2</sub> Activation and H Spillover on Heteronuclear Dual-Metal Phthalocyanine Assemblies for Selective CO<sub>2</sub> Photoreduction. | Solar-driven CO<sub>2</sub> conversion holds great promise in carbon recycling. CO<sub>2</sub> activation and hydrogen spillover are crucial for high-selectivity CO<sub>2</sub> reduction, while with great challenges. Here, heteronuclear metal phthalocyanine aggregates with atomically active sites are synthesized and th... |
41486822 | Engineering Biomimetic Nanoparticle Performance Through Fabrication Method Selection: Turbulent Jet Mixing, Microfluidics, and Extrusion. | Nanoparticle (NP) fabrication has advanced rapidly, driven by the growing role of nanomedicine in targeted drug delivery. Each fabrication strategy offers unique advantages and limitations. Here, we conduct a comparative evaluation of three prominent methods: turbulent jet mixing, microfluidic mixing, and extrusion, fo... |
41486758 | PGLa and Magainin 2 Can Porate Membranes via Transient Hourglass-Shaped Toroidal Pores. | Antimicrobial resistance has emerged as a significant global public health concern, necessitating prompt and comprehensive attention. In response to this pressing challenge, antimicrobial peptides (AMPs), which are innate immune system components naturally synthesized by diverse organisms, hold potential as alternative... |
41486755 | Expanded Boraporphyrinoids: Boron Macrocycles with Redox Switchable Magnetic (Anti)aromaticity and Strong Near-Infrared Absorption. | Synthetic porphyrinoids are an intensely researched class of organic chromophores that can exhibit exceptional optoelectronic properties such as efficient light-harvesting capabilities due to panchromatic absorption and high extinction coefficients as well as emission in the long-wavelength electromagnetic spectral reg... |
41486752 | Schwann Cell Synthesized Cholesterol Orchestrates Peripheral Nerve Regeneration via Structural and IGF1-Dependent Signaling Mechanisms. | Peripheral nerve myelin is the most cholesterol-rich structure in the body, with the majority of cholesterol being synthesized by Schwann Cells (SCs). Following peripheral nerve injury, myelin disintegration leads to substantial cholesterol release and accumulation, which has been suggested to aggravate neuroinflammati... |
41486730 | 3D-Printed Titanium Implants with Bioactive Peptide-Polysaccharide Scaffolds for Personalized Bone Reconstruction. | Large bone defects caused by trauma, tumor resection, or congenital abnormalities remain a major clinical challenge. Standard titanium implants are widely used due to their strength and biocompatibility, but their bioinert surfaces often lead to poor osseointegration. The emergence of 3D printing has enabled patient-sp... |
41486747 | Heterostructure-Engineered Conductive MOFs Coupled with MoSe<sub>2</sub>@MXene Framework for Efficient and Selective Lithium Extraction from Salt Lake Brine via Capacitive Deionization. | Sustainable recovery of lithium from salt lake brines is essential for the transition toward clean energy but remains challenged by low Li<sup>+</sup> concentrations and high Mg<sup>2+</sup> interference. Herein, we develop a heterostructure-engineered ternary composite, conductive metal-organic frameworks (c-MOFs) cou... |
41486736 | Single-Atom Cobalt Species on Curved Hollow Carbon Sphere: Breaking Linear Scaling Relationship Limitations in Electrocatalytic Deactivation of Dilute Antibiotic Pollutants. | Despite maximal atomic efficiency, single-atom catalysts (SACs) are constrained by linear scaling relationships in electrocatalytic hydrodechlorination (ECHD), a process effective for antibiotic pollutant deactivation yet challenged by multi-proton /electron transfer and dilute reactant conditions. Herein, a novel coba... |
41486703 | An All-Soft Wearable Electrochemiluminescence Chip for Sweat Metabolite Detection. | Wearable sensors are transforming real-time, non-invasive health monitoring. Despite considerable advances in electrochemical and optical sensing modalities, challenges remain in achieving reliable, sensitive, and cost-effective detection of sweat metabolites due to the variable chemical composition of sweat and diffic... |
41486704 | Doxorubicin-Loaded Metal-Organic Framework for Ferroptosis-Enhanced Chemotherapy Through Sustained Zn Release and Glutathione Peroxidase Downregulation. | As a cornerstone of cancer treatment, chemotherapy is frequently hindered by poor tumor specificity, systemic toxicity, and the emergence of drug resistance. These limitations underscore the need for innovative therapeutic strategies that can circumvent resistance mechanisms and enhance cancer cell cytotoxicity. Herein... |
41486701 | PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis. | Aberrant lipid metabolism characterizes the progression of breast cancer. Statins, the canonical agents for modulating this pathway, have been associated with improved overall survival in patients with triple-negative breast cancer (TNBC). However, their clinical benefit remains limited because the reversible inhibitio... |
41486669 | Visualizing and Quantifying Impact with Mechanochromic Sensing Paints Based on Self-Assembled Polydiacetylene-Silk Core-Shell Vesicles. | Rapid detection and quantification of mechanical impact on surfaces is relevant for many fields, as it enables monitoring of material stresses and integrity or to assess the physiological effects of force on humans for concussions, gait, or blast dosimetry, among others. Accurate and quantitative detection of impact fo... |
41486624 | EGaIn-Activated Bioinspired Silk Micro/Nanofibril Eutectogels Breaking the Strength-Conductivity Trade-Off for High-Performance Wearable Bioelectronics. | Eutectogels combining high mechanical and electrical performance hold great promise for next-generation wearable electronics. However, conventional polymerizable deep eutectic solvent (PDES)-based eutectogels suffer from an inherent strength-conductivity trade-off. Here, inspired by the multiscale architecture of the e... |
41486634 | Synthesis of Dibenzo[<i>a</i>,<i>e</i>]cyclooctatetraenes Enabled by a Palladium-Catalyzed Cross-Coupling Reaction. | Herein, we report a palladium-catalyzed cross-coupling reaction of sulfonylhydrazones with aryl or alkenyl halides, affording a diverse array of substituted dibenzo[<i>a</i>,<i>e</i>]cyclooctatetraenes featuring planar chirality. Substituents can be efficiently installed onto both aryl and alkene moieties. Preliminary ... |
41486625 | Exploring the Relationship between the Entropy Effect and Element Effect in High-Performance High-Entropy Materials. | High-entropy materials show significant potential in various fields. It is commonly recognized that the entropy stabilization effect and the element synergy effect jointly affect high-entropy materials. However, the debate yet persists over whether the entropy stabilized effect or element synergy dominates their perfor... |
41486619 | Learned Conformational Space and Pharmacophore Into Molecular Foundational Model. | The emergence of large-scale chemical pre-trained models has significantly advanced our ability to capture complex relationships between molecular structures and their functions. Despite the growing interest in molecular foundational model that provide versatile representations and support molecular optimization for do... |
41486597 | Hydrogen-Bonding Networks Enabled by Trace Water for Morphological Design in Ternary Organic Solar Cells. | Morphology evolution is critical to the performance of functional materials, but strategies for its control remain largely empirical. Here, we identify a counterintuitive role of water (H<sub>2</sub>O) as a morphology-regulating agent in ternary organic solar cells (OSCs), traditionally considered an impurity. Molecula... |
41486589 | Small Nucleolar RNA Snord17 Promotes Self-Renewal of Intestinal Stem Cells through Yy2 mRNA Export and Tead4 Activation. | The intestinal epithelium possesses a profound capacity for regeneration, which is fueled by the proliferation and differentiation of leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5)-expressing intestinal stem cells (ISCs) located at the base of the crypts. However, how small nucleolar RNAs (snoRNAs) ... |
41486590 | Harnessing RAFT Polymerization for Hierarchical Structuring of Thermosets by Direct Ink Writing. | Integrating molecular self-assembly with additive manufacturing has opened new avenues for the direct production of thermosetting polymers with intricate geometries and tailored microstructures. The wide range of available chemical compositions enables diverse applications for the materials, including nanostructured po... |
41486576 | Methylation-Induced Permanent Charge Polarization in Covalent Organic Frameworks for Visible Light-Driven Water Decontamination and Disinfection. | Covalent organic frameworks (COFs) show promise for photocatalytic environmental remediation and antibacterial applications; however, their efficiency is often constrained by strong excitonic effects that impede charge separation. Here, a targeted in situ methylation strategy is reported to engineer permanent cationic ... |
41486563 | A Natural Sweetener-inducible Genetic Switch Controls Therapeutic Protein Expression in Mammals. | Cell-based therapies are recognized as the next generation living therapeutics in medicine, especially through the design of synthetic gene switches to enhance the safety and controllability of engineered cells. However, current small molecule-regulated synthetic gene switches face clinical limitations such as long-ter... |
41486574 | Efficient Preservation of Perishable Fruits by Erasable Metal-Organic Frameworks. | With the worldwide crisis of food shortages, reducing postharvest losses in fruits and vegetables faces one of the greatest global challenges of contemporary food and agriculture. This study presented an erasable metal-organic framework (MOF)-based coating designed for dual functionality in combating foodborne pathogen... |
41486547 | Selective Confinement by a COF-Derived Sub-Nanoporous Interface for High-Performance CoF<sub>2</sub> Thermal Battery Cathodes. | The pervasive dissolution of transition metal fluoride (TMF) cathodes presents a fundamental barrier to their application in high-voltage thermal batteries and other Li<sup>+</sup>-conducting systems. Herein, we report a novel selective confinement strategy inspired by ion sieving to overcome this challenge by construc... |
41486519 | Redox Oligomer Assembling Hierarchical Reinforced Framework Cathodes for Ultra-Stable High-Performance Zinc-Ion Batteries. | Organic cathodes with maximal redox active-sites and structural tunability are in great demand for aqueous zinc-ion batteries (ZIBs). Currently, they are facing challenges of limited capacity, poor cycling stability, and sluggish ion transport in practical applications. In this work, we have developed a universal and e... |
41486524 | Multifunctional Gelatin-Based Smart Films Integrating Thermochromic Encryption, Temperature-Regulated Photothermal Management, Reprocessability, and Biodegradability for Sustainable Applications. | Multifunctional gelatin-based smart films are engineered by incorporating hyperbranched polyglycerol (HBPG) as a plasticizer, dialdehyde β-cyclodextrin (Da-β-CD) as a crosslinker, and thermochromic microcapsules (TCMs). Structural analyses, including FTIR, XPS, and NMR, confirm the formation of covalent Schiff base lin... |
41486206 | Development and optimization of polyoxometalate-modified metal-organic frameworks for efficient removal of sulfur and nitrogen compounds from diesel fuel under visible light. | As global fuel standards tighten, stripping sulfur and nitrogen compounds from diesel has emerged as a pivotal hurdle for both environmental protection and industrial innovation. This study explores an innovative route to synthesize metal-organic frameworks (MOFs) infused with Keggin-type polyoxometalates (Mo₆W₆), craf... |
41486149 | Post-translational modifications of immune checkpoints: molecular mechanisms, tumor microenvironment remodeling, and therapeutic implications. | Immune checkpoints play pivotal roles in regulating immune responses and maintaining tolerance. In cancer, these molecules are hijacked to suppress antitumor immunity, resulting in therapeutic resistance to immune checkpoint blockade (ICB). Recent advances have highlighted the critical role of post-translational modifi... |
41485229 | Halogen Bonds under Electric Field with Quantum Accuracy and Relativistic Basis Sets. | Halogen bonds (XBs) are a cornerstone of supramolecular chemistry, yet their response to external perturbations remains poorly investigated, particularly in systems with heavy elements where relativistic effects are significant. We benchmark two prototypical iodine-chloride X-bonded complexes, ClI···N(CH<sub>3</sub>)<s... |
41485156 | Self-Assembled Ordered Nanostructure of Zwitterionic Co-Solutes Induces Localized High-Concentration Electrolytes for Ultrastable and Efficient Zinc Metal Anodes. | Localized high-concentration electrolytes (LHCEs) are considered as promising electrolyte candidates to resolve technical issues of metal batteries owing to their unique interfacial properties and solvation structures. Herein, we propose a self-assembly chemical strategy into the LCHEs induced by ordered nanostructure ... |
41485129 | Steric Bulk Controls Δ/Λ Handedness Enabling Stereodivergent Self-Assembly of Fe<sup>II</sup><sub>2</sub>L<sub>3</sub> Cages. | Developing a stereodivergent approach to access chiral metal-organic cages is an appealing yet challenging goal in the field of supramolecular chemistry. In this work, we report a stereodivergent method for constructing chiral cages via subcomponent self-assembly of a chiral diamine, 3-substituted 2-formylpyridines, an... |
41484663 | Triboelectric Nanogenerators for Future Space Missions. | Space exploration is significant for scientific innovation, resource utilization, and planetary security. Space exploration involves several systems including satellites, space suits, communication systems, and robotics, which have to function under harsh space conditions such as extreme temperatures (- 270 to 1650 °C)... |
41484093 | Structure insight into FtsZ function maintaining under acid stress of Streptococcus mutans. | Understanding the acid resistance mechanism of S. mutans is crucial for preventing dental caries. FtsZ is the core protein for cell division in bacteria that can polymerize into Z-rings and drive cytokinesis. Our previous study revealed that the FtsZ in S. mutans (SmFtsZ) has higher self-assembly and GTPase activity un... |
41970719 | Carbon capture using chemical absorption: Absorbent intergenerational evolution, process innovation, and large-scale application. | Carbon capture via chemical absorption is critical for carbon neutrality but faces deployment barriers including high-energy consumption, high cost, and insufficient system integration. This review establishes a three-dimensional review framework including absorbent intergenerational evolution, process integration, and... |
41694223 | Progress in the application of conductive hydrogels in wound healing: a review. | Wound healing is a complex process in which an endogenous electrical field directs cellular migration and tissue restoration. Conventional dressings provide physical protection but cannot modulate endogenous bioelectrical signals. Conductive hydrogels address this limitation by combining the intrinsic properties of hyd... |
41623471 | Rational design of C<sub>2</sub>N based atomically dispersed catalysts for energy conversion applications. | C<sub>2</sub>N is an emerging two-dimensional graphene-like carbon nitride material that is distinguished by its high specific surface area, uniformly distributed N<sub>6</sub> cavities, excellent chemical stability, and tunable electronic structures. These properties make it an ideal support for atomically dispersed c... |
41600973 | West Nile Virus: Epidemiology, Surveillance, and Prophylaxis with a Comparative Insight from Italy and Iran. | <b>Background</b>: West Nile Virus (WNV) is a mosquito-borne flavivirus responsible for seasonal outbreaks in temperate and tropical regions, including Europe, the Mediterranean, and the Middle East. Its transmission via mosquitoes, particularly <i>Culex</i> species, poses persistent challenges to public health. Despit... |
41600834 | Examination of In Vivo Mutations in VP4 (VP8*) of the Rotarix<sup>®</sup> Vaccine from Shedding of Children Living in the Amazon Region. | Group A rotaviruses (RVAs) remain the leading cause of acute gastroenteritis (AGE) in young children in low- and middle-income countries. In Brazil, the oral attenuated RVA vaccine (Rotarix<sup>®</sup>), monovalent genotype G1P[8], is distributed by the national immunization program and has drastically reduced morbidit... |
41599692 | Pharmacological Insights and Technological Innovations in <i>Curcuma longa</i> L. and <i>Echinacea purpurea</i> (L.) Moench as Plant-Derived Immunomodulators. | Immune dysregulation and chronic inflammation are central contributors to many diseases. <i>Curcuma longa</i> L. and <i>Echinacea purpurea</i> (L.) Moench are widely used medicinal plants with extensive preclinical evidence supporting immunomodulatory effects. Their key metabolites, curcuminoids, turmerones, alkamides,... |
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