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41481824 | Spatially Resolved Single-Water Entropy around Amino Acids and Its Link to Hydropathy. | The hydrophobic effect is a crucial guiding force in biological processes such as protein folding, molecular recognition, and structural stability. The enthalpy-entropy interplay at the hydration shell offers key insights into these phenomena. Although molecular dynamics simulations estimate enthalpy, determining entro... |
41481811 | Exploring Lignin Conformation in Organic and Deep Eutectic Solvents Using Small-Angle Neutron Scattering. | Lignin, a structurally intricate and heterogeneous phenolic biopolymer, holds considerable promise as a sustainable alternative to petrochemical-derived materials across diverse applications in the energy and materials sectors. However, precise lignin molecular weight and structure determination remains challenging due... |
41481814 | Beyond the Single Molecule: Multiplexed Methods in Force Spectroscopy. | Single-molecule techniques have transformed biological research by enabling direct observation and manipulation of individual molecules. These methods overcome ensemble averaging inherent in bulk measurements and facilitate studies under physiological stresses and out-of-equilibrium conditions. They have provided valua... |
41481806 | Membrane-Mimetic Micelles Drive Structural Switching in Uperin 3.5. | Uperin 3.5, an antimicrobial and amyloidogenic peptide from frog skin secretions, may represent an important evolutionary link between host-defense peptides and functional amyloids. Its ability to switch between α-helical and β-sheet conformations in membrane-associated environments makes it a compelling model for unde... |
41481797 | Crystal Surface Reactivity of Esterase@Zeolitic Imidazolate Framework Biocomposites. | Esterase@zeolitic imidazolate framework (Esterase@ZIF) biocomposites have been synthesized by biomineralization of pig liver esterase to explore the synergistic interplay between esterase and the ZIF framework on crystal surface reactivity and biocompatibility. The targeted Esterase@ZIF crystal phases cover a wide rang... |
41481768 | Mapping the Hierarchical Environmental Transformations of Nanoscale UiO-66 Metal-organic Framework. | Metal-organic frameworks (MOFs) hold immense potential for applications from separations to catalysis, yet their long-term behavior across real-world environments remains unclear. Here we introduce a hierarchical exposure framework that tracks the structural and chemical transformations in the archetypal zirconium MOF ... |
41481745 | Mechanical control of the insect extracellular matrix nanostructure. | Nanoscale modifications of apical extracellular matrix (ECM) have created various functional surfaces with distinct physical properties, exemplified by structural coloration and superhydrophobicity in animals and plants. To reveal the mechanisms, we investigated cuticle morphogenesis in <i>Drosophila</i> olfactory orga... |
41481743 | A softness zwitterionic micelles efficiently deliver inhaled nintedanib by enhancing airway mucus penetration. | Inhalation therapy shows great potential for treating idiopathic pulmonary fibrosis (IPF), but airway mucus imposes strong adhesive and steric barriers to drug delivery. Compared with other types of micelles, our results demonstrated that amphiphilic micelles formed by DSPE-PCB [carboxybetaine polymer conjugated to 1,2... |
41481744 | Febrile temperature activates the innate immune response by promoting aberrant influenza A virus RNA synthesis. | Fever during influenza A virus (IAV) infection is triggered by the innate immune response. Various factors contribute to this response, including IAV mini viral RNAs (mvRNA), which trigger RIG-I signaling when their replication and transcription are dysregulated by template loops (t-loops). It is presently not well und... |
41481733 | Architectural principles of transporter-chaperone coupling within the native MHC I peptide-loading complex. | Adaptive immunity depends on major histocompatibility complex class I (MHC I) presentation of peptides, a process orchestrated by the peptide-loading complex (PLC) in the endoplasmic reticulum (ER). The PLC ensures precise peptide selection and loading and is a major target of viral immune evasion, notably by human cyt... |
41481710 | Dual-receptor targeting of type I dendritic cells with DNA-scaffolded nanoparticles enhances STING-licensed antitumor immunity. | Activating the stimulator of interferon genes (STING) pathway in conventional type I dendritic cells (cDC1s) is crucial for inhibiting solid tumor metastasis. A major hurdle is the cell type-specific delivery of immune agonists. To overcome this, we created a DNA-scaffolded poly(lactic-<i>co</i>-glycolic acid) nanopart... |
41481708 | Bacteriocin-transport-inspired oral peptide-probiotic delivery ameliorates IBD complications via autophagy and gut homeostasis. | Intestinal fibrosis (IF), a severe complication of inflammatory bowel disease (IBD), remains a critical unmet clinical need. Although the LL37 peptide and probiotics demonstrate therapeutic potential against IF, their clinical translation is hampered by enzymatic hydrolysis and rapid clearance. Here, inspired by the st... |
41481598 | Discovery of Supra-Bivalent GSK3β Inhibitory Peptides Containing an ATP-Mimetic Amino Acid. | De novo discovery of highly selective inhibitors of protein kinases (PKs) remains a significant challenge in drug discovery. Although ATP-site-directed bivalent inhibitors targeting a distinct binding site are an emerging alternative, their rational design is impeded by limited knowledge about allosteric binding sites ... |
41481585 | Diversified Morphology of Electrospun Fibers through Self-Assembly of the Strings in the Jet Developed by Flow-Induced Phase Separation. | Solution electrospinning produces not only round fibers but also many unexpected features, e.g., ribbons, nets, and fibers with beads, barbs, or branches along the fiber length. These diversified features are observed in the electrospun fibers of poly(vinyl alcohol), Nylon-6, poly(<i>N</i>-isopropylacrylamide), ultrahi... |
41481484 | Insights into the complexity of SARS-CoV-2 M<sup>pro</sup> inhibition: Ebselen and its derivatives impair dimerisation of the enzyme. | The SARS-CoV-2 Main Protease (M<sup>pro</sup>), a key enzyme for viral replication, represents a highly attractive target for the development of broad-spectrum anti-coronavirus therapeutics. The organoselenium drug Ebselen has shown potent <i>in vitro</i> inhibition of M<sup>pro</sup> as well as antiviral activity, gra... |
41481483 | Research progress on triterpenoids in the genus <i>Rubus</i>: a comprehensive review. | The <i>Rubus</i> genus, a critical resource within the Rosaceae family, exhibits extensive distribution across both temperate and tropical regions. The abundant triterpenoids in these plants have garnered considerable attention due to their diverse structures and important biological activities. To date, a variety of t... |
41481442 | Dysregulation of a nucleotidyltransferase induces division and surface glycan defects in <i>Escherichia coli</i> by altering related metabolite levels. | The cell surface of gram-negative <i>Escherichia coli</i> is rich in glycoconjugates, including O-antigen (O-Ag) and enterobacterial common antigen polysaccharides, which mediate interactions with the environment. Enzymes called nucleotidyltransferases produce nucleoside diphosphate sugars (NDP-sugars), the precursors ... |
41481406 | Light-Controlled Functions with Metal-Organic Capsules: From Guest Release to Catalysis, Separation, and Molecular Transport. | ConspectusLight offers a clean and precise means to control chemical processes. These advantages have opened the door to the development of dynamic host-guest systems, whose functions can be turned on or off with specific wavelengths. Over recent years, we have developed a suite of light-responsive metal-organic capsul... |
41481363 | From Molecular Interactions to Nanocarrier Design: Coarse-Grained Modeling of PEG Self-Assembly and Hindsiilactone Encapsulation. | Polyethylene glycol (PEG)-based nanocarriers represent a promising strategy for delivering hydrophobic natural products like Hindsiilactone A (HINA), yet the molecular mechanisms governing polymer-drug interactions and optimal formulation parameters remain poorly understood. This study establishes quantitative design p... |
41481351 | A Versatile Ni(II) MOF Catalyst for Synthesis of Oxazolidinones via Three-Component Fixation of CO<sub>2</sub> and Synthesis of Imines via Aerobic Oxidation of Benzylamine. | A new Ni(II)-based metal-organic framework (MOF), designated as <b>IITG-8</b> (IITG stands for Indian Institute of Technology, Guwahati), has been successfully synthesized and thoroughly characterized. The thermally activated form of <b>IITG-8</b> (<b>IITG-8a</b>) was employed as an efficient heterogeneous catalyst for... |
41481267 | Polymeric Lysosome-Targeting Chimeras (PolyTACs): Extracellular Targeted Protein Degradation without Co-Opting Lysosome-Targeting Receptors. | Extracellular targeted protein degradation (eTPD) is an emerging modality to regulate protein levels without genomic interruption. Current strategies co-opt lysosome-targeting receptors (LTRs) that are ubiquitously present in most cells, offering a high success rate of eTPD across cell types and tissues. To circumvent ... |
41481210 | Dopamine Self-Polymerization-Assisted Oriented Antibody Immobilization on a Transistor for Alzheimer's Disease Diagnosis. | Antibody transistor biosensors show promise for early Alzheimer's disease (AD) diagnosis due to their single molecule detection capability. However, the random attachment of a payload to antigen-binding fragments (Fab) during biosensor preparation can disrupt target recognition, leading to poor consistency and repeatab... |
41481089 | Helical Polymers: From Precise Synthesis to Structures and Functions. | Helices are ubiquitous in Nature and play indispensable roles in biological systems. A helix with an excess of one-handed helicity can be optically active because left- and right-handed helices are nonsuperimposable enantiomers. Stimulated by natural helices and their broad applications as chiral materials, artificial ... |
41481087 | Squaramide-Based MOF Enables Hydrogen-Bond-Directed Ultraselective Guanine Detection and Drug Monitoring. | Guanine (G), an essential biomolecule indispensable for organismal development, manifests concentration fluctuations closely associated with various pathological conditions, thereby establishing its quantitative detection as a clinically imperative objective. Inspired by the specificity of Watson-Crick hydrogen-bonding... |
41481031 | Albumin Nanoparticles Co-Loaded with Dual Drugs for Enhanced Ferroptosis-Based Cancer Therapy through Modulating Cholesterol Metabolism. | Ferroptosis is a form of regulated cell death driven by lipid peroxidation, in which the diffusion of lipid peroxidation substrates on the plasma membrane is hindered by lipid rafts, thereby inhibiting the ferroptosis process. Lipid rafts are microdomains composed of cholesterol, sphingolipids, and specific proteins. N... |
41481005 | Caging the Chlorine Radical: Chemoselective Photocatalytic C(sp<sup>3</sup>)-H Functionalization Enabled by Terminal Cu-Cl Sites in a Metal-Organic Framework. | Hydrogen atom transfer (HAT) mediated by halogen radicals represents a powerful approach for the functionalization of inert C(sp<sup>3</sup>)-H bonds. Chlorine radical (Cl<sup>•</sup>), for example, is capable of generating carbon-centered radicals by abstracting strong C-H bonds (H-Cl bond dissociation energy = 103 kc... |
41480931 | ActivityFinder: Toward the Fully Automatic Integration of Structural and Binding Affinity Data. | The reliable integration of structural and bioactivity data remains a significant bottleneck in computational chemistry and cheminformatics. While curated databases such as PDBbind and ChEMBL provide valuable resources, integrating structural data in the form of, for example, PDB files and bioactivity assays in the for... |
41480787 | Thermoresponsive Magnetic Hydrogel for Local Thermal Ablation Treatment of Rectal Cancer. | Thermal ablation treats cancer by raising local tumor temperature above ∼50 °C to induce coagulative necrosis. However, current approaches are invasive, as they typically require needle-like applicators to deliver thermal energy directly into the tumor. In this study, a magnetic hydrogel was developed as a noninvasive ... |
41480717 | From Cellular Organization to Synthetic Platforms: Liquid-Liquid Phase Separation as a Framework for Functional Biomolecular Condensates. | Liquid-liquid phase separation (LLPS) is a fundamental biophysical process driving the formation of dynamic biomolecular condensates, which spatially organize cellular biochemistry without membrane delimitation. These condensates arise from multivalent, weak interactions among intrinsically disordered proteins, modular... |
41480689 | Role of cuproptosis in digestive system tumors (Review). | In cells, copper levels are tightly regulated because copper deficiency leads to Menkes disease, anemia and neurodegeneration, whereas copper overload is associated with Wilson disease, liver injury, neurodegeneration and several cancers. Cuproptosis, a form of regulated cell death, depends on the intracellular accumul... |
41479031 | Achieving Wide-Temperature-Range Physical and Chemical Hydrogen Sorption in a Structural Optimized Mg/N-Doped Porous Carbon Nanocomposite. | Nanoconfinement is a promising approach to simultaneously enhance the thermodynamics, kinetics, and cycling stability of hydrogen storage materials. The introduction of supporting scaffolds usually causes a reduction in the total hydrogen storage capacity due to "dead weight." Here, we synthesize an optimized N-doped p... |
41437510 | Protocatechuic acid attenuated inflammation caused by <i>Prevotella copri</i> and its metabolites. | Gut microbiota has been considered as a key bridge between phytochemicals and host immunity. <i>Prevotella copri</i> (<i>P. copri)</i> showed a close correlation with inflammation, and protocatechuic acid (PCA) has potential protective effects in our previous studies. To understand the underlying mechanism, a total of ... |
41370860 | The phase transformation from MOF to hierarchical catalysts and their non-enzymatic glucose sensing performance. | Herein, Co-MOF arrays were used as a precursor to fabricate hierarchical catalysts. Heterostructure Co-MOF/Co(OH)<sub>2</sub>and Co(OH)<sub>2</sub>micro-nano sheet arrays were fabricated by etching treatment in ultrapure water for different time. When treated for 60 min, infrared spectrum and x-ray diffraction (XRD) pa... |
42006482 | Chemical characterization of Jing Guan Fang and its application in alleviating coronavirus envelope protein-induced proinflammatory responses <i>in vitro</i> and <i>in vivo</i>. | <h4>Background and aim</h4>Jing Guan Fang (JGF) is an herbal formulation developed for the prevention of COVID-19 via SARS-CoV-2 infection. In this study, we aimed to clarify the anti-inflammatory effects of JGF on macrophages stimulated by the SARS-CoV-2 envelope protein (2-E) both <i>in vitro</i> and <i>in vivo.</i><... |
42004516 | Rosemary (<i>Rosmarinus officinalis</i> L.) and nervous system disorders: New findings on its neuroprotective properties. | Rosemary (<i>Rosmarinus officinalis</i> L.) has gained recognition for its neuroprotective potential, offering therapeutic benefits for various nervous system disorders. Its main components, including rosmarinic acid, carnosic acid, and ursolic acid, exhibit anti-oxidant, anti-inflammatory, neurotransmitter-modulating,... |
42004509 | Improved bioavailability of raloxifene hydrochloride through nasal administration of poly (methyl vinyl ether-co-maleic acid) nanoparticles in ovariectomized rats. | <h4>Objectives</h4>To improve the low bioavailability of Raloxifene hydrochloride (RH), which is just 2% through oral administration, an in situ mucoadhesive thermoreversible gel loaded with RH nanoparticles was formulated using Pluronic F127.<h4>Materials and methods</h4>Mucoadhesion of the gels was modulated using Ca... |
42004510 | Syringic acid attenuates LPS-induced acute lung injury via modulation of the HMGB1/TLR4/NF-κB and Keap1/Nrf2/HO-1 pathways: Mechanistic insights from <i>in vivo</i> and <i>in silico</i> studies. | <h4>Objectives</h4>Sepsis-induced acute lung injury (ALI), driven by uncontrolled inflammation and oxidative stress, remains a major cause of mortality in critically ill patients. This study aimed to investigate the protective and mechanistic effects of syringic acid (SA), a natural phenolic compound, against lipopolys... |
41987665 | TCMToxDB: a comprehensive database for the toxicological analysis of traditional Chinese medicines. | The safety and modernization of traditional Chinese medicine (TCM) are significant concerns for human beings. Recently, the adverse effects caused by the use of certain TCMs have been frequently reported. Although TCMs may cause toxic reactions, they also play critical roles in treating multiple complex diseases. There... |
41970696 | Epidemiological trends, antimicrobial resistance, and genetic mutations of <i>Mycoplasma pneumoniae</i> in Wuhan, China: a post-COVID-19 perspective. | <h4>Objectives</h4>This study aimed to investigate the epidemiological trends, antimicrobial resistance patterns, and genetic mutations associated with <i>Mycoplasma pneumoniae</i> infections in Caidian District, Wuhan, Hubei Province.<h4>Methods</h4>Totally 7,234 nasopharyngeal swabs were collected from patients with ... |
41970697 | Immunoinformatics and molecular modeling approaches to design a multi-epitope vaccine against Tibrovirus Congo. | <h4>Objectives</h4>The objective of this study was to design and evaluate a computationally optimized multi-epitope vaccine targeting the G protein and nucleoprotein of Tibrovirus Congo using immunoinformatics and molecular simulation approaches.<h4>Methods</h4>B-cell and T-cell epitopes were predicted, screened for an... |
41969205 | The Role of Blood-Brain Barrier in Brain Cancer: From Pathophysiology to Therapeutic Approaches. | Brain tumors remain among the most lethal cancers, in part due to the limited ability of therapeutic agents to reach malignant cells protected by the blood-brain barrier (BBB). This specialized vascular interface preserves neural homeostasis through several mechanisms and different elements. In brain malignancies, the ... |
41936447 | Effect of Molecular Conformation and Deformation Energy on Stability of β-Cyclodextrin Inclusion Complexes with Epi-Type Catechins in Water. | This study investigated the inclusion complexation mechanisms between epi-type catechins and β-cyclodextrin (βCD) in aqueous solution through isothermal titration calorimetry (ITC), rotating-frame nuclear Overhauser effect spectroscopy (ROESY), and molecular modeling simulations (MMS). The ITC measurements revealed tha... |
41930473 | Molecular modulation of cell migration via chitosan-based hydrogels: Toward smart biomaterial for wound regeneration. | Chitosan-derived hydrogels offer a highly tunable scaffold for orchestrating the multifaceted process of wound repair, yet their full potential hinges on an integrated understanding of biochemical and biophysical cues. Here, we provide a concise yet comprehensive analysis of design parameters that govern cell-matrix in... |
41930423 | [Research of interaction of fluorescent anti-CD133 DNA aptamers with glioblastoma cell cultures using flow cytometry]. | Glioblastoma or grade IV glioma is characterized by extremely poor prognosis. Resistance to radio- / chemotherapy and recurrences are associated with tumor stem cells. Transmembrane protein CD133 is considered a potential marker of tumor stem cells. To overcome the limitations of detecting cellular CD133 by antibodies,... |
41927110 | Integrating Mendelian Randomization and Epithelial Barrier Assays Reveals Protective Effects of Acetate and Histidine Against Cholesterol Depletion-Induced Esophageal Dysfunction in GERD. | <h4>Objective</h4>This study aims to evaluate the causal relationship between serum biomarkers and gastroesophageal reflux disease (GERD) using Mendelian Randomization (MR) and validate key findings through in vitro functional assays.<h4>Methods</h4>Genome-Wide Association Study (GWAS) data for GERD were sourced from t... |
41925124 | Advances of Green-Synthesized Nanoparticles for Biomedical Applications. | In biomedical nanotechnology, plant-mediated production of metallic nanoparticles has become a viable and physiologically adaptable method that offers decreased toxicity, enhanced biocompatibility, and functional surface modification by phytochemical capping. In addition to altering physicochemical characteristics, inc... |
41924156 | 3D bioprinting of skin equivalents: Towards functional wound healing models. | Developing physiologically relevant human skin models remains a critical challenge in regenerative medicine and disease modelling, particularly for chronic wounds that involve persistent inflammation and vascular dysfunction. Recent advances in 3D bioprinting provide improved spatial organisation and reproducibility co... |
41924127 | Complex viral interactions revealed for the harmful bloom-forming dinoflagellate <i>Karenia brevis</i>. | <i>Karenia brevis</i> regularly forms harmful blooms along the West Florida Shelf that negatively affect marine and terrestrial organisms through toxin production. These blooms impose economic and environmental hardship, driving the need for research to understand the factors influencing their dynamics and to mitigate ... |
41917660 | In Vivo Detection of IAA Using IAA Nanosensor. | Indole-3-acetic acid (IAA) is an important auxin phytohormone that regulates development, directional growth, and stress responses in plants. Here, we provide a detailed method and protocol for use of a corona phase molecular recognition-based IAA nanosensor that allows for direct and real-time measurement of IAA in pl... |
41909748 | Multivalent sulphur-modified biosilica nanostructures for bacterial enteritis therapy. | Bacterial enteritis is a specific gastrointestinal tract disorder caused by pathogenic bacterial infection, which not only disrupts the commensal microbiota but also contributes to cascaded complications. Here, we prepared polyethyleneimine (PEI)-based mesoporous silica nanostructures, co-modified with -SH and -S-S- gr... |
41909141 | Tutorial on Energy Transfer Mechanisms and Computational Methods in X‑ray Photodynamic Therapy with Metal Nanoclusters. | Cancer remains the deadliest disease for mankind, and hence, the need for effective, reliable, and functioning cancer treatment is crucial. A promising minimally invasive oncological treatment called photodynamic therapy (PDT) involves irradiation of a photosensitizing drug injected into the vasculature which in turn t... |
41884956 | Quantitative analysis of oligonucleotide delivery into isolated mitochondria: a proof-of-concept method. | Mitochondria, with their own DNA, Represent a potential target for nucleic acid-based precision therapies. However, effective delivery of therapeutic oligonucleotides remains challenging due to the dual mitochondrial membranes and the localization of mitochondrial DNA within nucleoid complexes in the matrix. To underst... |
41883488 | Advances in esophageal organoids: from construction to applications. | Esophageal organoids are self-assembled 3D microtissues derived from pluripotent or adult stem cells. They accurately recapitulate the cellular composition, tissue arrangement, and functional properties of the native esophagus. Emerging as powerful tools in disease research, they overcome key limitations of 2D cultures... |
41871342 | Stepwise preparation, structure, and in vitro biotestings of the monoribbed-heterodifunctionalized bis-α-benzildioximate iron(II) clathrochelates with two terminal biorelevant groups as potential cytotoxic agents. | The title novel cage complexes were prepared using two-stage nucleophilic substitution of their dichloromacrobicyclic precursor and characterized using elemental analysis, MALDI-TOF mass, UV-vis, 1H and 13C{1H} NMR spectra, and single-crystal XRD experiments. Their chemical compositions suggest an existence of 3D-shape... |
41854333 | Role of myeloid cells expressing CD169/Siglec-1 in host-pathogen interactions. | CD169/Siglec-1 is a type-I transmembrane lectin receptor expressed on subcapsular sinus macrophages and activated monocytes, which plays a key role in innate immune surveillance and orchestration of adaptive immunity. As a sialic acid-binding immunoglobulin-like lectin (Siglec), CD169 recognizes sialylated gangliosides... |
41852711 | Developing an innovative chimeric multi-epitope subunit vaccine against <i>Staphylococcus intermedius</i> using an immunoinformatics strategy via Multi-omics approaches. | <h4>Background</h4><i>Streptococcus intermedius</i> is a major human pathogen associated with invasive diseases such as meningitis and endocarditis. These infections may lead to inflammation, fever, and cardiac damage. At present, no effective vaccine exists for prevention.<h4>Objectives</h4>This study aimed to design ... |
41852706 | Computational design of a multiepitope vaccine targeting VP1 and VP2 capsid proteins of simian virus 40 (SV40) for enhanced immune activation. | <h4>Objectives</h4>This study aimed to design and evaluate a computationally constructed multiepitope vaccine targeting Simian Virus 40 (SV40) by predicting and selecting immunogenic B-cell and T-cell epitopes derived from the VP1 and VP2 capsid proteins using bioinformatics approaches.<h4>Methods</h4>B and T-cell epit... |
41852482 | Construction of pomelo peel essential oil pickering emulsion and its impact on the freeze-thaw stability of surimi gel. | Surimi gel products, often subjected to multiple freeze-thaw (F-T) cycles during storage and transport, suffer from texture deterioration and drip loss. High-fat additives, used to improve mouthfeel and gel properties, raise health concerns. This study aimed to improve F-T stability and reduce fat content by constructi... |
41848047 | Persistent antimicrobial resistance during soil remediation driven by residual heavy metal co-selection. | Remediation of heavy metal-contaminated soil is a global priority, particularly as reclaimed land increasingly intersects with urban development and human exposure. However, the ecological consequences of soil remediation, especially its impact on antimicrobial resistance (AMR) as a global health threat, have remained ... |
41843876 | Application of Proteins Binding Components of Bacterial Cell Wall for Extraction, Concentration, and Analysis of Biological Samples. | Proteins that bind components of bacterial cell wall play a key role in innate immunity and interactions between bacteria and host organisms. They participate in the control of peptidoglycan synthesis and degradation, determine the pathogenic specificity of bacteria, affect their ability to adhere and invade, and serve... |
41834520 | Varying Patterns of Breeding Use on Duck Farms in China and Implications for Microbial Resistance Strategies. | The study evaluated the effects of different breeding modes on production performance, microbial population, breeding costs, and economic efficiency of broiler ducks. The results showed that the bacterial detection rates of the cage-rearing system (CRS) ducks were all lower than the flat-rearing system (FRS) ducks. Two... |
41818311 | The ancient E-ring in bacterial flagellar motors. | The bacterial flagellum is an elaborate nanomachine that powers motility in a variety of environments. While recent cryo-electron tomography studies have revealed great complexity as well as diversity in flagellar motor structures, less is known about the components that constitute the auxiliary structures observed in ... |
41814756 | [Effect of decoction method on phase state and biological activity of Cinnamomi Cortex-Coptidis Rhizoma supramolecular]. | Based on supramolecular chemistry of TCM, this study investigated the interaction between Cinnamomi Cortex-Coptidis Rhizoma herb pair and compared phase states and bioactivity differences under different decoction methods(co-decoction vs individual decoction followed by mechanical mixing). Phase state variations were o... |
41814730 | [Molecular dynamics simulation and experimental verification reveal processing detoxification mechanism of Pinelliae Rhizoma Praeparatum]. | This study aims to investigate the effects of glycyrrhizic acid and calcium ions from adjuvant solutions on the toxic lectin in Pinelliae Rhizoma Praeparatum and clarify the processing detoxification mechanism. Molecular docking and molecular dynamics simulations were employed to construct a 3D model of lectin and eval... |
41767886 | Quo Vadis translational neuroscience? | Translational neuroscience is a research discipline that aims to transfer findings from basic research in neuroscience into clinical applications. The main goal of this research discipline is to gain molecular and mechanistic insight into brain diseases and to devise novel diagnostic tools and therapeutic applications.... |
41765403 | Development of Frontier Artificial Nucleoside Derivatives through Precise Nucleic Acid Recognition for Drug Discovery. | Artificial nucleic acids-engineered through fine-tuned molecular design based on organic synthetic chemistry and focused on nucleic acid molecular recognition-show significant potential in drug discovery, especially in the development of nucleic acid therapeutics and drugs. This review underscores recent advancements i... |
41765388 | Instillation of Hesperetin Nanosuspensions Prevent Lens Opacification in Selenite-Induced Cataract Rats. | Hesperetin (HST) exhibits antioxidant activity and helps prevent cataract formation when administered orally. However, low bioavailability limits its efficacy. However, formulating HST as an ophthalmic preparation may improve its delivery to ocular tissues, making it a more effective option for cataract prevention. In ... |
41758920 | Butyric acid-based self-assembling nanoparticles: a potential strategy to prevent development of polycystic ovary syndrome. | Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting women of reproductive age and cannot currently be cured or prevented fundamentally. Prenatal androgen exposure is a key factor in PCOS development, and both PCOS patients and animal models exhibit gut microbiota alterations. We previously ... |
41758122 | Harnessing eCISs for precision phytomicrobiome engineering and biocontrol. | Plant microbiome disruption often increases vulnerability to crop diseases, endangering worldwide food production, while chemical pesticides become increasingly less viable and continue to damage ecosystems. To safeguard plant microbiome health, several biological control strategies offer alternatives, yet many operate... |
41757133 | Innovative Peptide Therapeutics for SARS-CoV-2: Design, Docking, and Functional Analysis. | <h4>Background</h4>The continuous emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants necessitates the rapid development of novel therapeutics, particularly those targeting conserved viral proteins. Peptide-based drugs offer high specificity and low toxicity, making them ideal candidates.... |
41755504 | Nitrogen blowing DµSPE of sunitinib, imatinib, and dasatinib using LDH/MIL-101(Cr)-NO<sub>2</sub> composite prior to HPLC-PDA. | <h4>Background</h4>The therapeutic bioanalytical challenge activity of tyrosine kinase inhibitors (TKIs) can be assessed by measuring them in biological samples such as plasma and serum. Determining these compounds requires an efficient sample before the analysis to minimize matrix effects and enhance preconcentration.... |
41747225 | Treatment of infected endografts after thoracic endovascular aortic repair: a systematic review. | ObjectiveThe infection of the endograft after thoracic endovascular aortic repair (TEVAR) is a rare but potentially life-threatening complication. Unfortunately, clinical reports, large case-series or randomized studies are scarce or not available yet, and the optimal management of this complication is under debate. Th... |
41742558 | Preliminary metabolic characterization of hepatic lipidosis in cats using liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry: pathway insights and candidate biomarkers. | <h4>Background</h4>Feline hepatic lipidosis (FHL) lacks well-defined metabolic biomarkers and mechanistic understanding.<h4>Hypothesis/objectives</h4>Clarify the metabolic biomarkers and mechanisms of FHL.<h4>Animals</h4>Two groups of cats were analyzed: 14 cats (7 FHL cases and 7 healthy controls) for liver metabolomi... |
41744225 | Towards accurate artificial intelligence models for strain-level phage-host prediction. | Strain-level prediction of phage-host interactions (PHIs) is essential for developing targeted phage therapies. Traditional empirical and homology-based methods often lack the resolution and scalability needed for precision applications. Recently, a new generation of artificial intelligence-driven models has emerged le... |
41736915 | A global thermodynamic-kinetic model capturing the hallmarks of liquid-liquid phase separation and amyloid aggregation. | Amyloid aggregation is associated with numerous neurodegenerative, systemic, and metabolic diseases. Amyloidogenic proteins often undergo liquid-liquid phase separation (LLPS), but the effects of LLPS on amyloid aggregation remain unclear, as contrasting fibrillization promotion and inhibition and even biphasic effects... |
41733245 | Exploring cooperation among social pathogens: a computational perspective. | Once centered on animal social behavior, investigations into cooperation have expanded across the tree of life to include micro-organisms such as bacteria and viruses. Cooperative interactions are now understood to drive evolutionary dynamics within and between numerous microbial species and communities, including path... |
41729824 | Revealing shared molecular markers and mechanisms in colorectal cancer and COVID-19 through bioinformatics and machine learning. | Colorectal cancer (CRC) and Coronavirus Disease 2019 (COVID-19) are distinct diseases that may share overlapping molecular mechanisms, particularly in immune dysregulation. However, the specific regulatory pathways driving this shared pathophysiology have remained elusive, as prior studies have been limited by single-l... |
41729820 | Structure-informed machine learning for drug discovery: a task-centric perspective. | Advances in protein structure prediction have transformed the landscape of structure-based drug discovery, enabling deep learning models to incorporate spatial constraints into the design of target-specific ligands. This review provides a comprehensive synthesis of structure-aware molecular modeling from a task-centric... |
41720714 | Intravenous miR-30c therapy confers dual neurovascular protection and improves long-term recovery after ischemic stroke. | Ischemia-reperfusion (I/R) injury is a major barrier to effective reperfusion therapy in acute ischemic stroke. Secondary microvascular thrombosis and neuronal endoplasmic reticulum (ER) stress are major contributors to poor outcomes, yet therapeutic strategies that simultaneously target both processes remain limited. ... |
41716301 | Advances in peptide nucleic acid for targeting RNA and genomic DNA. | Peptide nucleic acid (PNA) is a synthetic mimic of DNA where the deoxyribose-phosphodiester backbone is replaced with N-(2-aminoethyl) glycine units. The lack of deoxyribose-phosphodiester bonds enhances enzymatic stability and improves binding affinity of PNA with complementary DNA and RNA strands. To enhance target b... |
41715802 | Elastic properties of polycatenane chains and ribbons. | Single-chain elasticity is of fundamental importance in polymer physics, as it underlies many of the unique properties of polymer systems. Recently, there has been interest in characterizing the elastic properties of catenanes, molecular architectures composed of linked molecular rings. To date most studies have focuse... |
41711750 | Ubiquitin-Specific Protease 10: A New Target in Tumor Immune Escape. | Tumor immune escape is a major challenge in cancer treatment, and targeted immune escape therapy has become a key strategy for cancer treatment. As an important deubiquitinating enzyme, ubiquitin-specific protease 10 (USP10) participates in the process of tumor development by adjusting the balance between ubiquitinatio... |
41710066 | The impact of chemical modifications of antisense oligonucleotides on CTX-M-15 β-lactamase target affinity and expression of ceftriaxone-resistant <i>Escherichia coli</i>. | Antimicrobial resistance is a current public health challenge. In line with the new One Health policy and the World Health Organization priority pathogen list, this study explores antisense oligonucleotides targeting ß-lactamase CTX-M-15, responsible for one of the most prevalent mechanisms of resistance to third-gener... |
41707204 | From hemocuprein to CSRP: the many faces of Cu/Zn superoxide dismutase. | From bacteria to humans, the highly conserved Cu- and Zn-containing superoxide dismutase (Cu/Zn SOD) plays a pivotal role in free radical biology. By using Cu to disproportionate superoxide at rates that approach diffusion limits, Cu/Zn SODs are premier antioxidants. Interestingly, during eukaryotic evolution, several ... |
41705721 | Mechanistic studies of hydrogels in oral cancer treatment: Synergistic effects of drug delivery and immune modulation. | Oral cancer ranks among the most prevalent malignant tumors of the head and neck, comprising 1%-2% of all global malignancies. Despite advancements in surgery, radiotherapy, chemotherapy, and immunotherapy, challenges remain in oral cancer treatment, including high recurrence rates, severe side effects, and limited eff... |
41700488 | Nanoscale Helical Heterojunctions From a π-Conjugated Emitter With Two Heterochiral Centers. | Chirality transfer from molecules to supramolecular architectures underpins diverse biological and material functions, yet constructing helical heterojunctions remains a formidable challenge. Here, we report the discovery of nanoscale helical junctions directed by a molecular chiral junction derived from a meso-form li... |
41693061 | The harmonies played by miR-302/367 cluster in pluripotency, reprogramming, and rejuvenation. | The conserved, pluripotency-associated miR-302/367 cluster coordinates cell fate and aging via epigenetic, cell cycle, and signaling regulation. Highly expressed in pluripotent stem cells and silenced during differentiation, it promotes efficient somatic cell reprogramming by suppressing senescence mediators (eg, p16IN... |
41686698 | Exosomal nanocarriers of immune fate: molecular insights into cancer immunity, pathogen defense, and emerging immunotherapies. | Exosomes, the nanoscale extracellular vesicles released by most cell types, are increasingly recognized as potent regulators of immune communication. This review provides a mechanistic and integrative perspective on the immunological functions of exosomes, highlighting their roles in both immune stimulation and suppres... |
41678239 | Investigation of nutritional and functional roles of β-mannanase on intestinal health and growth performance of nursery pigs fed low-cost formulated diets with high phytase inclusion. | The objective of this study was to investigate the impacts of low-cost formulated diets (LCD) with high phytase inclusion on intestinal health and growth performance of nursery pigs, and roles of β-mannanase in mitigating these impacts. Thirty-six pigs (6.2 ± 0.2 kg initial body weight; BW) were individually housed and... |
41678215 | Dietary supplementation with 25-hydroxycholecalciferol is more effective than cholecalciferol in improving reproductive performance in aged duck breeders. | This study aimed to evaluate the effects of supplementing two vitamin D sources on reproductive performance, egg quality, and plasma biochemical indices of aged duck breeders, and to estimate vitamin D requirements and relative bioavailability from these two sources. A total of 180 laying Pekin ducks (64 wk of age) wer... |
41661138 | Spatial structure: shaping the ecology and evolution of microbial communities. | Most microbes grow in spatially structured communities, and this profoundly shapes their ecology and evolution. At the microscale, short interaction ranges and steep nutrient gradients underlie cross-feeding, quorum sensing, and niche construction, generating spatial patterns that influence microbial behavior, communit... |
41652163 | Bridging Scales: Coarse-Grained Protein Models in Computational Biology. | Coarse-grained (CG) modeling has emerged as an essential tool in computational biology, offering a simplified yet effective representation of proteins and their interactions. By reducing atomic detail, CG models enhance computational efficiency while preserving critical physical and chemical properties, enabling the st... |
41647070 | Enhancing clomipramine antidepressive effect using nanocomplexes via different routes of administration: A comparative study. | <h4>Objectives</h4>Enhancing clomipramine anti-depressive effect using a nanoformulation and investigating its effect via different routes of administration (oral and intranasal) in a depression rat model. Polyelectrolytes nanocomplexes (NC) were prepared by an all-aqueous technique and were composed of different ratio... |
41641319 | Distal peptide elongation by a protease-like ligase and two distinct carrier proteins. | Closthioamide (CTA) is a potent antibiotic with a unique polythioamide scaffold produced by <i>Ruminiclostridium cellulolyticum</i>. Unlike classical non-ribosomal peptide synthetases (NRPSs), which use modular adenylation and condensation domains, CTA biosynthesis proceeds through non-canonical standalone enzymes. Cen... |
41641144 | Ashwagandha (<i>Withania somnifera</i>) in insulin resistance and metabolic syndrome: A literature review on mechanisms. | Metabolic syndrome is characterized by obesity, insulin resistance, dyslipidemia, and hypertension. <i>Withania somnifer</i>a, commonly known as ashwagandha or Indian winter cherry, belongs to the <i>Solanaceae</i> family. <i>W. somnifera</i>, particularly its powdered root, is a fundamental component of traditional In... |
41640853 | Advancing peptide-based vaccines against viral pathogens: a narrative review. | Peptide-based vaccines, utilizing defined B- and T-cell epitopes, have emerged over the past two decades as promising alternatives to conventional vaccine platforms. Their key advantages, including excellent safety profiles, precise immunological targeting, and ease of manufacture, position them as a versatile tool in ... |
41635500 | Triphenylene as a versatile scaffold for advanced functional materials. | Triphenylenes are a class of polycyclic aromatic hydrocarbon that have been attracting increasing attention owing to their widespread applications in areas such as liquid crystals, organic electronics, photovoltaics, light emitting diodes, and catalysts. The utility of triphenylenes stems from their flatness, rigidity,... |
41635498 | Development of hybrid nanoparticles based on Zr(iv) and perylene-3,4,9,10-tetracarboxylic acid with visible-light photoredox activity. | Herein, we investigate perylene-3,4,9,10-tetracarboxylic dianhydride (PTCDA) as a linker in Zr-clusters. The photostable, 3D metal-organic nanomaterial obtained by a solvothermal synthesis procedure in the presence of formic acid as modulator, named ZIPER, shows strong absorption in the visible (400-560 nm) and an inte... |
41635492 | <sup>17</sup>O NMR spectroscopy in polyoxometalate chemistry: advances, challenges, and applications in structure and catalysis. | <sup>17</sup>O Nuclear Magnetic Resonance (NMR) spectroscopy has become an increasingly valuable technique for investigating the structure, dynamics, and reactivity of polyoxometalates (POMs), a diverse class of metal-oxygen clusters with broad applications in catalysis, energy storage, and materials science. The oxyge... |
41635491 | Investigating the adsorption performance of CO<sub>2</sub>, SO<sub>2</sub>, NH<sub>3</sub> and CH<sub>4</sub> molecules on Sb<sub>3</sub>(TM)O<sub>6</sub> (TM = Sc, Ti, V, Cr, Mn, Fe, Ni, and Co) clusters for gas-sensing applications. | Inorganic molecular clusters (IMCs) belong to a trending class of materials with unique structures and properties. Due to having a gap among the cages, they attract the attention of many researchers. This study is carried out in order to investigate the mechanism of adsorption of CO<sub>2</sub>, SO<sub>2</sub>, NH<sub>... |
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