id stringlengths 4 8 | title stringlengths 1 642 | abstract stringlengths 50 17.9k |
|---|---|---|
41599170 | Advances in Nanotechnology-Based Topical Delivery Systems for Skincare Applications. | The growing demand for effective skincare products that can effectively target specific dermatological concerns has accelerated the development of advanced delivery technologies. Among them, nanocarrier-based topical delivery systems have gained significant attention for their ability to enhance the performance of skin... |
41590291 | Evolution of Biosensors and Current State-of-the-Art Applications in Diabetes Control. | Diabetes is a chronic metabolic disorder that poses a growing global health challenge, currently affecting nearly 500 million people. Over the past four decades, the rising prevalence of diabetes has highlighted the urgent need for innovations in monitoring and management. Traditional enzymatic methods, including those... |
41552423 | Integrated meta-analysis and sentinel surveillance: Global prevalence and risk factors for <i>Mycoplasma bovis</i> in cattle (2007-2023). | <h4>Background</h4><i>Mycoplasma bovis</i> (<i>M. bovis</i>) is a major pathogen of cattle and contributes to substantial economic losses worldwide. A comprehensive understanding of its global prevalence is lacking, hindering the development of effective control strategies.<h4>Objectives</h4>This study aimed to determi... |
41551809 | Self-assembly mechanisms of wheat gluten peptides: Modulating interfacial behavior and foaming properties. | Foam performance plays a critical role in food systems by influencing texture and stability. This study investigates how the self-assembly of wheat gluten protein peptides (WGPs) affects foaming behavior and interfacial properties. Self-assembled WGP gel nanoparticles (WGPM-NPs, 3-10 kDa) produced interfacial layers wi... |
41544440 | Research note: The chicken gut virome: Spatiotemporal dynamics and divergent responses to antibiotic versus phytogenic supplementation. | This study employed metagenomic sequencing data to comprehensively investigate the gut virome, with a focus on the bacteriophage communities (the phageome), across intestinal regions and developmental stages in 360 chickens. We characterized the spatiotemporal dynamics of phage communities and assessed the impact of ch... |
41519040 | Smartphone-assisted multicolor aptamer-lateral flow assay using trimetallic nanoprobes and enzyme-free signal amplification for ENR detection. | Nanozyme-mediated lateral flow assay (LFA) remains limited by monochromatic signals, which hampers rapid visual recognition in field testing. Intelligent detection of antibiotic is essential for ensuring food safety. Here, we proposed a reliable multicolor LFA tool for detecting enrofloxacin (ENR) residues. The strateg... |
41517225 | Fabrication, Characterization, and Transcriptomic Analysis of Oregano Essential Oil Liposomes for Enhanced Antibacterial Activity and Sustained Release. | This study prepared oregano essential oil-loaded liposomes (OEO-Lip) and systematically evaluated their physicochemical properties, stability, and antioxidant/antibacterial activities, along with the underlying mechanisms. Characterization revealed OEO-Lip exhibited a unilamellar vesicle structure with a particle size ... |
41516742 | Recent Progress in Advanced Electrode Materials for the Detection of 4-Nitrophenol and Its Derivatives for Environmental Monitoring. | It is understood that 4-nitrophenol (4-NP) and its derivatives/isomers, such as m-NP and o-NP, are considered toxic nitroaromatic pollutants that pose health risks for human beings and have negative impacts on the environment. Therefore, monitoring of 4-NP is of particular importance to avoid the negative impacts of th... |
41516370 | Extracellular Polymeric Substances Produced by Actinomycetes of the Genus <i>Rhodococcus</i> for Biomedical and Environmental Applications. | Extracellular polymeric substances (EPSs) produced by actinomycetes of the genus <i>Rhodococcus</i> play crucial roles in their ecological success, metabolic versatility, and biotechnological value. This review summarizes existing studies of <i>Rhodococcus</i> EPSs, emphasizing the biochemical composition, functional a... |
41515475 | Recent Advances of g-C<sub>3</sub>N<sub>4</sub>/LDHs Composite Photocatalysts in Water Pollution Treatment. | Water pollution poses a pressing global environmental threat, driving an urgent need for efficient, stable, and eco-friendly water treatment techniques. Semiconductor photocatalysis has emerged as a highly promising solution, utilizing solar energy to thoroughly degrade pollutants under mild conditions without secondar... |
41512667 | Research note: Exploring the effects of glycerol monolaurate on lipid metabolism in young broilers based on molecular dynamics simulation and 16S rRNA analysis. | This study aimed to investigate the effects of glycerol monolaurate (GML) on lipid metabolism in young broilers, with focus on the AMPKα1 protein and the cecal microbiota. A total of 144 one-day-old male Arbor Acres broilers were randomly assigned to two groups, with each group consisting of six replicates of twelve bi... |
41509540 | Effects of Blood Pressure and Antihypertensive Drugs on Rheumatoid Arthritis: A Mendelian Randomization, Network Pharmacology, and Experimental Validation. | <h4>Background</h4>We conducted a Mendelian randomization study in conjunction with a network pharmacology study to provide an analytical elucidation of the potential causal relationship between blood pressure and antihypertensive drugs and rheumatoid arthritis.<h4>Methods</h4>First, a Mendelian randomization analysis ... |
41499899 | Exploration of complex-based probe for pesticide residue detection: Specific recognition achieved via the synergistic effect of coordination water and supramolecular chains. | The rational design of molecular fluorescent probes from transition metal complexes is a promising chemical strategy, yet its deployment for detection pesticide residues remains largely unexplored. Herein, a novel fluorescent probe for the pesticide PDM is fabricated from the Salen-Zn complex [Zn(3,5-Cl-Salnptn) (H<sub... |
41490842 | Injectable multi-component hydrogel as an inhibitor of choline kinase α achieved the treatment of malignant ascites by inhibiting PI3K/AKT/mTOR signaling pathway. | <h4>Introduction</h4>Primary liver cancer remains the third leading cause of global cancer-related mortality, with hepatocellular carcinoma (HCC) constituting the predominant histological subtype. The development of malignant ascites in advanced HCC patients signifies metastatic progression and portends poor clinical o... |
41490677 | Biochemical insights into the alleviated inhibition on nitrogen metabolism by micro-and nano-plastics at the biocathode of bioelectrochemical systems. | In this work, the inhibition of microplastics (MPs, 50 μm) and nanoplastics (NPs, 50 nm) on denitrification at biocathode in bioelectrochemical system (BES), and the alleviated of this inhibition on nitrogen metabolism using algal biochar (ABC) were investigated. With the addition of biochar, it was found that nitrate ... |
41485377 | Investigation of the aggregation and assembly mechanisms of trace organic compounds and dissolved organic matter using a combined approach of molecular dynamics simulations and experiments. | This study constructed generalized molecular models for diverse dissolved organic matter (DOM) components (lipids, peptides, carbohydrates, lignin, tannins, low-molecular-weight aromatics/aliphatics) and trace organic contaminants (TrOCs with positive, neutral, and negative charges). Large-scale molecular dynamics (MD)... |
41484803 | Mesenchymal stem cell-derived extracellular vesicles in musculoskeletal regeneration: mechanisms, applications, and future prospects. | Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have emerged as promising cell-free therapeutic strategies for musculoskeletal regeneration. MSC-EVs, which are enriched with diverse cargos, exert multifaceted biological effects, including the modulation of inflammation, the promotion of angiogenesis, and... |
41484507 | HDL in Abdominal Aortic Aneurysm: Mechanistic Insight and Therapeutic Potential. | <h4>Purpose of review</h4>This review examines the role of high-density lipoprotein (HDL) in the context of abdominal aortic aneurysm (AAA). It focuses on the correlation between HDL and AAA risk, while also exploring the mechanisms by which HDL may protect against AAA progression.<h4>Recent findings</h4>Large epidemio... |
41484368 | Asymmetric envelope surface disposition of secreted protein YjbI controls bimodal antibiotic susceptibilities in C. crescentus. | Cytoplasmic pentapeptide repeat proteins (PRPs) protect bacterial DNA gyrase from quinolone antibiotics. While some secreted PRPs are essential upon quinolone exposure, their role in the regulation of antibiotic resistance remains to be fully characterized. We show that a YjbI-type secreted PRP regulates antibiotic sen... |
41484353 | Nanobodies as tools for studying human frataxin biology. | Iron-sulfur clusters are essential cofactors for the accurate cellular function of many proteins. In eukaryotic cells, the biogenesis of most iron-sulfur clusters occurs in the mitochondria and involves the action of the Cys desulfurase supercomplex, which is activated by the protein frataxin (FXN). The decrease of FXN... |
41484240 | Longitudinal analysis of neutralizing antibodies against SARS-CoV-1 and different SARS-CoV-2 strains in breakthrough and unvaccinated COVID-19 patients in Thailand (2021-2022). | The emergence of SARS-CoV-2 variants that evade immune responses poses challenges to effective prevention. We prospectively enrolled 111 COVID-19 patients in Thailand (2021-2022), who received homologous or heterologous vaccines or were unvaccinated. Plasma neutralizing antibody (nAb) levels against SARS-CoV-1 and 13 S... |
41484153 | Genetic diversity of Collaborative Cross mice implicates FFAR3 as a target for ILC2 anti-inflammatory reprogramming. | Pulmonary group 2 innate lymphoid cells (ILC2s) are key drivers of Type 2 inflammation in diseases like asthma, yet the molecular mechanisms regulating their function are incompletely understood. Using the genetically diverse Collaborative Cross (CC) mouse panel, we mapped a quantitative trait locus (QTL) that governs ... |
41484054 | Peptide-functionalized membrane camouflage for endogenous H<sub>2</sub>S-induced photothermal immunotherapy of orthotopic colorectal cancer. | The significant challenges pose by the high recurrence and metastasis rates of colorectal cancer (CRC) persist in its diagnosis and treatment. Activating innate immunity in CRC treatment has the potential to reduce drug resistance and side effects. Here, we develop a biomimetic platform by utilizing antimicrobial pepti... |
41483474 | Optimizing Intracellular Transport of Antimicrobial Metallohelices Delivers Selective Nanomolar Potency in <i>E. coli</i>. | To investigate large discrepancies in antimicrobial potency between cationic amphipathic metallohelix architectures, 22 new optically pure candidates were synthesized via self-assembly. A total of 34 compounds were tested against <i>S. aureus</i>, <i>E. coli</i>, and, for the most active, against a panel of ESKAPE path... |
41483472 | Decoding Desulfurization Pathways in Metal-Organic Frameworks (MOFs) via Experimental and Computational Approaches: A Step toward Sustainable Fuel Purification. | Two new metal-organic frameworks, {[Cu<sub>2</sub>(BPDC)<sub>2</sub>(Bipy)<sub>2</sub>]·2DMF}<i><sub>n</sub></i> (<b>MM-1</b>) and {[Zn<sub>3</sub>(BPDC)<sub>3</sub>(Bipy)]4H<sub>2</sub>O·2DMF}<i><sub>n</sub></i> (<b>MM-2</b>), were synthesized using biphenyl-4,4'-dicarboxylic acid (BPDC) and 4,4'-bipyridine (Bipy) mix... |
41483470 | Protein Biomaterials with Muscle-like Water-Driven Actuation. | Unlike muscles, man-made shape-morphing biomaterials take much longer times to perform their actuation. Here we report a novel class of protein-based actuators that mimic muscle contraction through ethanol-induced fibril formation in bovine serum albumin (BSA) hydrogels, enabling reversible shape changes and fast, wate... |
41483360 | ZBP1 Mediates Renal Tubular Injury in Diabetic Nephropathy Through RIPK3-mediated Necroptosis. | Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. Given the limited therapeutic options, identifying novel differentially expressed genes and therapeutic targets is crucial for DN. We performed transcriptome sequencing of kidney tissue from DN patients and applied bioinformatics analyses to ide... |
41483336 | Visualizing DNA repair factor recruitment at sites of transcription in single cells. | Transcription-associated torsional stress presents a continuous threat to genome integrity that needs to be tightly controlled. Here we present a method for the visualization of genome maintenance events at sites of active transcription, which builds on a previously developed reporter system that allows for the detecti... |
41483200 | Highly sensitive detection of luteolin with AuNPs-MXene functionalized electrochemical sensing platform. | The sensitive detection of luteolin is crucial for monitoring its levels in botanical sources, assessing its clinical pharmacokinetics, and guaranteeing the efficacy of luteolin-containing products. In this study, a high-performance electrochemical sensing platform for luteolin detection was developed based on a gold n... |
41482967 | Noncovalent Interaction-Driven Assembly Endows Casein Amyloid Fibrils with Inhibitory Activities against Starch-Hydrolyzing Enzymes. | Casein, owing to its amphiphilic and self-assembling properties, can transform into amyloid fibrils (CNAF), which exhibit distinct bioactivity. In this study, it was innovatively found that the fibrillation of casein significantly enhances its inhibitory activity against starch-hydrolyzing enzymes. Specifically, the pr... |
41482890 | Bacterial Toxin Exploits Host Membrane Phospholipid as a Receptor for Binding, Entry, and Cytopathogenicity. | Mycoplasma pneumoniae is a leading cause of bacterial community-acquired pneumonia, responsible for severe respiratory and extrapulmonary diseases in children and adults. The Community Acquired Respiratory Distress Syndrome (CARDS) toxin is a key virulence factor that exerts ADP-ribosylating and vacuolating activities ... |
41482856 | Nose to Brain Delivery of Curcumin Loaded Therapeutic Nanostructures for Neurodegenerative Diseases. | Neurodegenerative diseases are progressive disorders that damage and eventually kill neurons in the central nervous system (CNS). In recent years, various research has been done on reliable and effective treatment methods for the most common neurodegenerative diseases such as Parkinson's, Alzheimer, and Migraine diseas... |
41482515 | Surface/Interface Engineering for High-Resolution Micro-/Nano-Photodetectors. | Photodetectors can convert light energy into electrical signals, so are widely used in photovoltaics, photon counting, monitoring, and imaging. Photodetectors are easy to prepare high-resolution photochips because of their small size unit integration. However, these photodetector units often exhibit poor photoelectric ... |
41971830 | Accelerating amine-based CO<sub>2</sub> capture with machine learning: From molecular screening to process optimization. | Amine-based CO<sub>2</sub> capture represents the most mature approach for large-scale carbon reduction, with systems implemented across multiple industrial demonstration projects globally. However, vast chemical spaces encompassing millions of potential formulations and complex multiscale coupling effects pose unprece... |
41837217 | Temperature Effects on the Structural Stability of EF<sub>4</sub>K Peptide Membranes: Insights into Mono- and Multilayer Architectures. | Peptide nanostructures are versatile supramolecular systems with potential applications in biomaterials and nanotechnology, where stability emerges from the cooperative action of noncovalent interactions. In this study, we investigated the bola-amphiphilic peptide EF<sub>4</sub>K assembled into nanomembranes, focusing ... |
41727378 | Transmission Electron Microscopy for Structural Insights into Bacterial Cellulose Nanowhiskers in Ternary Deep Eutectic Solvent. | In this study, we used Transmission Electron Microscopy (TEM) to establish that bacterial cellulose formed nanowhisker (BCWN) rod-like structures with distinct short and long morphologies when fabricated in a ternary deep eutectic solvent (TDES) of choline chloride, imidazole, and tannic acid. STEM-EDS confirmed nanowh... |
41659215 | Functionalizing metal nanoclusters in water: Synthesis, interfacing, and emerging applications. | Atomically precise metal nanoclusters (MNCs) are metallic kernels wrapped by ligand shells whose chemistry dictates solubility, stability, and interfacial reactivity. Focusing on water-soluble MNCs, this review treats the interface as the bridge from synthesis to function. We map out both direct aqueous syntheses and g... |
41635354 | Idiopathic Localized Acquired Cutis Laxa in an Adult Male: A Case Report. | Cutis laxa (CL) is a rare connective-tissue disorder characterized by loose, inelastic skin due to defects in elastic fiber production or structure. Acquired cutis laxa (ACL) typically develops in adulthood and may follow inflammatory or immune-mediated events, though idiopathic cases remain uncommon. We report a 29-ye... |
41614182 | Twisted Allenyl-Pyridocyclophanes by Templated Cyclooligomerization: Chiral Cavities for Precision Molecular Recognition. | We report the palladium-catalyzed one-pot synthesis of enantiopure 20-, 30-, and 40-membered cyclophanes shaped by axially twisted allene units. Under Cs<sup>+</sup>-template, the two smaller macrocycles (<b>2</b> and <b>3</b>) are favored over the largest (<b>4</b>). X-ray studies reveal that <i>rac</i>-<b>2</b> assem... |
41594614 | Nano-Engineered Delivery of the Pro-Apoptotic KLA Peptide: Strategies, Synergies, and Future Directions. | Antimicrobial peptides have been increasingly recognized as potential anticancer agents, with the KLA peptide (KLAKLAK<sub>2</sub>) being one of the most well-known and successful examples. The research interest in the KLA peptide is attributed to its ability to induce apoptosis in cancer cells by disrupting the mitoch... |
41590719 | Tailoring the Properties of Marine-Based Alginate Hydrogels: A Comparison of Enzymatic (HRP) and Visible-Light (SPS/Ruth)-Induced Gelation. | Alginate is a natural polysaccharide extracted from brown algae and is commonly used as a biomaterial scaffold in tissue engineering. In this study, we performed phenol functionalization of sodium alginate based on chemical modification methods using 1-ethyl-(3-dimethylaminopropyl)carbodiimide/N-hydroxybutanediimide/2-... |
41590577 | A Bipolar Membrane Containing Core-Shell Structured Fe<sub>3</sub>O<sub>4</sub>-Chitosan Nanoparticles for Direct Seawater Electrolysis. | Seawater has attracted increasing attention as a promising resource for hydrogen production via electrolysis. However, multivalent ions present in seawater can reduce the efficiency of direct seawater electrolysis (DSWE) by forming inorganic precipitates at the cathode. Bipolar membranes (BPMs) can mitigate precipitate... |
41590075 | Ultra-Short Peptide Hydrogels as 3D Bioprinting Materials. | Ultra-short peptides (USPs; ≤7-8 amino acids) emerge as minimal self-assembling building blocks for hydrogel-based biomaterials. Their intrinsic biocompatibility, straightforward synthesis, and ease of tunability make them particularly attractive candidates for potential use in bioprinting. This review provides an over... |
41590078 | Carrier-Free Supramolecular Hydrogel Self-Assembled from Triterpenoid Saponins from Traditional Chinese Medicine: Preparation, Characterization, and Evaluation of Anti-Inflammatory Activity. | Inflammation is the body's natural immune response to invasion by foreign pathogens and is closely linked to many diseases. Chronic inflammation, if not properly controlled, can pose serious health risks and even threaten life. Currently, the main anti-inflammatory drugs are classified into steroidal and non-steroidal ... |
41585656 | A New Robust 3D Cd(II) Coordination Polymer Engineered with Hexamethylenetetramine: Structure, Computational Insights, and Optical Properties. | This work reports a novel cadmium-(II)-hexamethylenetetramine (HMTA) hybrid complex, [Cd<sub>2</sub>Cl<sub>4</sub>(H<sub>2</sub>O)<sub>3</sub>(C<sub>6</sub>H<sub>12</sub>N<sub>4</sub>)]·2H<sub>2</sub>O, whose synthesis, crystal structure, and structure-property relationships are thoroughly investigated. Single-crystal ... |
41585560 | Multi-component chitosan-pectin films reinforced with <i>Padina pavonica</i> nanocellulose and <i>Thymus algeriensis</i> essential oil for red meat shelf-life enhancement. | Perishable foods, including fresh meat, are particularly susceptible to microbial spoilage, lipid oxidation, and progressive quality degradation during storage. Conventional plastic packaging provides physical protection but lacks active functions to delay these processes, while also raising environmental concerns. The... |
41561572 | Cocrystal Engineering of Organic Semiconductors for Photovoltaic Applications: Modeling Excited-State Properties of a Charge Transfer Cocrystal of a Dicarbazole Donor and a Fluoranil Acceptor. | With the recent advancements in lightweight, flexible, and environmentally benign organic supramolecular aggregates for various optoelectronic applications, cocrystals of aromatic π-donors and π-acceptors have emerged as promising <i>n</i>-type semiconductors and near-infrared absorbers for enhanced photovoltaic proper... |
41561434 | Diastereoselective Synthesis of <i>cis</i>-α,α'-Disubstituted Cyclic Ethers via Borane-Catalyzed Reductive Cyclization of Diketones. | Cyclic ethers, particularly <i>cis</i>-α,α'-disubstituted tetrahydrofurans (THFs) and tetrahydropyrans (THPs), are prevalent motifs in bioactive compounds. However, efficient stereoselective methods for accessing such motifs remain limited. Herein, we report a direct catalytic approach to <i>cis</i>-2,5- and <i>cis</i>... |
41561323 | Elucidating HER2-directed chimeric antigen receptor (CAR) activation mechanism using homology modeling and all-atom molecular dynamics simulation. | HER2-directed chimeric antigen receptor (CAR) T cells have demonstrated robust <i>in vivo</i> cytotoxic activity against HER2-positive tumors. However, the structural basis of CAR activation and signal transduction across the membrane remains poorly defined due to the lack of full-length, high-resolution CAR structures... |
41552723 | Busulfan inhibits <i>Pseudomonas aeruginosa</i> growth and reduces biofilm biomass and pyocyanin production. | <h4>Background</h4><i>Pseudomonas aeruginosa</i> remains a serious threat in clinical settings, especially among patients who are immunocompromised, receiving chemotherapy, or in intensive care units. With the rise of antibiotic resistance, drug repurposing offers a promising alternative strategy. Busulfan, an anticanc... |
41552719 | The blood purification therapy-based strategy effectively rescued the severe falciparum malaria patient experiencing cytokine storm-driven MODS. | <h4>Background</h4>The mortality of severe falciparum malaria is high, in which cytokine storm (CS) plays an important role, and the standard effective therapy strategy remains unclear.<h4>Methods</h4>A 63-year-old severe falciparum malaria patient with CS was treated with therapeutic plasma exchange (TPE) combined wit... |
41552574 | Synthetic Biology Strategies for Activating Cryptic BGCs in <i>Streptomyces</i>: Engineering Native and Synthetic Promoters for Antibiotic Discovery. | The activation of cryptic biosynthetic gene clusters (BGCs) in <i>Streptomyces</i> has emerged as a powerful strategy to uncover novel antibiotics. Recent advances in native and synthetic promoter engineering have enabled precise transcriptional control over silent gene clusters. This review presents a comprehensive ov... |
41552557 | Application of Colloid Material in Prevention and Control of Coal Spontaneous Combustion in Coal Mine. | Filling and sealing ventilation leakage are critical strategies for preventing coal spontaneous combustion. Based on the essential conditions for coal self-heating and ignition, this paper comprehensively reviews the research progress, fire-suppression mechanisms, and application limitations of currently used colloidal... |
41552477 | Improving Clinical Diagnostics and Patient Care through Artificial Intelligence and Biosensor Technologies. | This perspective analyzes the substantial advantages of Artificial Intelligence (AI) and machine learning (ML) in improving the efficacy and precision of biosensors, facilitating accurate detection of diverse physiological signals. Moreover, it emphasizes contemporary developments in biosensor technology and their uses... |
41551985 | Ligand-modified liposomes as drug delivery systems for the active targeting of pancreatic cancer. | Pancreatic cancer is among the most fatal malignancies worldwide. The aggressive nature of this disease, coupled with late-stage diagnosis and limited therapeutic options, highlights the urgent need for innovative treatment approaches. Targeted therapy has emerged as a promising strategy to enhance therapeutic efficacy... |
41551768 | Near-infrared light-driven photocatalytic reactive oxygen species-generating antibacterial and self-shrinking hybrid hydrogels for combating drug-resistant bacterial biofilm infection and accelerating wound healing. | The development of wound dressings with tunable antibacterial activity and controllable self-shrinkage remains an intractable medical task for treating drug-resistant bacterial biofilm-infected wounds. Herein, we prepared a near-infrared-light (NIR)-controlled hydrogel (Co-BOS@C/F Gel) using an oxygen vacancy (OV)-rich... |
41551770 | Synergistic mitochondrial homeostasis regulation and cholinergic circuits reconstruction via a one-step synthesized multifunctional hydrogel facilitates spinal cord injury repair. | Neural Stem Cells (NSCs) possess significant potential to form new neural networks. However, following spinal cord injury (SCI), mitochondrial dysfunction leads to the excessive accumulation of reactive oxygen species (ROS), which severely impairs the neuronal differentiation of endogenous NSCs and thus hinders neural ... |
41551762 | LRP-1/CD44-targeted regorafenib nano-delivery system leveraging anti-angiogenesis and synergistic cytotoxicity against peritoneal metastasis of colorectal cancer. | Peritoneal metastasis of colorectal cancer (PM-CRC) represents a major therapeutic challenge in advanced disease, where aberrant tumor vasculature contributes to poor prognosis. To address the pharmacological limitations of regorafenib (REG), this study developed a dual-receptor-targeted nanoplatform (REG@LFHA NPs) tha... |
41551758 | Supramolecular helicity dependent osteogenesis and angiogenesis crosstalk of periodontal ligament stem cell. | The two pillars supporting effective tissue regeneration are multipotent stem cells and matrix materials that direct differentiation. The chirality of the extracellular matrix is a key structural characteristic that affects stem cell fate. However, little is known about the effects of either molecular chirality or supr... |
41551757 | Antifreezing hydrogels for biomedical applications from design strategies to emerging multifunctionality. | Antifreezing hydrogels are gaining increasing attention as promising materials for biomedical applications in subzero environments, including cryopreservation, cold-adaptive bioelectronics, wearable sensing, and tissue engineering. Despite recent progress, this is still a relatively underexplored research area, with ma... |
41551738 | A growth-coupled progesterone-responsive biosensor for high-throughput microfluidic screening in <i>Saccharomyces cerevisiae</i>. | Poor aqueous solubility of steroid precursors, such as pregnenolone and progesterone, limits microbial biotransformation and high-throughput strain screening, representing a bottleneck for strain improvement and potential industrial applications. To address this, we developed a growth-coupled progesterone-responsive bi... |
41551653 | Mesotrione alters the structure of network interactions between soil microbes and affects C and N cycling functions. | Mesotrione is a widely used herbicide in corn production. However, its persistence in soil following application can cause significant damage to subsequent crops such as tobacco. Despite its widespread use, it remains unclear how mesotrione applications affect soil carbon and nitrogen cycling, as well as whether they a... |
41551427 | Polyphenols in food and food wastes: Extraction, isolation, and health applications. | Despite decades of polyphenol research, an integrated perspective on their biosynthesis, advanced extraction methods from food wastes, and potential as versatile inhibitors of pathogenic proteins and enzymes, particularly incorporating modified drug-likeness criteria, remains elusive. This integrative review compares a... |
41550919 | VHH-based CAR-T cells targeting Claudin 18.2 show high efficacy in pancreatic cancer models. | <h4>Background</h4>Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers, with a 5-year survival rate below 10%, largely due to late-stage diagnosis and the limited effectiveness of conventional therapies such as surgery, chemotherapy, and radiation. Claudin 18.2 (CLDN18.2)has emerged as a promis... |
41550792 | Entropy comparison of benzothiadiazole-based covalent-organic frameworks. | Covalent Organic Frameworks (COFs) are popular photocatalysts that utilize solar energy to generate hydrogen peroxide and evolve hydrogen because of their intrinsic porosity, robust framework, and excellent structural regularity. Benzothiadiazole-based donor-acceptor type COFs, PC-NB and PC-NPB, having distinct π -brid... |
41550336 | Clinical-grade plant-made nanomaterials: from process design to the construction of a manufacturing facility. | Plant-made nanomaterials are proteinaceous elements that are emerging as multi-purpose and versatile tools in the therapeutic landscape. In the context of autoimmune diseases, Tomato Bushy Stunt Virus (TBSV) has been previously explored as a platform for inducing immune tolerance by displaying disease-specific immunodo... |
41519042 | Engineering the microenvironment of Cu-MOF nanozyme via modulating ligand hydrophobicity for array-based profiling of phenolic acids in natural products. | Natural products and their synthetic analogs have historically been fundamental to drug discovery, making their identification crucial for pharmaceutical research. This work presents a nanozyme-based sensor array for precise discrimination and quantitative determination of seven phenolic acids in plant-derived natural ... |
41517202 | <i>Auricularia auricula</i> Polysaccharide Modulates Rheological, Thermal, and Structural Properties of Wheat Gluten via Selective Regulation of Glutenin and Gliadin. | This study investigated the effects of <i>Auricularia auricula</i> Polysaccharide (AAP) concentrations on the rheological and thermal properties of gluten and its subunit components. We used multiple techniques, including dynamic rheology, differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy... |
41517198 | A Review of High-Throughput Optical Sensors for Food Detection Based on Machine Learning. | As the global food industry expands and consumers demand higher food safety and quality standards, high-throughput detection technology utilizing digital intelligent optical sensors has emerged as a research hotspot in food testing due to its advantages of speed, precision, and non-destructive operation. Integrating cu... |
41516357 | Mitochondrial Health Through Nicotinamide Riboside and Berberine: Shared Pathways and Therapeutic Potential. | Mitochondrial dysfunction represents a central hallmark of aging and a broad spectrum of chronic diseases, ranging from metabolic to neurodegenerative and ocular disorders. Nicotinamide riboside (NR), a vitamin B<sub>3</sub> derivative and efficient precursor of NAD<sup>+</sup> (nicotinamide adenine dinucleotide), and ... |
41516348 | Special Issue "Molecular Insights into Hair Regeneration". | Hair follicle development and regeneration depend on an intricate interplay of molecular signals, genetic factors, and environmental influences [...]. |
41515822 | Enhanced Toluene Combustion over Cryptomelane Catalysts: Influence of Cu Doping on Physicochemical Properties and Catalytic Performance. | The catalytic combustion of toluene over cryptomelane and Cu-doped cryptomelane catalysts was investigated to evaluate the effect of copper incorporation on catalytic performance. It was found that a small addition of Cu into the cryptomelane framework resulted in a notable decrease in the temperature of 90% toluene co... |
41515470 | Marine Macroalgal Polysaccharides in Nanomedicine: Blue Biotechnology Contributions in Advanced Therapeutics. | Marine macroalgae represent a versatile and sustainable platform within blue biotechnology, offering structurally diverse polysaccharides that are making significant contributions to next-generation therapeutical applications. Algae are rich sources of high-value biomolecules, including polysaccharides, vitamins, miner... |
41515081 | Lotus Seeds: Current Molecular Biology Insights and Future Perspectives as a Prominent Biological Resource. | Lotus (<i>Nelumbo nucifera</i> Gaertn.) is an economically and medicinally significant aquatic plant, with its seeds (lotus seeds) having attracted considerable attention due to their unique developmental traits and abundance of bioactive and nutritional components. Over recent decades, advancements in lotus genome ann... |
41515078 | Edible Coatings for Fresh Fruits: Functional Roles, Optimization Strategies, and Analytical Perspectives. | Fresh fruits are inherently prone to postharvest deterioration due to loss of moisture, respiration, mechanical damage, and microbial decay, making quality preservation a persistent challenge across fresh fruit supply chains. While conventional plastic packaging offers barrier protection and cost-efficiency, its enviro... |
41514817 | Phosphorus Metabolism and Function in Ruminants: Current Knowledge. | Phosphorus (P) is a key macromineral essential for numerous physiological processes, including energy metabolism, skeletal mineralization, and cellular signaling. In dairy cattle, its homeostasis is tightly regulated by parathyroid hormone, calcitriol, and fibroblast growth factor 23 (FGF23). Phosphorus deficiency is c... |
41506137 | Polydopamine-functionalized PCN-224-supported Pt-Pd bimetallic nanozyme with intrinsic oxidase activity for hydrogen peroxide-free ultrasensitive colorimetric sensing of ascorbic acid. | Ascorbic acid (AA), an essential water-soluble antioxidant in humans, plays a critical role in disease prevention and health maintenance, necessitating accurate detection methods. However, conventional H<sub>2</sub>O<sub>2</sub>-dependent colorimetric methods face inherent limitations, creating a demand for alternative... |
41500159 | Ginger oil strengthens the efficacy of Sini Decoction in relieving acute cold stress-caused intestinal damage in broilers. | Cold stress has emerged as a major threat to the global poultry industry, and it has been reported to exert adverse effects on the intestinal system of broilers. In this study, Sini Decoction (SND) and Sini Decoction enriched ginger oil (SNDO) were prepared and characterized. Then, its effect on gut health in acute col... |
41500106 | A multifunctional hierarchical metal-organic aerogel monolithic catalyst with secondary hollow-structure for the oxidation-condensation tandem reaction. | The elaborately crafted microstructure and the accommodated active species of catalyst hold great significance for improving catalytic performance. The synthesis of hierarchical multifunctional catalysts through the integration of two or more distinct active sites in porous supports (e.g., metal-organic frameworks (MOF... |
41499849 | Dual-state emissive carborane-based aza-oxa-triazole macrocycles as probes for nitroaromatic compounds. | A series of o-carborane-based aza-oxa-triazole macrocycles (No, D<sub>2</sub>, D<sub>4</sub>) were synthesized via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC). Simply by substituting the azide diethanolamine precursor, two dansyl-modified macrocycles (D<sub>2</sub> and D<sub>4</sub>) with dual-state emission (DS... |
41488153 | Fabrication of Fructooligosaccharide-<i>Larimichthys crocea</i> Peptide Copolymer by Wet-Heating for Enhanced Calcium Delivery and Bone-Lipid Metabolism Regulation. | Calcium delivery systems based on food-derived peptides and polysaccharides offer a promising strategy for improving calcium bioavailability while preserving peptide bioactivity. In this study, a fructooligosaccharide-<i>Larimichthys crocea</i> peptide (FOS-LCP) copolymer was fabricated by wet-heating and evaluated as ... |
41488016 | Design of B-Cell Multi-Epitope Subunit Vaccines Against <i>Glaesserella parasuis</i> by Reverse Vaccinology: An In Silico and In Vivo Study. | Glässer's disease caused by <i>Glaesserella parasuis</i> (GPS) is a severe disease that results in substantial economic losses to the swine industry worldwide. Here we describe a multiepitope vaccine cocktail (MEVC) that was designed using reverse vaccinology and immunoinformatics. The MEVC was comprised of three multi... |
41485488 | A self-amplifying cuproptosis nanomedicine to overcome immunosuppression by blocking tumor-derived exosomes for enhancing lung cancer immunotherapy. | Lung cancer immunotherapy remains limited by the immunosuppressive tumor microenvironment (TME) and insufficient immunogenicity. Accumulating evidence indicates that tumor-derived exosomes (TDEs) play a pivotal role in shaping the immunosuppressive TME. Consequently, therapeutic strategies targeting TDE biogenesis and ... |
41484189 | Physics informed machine learning for predictive toxicology and optimization of curcumin nanocarriers. | Curcumin's clinical utility is limited by poor bioavailability and dose-dependent toxicity. Although nano-encapsulation can address these shortcomings, rationally optimizing nanocarrier biosafety remains challenging due to the highly multidimensional design space. Here, we develop an interpretable Physics-Informed Mach... |
41484176 | A combined DFT-MD study on the adsorption behavior of allicin on silver-organic framework surfaces. | This research explores the adsorption characteristics of allicin (ALC) molecules on the metal-organic framework (MOF) designated as AgH<sub>8</sub>C<sub>6</sub>N<sub>3</sub>O<sub>2</sub>, or Ag-MOF, focusing on three different surface orientations: 100, 010, and 001. The binding strength of ALC molecules on different f... |
41484161 | A multi-objective optimization-driven screening approach for maximizing hydrogen storage capacities in MOFs. | The inherent tradeoff between gravimetric and volumetric hydrogen storage capacities in metal-organic frameworks (MOFs) limits their commercial viability. While benchmarked MOFs like MOF-5, IRMOF-20, and PCN-610 perform well at 77 K, maintaining their performance at elevated temperatures (298 K) remains challenging. To... |
41484146 | Salmonella typhimurium co-expressing cytolysin A and hyaluronidase suppresses tumor growth and metastasis. | Recently, various attenuated bacteria have been studied as cancer therapies due to their unique characteristics, which include tumor-targeting bioactivity and immunogenicity. Previously, we reported a Salmonella typhimurium strain, CNC018, which is attenuated by 10⁵-10⁶-fold compared with the wild-type strain but retai... |
41484135 | Neutralizing human monoclonal antibodies to poliovirus map to the receptor binding site. | Poliovirus remains a serious threat to human health. Complete eradication of wild-type poliovirus has not yet succeeded, making the development of successful antivirals critical. Microneutralization assays against all three poliovirus serotypes identified a panel of human monoclonal IgGs, which are either serotype-spec... |
41484063 | MCJ modulates mitochondrial ETC flux to promote lipid metabolism-driven enhancement of cell proliferation and migration. | Mitochondrial metabolism plays a crucial role in cancer progression and is associated with effective channeling of electrons through Complex I. The ability to adapt this electron flow as per cellular demands is critical for energy homeostasis. Our observations suggest that proliferating cells regulate the electron entr... |
41483686 | Preclinical characterisation of the protective capacity of an anti-nucleoprotein hRSV monoclonal antibody. | <h4>Background</h4>The human respiratory syncytial virus (hRSV) is a pathogen of global concern, causing significant morbidity and mortality, mainly in preterm infants. To date, all licenced monoclonal antibodies (mAbs) developed against hRSV have targeted its surface fusion or pre-fusion protein (F-hRSV).<h4>Methods</... |
41483199 | Rhodamine B-encapsulated MOF@boric acid-modified COF for adsorption and ratiometric fluorescence detection of baicalin. | Efficient adsorption and sensitive detection of baicalin (BAI) are essential for maximizing its medical value. In this work, a rhodamine B (Rb)-encapsulated metal-organic framework (MOF)@boric acid-modified covalent organic framework (COF) composite material (Rb-MOF@COF-BA) was designed for high-capacity adsorption and... |
41482703 | MOF-Derived High-Entropy Biphasic Sulfides for Zn-I<sub>2</sub>-S Synergistic Batteries with Machine-Learning-Assisted Prediction and In Situ Synchrotron Spectroscopy. | The practical application of aqueous zinc batteries remains constrained by the intrinsic limitations of monocomponent systems, such as the shuttle effect in Zn-I<sub>2</sub> batteries and the sluggish kinetics in Zn─S batteries. To overcome these limitations, we developed a Zn-S-I<sub>2</sub> synergistic battery that s... |
41482580 | The membrane transition strongly enhances biopolymer condensation through prewetting. | Biopolymers that separate into condensed and dilute phases in solution also prewet membranes when one or more components couple to membrane lipids. Here we demonstrate that this prewetting transition becomes exquisitely sensitive to lipid composition when membranes have compositions near the boundary of liquid-ordered/... |
41482545 | Cross-presentation of dead cell-associated antigens shapes the neoantigenic landscape of tumor immunity. | Type 1 conventional dendritic cells (cDC1s) acquire and cross-present tumor antigens to prime CD8⁺ T cells. Whether this selects for specific neoantigens is unclear. DNGR-1 (CLEC9A), a cDC1 receptor for F-actin exposed on dead cells, promotes cross-presentation of cell-associated antigens. Here we show that DNGR-1-defi... |
41482506 | Bone-Targeting Gallium-Gallic Acid Metal-Organic Framework (GGMA) for Dual Anti-Inflammation and Osteo-Regeneration Therapy of Osteoporosis. | With the acceleration of global population aging, the incidence of osteoporosis continues to rise, posing a significant public health challenge. Current treatments exhibit limited efficacy and struggle to simultaneously regulate the abnormal inflammatory microenvironment within osteoporotic lesions. Consequently, there... |
41482484 | Complex 2D Square Nanopatterns via Intrinsic Anisotropic Confinement. | Square patterns are integral to industry-standard rectilinear coordinate systems, yet fabricating complex two-dimensional (2D) square patterns remains a formidable challenge. Herein, we report the emergence of complex 2D nanopatterned morphologies with <i>p</i>4<i>mm</i> and <i>p</i>4<i>gm</i> plane group symmetries an... |
41481938 | Quantitative Degradation Rate Assessment of bioPROTACs Based on Peptide Degrons, E3 Domains, Adapters and Conjugated Small Molecules. | Protein-based bispecific degraders, known as bioPROTACs, have emerged as powerful tools for targeted protein degradation through the ubiquitin-proteasome system (UPS). However, the relative efficacy of various recruitment domains within these degraders remains poorly understood. To address this knowledge gap, we conduc... |
41481905 | Open-Air Plasma Treatment to Enhance Nanoparticle Adhesion on Nylon- and Cotton-Based Fabrics for Chemical Protection. | Nylon- and cotton-based fabrics, particularly a 50:50 nylon-cotton blend ("NYCO"), are commonly used for military and workforce garments. Developing high-throughput methods to attach reactive or sorptive metal oxide or metal-organic framework (MOF) nanoparticles (NPs) is important for chemical protection. Open-air plas... |
41481844 | Efficient Sampling of Short Protein Trajectories with Conditional Diffusion Models. | Understanding how protein structures dictate their diverse biological functions remains one of the central and enduring challenges in structural biology. The development of AlphaFold and ESMAtlas marks a significant advance in protein science, enabling the reliable prediction of protein structure directly from amino ac... |
41481823 | Morphological Engineering of Zn(II)-Tripyridine Supramolecular Catalysts for CO<sub>2</sub> Photoconversion to CO. | In this study, we designed and synthesized a novel organic ligand (<b>L3Tpy</b>) using lysine as a bridging unit and terpyridine as the core coordinating group. A <b>Zn-L3Tpy</b> coordination polymer gel (CPG) was subsequently prepared via a facile one-step ultrasonic treatment of a precursor solution containing <b>L3T... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.